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<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1C3</accession>
    <name>A0A1V0N1C3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoribonuclease Nob1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nob1</name>
        <name evidence="9" type="ORF">FAD_0015</name>
        <name evidence="10" type="ORF">HLB00_05695</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a type II toxin-antitoxin (TA) system. Processes pre-16S-rRNA at its 3' end (the D-site) to yield the mature 3' end.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000190">
        <property type="protein sequence ID" value="NOL60326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887026.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1C3"/>
    <dbReference type="STRING" id="74969.FAD_0015"/>
    <dbReference type="GeneID" id="16025161"/>
    <dbReference type="KEGG" id="fai:FAD_0015"/>
    <dbReference type="OrthoDB" id="27944at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PIN" evidence="8">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD83950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL60326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="157" mass="17213" checksum="3FCF8A85EB5D0438" modified="2017-06-07" version="1">MEGKKKYIIDTSAMLSGNLNISEDGYVYPESVINEIKKGSLEKILEVANITTRSPGKEYIAKAREAALSTGDYNALSATDIDVLALAIELNGIIITDDYAIQNVAKYCGIAYSGGGISGIKKGIIWKYRCTGCHKIYDEYIKTCPICGHDVKRYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1K4</accession>
    <name>A0A1V0N1K4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0036</name>
        <name evidence="3" type="ORF">HLB00_02725</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000086">
        <property type="protein sequence ID" value="NOL59748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141255.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1K4"/>
    <dbReference type="STRING" id="74969.FAD_0036"/>
    <dbReference type="GeneID" id="84218527"/>
    <dbReference type="KEGG" id="fai:FAD_0036"/>
    <dbReference type="OrthoDB" id="380935at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="80" mass="8945" checksum="5902A35322BFCB70" modified="2017-06-07" version="1">MLLSLLTIYGSVVLTMMMIFYLLESRSPLYSLFFGITCFGSAIYGILAGVYPFGAIESVWGIFSINRYVKRVGKAKNSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1K6</accession>
    <name>A0A1V0N1K6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141289.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1K6"/>
    <dbReference type="STRING" id="74969.FAD_0070"/>
    <dbReference type="GeneID" id="31675582"/>
    <dbReference type="KEGG" id="fai:FAD_0070"/>
    <dbReference type="OrthoDB" id="6534at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004426">
        <property type="entry name" value="PRK05769.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF58">
        <property type="entry name" value="LEUCINE_METHIONINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="450" mass="49879" checksum="A2E2EDC226EC74A3" modified="2017-06-07" version="1">MEKDVLLNGVRITTELPGPNAKKIMAEDEKYLTTSTKSLPVVAYRGQGCYIEDVDDNVFLDFSSGISTTNIGYGNEYVISKVQEQLHKLWHFAGTDFYYEEQVEAAKALIGVSPGSHDKKVFYANSGAESNEASLKLARSYTKRPQFIGFIGGFHGRTMGALSFTASQPVHHEGFFPEMGGVTHIPFPDPYRNPFNIDGYEEPEDLTNAAIDYLEDYVFGKFLPSNSVAAILVEPIQGEGGYIVPPMDFHKKLMELAHENEILYIMDEVQTGFGRTGRFFASEHFGVDPDIMSVAKSIASGIPMGASVVKSKYDFEKSGLHSNTFGGNLLASVSSRATIEEIKNKNMVENARKVGDYLNKRLHELQEKYDSIGDVRGLGLMQAIDFVKNRKTKAHFRGLRDKTIENAYKNGLILLGAGESAIRFIPPLIVSEKQIDEAIDILDNSIKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1L3</accession>
    <name>A0A1V0N1L3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Triosephosphate isomerase</fullName>
            <ecNumber evidence="2">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141343.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1L3"/>
    <dbReference type="STRING" id="74969.FAD_0107"/>
    <dbReference type="GeneID" id="31675619"/>
    <dbReference type="KEGG" id="fai:FAD_0107"/>
    <dbReference type="OrthoDB" id="9465at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003302">
        <property type="entry name" value="PRK04302.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF42">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="216" mass="23532" checksum="5C1A9C943F6A2118" modified="2017-06-07" version="1">MEPEIFINFKHYNNAVGTNSEKLLADFKSIKNQDSLYYCVAETDLYLQKSFPELHIYGQHVDSNGYGAFTGSVSMESLLDLGVKGSLLNHSEKRVDSSIIESIVKKSKELGFKIILCVENLDEAEKYSKLEPAYIAYEPPELIGGDISVSTARPEIIGQAAEICKGRTKLLVGAGVKTKEDVDTSMALGAAGVLIASGIIKNAKPINRLVSLMGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1L5</accession>
    <name>A0A1V0N1L5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0095</name>
        <name evidence="3" type="ORF">HLB00_01740</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000044">
        <property type="protein sequence ID" value="NOL59557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141326.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1L5"/>
    <dbReference type="STRING" id="74969.FAD_0095"/>
    <dbReference type="GeneID" id="31675607"/>
    <dbReference type="KEGG" id="fai:FAD_0095"/>
    <dbReference type="OrthoDB" id="55684at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415:SF3">
        <property type="entry name" value="GNAT-FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415">
        <property type="entry name" value="SPERMIDINE N(1)-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="176" mass="20295" checksum="A3BFA839401E9C9D" modified="2017-06-07" version="1">MILKRDGAVENYAIRRGVPEDAKGIIECMQSVMDEKIYLVSEYYLLTERGERERLKNKDDLTLVCELNGKIAGVTTIQRGMYRKNRHVASLGIAIRKEYRHMGMGTGMIRDAISWSKQQGIEKINLEVFSSNVHAIQAYRNLGFQYEGVRKRQFLIGDRYVDDVLMTYFTSGWNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1P0</accession>
    <name>A0A1V0N1P0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141302.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1P0"/>
    <dbReference type="STRING" id="74969.FAD_0082"/>
    <dbReference type="GeneID" id="31675594"/>
    <dbReference type="KEGG" id="fai:FAD_0082"/>
    <dbReference type="OrthoDB" id="9136at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002805">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003372">
        <property type="entry name" value="PRK04447.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38811">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38811:SF1">
        <property type="entry name" value="UPF0284 PROTEIN SLL1500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="336" mass="36118" checksum="1BCBEE2E42786D5E" modified="2017-06-07" version="1">MEIVEGNNVYNKITDRHDILYILLGGTTQVSTIPGISAAGASPELTKLTPVLDSEIISAGKCISYDVVPMTEEGIPTPSIITRGANEISGINTLIMDAGFIQDPAVPFIKTSLGSAGDGSKEKALQFYERAKAYGSYLGNLLDGKYKFIFLAESVPGGTTTAHTVLSSIGIGEMTSSSMKNSPDAIKESFTARALERTGKLPGYNDSVAEFGDYMMAISLGIGSVINKSTLFYAGGTQMATVFYLDRLINGNNNRYVFTTGYIMKDKEKLMRKLAGQSVLYANMNFSGITGLKYYDEGYVKEGTGFGAAFGISYLLGGNTAPVYSNIKKVYRSFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1P8</accession>
    <name>A0A1V0N1P8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Probable cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobD</name>
        <name evidence="12" type="ORF">FAD_0083</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141304.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1P8"/>
    <dbReference type="STRING" id="74969.FAD_0083"/>
    <dbReference type="GeneID" id="31675595"/>
    <dbReference type="KEGG" id="fai:FAD_0083"/>
    <dbReference type="OrthoDB" id="46105at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00380">
        <property type="entry name" value="cobal_cbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002281">
        <property type="entry name" value="PRK01209.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="COBALAMIN BIOSYNTHESIS PROTEIN CBIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308:SF1">
        <property type="entry name" value="COBALAMIN BIOSYNTHESIS PROTEIN CBIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="318" mass="35364" checksum="509B66D7A8EA31BC" modified="2017-06-07" version="1">MIELLVLALLILFFSILFDVVIGEPQNRIHPVVFIGITISNLKTRFISKNNKIAAGCFFLISIILINTVPLLAVLYLLYIAKNTILLILFAFIYIYFLKSTFSIRGMGTHVNRIINALEKGDLDSAKKYTSLVVRRDTSSMDSGKIASAAVETIAEGFVDGYLTPMFFYAFFGIAGAMVARVINTMDSNIAYRDNIHYEFGRCTAIGDSITNFITSRMAPFIFGISAFLLGIKYAKTRIVNTTDSLNAGYSMGAMAKVLGIRLEKSGEYIINPDAKSPGVNDIKKAMRIYYLSSVLTLLIFVIPVMLVLFVLHIFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1V1</accession>
    <name>A0A1V0N1V1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor 1A</fullName>
            <shortName evidence="5">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">eif1A</name>
        <name evidence="5" type="synonym">eif1a</name>
        <name evidence="10" type="ORF">FAD_0202</name>
        <name evidence="11" type="ORF">HLB00_05830</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5 8">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000196">
        <property type="protein sequence ID" value="NOL60352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887205.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1V1"/>
    <dbReference type="STRING" id="74969.FAD_0202"/>
    <dbReference type="GeneID" id="16025348"/>
    <dbReference type="GeneID" id="84218690"/>
    <dbReference type="KEGG" id="fai:FAD_0202"/>
    <dbReference type="OrthoDB" id="2586at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003084">
        <property type="entry name" value="PRK04012.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003085">
        <property type="entry name" value="PRK04012.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="9">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL60352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="110" mass="12962" checksum="4899F654AAA322B2" modified="2017-06-07" version="1">MDHKIEDNGENITRVITPNKRKGEIYGIVEKLSGASRLTVMCEDGSTRNCRIPGKMKKRMWIREGDLVIVKPWDFQDEKGDIIYRYTRTQALYLSRNRMLPEIIDVFNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1W1</accession>
    <name>A0A1V0N1W1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Probable deoxyhypusine synthase</fullName>
            <shortName evidence="11">DHS</shortName>
            <ecNumber evidence="6 11">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dys</name>
        <name evidence="12" type="ORF">FAD_0214</name>
        <name evidence="13" type="ORF">HLB00_06605</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6 11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000234">
        <property type="protein sequence ID" value="NOL60502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141410.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1W1"/>
    <dbReference type="STRING" id="74969.FAD_0214"/>
    <dbReference type="GeneID" id="84218704"/>
    <dbReference type="KEGG" id="fai:FAD_0214"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000010">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00153">
        <property type="entry name" value="DHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022899">
        <property type="entry name" value="Deoxyhypus_synthase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002294">
        <property type="entry name" value="PRK01221.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL60502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="312" mass="35434" checksum="86B38074DF295E63" modified="2017-06-07" version="1">MEIKREDLLKDPVKDLKINKNTTLMQLMEMFGTSGGFTSKKLYEGYQILKEEFTSDETTFLSFPADIISTGTRGIINQLVKNKLVDVIITTNGTLDHDVARVYTDYYAGTFNFGDEKLKDMNINRLGNVFVPDESYGVVIEEKLMPMIEELYNKKKEWAPVDLIREVGLKLDNENSILYNAAKNNIPVFVPGITDGSFGSQLWSFYEMHHDFKINILEDEHRLSDIVFDAKKTGALMIGGGISKHHTIWWNQFRDGLNEAVYITTAQEYDGSLSGAKLEEAITWKKVRKDAKFVNIYGDATAILPIMVAPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Y3</accession>
    <name>A0A1V0N1Y3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Box C/D RNP protein Nop5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nop5</name>
        <name evidence="2" type="ORF">FAD_0187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Y3"/>
    <dbReference type="STRING" id="74969.FAD_0187"/>
    <dbReference type="KEGG" id="fai:FAD_0187"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="1">
        <location>
            <begin position="153"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="267" mass="30770" checksum="DA2309DD4F27D1DB" modified="2017-06-07" version="1">MEKIMWYGKIIDKKIYLYRNLQKDYMNILESLRQGIIPETEETCSEKIPDLREILLKFEKERINSEFSHDQYIIKVYSVKKELEEIINLYLEKLVSIYTLLDIKYNNDPCLYFSKLKNAGLQDVDNAAAEMGINMCSFRSYLDNYLGNEIEKYMPHTVSLIGKTLALDFLLKSGSLENLVKYPAGTLQILGAEKAFFNHMRKGTPPPKHGIIFNYPGLSALPPNQRGKVARAIANKMAITLKMDFFKTDGDTEGMVNEIKKKMNIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N200</accession>
    <name>A0A1V0N200_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_0258</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887279.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N200"/>
    <dbReference type="STRING" id="74969.FAD_0258"/>
    <dbReference type="GeneID" id="16025425"/>
    <dbReference type="KEGG" id="fai:FAD_0258"/>
    <dbReference type="OrthoDB" id="6747at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002469">
        <property type="entry name" value="Cell division control protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048907">
        <property type="entry name" value="WHD_MCM_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21120">
        <property type="entry name" value="WHD_MCM_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="10">
        <location>
            <begin position="282"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="697" mass="78843" checksum="5A5C35D48103E21A" modified="2017-06-07" version="1">MISQDIEADNIKRQWIDFFDRYDYNDQINKLRSDYPDIKSLYISYNDLSGYSTDFIEGLMKDPYYYLTIGEFYIKETLGITYNKVRRINIRLVNVPEIIGIKYDIRNVRSSNVNSYISINGIIRKNTEVLPRLQNAAFKCPACGELTIVPEDIQKLFEPTACQACGWNKGKLKLIPEESEFVDTQKLEIQENPDTIDSTSQPQRITLIIEDDITGKIYPGDRVTVYGILKADEKHIGNTMLTEYNIYLNVNNFKKETRDFEEIKINDEDEKKIKELAREPNIIDRLAKSIAPSIYGLDVIKKSLVLQLFGGVRKVMKDGTHIRGDIHILMIGDPGTAKSQLLRYMTFISPRSVFAFGKGSSAAGLTAAAVRDDFGEGRWTLEAGALVLADNGFAAIDELDKMDKNDTASMHEAMEQQSVTISKAGIMATLKSRCSILAAANPRFGRYDPMKTIAEQTEFPPPLLSRFDIIFKLIDTPNREIDDKLAEHVLKTNRLGEIYRSLENNNLEIDIPDEENFIAELDKDLIRKYVSYAKNRVFPRLSDEAISILKEEYVKTRASGIDSVPITARQLESTIRLAEAAAKARLSPIITVEDALLAKGVVDYYLKEVSAMNGQVDIDILNTGISTKQRTELEVILSVIKEAKENSGDQKKAPEIETVIEMLKQKGISRERAETDLARLKSDGFIYEPSNKRVDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N216</accession>
    <name>A0A1V0N216_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ORF">FAD_0270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
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        <property type="protein sequence ID" value="ARD84192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N216"/>
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    <dbReference type="GeneID" id="31675779"/>
    <dbReference type="KEGG" id="fai:FAD_0270"/>
    <dbReference type="OrthoDB" id="9540at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
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        <property type="entry name" value="Flavoprotein"/>
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        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="184" mass="20436" checksum="B4E28729207D11A8" modified="2017-06-07" version="1">MKKIVVGITGASGTALGVKFLENIKDMEIHLVMSESAKKVMKLESDYSIDYIKSLADYYYHDSDIAARISSGSFLFDTFVVIPCSSSTLAKISAGISDTLITRVATVAMKERRRFIVVPREMPFSTIMLENMLKLSMNNVIVAPAVPGYYNKPSSVEDLLNFVVARVLDLAGIKNDISPRWRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N242</accession>
    <name>A0A1V0N242_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">HLB00_03130</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
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            <taxon>Thermoplasmata</taxon>
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        </lineage>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
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        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF1">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
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        </location>
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        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="100" mass="10852" checksum="9278E00DBB296426" modified="2017-06-07" version="1">MLQMANNINENCKTTGLVIPSINRNSCEAKGECVSICPYNVFELIPLKDEDKKNMSLVGKLKARAHGGKQAYVIDPALCHSCGDCVKACPEKAITLISIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N243</accession>
    <name>A0A1V0N243_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0240</name>
        <name evidence="2" type="ORF">HLB00_09200</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="31675748"/>
    <dbReference type="KEGG" id="fai:FAD_0240"/>
    <dbReference type="Proteomes" id="UP000192050">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="63" mass="7143" checksum="A601E2DA1C2E3FAE" modified="2017-06-07" version="1">MSGLKEVPSFKTLSRRVRIIDLHSSNKDYYTAIGLKAITYNLTVIPNSELGEKLMEIMKIVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N260</accession>
    <name>A0A1V0N260_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family glucokinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0277</name>
        <name evidence="2" type="ORF">HLB00_06445</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000224">
        <property type="protein sequence ID" value="NOL60471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887299.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N260"/>
    <dbReference type="STRING" id="74969.FAD_0277"/>
    <dbReference type="GeneID" id="16025444"/>
    <dbReference type="KEGG" id="fai:FAD_0277"/>
    <dbReference type="OrthoDB" id="206224at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049874">
        <property type="entry name" value="ROK_cs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964:SF149">
        <property type="entry name" value="BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="ROK (REPRESSOR, ORF, KINASE) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="311" mass="33573" checksum="91DE9E492BAE2A83" modified="2017-06-07" version="1">MYILGYDVGGTKISAVIGDGTGRIMKKITRRTMKDYGKSGITDQLISMGDELIKKAGIEKVSKIGIIFAGPVDSKTGTIISSPNIIGLKNYNITDSIRKHFNVDVYLQNDASASTIAEKLYGAAKNFSNFVYITLSTGIGGGIFIDNKLYKGSHGMAGELGHMVILPNGPICGCGRRGCLEAIASGKGMARRVIENISEVKNSTIFSDMNPADIDAKKIFAARRAGDMFAQLIVEETIYYLAVGIVNIINIFDPQAIIIGGGLSLEGEDLFHPLRLAVREEMKSMKRPVRILKALKNGADLGTIAITQYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N267</accession>
    <name>A0A1V0N267_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141478.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N267"/>
    <dbReference type="GeneID" id="84218806"/>
    <dbReference type="KEGG" id="fai:FAD_0306"/>
    <dbReference type="OrthoDB" id="57510at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="272" mass="32272" checksum="CF3EBF2D3DDA4A3E" modified="2017-06-07" version="1">MKDKMELLWNSIVNYSKKNGFSLYYSTDVDIVISFEWDKHMGGASKFLKNAKDSGIKSLVLSVKRFEDEDMDCSTIDCNKYRNKIAEIDIMYIFNDVGYKYHDEADWFSELNTFNIDDLLEENEEKKVLPLTREVNEKSIDSLVQDMIQYFNNEFPDSSNYDMEENMRTFWLYKGINFDFPVENDLKLKIDKVNHEARRKIENNKKSEERVKLLKLIPAVITETNGNENGIITREQLKNYLSDKGIKVQNSKNIDYMYEQLLKQLRIQNKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N276</accession>
    <name>A0A1V0N276_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps7</name>
        <name evidence="11" type="ORF">FAD_0285</name>
        <name evidence="12" type="ORF">HLB00_04365</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7 9">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000149">
        <property type="protein sequence ID" value="NOL60068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841636.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N276"/>
    <dbReference type="STRING" id="74969.FAD_0285"/>
    <dbReference type="GeneID" id="16025453"/>
    <dbReference type="KEGG" id="fai:FAD_0285"/>
    <dbReference type="OrthoDB" id="45346at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_A">
        <property type="entry name" value="Ribosomal_uS7_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026018">
        <property type="entry name" value="Ribosomal_uS7_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="10">
        <location>
            <begin position="48"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL60068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="187" mass="20936" checksum="8748380EF2601FA1" modified="2017-06-07" version="1">MEQLIMNKYDVSGIQIKDQGLATYINLTSYLNLDTGGRFSNYLSGKRNVNTIERLLNNLMRTEKWTGKKYSAYKVMSQAFDIIATKTKQNPVQILVSAIENSAPREEVTRLKYGGIAVPKSVDVSPSRRLDEALRNIARGATKASFKHKIHIQDCLANEILLAARNDANSFAISKKEEIERVAASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N277</accession>
    <name>A0A1V0N277_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0274</name>
        <name evidence="2" type="ORF">HLB00_06430</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000224">
        <property type="protein sequence ID" value="NOL60468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141443.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N277"/>
    <dbReference type="STRING" id="74969.FAD_0274"/>
    <dbReference type="GeneID" id="84218772"/>
    <dbReference type="KEGG" id="fai:FAD_0274"/>
    <dbReference type="OrthoDB" id="33991at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="293" mass="33522" checksum="8C09D0517C2622C8" modified="2017-06-07" version="1">MQIDKLVYGIYPKTNELRLHIGRWEKGKIPDATLNENIESEKAMFYDLLKEGSIEHTDPLFNWYDILRPVSLIVDGIDLGPLTRFKETNSFYRMPVINNISGISIDPKDFSPLNENPPLPLYVNNGNGFNAFLPSPLSFYKMSRSSIPYGIFQEKIEGVYANILKEFGLKDLVLYDPLPYEKSDILDLSLLGDFKIKLVTTGKLYKNNIKGNLYSIIADYSPENFKISKENSKVPGVKLIDGSNTRLENVNEINRTVESLDADRIIVSHREYFDFLPRLIADRKLDLMSKIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N290</accession>
    <name>A0A1V0N290_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enolase</fullName>
            <ecNumber evidence="6">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 13" type="primary">eno</name>
        <name evidence="12" type="ORF">FAD_0349</name>
        <name evidence="13" type="ORF">HLB00_01470</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 2-phosphoglycerate (2-PG) into phosphoenolpyruvate (PEP). It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds a second Mg(2+) ion via substrate during catalysis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell surface</location>
        </subcellularLocation>
        <text evidence="6">Fractions of enolase are present in both the cytoplasm and on the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000040">
        <property type="protein sequence ID" value="NOL59507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887368.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N290"/>
    <dbReference type="STRING" id="74969.FAD_0349"/>
    <dbReference type="GeneID" id="16025514"/>
    <dbReference type="GeneID" id="84218847"/>
    <dbReference type="KEGG" id="fai:FAD_0349"/>
    <dbReference type="OrthoDB" id="8680at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 6 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="10">
        <location>
            <begin position="132"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>(2R)-2-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>(2R)-2-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="355"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>(2R)-2-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>(2R)-2-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>(2R)-2-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL59507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="402" mass="44083" checksum="BE5A82D48408BC5B" modified="2017-06-07" version="1">MVESIEITDSRITKIFDSRGNPAIEATIILNYATGTSSAPAGASTGKTEVIAYPKNNIDNSVDFYNKHVRNALKGFNALNQSGFDTLLHELDGTDNFSEMGGNLATALSIANAKAVSNYLEIPLYRYVGGLHPQIPRPMGNIIGGGKHSKNGTTIQEFLVSSQGKTFYDSVYYNILVHRRVGEKLSEKLKGQSVGLGDEKAWTADVSDEEAIEIMKEAAGEISSENKVKIYLGVDFAADSFYNNGKYDYKTSKKTQDEQIDYAVSLNKEHGFYFIEDPLYDNDFEGFAEITKKIGEDSLIVGDDLYTTNSARIQKGIDMKSTNAVLIKVNQIGTLSDTVKSVKLATKNSMDTVVSHRSGETTDDFIAHLAVAFNSKFIKTGTIGGERLAKLNEVIRLEEDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N294</accession>
    <name>A0A1V0N294_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispA</name>
        <name evidence="7" type="ORF">FAD_0292</name>
        <name evidence="8" type="ORF">HLB00_04325</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000148">
        <property type="protein sequence ID" value="NOL60060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141458.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N294"/>
    <dbReference type="STRING" id="74969.FAD_0292"/>
    <dbReference type="GeneID" id="84218792"/>
    <dbReference type="KEGG" id="fai:FAD_0292"/>
    <dbReference type="OrthoDB" id="26738at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF85">
        <property type="entry name" value="SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="351" mass="40118" checksum="EB6DE291A73E8313" modified="2017-06-07" version="1">MNNIEDYKKTLDGLKDKINAQLEEYFNFKLNECDDARIKDIIIKLRDFTLNGGKRLRPILMIMGYNMFSGQDERIIKASISIELAQSFLLIHDDIMDQSDMRRGKPSFHKAVEGSLDGNDATRIAENLAISAGDLIDTFSHEALLRSGFELENLLDADFEFSRIIEDTGKGQILDIYSSIENLYSEERLTKLHFLKTARYTVQGPLLMGAYLSGNKKYIQEIKDFGKYAGIAFQLYDDMLGIFGVEEKTGKPVKGDVNEGKKTLLIIKAYENSGKEDREFIESCLKCGDVSDSDFNRLRELIKSTGSYDYTKQKIDEYNNIARSALEKIDGDKEVIKMLDFLLEYLIKREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2D5</accession>
    <name>A0A1V0N2D5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2D5"/>
    <dbReference type="STRING" id="74969.FAD_0329"/>
    <dbReference type="KEGG" id="fai:FAD_0329"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41930:SF1">
        <property type="entry name" value="DEPHOSPHO-COA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41930">
        <property type="entry name" value="UPF0200 PROTEIN MJ1399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20591" checksum="FCBCC7B848F9F030" modified="2017-06-07" version="1">MPGSGKDEFVKVAKSMGFIDAHMGNTVKKNALEKKIPLDDGSIGAYATEERKKYGMDIWAKRTAELITEPDITIVDGLRNEEELDYFKGNFQNIIVIAVFANENDRLERILARDREDDSHNYNGMHQRDNRELSWGIGKVISLADYMIVNDSSLDEYHKNVKILLNHIISRHPEINIKSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2G5</accession>
    <name>A0A1V0N2G5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gyrA</name>
        <name evidence="9" type="ORF">FAD_0374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887394.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2G5"/>
    <dbReference type="STRING" id="74969.FAD_0374"/>
    <dbReference type="GeneID" id="16025540"/>
    <dbReference type="GeneID" id="84218872"/>
    <dbReference type="KEGG" id="fai:FAD_0374"/>
    <dbReference type="OrthoDB" id="371943at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000001">
        <property type="entry name" value="DNA gyrase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="entry name" value="DNA gyrase/topoisomerase IV, subunit A, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050220">
        <property type="entry name" value="Type_II_DNA_Topoisomerases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01063">
        <property type="entry name" value="gyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004043">
        <property type="entry name" value="PRK05560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004044">
        <property type="entry name" value="PRK05561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493:SF5">
        <property type="entry name" value="DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493">
        <property type="entry name" value="DNA GYRASE/TOPOISOMERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="GyrA/ParC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="8">
        <location>
            <begin position="27"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="425"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="791" mass="88838" checksum="025D034191C30AFE" modified="2017-06-07" version="1">MLLRPIEEEIKTSYLDYAMSVIVSRAIPDFRDGLKPVQRRIIYSMYELGVTHDKPYKKSARIIGETMGKYHPHGDSSIYEALARMAQDFSLRYTLIDGQGNFGSIDGDAPAAMRYTEARLGKMAEEMVRDIEKETVPFSPNFDGSLDEPVYFPSRIPQLLINGTSGIAVGMATNMVPHNLSEISDAIMYGIDHPDCSVEDLLKFVQGPDFPGGGMIYRNSDLLNIYRTGHGKVFCQGEIDDEEKKKIIIKTLPYGVNKALYIQNVAEQVKNGIISNISDIRDESDRNGIRVVIKIKNDDSKGLTINQLYEHTPLETTIGVNNLVLLNNEPKVMTLDEMILGFIDFRLEIIRKRSVFEVNKLMDREHILSGLVIALENIDRVIKIIRSSDNADMAKTSLMDQLSLSEKQALAILDMRLQRLTGLEIKKINDELISIKENIERLNEIINNESKRRDVLKQETLEIKKQFGDVRRTKVLNRDINARNDEDIIPNEESIMILSENGLLKRVSSEEYNVQKRGGKGTITATRKEDTVRSILSCMSHDMIYFFTNTGRVLRTKAYTIEKKSRTSLGSVGGTFLKMNENEKIKQIMKSPASPKNFLIIITKKGFIKRTPVKEILDMRESGLKIIKLDDQDEVVSVMDLEKPSKIFVAASNNKAAVFLSDEVSSTGRASRGVKSMRLNGAEVINSFLVDDNDTVMSITENGLGKRTKITDFSIHHRGSSGNLIFKESERTGSLVTALPVGDSQEVLIVTRNNKTIRLNSDEIKIQSRVTSGVKLINVDDDDLVVAASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2G9</accession>
    <name>A0A1V0N2G9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gyrB</name>
        <name evidence="13" type="ORF">FAD_0373</name>
        <name evidence="14" type="ORF">HLB00_00785</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Berkeley</strain>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000021">
        <property type="protein sequence ID" value="NOL59375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_171481185.1">
        <property type="nucleotide sequence ID" value="NZ_DAIDCF010000083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2G9"/>
    <dbReference type="STRING" id="74969.FAD_0373"/>
    <dbReference type="KEGG" id="fai:FAD_0373"/>
    <dbReference type="OrthoDB" id="358756at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16928">
        <property type="entry name" value="HATPase_GyrB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00822">
        <property type="entry name" value="TopoII_Trans_DNA_gyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000002">
        <property type="entry name" value="DNA gyrase subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000002">
        <property type="entry name" value="DNA gyrase subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000565">
        <property type="entry name" value="Topo_IIA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004189">
        <property type="entry name" value="PRK05644.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45866:SF1">
        <property type="entry name" value="DNA GYRASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45866">
        <property type="entry name" value="DNA GYRASE/TOPOISOMERASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01159">
        <property type="entry name" value="DNAGYRASEB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="433"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD84294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="NOL59375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="647" mass="72462" checksum="8CDFDAA17CA7745F" modified="2017-06-07" version="1">MDKAMDNYDASQIQILEGLKAVRKVPGMYIGSTGPDGLHHMVYEVVDNCIDEAMAGFGSDINIVIYKDGSISVEDDGRGIPVDIHPKYKRPGLEIVMTELHSGAKFDKKVYKVTGGLHGVGVHVVNALSDYLLAVVKKGNKIYYEKFKQGVPVSGLQVLDAKNKSADPEIGDIEMKYPEHGTIIKFYPDATIFDTIDFSYPVISQRIMDLAFLNPNITIELSDLRSGKHEKFHFDGGLVEYVQFLNQGKDIVNKEPIYCREEYKEYVVEFALQYIDNVTGTEESFVNNIKTPEGGTHITGFHTGLSRAVLEYAKAKNLVKGVSGLIGDDTREGLTAVLHVKMFNPQFEGQTKEKLGNSVVKSIVSSITEKYLKDYFESYPPIADAIIKRVLAAAIAREASRKAKDLVRRKTALESGTLPGKLADCSSSDSDQTEVYIVEGDSAGGSAKQARNREYQAILPLRGKILNVEKSNDNKALENEEIKNLITAIGTNIKDKFDIKNLRYGKIIIMTDADVDGAHIRTLLLTFFYRFMNELIQGGHIYFAQPPLFRVQKGNDIVYVFSEDEKDREVAKMGKNVVIQRFKGLGEMNPEQLWETTMNPESRKLVQVSIEDALYADQLFNILMGEKVEPRRKFIEDNAKYVQNLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2I2</accession>
    <name>A0A1V0N2I2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="4">P5C reductase</shortName>
            <shortName evidence="4">P5CR</shortName>
            <ecNumber evidence="4 5">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">proC</name>
        <name evidence="9" type="ORF">FAD_0380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4 5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141556.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2I2"/>
    <dbReference type="STRING" id="74969.FAD_0380"/>
    <dbReference type="GeneID" id="31675889"/>
    <dbReference type="KEGG" id="fai:FAD_0380"/>
    <dbReference type="OrthoDB" id="25257at2157"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="8">
        <location>
            <begin position="151"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="261" mass="28101" checksum="A42AC406AE0A0212" modified="2017-06-07" version="1">MKAAIIGAGTVGRSIGEGIKNDFEVSFSSGSFEKLEKWSKGEFKVFDNNVENAKYGDVILLAIKPGISDSVMEEIRSAAKGKLVISFMAGITLSHMQEMLKDSMVARGMPSIPMLVQKSVTAYSYKNLDKEHKDVLEKVLKGFGSAVHIDESYMDAVTGLSGSGPAFVAIMADSMINAGILAGIPKIQARELVIDTFINTMSLMREKGLSASDLRDEVMTPGGTTVAGIYEMEKANARTAIANAVLGSYRRAKEISKNSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2K6</accession>
    <name>A0A1V0N2K6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <ecNumber evidence="6">3.5.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0408</name>
        <name evidence="6" type="ORF">HLB00_05025</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141575.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2K6"/>
    <dbReference type="STRING" id="74969.FAD_0408"/>
    <dbReference type="GeneID" id="84218919"/>
    <dbReference type="KEGG" id="fai:FAD_0408"/>
    <dbReference type="OrthoDB" id="50279at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002284">
        <property type="entry name" value="PRK01211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="46"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="412" mass="46033" checksum="54AE80D794D4BDDC" modified="2017-06-07" version="1">MYDNVFSGKFFFQGSFQELDIGVESGIITDIKKHINHERKILKNAIIPAGTDTHVHFRDPGETEKEDFSTGSISALFGGTTTIFDMPNNRRKIDNYAAYSDKLAIVRRKAFCDFGLYSMFTGTNADIISSESSGIKIYMGETTNAHGTVDFTEKGIQKINNMNIPVLFHAEDGKCLEKHSGIAKNLKEYSATRPPECEDLAIDKAGNMKFSKGVITHLTHDFTTAYVKEVTPHHLLLNYDMPLGAYGKVNPPLRSRETQKELLNGLISGKFNIVSSDHAPHIQNDKVDFEYSKAGIIGVETRIPLMLALVQKKILPFDIFYKTCILNPALLFNLKKGEIKKGNYADFMSIDFSSMERINDYRLHSKNPGSPFNGFNGIFPSTVVMRGETVIDNGELVADRMGKYIKPAVDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2L1</accession>
    <name>A0A1V0N2L1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">metX</name>
        <name evidence="19" type="synonym">metG</name>
        <name evidence="18" type="ORF">FAD_0477</name>
        <name evidence="19" type="ORF">HLB00_08850</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Berkeley</strain>
            <strain evidence="20">Y</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000332">
        <property type="protein sequence ID" value="NOL60927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887532.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2L1"/>
    <dbReference type="STRING" id="74969.FAD_0477"/>
    <dbReference type="GeneID" id="16025681"/>
    <dbReference type="GeneID" id="84217060"/>
    <dbReference type="KEGG" id="fai:FAD_0477"/>
    <dbReference type="OrthoDB" id="30609at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000042">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF37">
        <property type="entry name" value="TRNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="17">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ARD84392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="NOL60927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="108" mass="12025" checksum="7C6A0A4BF82240AF" modified="2017-06-07" version="1">MEEISIDEFHKIDIRVGKVIECTKVEKSRNLLKIIVDLGDQQKQIISSISNCYSPEDMMGKQLVVINNLAPAKFMGLESQGMLLAVEDENGVSLLKPDREVSPGTKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2N7</accession>
    <name>A0A1V0N2N7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">H+-transporting ATPase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FAD_0498</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141637.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2N7"/>
    <dbReference type="STRING" id="74969.FAD_0498"/>
    <dbReference type="GeneID" id="31676007"/>
    <dbReference type="KEGG" id="fai:FAD_0498"/>
    <dbReference type="OrthoDB" id="8588at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000042">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000211">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="661"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="751"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="783" mass="86681" checksum="22FCF0E3A48C5CFD" modified="2017-06-07" version="1">MIKSSDSLEDLFKKLNTSKAGLSGNEASSRLHTYGYNEVSEKKESSILKFLKKFWTPISWMLELTIIITFILGKYDDSLIILFLLIFNGVISFTQESKADNAVELLKKKLSAQARVLRDGKWNVIETKFLVPGDIVHLRLGDVVPADIKIIDDELEIDQSALTGESLSVTRKKGDTIYSSSVVKRGECNGLVTETGSKTYFGKTTELVEIAKTKSHIEELIMKIIKDLIAIDTILVIALILFSIYRGVDITEVIPFALVILIASIPVALPATFTIAMSLGALHMSKRGEIVTRLSAIEDAASMDTLCMDKTGTITENKLTIKTPKVYTGDELSLIKYASYASQRKSEDPIDDAILDYADLKSVKIDYANRSKFTPFDPSIKRTEAIINEAGKSVKIVKGAPQVISELTGNVPETYENDIKYFSSQGFRIISVAAGTDKLEILGVIPLYDPPRKDSRDLITELKQLSVSPVMITGDNSLIAEEVAGEIGLDKKLCNAENIKGNYAGASDCSVFAEVFPEDKYYIVKALQKSGHIVGMTGDGVNDSPALKQAEFGVAVASATDVAKASASVVLTHSGLTDIVDGIKSGRRIYQRMLTYTLNKIIKVIQIVFFLTLSFFVVGFFVTTAFDVILLIFANDFVTMAIATDNVGYSIKPERWNVNSLISSSVILSAFLVVESFIFLYIGLYAGLRISQIHTFIFDMLVFSGQFTVYMVRERKRFFNSMPSKILLLSSIVDIIIISFISYYGILVTAIPLKFILISIGLTFIWMVFMDTIKNVVFRHYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Q9</accession>
    <name>A0A1V0N2Q9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="4">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FAD_0466</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887521.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Q9"/>
    <dbReference type="STRING" id="74969.FAD_0466"/>
    <dbReference type="GeneID" id="16025670"/>
    <dbReference type="GeneID" id="31675975"/>
    <dbReference type="KEGG" id="fai:FAD_0466"/>
    <dbReference type="OrthoDB" id="146558at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="106"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="425" mass="47311" checksum="E71FC8C8B117D13B" modified="2017-06-07" version="1">MNVLLVGSGGREDAIARKIRETDNLYSVVSNENPSILGLSRNVIKYNKNTQEIVNFAKKNRVDIAFIGPDDILNTDLVDSLIENHIPVASPGQKAAMIETSKEYMRNLMERHHIKGNIENKLISDKEVLKTFFENNDTEYAVKPIGLTGGKGVKVMGLQLSNVAEAIAYASEIIDRDGKVLLEKREIGEEFSIQAFTDSKNVVFMPVVQDYKRLYEDDLGPNTGGMGSISDKNFILPFLSIDVVNEARGILNDIVTAMREENNPFKGVIYGQFMSTAQGVRVIEINSRFADPEGINVLTLLQSNIVDIFLDIYSGTLKNNIKFKSKATVLKYIVPPGYGIKPVETELTIKDRIETDNFKVYYSSVSGTLNHVTTTKSRSLALIGIGDSIYEASDIVEDNLKYITGDYYIRHDIGTEAMIKGKIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2S4</accession>
    <name>A0A1V0N2S4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gatA</name>
        <name evidence="2" type="ORF">FAD_0540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141660.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2S4"/>
    <dbReference type="STRING" id="74969.FAD_0540"/>
    <dbReference type="GeneID" id="84217138"/>
    <dbReference type="KEGG" id="fai:FAD_0540"/>
    <dbReference type="OrthoDB" id="7931at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="439" mass="48745" checksum="C3439E120DD63EA4" modified="2017-06-07" version="1">MIPPIHTLHDLIISGEISPYHLFKKSAENISHLNPDINSFATLRPFNEPTIHKHSSSPLYGIPYSVKDIIDTKNLRTEYGSEFFKGHVPQEDADVIRALDEYGPVLQGKTNTHEFAMGIVTPVCNNPWNVSKITGGSSGGSAAAVSSGLSLFSLGTDTAGSIRIPSSMCGVSGLKPTTGSLSVKGIFPEAWSLDTVGPITRYASDIPAIVTAMGFKSPRAKSQRRKPLLGIIGNLTESSDTNVKFAFYSFMDHMVSEDLVDIKEIHIDNMESMASAADMIDGCENATIHRSRYENNPELFSVESRNQIKYYSSLKPMDYIEAKRLRMRQGMEFNSLFNQYDFLVSPTLPTIAPDKKEIENVPFDYFMKYIKFTNPFNLFGVPALSIPCGFSRDMPVGLQIVGGKLRDIEVCNLASRFQEITDFHTRIPPIAKNINYFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2S5</accession>
    <name>A0A1V0N2S5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0483</name>
        <name evidence="5" type="ORF">HLB00_08820</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000332">
        <property type="protein sequence ID" value="NOL60922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887538.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2S5"/>
    <dbReference type="STRING" id="74969.FAD_0483"/>
    <dbReference type="GeneID" id="25398815"/>
    <dbReference type="KEGG" id="fai:FAD_0483"/>
    <dbReference type="OrthoDB" id="43754at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="149" mass="16924" checksum="5A0A9BA2BE96FBE7" modified="2017-06-07" version="1">MQVRPYRKSDFHGVSIIEKMAFGDEAYSNFMLKGILNSINGFTYVLDDGSKLHGYATMGPLNEQAIDIESIGVLPEDQDMGYGSMLITAIEAEARARGYSIIILEVREKNDHAIKFYKAHGYETFELINGYYSMPFNGSRNAYRMRKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2T5</accession>
    <name>A0A1V0N2T5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141633.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2T5"/>
    <dbReference type="STRING" id="74969.FAD_0493"/>
    <dbReference type="GeneID" id="31676002"/>
    <dbReference type="KEGG" id="fai:FAD_0493"/>
    <dbReference type="OrthoDB" id="36362at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="2">
        <location>
            <begin position="236"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="607" mass="69509" checksum="38E55979D2B413DA" modified="2017-06-07" version="1">MGTYRGLYDLHDAYRSDYLKIANHGFIANNRTAALVGIDGTIDWACLPNFNSNPVFDSILDARNGGYFKTSPVMESNVNQYYEESTNILITEFVNNNQVILRLTDFLPTSSYSTITFPEIHRLIEAPYSDVEVSIDIKSHFNFGSGKTNITRDRNGYIFSCTDDTLGISTNLKLKKGNGNVYSRIKVEKGSHEWIVVLSGVRQIGNVRQYESYTRLEETRNYWSAWAGKINYSGLYYDHVIRSALTLRGLFYDPTGMMVAAPTTSLPEIIGGERNWDYRYTWIRDTAYVVEALSLIGLKDVATKFLYDIMSIVQKDKKVKTIYPVNGDSKLEEKKVNLSGYMDSIPVRIGNEASEQLQIDQYGSIVNAVFRFHEAGGLVTTYLWDFLIEILDTLKDIWKLPDSSIWEFRSEPKHYLYSKLISWSAFNRAIKMGRELGYSAPYRTWHKIREEIKNEIMEKGYNPDVKAFTQYYGSDQMDASVLRMPLTGIISAKDPRFVSTLARVEAELKNPCGMFIRYHSDDGLKGHDNAFLLLSFWYVEDLILSGRIMEAKETFENILDHSNHLMLFSEEINFNDCREMLGNFPQAITHLGVIRAAIKLDEALRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2V3</accession>
    <name>A0A1V0N2V3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141650.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2V3"/>
    <dbReference type="STRING" id="74969.FAD_0520"/>
    <dbReference type="GeneID" id="84217103"/>
    <dbReference type="KEGG" id="fai:FAD_0520"/>
    <dbReference type="OrthoDB" id="6995at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="98" mass="11033" checksum="0184E8CAF6CF50B7" modified="2017-06-07" version="1">MSTESEPPSEKPVTAIVDVFVDTTKIEDVVNELCRLDRVEEVYEVTGEFDIATVISSRNIEDFRDFLKNKIMKIPGIKSVVSSIVLTSDKGPRSDRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2X7</accession>
    <name>A0A1V0N2X7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13 16">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="13">NDK</shortName>
            <shortName evidence="13">NDP kinase</shortName>
            <ecNumber evidence="3 13 16">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ndk</name>
        <name evidence="18" type="ORF">FAD_0592</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14 15">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 13 16"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887649.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2X7"/>
    <dbReference type="STRING" id="74969.FAD_0592"/>
    <dbReference type="GeneID" id="16025799"/>
    <dbReference type="GeneID" id="84217191"/>
    <dbReference type="KEGG" id="fai:FAD_0592"/>
    <dbReference type="OrthoDB" id="6874at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000003">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8 13 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="17">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="13 14">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ARD84503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="139" mass="15456" checksum="3C6851106AE7A0EA" modified="2017-06-07" version="1">MERTLVLIKPDGVKRHLIGNIIERFENKGLKIVSLKLMKVSDDKARQHYSVHSMKPFFEGLVSYLTSGPIVALILEGDNAIISCRNLAGATDGSAAAAGTIRGDFSLNIEENIVHASDSPESFNHEYKIFFNENEIMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Y7</accession>
    <name>A0A1V0N2Y7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141679.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Y7"/>
    <dbReference type="GeneID" id="31676053"/>
    <dbReference type="KEGG" id="fai:FAD_0547"/>
    <dbReference type="OrthoDB" id="56549at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28046" checksum="D28E4C60AACCEE8E" modified="2017-06-07" version="1">MVNELIEKNKPYYIKSLSLEDQFSRLDAWYKVDFLIDNNILTKEYVIENKTKFLDLLTTTDEMVKVHAWVLARRFADAGYISKEDIDKRKSYLIPYVKSGDLTAWWNAIDLVNGGYIDNTYLTPYKDIFIASLKSDNPGVVSDAWHMVPLLLKAGVISNADYDDNKKYLFNVLKSSNQYIRLNAWETIIDLGEKGILTKEDIFPFKSKAKELIEGEDLIKLTSLFDTSKDDFIARLKNLDLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N320</accession>
    <name>A0A1V0N320_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase chain 5</fullName>
            <ecNumber evidence="2">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FAD_0627</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887685.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N320"/>
    <dbReference type="STRING" id="74969.FAD_0627"/>
    <dbReference type="GeneID" id="16025834"/>
    <dbReference type="GeneID" id="31676132"/>
    <dbReference type="KEGG" id="fai:FAD_0627"/>
    <dbReference type="OrthoDB" id="371891at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010934">
        <property type="entry name" value="NADH_DH_su5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
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    <sequence length="627" mass="69791" checksum="DFF31101F2421F51" modified="2017-06-07" version="1">MVSIYYFIFLLPLFGFPLEYIIGKYRLKYSGIFSSVMVLGSLILVILAYLYLLHHNFIYSHYTWFYNIDVGIYISHLTVIMAMMVAFMSLMITLFAMFYMKDDPRKNIYFSETSLFIAGMLGLVVSSNLVLFFLFWEIVGLCSYLLIGFWFFKPNAAAAAKKAFIVTRVGDLLFIIGMGVLFAKLVNIVPAGTSPLSIPYLIDNAQSIASAIGPDVLALATILFLAGAVAKSAQFPLHVWLPDSMEGPTTVSALIHAATMVTAGVYLVARLFPLFYYSASFSLYAVAIIGSFTAFYAGILAIVVNDIKRVIAYSTISELGYMMAAIGLGGVIGYSGVTFGMYHLVVHAVFKALLFMSAGVILVMLMELRNIKDMGGLFRKMPVTAILMLIGVVTLAAIPPTAGYFSRDQIISGAYEYFVNSGNIIPWLLLVFGEILTAIYAFRLYFLVFAGKPRSKLAEKAHDPKLIYLVPLMVLAFLSLTLGIIQKPFYTFLDSSVKIYSPPFIIAAIPVIFSFLGIAIAYAIYRYNVKGYTNITKNPLYKIIKNKFYFDWLYTEIISERIILPISYLIGVAERKFNDRIDSAGKDISDIGTDFRKIETGDIPFYVAFLIIGMIVIFAIIELIGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N327</accession>
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            <fullName evidence="4 5">Small ribosomal subunit protein eS28</fullName>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
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                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">Berkeley</strain>
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        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ARD84501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60184.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="69" mass="7506" checksum="162DAB9671FC0909" modified="2017-06-07" version="1">MADDATPAEVVELMGRTGMTGEATTVKVRVLDGKDQGRIIARNVLGPVKVGDILMLRETAREARRLSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N334</accession>
    <name>A0A1V0N334_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N334"/>
    <dbReference type="STRING" id="74969.FAD_0594"/>
    <dbReference type="KEGG" id="fai:FAD_0594"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="6">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="6">
        <location>
            <begin position="148"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="260" mass="28664" checksum="F872F8206FD32896" modified="2017-06-07" version="1">MAGDIFLDVSYSVGKSFSFSEKYVGLFIVGFAAIVDEIAMSVMAAVENQGAVSFGTIQGSNAITLLAFFILIPLYYKSGISKFRLDAYVVTATAIILLILSFYFIKVPYYIGFITLAVFLFYVIKKSKSPGSKNVIVAEESYPSYFGILAIIVIVLASYNMIDAALIISEVLKITAFLSSFFLLGFFGSLPEIIMLSISLKDKRKNVSIGLITGSTLYKETILFSIIAFIGTLTFQDSFFSLILMMIFSVVLIIYTFIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N337</accession>
    <name>A0A1V0N337_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AIR synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0598</name>
        <name evidence="5" type="ORF">HLB00_10085</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000443">
        <property type="protein sequence ID" value="NOL61166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887655.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N337"/>
    <dbReference type="STRING" id="74969.FAD_0598"/>
    <dbReference type="GeneID" id="16025805"/>
    <dbReference type="KEGG" id="fai:FAD_0598"/>
    <dbReference type="OrthoDB" id="31494at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06061">
        <property type="entry name" value="PurM-like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303:SF4">
        <property type="entry name" value="HYDROGENASE EXPRESSION_FORMATION PROTEIN HYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="HYDROGENASE ISOENZYMES FORMATION PROTEIN HYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="3">
        <location>
            <begin position="154"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL61166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="343" mass="37936" checksum="B2483BE27EECEF28" modified="2017-06-07" version="1">MIGKISRKFFEENIINKIGTLRDEVVVPPKNGVDVGIVKIGDKYMAVTTDPLYIDKSFGFKKAAWFAFHILLSDLYTSGIPASYMSIDLNLPSSITDNEFKEIWDVINEECIKYNIEVVTGHTARYNGVEFPMVGGITLMGTGEKFITTENAGVGDRIIMTKSCALETALILSNTFPEYVRNNIGEENYKSIIGKFYTMTCVGEETLAIEYGISERITSMHDATEGGLLNAIYEIGIASGNGLSVDYNKIIIDSDIEKLCNLFNIDPLRSISEGTLLITVKEQYAMEFLTILQSSGIEASLIGEILDNSKGIKILKDGKQEDIRPEDDQLWGAITKGIKDGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N365</accession>
    <name>A0A1V0N365_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamyl-tRNA(Gln) amidotransferase subunit D</fullName>
            <shortName evidence="5">Glu-ADT subunit D</shortName>
            <ecNumber evidence="5 6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">gatD</name>
        <name evidence="9" type="ORF">FAD_0616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the asparaginase 1 family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5 6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141729.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N365"/>
    <dbReference type="STRING" id="74969.FAD_0616"/>
    <dbReference type="GeneID" id="31676121"/>
    <dbReference type="KEGG" id="fai:FAD_0616"/>
    <dbReference type="OrthoDB" id="371959at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00586">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011878">
        <property type="entry name" value="GatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037222">
        <property type="entry name" value="GatD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02153">
        <property type="entry name" value="gatD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003217">
        <property type="entry name" value="PRK04183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500175">
        <property type="entry name" value="Glu_ADT_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141300">
        <property type="entry name" value="GatD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="7">
        <location>
            <begin position="73"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="8">
        <location>
            <begin position="280"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="402" mass="44638" checksum="5E53834A76D42393" modified="2017-06-07" version="1">MLIGQKIIFSYKGEEYAGTYISSGKNTITVKLGSGYNITVDASSIEIKKEYSMEKGDKPGAETKNSGCGENGVCILTTGGTIASSVDYTTGAVKPVKDISYLYNFVNNISQFKLYHESIDNILSENVNAEKWVQFARKARDAMKKSNSVIVFHGTDTMQYSASALSFMFEEQTEPIIFTGSQRSSDRPSSDAFLNIEGSIHFASTDMGEVGIAMHTDTSDDSISLYRATRARKMHTSSRDAFKSISEPPLGLYADGKVKEIKNIRHKSDSIILKDRLDKNIGLIYFYPGMAEEDFYNLSYNKKAVIIMGTGLGHTSTGIIDVIRKLSRETHFFMTSQCIYGNVNMNVYSTGRELIDAGVIPLQNMLAETAMVKAMYLSANYPDNFVELMQKNLRGEFEDTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3D0</accession>
    <name>A0A1V0N3D0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thermopsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141782.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3D0"/>
    <dbReference type="STRING" id="74969.FAD_0679"/>
    <dbReference type="GeneID" id="31676180"/>
    <dbReference type="KEGG" id="fai:FAD_0679"/>
    <dbReference type="OrthoDB" id="36243at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007981">
        <property type="entry name" value="Peptidase_A5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05317">
        <property type="entry name" value="Thermopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="748" mass="81914" checksum="27027F8AC846AC0F" modified="2017-06-07" version="1">MKKLLAIVVAIIFVALAFAVVASQGTTVPSATADVSHQSVQQNSDSRLLAIEKKLEEKGIPLKYASIPAFYNNITRDNGVVAPSYSSAPAPMGIGFYGTKNVSGKLVGYNLTTPSVMASIGIKNMSQFYLLNDGPTSETFQLNSVLTNVTLFGNSTYTFWTQNVAFYSERTQTIQFLTNIWNFSSPAVAISSNVFHSYDGILCAPTFYYAIGPTIHVTTPFSLNLYLNSTVVDRDSAVFFNYSIMSDNHIQSGSYDYAIFNSTYGQPSTFTAKAPEYLASGTQVTPTGFIPYDFEIMVGGPGGGSTTSIYNVNATMNLMYKGSKGYVNVPSAYDVGSETGETSEGVAVSWANDTAYLTPGPSFVYGMWNISGSNAMTHYSGMVAPSNAFMFISEGNTFNASNAQWAPLSLSGKYSFTLPTGQYTAQALLSNYMNAYFMPGQNVSLMHDYSMGIYTPLYAFDNAQIANISLYGNGTAGNPYVMDNYQVMPISSLFEEFNDYAFPVFAGVLLHNTNASVVMQNMPSLYIPYTSTNPTYESYVSFYDLPGYNYLNYELYNASNVTLWKSNDISGYFASGVSGFPVANLVIWNSTNDLVGSNMFNVMDSGMLIYKSPYVTVWGNYVINAPQTYKSTFEQVTDIWGAPLGIAEYSSGDTIYNNFFDTAITAYSPNTSIYSGNPAVYINMWNITKQPAYITHYVNGFALSGSIINTHYQGGNYWNNFNGTIPYNNNGLIAYGGDYVPLYHGLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3D7</accession>
    <name>A0A1V0N3D7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0705</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3D7"/>
    <dbReference type="STRING" id="74969.FAD_0705"/>
    <dbReference type="KEGG" id="fai:FAD_0705"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="224"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="430" mass="48115" checksum="39303B002CCBDE4D" modified="2017-06-07" version="1">MDISENLRKSLGLMKFTEPTEIQEKAIPVVLTGKDVIIRSKTGSGKTAAYLLPVLNSVEKLKGKGVKAIIILPTRELALQTHRVASRLGKISGIKSTIVYGGASIIRQVEELPGSDIVIGTPGRILDLYNQKYLKLDHVKYLVLDEADLMLDMGFIDDIKKIISFTPEGRQTILLSATLPAEVKTIANHFMNNPEFVDAGGDEAIPSSIKHLYTVSEKFDKFSTLMSYIHSYNSRKAIVFVKTQRSGDLLNLILSRSGFNNVLIHGGMKQHARERSIADFRHIDSGILVATNVAARGLDIPNITDIINFDAPESTETYAHRVGRSGRMGKDGRAMTIFDPSQKSLIQSIQRRNRIKMEKINIDLETEYTDINYGKLIAQFRDNEENAPEPDYHSRGRRPSGGRDRRPSSRRETGSRPGRSSGNYRRREHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3F8</accession>
    <name>A0A1V0N3F8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-carboxytetrahydropterin synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">6-pyruvoyltetrahydrobiopterin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptps</name>
        <name evidence="5" type="ORF">FAD_0725</name>
        <name evidence="6" type="ORF">HLB00_01135</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000031">
        <property type="protein sequence ID" value="NOL59441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141850.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3F8"/>
    <dbReference type="STRING" id="74969.FAD_0725"/>
    <dbReference type="GeneID" id="84217348"/>
    <dbReference type="KEGG" id="fai:FAD_0725"/>
    <dbReference type="OrthoDB" id="6529at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="157" mass="17877" checksum="E6DA41155BEF6523" modified="2017-06-07" version="1">MYRIEVVGALKGLTWSSGHYVPDNEKCKNFHGHDYSIDVIIDSDGVKSSGMAIDFTIVKQAIKPVIEDMDHKFMIPEDDIRQNENPGFIDIYVRGKYRGTMSRSDIFAFPYSADTAEFIAKYCYDKIFAKLLGLMENFRLKVTIHEGPGNMATYSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3H0</accession>
    <name>A0A1V0N3H0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141853.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3H0"/>
    <dbReference type="STRING" id="74969.FAD_0729"/>
    <dbReference type="GeneID" id="31676231"/>
    <dbReference type="KEGG" id="fai:FAD_0729"/>
    <dbReference type="OrthoDB" id="25239at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="2">
        <location>
            <begin position="123"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="317" mass="35728" checksum="2914A231BFA0E360" modified="2017-06-07" version="1">MKILVVGANNFGQKHLSGIKGMEISIVERKPEVIEKTVEKFKIENVYSSFEDAIKDRFEIVDLVVPHYLHKEMAIKAMEAGSNVLVEKPIATTLDDGEAMIRASKDYGVKFMVTDQYFFDPSVRAAVKFIRENRIGRINTIIVRDQRFFEHGGWRTDKDQMGGGALIDGGIHFLDTLLNFGGNYESIHGKSIHGGSILNGEDNTAALFKFENGTYGLFFYSWSYRNPPELPAFEIIGEKGSIYEDVKSRTSWEVGTPVRTVYGDLIVNGENANVKKYDVYTAEIMEFADSVKNNTEVPFPPELALRDLKAVLDIYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3H2</accession>
    <name>A0A1V0N3H2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">APC family permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine/organocation superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0802</name>
        <name evidence="8" type="ORF">HLB00_00270</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000009">
        <property type="protein sequence ID" value="NOL59273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141993.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3H2"/>
    <dbReference type="STRING" id="74969.FAD_0802"/>
    <dbReference type="GeneID" id="31676304"/>
    <dbReference type="KEGG" id="fai:FAD_0802"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="18"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="471" mass="50967" checksum="752E89BC38A02F5F" modified="2017-06-07" version="1">MVEVDQLKRNSLGGFRLVWQAMGTLSVAADAAYLLTGVVEYALGATPLALLLGVFAYLFIMNTGYQFSKHVNSAGSYYTFAGKGLGGIAGTFQAWNMAFYGLIGYGSFGFLGLAAFITLLDPAYKGIVFWLPVAFFAALISFIFTHRGMKVSTDYQITGGVIEVAVLLIGSALIIIHAGNLNTLAVFTTKYVSGASQLLFAMIYSMILYFGTTVSITAMGEEAVSPQKTIKKALIGTVILSGITLIIVSYAFTIGWGPSAMASFATSPDPGIILFRKLNPVIYILLILVTVNSFMGYNISVSNADSRIFYSFARDGILFLPESIGRIHKKYKTPSNAALAIFAFSLVIAIIFGVLFGPVKGGLMMLLINAYAAYVEHIIASISLPVMMRRIHKFKVIEHLIIPVIGIVILVIIMAGTVISPGKYPENLAVYIGISWIPIAGILTFIEYKIHPDKVRNAAKMSIEEEALEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3L1</accession>
    <name>A0A1V0N3L1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nicotinamidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142030.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3L1"/>
    <dbReference type="STRING" id="74969.FAD_0828"/>
    <dbReference type="GeneID" id="31676329"/>
    <dbReference type="KEGG" id="fai:FAD_0828"/>
    <dbReference type="OrthoDB" id="9194at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="180" mass="20201" checksum="E6491B6F25178D94" modified="2017-06-07" version="1">MDKTKSCVLVVDMINDFVTGKFGDSNAVESVKLAEIALKQLKGNIPIIFAKDSHIKNDPEFKVWGEHAIDGTWGSEIVDALKPFPDYILKKRHYDAFFDTDLDSLLRASGIANIYIFGISTDICVEHTCAAAFYRYYNVKVISDLCACIDNSHQISALTNIKINYGYTHINSEELLKEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3L4</accession>
    <name>A0A1V0N3L4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase class-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0851</name>
        <name evidence="3" type="ORF">HLB00_04555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000155">
        <property type="protein sequence ID" value="NOL60106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_171481542.1">
        <property type="nucleotide sequence ID" value="NZ_CP133600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3L4"/>
    <dbReference type="STRING" id="74969.FAD_0851"/>
    <dbReference type="GeneID" id="84217476"/>
    <dbReference type="KEGG" id="fai:FAD_0851"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42824">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42824:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YAFJ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="232" mass="26843" checksum="3F7D76092B2310F7" modified="2017-06-07" version="1">MCRMFAYKGNSQEELNNLYNALKESARNDTIGSKFGYANHPDGFGYVIYNGQNIYYYRSENPIYEENVKLPEVTGDMYAIFLARKASGKKHMGVMYSHPFMDDYSNNLIYLAHNGSVSEDELKKELNYRYDASDSELALKYISKYGINSDTINNLMKNYTTSSLNLLMLSISKTDKKRSLYYLNYYINKDKHEYSDMYKVHLTHGDAVISSTLRLHGINTDEKVPFGKLMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Q4</accession>
    <name>A0A1V0N3Q4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">APC family permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine/organocation superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0805</name>
        <name evidence="8" type="ORF">HLB00_00255</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000009">
        <property type="protein sequence ID" value="NOL59270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887907.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Q4"/>
    <dbReference type="STRING" id="74969.FAD_0805"/>
    <dbReference type="GeneID" id="16026025"/>
    <dbReference type="KEGG" id="fai:FAD_0805"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="477" mass="51041" checksum="EB043806FAAA0316" modified="2017-06-07" version="1">MERISEGRTLKKGAAGFYSLLGQSIAMISPLGAVAATMTGAAEFAKGSLPLAYIISIFGVLIWINTPYQFSKKINGAGGFYTFNSQGASPTYGLIIGYMMWFSYFMVITNAILFTSGVFIPGTISYFLHFNIGSYTWIPIMTAFIVILTVIAYLGIKPSLAYSFTASVIEIALLVITSVVIIVALGSKNTYVPFTAGPADGFAAVAVGMVLAIFSMSGSSAVVTLGEEAQQPRKNIKKALLISFIITGVVFVLTSYALTVGWGVSKMSTFFTSSVPGLIVSDKYLGLPFTIVLFVFIINSLFAGSLAPLNTSSRMIFSMSRDGLGPSMFSKVHPVHKTPYIAIITMAGVAYVVSLAAGLLIGPEDGFLYLVTASSAALFVGHILSNFGLGVTYKKLKEFKILTHAVIPAIATVILAIAMFYSFVPPAYPVDYSIITAVVFIIISAIAIVIYAIKHPEAIKRAGSTDMEVQNDIYREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3R9</accession>
    <name>A0A1V0N3R9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142141.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3R9"/>
    <dbReference type="GeneID" id="31676399"/>
    <dbReference type="KEGG" id="fai:FAD_0895"/>
    <dbReference type="OrthoDB" id="134886at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295:SF8">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="41"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="235"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="417" mass="50405" checksum="1716ECC9D9FCC0CE" modified="2017-06-07" version="1">MDVSDIEKFNDWWITGRVRPALLKNFKREIYNEINKYMENRLMILLYGLRRMGKTTIMYQLIDELLNKTDSKNILYFSFDDTNYDLDDIMEVYQNNIINKLFNNTGEKIYIFLDEVQKLKDFENKIKVYYDLYPDIKFILSGSASISIRKRSNESLAGRIMSFYIEPLSFPEFLEMNNFNIEEIKHNYILYKNEIMPMLDIYSKYGSFPELALNRDDDYARKYIKETVVERIIYKDIVEEFKVNDLTLLRSLINVIANKPGMMLNFRSISENLGKDQRTISNYFEYLEYSFLIRIIYNYRENISITMRKLKKCYPITPNIVFALSDKFNDLYPYIMENLVLMKIKTDYFYRNNYEVDFIEVHEEKIKAIEIKKTDREMKQLKLFTKKYENVEPLMVTYDKEEHDDINVMPLWVFLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3S9</accession>
    <name>A0A1V0N3S9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA superfamily ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0850</name>
        <name evidence="4" type="ORF">HLB00_04560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000155">
        <property type="protein sequence ID" value="NOL60107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951109.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3S9"/>
    <dbReference type="STRING" id="74969.FAD_0850"/>
    <dbReference type="GeneID" id="31676350"/>
    <dbReference type="KEGG" id="fai:FAD_0850"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="310"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="455" mass="53591" checksum="853F893B7065C990" modified="2017-06-07" version="1">MIQQFINRKYELNFLNKKYDEDKPQLIIIYGRRRIGKTELIKEFISGKKTVYHLCTADSIEENITYLKSEFSSITGKSYFLNLEVDLFTLFKYLIDEIKDEKIIIALDEITYLVSLNKGILSIFQKIYDELMVNSRLFIIFSGSSISMMEDEILNFKSPVYGRRTGSLEISGFDPNLIEYFYPGDFEDIVKIHSIFGNVPFYLSLIDKNQNIEWNIKNIILSKGEILYEEPKILLKEEFREPRIYEMILKRISEGKNTYGELQNALHLDSGNISRYLETLISSRFIKYIIPLNQKRRGIYEINDYFLNFYYKFVDPNRSDLELGNIESVFKKINNNLNTFYGHTFERIALEMVSRGIIPIPIHNFQVNKFWHKDVEIDGVATNDKNDVVFIEIKFVPDVDGIKIYNELKYKSLSVNIKRNKEYYMIIAKSFKTKSNEAINVDFADINKIIKKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3T6</accession>
    <name>A0A1V0N3T6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein FAD_0916</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142180.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3T6"/>
    <dbReference type="STRING" id="74969.FAD_0916"/>
    <dbReference type="GeneID" id="31676419"/>
    <dbReference type="KEGG" id="fai:FAD_0916"/>
    <dbReference type="OrthoDB" id="59443at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.70">
        <property type="entry name" value="Hypothetical protein apc22750. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145_YbjQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068:SF2">
        <property type="entry name" value="UPF0145 PROTEIN SCO3412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="UPF0145 PROTEIN YBJQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="YbjQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="116" mass="12050" checksum="4379D05D615D4DFD" modified="2017-06-07" version="1">MTNIQDVITVTTPEVSGMIVVRTIGTVFGIVVRSRGLGGNVVAGLRSLAGGEIKEYTAMLTEARTHAVGRMKANASELGANGVVAMRFDSSEIGQTMSEIVAYGTAVVLEPVSGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3V4</accession>
    <name>A0A1V0N3V4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3V4"/>
    <dbReference type="KEGG" id="fai:FAD_0859"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217:SF7">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11543" checksum="5895ABE136ECE3AB" modified="2017-06-07" version="1">MRKQKGINASKYERNSNRKDYRNEYKLRSLLTTDGKVLLNKPQFRNKPFHTAVFDNYSRVENAVESVILESYLTGVSTRSVNRVVQSLVICSPKIWTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3W2</accession>
    <name>A0A1V0N3W2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142102.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3W2"/>
    <dbReference type="STRING" id="74969.FAD_0872"/>
    <dbReference type="GeneID" id="31676376"/>
    <dbReference type="KEGG" id="fai:FAD_0872"/>
    <dbReference type="OrthoDB" id="44002at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="554" mass="62921" checksum="B958892C2476B657" modified="2017-06-07" version="1">MFSNLRERIPQYIRDHKKDFLAFSIALAFFIVFSIFSILQYYSLGTSALDLGINAQSLYTFIHEGMFYSPLLGENTLAQHFTIFKFTQVPIYYIFPSPLSLMIYEDFFIVMGGYIVYLLSMELLKDHIKSMKLLYLVSIGFLLAYEFSPFTESLISFSFHNMAFLPFFFLLAFYAFLTERRVLQIISLAFIISLHANFIYIVAILLLYEFLFLHTSRGKKIGTWLSAKSKPTGIKNFSYFIIFIAILYVYLIFADFMKADISGVSAFSALPTTGEVGTPVSSPFALLLLLFHNPGEFSSIIGTNAGVKIFYLNLLFKSNIYLPLFSPLSLILLLPYIMYAVPSSYAAYYQLGYQYSAMVSGAIYISAIIGTYNVISFGKYIYRHNKSIRLRAKKVSAKIHNNNIWIPVISILIIVVLVISIPFGLLSPPGMQHTDHSTMNDIFEQNSGGAASFLINVSSNLPPNSYILTQNSLMPYFSNDINAYSTPWSPGYYNILPEFRYVVIQNNSFWATQGENHSLQIIVNNGLMNGNYTIINRYSPANIMILENTHNMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3X0</accession>
    <name>A0A1V0N3X0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142264.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3X0"/>
    <dbReference type="STRING" id="74969.FAD_0970"/>
    <dbReference type="GeneID" id="31676469"/>
    <dbReference type="KEGG" id="fai:FAD_0970"/>
    <dbReference type="OrthoDB" id="6396at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18012">
        <property type="entry name" value="DEXQc_arch_SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="DUF3670"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="550"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="837"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1015" mass="114261" checksum="12A980F62DE3BB45" modified="2017-06-07" version="1">MKDSKTLNVRLEETGSIIVLHGSCHVEEKGISFFLWSESTGTKIKDSAIHPFSGTSKVAANAVKKIWGNKINLKNETLSAIFPTSLDQPLVSGELSGIVSNENENDTFSYMEWHINGISVNITDVFLMLLKLSNNIINGIIIGDDLKFWKLAASSAFNLLTQQKFIPSATEEGTTIKSRWLPILETYEDQSLIYELSKNMPGVCLAFNHMEIDRETMLRMFISEIVDSISRRFAYQPGKPVKGSVGDAAKWVNSLSLDNPFVTYGRSLAMQKLVSWSEKIKSTLNFPFRTCMDLIPPENNGQWFLKFFLQSKKDPSLMVPYGKIWDRKDSETISLINKYTAFPEEFLLRSIGIAQSIFSPIGKNITSKPDGVYLSDEEVFDLLKTYSSSMEEAGFGILFPEWWGKKENKLGIKIKVKAGDINNSVKLGINALLDYSLDIVLNGEPVSKSDLEKLANMKSHLVQIGNKWVEIDNDQLNKILKLLDKGNKKMSLPELLTMENSNSIPVVEISGEGWVGDIISGNAKTLPIDEPENFIGNLREYQKHGVAWLKFMTGAGFGCCLADDMGLGKTIEIIAFLLDRLENNGSTSLILCPTSVISNWEHEIHKFAPSLNVYIHHGNLRKKDDNFIDNITDYKIVLTSYSLLQRDIKFLSQVNWDGIIADEAQYIKNYSTKQSRAIRSLQGNFKIALTGTPIENRLQDLRSIFEFINPGYLSGEKKFRETFSIPIERYGDENAMNALNTLVNPMILRRVKTDKSIIQDLPDKEEVKVYIPLTGEQASLYEAAVNTMLESVNTKKGIERKGVILSTITKLKRLLDHPSLVSGDLDRRLNRSEKLVRLREMLEEAIDSNQKTLVFTQYTDAGKIIKEEMLKKLGEEALYLNGSTPMSLRQNMVERFQDPDGPKIFIISVKAGGAGINLTAATNVIHFDRWWNPSVEDQATDRAYRIGQLKNVHVYKFISTGTIEEKIDDIIEGKSMLREKIIGASDESWITGLSSTDLKNVFSLRREVIASGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Y1</accession>
    <name>A0A1V0N3Y1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951117.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Y1"/>
    <dbReference type="STRING" id="74969.FAD_0893"/>
    <dbReference type="GeneID" id="31676397"/>
    <dbReference type="KEGG" id="fai:FAD_0893"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="95" mass="11271" checksum="63FD2C115F9340C9" modified="2017-06-07" version="1">MVNNENFNFLLQYFNEDEFINQCITENPDNYYNEISRYHAILKINVNNKTLYFSVVFALISAKSGYFEIITMFPDRTGDNKKYIEINGNDICKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Z9</accession>
    <name>A0A1V0N3Z9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ASCH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142220.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Z9"/>
    <dbReference type="STRING" id="74969.FAD_0947"/>
    <dbReference type="GeneID" id="31676451"/>
    <dbReference type="KEGG" id="fai:FAD_0947"/>
    <dbReference type="OrthoDB" id="84651at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="119" mass="14171" checksum="37E0540E487D38E4" modified="2017-06-07" version="1">MKVLLSIKPEYVNKILIGEKKYEFRRKIFKKNVKHAYIYSTSPVQRITVSFKIGKIIEDSPETLWSEYKEYAGISEESFFKYFENCSTGYAIEISMAKKLKDKKLKNRPPQSYYYVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N413</accession>
    <name>A0A1V0N413_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Csc2 (Cas7)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cas7</name>
        <name evidence="1" type="ORF">FAD_0943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142212.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N413"/>
    <dbReference type="STRING" id="74969.FAD_0943"/>
    <dbReference type="GeneID" id="31676447"/>
    <dbReference type="KEGG" id="fai:FAD_0943"/>
    <dbReference type="OrthoDB" id="56442at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017574">
        <property type="entry name" value="CRISPR-assoc_prot_Cas7/Csc2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03157">
        <property type="entry name" value="cas_Csc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18320">
        <property type="entry name" value="Csc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="319" mass="35709" checksum="E9F7C635BE01C18D" modified="2017-06-07" version="1">MNGKMDGKMNEIIKKGLLVKTENLDLKKNHGIYIKIGIVSETTGFLISRNNEATELTSENIYGDERCLVPAQKWRAAERSYLLSELRKVNGIIPPEYSRNMNKSKAPLKNPTSLLFGDSSIGSGDNMGSIASRSFYDWAYSFEPSGEISTRLTHNTLSEDGTILHNSNGKTESNAIYSIPYIKPGVKFIRFISLENCSLELLQLQLIAILGTTRYGARTAILGDNVANHIISIGFSKGEKPISSYSILSKDWETSEYNPENDVLQSMKESYGEDNILAGDELTSFLKDTWDIKSSSESLIALCETLNVKMENDWQEFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N416</accession>
    <name>A0A1V0N416_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mannonate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">uxuA</name>
        <name evidence="11" type="ORF">FAD_1019</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the dehydration of D-mannonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:20097"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17767"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mannonate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142350.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N416"/>
    <dbReference type="STRING" id="74969.FAD_1019"/>
    <dbReference type="GeneID" id="31676518"/>
    <dbReference type="KEGG" id="fai:FAD_1019"/>
    <dbReference type="OrthoDB" id="39900at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042840">
        <property type="term" value="P:D-glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="MANNONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387:SF2">
        <property type="entry name" value="MANNONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016049">
        <property type="entry name" value="Man_dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="329" mass="38250" checksum="0ACE560947F74D7E" modified="2017-06-07" version="1">MALNFKLAEIILESKPDRFWKILKQIGVNDAVGVLPRNYNDWRNSTEDEPWDYYPMMKYMNMLRDSGLNLIAIEDNPPMNGIMYGNSDREKEIDYISKMIENMAKLNIKIWCYNWMAGSGWSRTKSDIIGKNGEYVSGFDYNDIKNIEPPMMGKIGKDALWKNLKYFLDNIIPVAEENDVKLAMHPDDPPIENFRGIDRIMNSIESYDKLLELNRSKYNGITLCQGNFTLMTDNLPSEIRHFNDRIFFVHFRDVNGNKYNYQESLIDEGRTDMAACMRAYNDINYSGIMRVDHTPTLEGDIELVPGYSYSGRIYSIGYIKGLIDSIFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N425</accession>
    <name>A0A1V0N425_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transporter, extracellular component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142379.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N425"/>
    <dbReference type="STRING" id="74969.FAD_1029"/>
    <dbReference type="GeneID" id="31676528"/>
    <dbReference type="KEGG" id="fai:FAD_1029"/>
    <dbReference type="OrthoDB" id="56983at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050490">
        <property type="entry name" value="Bact_solute-bd_prot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43649">
        <property type="entry name" value="ARABINOSE-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43649:SF14">
        <property type="entry name" value="BLR3389 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="519" mass="56190" checksum="F42873D653DD606F" modified="2017-06-07" version="1">MQSSNPDIKPKGKVWTYVVIIIVIVAIISGGLIYYYSTFQHPAKQETISIAAPVYSSSTQDWEDFINNATQSWQAAHPNVTIKFVGPSGASSEGQYYTKLDLLTSSSSTAPSVMLEDMFYTATYQHEGILSPLNSYVNSTVFDNVFPSALGQMTINGTYYGLPAQVTDTLIYYNITLLQKAGVISSSNTTWQPTNWTQIIDAAQKVNNTLVPTDSSLIPLNIYEGSKGDEASSFTGFEGLLYGTGSGLYNFTDHKWVGYSNGLNETFGFYKTVFDEGLATSALSSTPYITAGQDLQQGKLAIAIDGSWMYGYQWAPGAQHPINNFTKYIGVAMIPTSSGQAPGFNTMVGGWGWAMYNGTPSSEKPLVASFMTALDNTSNQILINEPGQALAGGLPTAKNAVNNTNFAKLMPTAPSLDTFYTNILKYGSYRPPVAAYPKVSDALQQVMGDIVSAHYSVSHAATVYNSLLVSAVGGTSVVATTPYTPYFSINSHDTGNNQFNYMSNLYSDVSLSLLSYLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N437</accession>
    <name>A0A1V0N437_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase mutator family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0124</name>
        <name evidence="5" type="ORF">FAD_0964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141361.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N437"/>
    <dbReference type="STRING" id="74969.FAD_0124"/>
    <dbReference type="GeneID" id="31676464"/>
    <dbReference type="KEGG" id="fai:FAD_0124"/>
    <dbReference type="KEGG" id="fai:FAD_0964"/>
    <dbReference type="OrthoDB" id="56934at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033543">
        <property type="entry name" value="transpos_IS256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217:SF8">
        <property type="entry name" value="MUTATOR FAMILY TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="386" mass="45596" checksum="FA68AA48F115B922" modified="2017-06-07" version="1">MENTDINISALENVDIDRILKEAIKERIEKLMEIELNAYLEDNPGIKNGKYKRDLKTKYGEIKQLNIPRDRDSNFHTKVIEPYSRSIGIEDLIVSMYSNGISTRRIAGIMEDILGNKYSKSTISRITDLTIEEVYKFINRPLDKRYIAIFLDGLFFYLRRGNVDKEPVIFALGIKETGEYEVLGFYLTVKESHNTYKDVLEDLYNRGLKEPLLIVADGIKNMDEEVMEIYPRSEFQLCTIHYARGLKSNVREKDIDEITIDANKMFKCDNKEEAIIKFNDFKYKWESKYPKVIYNTEKNLGKLLRFYNYPSSIWRSLKSTNAIERLNGEVRRRVKTISSFPDEDSAMKVFYYKSIEYNSKHAFRKMNGYYKCNDEIKEMFQKRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N439</accession>
    <name>A0A1V0N439_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH bat-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886062.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N439"/>
    <dbReference type="GeneID" id="16024188"/>
    <dbReference type="GeneID" id="31676472"/>
    <dbReference type="KEGG" id="fai:FAD_0973"/>
    <dbReference type="OrthoDB" id="27447at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236:SF1">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH bat-type" evidence="1">
        <location>
            <begin position="141"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="200" mass="22819" checksum="948EE52EAD7C8268" modified="2017-06-07" version="1">MKGHLIEITLTAEKPSCDVLKKLAPLNLKVRIFQINPSAGSTNHLMGIENYKKIRESIKDDKITIYENQRDKTWLETHSCEICRAVALSGSIITSVKILENLKVQYKILLKNKKALETLDQSIDGINYNYVESVTKLPEELTLRQKEVLYIAFKNGYFEFQRGINLDGLASELGISKKAVQSDLKRGIDKIVKEYIFNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N468</accession>
    <name>A0A1V0N468_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cellulose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142326.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N468"/>
    <dbReference type="STRING" id="74969.FAD_1006"/>
    <dbReference type="GeneID" id="31676505"/>
    <dbReference type="KEGG" id="fai:FAD_1006"/>
    <dbReference type="OrthoDB" id="43988at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="168"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="495" mass="57363" checksum="A5104AB7E0F9FCF8" modified="2017-06-07" version="1">MGKKPYFIVFLSIIFIVLYLYFLVISLISLDKTIATKFLTVLLILINGFFIMHTLEYLYYYLIASSKYEQSVAYYFSRYFPFTTTVFIACYNEPVDVLENTIFSIKQMCKRGNDSPFILDDSTDKKTIEDIKELALKYRIGYIHRDNRRGYKAGALNDALKITDSKYFAVFDADQEPLQEFLTELIPIMEDNDDLSIIQVPQKYVNNNTPVAKGANDIQEVFYNFITEGKSLENSMFSCGSNVIYRTETIKSIGGFNEKNVTEDLATSIKLHESGYHSIYYNRPLASGEAPQTLNSYFIQQSRWSQGSIGIFFQVIKLLFRRKKLTLRQKTGYFVSTSWYFVGVVNMLMLVFPLLFIFFNIVSIITPENYIFIFAFYIIFNFFAFSSSVYSVEKSIIPVMRNMSLTFISSPIFIKSAVFALIGRKTSFKVTPKEDSSRIPLKGVWAQLLIFFITGIGFIYSVYRYLISGTLEYLLNGIFMLYFFSLSSTLFYYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N474</accession>
    <name>A0A1V0N474_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142346.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N474"/>
    <dbReference type="STRING" id="74969.FAD_1016"/>
    <dbReference type="GeneID" id="31676515"/>
    <dbReference type="KEGG" id="fai:FAD_1016"/>
    <dbReference type="OrthoDB" id="10480at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="196" mass="22068" checksum="5271FB5AE06C331F" modified="2017-06-07" version="1">MVQSETHGITLDSRFNMRNSFIRGFSMLIVPPVLLVIILLAHNFYSLEYFHVVAGSMWTGMDLILGIFFSYVMRGLDNFEKTRISMRLTPTMLYFMPAISASTITAGIYTAMALHIPFSSPYIIAALVISAILFIEGIGIFLPNELRVYNEILHGAKNTEKIVRLTMLNLKLSLIQVIFQIAIILIMAHFAVGVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N492</accession>
    <name>A0A1V0N492_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle 54 kDa protein</fullName>
            <shortName evidence="9">SRP54</shortName>
            <ecNumber evidence="9">3.6.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">srp54</name>
        <name evidence="11" type="ORF">FAD_1081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142469.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N492"/>
    <dbReference type="STRING" id="74969.FAD_1081"/>
    <dbReference type="GeneID" id="31676579"/>
    <dbReference type="KEGG" id="fai:FAD_1081"/>
    <dbReference type="OrthoDB" id="52849at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="10">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="242"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="457" mass="50741" checksum="B70145171808E120" modified="2017-06-07" version="1">MVLDNLSESLKSIMRKISGSSFIDKDTIKEVTKEIQRALLKADVNVKLVLKLTNTVQERALNEKPPAGMTAQDYIIRVIYEELLKILGTDSNFDLKPQTIMLVGLYGNGKTTTAGKLARLFMKKGLSTGLIAADVHRPGAFEQLQQISGDVNCGFYGEKGEKNALKIVRNGIKELADFKIKIIDTSGRDSLDQELIDEVHEIKEKINPDTVLFVIDATLGQQAGPQAKTLHDAVNIDGVIITKMDGTGKAGGALSAVADIQSPVYFIGTGEHMDDIQIFNPKKFLSRLLGMGDIDALMEVVKETNITEEEAEASLDKLMSGKFDLKDMYDVWEKFAKPGLLKKFFGALPLGKMPGGNKLDESQLDQADEKLRLYRVILDSMTFYELENPDVLNAKRIKRIAAGSGQGEKNVRQLLKEYNAMKKNMKSIKKNRNFKKMLKTQLKGGNFSLDDLESKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N495</accession>
    <name>A0A1V0N495_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Digeranylgeranylglycerophospholipid reductase</fullName>
            <shortName evidence="8">DGGGPL reductase</shortName>
            <ecNumber evidence="8">1.3.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2,3-bis-O-geranylgeranylglyceryl phosphate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Geranylgeranyl reductase</fullName>
            <shortName evidence="8">GGR</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. Is also probably able to reduce double bonds of geranyl groups in CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol and archaetidylserine, thus acting at various stages in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 NADH + 8 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36039"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:73125"/>
            <dbReference type="EC" id="1.3.1.101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 NADPH + 8 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36035"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:73125"/>
            <dbReference type="EC" id="1.3.1.101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + 8 AH2 = CDP-2,3-bis-O-(phytanyl)-sn-glycerol + 8 A</text>
            <dbReference type="Rhea" id="RHEA:84207"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:58838"/>
            <dbReference type="ChEBI" id="CHEBI:74004"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 A = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2</text>
            <dbReference type="Rhea" id="RHEA:64376"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:138139"/>
            <dbReference type="ChEBI" id="CHEBI:138140"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>archaetidylserine + 8 AH2 = 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + 8 A</text>
            <dbReference type="Rhea" id="RHEA:84215"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:71517"/>
            <dbReference type="ChEBI" id="CHEBI:74853"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Reduction reaction proceeds via syn addition of hydrogen for double bonds.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.101" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142466.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N495"/>
    <dbReference type="STRING" id="74969.FAD_1079"/>
    <dbReference type="GeneID" id="31676577"/>
    <dbReference type="KEGG" id="fai:FAD_1079"/>
    <dbReference type="OrthoDB" id="6062at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045550">
        <property type="term" value="F:geranylgeranyl reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046467">
        <property type="term" value="P:membrane lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01287">
        <property type="entry name" value="DGGGPL_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023590">
        <property type="entry name" value="DGGGPL_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054984">
        <property type="entry name" value="DGGPL_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050407">
        <property type="entry name" value="Geranylgeranyl_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054715">
        <property type="entry name" value="GGR_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041160">
        <property type="entry name" value="DGGPL_Thplmales"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685:SF18">
        <property type="entry name" value="DIGERANYLGERANYLGLYCEROPHOSPHOLIPID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22578">
        <property type="entry name" value="GGR_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Digeranylgeranylglycerophospholipid reductase catalytic" evidence="9">
        <location>
            <begin position="178"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid</name>
            <dbReference type="ChEBI" id="CHEBI:138140"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid</name>
            <dbReference type="ChEBI" id="CHEBI:138140"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="396" mass="43594" checksum="92D26B98D1A4F933" modified="2017-06-07" version="1">MLNYDVLVIGAGPAGSSAARYASRYGLKTLLVEKRPDIGSPVRCGEGISKAWMPEVDIKPEAHWISDEVKGARIYGPSEKKPIMLTAESAGNEVGFVVERDKFDKHIATLAATEGAEIWIKSPAMSVIKEGNRVVGAKIRHNGEEVEVRAKMVIAADGFESEFSRWAGLKSPILKKNDIISALEYRMENVDSNEDFTDFYLGSIAPAGYLWVFPKGPHEANVGIGVTITMMKDRLDVKNYLDSWIKSHPAYSKGRIIQQISGGVSVNKVKDKMSLPGLLAIGDAARLIDPITGGGIANGMISGKFAAQVSKKAIDENDFSEEMMKNYDLMVKDKFERKHLRNWFAKEKLGTLSNETLDKLVDVVADVKMTSISVEEILKGVQLKYPELVSQLEDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4A1</accession>
    <name>A0A1V0N4A1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster assembly protein SufB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Intein-containing FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sufB</name>
        <name evidence="5" type="ORF">FAD_1088</name>
        <name evidence="6" type="ORF">HLB00_00850</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-sulfur cluster assembly SufBD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000025">
        <property type="protein sequence ID" value="NOL59387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951131.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4A1"/>
    <dbReference type="STRING" id="74969.FAD_1088"/>
    <dbReference type="GeneID" id="42785076"/>
    <dbReference type="KEGG" id="fai:FAD_1088"/>
    <dbReference type="OrthoDB" id="372168at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055346">
        <property type="entry name" value="Fe-S_cluster_assembly_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508">
        <property type="entry name" value="FES CLUSTER ASSEMBLY PROTEIN SUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508:SF1">
        <property type="entry name" value="UPF0051 PROTEIN ABCI8, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="Stabilizer of iron transporter SufD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="4">
        <location>
            <begin position="374"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="835" mass="94827" checksum="4A09A00CD298BB7B" modified="2017-06-07" version="1" precursor="true">MEDYNKDEEIEKLTESLKHNKKSDFEFHDTINPVYSTGTGLNRKTVEEISDIKHEPDWMRRSRLKALDIFLSKPMPTWGPDLSGINFDELTYYSKPGETKAKNWDDVPDKIKETFNKLGIPQMEQKYLAGSVAQYDSEGVYGSLRKEWEDKGVIFTDLDTAVQEHPDLVKDYYCRAIPPSDNKFAALNGAVWSGGSFLYVPKNVTIDMPLQTYFRMNGEQSGQFEHTIVVADEGAKVHYIEGCLPEDELISQGDKFVPINELLTDDSVVSNTGNQRKITRKYVHPYSGLMYKITPLSPGNAFRATSEHPVLSIKKEDVTSRIRDGHYEISTKKLMEAIPEYRRMDELSEGDFIVYVSPVETEDDASIDDDMLKILGLYTAEGSISFNKSLNLYQMSFSFGLSEKEEKIAYELYNIIKAKGEQANIFKADKKYYTVSTYSKTLIDFCLNNAGKYADKKALSEKIMKLPPEKQKLLIDYYLKGDGNVYIKKGKSKMIRAGTASKVLALQLQEMLSRNNTFASIMIRKASDDVILGRNIKRNEQYIVEYTENIKFSRVRHKDNYYYVPIKKMEAEVYDDIVYNMEVETDDSYLVKGFAVHNCTAPKYNTSSLHTAIVEIYARKNSDVKYTSVQNWSDSVYNLPVKRAWVDENAHMDWVTGELGSKVTMIYPSSYLRGRGASTSNLQITLATKDTFKDAGGKALHLAPDTTSRIVSKSISLDNGLTAYRGLVRMNEGAKRAKSHVQCDALLINSDSKNYTYPYDEIYEPTAEFSHEATVGKIGTDELTYLRSRGLSEDEASSMIVLGFMDDIMKEIPMEFAVEMNRLVKLEMSKMGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4D9</accession>
    <name>A0A1V0N4D9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142477.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4D9"/>
    <dbReference type="STRING" id="74969.FAD_1091"/>
    <dbReference type="GeneID" id="31676590"/>
    <dbReference type="KEGG" id="fai:FAD_1091"/>
    <dbReference type="OrthoDB" id="6609at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="DNA REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Archaeal Nre N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Archaeal Nre C-terminal" evidence="3">
        <location>
            <begin position="302"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="409" mass="46197" checksum="CF97444873D3A6A8" modified="2017-06-07" version="1">MGKKLVKIPPSLCVKCRGAKMLCGLSYCPVSIVDRVKKVYTFNGNSISGSSPPSLFVGRYGYPKINIYPSTPPFSGDTAYMEDESKWLSTDLNEFLSSRLSLLRGGIKIEATKASDPDYRLQEIQISSLSSRPVDVEMTVEKSFKDNVVLDENITPMGPSSPLKSIKFGNYHIDNRIEKIYYDKDLKAGSGILKLYERGIGINGISKALSSGSLGTGKKRRIVPTRWSITATDKSISDNLVEEIKDYREIDEFEVYIRETSGNLFIAILAPGQWMFEWGESWFPGSTWNSFGDSVEVELDYEGYYGRKTYPGIGGCYYSSRLAVAEKYREIKRTGSAMLWREIYPGFNIPVGVWYVRENVRELLKGKPEKFDNIQDAIKYVGKFTKVDIKAWKAKSNNLKYLVSSLDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4E6</accession>
    <name>A0A1V0N4E6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142515.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4E6"/>
    <dbReference type="STRING" id="74969.FAD_1134"/>
    <dbReference type="GeneID" id="84217731"/>
    <dbReference type="KEGG" id="fai:FAD_1134"/>
    <dbReference type="OrthoDB" id="132045at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="312"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="471" mass="55473" checksum="DEA8CC8C8DBD5635" modified="2017-06-07" version="1">MFIGRKNEINYLTSQYRNNESSLILIYGRRRVGKTALIEEFIKSKKYIYLLATQQDINIIIRNFSMEMAEFFHDDITYRNPLTNWDDLFKYLIKNLQNVDEKIIFALDEFTYLVAKDKSILSILQKYYDLYFKDMKIFIIITGSLMGIINDKILSYESPLYGRRTGNILLNEMNLWEIKDFFPYYSVQDLIKIYSITGGLPYYLSALKNKKFNDIISTVINKNSIFYNDAFFILKEELKEPSKYFSILNIISTGHNRIGEIASLLNTNSGEITQYLDNLIKLGIISKRKPFFSNESNKQSIYKINNNYFNFFFRYIFPYQNLIEIDNYNVLLNIIKNDFDFYTSKIFEDISRNILFKFGKNLTGDNITGIGTWWGKNKLENNGKNEEEIDIIALTEDKNIIVGEVKWRNKPLKIEVLYSLQNKSVFIKPYKYILFSKSGFDENLTKLSEIDKNIILVDLNKIGELFNSIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4F9</accession>
    <name>A0A1V0N4F9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1137</name>
        <name evidence="7" type="ORF">HLB00_04820</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000164">
        <property type="protein sequence ID" value="NOL60158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142521.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4F9"/>
    <dbReference type="STRING" id="74969.FAD_1137"/>
    <dbReference type="GeneID" id="31676635"/>
    <dbReference type="KEGG" id="fai:FAD_1137"/>
    <dbReference type="OrthoDB" id="57111at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09299">
        <property type="entry name" value="TDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
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        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
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        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="102"/>
        </location>
    </feature>
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            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="345" mass="39946" checksum="8408BB3928C38BCE" modified="2017-06-07" version="1">MAYKGLDSTWFPVVLGTLSVSLAFFIIYLVFHNVLIFNIGKIIYFIVLIFFAFVFASWIYRYIKNKKLIKEDYNDMTKLSFLAFLGIFYYAFAFFYVAYVGVNAFVAYLFYYLLFLFYILVLVINIILNYNLYTNKYSFDRITYAILVPNVVMSANIILTSIMLTPPMSGYYNTTILRTVYFMVMVAFGISFFQFLFVGISAYISHISNKPNYLQTVPAAMIPVGASSMLIINIMFMPQFNYIGIFNVPLNLAIDISVILWGFDLFLFLVSGAIAITHIKKRQSMTVWAYVFPVGVSTFADYMIYDYTKLEIFVYSIIAFTAALIILYVYSWINTYFITGRPVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4G5</accession>
    <name>A0A1V0N4G5_9ARCH</name>
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        <submittedName>
            <fullName evidence="8">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trxA</name>
        <name evidence="8" type="ORF">FAD_1125</name>
        <name evidence="9" type="ORF">HLB00_00335</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000011">
        <property type="protein sequence ID" value="NOL59286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142497.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4G5"/>
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    <dbReference type="GeneID" id="84217723"/>
    <dbReference type="KEGG" id="fai:FAD_1125"/>
    <dbReference type="OrthoDB" id="35385at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-disulfide reductase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GEO12009P1"/>
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    </dbReference>
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        <property type="entry name" value="GEO12009P1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="43"/>
        </location>
    </feature>
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        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="118" mass="12908" checksum="5236711CE5ADDB2C" modified="2017-06-07" version="1">MENNNVFGKSSGTSGPVELNDGNFQSFVSSSKLSVIDMWAAWCAPCRYLSPVVDELSKEYANVANFGKVNVDENPVTSRNYRIESIPTILFFKNGKAVDMSIGVVPKEVLAQKIKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4H7</accession>
    <name>A0A1V0N4H7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142505.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4H7"/>
    <dbReference type="STRING" id="74969.FAD_1129"/>
    <dbReference type="GeneID" id="31676626"/>
    <dbReference type="KEGG" id="fai:FAD_1129"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
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            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="451" mass="50357" checksum="D56645421785009B" modified="2017-06-07" version="1">MESNTVADFVYKHNNIKGAYMVFIASASVFLDVWDLTSFGFVLDFFKADLHPVGFMLGISVAAANIGAIAGAIFGGYLTDKFGRKRLLMYNMVVFIIFAFLIAISTNIFEFTLFRLIMGFSIGSDVATGFSYIYEYISRKQRNRYYSLWAYSFSVVALIAIASVFLLYHIIHNDSVWRYIFVIGGIFAAIILLLRSRMTETPIWLYGNGKYKETHDVIKHVYGEDININQSGQKTHVTLKNLISLFHNRLNRELVFAFSLNGIVGFIGWGFAFYITYMLETLKLFTFYQILGADAVIYSFGFAGAIISPVLAKHLGIYRASVIPAIIAAIAIFALFITFAGILPVYLVIPFSIIIIFMNYSGPMAYNAVLNGFIPTSLRGIGNGWNYMFNKITEAVSGLTGGAILVLVGLKFNTIILFIIVAVFTVIAVYTGKSKYFKKGYASDLQTSPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4L5</accession>
    <name>A0A1V0N4L5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase subunit G</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">CoxG protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1205</name>
        <name evidence="2" type="ORF">HLB00_06240</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000215">
        <property type="protein sequence ID" value="NOL60431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142593.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4L5"/>
    <dbReference type="STRING" id="74969.FAD_1205"/>
    <dbReference type="GeneID" id="84217800"/>
    <dbReference type="KEGG" id="fai:FAD_1205"/>
    <dbReference type="OrthoDB" id="57259at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05018">
        <property type="entry name" value="CoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="BLL0334 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588:SF1">
        <property type="entry name" value="BLL0334 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="150" mass="16449" checksum="6B91484A314BEAD7" modified="2017-06-07" version="1">MLTFEDSFDVKTTPEKAYGYVVDQEALIKLIPDLLNYEKVDENEMKLTAKAGVSFIKGKFDLVLDITDKKASEHITLKGKGNGSGASVDFTVNFDFLPDDQGTKVNWKADMNIVGTAASMGARMLKSAAQKYIVKLVGNYKKALEEDAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4M8</accession>
    <name>A0A1V0N4M8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1220</name>
        <name evidence="2" type="ORF">HLB00_08760</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000331">
        <property type="protein sequence ID" value="NOL60910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886324.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4M8"/>
    <dbReference type="GeneID" id="58788959"/>
    <dbReference type="KEGG" id="fai:FAD_1220"/>
    <dbReference type="OrthoDB" id="55708at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="53" mass="6055" checksum="E3244A5C04F2E699" modified="2017-06-07" version="1">MGESLADIEISKDGEIYYVRMTLPSGEVVSMENENFEEILEEIANDLQDRYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4P5</accession>
    <name>A0A1V0N4P5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CBS domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_1208</name>
        <name evidence="14" type="ORF">HLB00_06255</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Berkeley</strain>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000215">
        <property type="protein sequence ID" value="NOL60434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142609.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4P5"/>
    <dbReference type="STRING" id="74969.FAD_1208"/>
    <dbReference type="GeneID" id="84217803"/>
    <dbReference type="KEGG" id="fai:FAD_1208"/>
    <dbReference type="OrthoDB" id="89900at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04594">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00400">
        <property type="entry name" value="Voltage_gated_ClC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000018">
        <property type="entry name" value="Chloride transporter, ClC family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050368">
        <property type="entry name" value="ClC-type_chloride_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0868">Chloride</keyword>
    <keyword evidence="7" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="524"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD85081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="NOL60434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="587" mass="63778" checksum="E369281B55442225" modified="2017-06-07" version="1">MNLKLSTLPYFQRWFIVGAIIGVVAGFGALAFYFAIRLFELIFFTHIVGMPIPHPLGEGGSLVYHFYALRYYLIPVVVAAGGLITGFIIYTFDPSSEGHGTDAAIRSFHYNHGKIKRRTPVVKTIASAITIGSGGSAGREGPTALIAAGIGSFLADILGLSPKDRRIAVAVGIGAGIGTIFKAPIGGAVLGAEILYRRDFESEVIFPSLVASSIGYSIFASVVGFAPIFGDYLNTFNVLRLPFYAVLGLVAGLFSILYIRTFYGVRNLFKKFKIPNHFKPMIGGAIVGVIALLFPEILGTGYGWVELLEYGKFNELVTFGLPILLILVLLPFVKIIATSFTVSSGGSGGVFAPGIFIGASLGALFGVLFHMVSPGIVPAVAPFVIIGMLSFFGAAGKAPLAVILMVVEMTGSLQLLPGAMLAVSIAYIASGTKYSIYESQVEQRRDSPANMGEYHTPMLLEMKVSSLNIINDVYADLYYTIYRADNIMKENELLSLPVVYHEKLMGAVYLYDIVNRSYGYVKDYYKAGISYVKLENSAENAWELMMKNRTKWCAVVDNGKFMGIITLDSILNKYEDDIKLINQEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Q2</accession>
    <name>A0A1V0N4Q2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="9">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">ribA</name>
        <name evidence="11" type="ORF">FAD_1219</name>
        <name evidence="12" type="ORF">HLB00_08765</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000331">
        <property type="protein sequence ID" value="NOL60911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142627.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Q2"/>
    <dbReference type="STRING" id="74969.FAD_1219"/>
    <dbReference type="GeneID" id="84217813"/>
    <dbReference type="KEGG" id="fai:FAD_1219"/>
    <dbReference type="OrthoDB" id="25735at2157"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10990:FF:000002">
        <property type="entry name" value="GTP cyclohydrolase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="47"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL60911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="192" mass="22112" checksum="329D8F43DC4C42BA" modified="2017-06-07" version="1">MIEFYAKAKLPTRFGVFNIYVFKNEDNKDHAVLVHGDIEGEENVPVRIHSECLTGDVFGSMRCDCRDQLITSLKYIGSRERGMLIYLRQEGRGIGLLNKIRAYNLEDNGKDTVEANIEQGLPADNRHYNFAVDVIKYLNIKSIELMTNNPEKIKNLEENGIKISKRIPVIIEPNSFDKFYLETKKDKMGHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4R5</accession>
    <name>A0A1V0N4R5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886329.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4R5"/>
    <dbReference type="STRING" id="74969.FAD_1226"/>
    <dbReference type="GeneID" id="16024454"/>
    <dbReference type="GeneID" id="31676723"/>
    <dbReference type="KEGG" id="fai:FAD_1226"/>
    <dbReference type="OrthoDB" id="11098at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="251" mass="28413" checksum="302C7BC321A0B0DC" modified="2017-06-07" version="1">MQYNASVVIPALNEKENLNRLIPALADDNISSIYIIDDQSTDGTADLVKKYPDVHFLFRGGRLGLISAEIDGMRLSGTEYVVVMDADLSHRPEDVPGLIDQAIRTSSDLVIGSRYTDKGITNDEFIRKIISRIANMLFRISFDINLNDCTSGFRVYSRKACDYLGKQVDIENGYVGQVDIVSRLAHNGFKITEYPVVFVKRTQGKSKLKMREIVNFFLFVIYNKKIFRAILGMAALVILMIVFSYLFILFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4X0</accession>
    <name>A0A1V0N4X0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142770.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4X0"/>
    <dbReference type="STRING" id="74969.FAD_1293"/>
    <dbReference type="GeneID" id="84217889"/>
    <dbReference type="KEGG" id="fai:FAD_1293"/>
    <dbReference type="OrthoDB" id="56751at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006108">
        <property type="entry name" value="PRK08259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="255" mass="27625" checksum="5BD95A7446CEDEC9" modified="2017-06-07" version="1">MGEINIKKHGHITIISINRYNRRNAVDYKTSKMLENAFLDFNIDTEQHIAIITGENGIFSAGADLNDAKAMSQEVLGENGPMGFTRMKIVKPVIAAISGYCVAGGLEMALTADIRIADADSMIGFLERRFGVPLIDGGTQRLPLIIGMGRALDMILTGKLVSADEAKSIGLVNYVTEHGKSLDKAMEIAKLMDSYPAVTMLNDRLALLEGLSRPLCEGLRIEAEYGKKTIDSGIVEDGAQKFIAGNGRHGKIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4X6</accession>
    <name>A0A1V0N4X6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142800.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4X6"/>
    <dbReference type="STRING" id="74969.FAD_1324"/>
    <dbReference type="REBASE" id="195971">
        <property type="entry name" value="FacYORF1325P"/>
    </dbReference>
    <dbReference type="GeneID" id="31676816"/>
    <dbReference type="KEGG" id="fai:FAD_1324"/>
    <dbReference type="OrthoDB" id="142771at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120545">
        <property type="term" value="F:nucleic acid conformation isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="119"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1002" mass="117027" checksum="49D49F44F83A858E" modified="2017-06-07" version="1">MEERIIPVYQRLIHNVDSSSLPDSWDFTFDKFSESKKLYDYQKDALKSGLKFLHHYYSDILNYPESEYNSSILEGKKSLFNEINTERIVKHTDILDISVKNTSIFKIASQFYNVEGKRIPFFNFTNRMGFWMATGSGKSLVIVKLIEILNELKKRGSIPDEDILFLTYRDDLIDQIKKQIDEFNSFSPVKIKYWDLKDYDKVKHDLLFNRDDINIFIYRSDLISDTSAEKLLSFEDIENNGKWYIILDEAHKGTNGDSKRQIFYSILSRNGFLFNFSATFTDRWDIITTVFNLNLDRFTEKGYGKNIYVSQQDLSALEGYNKDSDSIERRDEKKKIVLKTLITLAMVKKAYKQLSTVSANIYHNPLLLLYGHTTEVENADIEIFFETLGDIALNRIDSRIFEECKNSILDEFINNPTYVFGKDTDSNKLRFNYNDFSNLTFDDVLKLVYNSDGAGKIEVVRTKANKAELAFKLKTSDKYFASIKIGDITKWLNDKLVGYEVSENPTEDSFFNNIDNNSSPINILMGSRSYYEGWDLNRPNVMVFVNIGKGDAKKYVLQSIGRGVRIEPLKNKRQRIAELSRNGDLEAKKIFSILQEKNYEGLISIIETLFIFGTDENNIKAIMDGIKFELEKNGEILDVKKTKFDFNPKLLLPVYLEKKEVELKELPKFSGNLNLLEDYVNWMEDDRVIYANYSDVATPATIGRLHNYLNADNIQNTNSSNAYNQLHNLIGHLNTSIKYMDKFKDLEDEIIHFKEISAEGISKEKKNELNKKIEDVRNLKNSDFVEKNLLQKFKSGEMSERDLKEYGDLMKKMGKIEKPTLFEFDESKIELINIAQHYYLPIILSISDKADVLSHVIKVKSEKEFIHNLDEFIAKEGLKSYKLDWWVFSKIDESIDNVNIPYFDKGKNRMRDYSPDFIFWLKRGSEYRIVFVDPKSTKYTDYEQKADYFSKLFEENGFPKEFQYGGFSIKVHLFMVTDNINSVGENYKKYWIDNIEKIFSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N510</accession>
    <name>A0A1V0N510_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940561.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N510"/>
    <dbReference type="STRING" id="74969.FAD_1350"/>
    <dbReference type="GeneID" id="84217962"/>
    <dbReference type="KEGG" id="fai:FAD_1350"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054929">
        <property type="entry name" value="dPGM_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038349">
        <property type="entry name" value="dPGM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="199" mass="22281" checksum="9154D082ABA19619" modified="2017-06-07" version="1">MRGYIFIRHGESNINVEKVLSDDVDHNTLTDTGEKQAERTGEQLTGLKFDGIISSPIKRAYDTANIISNYVGLDVKIDDRLREVYLGNANGHNINEFLDTLYPNSHITGKVRDSLGMETWEHLQERVKACMDDYKGKYIFVSHSDPIRAIASYYMGLSEGESFGMAIKNASMTVIARSPLKLLSLGAINLDDKIKSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N528</accession>
    <name>A0A1V0N528_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">marC2</name>
        <name evidence="8" type="ORF">FAD_1371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886471.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N528"/>
    <dbReference type="STRING" id="74969.FAD_1371"/>
    <dbReference type="GeneID" id="16024596"/>
    <dbReference type="KEGG" id="fai:FAD_1371"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00427">
        <property type="entry name" value="NAAT family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="UPF0056 MEMBRANE PROTEIN YHCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508:SF1">
        <property type="entry name" value="UPF0056 MEMBRANE PROTEIN YHCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="200" mass="21632" checksum="11BF81A9665BCF58" modified="2017-06-07" version="1">MTFSTDFLKVFMPLFVVIDPFGSLAIFVSMTGSFNRDTRRTISRDAVFYAGIIIILFALAGGLIIEFFGISIEALEIAGGIILLLMGIEMVRQGAKPDTSVDSSKNMGIVPFATPLLAGPGAISLVIILMKGDLFTKILTIVSVLLVLVIVYFFFIYSSKILSLLGDKVMTAITRIFGLLVAGFAIQYFLDALVALSVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N583</accession>
    <name>A0A1V0N583_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142899.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N583"/>
    <dbReference type="STRING" id="74969.FAD_1434"/>
    <dbReference type="GeneID" id="31676926"/>
    <dbReference type="KEGG" id="fai:FAD_1434"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18144" checksum="4442466273DE6AF1" modified="2017-06-07" version="1">MVKKKVIVGIVLIVIGISLVIGGVATITGEPSDHTVKEYSSNVYTSTQFNFSTNRVLLMVTSDNSSAGLVNCSNIQEHASSFNSSNIHNYTVAPAKYVDGEPYYANLNGTYKYVVVTDKAPTMDYNFVTSSELARVTDASYVAAAGALLTGSGIIIAMVTILFGKINARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5A6</accession>
    <name>A0A1V0N5A6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mandelate racemase subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142891.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5A6"/>
    <dbReference type="STRING" id="74969.FAD_1417"/>
    <dbReference type="GeneID" id="31676910"/>
    <dbReference type="KEGG" id="fai:FAD_1417"/>
    <dbReference type="OrthoDB" id="42605at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03316">
        <property type="entry name" value="MR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="2">
        <location>
            <begin position="164"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="409" mass="45229" checksum="9BD53389F86C9285" modified="2017-06-07" version="1">MKIKKVTTAVVEANFDWTFVKVETDSGLTGIGEAFCSPGLTKVIKEFGSLLIGKDPLQIEPLVRDMRYAGSPSGSSGLIFHAITGIETALWDIIGKHLDAPLWQLFGGSYREKVQIYADCHAGDALESLDPLLQPRKPAWDRSKSQWSPDIGTYSPEILDDYTPEAYAEKAKKMVAEGFTALKFDLDVPNPYSRDKYNSSLSNEEINYLASLMKGVRDAVGSGIDIAADCHWKFSPDASIRLANALAPYKLLWLEDPIPPENIDAMRYVTDRSPVPILSGENLYGRYGFREIIEKQAVSIVAPDFQKTGGLSEARRIAEMADSYYMPVAPHNISSPIGTMASVHLSAAIPNFLVLEWHASDVPFWNDIVNESHIIQNGFVKIPDKPGIGLTLNEDTIRKYAKPGETVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5A9</accession>
    <name>A0A1V0N5A9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS605 OrfB family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142894.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5A9"/>
    <dbReference type="STRING" id="74969.FAD_1421"/>
    <dbReference type="GeneID" id="31676913"/>
    <dbReference type="KEGG" id="fai:FAD_1421"/>
    <dbReference type="OrthoDB" id="56643at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF11">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE RV2885C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas12f1-like TNB" evidence="2">
        <location>
            <begin position="243"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="349" mass="39760" checksum="1F39B784198144C2" modified="2017-06-07" version="1">MILTYKIKHGRDFSEELNKARLIAEFAIKTKSITSRDVKQFGLKSAISNQILRKYSRNSKAKDVHSIKLTVPHQGIKCNQIDRTINITPLKLTLNYYFRNDFDKISQIELDNKFAYVSINIPDNDLIEPNGYLGVDRNTTGHIAVAGNPETGKIIKLGKEAGHVHKKYKNMRKNLQKKGKYRKAKRIKNRESRIVKDINHKVARKIVQEAKDNGMGIKLEYLNGIRNAKSGRSFRYSLNSWSFYELKNMIEYKARLLGIPVAYVDPYNTSKECSRCGQIGNRSGKSFKCTNCGHVDHADANASFNIALRPVFEEGIDQLYVDRDAYKGNTDIPKEATLGTMATLEPHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5B7</accession>
    <name>A0A1V0N5B7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1443</name>
        <name evidence="4" type="ORF">HLB00_01325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000038">
        <property type="protein sequence ID" value="NOL59478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886547.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5B7"/>
    <dbReference type="STRING" id="74969.FAD_1443"/>
    <dbReference type="GeneID" id="16024672"/>
    <dbReference type="KEGG" id="fai:FAD_1443"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="145" mass="15917" checksum="195827C1E9F44BED" modified="2017-06-07" version="1">MKVLVSYDGSEGAREALKYALELKCTVDEYYIVYVIPTIVGISASFDSYIPQSVYEGQDKTADQILEKAKKVLDKEEAKYELIKISSNGEEIPKIILKTAEEKGINLIVTGTRKLHGFSKLILGSVSSGIIAHSNIPVTVVPPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5C1</accession>
    <name>A0A1V0N5C1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886586.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5C1"/>
    <dbReference type="STRING" id="74969.FAD_1480"/>
    <dbReference type="GeneID" id="16024711"/>
    <dbReference type="KEGG" id="fai:FAD_1480"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="127" mass="15758" checksum="19E8D9AD806E52D7" modified="2017-06-07" version="1">MVKNYSGHIIFDENFQWKDLEKYFPDMWEIVESESKLNQEEKQFDDILLELNMEEIRKNKKPFGYRRENTRFKMIFPQDRKELTIYRNIISEEIEELTEKVAHEIRNKKIKYTLKYDQMLSIKLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5C5</accession>
    <name>A0A1V0N5C5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Adenylosuccinate lyase</fullName>
            <ecNumber evidence="5 12">4.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FAD_1438</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="5 12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142903.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5C5"/>
    <dbReference type="STRING" id="74969.FAD_1438"/>
    <dbReference type="GeneID" id="31676930"/>
    <dbReference type="KEGG" id="fai:FAD_1438"/>
    <dbReference type="OrthoDB" id="7033at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01360">
        <property type="entry name" value="Adenylsuccinate_lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="360"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="NCBIfam" id="TIGR00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD85296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="455" mass="51382" checksum="AB66ABE0B38F8B2C" modified="2017-06-07" version="1">MIVSPLDYRYGRDNVKNIFSEETRLNIMLNVEAAIAQAESYYGIIPEEAYADIRKVVDNNEVKIGRVKEIEAIINHDVMSIVEGLTEKCTTGKNYVHFGVTSNDINDSASAVQMKRAISIIISDLEDLGKALVSRIKENEETIMVGRTHGQHASPITLGLKFAVYLSEIGRHLERIQEARKRIIAGKILGPVGTGAALGKNALKIQEKTCEILGITHETGSTQIVGRDRYIEYLSIINNISVSMEKFATEIRNLQRPEIYELSEYFDSDKQVGSSSMPSKRNPIVSENIVSLARLTRSFIIPEYEAGVQWHERDLTNSALERFTIPYVSILADDIITKMTGVFSHLFINREEMKKRAYGDEFIMSESVTTTLTENGMPRQDAHEFVREASMHAYKQKKTLKETLVDMGILNHISEKILDRAMEPENFLGVSKEICEDAIKNFDNLQKYLAGEIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5F0</accession>
    <name>A0A1V0N5F0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_1466</name>
        <name evidence="13" type="ORF">HLB00_04500</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000152">
        <property type="protein sequence ID" value="NOL60095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886571.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5F0"/>
    <dbReference type="STRING" id="74969.FAD_1466"/>
    <dbReference type="GeneID" id="16024696"/>
    <dbReference type="KEGG" id="fai:FAD_1466"/>
    <dbReference type="OrthoDB" id="56011at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17926">
        <property type="entry name" value="DEXHc_RE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040699">
        <property type="entry name" value="XPB_DRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18458">
        <property type="entry name" value="XPB_DRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="72"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="304"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL60095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="443" mass="50850" checksum="06079593E244087E" modified="2017-06-07" version="1">MEIYFKAGSIISDENYSGIFSYDERIKKYRALAYRYVDIIKKPGIIDNVFKDKKLEISSEINLRPYQKKSLEMWQRNNYSGTIVLPTAAGKTILGIYAITMLKVPTIILAPTIELIIQWREKLRDLLNVEVGQIGGGEKEIRDISVSTYDSAYLMAESLGNRFKFIIADEVHHMASESYLQIAKYYASPYRLGLTATYERDDKLHEVLEKYMGGKVFELGYEELNDFISNYKIVRIPIDLTDEDEIEYEKNHTIFLSYLRKRDIKINGNMNFEDLIRSSWSAEGKEALMAWRKSREIAFNAERKVEYLKYLLSKHAGEKIIIFSEDTSTAYLISREFLVPALTYMTSGKERKKYLEMFKSGEITVLATSRILDEGVDVPDASIAIIMSGSGSTRQFRQRLGRILRPSEGKASYLYELVSSGTTEYGTSRRRRKGVPVGLNDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5H5</accession>
    <name>A0A1V0N5H5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fhs</name>
        <name evidence="7" type="ORF">FAD_1543</name>
        <name evidence="8" type="ORF">HLB00_03560</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000114">
        <property type="protein sequence ID" value="NOL59910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886683.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5H5"/>
    <dbReference type="STRING" id="74969.FAD_1543"/>
    <dbReference type="GeneID" id="16024812"/>
    <dbReference type="GeneID" id="31677034"/>
    <dbReference type="KEGG" id="fai:FAD_1543"/>
    <dbReference type="OrthoDB" id="53075at2157"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1510.10:FF:000001">
        <property type="entry name" value="Formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1510.10">
        <property type="entry name" value="Domain 2, N(10)-formyltetrahydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010030">
        <property type="entry name" value="PRK13505.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="537" mass="57114" checksum="E43AB52C161CECCD" modified="2017-06-07" version="1">MLQDIQEILKSLGINDYELYGKYAAKIGISNCNGGKRHGKLILMTAMTPTPAGEGKTTTAIGLAQALKKLGKNAGIAIREPSLGPCFGVKGGATGGGKSTVEPSDKINLIFTGDFPAISAAHNLLSAMINNHIYFGNELGIDPKKITFPRTVDMDDRSLRSIIVGNGGKSNGVLANDSFVITAASEIMAIMALSKSFQDLKNRLGNIIIGYTPNNRPVFARDIKANGAMAALLADALKPNIAQSVENVPAIIHTGPFGNIAHGTSSILGDYAALNMFEYTVTEAGFGSDLGFEKFMDIVTREAELPVNAVVIVATIRAIKHHGNAENIDSENLPAIEKGIGNLLAHVKNVRNFGIEPVVALNIHPLDTEQEIKKVCGLLDSAGIKYAESRVYSSGGEGGVDLARKVLESIGENKINYAYSMDDPIKAKIEKIAKTVYGADGVEYSKEALMDIKHAERNGFSSFYVCMAKTQSSLSDNPSLINVPVNFKVKVNSVSINAGSKFIIPILGSIMTMPGLPRHPAAENIDIDDKGVITGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5L7</accession>
    <name>A0A1V0N5L7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1576</name>
        <name evidence="4" type="ORF">HLB00_08275</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000308">
        <property type="protein sequence ID" value="NOL60821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142963.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5L7"/>
    <dbReference type="STRING" id="74969.FAD_1576"/>
    <dbReference type="GeneID" id="31677067"/>
    <dbReference type="KEGG" id="fai:FAD_1576"/>
    <dbReference type="OrthoDB" id="56831at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="252" mass="26975" checksum="A04197862231AAAD" modified="2017-06-07" version="1">MRLSNKNAIITGGAGSIGSVVAKRYLEEGANVLIVDRDQKAIDSTLNELDGQGDNLTGLKIDVTSEESIRDTVQKATKIFKNGKIDILANIAGIGPFAKFPELKVEDWDKTLSVNLRGTFITSKYVVENMIENGGGVIVNMSSTNGLLAEEGLAAYNASKAGVILLSKTMALELAKYKIRVNSVCPGFIRTKLQDSAGLPKDMIDNYISKIPLGRLGTPLDVANVFVYLASDESAFITGTEIVVDGGQICQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5P5</accession>
    <name>A0A1V0N5P5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription regulator (HTH)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1624</name>
        <name evidence="2" type="ORF">HLB00_02470</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000075">
        <property type="protein sequence ID" value="NOL59698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886756.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5P5"/>
    <dbReference type="STRING" id="74969.FAD_1624"/>
    <dbReference type="GeneID" id="16024891"/>
    <dbReference type="KEGG" id="fai:FAD_1624"/>
    <dbReference type="OrthoDB" id="55826at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="71" mass="7665" checksum="B7EA141FE10D77A2" modified="2017-06-07" version="1">MVGLSGNAEKIYSSLKAMGAVSEEKMKTADDIMKKVALGKALVNSGLKELMDGKMVKRVARQKSAGYFILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5U3</accession>
    <name>A0A1V0N5U3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5U3"/>
    <dbReference type="STRING" id="74969.FAD_1675"/>
    <dbReference type="KEGG" id="fai:FAD_1675"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="104" mass="11804" checksum="940B2B203C7B84DD" modified="2017-06-07" version="1">MGAEFDSSFKRLLWWIFISTRGGEMRIKVMKSLMESPKNAYGLSCSLGVNYRTIEHHMKVLLSNNFVVVQGQGYGKVYFPSPTLINNIKIFQETLAAAGIKWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5U8</accession>
    <name>A0A1V0N5U8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_1615</name>
        <name evidence="14" type="ORF">HLB00_01660</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Berkeley</strain>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000043">
        <property type="protein sequence ID" value="NOL59542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886747.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5U8"/>
    <dbReference type="STRING" id="74969.FAD_1615"/>
    <dbReference type="GeneID" id="16024881"/>
    <dbReference type="KEGG" id="fai:FAD_1615"/>
    <dbReference type="OrthoDB" id="145578at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000007">
        <property type="entry name" value="Thioredoxin-dependent thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF4">
        <property type="entry name" value="AHPC_TSA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="11">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD85459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="NOL59542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="149" mass="17028" checksum="21A22C80A99DFD33" modified="2017-06-07" version="1">METLKIGEQAPDFETIDQDGKNVKLSDFKDSVVVLYFYPKDNTPGCTMEAKNFRDNIDMFTEKGVKVFGVSVDSSESHKKFQEKYNLNFTLLSDKQKDIVKKYGVLGLATAKRVTYIIKDGKIVYVYPKVSPGEHAKEVYEKLQELKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5V3</accession>
    <name>A0A1V0N5V3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142998.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5V3"/>
    <dbReference type="STRING" id="74969.FAD_1653"/>
    <dbReference type="GeneID" id="84218246"/>
    <dbReference type="KEGG" id="fai:FAD_1653"/>
    <dbReference type="OrthoDB" id="57159at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="105" mass="12408" checksum="7A93B19932F0D6DE" modified="2017-06-07" version="1">MANYKYRKYGTRVNKNYRENNGEKASKKLDMRREDEFNYMLGTMLKDLPDSVRGAVRGSIYAITSKKGIKDAKEYIIKKKEDGTIDEKMEKNLIDLIYSYSKYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5W9</accession>
    <name>A0A1V0N5W9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1635</name>
        <name evidence="8" type="ORF">HLB00_02415</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000074">
        <property type="protein sequence ID" value="NOL59687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886767.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5W9"/>
    <dbReference type="STRING" id="74969.FAD_1635"/>
    <dbReference type="GeneID" id="16024902"/>
    <dbReference type="KEGG" id="fai:FAD_1635"/>
    <dbReference type="OrthoDB" id="7284at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="172" mass="19236" checksum="D0134D5FB00CCCDE" modified="2017-06-07" version="1">MEERLKRPSWDEYFMRMAYLAASRSNCTRRKVGAVIVRDNNVLATGYNGPPSHTVNCDIVGCIRDELNVPSGERHELCRGLHAEQNAIIQAAVNGSSIKGSKIYVTTHPCVVCSKMIMNSSIEEIIFAEGYPDDLAELMLLESNITIRKFNLPDPEVESIIGIYYTHKTGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5X4</accession>
    <name>A0A1V0N5X4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143016.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5X4"/>
    <dbReference type="GeneID" id="84218272"/>
    <dbReference type="KEGG" id="fai:FAD_1674"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="63" mass="7400" checksum="AF5440841A1D464F" modified="2017-06-07" version="1">MERLAILDYIIGAVAIIMVIYTAVSNIYFSFRFFTYYAALPTVIILVILYLLHRHIYKLRNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N649</accession>
    <name>A0A1V0N649_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-isopropylmalate dehydratase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143091.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N649"/>
    <dbReference type="STRING" id="74969.FAD_1789"/>
    <dbReference type="GeneID" id="31677279"/>
    <dbReference type="KEGG" id="fai:FAD_1789"/>
    <dbReference type="OrthoDB" id="255at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043436">
        <property type="term" value="P:oxoacid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001614">
        <property type="entry name" value="PRK00402.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="6">
        <location>
            <begin position="74"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="416" mass="45302" checksum="239DEFEBA5B3763F" modified="2017-06-07" version="1">MNIVEKILFNHSAEPVNNISPGDIVTVNVDRTIIVDMAALHPEFIENPPVKPFNPEKISLVFDHYVPAPGIEIANRVNRLRKLVNRWGIRDFYDVGRGGISHVLGGEKGWFRPGSLIANTDSHTIATGAFNTLGRGLGTPEIMNIIATGKTWFLLGETLKVNLENSMRPGTSAKDVFFYMSSVIGDVPNKNIEFSGNGIYSLNIDQRSSISTMCAEVSAEFAVFPEDKVLRQYMVERGYGNYRPAAPDRDAEYANEINIDMEKIEPMVALPDRIINNVKPISEIGKVEIDVAVVGSCANGRLSDLRDVAEAVKNKKINDNVRFIVTPASKEIYEEALRLGYIDTIIKSNAMVTNPTCGACLGGHMGVVGNGDTVLSSTTRNFKGRMGAGGARIYLASARSVAISAINGYISGGFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N675</accession>
    <name>A0A1V0N675_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143095.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N675"/>
    <dbReference type="STRING" id="74969.FAD_1794"/>
    <dbReference type="GeneID" id="31677284"/>
    <dbReference type="KEGG" id="fai:FAD_1794"/>
    <dbReference type="OrthoDB" id="9937at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF2">
        <property type="entry name" value="BLL5683 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="229" mass="26323" checksum="851AFE0C31326CB6" modified="2017-06-07" version="1">MKLLVLSDIHGNFDALQSVYDKEKYDKMIFLGDAVDYGPEPDRVLDFLKANSDINILGNHDNAVLTGSSCNCSFDMLELSDYTREHISMKLLGKNDMALLKTFKLNTDTEIDGKKFYMAHASPYNNLDGYLFANEAEKVFRNKPFFDSHDYILIGHTHFMMVYRNKIINPGSVGQPRDFTGKPSYAVIDTETMAISFKRVTYDAESMLEKLKTLIPDKDIYEKLRKYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N680</accession>
    <name>A0A1V0N680_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143094.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N680"/>
    <dbReference type="GeneID" id="31677283"/>
    <dbReference type="KEGG" id="fai:FAD_1793"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="502" mass="56075" checksum="0A9E58FFA0C68BEF" modified="2017-06-07" version="1">MNRKRVIIGVTMALIFVFTAFSPAISNNTNIASSVPEIASISNSINKIPVFNIKPAGKAYDFNNNGVTFSGNDPYIKLNNQYYPSQWIISNNTNSQKLNIIDNKKIVSKFQNSAVEILKDKSIKVAYIYLFYNNSVHADITIKNLKNTTGNYTVQFNLMLPSSNIMENNHNINNEFSNVYANNKYINLINIKNPYNSLSFNNVMINPSASFPLHTTIMKDNSYAVLNMAYNVILTKNETYTIDPVIENYRGSNVVTYGTITTGISTGACLFNSNGKEIGVITETAQTGSTLYADSTKAYVEIDTTFSPTSSSYDVNCIEQKIVDSNGGNSNFVERNYYSVLQYHEEQSCPKIQSAINAAFFFLNSILAIEGISIPNPSSLFSSSSDVSAGDVTNGYQITANAGTTTSAKAGVYWNPITLSYWTYLYGFIPEYHTYDVHEFGDCLEFHFQQPYGTHTNPYADPMTYTSTFTITNSDMKPVEFENQQYKAQISENFDLEQYSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N687</accession>
    <name>A0A1V0N687_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Potassium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FAD_1804</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940573.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N687"/>
    <dbReference type="STRING" id="74969.FAD_1804"/>
    <dbReference type="GeneID" id="31677294"/>
    <dbReference type="KEGG" id="fai:FAD_1804"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="13">
        <location>
            <begin position="121"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD85643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="329" mass="37417" checksum="63D370B63A7E5887" modified="2017-06-07" version="1">MNPFFLFFKKFRKYSRNHVIKASILTIAVIVYSVFSEFFIEDSIVSSGIHSLFSSLWWTMQTITTVGYGDTPVYGLAGRANGMLIMVIGIGSLGYLMAGLTSMLIDIRLSSKLGERMAAEKKHIVLCNYNESTKKVLDKIKYDGIDIVILNENEVKGDNEYTYIKGSFLRENDLIRAGIKKASSVIIFSRSEDKEQMAMDAESILSAMIIRKLNPEIRIIGEILNPDSREHASSFMDDIIIKGDVSSMLIYSSIMIPGIPEFINDLLMSNSISEEDIDEKYASSTYHEFISNMEKENRIVLAFRKQDKIYLRENSDKKIDVDSYIFIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N696</accession>
    <name>A0A1V0N696_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1770</name>
        <name evidence="3" type="ORF">HLB00_01200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000034">
        <property type="protein sequence ID" value="NOL59454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886919.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N696"/>
    <dbReference type="STRING" id="74969.FAD_1770"/>
    <dbReference type="GeneID" id="16025050"/>
    <dbReference type="KEGG" id="fai:FAD_1770"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="101" mass="10809" checksum="8959E531414131EC" modified="2017-06-07" version="1">MTGFSWNWDVFLLVLLALLALSLIVFGVLTAYFGSNKSRMVGGGLLVVGILIGIFVILGSGDIFKVSFITRILEPTIFYIIAAVIGVVIGLLVFLGAIMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6I9</accession>
    <name>A0A1V0N6I9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rbsK</name>
        <name evidence="15" type="ORF">FAD_1861</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143125.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6I9"/>
    <dbReference type="STRING" id="74969.FAD_1861"/>
    <dbReference type="GeneID" id="31677351"/>
    <dbReference type="KEGG" id="fai:FAD_1861"/>
    <dbReference type="OrthoDB" id="26949at2157"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="2"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="213"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="298" mass="32647" checksum="735259F7A539AF69" modified="2017-06-07" version="1">MQGIKVVGSINMDIIMSSARLPETGETIKADKYYMYPGGKGANQAVSVARTGVKPQLIGKIGNDYFAEMITNYLRKENLDLCLTYGDKTGIAMINVESSGKNMITVYPGSNGNMSYEDFHNIELKNSIVMFQQEIPLKTIRDFISSNMENGNLFITDPSPFSEDSYILENSGILTPNETEAQLIAGCTINSVEDAKKASTLISGKYKNNVIIKLGSRGSISNFDGEIKYHKPYNVKTVDTTGAGDCFNGAFASEFLRTGDVDKSMEFANIAAALSTTGYGAFPSFPYRNQIISIMEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1I1</accession>
    <name>A0A1V0N1I1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887027.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1I1"/>
    <dbReference type="STRING" id="74969.FAD_0016"/>
    <dbReference type="GeneID" id="16025162"/>
    <dbReference type="KEGG" id="fai:FAD_0016"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051598">
        <property type="entry name" value="TSUP/Inactive_protease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN MJ0441-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701:SF2">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN YJNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD83951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="249" mass="26410" checksum="E91D2D61B8D3356D" modified="2017-06-07" version="1">MLIIGIAVGALTGITGSSGVLVVVPVLSYMGINFKTSVGTSLLVDVVTTTIVIYVYLRKKTLNPGIGIVLGIGAIIGAQLGSLIAGILPVLPLEIIFTAMAAYMSYYVIKKSYNIDSHGVRKMELSRNLALIIGFALSIPVGILTGVIGTSGGIMFVLIIMVFFSMKAQNMVGTATLAMFLSAASGSIGYYDIGHIDFLAAILIGVVALVSGYYFSIFAHKIKQKYIYRFIGVVFIIVVISEIVKIVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1N6</accession>
    <name>A0A1V0N1N6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0068</name>
        <name evidence="4" type="ORF">HLB00_07365</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141287.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1N6"/>
    <dbReference type="STRING" id="74969.FAD_0068"/>
    <dbReference type="GeneID" id="84218558"/>
    <dbReference type="KEGG" id="fai:FAD_0068"/>
    <dbReference type="OrthoDB" id="15030at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049:SF24">
        <property type="entry name" value="CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="160" mass="18002" checksum="445F9D7213C8E15F" modified="2017-06-07" version="1">MGKRVSESDVTSEIIVLPGDTNMFGDLYGGRLVEWMDNIGSITAFKHSRKKVVTGSIDNLFFLSPIKLGYIVHLHSFVTYTTKSTMEIEIDVSSENVTTSKSNVTTRAFFTYVALDENGHATEIPEIIPENDIERKRFVDGEKRLELRLQALKSVKADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1P1</accession>
    <name>A0A1V0N1P1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141370.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1P1"/>
    <dbReference type="STRING" id="74969.FAD_0142"/>
    <dbReference type="GeneID" id="31675654"/>
    <dbReference type="KEGG" id="fai:FAD_0142"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18159" checksum="505F7881F60CED4D" modified="2017-06-07" version="1">MKKWILVLGVVMLIVGVSMYVYSGMEKPKISENNFTVKGNEYISKNISVDSKHFIISITNPVTSSGLVPSKDIGNVTNTTDLSALSLPTYTSFGNIKEYRNMTEGSYAFIEFTGSHPATSITYGPTGYLVYIGYVADFSTFLILIGIIVAIAGILLNNKFRLRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1P7</accession>
    <name>A0A1V0N1P7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="12">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">thrS</name>
        <name evidence="14" type="ORF">FAD_0111</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141347.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1P7"/>
    <dbReference type="STRING" id="74969.FAD_0111"/>
    <dbReference type="GeneID" id="31675623"/>
    <dbReference type="KEGG" id="fai:FAD_0111"/>
    <dbReference type="OrthoDB" id="372136at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000002">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF44">
        <property type="entry name" value="THREONINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="232"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="668" mass="77171" checksum="1BF68D9A8EDC4741" modified="2017-06-07" version="1">MDSKQLFNIHKGKQFQDAVPEKSGHSIVAARFLNKLYDLSDVAPDNGEVEFIQINSPEGEKILLHSTAHLLANAIVKLYPNALPNTSNESEDTFYYDFNMKPVSIEDFPLIEEKMQELVQANIPITRKILPKNEIIKEFSHNKYKLDKINENVPDGENSSIYIQGNYKEFCRGPHVPSTGYIGAFKLLSISSTNYEGDVNKDKMIRIYGTAFPDKKQLKAFLLRREEAIKRDHRKIGQEMDLFTFDNERAPGMPFYAPNGAIIRNELINYMKELNEKSGWEEVWTAHAFKDIIWKQSGHYYKYKDDMFLFTLPNGDNYGLKPMNCPGHIAIFQRSVYSYRDMPVKYSEAGTVYRYEKSGEMGGLTRPRGFTIDDGHGFVREDQIFDETISLLKIIPSIFKTILGTEEITYDLSVMDKQHPENYLMSYECSSCGEKFMLRAAAQEYKCPACGSEQLNSDFSMWDNATENLRKALEELKLKYTEYPGEAAFYGPKIDVHIKDALGRLWQLSTIQIDFFMPANFDLYYIDKNDTKVRPVIIHRAIYGSYERFIAILLEHFNGKLPLWLTPLQAYIIPVSEAYNEYATEINKKMREKGIRSKVDISDGTISKKIKLIRTMRPSYILVVGEKELANNTLSVRNRKDKTREYGMDEFMGIMAEEIREKKIDQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Q7</accession>
    <name>A0A1V0N1Q7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type peptide transporter, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141316.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Q7"/>
    <dbReference type="STRING" id="74969.FAD_0093"/>
    <dbReference type="GeneID" id="31675605"/>
    <dbReference type="KEGG" id="fai:FAD_0093"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="273" mass="30319" checksum="0596194ED0761155" modified="2017-06-07" version="1">MRINLRRALIFISSLVIFLYLLVFVLDIVYPEYLGVHNLSTLLSFRYGNGIAPHSPSLSSGWELYLGTTYDSIMLLPALLGSLKFDFTVMLASLLISSVAGIAIGFTAAKIGGGYRKAIIYITKIFSSAPYILVMLLVLYVARPMEIGIIIAISTGWSPFYILRSIKFFDDNTGNRQQYSYKKILAGFAPYFITDLGAITGVVTIITYFGFYFHNPFIVDIGNIMYLNGNISTFIQSGVWWVIIFPLAFITVFIGFAALLSYELNGGTDDATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1T7</accession>
    <name>A0A1V0N1T7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887130.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1T7"/>
    <dbReference type="STRING" id="74969.FAD_0123"/>
    <dbReference type="GeneID" id="16025269"/>
    <dbReference type="GeneID" id="31675635"/>
    <dbReference type="KEGG" id="fai:FAD_0123"/>
    <dbReference type="OrthoDB" id="56740at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="88" mass="9701" checksum="AFA46EF65133B42C" modified="2017-06-07" version="1">MDMIEIKKGGVYTVVSSSGDDKPMITEGEYVGYAILGEEGSLVLRVSSEGKSKLRLIPVGTISYIEFDEENIVSKNKEDDKGKTTYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1T8</accession>
    <name>A0A1V0N1T8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps17</name>
        <name evidence="7" type="ORF">FAD_0168</name>
        <name evidence="8" type="ORF">HLB00_02260</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000069">
        <property type="protein sequence ID" value="NOL59657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887173.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1T8"/>
    <dbReference type="STRING" id="74969.FAD_0168"/>
    <dbReference type="GeneID" id="16025317"/>
    <dbReference type="KEGG" id="fai:FAD_0168"/>
    <dbReference type="OrthoDB" id="10698at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_A">
        <property type="entry name" value="Ribosomal_uS17_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019978">
        <property type="entry name" value="Ribosomal_uS17_archaeal"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="106" mass="12138" checksum="D394756B940FF84C" modified="2017-06-07" version="1">MNNIGIDVKPPEKECNDINCPFHGELPVHGQILEGKVVSVKMKRSVVIRREAKVYVKKYERYITKFTKYHAHLPDCIDVKVGDSVKAAECRKLAKTIDFVVIERVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1W0</accession>
    <name>A0A1V0N1W0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpl14p</name>
        <name evidence="6" type="synonym">rpl14</name>
        <name evidence="8" type="ORF">FAD_0169</name>
        <name evidence="9" type="ORF">HLB00_02265</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000069">
        <property type="protein sequence ID" value="NOL59658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887174.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1W0"/>
    <dbReference type="STRING" id="74969.FAD_0169"/>
    <dbReference type="GeneID" id="16025318"/>
    <dbReference type="GeneID" id="84218658"/>
    <dbReference type="KEGG" id="fai:FAD_0169"/>
    <dbReference type="OrthoDB" id="23569at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000007">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019971">
        <property type="entry name" value="Ribosomal_uL14_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03673">
        <property type="entry name" value="uL14_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="132" mass="14072" checksum="9132CD864A1A6BF7" modified="2017-06-07" version="1">MKGISGNESRGLPLGAVIPCADNTGAKMISLIGVKDLHTVARRIPAAGVGTLFIASVRKGTPEMRAKVVYAVVVRQRRPYRRADGNIIEFEDNAAVLVTPEGEVRGSEIKGPVAREAAERWPRIAAIASTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1X5</accession>
    <name>A0A1V0N1X5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trpS</name>
        <name evidence="10" type="ORF">FAD_0211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1X5"/>
    <dbReference type="STRING" id="74969.FAD_0211"/>
    <dbReference type="KEGG" id="fai:FAD_0211"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008926">
        <property type="entry name" value="PRK12285.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF5">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="437" mass="49315" checksum="540B6BBB21C6B743" modified="2017-06-07" version="1">MHTQSGVMINPWSSAQYFDYEKLIKEFGIQRPDNYFDYFMFRRHLIFGQRGIDYLEYSIKNKIKFNAMTGLMPSGKMHLGNKLTIDQIIYFQSLGADVYIAVADLESYATRGISFDKARNIAINEYIANYISMGLKPCRIYFQSENYDTQSLSFVLSNETNMSELKSIYGLTDSSSILHVNAPIIQAADVLHTQLGHLGGPRATIVPVGIDQDPHIRLMRDIAKRLRVYNVKIEDNKISIYIKGSDDPADKINSAISVLGNSGYECMPNYEYRAIYVKNSTGEDKIKIDMMLAIEESRINDYAFIEPSATFQKLETGLKGGKMSSSVPDSLISLNDTGEEATRKIKHAVTGGKQTIEEQKKYGGNPDICPVFELYKYHNSNDKYVTRVYEECKGGVRMCGPCKIEAAENISGMLKTLAEKKDESLGKLDDYLIKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Z5</accession>
    <name>A0A1V0N1Z5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF106 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0184</name>
        <name evidence="7" type="ORF">HLB00_02345</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000070">
        <property type="protein sequence ID" value="NOL59674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887189.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Z5"/>
    <dbReference type="STRING" id="74969.FAD_0184"/>
    <dbReference type="GeneID" id="16025332"/>
    <dbReference type="KEGG" id="fai:FAD_0184"/>
    <dbReference type="OrthoDB" id="84619at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038978">
        <property type="entry name" value="MJ0935"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="228" mass="26779" checksum="443160FDBA92F723" modified="2017-06-07" version="1">MQQGNNRPAQNPQMTKFMMIEFVFMFAGLGLIFIISDPSIRNPLGHYLNYVFMPLLGFNYELPILTLMLTGIVLGLISSIPRYFFTDWLKMGKTQMISKAYQKAMREAYRSGDRARQQKLQKLSMQRQMDQAALSMNTMKPLMVTEIFFFLIFIWLYVFMLTIHYQYVSMPWDLNLNIVTSKIYIMPLWMALYTLGNLAVGYFVTSIMKFVDFTYKLRKLDDDSARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Z8</accession>
    <name>A0A1V0N1Z8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="8">GSA</shortName>
            <ecNumber evidence="8">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="8">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemL</name>
        <name evidence="10" type="ORF">FAD_0196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141397.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Z8"/>
    <dbReference type="STRING" id="74969.FAD_0196"/>
    <dbReference type="GeneID" id="84218684"/>
    <dbReference type="KEGG" id="fai:FAD_0196"/>
    <dbReference type="OrthoDB" id="6524at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000021">
        <property type="entry name" value="Glutamate-1-semialdehyde 2,1-aminomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000818">
        <property type="entry name" value="PRK00062.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="420" mass="46095" checksum="E110C3B9F6CAC7A7" modified="2017-06-07" version="1">MRSSELFKEALELFPLGVNSPVRYYSPEPVMFAQGHGSKILDVNGKEYIDYSLGFGPMILGHANPDVSNHIKSQVDKGILFGSISENEIKLGKTIKNAVGSIERLRFTNSGTEATMHAIRLARGFTGKKYIVKMEGGYHGAHDYALIKSGSGTMTFGVPSSAGVPKEVSRTVLVGRYNDAESIEKLFKEHRNEIAAVITEPVLGNIGVINPENDFLNSLREITEKYSSLLIFDEVITGFRFGFKGYQDIAGIKPDLTTMGKIIGGGAPVGMFGGREDIMAHVAPQGDVYEAGTFSGNPLTMAAGIATLDQLKSKDYSAITNYAARLEEKLNSLISEYNIDATINRCHSMFQIFFNKNKVTDYKGATASDTEKFNKMFHMLLEKGIFFPPSQFETEFVSFAHSETDLESTVDAFSSVLKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N223</accession>
    <name>A0A1V0N223_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0220</name>
        <name evidence="3" type="ORF">HLB00_06575</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000234">
        <property type="protein sequence ID" value="NOL60497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_171481739.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N223"/>
    <dbReference type="STRING" id="74969.FAD_0220"/>
    <dbReference type="GeneID" id="84218710"/>
    <dbReference type="KEGG" id="fai:FAD_0220"/>
    <dbReference type="OrthoDB" id="56815at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="52" mass="6164" checksum="21FFA6F00BB5A059" modified="2017-06-07" version="1">MKEADKTKNVQELSREVKDMRKEIDSMKELLGGLIKVMMDHDDQFSDEDEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N265</accession>
    <name>A0A1V0N265_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable octanoyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lipB</name>
        <name evidence="10" type="ORF">FAD_0320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4 5">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N265"/>
    <dbReference type="STRING" id="74969.FAD_0320"/>
    <dbReference type="KEGG" id="fai:FAD_0320"/>
    <dbReference type="OrthoDB" id="57380at2157"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="9">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4 6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="4 8">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="224" mass="25035" checksum="40C9A3113E8CC093" modified="2017-06-07" version="1">MNSSVMEEKKPVERIYDPGIVGYIEALNFQKKMHALVNEGISGDVFIFLQHPDVYTAGSHYSGDLSNAIKVNRGGYMTYHGPGQLVAYYIVNMKRRNINALGLIKIIQDSIISLLEAYGIDGKPMLNEKTGVWVGDKKICSIGIGIDRFTTMHGMGLNISTDLKKFNVINPCNFSPDIMTSMDNISGIKNDFNSVKEKFIDITKKNFEIEDCERYTSIGDTVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N281</accession>
    <name>A0A1V0N281_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <shortName evidence="14">IOR</shortName>
            <ecNumber evidence="3 14">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FAD_0341</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] + CoA = (indol-3-yl)acetyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14 15">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 14">Heterodimer of the IorA and IorB subunits.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="3 14"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141514.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N281"/>
    <dbReference type="STRING" id="74969.FAD_0341"/>
    <dbReference type="GeneID" id="31675850"/>
    <dbReference type="KEGG" id="fai:FAD_0341"/>
    <dbReference type="OrthoDB" id="19071at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02008">
        <property type="entry name" value="TPP_IOR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000039">
        <property type="entry name" value="Indolepyruvate oxidoreductase subunit IorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03336">
        <property type="entry name" value="IOR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710:SF7">
        <property type="entry name" value="INDOLEPYRUVATE OXIDOREDUCTASE SUBUNIT IORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="593"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR006439-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ARD84262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="623" mass="68243" checksum="DF27CFC0ACCFAD7C" modified="2017-06-07" version="1">MVKFDANMVDNSENEVLFLLSNEAIARGAVEAGVRVATTYPGTPSSEVGDTLSHIAGKSGMKFQFSINEKVAIETAFAASISGQRSMVFMKHVGLNVASDPFMSIAYTGVRAGMVVMSADDPSMYSSQSEQDNRHYADLAHVPMIEPSNPQEAKDFLVLAFDLSEKFKLPVLFRTTTRVSHMRGAVTPGKIREGQPDTGVFIRDIHEFVCLPSNSYTLKEKLIEKEHELKKESDISPMNRIIRKGTGEYGIIASGAAYNSVMDVISEYDLDISVLKLGFTNPLPESAIVKFISDNKKVIIIEELDPYLEYKIRTIAQMNKLDSTIFGKLDGYFSESHEFTPDTVAHSLSRIMGFAVQDVPENKLVLPARPPVLCPGCPHRATYYAVKRAVKMMNKTDTIYASDIGCYSLGLYDPYEEADTMISMGSSIGMANGFAMSTKQKVIAFIGDSTFFHSGIPPLINAVHNKLNMLVMVLDNGTTAMTGQQPNAGENFSPPGDELPPVSIENIARSIGVADVQIVDPYDIKETLKAVTKALRENTLSVIVARRECAILRDKAMQKTHRVITYTVNQDKCGKCMNCVENFACPAISIEGGNIKIDSNICDGCGVCAEPYVCPFKAIEVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N299</accession>
    <name>A0A1V0N299_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141535.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N299"/>
    <dbReference type="STRING" id="74969.FAD_0359"/>
    <dbReference type="GeneID" id="31675868"/>
    <dbReference type="KEGG" id="fai:FAD_0359"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="290" mass="33509" checksum="1728B482F5AEB2DA" modified="2017-06-07" version="1">MQVRDNINKYLIPVLAAIIFIPDFIMFYALGNVIYNSTVFYFVILFTVEMILSKFIKLYGFLIFLFTLMAVLLLYIKTLYYYTHIVKRYFYYLPNMPVTTRLIYTFVVILIIGILMEGLFARKFWHLISSYIVVSGTMLMQMATLAYMHAGGININYNSYMTGLYSVSVLEYKSVLSLFLHGYQTYLPLYKLVLPMAFPLAIGYMVSVIGTILWLYSIDSSKTDNVFGYFSIVIGLAIGYLFFLMIHYVTPVKFEFLSIAIAVVSVYLIISYSNSKSKDITVKADIDYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2B6</accession>
    <name>A0A1V0N2B6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="2 8">6.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">leuS</name>
        <name evidence="12" type="ORF">FAD_0309</name>
        <name evidence="13" type="ORF">HLB00_04595</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2 8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000157">
        <property type="protein sequence ID" value="NOL60114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141481.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2B6"/>
    <dbReference type="STRING" id="74969.FAD_0309"/>
    <dbReference type="GeneID" id="31675818"/>
    <dbReference type="KEGG" id="fai:FAD_0309"/>
    <dbReference type="OrthoDB" id="23906at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.20">
        <property type="entry name" value="Class I aminoacyl-tRNA synthetases (RS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.720">
        <property type="entry name" value="leucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="9"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="686"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL60114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="902" mass="103828" checksum="B7A79B056C1D6F5A" modified="2017-06-07" version="1">MDREIEEKWRDEWAKSHIFEPSIDDTKPKFFVTVPWPYSNGSLHVGHGRTYTLGDIIARYKRLTGFNVLFPMGFHESGTPILAFSERIRNGDPGTIKLYRNYLMEYENPSDIDGIIESFKNPQNIADYFSRVIVKDFMDLGYSIDWTRKFTSADPFYQEIVKWQFMQLESKGLIKKGKYPILYSINDENAVGEDDIKDGDTDKVTIEEFTGVLFKGDKYYLIAASLRPETLFGVTNLWINSDAQYAMVRYNNMDVVMSADGYTKFSLQHDGIEYIGSVNPEEIIGEKFNVPFQDTPVDVIGADFVDPDNGTGVVYSVPGHSIFDYLYYGRNNIKNSIKKVVEVKSKMSVESLVKKYGLEHNESKLKEATQELYKEEFYNGVLINSGPYSGMNVAAGREAIKNDLISKNMAVIFYETTRKAVTRSGSRVIVAVLKDQWFIDYSPEWLKNKAHEVINSMRFYPELYRKLMMDAIDWLKERPCARKRGIGTRLPFDENWVIESLSDSTIYMLAYTNKKELKNIYDRLHSIPGDILDYVLLGKEIRNRYDDYIMENARSAKKEFDYWYGNDLRITAPPHISNHLAFFIMNHAAIFSGSKLPGGLMISGLVISNGAKISKSKGNVISLLEIINRYSADIYRLFMAAGADISSLLDWNEKDISSVIKRYSYFIGLLDGYSGDNPGDGYIYDWFRSSFYKNLKNYLGYMESMNIRDACISIFYNVMNDLKNVENHGGNINSALKPILADWLKALSPVIPFSCEEYWHRHIDNKTFVSVQPIDTNIESRIDSGIIKSETYLNRVISDIREIIKIIRIKPEKAVITVYGTKQEDFIKGYMANSLEREYKSMIPDYMKNKNRIDPEPVDEYSIISKNKEYIESVLKIEIAVVKSSEILKKNPWPGRPLIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2E5</accession>
    <name>A0A1V0N2E5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0358</name>
        <name evidence="4" type="ORF">HLB00_08495</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000318">
        <property type="protein sequence ID" value="NOL60861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887377.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2E5"/>
    <dbReference type="STRING" id="74969.FAD_0358"/>
    <dbReference type="GeneID" id="16025523"/>
    <dbReference type="KEGG" id="fai:FAD_0358"/>
    <dbReference type="OrthoDB" id="3263at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33608">
        <property type="entry name" value="BLL2464 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33608:SF6">
        <property type="entry name" value="BLL2464 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="201"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="431" mass="49708" checksum="A3E36AAC7AD90B23" modified="2017-06-07" version="1">MIRKAGYAILAVLTYGILESVLLGYKYYIIFTILTFFMVAFDVVYFNISGSKAINHISVTRRYDTIKFRKNRKFQITLLFENKNPFPVSVHFFDEAIDVLEISGKTGGNITIPENGSYETSYSTIPRYIGKYKLGNITISISDLFHIASVNKTIAMDMAIRISPSTRDIKSIRSEMISSFIYTQGNHYSHHVGQGYNLYGVRPYTFEDDPRFIVWSRYSEGNEDSIMVKEMEEEREITTIFIIDYSIAMNYGDIDRVYDSSIVDIINSAHFMAKNRDNVGFLLYSSKINVYIPPGKSGESISRLEKSVSSILPDGEFRIGDALKELQLKQKKHFLTFIITASRSYIPRKFLNYSSTSIFLIDSESYYEYSPTGKFDGLLIQNMRKKDLENLSRNVKEIRDYGIRCTYVNRKNMLSKIMVEYNYRRSMNAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2F2</accession>
    <name>A0A1V0N2F2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="8">SRP receptor</shortName>
            <ecNumber evidence="8">3.6.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ftsY</name>
        <name evidence="11" type="ORF">FAD_0397</name>
        <name evidence="12" type="ORF">HLB00_05080</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141568.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2F2"/>
    <dbReference type="STRING" id="74969.FAD_0397"/>
    <dbReference type="GeneID" id="31675906"/>
    <dbReference type="KEGG" id="fai:FAD_0397"/>
    <dbReference type="OrthoDB" id="372188at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000053">
        <property type="entry name" value="Signal recognition particle receptor FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="10">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="262"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL60207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="311" mass="34547" checksum="2A97A271753A754E" modified="2017-06-07" version="1">MFDKLKKKFSDIFSGNRENGPKDSLTATRDSVAPQKEKTIRRDELESTIEETLLEADVSYDATEEIIEKLKANLGKLKRKIDYPAVEEELKSVVRDVIQHNNKDAVNLLTVEKKPFVILFLGINGTGKTTTIGKLAYYLKSNNKSVVLSASDTFRAGAIDQLNILAGNVGVEIIKHDFRSDPASVAFDAIEHAKARKMDYVLIDSAGRMQTNKNLLDEMKKIKRVAKPDMTILVLDAMIGQDVINQALTFSSEINYDGVIVTKLDTDAKGGSIISISAGIKKPILFVGIGQEMDDIIPFDVEWYLKKIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2H5</accession>
    <name>A0A1V0N2H5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0384</name>
        <name evidence="3" type="ORF">HLB00_00610</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000016">
        <property type="protein sequence ID" value="NOL59340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887405.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2H5"/>
    <dbReference type="STRING" id="74969.FAD_0384"/>
    <dbReference type="GeneID" id="41484105"/>
    <dbReference type="KEGG" id="fai:FAD_0384"/>
    <dbReference type="OrthoDB" id="377596at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="64" mass="7601" checksum="6FC67467B468D3A1" modified="2017-06-07" version="1">MKTTNIIYLIGIIQLVVVDPIMWYFTQVHPFRYESLWAITLVINLFLFAAIIFLMLQRTIKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2H9</accession>
    <name>A0A1V0N2H9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887404.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2H9"/>
    <dbReference type="STRING" id="74969.FAD_0383"/>
    <dbReference type="GeneID" id="16025550"/>
    <dbReference type="KEGG" id="fai:FAD_0383"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="112" mass="12709" checksum="F9455A685F3DBA90" modified="2017-06-07" version="1">MDKKSIYLYYYSMIIYLFGSVPFILYAVLIKPIGAMYHEHPFQMVSPVFGNFGVYEEGLLVITLVMVILSIILYAISLMHNRGRHGKISSRTIIAPILLYIFTFAVIGVAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2J3</accession>
    <name>A0A1V0N2J3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2J3"/>
    <dbReference type="STRING" id="74969.FAD_0390"/>
    <dbReference type="KEGG" id="fai:FAD_0390"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013603">
        <property type="entry name" value="TRASH_TR_C_prok"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08394">
        <property type="entry name" value="Arc_trans_TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="168" mass="19751" checksum="3F3A601A8CD5D04D" modified="2017-06-07" version="1">MHSNMNRNESRVLKLLFENSKMPISEISDRLLLNRNTVSKIITKLNREYIERYTITLKERENSLYIIAEMENIDGLDDDIIEYYKMANGNYLVVMNKDSLSGNLQYKNLNIAYKRVLNNDMEKVDLYCDYCDSIISGKPHVLDVNHNKLYFCCDTCKSEYIQNHNATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2K3</accession>
    <name>A0A1V0N2K3_9ARCH</name>
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        <submittedName>
            <fullName evidence="5">Thiosulfate sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887522.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2K3"/>
    <dbReference type="STRING" id="74969.FAD_0467"/>
    <dbReference type="GeneID" id="16025671"/>
    <dbReference type="KEGG" id="fai:FAD_0467"/>
    <dbReference type="OrthoDB" id="8628at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="SEGREGATION AND CONDENSATION PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298:SF2">
        <property type="entry name" value="SEGREGATION AND CONDENSATION PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="159" mass="18596" checksum="950B0EDA5BCEF845" modified="2017-06-07" version="1">MNEISRRIEAILFSSKEPVKASEIAEYLNITNAEFIKAIKEISRNYENIESSLIVGQFGNSYKIKLSEEFVPVVDPFIEKEFTEKQLAMLSYIYKMNGEAISGNLRDNFGYAYKEDLEKLKKGGMVSSRKYRNTHKYKVTTEFHRKFNINKRTLRAEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2L5</accession>
    <name>A0A1V0N2L5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MazG superfamily nucleotide pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0415</name>
        <name evidence="2" type="ORF">HLB00_04990</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141580.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2L5"/>
    <dbReference type="STRING" id="74969.FAD_0415"/>
    <dbReference type="GeneID" id="31675924"/>
    <dbReference type="KEGG" id="fai:FAD_0415"/>
    <dbReference type="OrthoDB" id="147562at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052555">
        <property type="entry name" value="dCTP_Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46523">
        <property type="entry name" value="DCTP PYROPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46523:SF1">
        <property type="entry name" value="DCTP PYROPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029826">
        <property type="entry name" value="UCP029826_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="125" mass="14727" checksum="1E1996C04A8460D1" modified="2017-06-07" version="1">MSDIKELEGIASEFIDKRDWRKFHTIKDLAMNCSVESNELLEILLWRDKEFENNILNGKDNKSLEMIKNEVSDILFSCFAIADHLHFNLEGAYRQKMKELDKRYDPDKVKGKLVKIPSPDHKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2P9</accession>
    <name>A0A1V0N2P9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2175 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0456</name>
        <name evidence="2" type="ORF">HLB00_10025</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000442">
        <property type="protein sequence ID" value="NOL61154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887509.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2P9"/>
    <dbReference type="GeneID" id="16025658"/>
    <dbReference type="KEGG" id="fai:FAD_0456"/>
    <dbReference type="OrthoDB" id="57156at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018686">
        <property type="entry name" value="DUF2175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09943">
        <property type="entry name" value="DUF2175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL61154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="99" mass="11475" checksum="0FCB178A8226EC9C" modified="2017-06-07" version="1">MEYGCYTCNKIIKTGEKFTFTKEGPVHLDCFVATQRKKVPEEKQEYLRNLSMVLDYELTYLVELLGLKSDDKPTSEFIKRRITAIEKQAGETTGLIYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Q4</accession>
    <name>A0A1V0N2Q4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-aminoadipate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lysW</name>
        <name evidence="1" type="ORF">FAD_0504</name>
        <name evidence="2" type="ORF">HLB00_00470</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000013">
        <property type="protein sequence ID" value="NOL59313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887562.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Q4"/>
    <dbReference type="STRING" id="74969.FAD_0504"/>
    <dbReference type="GeneID" id="58788985"/>
    <dbReference type="KEGG" id="fai:FAD_0504"/>
    <dbReference type="OrthoDB" id="159847at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13946">
        <property type="entry name" value="LysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041070">
        <property type="entry name" value="carrier_LysW_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393:SF2">
        <property type="entry name" value="ALPHA-AMINOADIPATE_GLUTAMATE CARRIER PROTEIN LYSW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393">
        <property type="entry name" value="LYSINE BIOSYNTHESIS PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21344">
        <property type="entry name" value="Zn_ribbon_LysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="57" mass="6082" checksum="348BC083FC432878" modified="2017-06-07" version="1">METKCKICGEKINVPDDSMAGELIECGSCGMSYEIASIKADGVEIKPAENVGEDWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2U2</accession>
    <name>A0A1V0N2U2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0510</name>
        <name evidence="2" type="ORF">HLB00_00505</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000014">
        <property type="protein sequence ID" value="NOL59320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887568.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2U2"/>
    <dbReference type="STRING" id="74969.FAD_0510"/>
    <dbReference type="GeneID" id="16025714"/>
    <dbReference type="KEGG" id="fai:FAD_0510"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="258" mass="29896" checksum="B967D858EC274BC6" modified="2017-06-07" version="1">MLFAPDKNNSKNSPIFKKSIIGTMKHNSSNFLVFIAGIRGHIMPLHFYRGMARSIKNISGDSPISYTDSCINWLQALAVYKYSSLIYWKKHKNAREARIFTGIFSKERKRYRILSDFLFISIVNAFPLAASLAFEYYNEFSPDKKFEIEIQQYIGKSGIDNDSCKRFFLEIINSAEPSSKWHRHVLSLSSELYGENNAYKDVFTAYIVYILYKLNNFNISSTLKCTYKKSPVEVAMELYKNREAIDSYLSLIQLHGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2U4</accession>
    <name>A0A1V0N2U4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0560</name>
        <name evidence="3" type="ORF">HLB00_00700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000020">
        <property type="protein sequence ID" value="NOL59358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887617.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2U4"/>
    <dbReference type="STRING" id="74969.FAD_0560"/>
    <dbReference type="GeneID" id="16025767"/>
    <dbReference type="KEGG" id="fai:FAD_0560"/>
    <dbReference type="OrthoDB" id="379418at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="148" mass="16821" checksum="0B0394ADB1263EB2" modified="2017-06-07" version="1">MANVYLAIGVIFFIMSALSFTLGIYYLAIPLLIIFLILMFLYYRTSGRHVNKKVSSITYDGIMQTGLSKIEKGTFYIDKEKFISIMSKINDLVSSQGTMPEFGLDAIYVDFNKQESAEKFVGLIQQRGVKAATVQERSIWKVKIEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Y6</accession>
    <name>A0A1V0N2Y6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein FAD_0522</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141653.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Y6"/>
    <dbReference type="STRING" id="74969.FAD_0522"/>
    <dbReference type="GeneID" id="31676029"/>
    <dbReference type="KEGG" id="fai:FAD_0522"/>
    <dbReference type="OrthoDB" id="372162at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="271" mass="30874" checksum="78B9C0753645C333" modified="2017-06-07" version="1">MDNTREPHVSGGFYPDDYEALMDSIKGSMDITMPDIRYKKLIGAIVPHGQYMYSSHTAAYAYKIIQESKKRTFLIIGPNHSKFPAYPAIYLDGYWSTPLGYAKVNSELSERLLLKSDIIHDDKEAHITEHSIEVQLPFLQYLFKSNFTFTPLILGNQGAAIARNIAETIESLEEKPFVLISSNFNHYLPYDKNNELDQILINDIQEMRTLKFYQDIEKYGITACGYGAIAILMLITKNMKGKIALLNHSNSGDYSKDRKRVVGYSAMIAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N301</accession>
    <name>A0A1V0N301_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0555</name>
        <name evidence="2" type="ORF">HLB00_00725</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000020">
        <property type="protein sequence ID" value="NOL59363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887612.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N301"/>
    <dbReference type="STRING" id="74969.FAD_0555"/>
    <dbReference type="GeneID" id="16025762"/>
    <dbReference type="KEGG" id="fai:FAD_0555"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="60" mass="6971" checksum="70D23517818A615F" modified="2017-06-07" version="1">MYNKNENITKKQLSFVNDLIKRGEENQKIVDDYVKSLKKGSIEELSKKEASSLLDKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N317</accession>
    <name>A0A1V0N317_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141735.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N317"/>
    <dbReference type="GeneID" id="31676137"/>
    <dbReference type="KEGG" id="fai:FAD_0632"/>
    <dbReference type="OrthoDB" id="56512at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.600">
        <property type="entry name" value="Thermoplasma acidophilum protein TA0956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021595">
        <property type="entry name" value="TA0956"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038394">
        <property type="entry name" value="TA0956_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11513">
        <property type="entry name" value="TA0956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="111" mass="12943" checksum="1E3074966CD4C8F0" modified="2017-06-07" version="1">MVTCVMYNLKMSETHPSTICVLASKFEDSFEDLIEVLTSPLPDESLEEFIESYARTDEIMPEDKTIGFVIINKEKKVASLNFSEKYFDEKKLDEILEKYKNMGYKTEVEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N326</accession>
    <name>A0A1V0N326_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0641</name>
        <name evidence="2" type="ORF">HLB00_07910</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000295">
        <property type="protein sequence ID" value="NOL60750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887701.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N326"/>
    <dbReference type="GeneID" id="16025851"/>
    <dbReference type="KEGG" id="fai:FAD_0641"/>
    <dbReference type="OrthoDB" id="382163at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="126" mass="13936" checksum="0C710EF9EB1E8C30" modified="2017-06-07" version="1">MCSAISLGYSDLIDSFRGGNLDGVYLVVATVMSYTGIIRAVDSDSIIMDIPLKFYAGDNVMYTPVIIGRDEVLEIKEVPISGYIKIKTKNDGEFAGEIETAFSNRMVIDSNGKNIIVYYQDFVNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N344</accession>
    <name>A0A1V0N344_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0664</name>
        <name evidence="2" type="ORF">HLB00_07625</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000281">
        <property type="protein sequence ID" value="NOL60697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141769.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N344"/>
    <dbReference type="STRING" id="74969.FAD_0664"/>
    <dbReference type="GeneID" id="31676166"/>
    <dbReference type="KEGG" id="fai:FAD_0664"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="355" mass="40980" checksum="BDCFB0E7C94DACD7" modified="2017-06-07" version="1">MRIFNPGPEYSQIISYLLTGKSAREIGRIMGYKSGGTVSKKIKRLINHGYLINHTGPDNRFYSITLKGYSIIGNKREDNSPTQSGKVEALTENSDKFYRLHALQIKYWLKTPLPAENIHIISFKDHPTHLRNLRNHSDLIVEFKDFNVTVSTRAIKFTNLEVRMPYKEVNDPQILLTKAMALIEPEVEHIESLLSKHIPGLKLQRLANNVLDAVVTRGEIAIENDELAINVGKIQKDTGEKLRIYDPDDGKISEIVDFSKGPAEFESVHPKKLIENLEIYKQFLDDLNSGKFYDRINKIVEVQEKTMQIQEKQEEIQKNAFSQFDERINEHLNLVNNLATQFFHALDELKNYMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N360</accession>
    <name>A0A1V0N360_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="8">AdoMetDC</shortName>
            <shortName evidence="8">SAMDC</shortName>
            <ecNumber evidence="8">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="8">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="8">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="8" type="primary">speH</name>
        <name evidence="9" type="ORF">FAD_0595</name>
        <name evidence="10" type="ORF">HLB00_10070</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="8">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000443">
        <property type="protein sequence ID" value="NOL61163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887652.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N360"/>
    <dbReference type="STRING" id="74969.FAD_0595"/>
    <dbReference type="GeneID" id="16025802"/>
    <dbReference type="KEGG" id="fai:FAD_0595"/>
    <dbReference type="OrthoDB" id="114016at2157"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866:SF2">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 8" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5044508779" description="S-adenosylmethionine decarboxylase beta chain" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044508780" description="S-adenosylmethionine decarboxylase alpha chain" evidence="8">
        <location>
            <begin position="64"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="8">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="8">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="8">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="8">
        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="8">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL61163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="130" mass="14419" checksum="73E5FA1C876545BC" modified="2017-06-07" version="1">MKVAVGVHIIADLYGVDSELISSADGISPIIESAIKEGNLTEISSQYYQFRPMGASGIALLAESHLSFHTWPEHGLVTLDIYTCGEHSNADRAFNYLLNVLHPTSIEYKKLERGSKIEENVKIENPQMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N363</accession>
    <name>A0A1V0N363_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Purine-cytosine permease related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:cytosine transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Hydantoin permease"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOSINE TRANSPORTER CODB"/>
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        <property type="entry name" value="Transp_cyt_pur"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="244"/>
            <end position="264"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="359"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="478" mass="52513" checksum="28257B2BF1E566E1" modified="2017-06-07" version="1">MVVKSFDNDVVEHRLEVVGVNPIPNHARTMSSRKIMIFWAMASASALTPIVGLELYNMGLPFATIAIIVALLIGIIPAGLVAEMGRQIPVPSLVVSRKTYGFMTSGAYSLVFTFLNLGFFGLNDTVGAAIISGLTHSNIIIWYVVMGVIQVVLVLFGAKWLEYFFRYSAPVLIVSYIILAYFLLTTYTINFSMLMHPIGAFTWGAALNFLLGFSILAWSYKISTQTRFGYPYSKEDSSGKKLKYFISSPVGIMIPVLLMGLIGLVGNSVATGGWNIATLSFPGLHGLFGIVVFIAALGVSLAIIHTNAMNLYPATADLLAALQPAFRKKPNEKLAQPIATILLGAGGIILAIAGILAHIETFIDDLASIIFPFTFILIFDWFVHLRHTTKIDDYYNIPRTIFMNLRVDALIPALIGTIIAMFGIGPYDVIFNYFPQALFGSLIGLGIYVAVYYGYSKNHINSKEHYSEKVEYADFEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N376</accession>
    <name>A0A1V0N376_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
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    <dbReference type="STRING" id="74969.FAD_0634"/>
    <dbReference type="GeneID" id="31676139"/>
    <dbReference type="KEGG" id="fai:FAD_0634"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043958">
        <property type="entry name" value="Ta1207"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19020">
        <property type="entry name" value="Ta1207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="310" mass="35542" checksum="6AED17337B62F853" modified="2017-06-07" version="1">MLISETTGINDMECHIKLNIDSFMAQNLKLLGKDYTLFFRKEGDDVYIKTFVDKSFEHMLVPNPDAFQQIDNYFSITEKLKFPIIFEFISSLNSIPTVMMHRPYLSDGMLNIVFSYMHRYSKNVTDAFIPVTSGSKLVADVSIHPSSGALATLLNFSKIRPLSVIRFRIHRDAHDDRKLMDNLESSGSIGRLVTDYIDKKQFRMAVISEKPLELLPGIEKIPGDGNFYWITINNPILGKVMEKAGSRGIYIDTTYFQIEKKHLVITQFIPKIRTIEYMQILFNTSIAEINRNDVAIDIATPLSEHIINFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N395</accession>
    <name>A0A1V0N395_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">succinate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_0716</name>
        <name evidence="16" type="ORF">HLB00_01180</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Berkeley</strain>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000033">
        <property type="protein sequence ID" value="NOL59450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141838.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N395"/>
    <dbReference type="STRING" id="74969.FAD_0716"/>
    <dbReference type="GeneID" id="84217339"/>
    <dbReference type="KEGG" id="fai:FAD_0716"/>
    <dbReference type="OrthoDB" id="144910at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000003">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009226">
        <property type="entry name" value="PRK12576.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="12" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD84622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="NOL59450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="313" mass="35754" checksum="724101B1D9622C83" modified="2017-06-07" version="1">MEEKEITVNVKKYNEKDGAFWKSYKLSVDKYTQMTEVLRRIKSEQDPSLAYRASCHMAVCGSCSMKINGVPSLACRTIALQATDDKNEINLESMDYYPGVRDLITDIDVFYDKMYKVMPRLVADNSVLSGENEQRMTPEDQTEVWKFEECIYCGLCVSACPSVKEDEQFLGPAAHAKGFRFVDDERDTKKQERLDLLMDSAYRCTSCYMCYEVCPQDVQPVIAIKKTKNYLDEYKGNTAITVAARKHDDAIENLISSTGKIKESTLFLKSFGFGEAMRDAVDMLKAGKFKYAFEKDSKVKNMDEIKKLMGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N397</accession>
    <name>A0A1V0N397_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="13">TC-AMP synthase</shortName>
            <ecNumber evidence="3 13">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FAD_0646</name>
        <name evidence="17" type="ORF">HLB00_03615</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Berkeley</strain>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000115">
        <property type="protein sequence ID" value="NOL59921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141745.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N397"/>
    <dbReference type="STRING" id="74969.FAD_0646"/>
    <dbReference type="GeneID" id="84217248"/>
    <dbReference type="KEGG" id="fai:FAD_0646"/>
    <dbReference type="OrthoDB" id="39992at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="15">
        <location>
            <begin position="13"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD84557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="NOL59921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="348" mass="38528" checksum="CF684E52B6928120" modified="2017-06-07" version="1">MTRIIHINNQNENYAIKVCAGIIKNGGTVVFPTETVYGLGADAFNPGACSKIFIAKNRPADNPLIVHISNMKMLDQVAYIDDGLRKKMENIWPSPLTLLLKKKESIPDIVSAGLDTVCVRFPDNKIALELIDASGPIAAPSANISTRPSIVDSETAVEELDGRVDAIIDAGRVRYGVESTILDCTAEPYRLLRAGAFSVEDIESIIGKIYVDPLAKGYNQSDVALTPGLKYRHYAPSKKLFLIENEEEFKKFISSEVSKDFMVLCSKENEKYASGESIVLGGDIYEIAHNLFYDFRYLDNSGKLYGVIQAFPETGIGLAVMNRIRKASFMIVKDKENIDKIYRVINEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N399</accession>
    <name>A0A1V0N399_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Long chain fatty acid CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887696.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N399"/>
    <dbReference type="STRING" id="74969.FAD_0635"/>
    <dbReference type="GeneID" id="16025845"/>
    <dbReference type="GeneID" id="31676140"/>
    <dbReference type="KEGG" id="fai:FAD_0635"/>
    <dbReference type="OrthoDB" id="193284at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015645">
        <property type="term" value="F:fatty acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051087">
        <property type="entry name" value="Mitochondrial_ACSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605:SF10">
        <property type="entry name" value="ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="455"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="559" mass="63179" checksum="DC07200A9488D3A0" modified="2017-06-07" version="1">MEFIDFYKKFIFSNSKGRNTMLGELKSLKINEPFNWVSEIFEKLFAGNDKDAIIYINEGTGEERRISYRKLYESYNQFINFLRAEGINKGSSVYIMAGSIPEQWVVMMGALKAGFIVIPTAANLTEYELNYRFSQDSPDVIISDEASAEKLEHVLNTEALKLVIGNREGWISFDEIYKMEINAEPAELGKDDLFIKYFTSGTTGMPKAVRHSSILYPIGQLSTVTAIGIRPEYIHNNLSSPGWAKFAWSSFFAPLCAGATVLSIDYRGRLNSSRYLELIDRYKVNTFCAPPTAWRQFISLKNLNIELKHLKETVSAGEPLNGEVINKWKERYGTVIRDFYGQSESTAMVANLAGEEPVPGSMGKPLKSYNLVLVDDDMNLITHPLNIGNIAVGDYSGTYGLFLGYSDREKDASVFVNGYYLTGDKAYFDDNGYFYFISRTDDVIKTSDYRVGPFEVESAIIKNEAVLESAVIGIPDSMKYEKIKAFVILKDGYVKSEETAKSIHSTVKTLLPAYKCPRVIEFTDELPKTISGKIKRKELKQLELERANNGVKDNYTYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3A1</accession>
    <name>A0A1V0N3A1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoglutarate synthase subunit KorA</fullName>
            <ecNumber evidence="2">1.2.7.11</ecNumber>
            <ecNumber evidence="8">1.2.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-ketoglutarate oxidoreductase alpha chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate-ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_0712</name>
        <name evidence="16" type="ORF">HLB00_07235</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Berkeley</strain>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 oxidized [2Fe-2S]-[ferredoxin] + 2-oxoglutarate + CoA = succinyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17297"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="1.2.7.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-oxocarboxylate + 2 oxidized [2Fe-2S]-[ferredoxin] + CoA = an acyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotetramer of the KorA, KorB, KorC and KorD subunits.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="2"/>
    <dbReference type="EC" id="1.2.7.3" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000265">
        <property type="protein sequence ID" value="NOL60621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141834.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3A1"/>
    <dbReference type="STRING" id="74969.FAD_0712"/>
    <dbReference type="GeneID" id="31676214"/>
    <dbReference type="KEGG" id="fai:FAD_0712"/>
    <dbReference type="OrthoDB" id="31112at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000022">
        <property type="entry name" value="2-oxoglutarate ferredoxin oxidoreductase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000009">
        <property type="entry name" value="2-oxoglutarate ferredoxin oxidoreductase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053400">
        <property type="entry name" value="2-oxoacid_Fdx_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050722">
        <property type="entry name" value="Pyruvate:ferred/Flavod_OxRd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041170">
        <property type="entry name" value="Oxoac_fdxalpha_Archa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154:SF16">
        <property type="entry name" value="PYRUVATE FLAVODOXIN_FERREDOXIN OXIDOREDUCTASE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate/ketoisovalerate oxidoreductase catalytic" evidence="12">
        <location>
            <begin position="15"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding" evidence="13">
        <location>
            <begin position="247"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate:ferredoxin oxidoreductase core" evidence="14">
        <location>
            <begin position="517"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD84618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="NOL60621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="632" mass="70494" checksum="2575F16114FCED0C" modified="2017-06-07" version="1">MQETDINLLVGGPQGGGIDSAANMISMAFSLAGYNIYGIREFHSNIKGRHSYIHFRIKHERPKSLKYPVDIMVALDPDTLFEHMFDVAKGSRVVYDSAFNGFNLKNARMITSDTLGRIEEELSSRNLTYDVQGVLDYFKKTGIDVIAIPFDKLINENVHGGPANRYYNTLGAGTTLALLGLDIYHANDGIKFAFKKKPKVIESNINVIKAAYDYVENSSIKVETLPTYPAPPRMLLTGNDSTALGKLMGGLRFQTYYPITPASDESTLLESHEEMKFLETAGKDLKKAGLVVVQCEDELSAINMANGAALTGTRTATATSGPGFSLMAEGIGYAGMTEIPVVITFYQRGGPSTGLPTRNGQADLLFALNTGHGEFPKIVMSSGDMEECIYDGMKSLNYAQRYQMPVIHMIDKTLANTMDLVPEIDVKKVKIVKYNENTDHENFKRYSLNTEDGISPYGVFGKDIFWMTGDEHDELGHVTEDTKMRDRMMEKRMQKLITADNEIPLEDKVVLYGDKNADITYITWGSQKSLLLDAIDELKKQGVSANLLYLRMFEPFPAEYVEKVLKNSHLIIDVESNMTAQAAKVIRMNTGIKIENFILKYNGRHMTLDEILRSTKNIMEKKPALEVLQEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3B2</accession>
    <name>A0A1V0N3B2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3B2"/>
    <dbReference type="STRING" id="74969.FAD_0657"/>
    <dbReference type="KEGG" id="fai:FAD_0657"/>
    <dbReference type="OrthoDB" id="18209at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03257">
        <property type="entry name" value="ABC_NikE_OppD_transporters"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050319">
        <property type="entry name" value="ABC_transp_ATP-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43776:SF7">
        <property type="entry name" value="D,D-DIPEPTIDE TRANSPORT ATP-BINDING PROTEIN DDPF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43776">
        <property type="entry name" value="TRANSPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="313" mass="35193" checksum="9B8BA4F6AFE71822" modified="2017-06-07" version="1">MSNIITLNNIKKYYLTQEMQLLDVIFRRKPVYVKALDNVSIEIEKGKILGVVGESGSGKTTLGKLISTIEMPTEGEMFFEEDKITKKNLSLVRKHTSMVFQNPYTSVNPRMKIKSLVSEPLGKFDPEKVKEVLSLVGLDYDEIKNKEPKEMSGGQIQRIAIARALIKAPDLLILDEPTSALDESIQAQILDLLLDIQAQYNLTYLFITHNIGVAKYLTDKMAVTYAGKIFEYGDTKKIIESPKHPYTQLLIASVPDFEKKELASPVGDVPSLINVPPGCKFSNRCPKVMDICKKTEPEFRDVDGVKVLCWLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3D6</accession>
    <name>A0A1V0N3D6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0759</name>
        <name evidence="11" type="ORF">HLB00_06805</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GmhB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000242">
        <property type="protein sequence ID" value="NOL60540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141928.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3D6"/>
    <dbReference type="STRING" id="74969.FAD_0759"/>
    <dbReference type="GeneID" id="84217379"/>
    <dbReference type="KEGG" id="fai:FAD_0759"/>
    <dbReference type="OrthoDB" id="4991at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07503">
        <property type="entry name" value="HAD_HisB-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="D-GLYCERO-BETA-D-MANNO-HEPTOSE-1,7-BISPHOSPHATE 7-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891:SF1">
        <property type="entry name" value="D-GLYCERO-BETA-D-MANNO-HEPTOSE-1,7-BISPHOSPHATE 7-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004682">
        <property type="entry name" value="GmhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL60540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="152" mass="17440" checksum="5D041F97087534CD" modified="2017-06-07" version="1">MAGKRKAVFVDRDGTLNYDTGYTHKLSDLKIYDDIIPILKEYYDQNYIIIVVTNQSGIGREYYTVEDMEAFNNKLAEELMKYGVKIEEFFYCPHLPDQGCKCRKPGTGMIEEAAKKYNIDIKDSVVIGDRNSVDGTMARKLGIKFIKVHGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3G0</accession>
    <name>A0A1V0N3G0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-keto-3-deoxy gluconate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141808.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3G0"/>
    <dbReference type="STRING" id="74969.FAD_0700"/>
    <dbReference type="GeneID" id="31676202"/>
    <dbReference type="KEGG" id="fai:FAD_0700"/>
    <dbReference type="OrthoDB" id="350860at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00953">
        <property type="entry name" value="KDG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="290" mass="33041" checksum="3C15E44D3C7714E3" modified="2017-06-07" version="1">MQKLDSITPIITPFTDNKVDKDKAVRHGEDVLKGGMKYLFPAGTTGLGPSMASGEKHDLLDAFAHIPDHVILQVGSLNLEDSIYLAREAKKYKIHAVAALPPYYFTGMKREWLIKYYTKLSSEYPTIIYNYPDTTGYNITYDMVNDIKKAGGDVIGIKETTFNMNDILNTKMYVQDFKVYTGPDQYILSAYRLGLDGFVSGASNYGYKIINKIIENYDNKDGDRYQFLLNELADLSRKYGTISSIYDMVEIMTGIDAGNPREPFFKLSKEERNSLEKEMNEAFKKYNFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3H8</accession>
    <name>A0A1V0N3H8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141855.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3H8"/>
    <dbReference type="STRING" id="74969.FAD_0731"/>
    <dbReference type="GeneID" id="31676233"/>
    <dbReference type="KEGG" id="fai:FAD_0731"/>
    <dbReference type="OrthoDB" id="73420at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16272">
        <property type="entry name" value="RNaseZ_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="252" mass="28620" checksum="0547D5925B16A371" modified="2017-06-07" version="1">MEIKFLGNWSSHIQAGKRNVSMIIDGHILLDCGPHTIESMLESGIDPVQVDKILISHMHLDHYGGLAEILWYRAAREAKDEVIILGPKGIMKNTEQLLKIYNTPDHYMFSMKSNYVEINNNGEIYEVKTKFTDKVKNDYIEAFVGNHSIPDNMYRLEYHGNTIAYTGDTAYNDNIAQVGEKADIFLHEMTFTDQDAEIAKLSKHSTYSSVLRGFSESHAKKLVPVHLTDKTVSTLKAKSRENIILPFTDINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3K0</accession>
    <name>A0A1V0N3K0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141896.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3K0"/>
    <dbReference type="STRING" id="74969.FAD_0742"/>
    <dbReference type="GeneID" id="31676245"/>
    <dbReference type="KEGG" id="fai:FAD_0742"/>
    <dbReference type="OrthoDB" id="57548at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="386" mass="44715" checksum="3C94F2320A5A3356" modified="2017-06-07" version="1">MKLTFVTFTDLKVGRGTETVIFNLLKYKPEGIDATIVYTDDPGNNPLILSDKNVKDLIKNSKQIKIQKKSYKSKKFGKINRIYRDLIDKPAIRTLKSISKPVLEEIRDTDIAYLLYNEYAVFFNGMNIPVIGSNHTSGLELSVYEEQNTFFYRIYLKFLHQIYFKNINGYHVFPNKSQLLPMLNLKYNMVLAPGIDCSLYYPDYAVKNTKLKFLFVASLSSGKGLDILLPLIEKIDNSRAEFHIAGGGPMADEIKNNIKVIYHGILSNSELSKLYRECDVFIYPSHSDAFPAVTLQALSSGLYVMCSDYLKGNFDDFENKYLEYLPLDIEKWYSRVNEIIKNNNIIKHDKSEEYSYVKDNYDWPVISKKFYGYMMKFYNESKGINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3K6</accession>
    <name>A0A1V0N3K6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allantoate amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141914.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3K6"/>
    <dbReference type="STRING" id="74969.FAD_0752"/>
    <dbReference type="GeneID" id="31676255"/>
    <dbReference type="KEGG" id="fai:FAD_0752"/>
    <dbReference type="OrthoDB" id="35906at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006771">
        <property type="entry name" value="PRK09290.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="200"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="399" mass="44683" checksum="BEA5C40FAC5E8501" modified="2017-06-07" version="1">MVNEDFLTMFHRLTSVGWSEENGVNRLALNEYDIQARKNLEDEMKAVKADIKHDDAGLIFGTLGSGKDNTAIGSHMDSVPNGGRFDGFFGVMSGMQLLKDLVSTLKNRKITAIDFTNEEGARFQPSLLGSGMSTGVLTKEFTYSRKDSEGITFEEALKKSGYMGEEQNRVKNQDITRYLELHIEQGPVLELENYQIGIPKGIVTMVVDNVSFTGESNQAGPTPMKVRKDALVAASRFTVAVRDMAKSSGKELTMTVGKINNFPNAYNVIPGKVTMNLDTRSPDKKTAEEYSKMAKEISERIASEEGVPVDFKNQWTTETTIFDEDMRKEIIKSCKSLNLKYKELYSWPGHDAQYMNRVVPTAMIFIPSHNGRSHTKEEYSSDQDLINGYSVLKRTVENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3K9</accession>
    <name>A0A1V0N3K9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FeS cluster biogenesis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0777</name>
        <name evidence="2" type="ORF">HLB00_01905</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000049">
        <property type="protein sequence ID" value="NOL59589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887873.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3K9"/>
    <dbReference type="STRING" id="74969.FAD_0777"/>
    <dbReference type="GeneID" id="16025996"/>
    <dbReference type="KEGG" id="fai:FAD_0777"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="12251" checksum="75E287920003D679" modified="2017-06-07" version="1">MIDFNINSGKIQIQENLKDILSKKILVMRDNEETVSCDGGFCETIHDISIKVKRHCNEPKMYYFINDDIEIAMDEHIFDLLARENILIKKEKYLVVERVKHNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Q0</accession>
    <name>A0A1V0N3Q0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887909.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Q0"/>
    <dbReference type="GeneID" id="16026026"/>
    <dbReference type="KEGG" id="fai:FAD_0806"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="448" mass="52176" checksum="C19AD8F6F4C0CDA6" modified="2017-06-07" version="1">MATEHLEIKKIKGQNYAYSTVNLWDRENKKEIKISKYIGKVNGNNEIIRKVNLPDRSYQYGDVAFLVSMNYNLIKKISENYDKYWKEIITSALITIVGRIPLEYVKGYYRKTILYHYWPKLKLEPKNITSMLRYLAYNKLAFENLEEYDDSSLIMHVEIVIPVYAFNGKSRYARDNITLDIVFEPAQMRILNVEYFTGSEYMLSRFISRTEEAAKYDGVLILDSLHSTKKDINLLIRENKFFIVELSPDETKKFLDKVDPSGKTMLRRSFNSLLNRSIYYYRISMGNLHYFIMDDAYHGESESIKVSGNSSIMVALSNMDIDQGLVYQAINIKRFMYSSISSSKYRLDSDRKMISGKMELDGYVLFNIIAMKFYMSLYRNTIIPNPGRHKLVDSLMIELSTINMYLVKGELYLPRIGKSIMSDLNSVGGGIADKIFSKDLFSELNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3S6</accession>
    <name>A0A1V0N3S6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3S6"/>
    <dbReference type="STRING" id="74969.FAD_0906"/>
    <dbReference type="KEGG" id="fai:FAD_0906"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916:SF3">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="33"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="333" mass="38945" checksum="1795CF3F189FE387" modified="2017-06-07" version="1">MDVYIYTKFWAQSKYIFISKSYSSLMAGLPYISVIITAHSRRKYLLNAIKSAVNQTLDKEYYEIIVVKNFNDDLVDDFINKNHIKSIFMNGTIGEFLYSGVTNSLGQVISFLDDDDMFFDNKLEFIYKKFKGQNIAYYHNDHITINENGEPIRDNKIDNIIFNLSSISVMKNVINTENLIRITSNTDDFMYLSALESHKIALKGKERLTQYRFHHSTSVIITDDIKKFIQLKLEFLDTKLNQFKSFRNMFTSEETLSLIDSTITYLEMDMYIFGVKQKAGHIFRIFKNTPESFSQLFRLFTAYILVRLYSKSRNIILGQLWDAYKKSIENGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3U0</accession>
    <name>A0A1V0N3U0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Multi-ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142110.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3U0"/>
    <dbReference type="STRING" id="74969.FAD_0877"/>
    <dbReference type="GeneID" id="31676381"/>
    <dbReference type="KEGG" id="fai:FAD_0877"/>
    <dbReference type="OrthoDB" id="378722at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027802">
        <property type="entry name" value="Multi-ubiquitin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14452">
        <property type="entry name" value="Multi_ubiq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multi-ubiquitin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="82" mass="9357" checksum="AFB1853225A1D52F" modified="2017-06-07" version="1">MEREEKKFEIIVNGKPKPWQEITINYAQIVSLAFPQTTNPTDVFTVQYSHGTKEQSRGTMVEGQSVTIKSGMIFDVTRTFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3W1</accession>
    <name>A0A1V0N3W1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DedA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142114.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3W1"/>
    <dbReference type="STRING" id="74969.FAD_0881"/>
    <dbReference type="GeneID" id="31676385"/>
    <dbReference type="KEGG" id="fai:FAD_0881"/>
    <dbReference type="OrthoDB" id="10722at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051311">
        <property type="entry name" value="DedA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709">
        <property type="entry name" value="ALKALINE PHOSPHATASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709:SF10">
        <property type="entry name" value="SNARE ASSOCIATED GOLGI PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="2">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="211" mass="23079" checksum="AFB16CA894908794" modified="2017-06-07" version="1">MALLPYAFFSSLGYIGIFVLSLLSSLIIFIPVPYLFVILFAALSGRFDPGLLILSSTGGATIGKMALFQSFYSGAAITKTKTRENLTAFQTLVSRYAWIAVFIVASTPSPDDIVYVPLGIARYSRIHFFTALLAGKTVITALTVLGAGILSHSVFGSLILGEDKYSTIEIIIIGIIFAILAVLITYIINRIDWKKYIDKHASVKSRKQKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3W9</accession>
    <name>A0A1V0N3W9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin component PemK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142230.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3W9"/>
    <dbReference type="GeneID" id="31676456"/>
    <dbReference type="KEGG" id="fai:FAD_0955"/>
    <dbReference type="OrthoDB" id="90963at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50118">
        <property type="entry name" value="Cell growth inhibitor/plasmid maintenance toxic component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="104" mass="11538" checksum="1803E63B2175E330" modified="2017-06-07" version="1">MPESGDVILTRVKFADGSGSKIRPALVLFEEFGNVVIAGITTNLRMKGIYLSTSEGVPQDSVIKLNYIFTITNDAILKTVFHLSKEKRQLVLKGLREKLDTLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Y0</accession>
    <name>A0A1V0N3Y0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transposase IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0855</name>
        <name evidence="3" type="ORF">FAD_0920</name>
        <name evidence="4" type="ORF">FAD_1326</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142072.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Y0"/>
    <dbReference type="STRING" id="74969.FAD_0855"/>
    <dbReference type="GeneID" id="31676818"/>
    <dbReference type="KEGG" id="fai:FAD_0855"/>
    <dbReference type="KEGG" id="fai:FAD_0920"/>
    <dbReference type="KEGG" id="fai:FAD_1326"/>
    <dbReference type="OrthoDB" id="136106at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614:SF2">
        <property type="entry name" value="TRANSPOSASE IS4-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="182"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="453" mass="52785" checksum="99AE4A22E910013D" modified="2017-06-07" version="1">MTREIKKVGKYNYVYESSMVWDSEHSKRHKVSKYVGKVINGDIENPKKVREVVSIHGIYEIGHLELIFSLMKDVLSLLREEYPDDYTKIVAFSLNRLIFPLPLKSIKSWIEKTWLSRTIHELSPKSLSSMLKRIGQDQDKQKSIYMKLMKKNEVIAYDTSALFSYSPGIRMAEFGHNNNDINLPMIRIIMGFSRLRNEPCYIRLVPGSIADIDTLRKTEEELSPGTLFVMDRGFIDDNNFSKMDTNGLYFITPLKRDSKLPDYSINGDNFFMFRKRAIRYSSTTIKNYDIHVFEDILLRAMEENEYYSLVDSGKKPVYSPEKAGKIALITNVREKPQSIFELYKFRNDIEESFDVFKNLLQVDTPYLRDDDTLKGYVFVSFISLIAYYRLLKLLKAKKINNKISVKDALLQLSKIYLTDVGDRIIMAEIPKKVRELAEILELKPELFPKNVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N408</accession>
    <name>A0A1V0N408_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long chain fatty acid Co-A ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142318.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N408"/>
    <dbReference type="STRING" id="74969.FAD_1002"/>
    <dbReference type="GeneID" id="31676501"/>
    <dbReference type="KEGG" id="fai:FAD_1002"/>
    <dbReference type="OrthoDB" id="35688at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016877">
        <property type="term" value="F:ligase activity, forming carbon-sulfur bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05936">
        <property type="entry name" value="FC-FACS_FadD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF12">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE AND LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="476"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="563" mass="63424" checksum="B409292C01C16CF7" modified="2017-06-07" version="1">MIEVKVNSLDEALQKSYPPWVRRTIEIPDISIYRAFSDSVEKNKDNIAIDFMGKKITYSSLKEKIDSISVRLGELGITKGDRIAVMLPNIPQYITYFFAIVKLGAVIVQVNPLYTIRELEFEIKDSGANTLIVMDDFIDKALPLYPAKLKRILVVKVQYYLPPVVSQLYTLIKKEHKKIPVADNIYLCKVPKKSRFVSKEADIDPENDPALLQYTGGTTGMPKAAILTHKNLISNAYQIIEYMPEEYKKNISYLSSIPFFHVYGMMTAMLTPLLQGSKIILIPDPRDIKTALKIIDKKKPVAFPGIPTLYHGIITYKDVKKYHIDNVKICISGASPLPVELQKNFESMTGAILVEGYGLSECSPVANVTPLVEDEREKYRRFGSVGLPVSNTYEKIVSTEDGVTEMPLNEPGELLIKGPQVMKGYWNRPDENAKTLVDGWLHTGDIAKMDEDGYVYIVDREKDLIIAGGYNIYPREIEEVIYENPKVSECAVIGVKDAHRGETVKAFIVKKDSSLTDVEIINFCKERLAVYKVPKIIEFRDELPLTLVGKVDKKALRGGDNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N454</accession>
    <name>A0A1V0N454_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N454"/>
    <dbReference type="STRING" id="74969.FAD_1003"/>
    <dbReference type="KEGG" id="fai:FAD_1003"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="201" mass="23009" checksum="6E106F716145D292" modified="2017-06-07" version="1">MWAARNEKPRFRLFILKDPAFWYDAFIVTFVWVIWLAVIVKWGFSDIVRFTYDVFVAYIWYAYKVTLVPTAQGEVIVVDVVEFMYFVSTILEITTLLIVTLYSVTPLTLIVCISGLVKVILDALIEKSVKLIDFAVTVPDVTAAYETPETMLIAAKAIAIVINLFLLAWIFFVLSINLDIYITFYSKLLLVTYINMTAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4C1</accession>
    <name>A0A1V0N4C1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-ketoacyl-(Acyl-carrier-protein) reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1114</name>
        <name evidence="4" type="ORF">HLB00_00390</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000011">
        <property type="protein sequence ID" value="NOL59297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074111.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4C1"/>
    <dbReference type="STRING" id="74969.FAD_1114"/>
    <dbReference type="GeneID" id="16024344"/>
    <dbReference type="KEGG" id="fai:FAD_1114"/>
    <dbReference type="OrthoDB" id="24596at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="253" mass="27665" checksum="22DB1B0A3E307C31" modified="2017-06-07" version="1">MYDIKDKVCIVTGSGRGIGKAIAIKLAQAGGKIVVNVRTHEDEGMQTLEEVNKASSGILSMADVSTEEGRKKLFRDAIEKLGKPDILINNAGVGILEPFENIDEKHMQLMFNTNLYSPVWLSREFVSKYDNGVIINMASLAGISPFPGLSVYGMTKAALISMTKYLSLEAAGHHIRVNAVAPGVVKTRMGDSLLKIMNLDEKNFSKKFTLTGKLIDPDEVADTVLYLIRNESMTGQVITIDSGGEQMATDYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4E0</accession>
    <name>A0A1V0N4E0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142474.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4E0"/>
    <dbReference type="STRING" id="74969.FAD_1086"/>
    <dbReference type="GeneID" id="31676584"/>
    <dbReference type="KEGG" id="fai:FAD_1086"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
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</entry>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="NOL60433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="223" mass="25406" checksum="22E0887958C783F7" modified="2017-06-07" version="1">MEIKMPRLRKIFLLSFIIELVGFAVISSLPIHDPALYASFKSEDSAIISKSFFPMWLSIFPHNLLIASIEFIPVVGILMFGFSIGSTASVIAVEGTSTKVSGLAIFTSLMILPHSWLELPAYAVAASTSIYILYYLVKGQMGKKYMKIIYMYIFVVIELAFAGAIETSEIILEESAHPLYSLYMWIPAVPIIIFLIWLYRHMDSDEYKHKKEIEKDEYDFSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1V0N4M6_9ARCH</name>
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        <submittedName>
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    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:small molecule metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="152"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="362" mass="40131" checksum="9CA35FD7CA75B39C" modified="2017-06-07" version="1">MEGVMTLTTSAPGGGISYGRINMPDYKDGKAKIRPVYTGICGTDRAEIAGHLPFAYNPTGQNYMVIGHEAVCQVIDIGENNSRIRPGDYVIPIVRRRGTCINCRIGRQDNCSDADNDITEAGIRGADGFNSEYFFDSPENLIKVNDSSMAMLSTLTEPAKNVMKAFEIFDKLTKRSIFEAEDSTYISKNCLIIGTGSEAFLYAFMAREYDMTVYLTNRHRLLEEKMGIIEGIHGLFYNYLEENGPDKIDLLIDTSGDPAAVMKFVKKLNYNGIAILFGTNGAAPNSQLTGNDLNYIIEHNIAISGSVDGSKKHYMDAIGYLEKWRSSSGGIINKLITGIYKPEDTEIFRAKPPEEIKSIIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4N8</accession>
    <name>A0A1V0N4N8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142571.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4N8"/>
    <dbReference type="GeneID" id="84217787"/>
    <dbReference type="KEGG" id="fai:FAD_1192"/>
    <dbReference type="OrthoDB" id="385892at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="169" mass="19681" checksum="064E94ACD2CE2089" modified="2017-06-07" version="1">MKSIDNAWKVPLSRGGIFKIIINEDSLEIYRIFSGKYIEEKLHLKKDMDYIDSLIVPGATDPVEPEDLYNDIKNMIKTIFQHYNSNQSAKIQEIDNEKDSEEYRKIKFADIHDISMSASGDERFPELSLNGDRYILPSENFLAFSNADKERYEEYKNIVDGIRKQTGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4P8</accession>
    <name>A0A1V0N4P8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143168.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4P8"/>
    <dbReference type="GeneID" id="31676701"/>
    <dbReference type="KEGG" id="fai:FAD_1202"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03018">
        <property type="entry name" value="PRX_AhpE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050455">
        <property type="entry name" value="Tpx_Peroxidase_subfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43110">
        <property type="entry name" value="THIOL PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43110:SF1">
        <property type="entry name" value="THIOL PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="156" mass="17478" checksum="E1653E4E8E3A4479" modified="2017-06-07" version="1">MVEEGELAPDFEALDTGLKSKKLSDYKGNVTMLAFFPGAFTSVCTKEMCTFRDSMANFNKFNAKVVGISVDSPFSLKEFATKNNLQFDLLSDGNREISDKYGALYKSFLNINGLTASKRSVFVLDKTGKIVYKWVSEDAGKEPDYKKIEEVISKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4S7</accession>
    <name>A0A1V0N4S7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chorismate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142647.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4S7"/>
    <dbReference type="STRING" id="74969.FAD_1234"/>
    <dbReference type="GeneID" id="31676732"/>
    <dbReference type="KEGG" id="fai:FAD_1234"/>
    <dbReference type="OrthoDB" id="31228at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038764">
        <property type="entry name" value="GNAT_N_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41700">
        <property type="entry name" value="GCN5-RELATED N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41700:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="259" mass="30077" checksum="F7DC911A73AE39A1" modified="2017-06-07" version="1">MEVRRVENSSEIENFMEIIKSAWHSDSALSGFKDTIHSMAYHGGFVLGAWDEEKLIGMSFSYPGYKNNYTYLYSHMTGVIDQKKYSGVGYMMKMKQKELALDYGYRMIAWTFDPVMSLNGYFNIGKLGAVSRNYLDNFYGVMNDGINKGLPTDRLVAEWHIKENYNVQFNNPQFINQVDGYNMEFTEKPAGDVIGIKIIRDFYEFKKNDLNKAVQTKLMLRSKFHDVFSAGYVLINFDKVNNAYIFSKNYKLKEKNVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4T2</accession>
    <name>A0A1V0N4T2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkyl hydroperoxide reductase subunit c</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1228</name>
        <name evidence="8" type="ORF">HLB00_07045</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000254">
        <property type="protein sequence ID" value="NOL60583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142635.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4T2"/>
    <dbReference type="STRING" id="74969.FAD_1228"/>
    <dbReference type="GeneID" id="84217822"/>
    <dbReference type="KEGG" id="fai:FAD_1228"/>
    <dbReference type="OrthoDB" id="145578at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="195" mass="21918" checksum="69AC57A0CE9FAE27" modified="2017-06-07" version="1">MLQIGESAPEFETETYFPEKKEIKKIKLSDYRGKWVILTFYPGDFTFVCATDIEALMGSYDKFLKEGAQVFGISEDSVFSHKAWCDTSPRVSKSKIPLIDDYTKEIAKNYGFLDAKGYQAQRGLVIVDPEGKIQYEAMFNDGLGKDVRHIYGAFMGLKVLHDTPEGEGHMCAIPADWTPGESPLDINVVRDIGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4X4</accession>
    <name>A0A1V0N4X4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Medium-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1271</name>
        <name evidence="4" type="ORF">HLB00_03220</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000103">
        <property type="protein sequence ID" value="NOL59844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142731.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4X4"/>
    <dbReference type="STRING" id="74969.FAD_1271"/>
    <dbReference type="GeneID" id="84217866"/>
    <dbReference type="KEGG" id="fai:FAD_1271"/>
    <dbReference type="OrthoDB" id="35688at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016877">
        <property type="term" value="F:ligase activity, forming carbon-sulfur bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF11">
        <property type="entry name" value="MEDIUM-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="415"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="503" mass="56217" checksum="EDAD7A7A7073F78E" modified="2017-06-07" version="1">MGNGFTVINIMKRASSLFPEKKVISGSRSITYRDLFEKVLRLSTSMNKMGISKGTVIAVADYNSIEFMELLFASSLTGSIIYPVNIKLPWNMAMETVKESGAEYVFASKEFMNAGIYKGFRDDHIVSLSENGDYIKFHDLLTSDLHREEKTTGNDNYSILFTSGTTGKPKEVLYTNEKSVNGALSILYQLGLFNTPAKLTSSDTILSLIPFYHIWSWGSAFHAAYLGADYIITGKYNPENVLDAIKENKATWINAVPTMVYDLLSHDRENRLDGIKMLIGGSPISKNLAEKLNANGIKFSTIYGGTDMLATSISLGRPDQHESLRSVTYPVPMVSATVRDNTGNILENGTIGELWINAPWLPEKYLNRPENHDYENGWFKTGDVGEMTPDGGIKILDRVKDVVKSGGEWIPTSIIESLISEFPGIEIVAVTAIADEKWGERPIAWVKASEDIEIEEIRQFMETHASNGNINKWWIPVEFIIIEEMPMTSVGKIDKAKLREMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N518</accession>
    <name>A0A1V0N518_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142860.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N518"/>
    <dbReference type="STRING" id="74969.FAD_1370"/>
    <dbReference type="GeneID" id="31676862"/>
    <dbReference type="KEGG" id="fai:FAD_1370"/>
    <dbReference type="OrthoDB" id="19248at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10359">
        <property type="entry name" value="A/G-SPECIFIC ADENINE GLYCOSYLASE/ENDONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10359:SF19">
        <property type="entry name" value="DNA REPAIR GLYCOSYLASE MJ1434-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001435">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="33"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="210" mass="24680" checksum="9AFEAE3025321D38" modified="2017-06-07" version="1">MFGDLYNLLYVYYGNLEWWPSETDDETVIGTILTQNTSWKNVEKALKKMKENHVYTLNEIATTDQERLKELIKSSGFYNQKSRYLLTLSKEITEKYGNLPGMKNKDIKEIEGFIMGLNGVGNETMESIMLYALDYPVFVVDAYTLRFFKRFYGKDFSRKEIRNYAEEEFSEIDQLKNFHGMIVNLGKDFCKKTPVCKSCFLRDDCLYGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N522</accession>
    <name>A0A1V0N522_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
            <ecNumber evidence="4">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">5'-deoxyribose-phosphate lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">AP lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">polX</name>
        <name evidence="25" type="ORF">FAD_1333</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76255"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:18657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:195194"/>
            <dbReference type="ChEBI" id="CHEBI:195195"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
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        <property type="entry name" value="HHH_MUS81"/>
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        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
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        <property type="entry name" value="NT_sf"/>
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    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
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    <dbReference type="InterPro" id="IPR022311">
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        <property type="entry name" value="PolX_PHP"/>
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        <property type="entry name" value="RuvA_2-like"/>
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        <property type="entry name" value="PRK08609.1"/>
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    </dbReference>
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        <property type="entry name" value="DNAPOLXBETA"/>
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    <keyword evidence="10" id="KW-0235">DNA replication</keyword>
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    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="25" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="25" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="25" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="25" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
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        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
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        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
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        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
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    <feature type="domain" description="Polymerase/histidinol phosphatase N-terminal" evidence="23">
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            <begin position="341"/>
            <end position="419"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022481"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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        </source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045548"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
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    </evidence>
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    </evidence>
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            <dbReference type="SMART" id="SM00481"/>
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        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ARD85196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="572" mass="65016" checksum="5762B8A7E893C766" modified="2017-06-07" version="1">MSNSEIAGIFENLYNILSIDEKTKFEALAYQRVARELQSMPDDVSDLYDKYGIGGLMKIPGVGKGIAQHIIEYLKTGKIEKYEKIKSEYPIDFKDLFRIEGLGPKKAILLYKKLGIKNLNDLKKAAEEHKIADIPGFGKKSEELILKNISMLASLHGRILLAQGLNEARKIISYLTKSDFIDRCFIAGSTRRMKETLGDIDILATSKDSKKTMDLFINFEDARSVMIKGETKTTILLSTGVTCDLRVINDASFGAALQYFTGSKDHNIKIRKIAIGNNYKLNEYGLFYNDSNIAASKDEKFIYNRLNMDYIPPEMREDRGEIELALQHRIPELISLNDIKGDLHLHTKESDGLNTTEEMVNAALEKRYEYIAMTNHTKNLKIAHGIGDQDFIKYFDTVDKLNQKYKIKILKGAEVDILKDGSLDLKDETLGQMDCVIASVHMNISMEKEDMTQRVINAIKTGKVNILGHPTGRLINKRSSYEIELDEVSKYCEKYKTALEINSSPERLDLNDENILKTSKYNVYYSINTDSHNIYGYDFMELGVGTARRGWLGKEKVINTMDLNGLMKFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N526</accession>
    <name>A0A1V0N526_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DedA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
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    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051311">
        <property type="entry name" value="DedA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709">
        <property type="entry name" value="ALKALINE PHOSPHATASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709:SF6">
        <property type="entry name" value="UNDECAPRENYL PHOSPHATE TRANSPORTER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="40"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="220" mass="25124" checksum="35A91283F58D4176" modified="2017-06-07" version="1">MSIITSITVGLIKFVEVIIIKLGLGGVFFLMLLEGMLLPIPSEIVMTFSGYLAFYRLLDPYSPYVSVVLLLIVGSVGDLIGAWIAYWIGKYGGDPFIIRYGKYLFLKPDTIDRTKAWFNRYGELSVFITRFIPVFRTFISIPAGIATMNFRKFSIYTLSGDVIFNVVLIYLGILFGSHWEILLKYFDEYSYVGIAIFAVIIIYLIVRIIRNRNESTQLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N570</accession>
    <name>A0A1V0N570_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydropyrimidinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142874.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N570"/>
    <dbReference type="STRING" id="74969.FAD_1397"/>
    <dbReference type="GeneID" id="31676889"/>
    <dbReference type="KEGG" id="fai:FAD_1397"/>
    <dbReference type="OrthoDB" id="24954at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016812">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="6">
        <location>
            <begin position="52"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="457" mass="49659" checksum="A44E6DDFED4F7EBF" modified="2017-06-07" version="1">MSFDLILDDGNVFLHGGLKRTSIGIINGKIAVIGNLNDFKGNTKRINLSGKLVIPGGVDPHTHIEGYSSAGTIKNGTESAAIGGTTTVLDFSQATKNEDTVAAAASKIKRFSDSSSLDFTIKPMMVTEDFQSIERLELIFSQLSKLGIMAVKIFTTYKNLGRYANNYQILQGMNTAKKYGIMVQIHAENNDFLEGNMEALLAQGKTDPKYHAISKPPVSEDVAVADSAVMAGDSGAKVYCVHLSTKTSPEIIDSARKHGVNIYGETCPQYLILDDSFLDREDGNLYLCSPPLRKKEDINAMWNAISSGKIQAVGSDHVPFLAYQKKKGIPFNKVPNGIPGIETRLPLLFSEGVQKGRITLEKFVDVISTSPAKIFNLYPQKGTISIGSDADLTVIDTELEHRLRAEDLHMGTDIAIYSHMKTKGWPVLTISGGEIVAENDVFTGKGKKGHFLGKEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N571</accession>
    <name>A0A1V0N571_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="6">FGAM synthase</shortName>
            <ecNumber evidence="6">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="6">FGAR amidotransferase III</shortName>
            <shortName evidence="6">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">purS</name>
        <name evidence="7" type="ORF">FAD_1430</name>
        <name evidence="8" type="ORF">HLB00_03765</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PurS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000121">
        <property type="protein sequence ID" value="NOL59949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886537.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N571"/>
    <dbReference type="STRING" id="74969.FAD_1430"/>
    <dbReference type="GeneID" id="16024662"/>
    <dbReference type="GeneID" id="84218023"/>
    <dbReference type="KEGG" id="fai:FAD_1430"/>
    <dbReference type="OrthoDB" id="56303at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase subunit PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00302">
        <property type="entry name" value="phosphoribosylformylglycinamidine synthase subunit PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="80" mass="9440" checksum="FB52E447E76CCFA4" modified="2017-06-07" version="1">MKVKVQIKYLPNVEDPEALSIKRNLELIGYEGIKNIYSYKIYEFETSLDREDSISEIREIAEKLLTNPVIQEYKIEDISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N573</accession>
    <name>A0A1V0N573_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histidinol-phosphate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886495.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N573"/>
    <dbReference type="STRING" id="74969.FAD_1384"/>
    <dbReference type="GeneID" id="16024621"/>
    <dbReference type="GeneID" id="31676876"/>
    <dbReference type="KEGG" id="fai:FAD_1384"/>
    <dbReference type="OrthoDB" id="9929at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="4"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="316" mass="36051" checksum="BFD9147D6DF0F2B0" modified="2017-06-07" version="1">MEEIYLDKNENPFNVPEKVKKEFINYAKDADFNRYPEKGLPSLIKKLAGLTGFSSENIIAANGSDELLDILIRRAEGDIVVSSPTFEMYSFYARNYGHKAIDVPLRSDFSLDVNGILAQKDAKLVVICSPNNPTGNLIDRESIKKILDSGVTTILDNAYYEFSGEDYTDLIAKYSNLIILRTFSKAFSLAGMRIGYGIAESKFISEIKKLQAPFYMNILSAKMAEIMIDNYSLIVEKIKYIVEERERVYNEIKDIAYPSSANFLLLKKDLYGYMEENGIHIRKLPLVKDRSRLTIGTKDENKRAIEAIKKYVMEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N585</accession>
    <name>A0A1V0N585_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF998 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142876.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N585"/>
    <dbReference type="STRING" id="74969.FAD_1399"/>
    <dbReference type="GeneID" id="31676891"/>
    <dbReference type="KEGG" id="fai:FAD_1399"/>
    <dbReference type="OrthoDB" id="103507at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42241">
        <property type="entry name" value="HYPOTHETICAL MEMBRANE PROTEIN, CONSERVED, DUF998 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42241:SF2">
        <property type="entry name" value="HYPOTHETICAL MEMBRANE PROTEIN, CONSERVED, DUF998 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21871" checksum="B695D9A0F7FC0243" modified="2017-06-07" version="1">MKYIKYLGFSAIAAAWITIFAAISVNPWFRIQKNALSDLGGTNTISNFFQHQAPADPYIYNVGLMVTGLLIALFAIAAIANSRNSIENTGSAFFIIAGLFLALIGIYHEGTYPHDFVSIWFFIIASIAYATIGISLLFTKFRKVGIAILIILPVSWVLFIEIPWQSVAEDEIFGVIVIDIMVLLHIYTFQKLKNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5E8</accession>
    <name>A0A1V0N5E8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19 20">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="5 19 20">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">cobS</name>
        <name evidence="21" type="ORF">FAD_1479</name>
        <name evidence="22" type="ORF">HLB00_03085</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Berkeley</strain>
            <strain evidence="23">Y</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 24">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>alpha-ribazole + adenosylcob(III)inamide-GDP = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>alpha-ribazole 5'-phosphate + adenosylcob(III)inamide-GDP = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Cell membrane</location>
            <topology evidence="2 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="5 19 20"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000098">
        <property type="protein sequence ID" value="NOL59818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886585.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5E8"/>
    <dbReference type="STRING" id="74969.FAD_1479"/>
    <dbReference type="GeneID" id="16024710"/>
    <dbReference type="GeneID" id="31676972"/>
    <dbReference type="KEGG" id="fai:FAD_1479"/>
    <dbReference type="OrthoDB" id="11748at2157"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="ADENOSYLCOBINAMIDE-GDP RIBAZOLETRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148:SF1">
        <property type="entry name" value="ADENOSYLCOBINAMIDE-GDP RIBAZOLETRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="NCBIfam" id="TIGR00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ARD85337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="NOL59818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="248" mass="27461" checksum="CC23759A0E898C48" modified="2017-06-07" version="1">MNKYVEGLISAISFFTIIPLGGNYKITGYTMYFFTFTGLIVGLIAGIPYLVLRPYNSLIASTVSVAIIILLYGFNHLDSIMDFGDSIMVRGKEEKQRVIKDRYTGSGGIGMLFIIYIPAIAFLTYFKPVTGFFIIIAGEMASKYATLFSMYRAKAFGEGLGKMFIDKVSANAIVLNVIPLLLAFAFNLYNIAIIAALIFLSYFMRSAMEKHYGGLNGDLAGSIGEISRLLFYAITFVFIALKLNLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5H4</accession>
    <name>A0A1V0N5H4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispB</name>
        <name evidence="7" type="ORF">FAD_1515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886654.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5H4"/>
    <dbReference type="STRING" id="74969.FAD_1515"/>
    <dbReference type="GeneID" id="16024781"/>
    <dbReference type="KEGG" id="fai:FAD_1515"/>
    <dbReference type="OrthoDB" id="26738at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="330" mass="37058" checksum="8ADE865803D8C612" modified="2017-06-07" version="1">MKNFYEWQYGLRDKINEVNSRLLQAIKTDQPYLFEMSKYTIDAGGKRFRPLLTILSYEISCNEPYDSILDLASGYELIHTASLIHDDIIDKSKYRRGRETLASRYGIDNAIVVGDYLFAKAYELGSRYGKVVSKVMADGSSHLAEGQIIEALNIGNLSLDIETYNKIIMNKTAYFFSACAEGATIAAMAPDNVRDKLSKFAYNMGMAFQITDDILDIVGNEKEMGKPTMVDLNHDVITLPIIHALSHVTGENKRTLVNILTGKYTDSDYKSKFRDILFKSGSLEYTFKIAKDYILKSVENLNGIGRSDDLGLLMDLALIVVDRINESGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5K9</accession>
    <name>A0A1V0N5K9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1517</name>
        <name evidence="6" type="ORF">HLB00_09465</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000417">
        <property type="protein sequence ID" value="NOL61046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886656.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5K9"/>
    <dbReference type="STRING" id="74969.FAD_1517"/>
    <dbReference type="GeneID" id="16024783"/>
    <dbReference type="KEGG" id="fai:FAD_1517"/>
    <dbReference type="OrthoDB" id="14434at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050684">
        <property type="entry name" value="HTH-Siroheme_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43413:SF4">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43413">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, ASNC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL61046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="129" mass="14805" checksum="83899856CED6932E" modified="2017-06-07" version="1">MDETDYKIIDFLREDSRETNMEIARKLNVSEGTIRKRIMNLVNSGIIRKFTIETSLSIEGIVLIELDSRQASNTLKTLKSLYSDIYEFSGSIDVAVRISKNTIEELNMEVDKIRDLKGVVNTDTMVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5M1</accession>
    <name>A0A1V0N5M1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142957.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5M1"/>
    <dbReference type="GeneID" id="84218164"/>
    <dbReference type="KEGG" id="fai:FAD_1570"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="283" mass="30251" checksum="F50817060EE65265" modified="2017-06-07" version="1">MITVNRKSLLIVATVITAALMIGMPLSAAASPGNTPAYLASGSSMNYICSTSGYAYSQEYSHSNGIGKTTISNSTTGPATYYYNVSVSSSNNTVANITVPTSNGMSSYTNVPISDAKYMVPTYVSNSSKSVTVLIPMSGGNFNGLYGNYNYTVNYSKTINFSYYKTAFGTVKATEYVISEHEIVNQATPSTAASYKNITGTIYINSATNVILGLNINVYDMHVKSGTTPLNETYTSTGYTYTIDLSSTNVVPVHTELTGAYIGIGVAIVLLGITLYYFYGRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5N4</accession>
    <name>A0A1V0N5N4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886746.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5N4"/>
    <dbReference type="STRING" id="74969.FAD_1614"/>
    <dbReference type="GeneID" id="16024880"/>
    <dbReference type="KEGG" id="fai:FAD_1614"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Pre-PUA domain, domain 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CHP03684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015266">
        <property type="entry name" value="DUF1947"/>
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    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
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        <property type="entry name" value="PUA_sf"/>
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        <property type="entry name" value="Uncharacterised_CHP00451"/>
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    </dbReference>
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        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09183">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
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    <dbReference type="PROSITE" id="PS50890">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="68"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="149" mass="16795" checksum="F2EF420BF093EB5D" modified="2017-06-07" version="1">MSKHILSKKDYRAFMEKLSAFNIDGTSMADIEVETNKKNEVYYFSGKPVFYNGMPTLYLINYLKIKTHNVTVDNGAVPHLMNGSNLFAPGIVDMDPNIKKGDMVFIKNMEGLYIAIGRANDSGDAIMSSRKGEAVEILHYLNDKVMKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5P9</accession>
    <name>A0A1V0N5P9_9ARCH</name>
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        <submittedName>
            <fullName evidence="5 6">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1561</name>
        <name evidence="6" type="ORF">HLB00_00985</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886703.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5P9"/>
    <dbReference type="STRING" id="74969.FAD_1561"/>
    <dbReference type="GeneID" id="16024832"/>
    <dbReference type="GeneID" id="31677052"/>
    <dbReference type="KEGG" id="fai:FAD_1561"/>
    <dbReference type="OrthoDB" id="372125at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="60"/>
            <end position="284"/>
        </location>
    </feature>
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        <location>
            <begin position="284"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="360" mass="40758" checksum="EF3DB6C205B14515" modified="2017-06-07" version="1">MTIQERIKEIEDEIKKTQKNKATEKHIGLLKARMSKLELEEESHKKSGGYGFSVSKSGDATMALVGYPNVGKSSLLNALTNKKSTVGNFEFTTLTVIPGTLNYNGAQIQILDLPGIIDNAALGAGRGREIISTIRNVDLIVLVTDIQLKGLDRIIAELYKAGIVLNRKKKNIAFKRTNYGGLRIHKPRNVDIDNGDIRDIAKEFKIVNGDIYIRENIDMDDLIDFFKGNIVYIKSFMVVNKIDMPHDEEQLKRKLKDFGNYIEVSAETGHNLESMKNMIYKTLDMVRVYMRNKSGEVDYERPLILSEGATIRDVSRKISREMISTFRYAIITGPTRKIEARVGLDYKVNDEDVVTLISKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Q9</accession>
    <name>A0A1V0N5Q9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Q9"/>
    <dbReference type="KEGG" id="fai:FAD_1572"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="137" mass="15686" checksum="00C34F4CECD059CC" modified="2017-06-07" version="1">MVNLYGLIMGFIYLIIFYIISWRMLVYILFLIYRKYIPESSTKKSILFSTVITFSILILLYYPLYGIYLLATKDVFPLGIAGLIIVYLNISVIIGFAPLSIIYTTRDNYKAALKIGGLTSVVLFLYMNLSAFIFLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5T1</accession>
    <name>A0A1V0N5T1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps10</name>
        <name evidence="7" type="ORF">FAD_1648</name>
        <name evidence="8" type="ORF">HLB00_04405</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000151">
        <property type="protein sequence ID" value="NOL60076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886783.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5T1"/>
    <dbReference type="STRING" id="74969.FAD_1648"/>
    <dbReference type="GeneID" id="16024917"/>
    <dbReference type="KEGG" id="fai:FAD_1648"/>
    <dbReference type="OrthoDB" id="371736at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000004">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="103" mass="11729" checksum="B6386D5E0D8E9982" modified="2017-06-07" version="1">MAYKARISLSGTENQIVDVVCNEIKAIAKRTGVEIHGPIPLPTKKLKVPLRKSPDGEGSPTWDRWEMRVHKRLMDVDADERTLRQLMRISIPDGVRIEIQIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5U0</accession>
    <name>A0A1V0N5U0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5U0"/>
    <dbReference type="KEGG" id="fai:FAD_1637"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="60" mass="6888" checksum="32F5D76A0F2A4B52" modified="2017-06-07" version="1">MNYATHYSIKPTTPRTPKIHFNLDRAYHLLLSIALEIEHCQLVQFESPTITSIAAMFPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5V4</accession>
    <name>A0A1V0N5V4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
            <shortName evidence="1">HPPK</shortName>
            <ecNumber evidence="1">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">6-hydroxymethyl-7,8-dihydropterin diphosphokinase</fullName>
            <shortName evidence="1">6-HMPDK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydro-6-hydroxymethylpterin diphosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
            <shortName evidence="1">PPPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mptE</name>
        <name evidence="3" type="ORF">FAD_1622</name>
        <name evidence="4" type="ORF">HLB00_02480</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal 6-HMPDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="1"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000075">
        <property type="protein sequence ID" value="NOL59700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886753.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5V4"/>
    <dbReference type="STRING" id="74969.FAD_1622"/>
    <dbReference type="GeneID" id="16024887"/>
    <dbReference type="GeneID" id="31677111"/>
    <dbReference type="KEGG" id="fai:FAD_1622"/>
    <dbReference type="OrthoDB" id="34207at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02131">
        <property type="entry name" value="HMPDK_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648:SF1">
        <property type="entry name" value="6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MptE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-hydroxymethylpterin diphosphokinase MptE-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="224" mass="25294" checksum="E7CB99D2B76EE055" modified="2017-06-07" version="1">MNFDQWFQLYLQITDSLGINRKMDYESSMILRKFIHNSDNILDAYRGRNAFIIGNGPNLKNAIKTISGGYVIVADSAIETYSSLYGNPDIIVTDLDGNINSIIDSYNRGSIILVHAHGDNINAIEKYAKYFSNGIATTQYIPMAHLYNYGGFSDGDRSAFLADYLGARHITLLGFDFKNVNIKPYYDNTAIIRKKIKLEWAKYLLGCLSKLRGTSMHYGDVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5V6</accession>
    <name>A0A1V0N5V6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1668</name>
        <name evidence="3" type="ORF">HLB00_00440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000012">
        <property type="protein sequence ID" value="NOL59307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886809.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5V6"/>
    <dbReference type="STRING" id="74969.FAD_1668"/>
    <dbReference type="GeneID" id="16024940"/>
    <dbReference type="GeneID" id="31677159"/>
    <dbReference type="KEGG" id="fai:FAD_1668"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="253" mass="29981" checksum="420EA862CC195567" modified="2017-06-07" version="1">MRIKNNLMSIIFQDFDSRYFIEIILIIGICATVYFSYIQSISISPHLNFGYPEIGVLFFFKQYLYYASYPLFTIFYIVTIVISSYEVFLFSSSIVRNKFLVMYSMGFRKNSIILSYFILFVIYPLLILSISYFVISYVDFFSIEYYIIWHLVLFTFISLMFFISIGMVLSAITKNLLIPGAFIIIFFYFLVPLVYIRPQNTILYHVVDPVYGYLNYGFNHITFIGVIIEVLLSLMFIFLTMLIARYRDMKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5X5</accession>
    <name>A0A1V0N5X5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OsmC family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">OsmC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1642</name>
        <name evidence="2" type="ORF">HLB00_07215</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000264">
        <property type="protein sequence ID" value="NOL60617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142991.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5X5"/>
    <dbReference type="STRING" id="74969.FAD_1642"/>
    <dbReference type="GeneID" id="84218234"/>
    <dbReference type="KEGG" id="fai:FAD_1642"/>
    <dbReference type="OrthoDB" id="84927at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34352">
        <property type="entry name" value="PROTEIN YHFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34352:SF1">
        <property type="entry name" value="PROTEIN YHFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="138" mass="15630" checksum="541FCC49AD3EAD3B" modified="2017-06-07" version="1">MKVSFKFDSDVGFISDDGKRETKFKNSIVGNDEYHSPTELLLLAMGGCSSDDVLNILKKMKKEIKSYRCEVTGEKRDTDPKLLKYGEIHYIFEGDMDPESVKKAIDLSLEKYCSVSLTVKGAGIPVSYYYTINGQDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Z8</accession>
    <name>A0A1V0N5Z8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PD-(D/E)XK endonuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143005.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Z8"/>
    <dbReference type="STRING" id="74969.FAD_1662"/>
    <dbReference type="GeneID" id="31677151"/>
    <dbReference type="KEGG" id="fai:FAD_1662"/>
    <dbReference type="OrthoDB" id="57351at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="53348" checksum="EAA5CB2D0E5C7E09" modified="2017-06-07" version="1">MSFLREVKYSILSDTENTYISRVLEDRIKIKNFDIPEYLYVTDLINPVRSYFTRKYPEIPLPENVEARMKNGEEIHFLARQWFEQLPGFSGSEVILTGADIGLNVVGRADFMLYNSIVEFKTKHVDMIDLESIYSVYSSDLEQLLFYAAMNKNFTEDNYLVFFSDEKFYVYKVSVHDRAIIEDEMVYRFSLITRAMENGDIGDFPRCSYFGYGCQFSEAQVCPCHSLRHSDSSWISNVAKVEEDYGMESRLQEIYEHGKSTIDLRFYDLIYQRKYYHKITGDSRNAGSSGQIPDSYYEKNNIKFFVLGSIDSSILNVSGTEKANINKVSTLPLYGDDRYIIKNIYDENTIVPYLLKINNSKYTNNIPDTYYSELAITCARRNIKEGLIVVVYPKLEKTIKVHEVKFDIDRIISACRTSIENIETAVARKTPEILDMCPEFAIKSCDFASCSCRREIIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N602</accession>
    <name>A0A1V0N602_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143036.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N602"/>
    <dbReference type="STRING" id="74969.FAD_1701"/>
    <dbReference type="GeneID" id="84218321"/>
    <dbReference type="KEGG" id="fai:FAD_1701"/>
    <dbReference type="OrthoDB" id="6995at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF53">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR LRPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="140" mass="15770" checksum="4219F35CA49DC282" modified="2017-06-07" version="1">MVDKLDTEIARYLIDNSKLSIRDLAKLCNVSPGTIRNHLQKMETDKQIIAYTTRLQGKRLGLEEAILGLDIMPEHYTRTLEELRKLTFIKSLFSTSGDHSAIAIVISKLYGKSMNECIAEIEATEGVRNVYPSIVNSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N608</accession>
    <name>A0A1V0N608_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Transposase IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0707</name>
        <name evidence="3" type="ORF">FAD_0926</name>
        <name evidence="4" type="ORF">FAD_1673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141818.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N608"/>
    <dbReference type="STRING" id="74969.FAD_0707"/>
    <dbReference type="GeneID" id="31677164"/>
    <dbReference type="KEGG" id="fai:FAD_0707"/>
    <dbReference type="KEGG" id="fai:FAD_0926"/>
    <dbReference type="KEGG" id="fai:FAD_1673"/>
    <dbReference type="OrthoDB" id="136106at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614:SF2">
        <property type="entry name" value="TRANSPOSASE IS4-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="167"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="458" mass="53023" checksum="2157760F374E613A" modified="2017-06-07" version="1">MNNMPDWVLKHKGKGIEIRRFGDRYYAYESSSRYDKDLKRAKKVTGKYLGVVTPAGIIKKSDVSGISGDYEYGNIALLYGIAGKTILPVLKQVFPYMYERIIIYVILRDIQPLPMKSLRYLYEKTYLSRMYNESMSPGSISGMLSSLPQEGMVAVMRKLTEKGEYVLMDSTAIFSRSENISFLEPGHNSKEIHLPQINVMMLFSSTRTVPTFIRILPGSIRDVSAMANTIDIAGVERCVIVADKGFFSADNIKKLKRRHLSYIIPLRRNSSIIPESGDFLNVFMYNGKPVKYWKPENGVYVFEDPVLKSEEERDYLIRIHDNIRSKSSYYDHSGDFGKLYLLSDIIDEPERIYRLYKEREYVEYAFNVYKNDLEADRSYIRDDHMLSSYMFLNLLSLYLHFQVLNTIDGKYSVRDILLILSRIKIYSTGKTEMVSEIPKKAKELISKLGVDLDILRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N618</accession>
    <name>A0A1V0N618_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="3">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Phosphoriboisomerase A</fullName>
            <shortName evidence="3">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rpiA</name>
        <name evidence="4" type="ORF">FAD_1733</name>
        <name evidence="5" type="ORF">HLB00_00220</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000007">
        <property type="protein sequence ID" value="NOL59263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143065.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N618"/>
    <dbReference type="STRING" id="74969.FAD_1733"/>
    <dbReference type="GeneID" id="84218354"/>
    <dbReference type="KEGG" id="fai:FAD_1733"/>
    <dbReference type="OrthoDB" id="19013at2157"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000001">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="27"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="222" mass="24425" checksum="439969B54461AD77" modified="2017-06-07" version="1">MYENEKKVSAMEALKHVHSNMKLGLGTGSTTKYFLDGLGELVKSGKITGITGVPTSLRTADLAKSYGIKIENNLEGIEIDFDGADEFDGSGNLIKGGGGALVREKIVAYNSKEVYIMADHSKFSEKLHSFPLPVEVLPFMEDVTKKNIEKTGCKATFRDGKNFKSDNGNYILDCRFDFTDVALEKKIKMIPGVVEVGIFSGITTKVFIGENEKCRVMDFQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N623</accession>
    <name>A0A1V0N623_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1761</name>
        <name evidence="6" type="ORF">HLB00_08590</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000320">
        <property type="protein sequence ID" value="NOL60880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143074.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N623"/>
    <dbReference type="STRING" id="74969.FAD_1761"/>
    <dbReference type="GeneID" id="84218384"/>
    <dbReference type="KEGG" id="fai:FAD_1761"/>
    <dbReference type="OrthoDB" id="4665at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="177" mass="20443" checksum="98414E20AE6FE386" modified="2017-06-07" version="1">MFTRRGDQGETDNGLRVRIGKDSPMVDFQGTLDELNSFIGNALINTKWDDIRNDLIKIQNDVFVLGEDLTAESQHRTIKEEDVKWLEQRATEYRKEIGKIKLFVIPDGSQEAVSLHIARTVARRAERLSVFVSKEMSVNKYILIYLNRLSSVLFMQALASNKRLGITERIWDIKRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N626</accession>
    <name>A0A1V0N626_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143034.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N626"/>
    <dbReference type="GeneID" id="31677190"/>
    <dbReference type="KEGG" id="fai:FAD_1699"/>
    <dbReference type="OrthoDB" id="381119at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="174" mass="19886" checksum="68ABCD24296392F4" modified="2017-06-07" version="1">MVNEDKLKSDIEKCRKVSQDGSMVTYDLTSGVDFSNPKLVAKELAEVFFEKDAKNWFKVDDDKIDFEPTYKVRVVLAEENNRKLEATVDDLLEDIKKDDISGTYSKQIKDDSVVDSHLQSTIAASAIRSAIFRHSEEKVYAGSISDDLFTDILEKLEIRSLNDKDLMDWKKLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N628</accession>
    <name>A0A1V0N628_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1744</name>
        <name evidence="2" type="ORF">HLB00_03910</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000127">
        <property type="protein sequence ID" value="NOL59978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886886.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N628"/>
    <dbReference type="STRING" id="74969.FAD_1744"/>
    <dbReference type="GeneID" id="16025019"/>
    <dbReference type="GeneID" id="31677235"/>
    <dbReference type="KEGG" id="fai:FAD_1744"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="214" mass="24895" checksum="FDD6E85B44E70A23" modified="2017-06-07" version="1">MPDELPVIWFKSNKDPQASFAASLWITMHTQIYKYTHANNYIMRINNINSILSFNEYFGFLADNTTLSGISAILNRNLRKMKIKEFYFSLSEDNDIGKAINYMEKGRPVVMGFPYKFIGPLVKYEVINNNLPENIMYYFTAFIYRDKILLIPGFEGVELKTGINDFYKRTGDKVKAMEIDEFTGYCEKLGSRIKIVYANVLARNGEELRSLNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N643</accession>
    <name>A0A1V0N643_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N643"/>
    <dbReference type="STRING" id="74969.FAD_1735"/>
    <dbReference type="KEGG" id="fai:FAD_1735"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="28125" checksum="6FE24C9A02B18927" modified="2017-06-07" version="1">MENIYIITHYKKIMQARKFLTDHNRIFIPLISILYSLMIFTISLFYAFLILLIFSIPVVIFLLMHFFGMYRFKPRLFGGIVILLVVLMISAGIYSTYVYDLNGVTTSDINGTSLKTSITPFSGVDHNYNITITTNYTGSLNNSYLYIYSSGIYNKTVHYSNLNHTKNGNITTMYYDTKLPSGLYDTNYTINKTLTITSAGPVNVPRLTFYEFYVFALADKYIASIGVMYIAGIVAAYFFSKKNLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N662</accession>
    <name>A0A1V0N662_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit Rpo6</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpo6</name>
        <name evidence="3" type="synonym">rpoK</name>
        <name evidence="4" type="ORF">FAD_1762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N662"/>
    <dbReference type="STRING" id="74969.FAD_1762"/>
    <dbReference type="KEGG" id="fai:FAD_1762"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="59" mass="6558" checksum="50E014AC31E3C9F7" modified="2017-06-07" version="1">MISMMLTKFEKARIIGARALQIAMGAPVILDVSPDMIDPIDIAIFEFDNGVIPITIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N688</accession>
    <name>A0A1V0N688_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aminomethyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143112.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N688"/>
    <dbReference type="STRING" id="74969.FAD_1832"/>
    <dbReference type="GeneID" id="31677322"/>
    <dbReference type="KEGG" id="fai:FAD_1832"/>
    <dbReference type="OrthoDB" id="2001at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="9">
        <location>
            <begin position="293"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="368" mass="41629" checksum="4B7A2EE4939FB397" modified="2017-06-07" version="1">MEVKNSTPLRTALYDEHKKLNATMIDFHGWDMPLQYTSIIKEHMSVRNDVGMFDISHMGDIVISGPGSDNYVDYIFPSRISLLKNNECMYTAFLNPSGNMIDDTIIYRLSGEKFFLIPNASNIDKIYKWMIDNKKDYDVTIENYSNIISHIAVQGPKSVDVLKNLGMEFPEQFKFLYSDAKKYNAITGKNEIIISGTGYTGEKGVELIVPNELAADMWNSVLNEVKKLNGLPCGLGARDTLRMEKGMLLSGQDFNENKNPYEASISFIVNIDHEFIGKEALMKQKNEYTDIFRGFKLENRNIPRNGFNIYINGNIEGTITSGTVSPILNTGIGLGYINRKYSKSGTEAFIKIRDNMVKAEIVKPKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N690</accession>
    <name>A0A1V0N690_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886899.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N690"/>
    <dbReference type="STRING" id="74969.FAD_1757"/>
    <dbReference type="GeneID" id="16025032"/>
    <dbReference type="KEGG" id="fai:FAD_1757"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43257">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43257:SF2">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="321" mass="35225" checksum="DE7B824C5892287B" modified="2017-06-07" version="1">MTQMTMVKALNSGLNNAMEKDDSIILLGEDVGTDGGVFRVTDGLLAKYGKERVMDTPLAELGIVGFGIGMSMAGLKSIPEIQFQDFIYTAMDQIINQMAKLRYRTNGDYTLPMVLRTPYGGGVHGGPYHSQSGEAYFTHTQGLTVVTPSNPYDAKGLLLSSIELNDPVIFLEPKRLYYAGKMDVPDDYYKVDLRKASVIREGDDLTIITYGPAVPVVKSTVEKNNVNAQIIDLRTLSPFDLDTILAGVKKTGKVLIVHESPKMFGVGAELSATISEKAVDYLAAPILRVTGLDIPIPFALEEYYVPNERRIMAAIDKLLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N699</accession>
    <name>A0A1V0N699_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1841</name>
        <name evidence="2" type="ORF">HLB00_06880</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000246">
        <property type="protein sequence ID" value="NOL60554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886989.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N699"/>
    <dbReference type="STRING" id="74969.FAD_1841"/>
    <dbReference type="GeneID" id="16025122"/>
    <dbReference type="KEGG" id="fai:FAD_1841"/>
    <dbReference type="OrthoDB" id="56850at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012440">
        <property type="entry name" value="DUF1641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38433">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38433:SF1">
        <property type="entry name" value="DUF1641 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07849">
        <property type="entry name" value="DUF1641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="215" mass="23436" checksum="641770D2372EC76A" modified="2017-06-07" version="1">MMSEDEQLEKLMKPEYISSLTRAIELIRKLDNLGFLDVISGILSDDETLKTVFSLLTSDDVLSLTTKTDSVMVLLKIMSEEKNVKALSNLLEIVTVIQNKGLIDPVMGILKDDAAMGAIMGLLSNDFTMNLLMNEKPILASLGTLDLSVAPHYVNMIKAVENAIKTDTVTPVGGMMGTLRAMKDEDAQKGLGIVFSILRSLGKTCSDEFNCSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6B1</accession>
    <name>A0A1V0N6B1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A-type ATP synthase subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ntpH</name>
        <name evidence="2" type="ORF">FAD_1818</name>
        <name evidence="3" type="ORF">HLB00_01790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000045">
        <property type="protein sequence ID" value="NOL59567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886967.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6B1"/>
    <dbReference type="STRING" id="74969.FAD_1818"/>
    <dbReference type="GeneID" id="16025097"/>
    <dbReference type="KEGG" id="fai:FAD_1818"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="107" mass="12633" checksum="C1E26E26CE191BF4" modified="2017-06-07" version="1">MTEIDELKVIKNKEEAKKRSIAELKEEMEKQLNQQIAECNEKAKNLENQIINDYNKAIEEIKKSESRKMADALDTQRARSNVMKVDISNRKLEEKVYNLILEYITKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6C3</accession>
    <name>A0A1V0N6C3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1787</name>
        <name evidence="3" type="ORF">HLB00_08010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000298">
        <property type="protein sequence ID" value="NOL60770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143089.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6C3"/>
    <dbReference type="GeneID" id="84218410"/>
    <dbReference type="KEGG" id="fai:FAD_1787"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="183" mass="19427" checksum="9522884F81E39A86" modified="2017-06-07" version="1">MNKKILAIGIVMIILGIAMAAGGTEYFQSSFNSVSNSHYTYNATTALNVSNPIHIKTGYLVLIEGSVGDSGLVTHSNLSMVTNLTALKSHEEKVTDSSDGIELFLGLPAGTYNYVYANNTTSTAPTYGYITGGQFDTMAGLAVGGVLIGIIGFIVMIYGAIKKEKPKNPYAADDPYNIDNIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6C7</accession>
    <name>A0A1V0N6C7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143105.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6C7"/>
    <dbReference type="STRING" id="74969.FAD_1815"/>
    <dbReference type="GeneID" id="31677305"/>
    <dbReference type="KEGG" id="fai:FAD_1815"/>
    <dbReference type="OrthoDB" id="10763at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="96" mass="10821" checksum="250E6A1CB10FBED3" modified="2017-06-07" version="1">MIIADVTFYPIGKGVSVGDTIEKVVSRLKNNNSIKCYPNSMATVIECSNIDILMDAIKDAEKFIENMGFPRVETILRIDSRTDVENSVERKMKYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6I0</accession>
    <name>A0A1V0N6I0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="12" type="ORF">FAD_1850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3 9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6I0"/>
    <dbReference type="STRING" id="74969.FAD_1850"/>
    <dbReference type="KEGG" id="fai:FAD_1850"/>
    <dbReference type="OrthoDB" id="5877at2157"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000007">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="10">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="11">
        <location>
            <begin position="185"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="413" mass="46887" checksum="BC05F7373CA7DAAD" modified="2017-06-07" version="1">MLNIYKKYHIYRKYLIPMDKVLLLYSGGLDTSVMAKWIQKEMKKEVVTLTLNIGNSNLQKIKEKALGLGVSDAIVLDVKNEFSEKYIAKEIYADGMYEGYPLSTAIARPLMAEKAVLYAEEYGCNTIAHGSTGKGNDQVRFEVTMKALNEDINVIAPVRDWNMNRPDEIKYAKANGIDIPMGGKYSVDENIWGRSVEGSSIETVSNPLEYDVYEWVKPLEETGNGDIIDIEFKNGVPVSLNGEQYALKELVEKLNVIAGNNGIGLINHMEDRVTGIKSHEVYEVPGAMAIIQAHKMMESLTLNKSELDIKNYMDNQWSNFVYNGLWYDPVMEHINQFESSINKYVNGNIKLKLYKGNIVMQSIESENSIYNYDKISYDNSNFNQDSAKGFIDIYKNNTVYASNARKEKIKLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-07" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q2PCE3</accession>
    <name>Q2PCE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-D-glucoside glucohydrolase 1</fullName>
            <ecNumber evidence="6">3.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gly1</name>
        <name evidence="5" type="synonym">glyFa1</name>
        <name evidence="5" type="ORF">FAD_0868</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2006" name="Environ. Microbiol." volume="8" first="416" last="425">
            <title>The 'pH optimum anomaly' of intracellular enzymes of Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Golyshin P.N."/>
                <person name="Timmis K.N."/>
                <person name="Ferrer M."/>
            </authorList>
            <dbReference type="PubMed" id="16478448"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2005.00907.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Type strain: DSM 12658</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ850916">
        <property type="protein sequence ID" value="CAH64535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142093.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2PCE3"/>
    <dbReference type="STRING" id="74969.FAD_0868"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="31676371"/>
    <dbReference type="KEGG" id="fai:FAD_0868"/>
    <dbReference type="OrthoDB" id="11098at2157"/>
    <dbReference type="BRENDA" id="3.2.1.20">
        <property type="organism ID" value="10776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH64535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="246" mass="28318" checksum="3354D9C40BE7D16A" modified="2006-02-07" version="1">MEIQDIDLTIVLATLNEIDNLPRLCSDIDSILKNTKIKYQLLFVDDNSSDGTREFIIEYCNKNKLSKYIFNEYKKSTLIARYQGINNADGKYIILMDSDLQHPPKYLLNIYNSLLKHNDIVIASRYVKGGSTGNRKPIRGIISRGASLMAQLLLKSSRQIKDPISCYIGFRKGLKLDIDEGWRGYEIGIFLRASNNNVKVKEIPYRFAERENGKSKVTSSVKFLRVYIIELLLAKRVEIRNYKPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1E8</accession>
    <name>A0A1V0N1E8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141233.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1E8"/>
    <dbReference type="STRING" id="74969.FAD_0007"/>
    <dbReference type="GeneID" id="31675521"/>
    <dbReference type="KEGG" id="fai:FAD_0007"/>
    <dbReference type="OrthoDB" id="8709at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030554">
        <property type="term" value="F:adenyl nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043168">
        <property type="term" value="F:anion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010344">
        <property type="entry name" value="PRK13771.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD83943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="336" mass="36593" checksum="2BC4A8B3C0E87590" modified="2017-06-07" version="1">MQAGFLNKLNSEIILEDYEPPEPRDNEVTIEQKYTGVCFRDILTQQGFFPRVSLPVIPGHEIGGIIIKKGKNITNFNIGDRVSSLIYVPCGKCEFCLSGNENLCPNKVAYGEGRNGGYSRYVNADERSLVKVPPEVPEETVPIAACVIAMLYHAIGRVGKIKKGDYVLITGAGGGVGVHAVQMVKALGGHPIAETGSKWKEEELYKLGAEYVVSPEREYNKDVKEITGQGADIVLEDVGIATFSKSLRSLKTGGRLVVIGNLKPEPVELPLGLIILKGNSIKGSISSTREDLKKALELSKSQISPVIGNKIELQDINNGYANMLDRKVLGRLLIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1M9</accession>
    <name>A0A1V0N1M9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0063</name>
        <name evidence="2" type="ORF">HLB00_07390</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887072.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1M9"/>
    <dbReference type="STRING" id="74969.FAD_0063"/>
    <dbReference type="GeneID" id="16025208"/>
    <dbReference type="KEGG" id="fai:FAD_0063"/>
    <dbReference type="OrthoDB" id="55633at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017185">
        <property type="entry name" value="UCP037373_trxn_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037373">
        <property type="entry name" value="UCP037373_trxn_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD83996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="118" mass="13853" checksum="86B4E9487559D618" modified="2017-06-07" version="1">MALSEEVNKLAKYLMVSDIPRSVAYTLVYIKDKGEITSVEVERETGLRQPEVSIAMQWLRRKNWIAKRNMKKEGKGRPVHGYKLSKDFNEILEEIINEREKKIDEINSTINQLKNFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1P6</accession>
    <name>A0A1V0N1P6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 6</fullName>
            <shortName evidence="3">aIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif6</name>
        <name evidence="4" type="ORF">FAD_0078</name>
        <name evidence="5" type="ORF">HLB00_07315</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141296.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1P6"/>
    <dbReference type="STRING" id="74969.FAD_0078"/>
    <dbReference type="GeneID" id="31675590"/>
    <dbReference type="KEGG" id="fai:FAD_0078"/>
    <dbReference type="OrthoDB" id="33582at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="218" mass="23346" checksum="12A4EB0EEC5EA8C5" modified="2017-06-07" version="1">MIKKLSIFESDFIGVYAKVFNDFAFLPRNIPEETRLSIEETLKVKTAGVIVDNFSLIGTMLVFNSNGIVVSGLSSKEDFSGLDLGGRRLFFLKDRLNAIGNNIITSDRAAVIHPSFTESSEKAIADTLGVEVIKTTIAGVSTVGSVAVLNNKGMLVSPEASEEEIKNLSDIFHLPVKTGTANYGSYYIGASILANSSGILVGNATTSIELGRIDDIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1P9</accession>
    <name>A0A1V0N1P9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative signal peptide peptidase SppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141301.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1P9"/>
    <dbReference type="STRING" id="74969.FAD_0081"/>
    <dbReference type="GeneID" id="31675593"/>
    <dbReference type="KEGG" id="fai:FAD_0081"/>
    <dbReference type="OrthoDB" id="31107at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047272">
        <property type="entry name" value="S49_SppA_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42987">
        <property type="entry name" value="PEPTIDASE S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42987:SF4">
        <property type="entry name" value="PROTEASE SOHB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S49" evidence="5">
        <location>
            <begin position="61"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="239" mass="26493" checksum="098BB02EE74C943C" modified="2017-06-07" version="1">MYIGVLNFKGTITGSSPGTYMPALRYIERKNKVKALLIVINSGGGDANATEILYNQLMKISSKKPVYALIEGIGASGAYWLACSAEKIFAMRTSLVGSIGVISMSPDFSEFLDTLGIKMRINKVGKYKDINSPFRPMTEEENTIYNNIMKDVYSVFREEVKKRRNLGEDIMEDIATGLVFSAEQAKKNGLIDGIANLETVVDELKAKTGTNSIKNLTPKRPFISRLMSMSFEAIYNVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Q2</accession>
    <name>A0A1V0N1Q2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Q2"/>
    <dbReference type="STRING" id="74969.FAD_0117"/>
    <dbReference type="KEGG" id="fai:FAD_0117"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000038">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="10"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="111"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="305" mass="34422" checksum="D469334C7BAF230B" modified="2017-06-07" version="1">MAFSSMYGKVLICDPVDNVMTDKLKDKFEIDYKPKISPQELLEVIKDYDVVVVRSRTKITKDVISNGKKLKIIARAGIGVDNIDTDYAEEKHIKVVYAPGSSTESVVEITLAMMVIGARSLYKGMENTRKNDFTKLKGMELEGKTLGILGFGRIGKAIVDASRTFKMKFIAYDPMPVEYPEYVKKVSLDELLEQSDVISINVTMRKDSPYILNDNELSKLKEGVIIVNTSRARAINGKDMLKYLKNGKISAFVSDVFWNEPAKEDYELEMLKLDNVMITPHLGAQTKEAQKRIAIMTADNIINEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1S7</accession>
    <name>A0A1V0N1S7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">marC1</name>
        <name evidence="8" type="ORF">FAD_0126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141364.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1S7"/>
    <dbReference type="GeneID" id="31675638"/>
    <dbReference type="KEGG" id="fai:FAD_0126"/>
    <dbReference type="OrthoDB" id="10856at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00427">
        <property type="entry name" value="NAAT family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="UPF0056 MEMBRANE PROTEIN YHCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508:SF1">
        <property type="entry name" value="UPF0056 MEMBRANE PROTEIN YHCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="209" mass="22763" checksum="57A97541A3FCAB9E" modified="2017-06-07" version="1">MAILLLFITVFVALFAIMNPIGAVPILITLTDGYSLKERKEVIRRSVYMASGMVFGFMFLGVYIFDILGISIYDFEIAGGILLFKVGFDMLQGKTSTTKITNAEQQDSADREGIAIAPIGTPLLAGPGTITTAIIYFNRAGIDIFSRLMVVLAVILVLILAFIILRYSLPIFQKIGKTGSIVISRIMGLLLTAIAIDLITTGIIHIFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1T9</accession>
    <name>A0A1V0N1T9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl30</name>
        <name evidence="6" type="ORF">FAD_0180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887185.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1T9"/>
    <dbReference type="STRING" id="74969.FAD_0180"/>
    <dbReference type="GeneID" id="16025328"/>
    <dbReference type="KEGG" id="fai:FAD_0180"/>
    <dbReference type="OrthoDB" id="6379at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_A">
        <property type="entry name" value="Ribosomal_uL30_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005997">
        <property type="entry name" value="Ribosomal_uL30_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004711">
        <property type="entry name" value="PRK06049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01309">
        <property type="entry name" value="uL30_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="164" mass="18403" checksum="F5DD825B48596885" modified="2017-06-07" version="1">MIAIIRIRGSTGIKPFAGKTAELLNLNRINHMVLFQESESLNGMLNRVKDYVTWGEVDTETLELLLKERVLLNGRKKLTEDYLKSSGYSSIEELAKALSENKVKIKDLPDVKPVIRLNPPKGGYEAIQKPFHQNGSAGYRGSKINNLIRRMIVPGVDLNGKDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1U4</accession>
    <name>A0A1V0N1U4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-canonical purine NTP pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887141.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1U4"/>
    <dbReference type="STRING" id="74969.FAD_0135"/>
    <dbReference type="GeneID" id="16025280"/>
    <dbReference type="GeneID" id="31675647"/>
    <dbReference type="KEGG" id="fai:FAD_0135"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011396">
        <property type="entry name" value="PRK14821.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="182" mass="20600" checksum="FA4342B91EBD529C" modified="2017-06-07" version="1">MIKFVTSNSHKYEEAKALFKSKNIELSWVKMEYEEIQAEDNELICRDSCMKLTEKIDSPFFIDDTGLYIKSLNGFPGPYASYVQSTLGNSRIMEIGAGSEAHFKTVIGFSMESEIYTFTGILNGHIAKKESGTNKFGYDPIFIPEGYDKTLAELSTEEKNIISHRGRALDKFMDFLSSRGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1U7</accession>
    <name>A0A1V0N1U7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl18</name>
        <name evidence="7" type="ORF">FAD_0178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887183.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1U7"/>
    <dbReference type="STRING" id="74969.FAD_0178"/>
    <dbReference type="GeneID" id="16025326"/>
    <dbReference type="KEGG" id="fai:FAD_0178"/>
    <dbReference type="OrthoDB" id="8644at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057267">
        <property type="entry name" value="Rbsml_uL18_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006342">
        <property type="entry name" value="PRK08569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="157" mass="17458" checksum="3C5D56B438BB549A" modified="2017-06-07" version="1">MKTTPVLKRRNLGITDYQKRYRLLKSNVTRAVVRPTNKGLMIEFVDYSPSGDLVKVTVTDKTLQKEYGVYGNNIQAMYLAGYLAGKKAAEKGIESAIFDTGRYKFIHGGRLAAALKGIVDSGIEIPASEDVFPDESRINGEHLKNKVDISKYVKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1X1</accession>
    <name>A0A1V0N1X1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Agmatinase</fullName>
            <ecNumber evidence="7">3.5.3.11</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Putative arginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">speB</name>
        <name evidence="6" type="ORF">FAD_0225</name>
        <name evidence="7" type="ORF">HLB00_06545</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000233">
        <property type="protein sequence ID" value="NOL60491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1X1"/>
    <dbReference type="STRING" id="74969.FAD_0225"/>
    <dbReference type="KEGG" id="fai:FAD_0225"/>
    <dbReference type="OrthoDB" id="7186at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11593">
        <property type="entry name" value="Agmatinase-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="287" mass="31833" checksum="E6A0D22431E153C6" modified="2017-06-07" version="1">MSQFSNLKIADALASYEDADYVIFGAPFDNTSSYRRGSRLAPNSIRAAYDNLESYEVNYGINLLDAKICDLGDLPVYEDVDYILSEIETATATIFHDKKIPVMLGGEHSLTVGALRNLKDITMVIIDAHSDFRDSYMGNKNNHACVTRRALELLGKNKIISIGTRSTSYEEIASGEYENVRFISANEVRASGIDEVISEVMEKTSDRVYFSIDMDGFDPAYAPGVGTPEPYGLTSYDVRSILTSISDRIIGFDINEMTPLYDNGNTSMLAAKLIQDFIASREKALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Y1</accession>
    <name>A0A1V0N1Y1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FAD_0235</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an archaeal dolichyl phosphooligosaccharide + [protein]-L-asparagine = an archaeal dolichyl phosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.</text>
            <dbReference type="EC" id="2.4.99.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887243.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="STRING" id="74969.FAD_0235"/>
    <dbReference type="GeneID" id="16025388"/>
    <dbReference type="GeneID" id="31675744"/>
    <dbReference type="KEGG" id="fai:FAD_0235"/>
    <dbReference type="OrthoDB" id="82393at2157"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2033"/>
            <end position="2055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ARD84160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="2061" mass="223575" checksum="F799A50726F85499" modified="2017-06-07" version="1">MEITDRFKQNIARHPEVPVLIALLALYMFLSNFFVWSLAFQDNYLNVSGGSDPYFNYYIVQYILSTHTQLTHTILLNYPVGTFNARPPFYQWSIVFAGYILSPFVGVKMGAYYAFMESDAFYGALLIIPVYLITKQIFGKKAGLFAAVLFTIMPGNLTSGILTDGRAHTPELIFAFLSIYFFEMAVITAKKRVIINKLTDTRSYFSSIKNYYEENKIATIYALMSAVSLGGLIVFWQGFPYIEVILLIYVAVQLLYNLFTKKPTGYLTYISTIYVAASFPIGFYYYDVTFMIHAWFLPPLAMGLMIIGFGILINIVARRPWIITIPALVLVTIAGLFVISKTNPAILKELITGDGYFVKSRVYSTIAEAAAPALGQYISDFGPGLFLLGIAGVPFIIYRFLKEKKEATLLVIIFAIFSIFMSFEAARFNITAAPAYAILGGGLIMYFVDKIRHNESTKKSRHVSGRKSLRKNISGVTIGFAVIVVLILIIPSGMGAFSAAVPENNAASYNHILNSTVPKGIRPNNPFGNYGLAIDNKTQPIAASFNWLATQNTNQSIENRPAYVSWWDYGFQELQQGQHPTVADDFQQGIASAGQMLLAQNQTQEISLFISRVLQTPGGYSNGHFNASITATMHKYFGVNETNTIANMYGNPLNSSYTPLLSETAYGGHQINVTSSYNARHALIMGQLSTKYNLSTLVNAYSALEKVTGSSISYIQVDHSLYPFSGSNPGIFYAPAYLTDTPSYTADGEVVPTNYYNVVAVTNTGAQYTLNNLPTGVTVSNYLLNYTSAFYNTTIYKTIYGFPESNINNVTHVYPAFNMSNFELVYYASEYNPAKDANNSTPGWTLIPLQTAYKYQQEGKGTEVLLPASLIGNEDPIINYYPGAVIHGQITNANGIGIAGVHVTIEDQYGIPHEVVTTNSTGYYSITGLPGNDTLVYSTGSVNSDTLNGTNVIGTQSVAVSQNQGNRIGNYNITQNMHMARNSVYGYVTVDNGTSHASINSGTITLTNSTYGINVTAPITNGMYSLSNVIPYGYNATITSNGKTYTNFTTLQVTGKSQQLSNLTVKMDSIKVTASVSGSGLSGYTAYLNSTSGNYQLTGVTSSSGTYTFGVYPGTYNITIKANGTEDKSVATVSGWGKSKSVSLTPELTAKVSGNATPYAKISFYFDGQISDYKNVTANASGAYNISMPYGIYTIYSTNTSGGVFAKTINVTGNAVQNISYSPAVKYKISSTMNTTKYYSGTYEILAANSTGQHYTLLDYNYANSSIPYTIYLPSAKYSFAGTGTYNGKTMAGFNISTTATSVNINLTDSDSHSILTSTNNTIGYVSQGIMLVYNNSTPYYYTEISGGTGKVYGYNTSTVGIQSPYYYNSTIPINSSIYYAKQNMVSVSMSVYNDSKLTNYTGTITLTGLYNTYTLNMTKGVASKEIAMGVYYTQVSNNSAYIVPDLTGTVVNSSASQSFVKNSNLYFTFKNSNTTITGSGTTLFNSTGVNVGLNHLPAGTYTLYSVNATLVNMTTITLDKNTSLSPVYHTGYNLSITNNLSISAAYHIKNGSMEITTSSSKNLTIMLPDINFTITSSGNFTNSTGAYTYVNTSTPANNVTPGAAVHNFKVNLTPKEVYDKISGNVYLKGTNVSGVNVILTKNGKQIDNTTSSSTGFNLTKLVPGTYGLYANYTTAGGNEYAYFQNVTLQPFKNLTYNISLMPAYKVTLGGLNNTNSSVPTQLTVTGGSPISPSMYITSTGESNSIILPGNETYNFTITNTTVQSGITVNYSASQTIFLNNTDNKQLTLHKDYVSRYILMDPSVTGYIGENVTTTVKVYNKGTTNDTLHLYSGNSTWALSFSPYNLTVPMGANKTVVVNITIPIAKAGNNTVDVMALINGTSHYIGNITVDVEKGSSYNVSYSKYAEVNGTLNMIPVTIKNTNNTALTINLGVINSSKLLSDYDIVAYATENGKNVTNVTLSTGQSVTIYILAYGINGRTLHSVPIEFETNATINGKLTYQNETITPVLPSATVGTGSSGDHIISNYNKNPAITIYIGIGIIVAALLAGVIGSSIRSRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Y8</accession>
    <name>A0A1V0N1Y8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Large ribosomal subunit protein eL32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl32e</name>
        <name evidence="6" type="ORF">FAD_0176</name>
        <name evidence="7" type="ORF">HLB00_02300</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000069">
        <property type="protein sequence ID" value="NOL59665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887181.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Y8"/>
    <dbReference type="STRING" id="74969.FAD_0176"/>
    <dbReference type="GeneID" id="16025324"/>
    <dbReference type="KEGG" id="fai:FAD_0176"/>
    <dbReference type="OrthoDB" id="372100at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00810">
        <property type="entry name" value="Ribosomal_eL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023654">
        <property type="entry name" value="Ribosomal_eL32_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006332">
        <property type="entry name" value="PRK08562.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="134" mass="15844" checksum="D553B1AFC671A66A" modified="2017-06-07" version="1">MSYKPLLTKEQKVLLKKKNEVNRRRVEFHRQEWFRYKKFDDSWRRPRGKHSKLRTHLGYRSPVVGPGYRTPRAVRGLHPSGFREVLVHNVNELSKINPDLEGARIASSVGYRKRIDIESEADNLGIHIFNRVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Y9</accession>
    <name>A0A1V0N1Y9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps8</name>
        <name evidence="8" type="ORF">FAD_0174</name>
        <name evidence="9" type="ORF">HLB00_02290</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000069">
        <property type="protein sequence ID" value="NOL59663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074184.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Y9"/>
    <dbReference type="STRING" id="74969.FAD_0174"/>
    <dbReference type="GeneID" id="16025322"/>
    <dbReference type="KEGG" id="fai:FAD_0174"/>
    <dbReference type="OrthoDB" id="5670at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_uS8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="129" mass="14404" checksum="751938CF75C3E9EF" modified="2017-06-07" version="1">MKSDPLNDVINTIKMASRIGENEITISPASRIIGRVLKVMQDYNYIKSFEVIEEERGGKFSVVLSDTINNCGVIKPRLSVTRSSIGRYESRYLPAQDFGIIILTTTKGVMSHLEARKFGIGGKLLAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N202</accession>
    <name>A0A1V0N202_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps13</name>
        <name evidence="9" type="ORF">FAD_0260</name>
        <name evidence="10" type="ORF">HLB00_03145</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000099">
        <property type="protein sequence ID" value="NOL59829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887281.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N202"/>
    <dbReference type="STRING" id="74969.FAD_0260"/>
    <dbReference type="GeneID" id="16025427"/>
    <dbReference type="KEGG" id="fai:FAD_0260"/>
    <dbReference type="OrthoDB" id="372127at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000001">
        <property type="entry name" value="30S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019977">
        <property type="entry name" value="Ribosomal_uS13_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03629">
        <property type="entry name" value="uS13_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="159" mass="18624" checksum="61C8C2036B3B0A75" modified="2017-06-07" version="1">MADNKKDNENFQYIVRIANKDIRGERRMDLGLADINGVGERLANILIKKLNLDRNRQIGDLSEDEVLEIRKYVESKEYEGMPVWLLNHRKDVATGKNFNLLSNDLILKINDDINLMKKMRSYRGLRHEQGHKVRGQRTRSNGRHGLSMGVIRKRQEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N213</accession>
    <name>A0A1V0N213_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeosine tRNA-ribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeosine synthase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141416.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N213"/>
    <dbReference type="STRING" id="74969.FAD_0222"/>
    <dbReference type="GeneID" id="31675731"/>
    <dbReference type="KEGG" id="fai:FAD_0222"/>
    <dbReference type="OrthoDB" id="115061at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10630">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040777">
        <property type="entry name" value="DUF5591"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17884">
        <property type="entry name" value="DUF5591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF5591" evidence="5">
        <location>
            <begin position="229"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="466"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="524" mass="60480" checksum="E0E7A1B3B27023C6" modified="2017-06-07" version="1">MSEKINDKQYVMGFTWAGYRNGRRFPLLINTFSNDYKNDKDSIEILGEKFSRKIYYPSFLGGEKVIEGNEMVIIYNGLELIQRPARLIAFIMELRKKYGFKKMFYLQGISDPYLLPVLSYLGINIFDDLYIRKESQENLKYTVAGKTKVDYNPLEENIKFAESILDSIFLATRDGTLREIVEKIAISGKALEILRIADTKYYNEFSQVFPSRTPYIQANSIESLNRPDIAYYRNKIAEYTKPEHRNIALLLPCSAKKPYSDSKTHKKILAGIWQYRRYLHELIVTSPVGLVPRELENGYPARFYDIPVIGTWYEDEKVMMKNLISSYMKKNNYSEIIAYIPEDLDFIRESLPENSKIIEGRVTDDGNIAKLASVLKDTITGDSEYAKKLDDYRAILRFQFGEWIMPYLSKIKLINSFHQDMLVEDGKILFVYNESIGRFSITHESGKFFMENNKFNVSIEDFNPTSSVYAMGIRDATTDIKAFDEVVMTYGNELRGTGTALMPSRAMVDMDHGAAVKVRSGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N217</accession>
    <name>A0A1V0N217_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translation initiation factor 5A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Hypusine-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">eIF-5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">eif5a</name>
        <name evidence="13" type="ORF">FAD_0224</name>
        <name evidence="14" type="ORF">HLB00_06550</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Berkeley</strain>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions by promoting the formation of the first peptide bond.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000233">
        <property type="protein sequence ID" value="NOL60492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887233.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N217"/>
    <dbReference type="STRING" id="74969.FAD_0224"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ribosome binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="Rib_uL2_dom2"/>
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        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
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        <property type="entry name" value="Transl_elong_IF5A_arc"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK03999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF5A"/>
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    </dbReference>
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        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 11 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="12">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hypusine" evidence="11">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD84149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="NOL60492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="129" mass="14640" checksum="6ABE30DB186EB895" modified="2017-06-07" version="1">MSWTEAEVRELKVGRYMLIDDSPCKIVDITMSKPGKHGEAKGRIVAIGVFDGQKHSVVYPVKHKIKVPIIVKKNAQILSIANNEAQMMDSESFETFILPIEPEDQDKLKPGMEVPYWEAMGKRKIMLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N235</accession>
    <name>A0A1V0N235_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl10e</name>
        <name evidence="5" type="ORF">FAD_0226</name>
        <name evidence="6" type="ORF">HLB00_06540</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ARD84151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="NOL60490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841616.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00448">
        <property type="entry name" value="Ribosomal_uL16_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022981">
        <property type="entry name" value="Ribosomal_uL16_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="176" mass="19444" checksum="02BF0BFFFD127323" modified="2017-06-07" version="1">MVTKPARMYSKISGPAYTRKEFMGGVPYPKITTFVQGNQKREFEIEMQLVAEEACQIRHTALEAARISINRKLLENVGAGNYFLHIRVYPHQVIREHKMATGAGADRISSGMRMAFGKPVGTAARVHIGEIIMVGKVDRASAKTMKDALKKASIKLPTPCKVIITKGKEITSKMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N255</accession>
    <name>A0A1V0N255_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MULE transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N255"/>
    <dbReference type="STRING" id="74969.FAD_0251"/>
    <dbReference type="KEGG" id="fai:FAD_0251"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="560" mass="63395" checksum="8A4392B910AEC490" modified="2017-06-07" version="1">MISEIIFRTDRTVCPQCHSRLVEYKTERRTIRSWEMGEFTAVHKIMGCRRHGTMFRSERLKSIVNPHCIYANDIMIEASMGRFIHGLSCSEISEQGGMRGISGSHARNVTNMALRILSRIHEESWKKLKGAMHNYVLQIDGTTDSKFDMIVVVRDSISNFTLHAEKYASESYENIKDILMKVKERFGSPSGSISDMRSGILTALAEVFHGMPIRICLMHFLRDLGKGLMVDMHNNLGLKINRKGIKSALKSILRSMPDYDQNTLEEIENGFCSDRGKMEIMAIRRIIEPVLSVNGSSGYGFPFSLNHLNFFTSLKEAGKLLSELSEKAAGEESMELISSARKYIGRIVTDQSIVETAKKLSEVNMLFQKLRFAFRIPEKGNLSDDIPDDASIHDQCNTVIGEMEVYLHENIAPHIIRAAKHIIERYHEREIMLFANNADGTMPRTNNGMERFFRKIRRNVRKRNGNTATGHVLAQSGVQLALFQNLDNPIYVKTVFGSDGISAVFAKRREHFRKPGMTVSTVNKLVADGTRMILEDNLSDTPYNDQMMNAAQASRNIQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N263</accession>
    <name>A0A1V0N263_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141497.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N263"/>
    <dbReference type="GeneID" id="31675827"/>
    <dbReference type="KEGG" id="fai:FAD_0318"/>
    <dbReference type="OrthoDB" id="383919at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15839" checksum="66D32DA76349C399" modified="2017-06-07" version="1">MDQKYSFAYLGITAIMALLFIQFILGMYVNLYVSFPPLNNVSHLAGNSFPSNYIVVMVHMMFGFLILIVAFILLLLSVKIRNSKLVLSSAISLVFVIVAGISGLLFLFNEANLYSLIMAVSFIIIVLSEFYYLYVIKVSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N286</accession>
    <name>A0A1V0N286_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Folylpolyglutamate synthase/dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141506.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N286"/>
    <dbReference type="STRING" id="74969.FAD_0326"/>
    <dbReference type="GeneID" id="31675835"/>
    <dbReference type="KEGG" id="fai:FAD_0326"/>
    <dbReference type="OrthoDB" id="75177at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="8">
        <location>
            <begin position="43"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Mur ligase C-terminal" evidence="7">
        <location>
            <begin position="292"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="428" mass="47697" checksum="6BE2BA5F20576470" modified="2017-06-07" version="1">MINGALDYLYNLKREGIKLDLTATQDFASHVGNPQSKFKTIHIAGTNGKGSIASYVYNILRQKYKTGMYTSPHLLDFNERIILDLNMIPDSYIIDFMNSNRDYIENLATVYRNPTFFETTTVMAFKYFADNNADYAAIEVGLGGRLDSTNIINPEVSVIAQIGYEHYQRLGCSLTSIAHEKGGIIKNGKPVVLLDNKPEVVAEITKIASVRNSKLVKISDYCSITDLKFNLDGMSFKLQTPVEEYHITTSNLGLFQLGNISTAVASMELLPEGSPGKKSIEKGIRESRWPSRFEVISREPLVIMDSSHNPPAAHALVETFSNFVTQKPVLLIGMLDDKDYFSYMSILRKLSDSVILTTPDEPSRSLDPDALAAGIGHMFPSIRIIKDPVEAYNFAIQNYSCVLVTGSMYLVGMLKKYLGSSVRPFNMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N288</accession>
    <name>A0A1V0N288_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2269 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0284</name>
        <name evidence="3" type="ORF">HLB00_04370</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000149">
        <property type="protein sequence ID" value="NOL60069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887306.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N288"/>
    <dbReference type="GeneID" id="16025452"/>
    <dbReference type="KEGG" id="fai:FAD_0284"/>
    <dbReference type="OrthoDB" id="57354at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="172" mass="19778" checksum="6ED3302A07E92F13" modified="2017-06-07" version="1">MYLDLVISQSEHNILFLILLSIHVLSAITFVGGSIFIWLILWPASYKMNDDKLRTRLLGFVGHRFAFWTNLTLGLLILTGLLMTYRYVLNPSLYFQSTGGELLFSAEILIIAMVIIMYGNNIYHGKLIVRLNEQGKLEEVKKIRKVTHIYSMITMVLLIIIVLLMVSITVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N296</accession>
    <name>A0A1V0N296_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C(20)-methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Precorrin-2 C20-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0337</name>
        <name evidence="9" type="ORF">HLB00_01970</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000052">
        <property type="protein sequence ID" value="NOL59601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887356.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N296"/>
    <dbReference type="STRING" id="74969.FAD_0337"/>
    <dbReference type="GeneID" id="16025502"/>
    <dbReference type="GeneID" id="31675846"/>
    <dbReference type="KEGG" id="fai:FAD_0337"/>
    <dbReference type="OrthoDB" id="23546at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43467">
        <property type="entry name" value="COBALT-PRECORRIN-2 C(20)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43467:SF2">
        <property type="entry name" value="COBALT-PRECORRIN-2 C(20)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="219" mass="24826" checksum="738B7D19B69D7A60" modified="2017-06-07" version="1">MSLFKVVGLGPGDPELITMKGYKAIMDADIVFYPKTSLNSAENILKSLGVNSNRMRELEFPIGSEKISALSREYAGMIMKASRDNLKSVYAVEGEPMLYSTFLDIMPYIDIEFDVIPGISSMNGISAAMKIILATKDEPLLVLPAVKDYSYMEEKIMSYGNVVIFKAIRAREIIKEIIKKNQLTNYYIMSYVSTEKEIIYNNIDDIKDYMTIVVIKRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2C8</accession>
    <name>A0A1V0N2C8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen debranching protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141538.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2C8"/>
    <dbReference type="STRING" id="74969.FAD_0362"/>
    <dbReference type="GeneID" id="31675871"/>
    <dbReference type="KEGG" id="fai:FAD_0362"/>
    <dbReference type="OrthoDB" id="8543at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006451">
        <property type="entry name" value="Glycogen_debranch_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024742">
        <property type="entry name" value="Glycogen_debranch_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01561">
        <property type="entry name" value="gde_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12439">
        <property type="entry name" value="GDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycogen debranching enzyme bacterial and archaeal type N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="1">
        <location>
            <begin position="263"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="610" mass="70189" checksum="41AE06A4BC367E02" modified="2017-06-07" version="1">MNFKEEWLIANSKGSYSSSTISFANTRTYHGILVKSEQNNYNRYVILSKLYEELAFQGKQYAIDTNYYPGTMWPEGFRYIQDYSTTPYPSLTFNLEGNICKKSLILDPDADTVVIRYEFPEKIPDMVNLYPLLALRSFHNVIKSGQKEFVADEDKGSYSFTDGIYSLKISKIGKFINKGLWYYNFIYPEEQERGTNSMEDLYLPGVISISNIKSPLDIAITTDDNFSGNFQDIQQRLTARGENNEGDPAINALRRNSYNFRLKNDLIAGFHWFGPWARDTFISMPGLLLIEKNFDMAREIFLNYAGKMKENLVPNNLYSQSFERSADAPLWFIYALYKYYAYSNDSSFVRSLLKNVRDIINSYISGNEDFSLDGKFIKVSNAPMTWMDAKNGNTSFTPRIGKPVEINALWYNSLKIYTYFCNISGEQPEKTVNDILSEFEDEFTGKFIINGEIADTIDPVDTSFRPNFLFAYSLPFPLLNQKQFLEKARLELVTPYGLRSLSPRSNKFAGTYSGPVMERDRAYHNGTVWPWLAGPYITACVRNGSNPDNLYRFFSDLYSMEMVPEIFDGLSPGEPRGCIMQAWSYGELIRAYYEDIRKYSPGTTVKRGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2D7</accession>
    <name>A0A1V0N2D7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141548.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2D7"/>
    <dbReference type="STRING" id="74969.FAD_0372"/>
    <dbReference type="GeneID" id="31675881"/>
    <dbReference type="KEGG" id="fai:FAD_0372"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="230" mass="26951" checksum="D5BBC87B62712BCF" modified="2017-06-07" version="1">MEYVKANGWQVYIDFFRNTQLDEFVNKINSTNAVKVENNFSIKNKKFRHVFHGIKSLPLFYDPLNRVNYLTLGFVYDSYGHLGFYRIEVRNNKEYIFIADKNYFKGKNGNIPVKIFNTCSVKYIIASSFHMDDKKKFILNYDNNNSFCQGIIPVNTNFIIDAEIMRDKETFQERISFGEEIINAKLDYNRLKIHRISFDEKKCSGILQGGNDHLFLYKLGNALGKIQGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2F6</accession>
    <name>A0A1V0N2F6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Signal recognition particle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">srp19</name>
        <name evidence="4" type="ORF">FAD_0411</name>
        <name evidence="5" type="ORF">HLB00_05010</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887443.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2F6"/>
    <dbReference type="STRING" id="74969.FAD_0411"/>
    <dbReference type="GeneID" id="16025589"/>
    <dbReference type="KEGG" id="fai:FAD_0411"/>
    <dbReference type="OrthoDB" id="56356at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="82" mass="9894" checksum="7DFA7348668AD785" modified="2017-06-07" version="1">MITLYSQYFNPAISRKYGRRISRERAKNYSDDKLEQILRTMNLKYEVRDAHYSRIPYEDSKMFVIDADIKKSTIIKIINEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2L0</accession>
    <name>A0A1V0N2L0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein eS24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps24e</name>
        <name evidence="4" type="ORF">FAD_0458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2L0"/>
    <dbReference type="STRING" id="74969.FAD_0458"/>
    <dbReference type="KEGG" id="fai:FAD_0458"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="100" mass="11927" checksum="2E9632858EF4ADE9" modified="2017-06-07" version="1">MIKNFSVDSERDNKLLFRKEIKYTIDFKSGKTVSRNEIKKLLMDYYKAKEEVIIVDHNIQETGKDSLKGYVKIYDTKEHAMLYEPDYELLRNGLKEKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2R4</accession>
    <name>A0A1V0N2R4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2R4"/>
    <dbReference type="STRING" id="74969.FAD_0479"/>
    <dbReference type="KEGG" id="fai:FAD_0479"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="71" mass="8247" checksum="7DF1B4BAE201E2C4" modified="2017-06-07" version="1">MRIVFNPVREGFLAFFYCAADSYYITALFTYYAAYGRFIQLIAHINTEIFSSIFPLNFIIVIQVSVHSFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2R9</accession>
    <name>A0A1V0N2R9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2R9"/>
    <dbReference type="STRING" id="74969.FAD_0476"/>
    <dbReference type="KEGG" id="fai:FAD_0476"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050833">
        <property type="entry name" value="Poly_Biosynth_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30250:SF11">
        <property type="entry name" value="O-ANTIGEN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30250">
        <property type="entry name" value="PST FAMILY PREDICTED COLANIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="500" mass="55773" checksum="77661023FEA5531E" modified="2017-06-07" version="1">MLVFGQVTNSLFGYIGLFFIIRFVGLQSWGYLSFSLAFIGVLSIIGDLGYGTAHLKYLSSGEYEEGVCTGTFLTIRTVQTLITISIVLGSLFIWINVLHRGFQSNVEIYAIILLLPYFFFARLKDVPIIYYNSKLKSARMSIPQITEAVVRNSLFIILGAVYILRIPGYNTVSAAILLAIIYSISYFIYFLLSVFLGRPWKVNRPSMELFKKYTKLAYPLALASIIGSVSGNIDKVLIEFYWHAVATGAFASLQRIASPITTFSGTISIFFIPLLMKSQGSSDKNFKTDISLFERIISIFILPLVIIFVVLRVYVANLWSAALIPYADILIFLTLAAYLVAINSAYSSSLVARGLTNKIGKITVIALIINISLDLLLIPPDVFEIRIFSLGVLGGAVSTFVAMLFETVAYRVTVIRAEKMKPDLRIFYQLLPILAQSMFLFGITSYIKIYSILLFIPVSVASVIVFLGVAVLSRQITLNQILEFIRALNPFSFGKQLHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2S7</accession>
    <name>A0A1V0N2S7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA primase small subunit PriS</fullName>
            <ecNumber evidence="11">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">priS</name>
        <name evidence="14" type="ORF">FAD_0548</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2S7"/>
    <dbReference type="STRING" id="74969.FAD_0548"/>
    <dbReference type="KEGG" id="fai:FAD_0548"/>
    <dbReference type="OrthoDB" id="31125at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00700">
        <property type="entry name" value="DNA_primase_sml_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023639">
        <property type="entry name" value="DNA_primase_ssu_PriS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 11 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="374" mass="44463" checksum="2B13ED40D2DC6DEA" modified="2017-06-07" version="1">MQYFREYYYKNHLGIPDMLFQREIGFIPFNGTMIRHKKFDSQNEIENFVRRAIPRHLYYSSSYYRFPDQHKMLEKEWLGAELIFDLDADHIEGADKMTYMEILAEVKKHTLRLLEMLMDDFGFEEKNIRLYFSGGRGYHVHVESDRIYTMDSDSRREIGDYIKIEGLNVEDLKLLDDSYFEYGILKKFNIYISNFYRNLDENYIKKVFPKSWWNYLEYLEKYYNGEKIRDFLSNEKGNKFKLLIKQNKSNENASIDYDRIMLGKILEDFKGNALAEIDEPVTTDIHRLIRFPYSLHGKTGLMVKPVAIDKLKTFNPLDEAIPDMFLKRDAKINLKIDKFSIEMNGQNYNIARGENSVPLYLAIFASAIDVADFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2T1</accession>
    <name>A0A1V0N2T1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0541</name>
        <name evidence="8" type="ORF">HLB00_02525</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000080">
        <property type="protein sequence ID" value="NOL59709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143140.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2T1"/>
    <dbReference type="STRING" id="74969.FAD_0541"/>
    <dbReference type="GeneID" id="84217139"/>
    <dbReference type="KEGG" id="fai:FAD_0541"/>
    <dbReference type="OrthoDB" id="6342at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07078">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="496" mass="54078" checksum="691F58A31463DFC8" modified="2017-06-07" version="1">MEKIFGNIIDGIEETGGAKIELKSPVDGSLMGYIIDTDKDTVERAIQSSRAAFNKFYPESTIKSRQELIGKLADIVQEKATIYADLESKNTGKTIRQSTFMDIPLAISHIRYFAETDEFKFQRKITHPEYPGTEGIVQNAPMGVVASIAPWNVPFLMAVWKIIPPVLAGNAVVIKPSHYTPLTAIELVKDMKAAGFPDGLVNLVNGTGRTTGNFLVNSDHVDMVSFTGSTPTGSRIMEQAAKNITKVSLELGGKSPNIVFADADLDHAVKGVIFGIFLNAGQLCESASRLIIEESIMDKFLQKVKIYLDSMKSGNPMDFETDISAITTKEQKEKIESLISQTVKSGGNIFYSKNMQGTPDNGTYFPPTLLTGLTPGQQISDEEIFGPVLTVYPFKSEKEAIDLANSTKYGLAAGIWTKDIEKAGRVASMIEAGTVWVNEYHLLSAAAPRGGFKKGGIGRELGLEGILEYTQTRHIFYGNNESGMSDVAYGILIKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2U0</accession>
    <name>A0A1V0N2U0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2U0"/>
    <dbReference type="STRING" id="74969.FAD_0495"/>
    <dbReference type="KEGG" id="fai:FAD_0495"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="TREHALOSE 6-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768:SF3">
        <property type="entry name" value="TREHALOSE 6-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="227" mass="26497" checksum="2D4D6135E8608371" modified="2017-06-07" version="1">MEPQLFLDYDGTLVPIIKNPEINQADYDLLKLISHLDSRFEMYIVTGREVSDIIRFLGEYNIIGLHGSVFHIDGQTINIPEFHKYVELFNQIYQNTVYIQEKFHGLRIYNKTGSILFHMGNIKNQRSRETVHKIINFLAFRYNIELYTGIDIIELRIPHINKGTAIKQIRNLNRPAIIIGDDRTDEDSFIANQDAITIKIGDGDTHARFAIPYERVRPLLWELLKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2U7</accession>
    <name>A0A1V0N2U7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase</fullName>
            <ecNumber evidence="7">1.2.1.103</ecNumber>
            <ecNumber evidence="7">1.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">lysY</name>
        <name evidence="9" type="ORF">FAD_0505</name>
        <name evidence="10" type="ORF">HLB00_00475</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in both the arginine and lysine biosynthetic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + phosphate + NADP(+) = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9712"/>
            <dbReference type="Rhea" id="RHEA-COMP:9714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78499"/>
            <dbReference type="ChEBI" id="CHEBI:78501"/>
            <dbReference type="EC" id="1.2.1.103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + phosphate + NADP(+) = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52668"/>
            <dbReference type="Rhea" id="RHEA-COMP:13313"/>
            <dbReference type="Rhea" id="RHEA-COMP:13327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:136717"/>
            <dbReference type="ChEBI" id="CHEBI:136761"/>
            <dbReference type="EC" id="1.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.103" evidence="7"/>
    <dbReference type="EC" id="1.2.1.106" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000013">
        <property type="protein sequence ID" value="NOL59314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887563.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2U7"/>
    <dbReference type="STRING" id="74969.FAD_0505"/>
    <dbReference type="GeneID" id="16025709"/>
    <dbReference type="KEGG" id="fai:FAD_0505"/>
    <dbReference type="OrthoDB" id="372053at2157"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00037"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17895">
        <property type="entry name" value="AGPR_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02083">
        <property type="entry name" value="LysY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050085">
        <property type="entry name" value="AGPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037535">
        <property type="entry name" value="LysY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338:SF11">
        <property type="entry name" value="[LYSW]-L-2-AMINOADIPATE_[LYSW]-L-GLUTAMATE PHOSPHATE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="347" mass="38496" checksum="9771C95370C2E2B2" modified="2017-06-07" version="1">MKVGIVGASGYVGGELMRLLVRHPEIEITSVSSTRHSGEKVSRIHPDLYGLTDLKFEDITPLDMAGKVDLIFLALPHGTSIKYVPGLVETGVKIIDMSADFRLKNPELYKPWYGYEHGYPDLIKKFVYGMPELHREQIKNATYIATPGCIASSSIYSIAPFLSLELSSDIINVDAKVGSSGSGSGLDESKVFSERFDSIRAYKPVNHRHTPEIEQELEYASGKKVKIALSAHSVNMVRGILTTSSIYSEGDEITLWSLLRKFYGNEKFIRLIMDRKSNYKYPDPKTVIGSNFADIGFAIDKYVKRVVSFGAIDNLIKGAAGNAVQSMNIMNGFNEYEGLMMPSLFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2X3</accession>
    <name>A0A1V0N2X3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl24e</name>
        <name evidence="7" type="ORF">FAD_0591</name>
        <name evidence="8" type="ORF">HLB00_04955</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000168">
        <property type="protein sequence ID" value="NOL60185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841727.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2X3"/>
    <dbReference type="STRING" id="74969.FAD_0591"/>
    <dbReference type="GeneID" id="32192147"/>
    <dbReference type="KEGG" id="fai:FAD_0591"/>
    <dbReference type="OrthoDB" id="55506at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00773">
        <property type="entry name" value="Ribosomal_eL24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055345">
        <property type="entry name" value="Ribosomal_eL24-rel_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF034186">
        <property type="entry name" value="PRK14891.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="65" mass="7746" checksum="680A3732736DAE04" modified="2017-06-07" version="1">MENRKCIFCGHDIEPASGIIYIRKDGNIMNFCSKKCRVNMIDLKRAARNVKWTNEYHRIKEMRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N305</accession>
    <name>A0A1V0N305_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940604.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N305"/>
    <dbReference type="STRING" id="74969.FAD_0621"/>
    <dbReference type="GeneID" id="31676126"/>
    <dbReference type="KEGG" id="fai:FAD_0621"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="1">
        <location>
            <begin position="120"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="369" mass="41593" checksum="E1CF543E21AB0AD2" modified="2017-06-07" version="1">MVVSHWIELNVGPVHPSTHGIYRFRVKLNEETVEDVDITIGYLHRNAEKICELSYYANNTIYFDRMDYIDAMNMELAYLRAAETLMGMEVPERAQWIRMIMAELSRIAARMVGIGALGLDLGMLTPFFHTFHEREKIQNIFVEASGGRQEVNYMSIGGVYQDFNDTIIEEIKEFISGFKGKLEEIVKMYLDSEVFWQRNQGTGILEPEVALDYGVTGPMLRASGIAYDVRKDSPYLFYDNVNFDVPVTNTKDNLGRFLLKAEELRQSIKIIEQCLAKLPDGPFFNPKAKKSAMLLLKGQGDVFTRVESESGEYGVFIRGDGGLKPYRIHARSPSFKNLAVVPVMARGGLIADLIATIASTDAVAGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N312</accession>
    <name>A0A1V0N312_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="4">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="4">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="4">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">uppS</name>
        <name evidence="5" type="ORF">FAD_0573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = tri-trans,hepta-cis-undecaprenyl diphosphate + 7 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887630.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N312"/>
    <dbReference type="STRING" id="74969.FAD_0573"/>
    <dbReference type="GeneID" id="16025780"/>
    <dbReference type="GeneID" id="31676077"/>
    <dbReference type="KEGG" id="fai:FAD_0573"/>
    <dbReference type="OrthoDB" id="8293at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000003">
        <property type="entry name" value="Isoprenyl transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="258" mass="29848" checksum="B522803B03282B60" modified="2017-06-07" version="1">MSIAHKIGDIASGVYEQALMEEIRKADVPLHLGIITDGNRRYAREAGLTPNEGHVRGKDKLEEVLDWAMEVGIRIVTVYGFSSENFKRDPEEVNFLFDLINDSLRGLLKDDRIFKNQIRVRIIGDFKGLPEYLVNTIHDVEKITAGFKKFKFNIAIGYGGRQEIIDAVKNIAADVVSKKLKIEDINEKLFRNYLYDNTLTDPDLILRTSGEERISNFLLWQSAYSELYFSDVNWPDLKKLDFLRAIYSYQSRKRRYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N382</accession>
    <name>A0A1V0N382_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_0691</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N382"/>
    <dbReference type="STRING" id="74969.FAD_0691"/>
    <dbReference type="KEGG" id="fai:FAD_0691"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07562">
        <property type="entry name" value="Peptidase_S41_TRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.44">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.60">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029414">
        <property type="entry name" value="Tricorn_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="TRICORN PROTEASE HOMOLOG 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253:SF1">
        <property type="entry name" value="TRICORN PROTEASE HOMOLOG 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14685">
        <property type="entry name" value="PDZ_Tricorn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26550">
        <property type="entry name" value="Tricorn_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26549">
        <property type="entry name" value="Tricorn_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="717"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="926"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer; via amide nitrogen" evidence="9">
        <location>
            <position position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1029" mass="118826" checksum="A5FC59573F1CD781" modified="2017-06-07" version="1">MYNLYMERYFMYPDINDDLVVFVNDNDLWKYNINTKHIERLTNNLGIVTNPKISPDKKYVYFRLMTGKSGESSDIYSIDLEKGNLNRVTYLCGKSTSRRMYTSIAGFDKNGNLIISTDAYYPFGTPMLYRIVNENTEPLNLGPALNIIYYGDYTIIGRNTIDMPHWKRYKGGTRGKILSCKNDDFKIIIDLESNVNSPMIYNDELYFISDHEGSANIYSADFNGGNLKKHTDFKDYYVRNANSDSKKIIFQKSGSLFIFQNDRVEKLDININIPSVNIENRIVKATDYLTDYKINYTGNLIGLISRGQALFTGIKNGPVMNINKLKNQIIEFMNNNDIIIYNYNEENNKILLYSVDKTLKKFFDFKNGIIFSMKASPDSKYIAIGNNRFELFILNVENGNINKIDESESGTIDDFSWSNDSILLAYSYPESEYYGYNESASIKIFDLTANKKYDATTSGAIDFKPVFSNDDNYLFYLSKRSLDPVADQLVFNLGYPKITKPYAIPVKENIFPLFSDIPEELHENIPGKYKLNNIIQLSEVFPVPAEDYANIIPVNNGVLLLHYPVEGSMKYYLFNNDEKTGNIELFDFKKKKSELYESEVVNYLISGNKKFLLIRKSSNKFIEREIEPKKDEDIDLTRLNITIEPMNEWKNMLYDTFNLIKENYWSKEKVEKLGDDPYLKYKKLLNKVRTRFELSDLIREMQGEYSTSHSYEIGGDLSNVESISIGKLGIDYEFKNNNYIITKIYNGDPSNENEKSPLLYTGIKENDIIKSINGVTLDATNNPDKLLLGHANEIITIEIVNRNETKKYYVKTMIDEKYLRYREFVERNRKYVHEKTGDKIGYIHIPDMGMNGFNEFFRIYDREANRSGLIVDLRFNGGGFVSQLLLEKLSRKRIGYDVPRRGIITPYPIDSVNGPMIGLTNEYAGSDGDIGTHVFKLMGLGKVIGTRTWGGVVGINPKIKLLDNTTVTQPQFATWFKDVKYGMENYGTEPDIYIENMPQDFLKSRDVQLDSAIEYILKEMNDYKKLDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3A2</accession>
    <name>A0A1V0N3A2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">deoD</name>
        <name evidence="2" type="ORF">FAD_0727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141852.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3A2"/>
    <dbReference type="STRING" id="74969.FAD_0727"/>
    <dbReference type="GeneID" id="31676229"/>
    <dbReference type="KEGG" id="fai:FAD_0727"/>
    <dbReference type="OrthoDB" id="372263at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09005">
        <property type="entry name" value="NP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="233" mass="25218" checksum="F864DD241FE91C03" modified="2017-06-07" version="1">MAIIKAEKGQISDKVVILGNLDRQKIINSYLKNTEKVSEFAGYHTYTGEYNGKKITTVFHGIGIPSMALVVDDLIGMGAKQIVRFGSSFSVSDKVKPGTSILPIGYSYNFGGVFKQYLGDEYSIALTPDYGMLKAEEEKLSAAGLGPVVGNVFTSDALMTHNKEFAQKLAKDGNIAVELEGAGLYFIAKLRGVKALSVHLAYGNLVTGEQLPADKISENEKKISETLLELLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3B0</accession>
    <name>A0A1V0N3B0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3B0"/>
    <dbReference type="STRING" id="74969.FAD_0739"/>
    <dbReference type="KEGG" id="fai:FAD_0739"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="294" mass="34373" checksum="D02F91E6291F9038" modified="2017-06-07" version="1">MEIIDNIVSPDDRKRKYTDRQILKVLIVLQIFNISYRSARIFLTSHEKYLRMIGIKEIPSFQTLSRRARMIDLHAVNNDIASLYSIESIAAIDSFMIHTCKHSTAIRRKIWGNYKDPVSGWSKTTKGWSYGRKCHMAIDVDSLIIMDWMVTKGNMHDSHVSHDIVDSVRDFSYVLADSAYDASDIYDYVFENTHALPVIDTNKRRGIVDNRLPLNRKIGIKLRKEYASMYPLRWEIERTFSILEEILKAEYIWYTVKRDYDTAIGLKTIAYNLMVISNMELGEKPREIMKIVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3C0</accession>
    <name>A0A1V0N3C0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0668</name>
        <name evidence="2" type="ORF">HLB00_07530</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000277">
        <property type="protein sequence ID" value="NOL60678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887734.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3C0"/>
    <dbReference type="STRING" id="74969.FAD_0668"/>
    <dbReference type="GeneID" id="16025885"/>
    <dbReference type="GeneID" id="31676170"/>
    <dbReference type="KEGG" id="fai:FAD_0668"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="88" mass="10088" checksum="79FC07D75D48F000" modified="2017-06-07" version="1">MLIDRNKFGEIQKSAWITPSEFKTKLIENQGKDIKLQLKGEKNRYVTIVRVSQNEVTLSEPGGEVISVPLSNVAGFTTETDWYRQKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3C8</accession>
    <name>A0A1V0N3C8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3C8"/>
    <dbReference type="STRING" id="74969.FAD_0667"/>
    <dbReference type="KEGG" id="fai:FAD_0667"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="346" mass="38102" checksum="4E4D9CFF89EED7F0" modified="2017-06-07" version="1">MYIYSCVNFVVNKKRVITGVLMAAVFVMIAFVPATDNMHTAQNNTATNNILPQFEMNASTINNINSRFAQNNFENRNLNWKPVNLSKSSLLNRSSIKNFTEKYAVINNQIYLQLTINNSKMPRGARNQNTTLVGANYIEYIETTDNSLNIKSIIYRENVNKNIGNKSVYIINGKNAKLISVDPETYHQSYGWGNAWVFYASDTFQGPIGTGDFTNLMTLIGGVTGLAVGAVFAASAAIAAVAGILGAVVAFSWASFVNLHTTSQDTTVPYVEIAVSEGYWWDFWDTGAYGELGAHSNQAYNFNGQLVYSGGWLYFPFLTTEPLGTGLQITSLAPHASVWPSVSPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3K8</accession>
    <name>A0A1V0N3K8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Plant-type L-asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd04703">
        <property type="entry name" value="Asparaginase_2_like_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
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    <dbReference type="PANTHER" id="PTHR10188:SF13">
        <property type="entry name" value="ISOASPARTYL PEPTIDASE_L-ASPARAGINASE 2-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
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        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="site" description="Cleavage; by autolysis" evidence="4">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="272" mass="29451" checksum="1013424681BC2D9F" modified="2017-06-07" version="1">MKNQIVIHGGANSPSTLNEKLQKILDNLDVNGSSLDLAVKSVVMMEDDPTFNAGTGSVPRIDGSIQMDAAVMSDSGFGSVMCIENVKHPVMVARDVMEKSPHIMLAGEGAVEFARKLEYEYYNPETEKSREMMDKLKASIKNNTLPEKFKFMVKSSSDTVGAVARIDDKFAAAVSTGGAFPMLRGRVGDSPVIGAGIYQGEKGAVVATGIGEDIAKDLLSFRIYQQIGTDDLNEIVKKEIDKFKVSVGIIAISDNEYSVYANTDMAHAEREL</sequence>
</entry>
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        <name type="scientific">Ferroplasma acidiphilum</name>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052962">
        <property type="entry name" value="AA_Transporter_AGT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47547">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47547:SF1">
        <property type="entry name" value="ASPARTATE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="114"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="211"/>
            <end position="229"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="249"/>
            <end position="267"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ARD84705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="599" mass="64909" checksum="81316953EEE9D79F" modified="2017-06-07" version="1">MNNTIADICLAVTGKILYYVFPYFQMRDTDSLHSGSISNDKKLKKVLTSWDLYFLSLGAIIGSGWLFAESAAAGTAGPAAILSWIIGGAIVLVLVLVYAEIGAMIPRSGFITRYGHYSHGGIAGLFFGWGYFAARVAAPALEAEAAITYAGSYITKPALIYYAKNPLDPSSSVTLLSGYGILIAAALIAGFYFLNYFGVKLMGKTNQGITWWKLIIPSITIILMVFLLFHAGNFNNPALGGFLPHNNISLVFEAISTDGIVFSYLGFRHTLNFAGEAKNPQRDIPRALIYAMLTSIVVYVLLQFAFISAINPSLLTASGGWLGLSSASAGTYAKSIDSAPFAFLAKSSSLAILAVLTYLLYADAYISPAGTLNIAAGTATRSLYGLAEIGYFPRTFGKVSKRTGVPVFSLLISLVLGLIFLVPLPSWYVVVGLVSGVAGFTYILGGSTLMVLRREASDLKRPFKLPYARILSPVAFIGASLIVYWTGWPTVAYIAIILFAGFAVYLVFLAFHHVDNIFTKENIQGGYWVPLLIIALTILSYLGESNFGGINLFPFPYDFLVVMVVSLIFYFLSVKSGFRTSEITDMIESGEQYIDEYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3T1</accession>
    <name>A0A1V0N3T1_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Glycosyltransferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoplasmatota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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    </dbReference>
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    <dbReference type="STRING" id="74969.FAD_0870"/>
    <dbReference type="GeneID" id="31676373"/>
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    <dbReference type="OrthoDB" id="132546at2157"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="186"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="356" mass="41938" checksum="2BDD8A92FB694FDC" modified="2017-06-07" version="1">MKVLLIDEFSRIGGGQILSKLLLDYFNKNYGQTYLAVDREHTHIEYENIIQTPYYFRENMKLPSLYYYVAKTKKFLKHYIDNQFDLVFNNHPNMFLYKADINALHGFSFLDQIIDEYGNIKNKIIFNFIKKSGMYNLYNNANFYVNSNYTLKISNKLFPLLNIKPGIMKVIYIPVGYKEKPDLAFKVKNLVISIGRIDIRKNYGELFKIAVKLKNYRFIIAGALNRGDEEYYKNLIQNKPDNVEIKVNINEHDKLELLKKASIYIHLNRKEHYGISILEAMSYGIIPVVPESGGPWEDIIEHGKYGYGFNSIDEAVDQIKNIDFDIVKTIMDLMYRFSFKNFYYNMDNFVEEVQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3U4</accession>
    <name>A0A1V0N3U4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0847</name>
        <name evidence="2" type="ORF">HLB00_09590</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000425">
        <property type="protein sequence ID" value="NOL61069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887967.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3U4"/>
    <dbReference type="STRING" id="74969.FAD_0847"/>
    <dbReference type="GeneID" id="16026078"/>
    <dbReference type="GeneID" id="31676347"/>
    <dbReference type="KEGG" id="fai:FAD_0847"/>
    <dbReference type="OrthoDB" id="375422at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL61069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="217" mass="25447" checksum="EF652756AA9A8936" modified="2017-06-07" version="1">MQQSGKKPKVTKRGNIKNDVINILNENKAFKWMLNTGVVNYNSLSRIIQNQIKEKYNYTPKINTISTILRKDYDATRQKTTNNPFSDMKINIITGLSLLYCDYDDEAMRAYYPYSRAIRITPESHTMWVMISGETPENIKKTYPEKLYGDFIEINITIDREKINEESIQTFMETLSFNYINVSQLMISNDGFELFISARYLPMVLRLIEAIKSNRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Y6</accession>
    <name>A0A1V0N3Y6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS200-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142271.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Y6"/>
    <dbReference type="STRING" id="74969.FAD_0977"/>
    <dbReference type="GeneID" id="31676476"/>
    <dbReference type="KEGG" id="fai:FAD_0977"/>
    <dbReference type="OrthoDB" id="92826at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="entry name" value="Transposase IS200-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033573">
        <property type="entry name" value="transpos_IS200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33360">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33360:SF2">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="Transposase IS200-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS200-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="133" mass="16075" checksum="D4B267351B99AE3F" modified="2017-06-07" version="1">MVSERWTRSNKSVYNLGYHIIWCPKYRRNVLVNGIDVRLKELLNYKAQELKIEIKEMEVMPDHIHIFLKADPVLSPHYIIQQFKGYTSRILRQEFPVLKRKLPTLWTRSYYIESVGHISEQIVRKYLEDQKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N402</accession>
    <name>A0A1V0N402_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine/organocation superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142177.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N402"/>
    <dbReference type="STRING" id="74969.FAD_0914"/>
    <dbReference type="GeneID" id="31676417"/>
    <dbReference type="KEGG" id="fai:FAD_0914"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="477" mass="52227" checksum="2EDDA2152F19D677" modified="2017-06-07" version="1">MDNALNRNSMTFWGLVFYAIMVIAPAGPFAFTGASAMEYAGKTAPLTFLIGGAILFLAVIAVYIYSEKVSNAGGYYKYVEVATHNKYLSKSVGFYYLFMVLSSIIGSSILLGWFLYIGLEVMVGYTLPFVFVVLVSFITSVIYLVVGILALNYSQKIAIVVGLFDLAFFLTLSAAIVIKSPYNGIQYFNIFNSTNGFHGFFLGMVTGGFVAFSGYGSIVVLAEETKTPGKTIKKAIVTSLLIMIAYDTFIIYANVGGLGPNLPAGLAYFAPGLYVTDSYYGIYITLLAFSVFLVSALISTVIFGNSAARDLYSLARDGILPKTFTKIHKEYRSPYMAVIAVFVVAVVGISLGLVPLVYYYGENNGLFDLLVINSIIGSVFTLSYHIIVNETLPVLMHRLKQLNPVTHIIAPTAASVMIGIAIYYSLIDLVWSLSAAYIFLPGLIILAIIITYSRKNKVQMDTIEQEDSERKARRTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N422</accession>
    <name>A0A1V0N422_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951125.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N422"/>
    <dbReference type="STRING" id="74969.FAD_0951"/>
    <dbReference type="GeneID" id="42785072"/>
    <dbReference type="KEGG" id="fai:FAD_0951"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="53" mass="6565" checksum="F028798B0C34E9D3" modified="2017-06-07" version="1">MNNESKREEPRDIITFGINRTAILYNKELLSDPIKYDFQYQSDHLLFQRRRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N424</accession>
    <name>A0A1V0N424_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type peptide/opine/nickel family transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N424"/>
    <dbReference type="STRING" id="74969.FAD_1017"/>
    <dbReference type="KEGG" id="fai:FAD_1017"/>
    <dbReference type="OrthoDB" id="57555at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="172" mass="19105" checksum="B4A60F580CF80229" modified="2017-06-07" version="1">MGVIALVIPLIAFIAALIIPGILILDYVHVLFGALWTGVDVFLGLIFFIVLSGMEDRIRSDISFRLIPMLLYFIPAMSVFTPLLGFALAMRENIFRLDYLFIAIITISIALAVVSFAVIVPAIYSIYKGFKSNNVDESRNGKLLMRIAKAASLQMVLQIIIISLMAYIVVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N430</accession>
    <name>A0A1V0N430_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Acetate--CoA ligase</fullName>
            <ecNumber evidence="2 6">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142356.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N430"/>
    <dbReference type="STRING" id="74969.FAD_1022"/>
    <dbReference type="GeneID" id="31676521"/>
    <dbReference type="KEGG" id="fai:FAD_1022"/>
    <dbReference type="OrthoDB" id="371752at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043955">
        <property type="term" value="F:3-hydroxypropionyl-CoA synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043427">
        <property type="term" value="P:carbon fixation by 3-hydroxypropionate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="79"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="520"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR02188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="639" mass="72613" checksum="C4977E31CBDF451E" modified="2017-06-07" version="1">MKDTLPMDEKYKVHMSKYFEEYERSLKDVNGFWNENGRIIDWFKPFDKVLDDSKKPFYRWFINGKTNLSYNCLDRHIQNEKRNKVAFIWVPERGEEKVVTYFGLYRRVNAFARGLLNLGVKKGDKITIYMPMILEAPIAMLACARIGAVFNVVFSGFGEQALAERINNSNSKTIITADGGYRKGNIIQLKNIVDKAIDLSNGVDNVIVVKNTHTEIDMEPDRDYYYDDIIEDGYVEPEQMDSNDPLFILYTSGTTGKPKGILHANGGYPVWIANTLKWAFNPKDEDRWWCAADIGWITGHSYIVFAPLLLGLTSVMYEGAIDYPKPDRMWEIIERYGVNLLYTSPTAIRLLMKYGEKYPLSHDLSSLKTLGTVGEPINPAAWHWYYEVIGKSRCPIIDTYWQTETGGFTISPSARLGLPDLKPGSATFPMPGIDAEILDENGKNVKPGEKGYIVIKKPWPGLMLTVNNDDKRYIDTYFSKFKGKYFMGDYAIQDDDGYYWLLGRSDEVLKVSGHRIGTIEVEDGLVSMKEIAEAAVFGKPDTVKGDTIVAFATLKDGYEKSPELIENIKKRIRNNLGPIMVPEEIHIVSTVPKTRSGKIMRRVIKAVYLDQLPGDISTLENEASVEEIKRAVDIIKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N436</accession>
    <name>A0A1V0N436_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VapB-type antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142301.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N436"/>
    <dbReference type="STRING" id="74969.FAD_0993"/>
    <dbReference type="GeneID" id="31676492"/>
    <dbReference type="KEGG" id="fai:FAD_0993"/>
    <dbReference type="OrthoDB" id="30861at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052975">
        <property type="entry name" value="Repressor-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34860">
        <property type="entry name" value="REPRESSOR-LIKE PROTEIN SSO7C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34860:SF6">
        <property type="entry name" value="REPRESSOR-LIKE PROTEIN SSO7C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="AbrB/MazE/MraZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="80" mass="9190" checksum="DB5F3DC76326D869" modified="2017-06-07" version="1">MEEVKITRNYQTTIPADIRDKLGIKIGDRILVYIDKDRIIMEKPKGDITKISIKLDKNIDAEYVEKVIREAGDEIGRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N443</accession>
    <name>A0A1V0N443_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF998 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142395.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N443"/>
    <dbReference type="GeneID" id="84217634"/>
    <dbReference type="KEGG" id="fai:FAD_1037"/>
    <dbReference type="OrthoDB" id="46160at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20364" checksum="03D2131001CC511A" modified="2017-06-07" version="1">MKISDKTAMKISGLVLFAGAAQFFLLVLIAEALYPHYSVANNYISDLGVGSTAYIFNTSIVLLGIAIIISAAFLLKFSKPLRIVLILAGIGAMGVGIFPETTGAIHLYSSLLVFFMASIATYFILWRLKNIISVFWAILGTIALIALVLYATGIYLGLGVGGMERLIVYPDILWALGFGGWIVAKYGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N444</accession>
    <name>A0A1V0N444_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="3">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142283.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N444"/>
    <dbReference type="STRING" id="74969.FAD_0984"/>
    <dbReference type="GeneID" id="31676483"/>
    <dbReference type="KEGG" id="fai:FAD_0984"/>
    <dbReference type="OrthoDB" id="57329at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="7">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="239"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="425" mass="47110" checksum="8F0DD19CBFE6F75B" modified="2017-06-07" version="1">MDPIHTSITEYNDSIFVINVPRIKFGVNSTKETGYEAKSLNIKNAMVFAGKKLSESRQMETLINSLNENNINYKIIDEIRVEPEDTAWLDTYKKIKDEKIDGFISLGGGSTIDTAKIMDLLYTYKGNLEDYINKPIGKGISPPGPLKPHIAIPTTAGTGSETTNVAIFDVTKIKVKTGISNPYLRPTIAIIDPVNTYSLPQSVTASSGLDVLNHAIESYTAIPYTGRQKVNPGDRPVYTGNTPIGDLFAKEAIKWVHTYMKRAYSDPYDSEARYYMMLGSSIAGMGFGHVGVHIPHAMGYPIAGMIKEWHPDDYDFGYPIVPHGIGTAIPAAYVFRYLSKYSDRFKDISSILGIESGDTGDALFEYYIKLLKALKIPTNLSDIGFSDKNVEDLVNGTLKQQRLISLSPKMLDKKELTEIFKECIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N478</accession>
    <name>A0A1V0N478_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142330.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N478"/>
    <dbReference type="STRING" id="74969.FAD_1008"/>
    <dbReference type="GeneID" id="31676507"/>
    <dbReference type="KEGG" id="fai:FAD_1008"/>
    <dbReference type="OrthoDB" id="56465at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051012">
        <property type="entry name" value="CellSynth/LPSAsmb/PSIAsmb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45586:SF1">
        <property type="entry name" value="LIPOPOLYSACCHARIDE ASSEMBLY PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45586">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN PA4667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="516" mass="59465" checksum="EB5C5DDB8E49D4D0" modified="2017-06-07" version="1">MFRTDNKNVYELTEKAQKLFEAGDFAGSLETINRAISILPRNVDLHDFKSDILFHSGDFEETIKELEFIETLDPGDASHYSMESLCYLQMGDDEKALDLADKAIKVDKDYEFSYYNRARALNNLGRTEDAISAYKLSLEKNPSDPDGHRDLAELYLDAGNYKMAERELKLSLRFRKNDKITNDLMVELKLATGGAFEFTKALLDAFKNTADTDYLVRITDFLLDNGDMDNAEKIAKDFYNSALDNLDMASNLAKVYYIEQKYDMGNRIFKEYIKRNNNIEANEEYIKMLVTTAQYDLALSIIEENARKYPEEETFIFYKFYALSEKGEHADALLPIKTLYDKQPDSVQYGINYAIELSHNGVKDEPVDILNRISKLDKGPEIERAYYTVYGNLGLYDKAVEYLGRAVEMDDDIEEICDILNPAIEDSITKNYHEKIIQLLNTLPDKEENIIHALYAIEKACILSAVNRTEEATKILEGIDSKEDVCMIINQYMDFENSRISEFLEDYFNKHCNNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N483</accession>
    <name>A0A1V0N483_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142430.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N483"/>
    <dbReference type="STRING" id="74969.FAD_1062"/>
    <dbReference type="GeneID" id="31676561"/>
    <dbReference type="KEGG" id="fai:FAD_1062"/>
    <dbReference type="OrthoDB" id="9014at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="309" mass="34041" checksum="16B681D580B73673" modified="2017-06-07" version="1">MAKINIENGNKPYNTESDLSSVFGQDDQRGNLNLIDNIKVMKSLKIPETGKVYRMSHTIYNGMADRPTHGPYFFDIMLRPYDNGFTEKYANKYGPSLGRLEMCDHTGTHFDALSHMAYDGKFFNNIPVNDVITNTGYKKLGVENAGPIITGGIMVDAAAASGTDILEGGYPITVQEVKKFLKDNSITPEPGDAMFFHTGASSKFSNPGKYDKFYDSSAGIGYELARYLNELKISVTGSDTPSSEVVPPEDRNTRLPVHQYLIAKAGIHIIDNLSLHRMAKDRAYRFLFVCSPIPFMGATASPVSPVAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4A0</accession>
    <name>A0A1V0N4A0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4A0"/>
    <dbReference type="STRING" id="74969.FAD_1045"/>
    <dbReference type="KEGG" id="fai:FAD_1045"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="460" mass="49311" checksum="FDFAE0825FBE48C5" modified="2017-06-07" version="1">MILYFTTIPDSTSWLNTGNNGWMLTASTLVGLMSIPGLAIYYAGLTKRKYMVNAMMMALYAFAAVLIIWILAGYNFGFGTSSLLKIDGYYIFGIPSPAGAGSFISGQAIVGPLKDALTIPNSTVMFFQFVFAAITPILLLGGILERMNFKAWMIFVPIWSLVVYSPVAYWLFAGGWLNQLGAVDFSGGYVIHLDAGIGALAAAFVIGPRLKDEMKMKANNLGLVMLGLGLIWLGWDGFNGGDPYGATIDAGIAIINTNVATAVSMMTWMFMDLKFFKKPSLIGASVGAIAGLVGITPAAGYVNIYGAMVIGIATGIIPWIFLYKIEPKFKVDDSLGVFSSHAVAGVVGGLLTGVLADPVVTQYIDPGLRGALYGNFYELGIQAFAAVIVILYVFALTYGLLRLIGVFIPLRETNARLKIGDMAIHGEAGLDITGYPPSPPMHAIEHNNIHMEGNEKIDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4A2</accession>
    <name>A0A1V0N4A2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4A2"/>
    <dbReference type="GeneID" id="16024273"/>
    <dbReference type="GeneID" id="31676552"/>
    <dbReference type="KEGG" id="fai:FAD_1053"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="153" mass="18273" checksum="252575943F918064" modified="2017-06-07" version="1">MDQLLENVKIKMKNSNYLSSIKEKLLDYSEIIKKLYQFSLYKSYEDININYYGYKLYIDFDFKPDVQIKFVQHIHTNNSADVFFEFMKYEDVKLERKAKNAVAADELINRQFNNVKSSTLVFNLTINEVDIIIISDKQYETVLEKDCDFQIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4C3</accession>
    <name>A0A1V0N4C3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4C3"/>
    <dbReference type="STRING" id="74969.FAD_1074"/>
    <dbReference type="KEGG" id="fai:FAD_1074"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="49" mass="5383" checksum="0CD60F272BF86E7F" modified="2017-06-07" version="1">MPLIVKSIINLSQYMIESGMSLNDDIKPHDSGNHTLTEYIIAAGEDHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4C6</accession>
    <name>A0A1V0N4C6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4C6"/>
    <dbReference type="STRING" id="74969.FAD_1073"/>
    <dbReference type="GeneID" id="84217673"/>
    <dbReference type="KEGG" id="fai:FAD_1073"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="23"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="476" mass="52063" checksum="DC25D57F8D19409E" modified="2017-06-07" version="1">MDNNEPVLESKFQLKKGAVGKWHAVFQAYTHVAPSGDIGILLTGVALFALGASPLAVLLSWVIYLLMVNTNYRFSQRVSHAGGYYAIGGHGMGGFYGFMNGWIYLLDEMIIYPSFGLLGFASVIFLLSPAISSIPFIWVPLILIPFATGLLFNYFGIKPSLVYLLITATVEVIFLLSTSWYIIFTMGPANTLSVFSLSGINVIPFIFALLYGIEAYGGLGTVIGISEETKQSKFNIPRAIIIAAILAGATLISAMYALTIAWGPTSMTSYATSPDPGLIIWHRFFGLPGEIILLFFILNGYIAYTVANPIVQSRVIYAMARDGVFPRWFAVTHKKYKTPYRAVILVSIIALIVSMGLSFPFGPFDAAIITGAMAGIGLVSAHAMSSLAYIRYARKDNKIKYSIVKDAIIPVASLIILIPIIAFAFDELTWPYILSPILAGLWVLGAFIFGLYLYKNKRKDLENAGSEDFSEVITTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4G0</accession>
    <name>A0A1V0N4G0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142481.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4G0"/>
    <dbReference type="STRING" id="74969.FAD_1110"/>
    <dbReference type="GeneID" id="84217708"/>
    <dbReference type="KEGG" id="fai:FAD_1110"/>
    <dbReference type="OrthoDB" id="372263at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="228" mass="25787" checksum="9BA2B919B65A2A0C" modified="2017-06-07" version="1">MVFKSKKGDIAGNALVVANVDRFNMVKNKLSDIKLVNDFMGYYTYTGFYENKRLTLSWSGIGNTSLALDTLELYKLGAKNIIRFGSTASINKNIKPGSYVMPISYSHNNGGLFNEEIKDNLSISLSADYDLLKKFDLNLKDYEHYITDAFTTDSQKVRTNEFIDKLNKLGIDNLDMEGSALYLNSKLYNFKALSVLTVYSNLITGESLSLEEIREKEEILFKIIVDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4G1</accession>
    <name>A0A1V0N4G1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Citrate synthase</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1100</name>
        <name evidence="7" type="ORF">HLB00_00905</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000025">
        <property type="protein sequence ID" value="NOL59398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886204.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4G1"/>
    <dbReference type="STRING" id="74969.FAD_1100"/>
    <dbReference type="GeneID" id="16024329"/>
    <dbReference type="KEGG" id="fai:FAD_1100"/>
    <dbReference type="OrthoDB" id="21302at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06118">
        <property type="entry name" value="citrate_synt_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054926">
        <property type="entry name" value="Cit_synThplmales"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041157">
        <property type="entry name" value="Cit_synThplmales"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010640">
        <property type="entry name" value="PRK14037.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF4">
        <property type="entry name" value="CITRATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="372" mass="41569" checksum="67C83E5801D4D3AF" modified="2017-06-07" version="1">MEEISPGLENVYIKYTELTFIDGQKGIMRYRGYDINELAEKSSFEKVSYLMLFGKFPDDSELKNFQNKINSHLALDDYLKDILRAMPETSDSLGILQTLLSAKASKESNYKYTKENDGEKIPEILGSVLSMVANIYRLKSGNNIIDPEPGESYAETFLKACSGSADKNKISAMDSALILYMDHEIPASTTAALVTASTLSDMYSSLASAIAALRGPLHGGAAEGAYRQFLEIGEPENVNAWFENNILNGKRRLVGFGHRVYRTYDPRLKTFKKYADILSTTEEQKKILAIAKRLEEAGVKAFGSKGIYTNTDFYAGMVFNAIGFPVDMFTTLFGLSRISGILAHITEYVETQERLIRPRAIYRGSGERKYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4G7</accession>
    <name>A0A1V0N4G7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4G7"/>
    <dbReference type="STRING" id="74969.FAD_1152"/>
    <dbReference type="KEGG" id="fai:FAD_1152"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05403">
        <property type="entry name" value="NT_KNTase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="52" mass="5809" checksum="57B47532A417D398" modified="2017-06-07" version="1">MLTILIGSLARGDCTPFSDADVIIITDSTRSEIEFMDPHMPIDIEPRVFTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4M1</accession>
    <name>A0A1V0N4M1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886282.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4M1"/>
    <dbReference type="STRING" id="74969.FAD_1180"/>
    <dbReference type="GeneID" id="16024408"/>
    <dbReference type="KEGG" id="fai:FAD_1180"/>
    <dbReference type="OrthoDB" id="55856at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd22231">
        <property type="entry name" value="RHH_NikR_HicB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="125" mass="14519" checksum="9EF979D75AED5403" modified="2017-06-07" version="1">MTEKSEKLTIRISNDELEEIDSFLSYNSNYASRSEFIRMAVLEYISIKRIGIITKNNSIHPDPLIEKAISKMVSAGFYKSIDDAYEEIIKEAWRQNLISGMLKATGDEFSKIEKILEEEKRYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4S8</accession>
    <name>A0A1V0N4S8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1274</name>
        <name evidence="2" type="ORF">HLB00_03235</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000103">
        <property type="protein sequence ID" value="NOL59847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142737.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4S8"/>
    <dbReference type="STRING" id="74969.FAD_1274"/>
    <dbReference type="GeneID" id="84217869"/>
    <dbReference type="KEGG" id="fai:FAD_1274"/>
    <dbReference type="OrthoDB" id="57301at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="121" mass="13657" checksum="FA6332290C09ABC2" modified="2017-06-07" version="1">MIKMEDIVTIAKMDSEKRKETMMKLFSDMFKEDDSKKVEMMKNLITAMNKTDDATYIGLCTTNISIASGMEDDELKAFVALRMKANSELPADIRTRDLNMIQSAMGKVPSSVSQRLAKFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4U0</accession>
    <name>A0A1V0N4U0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142739.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4U0"/>
    <dbReference type="GeneID" id="84217870"/>
    <dbReference type="KEGG" id="fai:FAD_1275"/>
    <dbReference type="OrthoDB" id="157520at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14797">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="entry name" value="TT1751-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38342:SF2">
        <property type="entry name" value="INNER MEMBRANE OR EXPORTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38342">
        <property type="entry name" value="SLR5037 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="TT1751-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="125" mass="14321" checksum="B36D8AD0D9DBB2D5" modified="2017-06-07" version="1">MFLKYKSVHTFEETVKLATDFIKSKGITVFSIVDHRKNADNAGLEMQNETLILFGSPVVGTLLMKENPEIGIELPSKLLIYSTNSDVYILYKDPEEFLKVYAIRESTDAIEKLKMLYKQIVEQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4W7</accession>
    <name>A0A1V0N4W7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142743.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4W7"/>
    <dbReference type="STRING" id="74969.FAD_1277"/>
    <dbReference type="GeneID" id="31676775"/>
    <dbReference type="KEGG" id="fai:FAD_1277"/>
    <dbReference type="OrthoDB" id="56751at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="249" mass="27538" checksum="32AECABB349CD8AA" modified="2017-06-07" version="1">MPYKTIKTEEENGTGFIYFDREDHLNTITVEMINDISSALSDMESTCRSIVIGGKKNFSAGADVLQFPELDPSEAYEFHRKLNELALYFREYTWPVISFLNGYVFGGGLELSLSTDIRVCSNDAQLSQPEIGLGINAGAGGNVILPHVVGRNRALYMILTGARLNAQTAYEFGLVDILAGNALEEATRLGQIINTKPENTVKLAKRAVNNTSSSHIKTNLDYEAALFGILFSGEETKDRINNFIKKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Y7</accession>
    <name>A0A1V0N4Y7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Y7"/>
    <dbReference type="STRING" id="74969.FAD_1307"/>
    <dbReference type="KEGG" id="fai:FAD_1307"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="78" mass="9185" checksum="A2F5B178AF86507D" modified="2017-06-07" version="1">MNIHIETFKNFPLKLRIIGYILLTDAFANFLTIFMIYTGKLPFKYMIITGINATVLGICAFFFAEYRIKKNMRNRNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Z2</accession>
    <name>A0A1V0N4Z2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoin/pyruvate dehydrogenase complex, E2 component, dihydrolipoamide succinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Z2"/>
    <dbReference type="STRING" id="74969.FAD_1291"/>
    <dbReference type="KEGG" id="fai:FAD_1291"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="71" mass="7805" checksum="C1D57373D993614B" modified="2017-06-07" version="1">MWDVQGLGKAIITQWYVKVGDSIKEDTPVCQIMAGKVTVEVEGKAKGKVTKIFRDINAEIVPGDDLLEVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Z5</accession>
    <name>A0A1V0N4Z5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="3 13">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_1345</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="3 13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142828.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Z5"/>
    <dbReference type="STRING" id="74969.FAD_1345"/>
    <dbReference type="GeneID" id="84217957"/>
    <dbReference type="KEGG" id="fai:FAD_1345"/>
    <dbReference type="OrthoDB" id="8493at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00384">
        <property type="entry name" value="ALAD_PBGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000019">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="322" mass="35930" checksum="0EBFEB8452D867E6" modified="2017-06-07" version="1">MFPVERMRRYRLNSNLRDIFSETKINSDKLIMPVFVDETEKSKTAIKSMPGIYRYSLNEYEKYIGHLEDIGVKNIIIFGIPKHKDSSGTSSYDHDGIVQKAIRSAKLNTKLNVIADLCLCEYTDTGHCGVISNGYVDNDKTLNIYGKEAISYAEAGVDIVAPSGMMDGQVGVIRKAMDSNGYVNTMIMAYSSKFASNLYGPFRDAADSTPQFGDRKSYQMDYRNGDEAMREIDLDVKEGADIIMVKPALFYLDMIYRAKQLYKMPLATYMVSGEYSMVKNAVLSGALAADTVNEALISLFRAGSDLAITYFAEDYIANHGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Z9</accession>
    <name>A0A1V0N4Z9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1358</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142850.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Z9"/>
    <dbReference type="STRING" id="74969.FAD_1358"/>
    <dbReference type="GeneID" id="31676850"/>
    <dbReference type="KEGG" id="fai:FAD_1358"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="130"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="286" mass="33571" checksum="8EA0C60360E3B72B" modified="2017-06-07" version="1">MKIENNKKKIYKLFLLPYLIIGLITVSIFTIFDNFILLHPTKIENIILNIFNIFIYPAELGILLYLYFKKTGYLDEPRNAVKDYDLSEIYTKKYAGIKYRESNIKEINIYIYDLNDLFHLSPAGIFYSKALKILIQRDFLDYITPDEMDAVVLHEIGHFITNSGLIRKVLAFAILLAGGAIIFLLLTIFMYGVQLSLLINLIIGFLTVIIILYSIFTIIFNREELSCDIFSIKELKKDYISTALQKTSYYLSKNIIGHRYMIFRIKKQINKRLKKIEEYNETNKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N552</accession>
    <name>A0A1V0N552_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886505.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N552"/>
    <dbReference type="STRING" id="74969.FAD_1393"/>
    <dbReference type="GeneID" id="16024631"/>
    <dbReference type="GeneID" id="31676885"/>
    <dbReference type="KEGG" id="fai:FAD_1393"/>
    <dbReference type="OrthoDB" id="210900at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="123"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="295" mass="35006" checksum="FF072162FB6AC3F6" modified="2017-06-07" version="1">MKLNNKKIKYIIKQKEKGESSKKLAIIYGVTVRYINKIYFNYLEYGKEELYKTGRKKKNIDSNTEELIINIRDNYPLSGPLPIEKYLKDKGIQISHNIIYRILLKYNMVNEDINKKNQRKYLKYEREHSNSLWHMDWTKYSDSEKLIIIEDDASRFIVGMGIYSEETIDNTIETLEIAIDLYGKPEEILTDHGTQFFSNGKNGIPGDKNKFQEYLDNNNIKHIVGRIDHPQTNGKLERLNYTIKRLRPYFSTWDEVVYYYNYKRRHMSLSIDDRPVVTPAMAYEEKGGKLNVKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N590</accession>
    <name>A0A1V0N590_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic acid:H+ symporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142885.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N590"/>
    <dbReference type="GeneID" id="31676904"/>
    <dbReference type="KEGG" id="fai:FAD_1412"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050189">
        <property type="entry name" value="MFS_Efflux_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124:SF3">
        <property type="entry name" value="CHLORAMPHENICOL EFFLUX PUMP RV0191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124">
        <property type="entry name" value="PURINE EFFLUX PUMP PBUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="29"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N599</accession>
    <name>A0A1V0N599_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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            <taxon>Thermoplasmatales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="74969.FAD_1415"/>
    <dbReference type="GeneID" id="31676908"/>
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    <dbReference type="Proteomes" id="UP000192050">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="72" mass="8470" checksum="183555A0D9051142" modified="2017-06-07" version="1">MKQEPVKGLDKDTIIDELKWELENNNKIINELQNDTNELKNNNNKLQENVSKLQNNNNGIKNGYKKLKIEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5A0</accession>
    <name>A0A1V0N5A0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2240 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1V0N5A0"/>
    <dbReference type="GeneID" id="16024656"/>
    <dbReference type="GeneID" id="31676915"/>
    <dbReference type="KEGG" id="fai:FAD_1423"/>
    <dbReference type="OrthoDB" id="56136at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018716">
        <property type="entry name" value="DUF2240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09999">
        <property type="entry name" value="DUF2240"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17147" checksum="E32B4152B7581615" modified="2017-06-07" version="1">MNKDMARKLIAIVASKKADGYSKSDFTNILSFKRTLLPPEDVDRFLQVSLESMLLVEKNGKYVPNFSTEGVIVPLDFSIDVDELFSEATEKPLIDRMLEAASASGKMTKKEAIIRAKDLLSGMQFIDFETAIITVLSDSGIDVTPFVQEKENSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5A2</accession>
    <name>A0A1V0N5A2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="16024692"/>
    <dbReference type="KEGG" id="fai:FAD_1462"/>
    <dbReference type="OrthoDB" id="55620at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054581">
        <property type="entry name" value="EncFtn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22277">
        <property type="entry name" value="EncFtn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="11285" checksum="B546A642CCCC00DF" modified="2017-06-07" version="1">MPVYEVGKDLDEKTKDMSRARQSLIEEMQAIMFYDERLDASKDPVLKEVIKHNRDDEKEHFSLLLEYLRRNDPELDRELKEILFSKKELKELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5C3</accession>
    <name>A0A1V0N5C3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5C3"/>
    <dbReference type="STRING" id="74969.FAD_1465"/>
    <dbReference type="KEGG" id="fai:FAD_1465"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008508">
        <property type="entry name" value="Bax1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39640:SF1">
        <property type="entry name" value="DUF790 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39640">
        <property type="entry name" value="VNG6129C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05626">
        <property type="entry name" value="DUF790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019435">
        <property type="entry name" value="UCP019435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="429" mass="49449" checksum="1129CA33583AEAFF" modified="2017-06-07" version="1">MIVRKLKTGLVFPVFLSDENSDYIDSVKTVFNENTGNNRETILKALKELELNSSSTKTIRALSLLFFRNSIFEPPVDVDAPALREDVFKIARIPPVNQDEKRNILKPVEEKYGLSMDEIINGLYADKESELVLHQAYSASNIEIARAYNLEQVETIMMRCSTLYITTSSDWSYTITSIKRLGLLFTAQIDGSKLKSIKITGPLEMFESPERYGSRFAMLIHKISQLENWAIEADIKIKDKFEKTVKVYKLKLSDTVSYYLPESNKTDSINYDFVEKAQPLIVNGTVYFPDYVMKIGDKTVYINITGKTYARQDNEIKENLKGKVNWENIFILRQKDKKMKDEIAFYEDIDFPALKLILSEKYSAKKKLNGELDDNSVDSIKKELEKLYPQTEKMFDYVESQGLIPERVLPALGYKLKWRGLDIIVTKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5D2</accession>
    <name>A0A1V0N5D2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isomerizing glucosamine--fructose-6-phosphate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142919.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5D2"/>
    <dbReference type="STRING" id="74969.FAD_1456"/>
    <dbReference type="GeneID" id="31676949"/>
    <dbReference type="KEGG" id="fai:FAD_1456"/>
    <dbReference type="OrthoDB" id="372195at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="193"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="346" mass="38701" checksum="AEF30E734A251212" modified="2017-06-07" version="1">MTDTIPEKRNGHPYYMYDMIRETPESLEITRKTMENTDYSFLSSKPLLFTGNGTAYHAAQIGAGFLYKTDLKYAFVQSYELLNYYVPVHGTVVGISNSGKTKSTIDSLIYQKKFSYIVGITHYHGTPMELISNKSIVIDADDKSLCNTKSFFDNAIASMYIASRYAGIDMDIDNTIETLKGLVASLDSTVKKIAHNLSYVNRIFVLGAGPEEPVAREAAQKIKEATHIHAEGIELEEFIHGCTSLIDDKSLLIIINSNTVNSRTDDIVRACKVVGTKTVVINGDGDYSIDLPDLGDEYINALLNVLPLYYLAYYMAVEQNVNPDLLRFDEETYRKFDDIVFPPGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5E3</accession>
    <name>A0A1V0N5E3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B12-binding domain-containing radical SAM protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1508</name>
        <name evidence="2" type="ORF">HLB00_07745</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000289">
        <property type="protein sequence ID" value="NOL60721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142938.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5E3"/>
    <dbReference type="STRING" id="74969.FAD_1508"/>
    <dbReference type="GeneID" id="84218101"/>
    <dbReference type="KEGG" id="fai:FAD_1508"/>
    <dbReference type="OrthoDB" id="358785at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42731:SF4">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42731">
        <property type="entry name" value="SLL1084 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="558" mass="62853" checksum="0ED9B28B3351497B" modified="2017-06-07" version="1">MTKYVLISDSTLSYDYRNFPLLDFLPCAPGDKVPGRVYRFLRGPAPEALPNGEAKYAPYAIRKIEAGLLRDNPKKDVAVAHMDYLSNFITDDTEIIGVSTMDPLGIGPTTMSYAALFGGDLDSWVRREWDILIERINQVRKGKKAKLVIGGPGVWEFTVLRDEIDKYHFDYVVSGEMDDIISDLFRGIEHDDIDKNMFTRGYMTYDDHFRRVVKNDELFVGRGTGIRAYPALEDIPEIVNPASKGMVEVMRGCGVGCDFCEVTLRPLRYYSLDRIKKEIEVNVKGGNDHAWLHSDEIFEYKHEKMFTPNQDEMVNLMKTVMSIKGVTGSNPTHGRISIPAAFPELIQKLSTILKAGPDNWIGIQTGVETGSDSLAMKHMPNKTMPLRIGADGSFRDIVWQGVYNETKYYWRSAFTIQVGQQEETDEDNWDSIAMINQLSHSYVDGRPFEFTVTPLVNVPLGRIKSRSLNSMLNPVQMGVYYASYRHLAKMAKRDGFRDANGNIFARAGTGTILSVGGEVMLKVVEKIAKKKGVDIDKVKKWGIESEKEISSLSTLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5E7</accession>
    <name>A0A1V0N5E7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rPA</name>
        <name evidence="4" type="ORF">FAD_1499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142931.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5E7"/>
    <dbReference type="STRING" id="74969.FAD_1499"/>
    <dbReference type="GeneID" id="31676990"/>
    <dbReference type="KEGG" id="fai:FAD_1499"/>
    <dbReference type="OrthoDB" id="6262at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048970">
        <property type="entry name" value="OB_Ssb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005049">
        <property type="entry name" value="PRK06461.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21473">
        <property type="entry name" value="OB_Ssb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="3">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="158" mass="18114" checksum="2629287BE6237B0D" modified="2017-06-07" version="1">MDEITKIKDLTPSSRRVNVVGKVVVLGEPKEIKTRFGEDKSVSEVIVADDTGKITLTLWDDQTKDIRDGEVLKIDNGYISLLRGHMRLNVGKYRAMAESEEEIEPNEELDMSEKEYEYQYNNYNNRYGNQGNRGNGGRGGFGNNNRRSNYNRNDDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5I8</accession>
    <name>A0A1V0N5I8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886704.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5I8"/>
    <dbReference type="STRING" id="74969.FAD_1562"/>
    <dbReference type="GeneID" id="16024833"/>
    <dbReference type="GeneID" id="31677053"/>
    <dbReference type="KEGG" id="fai:FAD_1562"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011529">
        <property type="entry name" value="PRK14968.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="5">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="180" mass="20103" checksum="C10F080203F29973" modified="2017-06-07" version="1">MINIDYSDDVYKPSDDTYLILDNAECGKSVLEMGSGSGLIAITLARQGHSVTAADISPEAINLIKHNAFINNVDMEIVRSDLFENIHGKYDTIIFNPPYLPVEGESPQWAGGKDGFAVTGKFLATAHEYLNPGGNIFLILSDLTDIESFIEKNRKYEFIKLKSMSFDFEAILLYELKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5K1</accession>
    <name>A0A1V0N5K1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5K1"/>
    <dbReference type="STRING" id="74969.FAD_1525"/>
    <dbReference type="KEGG" id="fai:FAD_1525"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="544" mass="58142" checksum="0E8CBD0C51B2906D" modified="2017-06-07" version="1">MSGQTPILILKEGTERQQGKNAQKNNIEAAKAIADAVRTTLGPKGMDKMMVDSIGDIIISNDGATILKEMDVDHPTAKMIVEASKSQDTAVGDGTTTVVVFAGELLKQAEALLDQGVHSTIIADGYHLAAEEARKQLLAMSVSAKDDAMLRKIAITALSGKNTGVAPEFLADLVVNAINSVTETDGDKIIVDTANIKVDKKSGGSAADTKFINGLIIDKEKVHSKMPSVVKNAKIALINSALEIKKTEIDAKVQITDPSKIQEFLDQESDTLKEMAEKIKKSGANVVLCQKGIDDTVQYYLAKYGIYGVRRVKQSDMEKLAKATGAKMITDLDDITEETMGKAETVEERKIGDDRMTFVTGCKNPKAVNILIRGGTEHVVDEIDRSLNDAIRVVAITKEDGRYLPGGGATEAELAMKLRSYSNSVGGREQLSIEAFAKALEIIPRTLAENAGMDPINTLISLKSEHEKGNKNFGVDMEANKITDMIKAGVFDTFRVKTHAISSAVEVATMILRIDDVIASKKSSAPQGGAGGMGGGMPPGMGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5L0</accession>
    <name>A0A1V0N5L0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclodeaminase/cyclohydrolase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Formiminotransferase cyclodeaminase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1542</name>
        <name evidence="4" type="ORF">HLB00_03565</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000114">
        <property type="protein sequence ID" value="NOL59911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886682.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5L0"/>
    <dbReference type="STRING" id="74969.FAD_1542"/>
    <dbReference type="GeneID" id="16024811"/>
    <dbReference type="KEGG" id="fai:FAD_1542"/>
    <dbReference type="OrthoDB" id="56828at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="entry name" value="Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="Methenyltetrahydrofolate cyclohydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclodeaminase/cyclohydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="200" mass="22222" checksum="407F6B04246AE702" modified="2017-06-07" version="1">MDLDEYISRLKSSSATPGGGSASAISSIFAASLNSMAALLSTGKPKLSAYENDFKQISEESDNIIEKLKILSNEDEKSFQGIMDALHMDKADKNRRTAIDMAIQNSIGVSWDIARISIHNMENALYLCEHGNRNLITDSITAAYMAYATVHTSLNNIKINLKFQKSVDFKAEELLKLKFFMEAVEFVMEKVKKIESSVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Q0</accession>
    <name>A0A1V0N5Q0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acidic ribosomal protein P0 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl10</name>
        <name evidence="6" type="synonym">rplP0</name>
        <name evidence="9" type="ORF">FAD_1618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886749.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Q0"/>
    <dbReference type="STRING" id="74969.FAD_1618"/>
    <dbReference type="GeneID" id="16024883"/>
    <dbReference type="GeneID" id="31677107"/>
    <dbReference type="KEGG" id="fai:FAD_1618"/>
    <dbReference type="OrthoDB" id="30930at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00280">
        <property type="entry name" value="Ribosomal_uL10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022909">
        <property type="entry name" value="Ribosomal_uL10_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="8">
        <location>
            <begin position="107"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="318" mass="34653" checksum="83266CA68BD520A5" modified="2017-06-07" version="1">MIEPAQWKVDKVNALTEELNESPVSAVISIKGLRNKEFQKIRSDIRGKVKIEVLRARLLRLALQKSNKKNIAGMTEHATGQIALITTSETPKTVYDMLVSKRTKAAARGGEIAEEDIIIEPKETSFPPGPMISVFQKAGIPAGIEKGKIVIKSEVTLVKKGEVISKEKAQVLEKLEILPVTVGLEMIAAYSDRLVYSRDALSITIEQIVSDMAGAFLKAKALALKADFLVPEIMPELLSKAYLQAQGLALAANFVDEKNIDIFIRKAVINATTLNSLINKDLNNENIENENPEESQTEDKKDEGSGDDAAAGLGSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Q3</accession>
    <name>A0A1V0N5Q3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps9</name>
        <name evidence="7" type="ORF">FAD_1596</name>
        <name evidence="8" type="ORF">HLB00_01555</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000041">
        <property type="protein sequence ID" value="NOL59522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886729.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Q3"/>
    <dbReference type="STRING" id="74969.FAD_1596"/>
    <dbReference type="GeneID" id="16024862"/>
    <dbReference type="KEGG" id="fai:FAD_1596"/>
    <dbReference type="OrthoDB" id="52677at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_A">
        <property type="entry name" value="Ribosomal_uS9_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019958">
        <property type="entry name" value="Ribosomal_uS9_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03627">
        <property type="entry name" value="uS9_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="134" mass="15048" checksum="92E27C7A21631C19" modified="2017-06-07" version="1">MSNEILTIGKRKTAVARAITRKGNGKVFINGKPVELYPIELLRNKVMEPLKILGDRANEIDIEIKVTGGGNTGQTDAARTAMAKGIVKYFSDDHELENTIRTYDRTMLVNDIRRKMPKKPMGSGARAKRQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5T2</accession>
    <name>A0A1V0N5T2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
            <ecNumber evidence="3 10">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dph2</name>
        <name evidence="11" type="ORF">FAD_1627</name>
        <name evidence="12" type="ORF">HLB00_02455</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000075">
        <property type="protein sequence ID" value="NOL59695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886759.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5T2"/>
    <dbReference type="STRING" id="74969.FAD_1627"/>
    <dbReference type="GeneID" id="16024894"/>
    <dbReference type="GeneID" id="84218221"/>
    <dbReference type="KEGG" id="fai:FAD_1627"/>
    <dbReference type="OrthoDB" id="314at2157"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL59695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="334" mass="37957" checksum="182C2282286CC27E" modified="2017-06-07" version="1">MEVDDAIIRLREMKASKILLQIPDGLKPESFNLFNKFSKEFNVIISSQSFYGACDIGNMEVYRDVDCIVQFGHSEIPNIKYTKPILFIEYFYKQIELDDDIFSILAENLVKNVGLLSSVQYYKEMEYVNGKLKELGYNVIVGNVDGRMKYPGQVLGCNFSAAHSIAAKVDAYLLVSTGLFHGIGAQLSTDKPVYILDLNNRSIRNIQPDIDKFLRKRYARIEPAIDAKKFAIVIDTKIGQYRKKLAYSIYNRVKGMGRDAIIVTADNINPVDFQNLMCDAVVFTGCPRVSIDDEDKFSMPVLTPIEFEQLFGFKSNNKYIMDEIVGVDSYSPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Y1</accession>
    <name>A0A1V0N5Y1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-acyl-L-amino acid amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Can release basic, acidic, aromatic, and, to a lesser extent, aliphatic amino acids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143020.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Y1"/>
    <dbReference type="STRING" id="74969.FAD_1678"/>
    <dbReference type="GeneID" id="31677170"/>
    <dbReference type="KEGG" id="fai:FAD_1678"/>
    <dbReference type="OrthoDB" id="247417at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000014">
        <property type="entry name" value="N-acyl-L-amino acid amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="174"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="381" mass="42453" checksum="5C0482309976B2F1" modified="2017-06-07" version="1">METEEYIIAMREYFHENPELSFKEFKTADRLEKELRDMGLNPKRITETGIIADIKGKGKKTVAIRADIDALPVTEENKVDYVSKNKGVMHACGHDTHMAMLLGAAKMLIAEKEKLNGNIRLIFQPAEELPPGGAVGMIKNGALDGVDYIIGQHIMGFIPAGKIAIYYKEMMANADEFDIKIHGKGGHGSAPQDSIDAVYITAHLIEMLNTIVSREIDPQEPAVITTGTVNSGYRYNIIAAHAELTGTVRTFNTEIQEKIIKRIKDILEGLKSIYGIEYEYEYKKGYPVLVNNEKIAKYIEEAAKRVVGKDNIIYPKPNMGGEDFAYFLQKVPGSYYFIGGSNPERGIDSMNHSPTFDMDESALYTGAKVLKEAAMEILNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Y6</accession>
    <name>A0A1V0N5Y6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143013.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Y6"/>
    <dbReference type="STRING" id="74969.FAD_1670"/>
    <dbReference type="GeneID" id="31677161"/>
    <dbReference type="KEGG" id="fai:FAD_1670"/>
    <dbReference type="OrthoDB" id="194879at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="277" mass="30196" checksum="EF8C429959266E21" modified="2017-06-07" version="1">MFKENLLKDKNILITGGGTGLGKQMTETFLKLGATVSIISRKEEHLTAAKEYFNNMGYKIEAVKCDIRNPDEIKNAVDLIESKTGKINVLINNAAGNFISRTEDLTPKAFDTVMGIVLHGTAYASLEMGKRWISNSMKGTILSIVATYAWTGSGYVVPSAISKAGVLALTRSLAAEWGHKGIRTVAIAPGAFKTEGAWSRLLPGDDYEKQLISGNPERRLATKEEIANIAAFLISDMASYINGEVVTADGGQALYGSSMFNMMESLPDDIWKMMRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Y7</accession>
    <name>A0A1V0N5Y7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="14">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="14">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 18" type="primary">ileS</name>
        <name evidence="18" type="ORF">FAD_1652</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="14"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142997.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Y7"/>
    <dbReference type="STRING" id="74969.FAD_1652"/>
    <dbReference type="GeneID" id="84218245"/>
    <dbReference type="KEGG" id="fai:FAD_1652"/>
    <dbReference type="OrthoDB" id="30823at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000063">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000075">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="16">
        <location>
            <begin position="23"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="673"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="14">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="14">
        <location>
            <begin position="590"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ARD85496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1024" mass="118616" checksum="083F81F528413E35" modified="2017-06-07" version="1">MSSNFYQTIDVNKSSMDIEKEIRKYWKENKIIEDILNKDRNLKRYTFLEGPPTANGRPHVGHLMTRTVKDTVMRYKYMSGYDIGRRTGGWDCHGLPVELEAEKHFGFNTKKEIEDFGIEKFNEYCRNSVFTYIDEWNEVDSEIGYWIDENKSYVTLRNDYMESEWYALKKLFDENMLVKDYKIVPYCPRCGTSLSSHEVAQGYKNTDDISVYVKFRVKGSMNRYLIAWTTTPWTLPSNELLVVNKDFDYSLVSDGNNEYYVLSSTVQSLFKDAKVLKTMKGKDLVGTRYEQLMPFLHVGSNALQVVPGDFVTAEDGTGIVHAAPAFGADDFDIAKEYNVSLINPVDSEGKFDNSVPWKDKFVMDVNPDIIGYLKENNLLFKSQKIKHTYPFCYRCGTKLLYYPLDAWFIKVSTIRELLKKNNDKVNWYPEYLKDGRFGNFLNDAKDWALSRNRYWGTPLPIWKCSNGHYLAVGSREDIEKHGGNIPDDLHRPFIDAVKLKCPECSETMEREPYVIDTWFDSGSASYAAMHYPFNKNFDTEGIPVDFITEAIDQTRGWFYTLHVISSLLFGRNAYKNVMSMSFILDENGQKMSKSKGNFVTARDFISMYGADPARLFFYTGAPWNSKSIDKKLIGDTARKVFGTLSNVYSFFASNANLDGFVFQDLEPSSNLLDRWLLSRLNSTIENTRKNMDEFDMHIALRNIMDLINDFSNYYLRLSRKRFWEGKLDDEKKRAYETLYYTLINILKLLAPLAPFYTDYMYQKLSGPEKTIHSEKYPEPDNNYIDSDLEKEFKYAISIMELSRRARQESNIKGRQVVGNIMLYSDMELNPAILDIISPELNSMDIKFIPFGERPVKTTVKPVFSKVAPVLRGDTNKFAEYLNSENIYSELKKTGKITYKGNEFTPDFFEIHEDPSPEYAFASDEKTGISVFINKNIDNNLLLAGYAREIIRRIQIMRKDLNLEYSRNIKTEINVSGDIRKSIEKFMDLIKNETLSKSIEFSSSTDGKTWDIDGENVQISITPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N611</accession>
    <name>A0A1V0N611_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1611 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143050.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N611"/>
    <dbReference type="STRING" id="74969.FAD_1717"/>
    <dbReference type="GeneID" id="31677208"/>
    <dbReference type="KEGG" id="fai:FAD_1717"/>
    <dbReference type="OrthoDB" id="30617at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011669">
        <property type="entry name" value="DgcN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035086">
        <property type="entry name" value="DgcN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035402">
        <property type="entry name" value="DgcN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40690:SF1">
        <property type="entry name" value="DUF1611 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40690">
        <property type="entry name" value="GLL3100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07755">
        <property type="entry name" value="DUF1611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17396">
        <property type="entry name" value="DUF1611_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026760">
        <property type="entry name" value="UCP026760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-glutamate N-acetyltransferase-like N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="D-glutamate N-acetyltransferase-like C-terminal" evidence="1">
        <location>
            <begin position="141"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38519" checksum="8E588734CADDE97D" modified="2017-06-07" version="1">MEKAVVLSEGCFATTYGKTANGLVRYSKRYDIVAVIDSRYYGMDAGYVLMGRQNGIRIVSTIQEAKALGATTLIIGVATDGGYLPVEYRQYVSTAIEEGMNIVNGLHQYISNDNEFSKLAKIYDVEITDVRKIFNNYEYSFTGKIQEVKSKKIAVLGTDSAIGKRTTAVYLNDAMNRKKKQSELIGTGQTSWMQGFPYTVVMDSIINDFVAGSLEYITYKAWQEKHPEYMFLEGQGSILHPAYPGGFEIIGAMRPDAIILQHAPKRKFYDGFPEYPIEPLEKYIKVLELVSNKKVIAISLNTENMEKSEIEVEKTKLEKIYNIPVFDPLEEFENITGVISDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N633</accession>
    <name>A0A1V0N633_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143057.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N633"/>
    <dbReference type="STRING" id="74969.FAD_1724"/>
    <dbReference type="GeneID" id="31677215"/>
    <dbReference type="KEGG" id="fai:FAD_1724"/>
    <dbReference type="OrthoDB" id="31092at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010341">
        <property type="entry name" value="PRK13768.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="259" mass="28944" checksum="85C54EF1EDA0A630" modified="2017-06-07" version="1">MIGSLFVTGPAGTGKSTFCGAYKDWLVQNDYDAIIVNLDPGAEYLPYEPDIDIREFISLSEVMSAYSLGPNGAQVVAADLLLDNVDKIKSKLELYDDYYVIFDTPGQIELFTFRPGSPLLVKSLAGEKAMIAFIADSMVSQTPSGFISEKMLFGSVYSRFFVPMMFVLNKIDLIGEDRVKEITAWEENPDLLYDSFRDENTDSVKDYFLNVITALKDSDIINKIVPVSSKDSFGFEDIYTGMSDFFQGGEDTDTMYKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N634</accession>
    <name>A0A1V0N634_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kef-type potassium transporter NAD-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N634"/>
    <dbReference type="STRING" id="74969.FAD_1771"/>
    <dbReference type="KEGG" id="fai:FAD_1771"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050721">
        <property type="entry name" value="Trk_Ktr_HKT_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43833">
        <property type="entry name" value="POTASSIUM CHANNEL PROTEIN 2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43833:SF9">
        <property type="entry name" value="POTASSIUM CHANNEL PROTEIN YUGO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="237" mass="26355" checksum="827020654861A514" modified="2017-06-07" version="1">MLAGIGTVTTLTASTAAYMTNVKLKHKIKSIRMKNHTIICNYNDYSKNIILNYLNRKLKIDSLVLIANLQENPVKSDYVFFTPGDPTDEKTLAEANASEAKRFIVTGDFSSNVPLNLIDAKTILNIFQIRKLNKSAEIIAQVASSDNVTNAKSAGADEVITLNELSALVISKSIMNPKLPDFVLRLLSSGDGPKIYSVKIPDKYIVYNLLDFKKIFKKIVVLSVFSENDYIFPVEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N636</accession>
    <name>A0A1V0N636_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic phosphate:H+ symporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143070.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N636"/>
    <dbReference type="STRING" id="74969.FAD_1753"/>
    <dbReference type="GeneID" id="31677244"/>
    <dbReference type="KEGG" id="fai:FAD_1753"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="21"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="467" mass="51161" checksum="E7E23CC40733DC14" modified="2017-06-07" version="1">MSSAIDRSMDEAKTSKFHYKVLFISGLGFFTDAYDLFIIGVVILLLPYAGWHNISIFYKGLVTSTALLAAVIGSVVFGRLLDYSGRKAIYGFELVALIAGSLGSAFLTPVNNIFMLLFWRFLLGVGIGGDYATSSTIMTEYSSTMNRGKFVGMIFSMQSFGLIAGPLISIAFLSNYVSPYITWRLLLAIGAIPAIIVIYFRRTMPEPPRYTADVRGDYKLAAKNLKTFAGLDSTGSKGKTINAPWYVLFRDRKFLLTLIGTAGAWFLMDWAFYGNSIMSNSILSFLVPSTVSGIHSIIMTNEYSAIIFGVAAFPGYWIAAFTIDRIGRKPVQITGFAMMAISFGIISAFSFLTTYRFLDYLLLLYGISYFFIMFGPNVTTFVYPPEVFPISTRGLGTGISAAGGKTGAFIGTLADTIILSITGLHFLMGMLAIIAAIGLILTIVLLPETKRRDLGETSGEARYAEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N655</accession>
    <name>A0A1V0N655_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium-dependent phosphatase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1745</name>
        <name evidence="3" type="ORF">HLB00_03915</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000127">
        <property type="protein sequence ID" value="NOL59979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143068.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N655"/>
    <dbReference type="STRING" id="74969.FAD_1745"/>
    <dbReference type="GeneID" id="31677236"/>
    <dbReference type="KEGG" id="fai:FAD_1745"/>
    <dbReference type="OrthoDB" id="27736at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="168" mass="19470" checksum="A59B56E7555123E1" modified="2017-06-07" version="1">MIRPWILAMDLDGTVWDHLNISGVNPPYTRLDSNSIGNQDNVTVTLFPEALDFIRWARENGAITTTLSWNRKDYAQEALETFGICNLFDYNSTDQTPDKDQRLLKLISLLKKEGVEIPVQRVVYVDDRDLHMEAIRKNIGDIVFINIWKTTKTYHDAMEIVKMKILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N673</accession>
    <name>A0A1V0N673_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N673"/>
    <dbReference type="STRING" id="74969.FAD_1772"/>
    <dbReference type="KEGG" id="fai:FAD_1772"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="37" mass="4277" checksum="E2116C000C6CA071" modified="2017-06-07" version="1">MNILKRILIKIERYTGSNVFKTVLILILIVLVGSYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N676</accession>
    <name>A0A1V0N676_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">A-type ATP synthase subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ntpD</name>
        <name evidence="4" type="synonym">atpD</name>
        <name evidence="6" type="ORF">FAD_1819</name>
        <name evidence="7" type="ORF">HLB00_01785</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Has multiple subunits with at least A(3), B(3), C, D, E, F, H, I and proteolipid K(x).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000045">
        <property type="protein sequence ID" value="NOL59566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N676"/>
    <dbReference type="STRING" id="74969.FAD_1819"/>
    <dbReference type="KEGG" id="fai:FAD_1819"/>
    <dbReference type="OrthoDB" id="117390at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001545">
        <property type="entry name" value="PRK00373.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="147"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="216" mass="24650" checksum="E8F6AFAF7D45545A" modified="2017-06-07" version="1">MGGIMANTVRLTRIELINTKKRIKVASRGLELLKMKRQSLVMEFFKISNEVRGLRENIKNDIEKGLNAIKVAEIIDGTLEIERISYMFSSPEIKIGGKNIMGVTIPEMSAQAGKKIIDDSYLANSVPVSIYDAITLFNKIFKELLEVSQKESSMRKLLNEIDKTNRRSNAIENIMIPRFNNNYKIIREHLDELERDSFATLKFVKSHVVSTGENNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6D4</accession>
    <name>A0A1V0N6D4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Homocitrate synthase</fullName>
            <ecNumber evidence="5 13">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_1797</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5 13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143098.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6D4"/>
    <dbReference type="STRING" id="74969.FAD_1797"/>
    <dbReference type="GeneID" id="31677287"/>
    <dbReference type="KEGG" id="fai:FAD_1797"/>
    <dbReference type="OrthoDB" id="57343at2157"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42880">
        <property type="entry name" value="HOMOCITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42880:SF1">
        <property type="entry name" value="ISOPROPYLMALATE_HOMOCITRATE_CITRAMALATE SYNTHASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="14">
        <location>
            <begin position="5"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="NCBIfam" id="TIGR02146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="377" mass="41140" checksum="18E716942CE4538B" modified="2017-06-07" version="1">MPLKVGILDSTLREGEQTPGVLFNKNQRIEIAQLLSDAHVAMIEAGHPLVSPDIYSAIKEIMDMKASGMINSEIIAHSRAVNSDIDSAASLGVDRIAIFYGVSDIHLDNKTHRSRTEALDIIYDSISYASLTGIPVRFTAEDASRTDINFLRNVVRTAVDAGADRVSIADTLGILTPEKTAYIFNNLSDIKGVEYDFHGHNDMGMALANGLAAAESGATIIHSTVNGLGERVGIIPTQALGVLLNYHLGVDAINLLSLKPLSELIEKYSGITMPPNYPVTGSTAFTHKSGVHVDGIIRNPGTYEFMDPSRLGLQHSFTIDKYSGKHALREKLANMGINADDNKISYMLEKIKNNNMVYSEDDLKEIANSDNQRHYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6D5</accession>
    <name>A0A1V0N6D5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxiredoxin</fullName>
            <ecNumber evidence="9">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_1856</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homodecamer. Pentamer of dimers that assemble into a ring structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887005.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6D5"/>
    <dbReference type="STRING" id="74969.FAD_1856"/>
    <dbReference type="GeneID" id="16025139"/>
    <dbReference type="GeneID" id="31677346"/>
    <dbReference type="KEGG" id="fai:FAD_1856"/>
    <dbReference type="OrthoDB" id="6924at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00401">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022915">
        <property type="entry name" value="Peroxiredoxin_TDXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009669">
        <property type="entry name" value="PRK13190.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="9">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="204" mass="23326" checksum="59DCF9CC810B5BB4" modified="2017-06-07" version="1">MAVYLGQKAPGFLVNTTKGPLSLEDYKGNWVILFSHPADFTPVCTTEFMAFARRYDEFKKINTELIGLSVDSIYSHIEWMKNIKEKFGIEIPFPVIADINKDVAREYNMMDEKTGSTVRGVFIIDPNMIVRLMIYYPAETGRNIDEIMRTLKALQMNWDRKLAAPVNWQPGNDGIVSAPGTLDEAINREKNGSKTWYLTYEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6D8</accession>
    <name>A0A1V0N6D8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Nascent polypeptide-associated complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nac</name>
        <name evidence="7" type="ORF">FAD_1845</name>
        <name evidence="8" type="ORF">HLB00_08325</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Contacts the emerging nascent chain on the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with the ribosome. Binds ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000311">
        <property type="protein sequence ID" value="NOL60830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886992.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6D8"/>
    <dbReference type="STRING" id="74969.FAD_1845"/>
    <dbReference type="GeneID" id="16025126"/>
    <dbReference type="KEGG" id="fai:FAD_1845"/>
    <dbReference type="OrthoDB" id="53273at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14359">
        <property type="entry name" value="UBA_AeNAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00814">
        <property type="entry name" value="NAC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005231">
        <property type="entry name" value="NAC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00264">
        <property type="entry name" value="archaeal-type nascent polypeptide-associated complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="110" mass="12346" checksum="528A5A2BAAEC7B61" modified="2017-06-07" version="1">MNPRDVRRMMNQMGIKSTEMPDVKEVILKGKDKDYIIENASVTMIEAQGQKTFQVLGTMKEKPKSASVEEFDDEDIKLVMSQCNVSREKAIEALRKADGEPAQAIIDLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6E3</accession>
    <name>A0A1V0N6E3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">A-type ATP synthase subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ntpB</name>
        <name evidence="8" type="synonym">atpB</name>
        <name evidence="12" type="ORF">FAD_1820</name>
        <name evidence="13" type="ORF">HLB00_01780</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane. The B chain is a regulatory subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Has multiple subunits with at least A(3), B(3), C, D, E, F, H, I and proteolipid K(x).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000045">
        <property type="protein sequence ID" value="NOL59565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886970.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6E3"/>
    <dbReference type="STRING" id="74969.FAD_1820"/>
    <dbReference type="GeneID" id="16025100"/>
    <dbReference type="KEGG" id="fai:FAD_1820"/>
    <dbReference type="OrthoDB" id="32941at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="9">
        <location>
            <begin position="132"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="11">
        <location>
            <begin position="356"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL59565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="458" mass="50544" checksum="6CCC6725A2EF49FD" modified="2017-06-07" version="1">MSDIIYRSISQINGPLLFVDDVKNASYNEIVSIILDNGERVKGQVLETRNGVAVVQVFGSTTSMSPKSTGVSFTGSTFKLPVSDDMLGRIFNGFGEPVDNGPKIYSKDKVDITGAAINPYSREEPSEFIETGISTIDGMNTLVMGQKLPIFSGAGLSHNRLATQIAKQAKTLKGGEKFGVVFGAIGITSEEANYFMKQFESSGALSESVIFLNLASDPSMDRIILPRVALTTAEYLAYEKDMNMLVILTDMTNYCEALREISSSREEIPGRRGYPGYMYTDLSTIYERAGKIKGRNGSITQIPILTMPGDDITNPVPDLTGYITEGQITLSRDLSRKDIYPEVDVLLSLSRLMNQGIGSDHTREDHRGLADQLYSSYAKGKDARALSEIVGEEALSVSDKKYLQFAEDFESKYVNQGDTDRSIEETLNLGWDLLSILPKEEMKKVKSAYIPKYGKWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6E8</accession>
    <name>A0A1V0N6E8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">A-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ntpI</name>
        <name evidence="11" type="ORF">FAD_1817</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143107.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6E8"/>
    <dbReference type="STRING" id="74969.FAD_1817"/>
    <dbReference type="GeneID" id="31677307"/>
    <dbReference type="KEGG" id="fai:FAD_1817"/>
    <dbReference type="OrthoDB" id="85892at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="642" mass="72372" checksum="94C37C3FFF774088" modified="2017-06-07" version="1">MLKPVKMTKIRIIGLNTYKNKIVDDMHDLNVIQIENAEPEVAKVFNTQGSNANYKVLSENLSRFKGFLSILPQREVKHKKYYSSPEEVLEDISKIYIAGELNKLKDDEEKLTAKIQENKITLKPLELLSGFGEDLSILNNDYVESFIIKSSDETESLKTDYATFINLNNGYSTVTINRKNEPEFLSILSSKTYDMMKIPELNGTVKENIELIHNTINEASNAIEGIKSSLNALSDKYYEPVAQITEQLEIYVKEEEILSNIAFSENAFALEGWIPESEYEKVSSVLNEDSNNTMFIQKIETKEDPPTKLSNPKHFKIFEFFIRFYSLPEEYEFDPTMIFALVFPVFFGLMVGDAGYGLVILLISLFIIHRVDHPPAKSHIPKKLSGFILMIMGKNSLKTLAKALIPSSIIAIIFGIVFNEFFGFTIYPVPFRLSSTPVPVIHIGELLMISGYIGLAFVTFGFVLGIINNAYINHRKAAVAKVGWILMAWAFAILGLNLIHRVSLSPLETSSLIGYVMLIVGFITVVVFEGTLSLMEIPSIISHILSYTRIVGILLASVVLVLVIDTVFRATLSDPFYFIIIGVVVLVVGQLFNLIIAVFEPGIQGARLLYVEFFSKFYFGNGKPFSPFGSNRRFTLKKFDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6G2</accession>
    <name>A0A1V0N6G2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="3">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM isomerase</fullName>
            <shortName evidence="3">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lysU</name>
        <name evidence="3" type="synonym">leuD</name>
        <name evidence="5" type="ORF">FAD_1838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143116.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6G2"/>
    <dbReference type="STRING" id="74969.FAD_1838"/>
    <dbReference type="GeneID" id="31677328"/>
    <dbReference type="KEGG" id="fai:FAD_1838"/>
    <dbReference type="OrthoDB" id="6505at2157"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01032">
        <property type="entry name" value="LeuD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050075">
        <property type="entry name" value="LeuD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345:SF2">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="4">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="160" mass="17752" checksum="68DF61F3174EE740" modified="2017-06-07" version="1">MVNNIKGRAIVLGDNVDTDQIIPAKYLNTSEPDKLAPHFMENEYPDLAANIMKGDIIVAGKNFGSGSSREHAVITIKGLGISCIIAESFARIFFRNAINTGIPVIEAKIEATEYGEISIDFDKSIIMHNGITTQFKEYPEFLRNIIDSKGLVNYVWSGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1D3</accession>
    <name>A0A1V0N1D3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0025</name>
        <name evidence="3" type="ORF">HLB00_09080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000370">
        <property type="protein sequence ID" value="NOL60972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141244.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1D3"/>
    <dbReference type="STRING" id="74969.FAD_0025"/>
    <dbReference type="GeneID" id="84218515"/>
    <dbReference type="KEGG" id="fai:FAD_0025"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="157" mass="16711" checksum="EB75F237E565E1B9" modified="2017-06-07" version="1">MFEINIVESSVLYRKRKGLSSNMAIGSMQKDNREHYKRVAKAIVMVSLFCMISGAGYLSIAGVPIIEDASHMLPGALINTGTSHGNFLYYYFTHGHFPTASTWFNWLTVTMGLEPSVAILVADALGAAGWITEATADAILAASGYVGAAIGAAIAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1F3</accession>
    <name>A0A1V0N1F3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF655 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887058.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1F3"/>
    <dbReference type="STRING" id="74969.FAD_0047"/>
    <dbReference type="GeneID" id="16025193"/>
    <dbReference type="KEGG" id="fai:FAD_0047"/>
    <dbReference type="OrthoDB" id="7902at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160975">
        <property type="entry name" value="AF1531-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD83982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="21143" checksum="1B7233C95418880D" modified="2017-06-07" version="1">MEEYAYIIDFLPQGRADDKNFRKSPLILAIGESEFKLLEIIPKVDAVVTVGDKIYIGKSPEKRDKIISIKRRITYKDLTSAAISELPYTIENIIDDNPQRFVDFFNNAEAINTRMHTLELLPGLGNKSMWSVLDERKKGPFKSFEDISERVKSVHNPKKMVVNRIMDELQNRYEKYKLFVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1G2</accession>
    <name>A0A1V0N1G2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0055</name>
        <name evidence="3" type="ORF">HLB00_04625</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000159">
        <property type="protein sequence ID" value="NOL60119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141271.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1G2"/>
    <dbReference type="STRING" id="74969.FAD_0055"/>
    <dbReference type="GeneID" id="31675568"/>
    <dbReference type="KEGG" id="fai:FAD_0055"/>
    <dbReference type="OrthoDB" id="56361at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39909" checksum="A53BE370B0C785C0" modified="2017-06-07" version="1">MANLIYGINFDVLFLIVVIASMVTMFATELMAVVPIATRFKDNKTRVNVLSYIVPVWEVVGTFFVLWLVDMENVIPVLMPSIAYALFPLFAVFIFFLVVRNSFIIYAEFVWHENKYFDERKLYAVYSIATFIMGIMALSVLAAITSGYGVHIYGFVKGSSTSYASSYTNFGVFYSHLGVIGFIIGALILANGIGMVFYRLTDIKTAMGKYLPLILVIIGLAIFMPSYYSISAKDYSVNNAFIVIPIVLALVIPILYAFKGTTHLASYKPFIVILTIISITFLELKAYPYVFGNANMVANIPAVTTDSAMEYLAFIISVVGGIWLVLMMIYYAYVSNHRIARLIPEHKPTAKAPEPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1G9</accession>
    <name>A0A1V0N1G9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein FAD_0009</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141236.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1G9"/>
    <dbReference type="STRING" id="74969.FAD_0009"/>
    <dbReference type="GeneID" id="84218500"/>
    <dbReference type="KEGG" id="fai:FAD_0009"/>
    <dbReference type="OrthoDB" id="15207at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="Endo_dU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="UPF0215 PROTEIN MJ1150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518:SF2">
        <property type="entry name" value="UPF0215 PROTEIN MJ1150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="Endo_dU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006380">
        <property type="entry name" value="UCP006380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="190" mass="21012" checksum="652614B143E0C736" modified="2017-06-07" version="1">MKSGLRVLGLDDGPFNRNSDTKTVMVGVLMRLNSYVEGISTGTIKVDGMDSTETIMSMLNGRFSKDIDFIMSNGITFGGFNIMDIRMINRLTGIPIISITRKKPDMDSMFSALKLHFSDYMQRIELLKNSSINKIEYSGKALYVNCCGISVNDALYLIKKTTIMGNIPEPVRMAHLIATAIVSGESYGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1J0</accession>
    <name>A0A1V0N1J0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1J0"/>
    <dbReference type="KEGG" id="fai:FAD_0030"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="174" mass="20743" checksum="306FA29501A77C03" modified="2017-06-07" version="1">MYIKHLLNAMDNRIKNVENILDMEFIKSFIVFIYNDKLLNNMDLIIENLNDGKLDSVDSLFENIIPDAENAITSIYKFLGKKDDLTKKFVAVIENFQWVKYFFVWYGIVIISLYQIYYFYRFSRYMEIHGQFIFGMLYSFLAVFILSVIVFTTISSIRVHNINTIIKNINMNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1K7</accession>
    <name>A0A1V0N1K7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component Rrp42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rrp42</name>
        <name evidence="7" type="ORF">FAD_0041</name>
        <name evidence="8" type="ORF">HLB00_02700</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family. Rrp42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000086">
        <property type="protein sequence ID" value="NOL59743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887052.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1K7"/>
    <dbReference type="STRING" id="74969.FAD_0041"/>
    <dbReference type="GeneID" id="16025187"/>
    <dbReference type="GeneID" id="84218532"/>
    <dbReference type="KEGG" id="fai:FAD_0041"/>
    <dbReference type="OrthoDB" id="30932at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000017">
        <property type="entry name" value="Exosome complex component Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00622">
        <property type="entry name" value="Exosome_Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020869">
        <property type="entry name" value="Rrp42_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003282">
        <property type="entry name" value="PRK04282.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="5">
        <location>
            <begin position="35"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD83976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="260" mass="28475" checksum="7778D58764FA6123" modified="2017-06-07" version="1">MPMDSSAVLSEIRKGFILESIKTGKRLDGRGLQDYREIKITENFVPKAAGSAMVEIGKTKVVAGIKVEEGDPFEDSPDSGVMALNIELLPMAFPTFESGPPSEQAIEYSRVVDRGIRESKMVDTSKLVIESGKRVWMIFVDIDVLNYDGNIIDAATLAAVTALKNTVVPASKIGQKDYSLPINATPVSITMVKIGDEIVCDPDLEEEQVSNGRITVTIAEDHNIHAMQKGDIGEFSLDEIRKAIKTSSDIGNRLRESYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1M4</accession>
    <name>A0A1V0N1M4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps19e</name>
        <name evidence="5" type="ORF">FAD_0074</name>
        <name evidence="6" type="ORF">HLB00_07335</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887083.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1M4"/>
    <dbReference type="STRING" id="74969.FAD_0074"/>
    <dbReference type="GeneID" id="16025219"/>
    <dbReference type="KEGG" id="fai:FAD_0074"/>
    <dbReference type="OrthoDB" id="371836at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_eS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_eS19_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006811">
        <property type="entry name" value="PRK09333.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="150" mass="17376" checksum="0481C3EB5D7C850A" modified="2017-06-07" version="1">MVDVKEVPADLLLNKLASEFKEKNVEIPDWVNYLKDGIGKERAWVQDDWYYTRLASIMRKVYLNTNIGISRLSQEYGSRQDRGTKRYHPVQGSRFIIRNILQSLEALGYLKKDTRTGRSLTPAGQSMLDKAAKEVMKSLAEKDKVFEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1N2</accession>
    <name>A0A1V0N1N2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0096</name>
        <name evidence="2" type="ORF">HLB00_01735</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000044">
        <property type="protein sequence ID" value="NOL59556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141327.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1N2"/>
    <dbReference type="STRING" id="74969.FAD_0096"/>
    <dbReference type="GeneID" id="84218586"/>
    <dbReference type="KEGG" id="fai:FAD_0096"/>
    <dbReference type="OrthoDB" id="229881at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="107" mass="12444" checksum="43A0BD22BCB097CE" modified="2017-06-07" version="1">MNDYSIFKEIRENIETLERHMTIIKTLLMEQPLGIIKMSQQTGIPEHKIRYSLRILEHEGIIEASREGAILTSDFLGNKDQILKAARESSEDIEKIYRELKNILESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1N7</accession>
    <name>A0A1V0N1N7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0073</name>
        <name evidence="3" type="ORF">HLB00_07340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141293.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1N7"/>
    <dbReference type="STRING" id="74969.FAD_0073"/>
    <dbReference type="GeneID" id="84218563"/>
    <dbReference type="KEGG" id="fai:FAD_0073"/>
    <dbReference type="OrthoDB" id="57538at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018646">
        <property type="entry name" value="12TM_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09847">
        <property type="entry name" value="12TM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="530" mass="60722" checksum="107FF779C06F0D90" modified="2017-06-07" version="1">MKNQTLFLSKLIMVEQRYLALKDTPKFQRSVNTINKQSYFTRNILMTYIANAILFTMIFVLLDSVYFEEKDTAALASFGLIVFLYLFIIGIYNSIVFFNSVYSNNIMAPLKSIPINVNVNVPFISWFIYNSSSYIFVVFPSAIFFYLLTDDYETIFLAIIYAFLVLMVSFIISSLLFIYSGKKAKTHTSIKNVIKILVLFLFLGAFYLLIEDPSYFGYVSSAIASLPYYVRIFAFPINLEYIVYLNYTLPLIYRIIEILLSLLFLVIVVFIYFALREKIYNILMTSEENESSEKVYSNIKGNKMLAAFLKKDAKSTFRKPQNLSYIFLPVLFVIPFFLGVGIGDGFSSSFFTLLYLVEFVSSFYAIFLLVVEGKGIEVLNSLPIKKQSIAFYKSIFGLIIFSVIAIAFTVVTIVISHKIGLIDLFELIDAITLFYIILTVNINRLLKKLPPGTSNLNYYSFGTYPMLFIFILSIILLGISVGLALGLSFLLFQSILYYAYTDLIINIIMLLFFIAKPKIFKNNENVINSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1T3</accession>
    <name>A0A1V0N1T3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
                <ecNumber evidence="13">2.3.1.234</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">tRNA threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="13">t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Serine/threonine-protein kinase Bud32</fullName>
                <ecNumber evidence="13">2.7.11.1</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_0134</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="13">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the N-terminal section; belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="13"/>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887140.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1T3"/>
    <dbReference type="STRING" id="74969.FAD_0134"/>
    <dbReference type="GeneID" id="16025279"/>
    <dbReference type="GeneID" id="31675646"/>
    <dbReference type="KEGG" id="fai:FAD_0134"/>
    <dbReference type="OrthoDB" id="6818at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24131">
        <property type="entry name" value="ASKHA_NBD_Kae1_arch_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000037">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01447">
        <property type="entry name" value="Kae1_Bud32_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009220">
        <property type="entry name" value="tRNA_threonyl_synthase/kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007174">
        <property type="entry name" value="PRK09605.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036401">
        <property type="entry name" value="Gcp_STYKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="14">
        <location>
            <begin position="24"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Kae1" evidence="13">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for kinase activity" evidence="13">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>L-threonylcarbamoyladenylate</name>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>L-threonylcarbamoyladenylate</name>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-threonylcarbamoyladenylate</name>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-threonylcarbamoyladenylate</name>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>L-threonylcarbamoyladenylate</name>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD84065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="531" mass="59617" checksum="0F31146529C3E342" modified="2017-06-07" version="1">MKVLGLEGTAHTISAGIVDDNRIISNFSSTYIPKNGGIHPREAAIHHADNILPVMKKAFEESGLSPGQINLVAFSMGPGLGPCLRVVATAARAFSIKYGIPLIGVNHPLGHVEIGRKLSGAKDPIMLYISGGNTQIIAHEENSYKVLGETMDIGLGNLLDKLARDVGIPFPGGPKIEEFALKGDKLLDLPYSVKGMDTSFSGIYTAARNYIGRESIENICYSVQETTFSMLVEVLERALYYTDKREILLAGGVARNDRLRSMVSHMAKSSGYVAYLTDKKYCMDNGAMIAQAGMLMYLSGQRQHIMDTKVNQSFRIDEVKVPWINSKKPVISNNRGAEALISESQFYGRKTITKQRVEKEYRNQELDRKIRTERMKNEFNLIFRLKSNGINSPILYDFDKYNFTLVMQKLDGITLNKLIRSGDNYMAVINKLGQIIGEMHNLLISHGDLNPNNIMVVGPDIYLIDPSMGKFNCEIEDMADDIFLLTESFKNLYSNYDVLENHFISSYKEKSTNYVEIIKTLDEIKQRRRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1U2</accession>
    <name>A0A1V0N1U2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887139.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1U2"/>
    <dbReference type="STRING" id="74969.FAD_0133"/>
    <dbReference type="GeneID" id="16025278"/>
    <dbReference type="KEGG" id="fai:FAD_0133"/>
    <dbReference type="OrthoDB" id="55723at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="entry name" value="IHF-like DNA-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="DNA-BINDING PROTEIN HU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175:SF3">
        <property type="entry name" value="DNA-BINDING PROTEIN HU-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="IHF-like DNA-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="90" mass="10106" checksum="E1F23D2B2D5CFCBA" modified="2017-06-07" version="1">MVGISELSKKVASTTNTTQKKTAEIITAFLKETVESVNAGNKVNLADFGIFERKEQKERVARNPKTREEIKVPAKDKFVFRASSAIKYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1W8</accession>
    <name>A0A1V0N1W8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA-processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887203.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1W8"/>
    <dbReference type="STRING" id="74969.FAD_0200"/>
    <dbReference type="GeneID" id="16025346"/>
    <dbReference type="KEGG" id="fai:FAD_0200"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22390">
        <property type="entry name" value="KH-I_Dim2p_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010331">
        <property type="entry name" value="PRK13763.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="185" mass="20643" checksum="85237FEFD65544B4" modified="2017-06-07" version="1">MLEIGNIKVPFARIGVLIGKEGTVKAKIEEEGKAKLDIDSENAIVTVYQKNDPLKALMALNVVQAIARGFNPEKAMLLFDDSVQLIVISIKEFVNKDAKRIKEIRGRLIGKEGHTREIIEELTGTYISISGNTVSILGDFISIQYAREAVNMILQGRKHKTVYSYLEKNVGELKFRKMEESFGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Z6</accession>
    <name>A0A1V0N1Z6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="11">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ubiA</name>
        <name evidence="11" type="synonym">ctaB</name>
        <name evidence="12" type="ORF">FAD_0218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141413.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Z6"/>
    <dbReference type="STRING" id="74969.FAD_0218"/>
    <dbReference type="GeneID" id="31675728"/>
    <dbReference type="KEGG" id="fai:FAD_0218"/>
    <dbReference type="OrthoDB" id="131615at2157"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003349">
        <property type="entry name" value="PRK04375.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="297" mass="33842" checksum="CD39841F4B43D49E" modified="2017-06-07" version="1">MSGKIALYIEYSKPRVWWLLVFIGFGGAILAINHFSLTNILMVIVAIVAITAGSMGAEGLTNYIDLEMDTTMERTRNRPLPSGKITMKGALIFGYSLAIFSVLILLVFGRFIASLFMAIGIVDNVFIYSYLLKKISSYSIIYGGFSGAFPVLIGWYAVTSTFSWLPWVLFLLVMFWIPVHVWSLAYRYREDYKKANVPMFPVTHSDRSTAIAISFSSLLLIVFSLTPYFLGLYNLVYLIPVAILSIPIIIFSYNFIKKPDRKTSFRLFVYTAPYLTFVFILVIILNLLRVLNLFRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N205</accession>
    <name>A0A1V0N205_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N205"/>
    <dbReference type="STRING" id="74969.FAD_0244"/>
    <dbReference type="KEGG" id="fai:FAD_0244"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19072">
        <property type="entry name" value="AKR_AKR3F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638:SF3">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638">
        <property type="entry name" value="OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="270" mass="30429" checksum="C209EDDA0D7D635C" modified="2017-06-07" version="1">MGINMVKLGNKEVSSIGLGTYGMGGKNSPDYKNDAKEVEAIKYAITNGINLIDTAEYYGHGHSEELVGKAIKDFEREDLFIISKVWPVNLHYKDVINSAKESLKRLDTDYIDLYLIHWPNPKIPVKETLGAMGELLDSHLIRNIGVSNFDIANLTEAIDQLKHGKIIANEVEYNLENYYIEDDLIPFCEKNNIKIIGYSPLNQGRISSKINHVAKSLGMSSIQCTLGYLKKKSIPIPKASSISHINELVECMNIDLDENEYNRIKEAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N239</accession>
    <name>A0A1V0N239_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0271</name>
        <name evidence="3" type="ORF">HLB00_06410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000223">
        <property type="protein sequence ID" value="NOL60464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887293.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N239"/>
    <dbReference type="STRING" id="74969.FAD_0271"/>
    <dbReference type="GeneID" id="16025438"/>
    <dbReference type="KEGG" id="fai:FAD_0271"/>
    <dbReference type="OrthoDB" id="56638at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="182" mass="19920" checksum="5244A07E0958B596" modified="2017-06-07" version="1">MKKYLPAIIVIISLVMVMAPFASSASPVTLPAAPTSLPSISYNYNGTNESISDSNWTAFFSSVIDNTHYVKYSFNTSTQCLIVYDLSYTGMNPYGLQFINALSGIGTPTLKNMTLAFNETKNMSSQVKGYTDIEALNAGAYPGFSFSKPVVKPLSTQYLYVGIFVAIIAGMIALYYVFNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N254</accession>
    <name>A0A1V0N254_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mov34/MPN/PAD-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0267</name>
        <name evidence="8" type="ORF">HLB00_06390</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000223">
        <property type="protein sequence ID" value="NOL60460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841630.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N254"/>
    <dbReference type="STRING" id="74969.FAD_0267"/>
    <dbReference type="GeneID" id="16025434"/>
    <dbReference type="KEGG" id="fai:FAD_0267"/>
    <dbReference type="OrthoDB" id="4612at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08072">
        <property type="entry name" value="MPN_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="120" mass="13498" checksum="001835E5593E46A5" modified="2017-06-07" version="1">MWSIRERTLKMIMEASRDALPNEFGALLRAEHQIIYEIALVPGSINGPVHVIFRTYTMPLDFSYVGSVHSHPSGNTHPSDADLHMFSNTGPVHIIVGYPYNMNNFSAYTRNGDPLKLNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N258</accession>
    <name>A0A1V0N258_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N258"/>
    <dbReference type="STRING" id="74969.FAD_0252"/>
    <dbReference type="KEGG" id="fai:FAD_0252"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="132" mass="15783" checksum="218E016552FC3F35" modified="2017-06-07" version="1">MNSNVLYHFLRKIRRTETFILWDVITVHMTVRPKKVTRKDGNTYYSLVDEKRVKGKVVQKYVGYLGKDLHSKNEIKLEDILPYIKRLLDKKISQEDIDSILKKIGIEYDSWPITKIMIENDLKLKKTFLRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N270</accession>
    <name>A0A1V0N270_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0328</name>
        <name evidence="2" type="ORF">HLB00_02015</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000053">
        <property type="protein sequence ID" value="NOL59610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887346.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N270"/>
    <dbReference type="STRING" id="74969.FAD_0328"/>
    <dbReference type="GeneID" id="16025492"/>
    <dbReference type="KEGG" id="fai:FAD_0328"/>
    <dbReference type="OrthoDB" id="57373at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="96" mass="10809" checksum="E05BAE3EC3F49B9C" modified="2017-06-07" version="1">MFKLYKLPKEDRGIIDALLADDVVGRQTITYKDGVNYGYDSSYIVLIEGPEDIFKNVETIASGKLEPLGKSKQEDIYKKIKDEENNSQNGLGFIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2B7</accession>
    <name>A0A1V0N2B7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141505.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2B7"/>
    <dbReference type="STRING" id="74969.FAD_0325"/>
    <dbReference type="GeneID" id="31675834"/>
    <dbReference type="KEGG" id="fai:FAD_0325"/>
    <dbReference type="OrthoDB" id="85443at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16099">
        <property type="entry name" value="TenA_PqqC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050967">
        <property type="entry name" value="Thiamine_Salvage_TenA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198">
        <property type="entry name" value="BIFUNCTIONAL TH2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198:SF2">
        <property type="entry name" value="SI:CH1073-67J19.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="204" mass="24509" checksum="2ACD8C9C28151F71" modified="2017-06-07" version="1">MYLRSYLNSPEVMELIDHIVHSDFVKSMKDGTIEDERFRYYLKQDHIYLKYYKAAGDVIGKNTGDDNIRELYNEIGSEEPEFHRNMLKQFGIDEAGIKESEINYTTYSYINHLLRWSKDSSINGMLSMFPCQWSYGYIAEATAAPSEKYLFWFDFYRSKDYRSITDKYLEILQKEPLSTYQEQIIKFGLEYELNYWKECYIEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2B9</accession>
    <name>A0A1V0N2B9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0352</name>
        <name evidence="3" type="ORF">HLB00_01485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000040">
        <property type="protein sequence ID" value="NOL59510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887371.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2B9"/>
    <dbReference type="STRING" id="74969.FAD_0352"/>
    <dbReference type="GeneID" id="16025517"/>
    <dbReference type="KEGG" id="fai:FAD_0352"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011465">
        <property type="entry name" value="PRK14886.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="140" mass="16345" checksum="3ADF0093B1FE61ED" modified="2017-06-07" version="1">MLHDLQYFILKYYNNKIFDYLKTRTSLIQLIDGNSISSELELSEAIRKTDRYLEHNGKIHFPGTVLLMYLAHTNQINVAINRCGINPDTQSGVVVYSNREDLDFLIEGGYIKLTERFIPYDLPRKDFEVFSSMARLETMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2K5</accession>
    <name>A0A1V0N2K5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA primase large subunit PriL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">priL</name>
        <name evidence="9" type="ORF">FAD_0410</name>
        <name evidence="10" type="ORF">HLB00_05015</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141577.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2K5"/>
    <dbReference type="STRING" id="74969.FAD_0410"/>
    <dbReference type="GeneID" id="84218921"/>
    <dbReference type="KEGG" id="fai:FAD_0410"/>
    <dbReference type="OrthoDB" id="46081at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06560">
        <property type="entry name" value="PriL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00701">
        <property type="entry name" value="DNA_primase_lrg_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023642">
        <property type="entry name" value="DNA_primase_lsu_PriL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140914">
        <property type="entry name" value="PriB N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="8">
        <location>
            <begin position="216"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL60196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="337" mass="38965" checksum="37FF1844984B3124" modified="2017-06-07" version="1">MITSNFFVDFKLIENVDAIDGIVNSLVPENRSSVREAFEYLNGVVRKYADNEGYNITMGKNAFAIAMWMLRYINEPGMTSRFAITQRDVFERELNRISKEDNENIIFYCDSAGIEATVDGNTFHIPFDFFIKNNKKISGFKYRLVYQKLSRGTIYLSKNQFIHLLREDFVQKLMDVYSRMGPGDSQNIFRKFIGDLEKIKKDFLEIKSKNTISLGEVDFTMFPPCIKTYITQMRDGENLAHLARFTLASFLHSAGMSNENMLNLFKFAPDYKEDLATYQVNHITGVISGTEYSPPKCSTLRSNHLCYMGDDPLCARIKHPMQYYEAKKKSSGNYRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2N3</accession>
    <name>A0A1V0N2N3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2250 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0433</name>
        <name evidence="2" type="ORF">HLB00_06945</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000248">
        <property type="protein sequence ID" value="NOL60565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141590.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2N3"/>
    <dbReference type="STRING" id="74969.FAD_0433"/>
    <dbReference type="GeneID" id="84217018"/>
    <dbReference type="KEGG" id="fai:FAD_0433"/>
    <dbReference type="OrthoDB" id="45652at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019254">
        <property type="entry name" value="DUF2250"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10007">
        <property type="entry name" value="DUF2250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="163" mass="19505" checksum="59F8F96CD06BE6F6" modified="2017-06-07" version="1">MEDAEIKKKLAMDHQMLMVLEHFQLAKLDYAKNVKIYTSIPQENVEIYIERLYSMELLEKYSGSSVKRTQAKLKKTNEVHKHHTYYELTNKGHYILKDMTEREYIKYLQVECLKLLVLKRLRKENREKCAKLYDMGLMDKNYEPTSMGLAVVDLARRRQIKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2N5</accession>
    <name>A0A1V0N2N5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887545.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2N5"/>
    <dbReference type="STRING" id="74969.FAD_0489"/>
    <dbReference type="GeneID" id="16025692"/>
    <dbReference type="GeneID" id="31675998"/>
    <dbReference type="KEGG" id="fai:FAD_0489"/>
    <dbReference type="OrthoDB" id="56476at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="297" mass="34537" checksum="BE74B90BCCEB3A23" modified="2017-06-07" version="1">MESYEVKEMPISYSREIKLSFCAVADEISDQMKKSLESIINVAEEIGYPYELVITTHIPVDVKSDKIKFINEAFTTPGAGKQLAYIHSNGNYLIIFNPYNIYSPETSDVVHSFLEKREKRALIYNLIVISRDLLDKTGGWRDLREYEDIDLLARIAAEGGIVAFPAERYDSLLYRVPDKESFIDRFLNFRDAIISCNFGLKDIKIFHIEPFYVSFISLLLSKLSRTKPYKFKENNRIIVMEGIMESLILKDFENYFIPVTIPKLHISSTELNYMEKRSYLWNKVNKSIMEIIQVSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2P5</accession>
    <name>A0A1V0N2P5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium-transporting ATPase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_0516</name>
        <name evidence="12" type="ORF">HLB00_00535</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000014">
        <property type="protein sequence ID" value="NOL59326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887574.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2P5"/>
    <dbReference type="STRING" id="74969.FAD_0516"/>
    <dbReference type="GeneID" id="16025720"/>
    <dbReference type="KEGG" id="fai:FAD_0516"/>
    <dbReference type="OrthoDB" id="8035at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE C CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042:SF2">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE KDPC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL59326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="158" mass="17233" checksum="45DE1C947368B567" modified="2017-06-07" version="1">MKTKKMISSSLRMAVILVLICGLLYPAVVTGIGQGVFPYQANGELAKLDNTTVGSYLIGQSTNNSQYLFNVRNNSASGVDPDITVASALIQAQVIHNATNISLSYLDGLIHNNTRHTLFFFGTAYVNALKLDIQIIDEFHSKIAVYNKIYNNVCKTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Q1</accession>
    <name>A0A1V0N2Q1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141613.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Q1"/>
    <dbReference type="STRING" id="74969.FAD_0454"/>
    <dbReference type="GeneID" id="31675963"/>
    <dbReference type="KEGG" id="fai:FAD_0454"/>
    <dbReference type="OrthoDB" id="91412at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058836">
        <property type="entry name" value="DUF8183_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058496">
        <property type="entry name" value="DUF8183_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26556">
        <property type="entry name" value="DUF8183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26555">
        <property type="entry name" value="HTH_78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8183" evidence="2">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8183" evidence="1">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="202" mass="22681" checksum="7285EE5531C38EF8" modified="2017-06-07" version="1">MVTLDDILKWLSSGTDNASSLIDLKWNIKKVGNYIALENNKIPFDILLYADDQKKSCSLIVRTGIETATIENQPRLTIYRTLLLLNQKVEMVKFMLDGINEEVVAREDFDLSVLTKDVLNTGLNTILAAFYLMVKALNMEDEFNSGVIERTAMMIKEMASAGKTKEEIKDYLVSSLGLNENDANKLISEVLSADSAPKNMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Q2</accession>
    <name>A0A1V0N2Q2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2 8">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">asnS</name>
        <name evidence="10" type="ORF">FAD_0462</name>
        <name evidence="11" type="ORF">HLB00_09995</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2 8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000442">
        <property type="protein sequence ID" value="NOL61148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141616.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Q2"/>
    <dbReference type="STRING" id="74969.FAD_0462"/>
    <dbReference type="GeneID" id="31675971"/>
    <dbReference type="KEGG" id="fai:FAD_0462"/>
    <dbReference type="OrthoDB" id="5908at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="130"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL61148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="429" mass="50031" checksum="E34F547886F1C5A7" modified="2017-06-07" version="1">MEKIKEALSDDLLGKTVSIRGWVYRIRSSGKITFIVMRDSTGIIQCIASSENLNDEQMKEISSLTIESSIELSGKLRKEPRAVTGYEISLQSYKIYERNENFPIAKDLGEEFLLDNRHLWLRSREFTAVLKIRSTVFKAFADYFYKEDYYQVQAPMFVSTATEGGSSLFNVDYFGEKVNLTQSSQFYLETLIYSLEKVFTIAPSFRAEKSRTRRHLTEYWHAEGEAAWYSNEDMMADEEKMIKYIIDEVLKNNLEDLEIIKRDINKIKNIKIPFERIKYKDLIEKSKEFGMNLKYGDDLGADEEYGIMVHFDNPIFVTDYPESLKTFYHRPDPDNPGEILCHDLLAPEGYGEVLGGGERIYDLQQLLDRIKENNLNPEDYYWYVDLRKYGSIPHSGFGLGLDRLVMWICGLSNVRETIPYPRTIRRVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2U8</accession>
    <name>A0A1V0N2U8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N2-acetyl-alpha-aminoadipate semialdehyde transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysJ</name>
        <name evidence="6" type="ORF">FAD_0507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141642.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2U8"/>
    <dbReference type="STRING" id="74969.FAD_0507"/>
    <dbReference type="GeneID" id="31676015"/>
    <dbReference type="KEGG" id="fai:FAD_0507"/>
    <dbReference type="OrthoDB" id="85346at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="393" mass="43230" checksum="E64380108E8E56F8" modified="2017-06-07" version="1">MNYENEHIANTYQRLPVNVLNGNGAILHDINGKRYIDMMGGYGVAILGYGNKKIKEAVCRQFDTIPIAHASEYTAAREEFIKNLTGIVPAGLDKFYLGNTGAEAIEAAIKVVIKSSKNHKIIAMTNSYHGKTAGALSITYSEKYRQSFGDLLIKNVEFIRYNNMEDLDKIRKDNDISAVFFEPVQGEGGINIPDREYVRELRQITEDKGIILVADEIQSGLGRTGKMWAHEHFGIKPDIITIGKGIGGGIPLSVTAGKPEFMDNLAKGEQSSTTGGNPIAMASGSAVIEQLTDDLINEVAVKGELFRNTLKEYLADSRIVKEIRGLGLMDAIELRVKFLPVFMDIINRGVLPLYSGINILRMLPPYVISNAEITEAAKIMSEGIKSYNKEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Z0</accession>
    <name>A0A1V0N2Z0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Z0"/>
    <dbReference type="STRING" id="74969.FAD_0553"/>
    <dbReference type="KEGG" id="fai:FAD_0553"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="53" mass="6461" checksum="467283BA24A5DF29" modified="2017-06-07" version="1">MRIFIFILIFNYPDLCGYYYTSYIDLKTKPLNYWGDTQTQIINNRIRILTGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Z9</accession>
    <name>A0A1V0N2Z9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9 10">DNA repair and recombination protein RadB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">radB</name>
        <name evidence="12" type="ORF">FAD_0559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic RecA-like protein family. RadB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940599.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Z9"/>
    <dbReference type="STRING" id="74969.FAD_0559"/>
    <dbReference type="GeneID" id="84217158"/>
    <dbReference type="KEGG" id="fai:FAD_0559"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00350">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011939">
        <property type="entry name" value="DNA_repair_and_recomb_RadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02237">
        <property type="entry name" value="recomb_radB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF47">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RADB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003336">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="11">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="NCBIfam" id="TIGR02237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="236" mass="26532" checksum="98D73076723CE69B" modified="2017-06-07" version="1">MEKIKLNESEYKTMSGYPCIDKLMEGGLEPGIITEFYGEGGAGKSNLAMIYSISALKNGNSAIYIDSEGFSVERFRSIANGDMELINHMNIYRVKSLDDQYLALIKSDKLIGEKRESKNSFGIMVVDSFTNFFRMEAGKDASARMEGYEKQLNILSGIALKYKIPVVITNQIYEDVNNSTLEPFGGFFIDHAMKAIYRIEKLSGGMRRITVEKHRSIREGSYTGFRIVDSGIECEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N315</accession>
    <name>A0A1V0N315_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141733.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N315"/>
    <dbReference type="STRING" id="74969.FAD_0631"/>
    <dbReference type="GeneID" id="31676136"/>
    <dbReference type="KEGG" id="fai:FAD_0631"/>
    <dbReference type="OrthoDB" id="55835at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="81" mass="9540" checksum="E20CFF4494733F83" modified="2017-06-07" version="1">MNYLNCFNNINTADEAAEAIHCIQKCGETVLYNDKEKRLVLWREAYDKSPEEHMIKISKLLKIDSRESYEAADKTYNLTMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N329</accession>
    <name>A0A1V0N329_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta fold family hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0564</name>
        <name evidence="6" type="ORF">HLB00_00670</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. ABHD14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000018">
        <property type="protein sequence ID" value="NOL59352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148285793.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N329"/>
    <dbReference type="STRING" id="74969.FAD_0564"/>
    <dbReference type="GeneID" id="84217163"/>
    <dbReference type="KEGG" id="fai:FAD_0564"/>
    <dbReference type="OrthoDB" id="7531at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197">
        <property type="entry name" value="PROTEIN ABHD14B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="204" mass="22428" checksum="C398FC04EC39DD51" modified="2017-06-07" version="1">MEVKENKVDIGGKSVYYISYERGNMRNFILLHDSTTTSNSWAGIDALRKIGQWGFNVYAPDFPGFGNSEANDSYNFGSSPSKGALFIKDFAESLFLSSINVVGPSVSAGVALKSLIDYPELINSSIIIGGLGVDHILNELNRIDKPVLILWGSRDNVVPVSHGLRYHDLIPSSTFVKINGAGHCVQIEKPDIFFNNIKKFITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N333</accession>
    <name>A0A1V0N333_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0603</name>
        <name evidence="11" type="ORF">HLB00_10110</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000443">
        <property type="protein sequence ID" value="NOL61171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N333"/>
    <dbReference type="STRING" id="74969.FAD_0603"/>
    <dbReference type="KEGG" id="fai:FAD_0603"/>
    <dbReference type="OrthoDB" id="27596at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL61171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="360" mass="41837" checksum="17B09E27CB150E1F" modified="2017-06-07" version="1">MIILLILLIFYTVLLLLISSGFIYIESHKYHSEHIVNNYRPETLVIMPVRGIDYSLEKNLISVKNQEYENFKFLCVVDSEEEEALKVIKKLDIEYITSSYKCDKCSGKVRAISTAIQLYNNYEVYLLADSDIEVKKNWILNMVMPLNQEDAGLSTTFPYFYPKNGFWAQIKEIWGFVGMGLMESKLTRFGWGGSLAFKHELISDSLEFFSEHVSDDTALTKICKQKGKKIYYVDSAQPDINSPDTFKVFAEWANRQTALSISASPKVYYYGLLFYGAYLFLFFSAILMGVFYNPLYFLFLIPAVMYIYNMVRRLKHIKPVNILGSIILPFIYMTNLIVAKRMKKITWRGNTYDIEDKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N346</accession>
    <name>A0A1V0N346_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Elongation factor 1-beta</fullName>
            <shortName evidence="6">EF-1-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">aEF-1beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ef1b</name>
        <name evidence="8" type="ORF">FAD_0604</name>
        <name evidence="9" type="ORF">HLB00_10115</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000443">
        <property type="protein sequence ID" value="NOL61172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887661.1">
        <property type="nucleotide sequence ID" value="NZ_JABGBP010000443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N346"/>
    <dbReference type="STRING" id="74969.FAD_0604"/>
    <dbReference type="KEGG" id="fai:FAD_0604"/>
    <dbReference type="OrthoDB" id="84643at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00043">
        <property type="entry name" value="EF1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004542">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00489">
        <property type="entry name" value="aEF-1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001670">
        <property type="entry name" value="PRK00435.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006521">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL61172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="88" mass="9601" checksum="E6C0A522C1D58A56" modified="2017-06-07" version="1">MGDVMVQLRILPESVDVNLKDLRVAITASIEKLCTINEVKEEEIGFGLSALLFSVIVPDEEGKIDSVENAISSVKNVSQVDTRDVTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N351</accession>
    <name>A0A1V0N351_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coenzyme PQQ synthesis protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141787.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N351"/>
    <dbReference type="STRING" id="74969.FAD_0683"/>
    <dbReference type="GeneID" id="31676184"/>
    <dbReference type="KEGG" id="fai:FAD_0683"/>
    <dbReference type="OrthoDB" id="30736at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21123">
        <property type="entry name" value="SPASM_MftC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050377">
        <property type="entry name" value="Radical_SAM_PqqE_MftC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04053">
        <property type="entry name" value="TIGR04053 family radical SAM/SPASM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228:SF34">
        <property type="entry name" value="TUNGSTEN-CONTAINING ALDEHYDE FERREDOXIN OXIDOREDUCTASE COFACTOR MODIFYING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="365" mass="41401" checksum="9DE5488EDD45A7E3" modified="2017-06-07" version="1">MINYNEKPILIFWETTKACGLACRHCRASALEKPLPDEMNFEEATAFIKSIRDFGKPYPILILTGGDMMRRNDINKIIETANEYEIPVSISPAATDLLTPERIDYFKAHHVLSASLSLDGNREMHDWLRGDGVYNKTVDLIKLLNAKNMKLQINSVVMRKNIHQLPSLLKLLIDNNVKTWEVFFLIQTGRAIDSEDLTPVEFEDINHWLLFATKYGIVIRTVESPIFRRVMDEGNENYSGDLYYELMDQTVDILGLPDSRNPPQGTSNTRDGKGIIFVGHNGDVEPSGFLTYKLGNVKQNSIVDIYRNNETLKMLRNSKNFGGRCGICNWGDSCGGSRSRAYARYGDIFARDPACLYSELPESLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N356</accession>
    <name>A0A1V0N356_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887672.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N356"/>
    <dbReference type="STRING" id="74969.FAD_0614"/>
    <dbReference type="GeneID" id="16025821"/>
    <dbReference type="KEGG" id="fai:FAD_0614"/>
    <dbReference type="OrthoDB" id="10510at2157"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="7">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="164" mass="18358" checksum="CEC04C0107547843" modified="2017-06-07" version="1">MIFNIKITGKKVLFAGGGKIAEAKIKKLIKESPEISVIAPEVTEYIRTLGKGGKINIIEREIRIDDITENYFLVICATSNQGLNRKISIECRKLGILHDDLSNHRNSDIMMVASTIIGNLTLSISTDGMAPAIARRLKTELEEDLIHNSNNFEEDIKTIYNKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N380</accession>
    <name>A0A1V0N380_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidylyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0648</name>
        <name evidence="3" type="ORF">HLB00_03625</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000115">
        <property type="protein sequence ID" value="NOL59923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141748.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N380"/>
    <dbReference type="STRING" id="74969.FAD_0648"/>
    <dbReference type="GeneID" id="84217250"/>
    <dbReference type="KEGG" id="fai:FAD_0648"/>
    <dbReference type="OrthoDB" id="57544at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="314" mass="35771" checksum="38D4DC159785B814" modified="2017-06-07" version="1">MELFNFAYLAVFIIAVSYILIKNRETFLIKILVSIPIMVGLVYFSGSFFVLPVYLFSMIVSTYLYTVFFYFPFAVDFVLIILSIFGNFVPVRFVFASISISILLSMFLDKNMRKYDVTNNENKGKDIQRETSRDYFQISTGVITIAIFALDGIKGRILILLAILLIYLGGNILYLNNRNRLADLVYMMERKDTKLGLGSMYLAAGFLFVLSFTRSLQLIYISAFLIMIGDSLATIIGMKIRSRKLFYNRRKSMAGFLGMLIPSFLFGLFFFVYFISAFYAIGGTFAESISNKIADDNITIPVSIVIIHFIISMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N384</accession>
    <name>A0A1V0N384_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0706</name>
        <name evidence="2" type="ORF">HLB00_02795</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000090">
        <property type="protein sequence ID" value="NOL59762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141817.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N384"/>
    <dbReference type="GeneID" id="84217329"/>
    <dbReference type="KEGG" id="fai:FAD_0706"/>
    <dbReference type="OrthoDB" id="57242at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="104" mass="12424" checksum="17C109052BD22ED5" modified="2017-06-07" version="1">MIIASISFREGKLEESDSRSSMELEDIKKTLAYAFLYDFTVNVYTDREEYKFLSIMSIKYNDKGNLFFSGVYLHNNLRVRKNFSWREIRNVNVNIEKDPEKSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3C9</accession>
    <name>A0A1V0N3C9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141820.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3C9"/>
    <dbReference type="STRING" id="74969.FAD_0708"/>
    <dbReference type="GeneID" id="31676210"/>
    <dbReference type="KEGG" id="fai:FAD_0708"/>
    <dbReference type="OrthoDB" id="275427at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19072">
        <property type="entry name" value="AKR_AKR3F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638:SF3">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638">
        <property type="entry name" value="OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="270" mass="31034" checksum="00D7C38A70933BFB" modified="2017-06-07" version="1">MIYREFGNTSFKTSTIGMGTYYDMRWIFKTYLGIYSGKDQKIDAYRAGIDNGINLIDTAELYRTEKLVGTAIKSYKRDELFIATKVFPTHLSPKSLEKALNRSLKNLDTDYIDLYQIHFPNPAVDLKKTMRTMEKMIDTGKMRHIGVSNFTLNLLKRAQGILSKYEITSIQINYNVFHRNSQKAMIDYCNKNHIAVMAYFPLGHGKVTQPQFNKYFDHVRKTIGDVPNANIALAYLISRNQNVFPIPRASNRAHVLQNAKNSDILLNLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3D4</accession>
    <name>A0A1V0N3D4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ChsH2 rubredoxin-like zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141806.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3D4"/>
    <dbReference type="STRING" id="74969.FAD_0699"/>
    <dbReference type="GeneID" id="84217322"/>
    <dbReference type="KEGG" id="fai:FAD_0699"/>
    <dbReference type="OrthoDB" id="9573at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="ChsH2_Znr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052513">
        <property type="entry name" value="Thioester_dehydratase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34075">
        <property type="entry name" value="BLR3430 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34075:SF5">
        <property type="entry name" value="BLR3430 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="zf-ChsH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChsH2 rubredoxin-like zinc ribbon" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="112" mass="12857" checksum="E3E890AE3433C168" modified="2017-06-07" version="1">MKLDEIYEEYNKHFSIGILPYTKCMNCGKVYYYPRDSCPVCGKGDLKIMQSTGHGTVYSYTKFNNGFYGIISFSEGFRAYMDISGNNPGIGMEVEIKFKKIKDNLLPYAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3H9</accession>
    <name>A0A1V0N3H9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="7">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="7">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pdxT</name>
        <name evidence="10" type="ORF">FAD_0720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="7"/>
    <dbReference type="EC" id="3.5.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141844.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3H9"/>
    <dbReference type="STRING" id="74969.FAD_0720"/>
    <dbReference type="GeneID" id="84217343"/>
    <dbReference type="KEGG" id="fai:FAD_0720"/>
    <dbReference type="OrthoDB" id="26717at2157"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000010">
        <property type="entry name" value="uncharacterized protein LOC100176842 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="7 8">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="190" mass="20478" checksum="3766DFFABC63DB2A" modified="2017-06-07" version="1">MKIGILDIQGDVSEHFQMIKRLPGKYHAVPVMVKTVNDLAGISGLIIPGGESTVIYMLLKKSGMYEKIVEMAHSGLHIMGTCAGAILVSRDTGDKQVEGMNLIDISIKRNAYGRQINSFIQKINISGIGNFDAVFIRAPEIESTGNSEVLGLENGKPVIVREGNIMALTFHPELTGNTGVHELFVSGITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3J3</accession>
    <name>A0A1V0N3J3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">APC family permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0830</name>
        <name evidence="8" type="ORF">HLB00_05160</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000175">
        <property type="protein sequence ID" value="NOL60223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142034.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3J3"/>
    <dbReference type="STRING" id="74969.FAD_0830"/>
    <dbReference type="GeneID" id="84217451"/>
    <dbReference type="KEGG" id="fai:FAD_0830"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="46"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="503" mass="54489" checksum="BCA1685FFC7FA1DE" modified="2017-06-07" version="1">MIKEEVFRPKKEYKHLGYNQLSLRHAVSQAVGLNAPGGTIVLYVAGTAALLTFTFSKYPDGAFSIPLILLLALIVYSMMSYSSFEFSKYLSSSGGYYTFVANGLGKGFGLTTALSYISYQILSFTGFGILGFIGFAYAILPSLGITVPYVNILWIPVTIVFILFVSFLIYKGIKPSLKYVSYAILIEVIFFIASSVYLIGVNHTSISIKPFTAIPVGGNFIVLAAMMVYAIGSFVGVGGSIPIAEETKNPKKTVPRSIIASIAILGVTIIIAAYAEVISWGYGNMVSFGTGTGIGAYPVLSIYKDGFSGMGLIPFAVLLIIVINSFFTATVSLGTNASRVIFSLSREGVIPEKLSRTNTKGVPVYAILFITIVSLAIVLATGISFELLYPGKIIDALLYSSVFLLVLESPISYIVHILTNTSLHMYLKKRKMKTHIFRHIIIPGISSITLVGAIIAAVYFDLSAPYIYGVYGALVWVIVIAIVVVIMYTKYNKNLDDIGNFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3P4</accession>
    <name>A0A1V0N3P4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyl transferase AbiEii/AbiGii toxin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="ARD84734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="29440" checksum="A9F18FA3DDAC545A" modified="2017-06-07" version="1">MIDKDDIIKLSKLHGLRPWQEEKRYMLSVVLNAIYNEPLIFKGGTYLWLFHGLRRFSEDLDFTENSMLKGNLPDKVSEELKLQGINNELKIVKNDNITLSFRLLSEGPLYTNILSMVPVYVEISRREKIIKQAMALNFDFPEYNLPIRILSGMNLDEVAAEKVRAIYTRKKARDIYDLYYLIYFKKVIFDPELINMKLKFYNIIFDKMEFINEILKQEKIFSNELKPIVMGEIPEIQKIIEIVSSWINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3R8</accession>
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    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
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            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="359563at2157"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0015074">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Integrase_cat-core"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSPOSASE INSO FOR INSERTION SEQUENCE ELEMENT IS911B-RELATED"/>
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    </dbReference>
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    </dbReference>
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            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="303" mass="35660" checksum="62EDB76BC7F1D99E" modified="2017-06-07" version="1">MAYEYINKGLRISKVANMLNIPRCRFYRNKVTDKNNNKSIKKGRKNSEFTLRKDGDSTVVMDNSTVVNNIKELLSGEFVCYGYKKTAKYLNRHGYIINKKKVRRLMSENNLLNYPYNNRKPATRVINTIVKVNNTNQVWEFDIKYVYINGESRNTYLLAMIDCYTREVVGHYLGCHCTGNDVKNTMIEAFDKRGINNISGIRMRSDNGTQFISNIVEDFLSMMNIYHERIHPATPKEDGYIESFNSILEREVIRRFEFDNIEEARSTIKRYIDFYNNERLHSAIGYITPKEMNIKCMEMKQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3V8</accession>
    <name>A0A1V0N3V8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VapB-type antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3V8"/>
    <dbReference type="STRING" id="74969.FAD_0959"/>
    <dbReference type="GeneID" id="31676460"/>
    <dbReference type="KEGG" id="fai:FAD_0959"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009956">
        <property type="entry name" value="Post-segregation_anti-tox_CcdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07362">
        <property type="entry name" value="CcdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="76" mass="9197" checksum="0AD71472014A5666" modified="2017-06-07" version="1">MSKMVSIRIDEDTLSEAKKLNINISKVLRELLKKEIEKRENIERLESLSKIQEILKNVDKKQLLEDLRRDRDERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3X7</accession>
    <name>A0A1V0N3X7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940549.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3X7"/>
    <dbReference type="STRING" id="74969.FAD_0979"/>
    <dbReference type="GeneID" id="31676478"/>
    <dbReference type="KEGG" id="fai:FAD_0979"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="19"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="412" mass="46118" checksum="431AA111EA77B8AF" modified="2017-06-07" version="1">MDNFNKLDTGKIGFQQKKLFTLSSMGIFLDGYDLSIITMAILVIPAQLDFTKMEYILVDISSFVGMLIGAPVLGLLSDRIGRKKIFGLDLIFFVVFAITAGLSNNFIELFLSRFLMGIGIGGDYPISSTMMAEFSPKKSRGKLLISMVGMYWLGAFVSSFVNYIFVVNAYFWRYTFIIGGLIAIPVILLRFKIPESPRWLLSKEKDYKKYNKKSPKFYTMLIFVLLAWFVFDVAAYGLGFYYPVIFSALGFKDQFRQIAEISMLISVGGISGYLIALPLADKLGRRFLIIGGFFIMSVLLILGSVIKITGLYAVPFYFLFVLFEQWVGAVTLFYPTEIFDTSIRSSVQGLATSVSRVGAIMGIVLFPLFPIFKSLSIFAAFSVLGLFVVIFLAPETKNKSLEQNVEAYTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3X9</accession>
    <name>A0A1V0N3X9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142277.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3X9"/>
    <dbReference type="STRING" id="74969.FAD_0981"/>
    <dbReference type="GeneID" id="31676480"/>
    <dbReference type="KEGG" id="fai:FAD_0981"/>
    <dbReference type="OrthoDB" id="193284at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016878">
        <property type="term" value="F:acid-thiol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006182">
        <property type="entry name" value="PRK08316.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF1">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="466"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="560" mass="64028" checksum="D79BCE320636AD3D" modified="2017-06-07" version="1">MEIDRKEKTNSIPDEFFNITEDNIKKLRNRHNKIRRWVIADFLKRNACRYPEKAALIFNHPGKGEIKLTYPELEANSNRAANAFLNLGIQKYDRIAILAHNTLHHVLTIFGAAKAGGIYLALNYLMSGKDLAYCINHSEAKVLIVEDSLYDKIKGVLGDLKTVKTFIWSNQGLNDPPPDNKWLNFDELHETFSSEEPDIILNIEDPVTFTYTSGTEALPKAVVLSNESLISEYVGAIIDGKYNSDDINLNPMPIFHVAQRDVFVMPIFYIGGTNIMLTNPNPENILWYVDRYKPTILFLAPTVWISLLRYPDFDKYDFSSLTKCYYGASIFPEEPLKELMKKLPQARFYNYYGQTELAPYHTVANHEDILRLPKTAGRSGLNMQTRIEDANHNEIIEPGIPGEVTGRGAHVMLMYFKDPEKTEETFKHGWFHTGDIGFMGNDRYLEIADRKKDMIKTGGENVSSREVEEAIFKHPDISEVTVIGLPHRRWVEAVTAIVVPKPERTINPDEVIELCRKELSPFKVPKAVIVIKPDELPKSPSGKILKRDLRNTFANYYETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Z4</accession>
    <name>A0A1V0N3Z4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0917</name>
        <name evidence="3" type="ORF">HLB00_04075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000136">
        <property type="protein sequence ID" value="NOL60011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142182.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Z4"/>
    <dbReference type="GeneID" id="84217482"/>
    <dbReference type="KEGG" id="fai:FAD_0917"/>
    <dbReference type="OrthoDB" id="40412at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05403">
        <property type="entry name" value="NT_KNTase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37030">
        <property type="entry name" value="NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37030:SF3">
        <property type="entry name" value="POLYMERASE NUCLEOTIDYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="104" mass="12131" checksum="AE36D1366ECDFACF" modified="2017-06-07" version="1">MSIEYELKKLNYLKNYREACKEVYRLVKNIDNNARVFVFGSVLTGNTTASSDIDILVLESNKDLKDEINIKVLKYIDAPVELHIVDNNGLDWYKRFSDNIEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Z7</accession>
    <name>A0A1V0N3Z7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN-domain RNase, VapC-type toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Z7"/>
    <dbReference type="STRING" id="74969.FAD_0992"/>
    <dbReference type="KEGG" id="fai:FAD_0992"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39664">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39664:SF2">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN, CONTAINING PIN DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="123" mass="14503" checksum="6362B1607E9B8195" modified="2017-06-07" version="1">MKLEEAVFDTNVIIAIIIENDINHKKALELWKKIDKAYVPMISVIEFNYFLIKHSLPVAITKELINDEKVNIIPTQKDDVFFSIKSNIKSYDDFNDMIILNISKRIKKQLITFDVELKKLYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N438</accession>
    <name>A0A1V0N438_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142385.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N438"/>
    <dbReference type="GeneID" id="31676531"/>
    <dbReference type="KEGG" id="fai:FAD_1032"/>
    <dbReference type="OrthoDB" id="36362at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="2">
        <location>
            <begin position="235"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="616" mass="71619" checksum="9E8BC0E20B00D532" modified="2017-06-07" version="1">MVVTSNVTNSPEETNNNYLKIQNHGIIFNNRTAALIGADGTIDWACFPNFNSVPIFDSILDYKKGGYLMLKPLCNTTINQYYEEFTNILITEFIKDNNIILKLTDFLPASKFSTTNFPEIHRFVEALDDVTIKLYFKPSFNYGQEIPSIEKDKNGYLFHRTERNVGISTNFRLNKNKTMVYNDNIKLNKGSFQWIVISTDINHLSNVDEYKSYKLLEYTRNYWKNWSNTIYYQGLYHKYIVRSALVLKGLFYEPTGMMVAAPTSSLPESIGGERNWDYRFTWIRDTAYVIEALSLIRLNDEATKFLYDLLDRINRDQKLRTIYSIDDSDTTDEKIINYSGYMNSGPVRVGNKAVDQLQLDQFGSIINAIYQFNLAGGMVTIQLWDFVLSILNSLKPIWKYPDSSIWEFRTEPKQYVYSKIISWTAFHEAIIMGKTLGYSAPYNEWKQIENEIKNDILKNGFNSEINSFTQYYGSTNVDASLLRIPLTDFLPVNDYRITGTLKKIETDLMHNNYLFKRYNEDDGLKGDDNAFLLLSFWYIEDLIKMKKIKEAKNALETVLNLSNHLMLFSEEIDLQTHDFLGNFPQAITHLGVIRAIVKLNEQFSNTQKSPVFNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4B3</accession>
    <name>A0A1V0N4B3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142431.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4B3"/>
    <dbReference type="STRING" id="74969.FAD_1063"/>
    <dbReference type="GeneID" id="84217662"/>
    <dbReference type="KEGG" id="fai:FAD_1063"/>
    <dbReference type="OrthoDB" id="56830at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916:SF3">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="304" mass="35556" checksum="B271E1190F57CDE9" modified="2017-06-07" version="1">MEKSNNYISVIITAYNRRQYVLDALKSSTEQSLSRQLYEIIIVKNFKDTNIDAFAEEHNVINVYSENKTLSGKIIEAMGIARGNILCFLDDDDMFYREKLEYVFKKFNENKNLCYLHNNFTAIDRDGKPLAYYNRNPDFNMSSISIRRETINGDAFGKVSKSIDTLIYLYAKESGMELELDSRELTYYRVTDQSVTHSFTDFNSFMEFSYNSLNIILNSYIQMLPLFHSRETRGIIKHKISFTRIRLNIFGGNVARLKDYLVLLYTPALESRSYEIKVAIASLFMRKYSAGKLYKNEKMKQEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4D6</accession>
    <name>A0A1V0N4D6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur cluster assembly SufBD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142475.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4D6"/>
    <dbReference type="STRING" id="74969.FAD_1087"/>
    <dbReference type="GeneID" id="31676585"/>
    <dbReference type="KEGG" id="fai:FAD_1087"/>
    <dbReference type="OrthoDB" id="300624at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055346">
        <property type="entry name" value="Fe-S_cluster_assembly_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508">
        <property type="entry name" value="FES CLUSTER ASSEMBLY PROTEIN SUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508:SF1">
        <property type="entry name" value="UPF0051 PROTEIN ABCI8, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="Stabilizer of iron transporter SufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD core" evidence="2">
        <location>
            <begin position="154"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="404" mass="46517" checksum="63DBAC6450544443" modified="2017-06-07" version="1">MIENYLETLNQRFRDFDIEYRKQAYIYYLKYPDPSYKESPDKKTYVNITEKDLERMAYGELSVSIKKDEKIDSNYDLVVTDSDFIISGKKKEVYISNMKTAFEEKKDLFKKYVDQQLGKYNREYLINFSYENGYFIHFPDNTTTDVKIESIQDSNASFAFKNVIIVGKNASVEITDVYKKHNKGNGVHGRNIYIFCEEGSHVKYNYVQDEGEDTVNLTYVRPVLYRDSEIRIIDVNAGANKVFYNHESEMYDNTTMKSYGVNVSRGDQEMDIWDSSVQYGKYSNCDINIKGVVLDRSSTMHRGNIDIEPEGVKSSGFYGSAILLMSENGKGNSKPALLIKNNDTKSKHSSSISSLDPEQIFYLRSRGLSEAEATDMIINGFTGYIEDITDNEFLKATIKDILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4J4</accession>
    <name>A0A1V0N4J4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="7">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartate transcarbamylase</fullName>
            <shortName evidence="7">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrB</name>
        <name evidence="11" type="ORF">FAD_1186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterooligomer of catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4J4"/>
    <dbReference type="STRING" id="74969.FAD_1186"/>
    <dbReference type="KEGG" id="fai:FAD_1186"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000001">
        <property type="entry name" value="Aspartate carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF6">
        <property type="entry name" value="ASPARTATE CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="10">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="9">
        <location>
            <begin position="156"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="308" mass="34215" checksum="183B1C3812A2E07E" modified="2017-06-07" version="1">MVIMLKNRSIISISDLDGEDINEVFSRADKMLENIESGKKINVMSSKILATLFYEPSTRTRLSFESAMERLGGSVISMADSKTSSTSKGETLADTIRIVESYSDLIVIRHPLEGAAFLASRFSSKPIINAGDGSGEHPTQTLIDLYTIRKEFGSIDGKTITIIGDLKYGRTVHSLLSALSRYNVTVNLVSPENLAIPKHVYNDVKGRLNMNISTDITKYLGETDILYVTRIQKERFTDKNEYARLIGSYKITVSDVNKLKKGAIIMHPLPRVDEISSEVDNTPAARYFKQAYYGVPVRMAIISMIAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4L0</accession>
    <name>A0A1V0N4L0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl-coenzyme A reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4L0"/>
    <dbReference type="STRING" id="74969.FAD_1189"/>
    <dbReference type="KEGG" id="fai:FAD_1189"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00644">
        <property type="entry name" value="HMG-CoA_reductase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="401" mass="43695" checksum="398BB18583CBA38B" modified="2017-06-07" version="1">MTVDERRQIIREFSGLSSEDMEAMDYRMDISTAGNMIENVYTIMDYPVGIATNFKINDKEYLIPMSLEEPSVIAACSNAARYARPGGFTAYSTNSYMRGEIELYNVPDPDYAAINILKNKENILKMANTRSKTLSGMNAGAKSIDLHFVNNELIINIIIDVADAMGANIINTMLEYVSGYIEELTGGQANLRIMSNLTTERITYAYAKFDGKMLGEETVDRIIRANEFAKNDIYRATTHNKGIMNGIDAVLLATMNDFRAQEANSHAYASMGGYGPLTEYRKDIDGNLIGSIKIPIAVGTVGGATKTSRKAMLAMKIMGIHGSNEFSNILGSVGLAQNFAALRALAAEGIQSGHMKLHARNIAIAAGATGEMVEKVAGEMISTGSISYTAAVDIIKKFRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4L4</accession>
    <name>A0A1V0N4L4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="6">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purC</name>
        <name evidence="8" type="ORF">FAD_1168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4L4"/>
    <dbReference type="STRING" id="74969.FAD_1168"/>
    <dbReference type="KEGG" id="fai:FAD_1168"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010564">
        <property type="entry name" value="PRK13959.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="296" mass="34611" checksum="59C6838C5884D0CF" modified="2017-06-07" version="1">MGMELLRKGKVKDVYDDGKDLVFKFSDRISVFDKIIPDSIPHKGESLCRTSTYWYNIVSSLGIDTDFIELVSDSEMKVKKFRQIDRGYKFLSNYMVPLEFITRYYLAGSAYDRVKSGEIDYHSLGFKNPPVYGEKLPDPFFEVSTKFEKFDRYLHTDEALEISGLDAGELCEIQETIFKIDRRINSSVESRGLIHADGKKEFALGLERKPVIIDTFGTLDEDRFWDKKDYENGQVNELSKEMVRQYYRKTGYHQKLYDARDNNQPEPDIEPLPENIVKTVSDLYIHMYEKITGLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4L9</accession>
    <name>A0A1V0N4L9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1171</name>
        <name evidence="3" type="ORF">HLB00_05385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000179">
        <property type="protein sequence ID" value="NOL60267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886274.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4L9"/>
    <dbReference type="GeneID" id="16024399"/>
    <dbReference type="KEGG" id="fai:FAD_1171"/>
    <dbReference type="OrthoDB" id="384888at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="227" mass="25290" checksum="855C194DC794A53B" modified="2017-06-07" version="1">MEYTFKDGKIYQDDNEIYTIKSNSSSLGAKSIEISNTSGLQSVYIDKAPGGYKISQGSMDMGTLSRNLVMSYNGRTYSLSKPYADMDTRKMDIKSDDSKIGTLTFGAGVLTGTYDYMNDEVPVIVYMSVMSPYVKSTYNGINAQNPQGNRRANAYRMPRIYAILSNVIFLVAIVIIVFSTSLGIPGDYDFLILIIVIALSFVIRSAGRKKYQEEHKNDEDNGMNKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4M5</accession>
    <name>A0A1V0N4M5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142565.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4M5"/>
    <dbReference type="STRING" id="74969.FAD_1187"/>
    <dbReference type="GeneID" id="31676685"/>
    <dbReference type="KEGG" id="fai:FAD_1187"/>
    <dbReference type="OrthoDB" id="145984at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="117" mass="13437" checksum="D5267224400C16F7" modified="2017-06-07" version="1">MEDLKDIVKKYYIAVDKNDLDTLFSIFADNIVYKRPGYEPIEGMANFKEFYQKNRIIKEGHHTLSNIIASDPYVIVEGEFNGILKDGSKSHTTFVDVYTFSSGKAIKRHTYFDGQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4R3</accession>
    <name>A0A1V0N4R3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142631.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4R3"/>
    <dbReference type="STRING" id="74969.FAD_1223"/>
    <dbReference type="GeneID" id="84217817"/>
    <dbReference type="KEGG" id="fai:FAD_1223"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="101" mass="10575" checksum="16BC7B472121FB48" modified="2017-06-07" version="1">MDVSGYIILAIALIDGLLFGLAIKKGIVSAILLIIAFVLASYAGLSFVPNVSFSKVYTYAKTFFIDNISKAPGLVSLGHVGSVTLVLVLFLIGLGVGIWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4U5</accession>
    <name>A0A1V0N4U5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="12">DHOD</shortName>
            <shortName evidence="12">DHODase</shortName>
            <shortName evidence="12">DHOdehase</shortName>
            <ecNumber evidence="12">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pyrD</name>
        <name evidence="14" type="ORF">FAD_1256</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-dihydroorotate + A = orotate + AH2</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-dihydroorotate + NAD(+) = orotate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="12">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer of 2 PyrK and 2 PyrD type B subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142682.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4U5"/>
    <dbReference type="STRING" id="74969.FAD_1256"/>
    <dbReference type="GeneID" id="84217851"/>
    <dbReference type="KEGG" id="fai:FAD_1256"/>
    <dbReference type="OrthoDB" id="36608at2157"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004589">
        <property type="term" value="F:dihydroorotate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049622">
        <property type="entry name" value="Dihydroorotate_DH_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005574">
        <property type="entry name" value="PRK07259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 12" id="KW-0288">FMN</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD85124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="298" mass="31037" checksum="773479FA5B00D356" modified="2017-06-07" version="1">MKLKPDIGIGAGNPFILASGILDANGYTIKRILENGAGAAVTKSIGSEERKGFDPPVIYSDGRSVINAIGLSNPGIENYGQEIKIATSSGKPVIGSIFGQTPEEFAMLAGKMQAYGASAVELNLSCPHVKGYGTEVGSDPELVSAIVSAVKSRINIPVYAKLSPNTSDMLEQAIAAGKADGYVLINTIKAMKIDINTGKAVLSNIYGGLSGKSIKPVGIRYVYEVKKETGKTIIGVGGINNFEDALEYIMAGASAVQIGSAISQAGIGIFANLTKELESYMEANSIDNIEELVGVAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4V4</accession>
    <name>A0A1V0N4V4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4V4"/>
    <dbReference type="STRING" id="74969.FAD_1269"/>
    <dbReference type="REBASE" id="196054">
        <property type="entry name" value="M.FacYORF1269P"/>
    </dbReference>
    <dbReference type="KEGG" id="fai:FAD_1269"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="entry name" value="Adenine-specific Methyltransferase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="DNA ADENINE METHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="253" mass="29221" checksum="7E17ADD73B4FAEC8" modified="2017-06-07" version="1">MKYPGSKTAIVGEIQRLFDISQCTRFVDVFSGSGSVIINIHAGIEVYNDLNRELFILFNSLKNNFSQLYRAADAVARDRKMFFDYYDGRIVMDTGNPEIEKAFSIFFNFNTGFGGMGNSYGKKDKSLFGTYRKNVSNLLKAESKIRKMKIENMDFREVIDKYNDPDTFFYLDPPYPGKDWYVHNFLESDFIELRNTLGSIKGKYLMNFNSTDKLPVKVFGKPSFVKEYENENGKPGETNARKVSFYTNMNVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Y8</accession>
    <name>A0A1V0N4Y8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1339</name>
        <name evidence="6" type="ORF">HLB00_03185</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000101">
        <property type="protein sequence ID" value="NOL59837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142818.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Y8"/>
    <dbReference type="STRING" id="74969.FAD_1339"/>
    <dbReference type="GeneID" id="84217951"/>
    <dbReference type="KEGG" id="fai:FAD_1339"/>
    <dbReference type="OrthoDB" id="43754at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="155" mass="17764" checksum="0CBD6D7CB633F74E" modified="2017-06-07" version="1">MAYMAAGNSFFGYPRGFEIKDSETIMEIIKCSLSEYYTKSLILDLYRAWPQAFIVYDNFDSVVGFIIGAKYSGTEGRILLFAVKQEFRYAGIGKALLTQELNVMIRAGLSTVRLEVRTDNENGIKFYKRNGFSIISTLKNYYSDLSDAYLMWKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Z7</accession>
    <name>A0A1V0N4Z7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dGTP triphosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795584.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Z7"/>
    <dbReference type="STRING" id="74969.FAD_1319"/>
    <dbReference type="GeneID" id="31676812"/>
    <dbReference type="KEGG" id="fai:FAD_1319"/>
    <dbReference type="OrthoDB" id="8895at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="377" mass="42938" checksum="18464F6D65B79ED1" modified="2017-06-07" version="1">MYKIIQDPVNGPVKIEGLFSEIVDSRYFQRLRYIKQLGLCNLVFPGANHTRFEHSVGAMFMAHELSESLGVKDEIPAIAALLHDIGHMPFSHGLENEFYGLYGKVHEDMTKDVILGKGPYGDSTIPDILEKYGYNPWEIAEVATGSSKKYPLFSTMVSGPIDVDEIDYLRRDALFCGVTMGQIDYKRLFNTLIVEGTDLVGVEKSIPTIESIIITRILMFNTVYFHKTCRIAQKMLGYAYLENNEKNSDDMKMTDYQFINKLEKGNSSELVRSIMNRNLFKVAYRGAYTEGAEKNINSLLQDFQEHEYIVDIIPPLYFAGSSRIKNYAKVYYRGKMENINNVSSMAMALSGEMENKQLIVSASEKSYDKIRKLLKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N524</accession>
    <name>A0A1V0N524_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2029 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142826.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N524"/>
    <dbReference type="STRING" id="74969.FAD_1344"/>
    <dbReference type="GeneID" id="31676836"/>
    <dbReference type="KEGG" id="fai:FAD_1344"/>
    <dbReference type="OrthoDB" id="42409at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="70084" checksum="EDDFC7CAA7022F60" modified="2017-06-07" version="1">MEKTGTLDRIQRIILNETATVLILSAFVAFGLFGYLNVYAIVLETALLLLAFIILLASNLNGWFRFKPFYVQAFLYSTMLLVDMVIFLAVSNRAMKYVLLAVATVLLLIVSYIFYKDPDSYAFLKKREHMVKPIYIIVSAAFIVAVSAIAVLVAFEPTDEFLIDLYSAMKFMHGLNPYNPATTAGVFLYFKHFNLDLNVTPTMYGKDITLQGYPALAFLIYIPYVYIGKFANLIISAIAFIPFIIIYKKFNNRKVALYAMFALLVNVIFLYSSAFSLIGLVWVVFIMVSYYYRDKPVYSGIFFGLALSAKQFPAIIFPFMFYMIYREKGIVAAIKWTLSAFLVFMLINGYFIIKSPVLYFKDILSSEIAKLIGIGFGPSQLSFLNFIHIPATMFTVLLVLSLVVTFILYVTHYDTLKFELFAFPMLILLFNYRLLITYVAFWPIISLISIEDINYKKKINIDKKALKRYATYAFAILIAILIVGAYFGVHSTEDVKVNSISLDMSKGKIQKIYMNVTYTGTASENIYFRGIINETNYNGLLFNYTGNRLSPGSTTNITLYPVRGETIPDNITIDLIGYNGTVQGSSAYTINNWKVTPYHDLLYNPPQNKLSLSQSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N529</accession>
    <name>A0A1V0N529_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative phage metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142846.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N529"/>
    <dbReference type="GeneID" id="31676847"/>
    <dbReference type="KEGG" id="fai:FAD_1355"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043998">
        <property type="entry name" value="Put_Metallopep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18894">
        <property type="entry name" value="PhageMetallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Putative phage metallopeptidase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="225" mass="25808" checksum="CDFA5CB121816F10" modified="2017-06-07" version="1">MIQLQRSKHGRKTDITQRFNAIIDYDLSKKYTALTKHITHIDLEIFKFPALNKMYRSPSFTPLGKQAKIFINENFFDALDDNEREALVFHEPYHFIRKDASKTYILALTILLIVAVSLIVLIQFWLSGFHFLFIISAIVALSSIVIVILILKLHLIYSEISADTFAAQTIGTNIPAISVVNKAYGIVIQHHRNNRKIYNAIYHGKKISLEKKTHLNIADESKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N544</accession>
    <name>A0A1V0N544_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA 3'-end processing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142856.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N544"/>
    <dbReference type="STRING" id="74969.FAD_1362"/>
    <dbReference type="GeneID" id="84217969"/>
    <dbReference type="KEGG" id="fai:FAD_1362"/>
    <dbReference type="OrthoDB" id="40950at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16295">
        <property type="entry name" value="TTHA0252-CPSF-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF52">
        <property type="entry name" value="MRNA 3-END PROCESSING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="3">
        <location>
            <begin position="224"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="409" mass="46315" checksum="D007713587DBB1F4" modified="2017-06-07" version="1">MKIKFLGGAEEVGRLAIKIEDKQSKIMIDYGIEPEKPPEYPLPPEKVNDIFLTHAHLDHTGALPVYYHNFQANFHATAMTANSIKPILMDSLKIMRLENYTKMFNEEDVDNLFKSMMTAKYEQPFQVDNLTAVAHSAGHIPGSTMWWFQDARSFMITGDLYTKDTNLLYGAKPVKTDVLIMESTYAGRDHEDRDEVIQRLKESIRETIENGGRVILPTFAIGRTQEMIMTLRDMDYRIYVDGMGNRISGIYMDTPGFLKDPKLFRRSMGRVIQVRNNRMRQEAIREADIIITTSGMLDGGPVLGYIDAFAEDPKSAIFLTGYQVDGTNGRSLIENGTIQIAGATIKPAMKIDFFDLSAHAGHSDLVKFVKGVDPEIVVLCHGDQREKLQESLPEYKFILPFNGHEFTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N558</accession>
    <name>A0A1V0N558_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142893.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N558"/>
    <dbReference type="STRING" id="74969.FAD_1419"/>
    <dbReference type="GeneID" id="31676912"/>
    <dbReference type="KEGG" id="fai:FAD_1419"/>
    <dbReference type="OrthoDB" id="34275at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000462">
        <property type="entry name" value="Glyoxylate reductase (NADP+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF283">
        <property type="entry name" value="GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="109"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="314" mass="35275" checksum="1ED37D995F582373" modified="2017-06-07" version="1">MYKVLVRHELLGNYLNTMKKDKNIELLFYNNNGSIRQWLIDNIENADGILITSNEKIDKEIINRAKKLKVISTYSVGYDHIDVEYAKSKGIVVTNTPEVLTDATADLIFGLMIAAARNIVSGNNLIHKNEWKAGWNPTFMLGSEIHGKTLGIIGMGRIGKAIAKRASGFDMKIIYYSRHRHDVNATFVDLDDLLSLSDYVVIALDLNNDTFHFVDYEKLSKMKKTAFLINGTRGKVVNENDLVKALNEKIIGGAALDVFENEPVDNKNPLLAFPNIVVTPHLGSATYETRDKMAYVAVKNLSNVINRKEPLYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N559</accession>
    <name>A0A1V0N559_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142868.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N559"/>
    <dbReference type="STRING" id="74969.FAD_1380"/>
    <dbReference type="GeneID" id="31676872"/>
    <dbReference type="KEGG" id="fai:FAD_1380"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="10"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="396" mass="43952" checksum="7DDA8A71EB950B4E" modified="2017-06-07" version="1">MQKPASTNKIVILSAFGMLLDGYQLTVIAFAVLLIPDYIHLSDYSLDYGLLIASVIIGAIIGTILVGYLSDLVGRRRVYLSTLLFFILFDMISVFSVNFYMLFISRVLLGVVLGAEYPVANSYIAEVTPSDKRGFYLAFATVFFSVGSISSAIVAVFMFPLGNIGWRLMLGVAVIPAIIVEFMRFSLPESKLWEEKKEKTGFLEMFSKKYSKNIILAALIWFLYDIVAYGLSLTLPTILKLGHFVTNVDNALLTTFFLVIGIISGVFVMIKVDKFGRKGIQITGFLMMAILFLILPHYYFLVGIIVIVSFLELFNSFDGATVGIIPAEVTITRFRGTSYGFSSMMGKIGAVIGVIAMSLLIHGKNYFNAYIFLAVIMIIAILLTLLLPETKNIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N561</accession>
    <name>A0A1V0N561_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886467.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N561"/>
    <dbReference type="STRING" id="74969.FAD_1367"/>
    <dbReference type="GeneID" id="16024592"/>
    <dbReference type="KEGG" id="fai:FAD_1367"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011470">
        <property type="entry name" value="PRK14887.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8798" checksum="2F40A8FD7145C988" modified="2017-06-07" version="1">MFRVKLTLKKSEYIKYLEAIRPEVTETFGRSSVAVKEDNSSIYIIITAPDTSSLRASVSSITRVLNVTKKIMEEDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N562</accession>
    <name>A0A1V0N562_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886514.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N562"/>
    <dbReference type="STRING" id="74969.FAD_1403"/>
    <dbReference type="GeneID" id="16024640"/>
    <dbReference type="GeneID" id="31676895"/>
    <dbReference type="KEGG" id="fai:FAD_1403"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="39"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="470" mass="51018" checksum="7088EB2F6D13E527" modified="2017-06-07" version="1">MDNLDSKSGLATHTLSMWQALAQGLGTNGPAAVTALFFVGIAGAVGSSMTLVIVLAFIIYCGMTLVTYEWSKEVASAYSWAAFHRKAFGDRGKFLSFYGGISYYYYYLLGYTGFAMLGLTAFLYALDPSLAAAYPWIWIPLTIIIIGETTVLNFFGVKLSLKYVLYTGLAEFIFLIGTSIALIVIAGPHNSYVPFTAAAVHFNYTDIAIEMILGIATFGGLNSVVPVAEETKNPKKNIPLALGILAGLIGAVIIISSYAQSVVYGVTNMFQYANLSDPGIYVYTKYLGLAVAAVFVLFIINSFNSSGVAFETSTVRTSYAYARDKILFPKVFTSINKHKVPGNLVIFTGLLSITIAIVSGLILGPLTASLFLIISNSIFSFSNHAIAGIGLGVYHRRKGTLRIIQHLIIPWAVAIALVVAIVYVVYPAPAPPLNYASYISGIYFVFIIVLYFYYRAKKPDMLEEVGKFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N576</accession>
    <name>A0A1V0N576_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate formimidoyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886496.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N576"/>
    <dbReference type="STRING" id="74969.FAD_1385"/>
    <dbReference type="GeneID" id="16024622"/>
    <dbReference type="GeneID" id="31676877"/>
    <dbReference type="KEGG" id="fai:FAD_1385"/>
    <dbReference type="OrthoDB" id="56032at2157"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030409">
        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="entry name" value="Formiminotransferase, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="entry name" value="Formiminotransferase, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013802">
        <property type="entry name" value="Formiminotransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004227">
        <property type="entry name" value="Formiminotransferase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051623">
        <property type="entry name" value="FTCD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02024">
        <property type="entry name" value="FtcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234">
        <property type="entry name" value="FORMIMINOTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234:SF8">
        <property type="entry name" value="FORMIMINOTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02971">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01221">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="Formiminotransferase domain of formiminotransferase-cyclodeaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formiminotransferase N-terminal subdomain" evidence="9">
        <location>
            <begin position="2"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Formiminotransferase C-terminal subdomain" evidence="8">
        <location>
            <begin position="181"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="298" mass="33352" checksum="E87376B244732F41" modified="2017-06-07" version="1">MKLVELIPNFSDGRNKVVIDLLEKDVKSVPDAKLLDSEMDYDHNRSVITVVCPIDNVIDLAFNMIKTAGENIDMNVQTGFHPRFGATDIMPLVPLEDTSMEECIELSQELGKKVGKELGIPVFMYAYSAKTPERKNLENIRNKKFQIEELRSAIGTGNYIPDYGPEVIGRAGATIIGARDFLIAYNIYLNTDDIKIGRKIASAIRARDGGFACVKSLAFKMPEKNIVQISMNIVNYRKNPVYRIFEAVKTEAKGFGVYPVRSEFIGMVPQEALVDSFNHYLMSGIKNKNVLDYAPGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N581</accession>
    <name>A0A1V0N581_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886506.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N581"/>
    <dbReference type="GeneID" id="16024632"/>
    <dbReference type="GeneID" id="31676886"/>
    <dbReference type="KEGG" id="fai:FAD_1394"/>
    <dbReference type="OrthoDB" id="134886at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295:SF8">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="228"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="51994" checksum="6DBC0110DC1BD651" modified="2017-06-07" version="1">MEGSKLAFRKVISEWLLASVPEAHKRNINVSMDSNKIITIIGPRRSGKTYFLYYLINELLKTEPKNNILYINFEDERLMNVTISDMDNIIPLFIELANPSKDKKIYLFFDEIQNIKFWEKYIRRVYDTSKYKIFISGSSSKLLSREISTSLRGRNIEYTIMPLSFQEYLEFNRMEYSNLAGYTDQRGYILSELNNYFKYGGYPEVALEKNDNNKLMILKSYYNTIFSMDMAEHFNISEVNVLDAFMKYSVSIYSKYFSISKIYNTFKSVGYKISKNKLLEFLYDSREIFFLFSLNIYTRSENKKMSYNKKIYSVDPGIIYALKNEMSITRLMKNIVFLELNHRCIENNLDVSYWKEYGKANGKEVDFVVSDSLKIVELIQVTYASDASEIDKREISALLSAAKYFEAHKLSIITWDFKGVIIENNEKIIFVPLWEWLLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N587</accession>
    <name>A0A1V0N587_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="5">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_1450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142913.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N587"/>
    <dbReference type="STRING" id="74969.FAD_1450"/>
    <dbReference type="GeneID" id="31676943"/>
    <dbReference type="KEGG" id="fai:FAD_1450"/>
    <dbReference type="OrthoDB" id="52866at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="HisA/PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF7">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD85308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="229" mass="25261" checksum="F2FA8CA7E46C4043" modified="2017-06-07" version="1">MIDIYPAIDIYNGEAVSLENGKIEKIESFGDPVKFAQKFSSISGKLHIVDLNGAFTGNPANTNLIKSIRKNVKSFIQAGGGYRTMESIETGYSLGIDSIIIGTASLDKKILEEVSEKYKNITISIDAYNGYIKYNGWADGAGISYRDFYSMVKGMANRFIFTAINSDGTGHISRIEKFWDEGYFMYAGGVNSIDDLKKLESMGFNGAIIGKALYNGNIKIEELKCLQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N588</accession>
    <name>A0A1V0N588_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N588"/>
    <dbReference type="KEGG" id="fai:FAD_1418"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="69" mass="8341" checksum="400DA8B11963ADC2" modified="2017-06-07" version="1">MGKIDYIIRDKNSPYVITAVLKRDILSCYLMIKLIDNRRFIFTQNFVHNLFAWRNTSIYLMKALYRSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5F4</accession>
    <name>A0A1V0N5F4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-ketoacyl-(Acyl-carrier-protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886650.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5F4"/>
    <dbReference type="STRING" id="74969.FAD_1511"/>
    <dbReference type="GeneID" id="16024777"/>
    <dbReference type="KEGG" id="fai:FAD_1511"/>
    <dbReference type="OrthoDB" id="24596at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005056">
        <property type="entry name" value="PRK06463.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="255" mass="27887" checksum="071FD8523FE5E563" modified="2017-06-07" version="1">MGKLDNKIVLITGSSRGLGKAIAMKFASEGARIAINYNRDQKSAMELKNMLAGSEIFQADVSDHAAVRNMVNEIHRKMGTIDILVNNAGILSAITWDEFDDARVKKIFDVNLMGPVYTTRECIEDLKKQHGIIINLASNAGVGTAAKGTTFYSMTKAAITMLTKRLAFDLMDWHVRVNAIAPGWIESDMTIGGKSEEEVNNLRQSFKSKTELGMTGKPENIADAAIFLASNESEYMDGQVLVVDGGRIDNLTHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5G6</accession>
    <name>A0A1V0N5G6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate dehydrogenase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886576.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5G6"/>
    <dbReference type="STRING" id="74969.FAD_1471"/>
    <dbReference type="GeneID" id="16024701"/>
    <dbReference type="GeneID" id="31676964"/>
    <dbReference type="KEGG" id="fai:FAD_1471"/>
    <dbReference type="OrthoDB" id="23466at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.90">
        <property type="entry name" value="ADC-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.228.10">
        <property type="entry name" value="Dimethylsulfoxide Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF10">
        <property type="entry name" value="NADH-QUINONE OXIDOREDUCTASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="650" mass="71968" checksum="94E31474605D2A68" modified="2017-06-07" version="1">MKSICPFCGVGCGLELMAVNNIVVGVKPVPEHVVSRGHLCGKGSVAHEALTAWDRLYYPLKKVKGELERTSWEDSIKYTIESIKNIQKKYGKDSVAFYGGCQNSLEEVYLLQKLARALGTNNVDSCARVCHDPSAKALKEIVGVGAGSNSATEIPKAKVVVVAGESVTDSHPVLIQYFLEAKEKGTKIILIDPRNTRFASFADLHLKIKPRSDIFLFNAVANYLIQNNMIKPDFIAARTEGYEKYKENVSKYTLELAVEQTGLAEKDIIEFAKYISEDKVIFSWGLGLTESTGTKGIKSYLSLPLLTGNMGKEGAGVIVYRGQTNVQGSGDLIKPDVFPNGEMNEANSEALSRIWGFKPPVNKGSSIIDTFYGSKNIKALFIMGYNPVRSLPNRKKVKEFLGSLELLVVQDIFMTDTARYADIVLPAAAWAEKEGSVASLDRLVKWRFKAVDPPGMARPDYEILSDLAKAAGYNFNSNPKELFEELKTAAPLYSHLNIDDVMDYSKDSRYPNGELHLYGEKFSTKSGKAQFIPVDSEKHNDGLILVTGRTVTRYNSDEVINRVPGMQEYNPTLWVNPSDAKNLGIENEDMVKLASKSGELDIIAKITDDVIPGVVFTYMHNPKINDIVSPEFDDETKTPKYKYTPVTVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5H1</accession>
    <name>A0A1V0N5H1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN-domain RNase, VapC-type toxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Type II toxin-antitoxin system VapC family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1487</name>
        <name evidence="3" type="ORF">HLB00_06965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000251">
        <property type="protein sequence ID" value="NOL60568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886595.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5H1"/>
    <dbReference type="GeneID" id="16024720"/>
    <dbReference type="KEGG" id="fai:FAD_1487"/>
    <dbReference type="OrthoDB" id="168412at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051619">
        <property type="entry name" value="TypeII_TA_RNase_PINc/VapC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901:SF1">
        <property type="entry name" value="EXONUCLEASE VAPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901">
        <property type="entry name" value="RIBONUCLEASE VAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="127" mass="14286" checksum="3093794C886B0F29" modified="2017-06-07" version="1">MNILDTSSIFNLFQRGKYTEIMDNATIPLAVYEVGNVIWKNSNIKNTITQEEAKDIGSVLFELINSIEQVIPTWSSVLSLALKEGLTFYDSSFLVSAIEKGYGLITDDIKLFRVASSRITVRMSRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5I6</accession>
    <name>A0A1V0N5I6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NADH-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1527</name>
        <name evidence="3" type="ORF">HLB00_02620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000082">
        <property type="protein sequence ID" value="NOL59727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886664.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5I6"/>
    <dbReference type="STRING" id="74969.FAD_1527"/>
    <dbReference type="GeneID" id="16024793"/>
    <dbReference type="KEGG" id="fai:FAD_1527"/>
    <dbReference type="OrthoDB" id="213145at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="280" mass="31666" checksum="7D903581A9C72F90" modified="2017-06-07" version="1">MKLIVLGGSGFVGSNILKQMDAEEKAYFSRNNSDELDKLGIKYIKGDVREYDDVKSAIADYDVIVHAIDVLAETEETHEDLSLKGVKNVVNAMQELRGNKKLVYFSAINADKGSTDYFRYKRLGEDNANLLKNSLIIRPSTMFGPGDKFTKMLIEVAKGKVPMLPKSGNMAPVHINDVITVIKNSMERSGTIDICSRERVTFADMFNIVRAKLGMPPVKEISSIVFKPFVGSLQKRGLLTKEQFYMLQLDYYKENTSLFRYVKEPITFKDYINSTDINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5J4</accession>
    <name>A0A1V0N5J4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5J4"/>
    <dbReference type="STRING" id="74969.FAD_1504"/>
    <dbReference type="KEGG" id="fai:FAD_1504"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23518">
        <property type="entry name" value="C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23518:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="403" mass="44854" checksum="8CF7E28AC583F9B3" modified="2017-06-07" version="1">MFIVFYLKSNVEFVGLVSAISSLASVPALIVWGNLSDKIKRRKIFIIIGFVGSFLSLLLVLVVHTVSTYMSMLILFQIVAMASVPVSTLLILENSDKSSWSNVMGKFNSYSAIGTVLGLGIGVLILTFFSGMGRELIPYLYIVAAWFYLIAGIISILVLKEPKTEISRGKIGYLYALHAIERVRYFPTHLVHIPGKENKIKIPDYLKLYLITTLILMMGFQLFFIPYPVFVIDRMNASENDIYIMYLLNSLFSAATFIPAGRYINYIGSNRMLSISTSIRVVLFLVMGVVSFFVFDTVGYLLLFIVMYGVFGAIWSFIGISEITSISNMATTLIRGKVIGYYNSLNGVGQIIGAGLSGFIAYDIGYSFDFILSAIIVLSGLLIIFYSKPPDIQYSKKIIKSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5K2</accession>
    <name>A0A1V0N5K2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1535</name>
        <name evidence="2" type="ORF">HLB00_03600</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000114">
        <property type="protein sequence ID" value="NOL59918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886671.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5K2"/>
    <dbReference type="STRING" id="74969.FAD_1535"/>
    <dbReference type="GeneID" id="16024801"/>
    <dbReference type="KEGG" id="fai:FAD_1535"/>
    <dbReference type="OrthoDB" id="216309at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="entry name" value="DsrEFH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DsrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="DsrEFH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="115" mass="12422" checksum="7C3DF3EF8AF18447" modified="2017-06-07" version="1">MAKIFVILTKGKDDLNMVNVAANFSYNAVKNAGATVNFMFLGRGVENLLKDSNGIKPIIDLVDKMKSENIEVTYCKVSTKGLGLSEEQMLGGIEPVMGGVQTAKKIDEGFSVITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5N2</accession>
    <name>A0A1V0N5N2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5N2"/>
    <dbReference type="STRING" id="74969.FAD_1616"/>
    <dbReference type="KEGG" id="fai:FAD_1616"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="59" mass="6836" checksum="B2142583609CAA65" modified="2017-06-07" version="1">MGFYSILWIIIKYLLPIGILAYSIIKFNPFLIMISVLWLLVTLVVSLINFSIKSNFVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Q4</accession>
    <name>A0A1V0N5Q4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1569</name>
        <name evidence="2" type="ORF">HLB00_01025</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951147.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Q4"/>
    <dbReference type="STRING" id="74969.FAD_1569"/>
    <dbReference type="GeneID" id="84218163"/>
    <dbReference type="KEGG" id="fai:FAD_1569"/>
    <dbReference type="OrthoDB" id="384256at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="117" mass="13365" checksum="8436966BDE789A1D" modified="2017-06-07" version="1">MTANNDTSQVSREKEGRKVESGYAFKGGDISMDRFSEIEAIGEKIGNIWQDNDLSILDLKTLMPYLASMVFLEAGDSDFDILDYIDNYMKPAIFEFNRRLRNSRKFKSFDNNTAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5T6</accession>
    <name>A0A1V0N5T6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl11</name>
        <name evidence="8" type="ORF">FAD_1620</name>
        <name evidence="9" type="ORF">HLB00_01680</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000043">
        <property type="protein sequence ID" value="NOL59545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886751.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5T6"/>
    <dbReference type="STRING" id="74969.FAD_1620"/>
    <dbReference type="GeneID" id="16024885"/>
    <dbReference type="KEGG" id="fai:FAD_1620"/>
    <dbReference type="OrthoDB" id="8842at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002232">
        <property type="entry name" value="PRK01143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="158" mass="16359" checksum="B4A7AD83ACF30468" modified="2017-06-07" version="1">MVAVKTMVEGGKATSGPPLGPALGPLGLNLGQVIKDINEQTKDFAGMQVPVTVNVVDPSTKKYEIIIGIPPTSALLKKEAGIAKGSGKNKENYAGNLTMEQVKKVAESKKSGLLSYTMKGAVLEVLGTALSLGITVDGINAAELQKKIKAGEIDVGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5T8</accession>
    <name>A0A1V0N5T8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1-alpha</fullName>
            <shortName evidence="10">EF-1-alpha</shortName>
            <ecNumber evidence="10">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Elongation factor Tu</fullName>
            <shortName evidence="10">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tuf</name>
        <name evidence="12" type="ORF">FAD_1649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886784.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5T8"/>
    <dbReference type="STRING" id="74969.FAD_1649"/>
    <dbReference type="GeneID" id="16024918"/>
    <dbReference type="GeneID" id="84218242"/>
    <dbReference type="KEGG" id="fai:FAD_1649"/>
    <dbReference type="OrthoDB" id="371718at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="426" mass="47029" checksum="CF6E80745D3609AA" modified="2017-06-07" version="1">MAELPHMNLVIIGHVDHGKSTFVGRLLFEHGEIPQHIIDEYKKESEEKGKATFEFAWVMDRFKEERERGVTIDLTHRKFQTDKYYFTIIDAPGHRDFVKNMITGTSQADAAVLVVSAREGDGVMAQTREHAFLARTLGVSQLIVAVNKMDATQPAYSEKRYNEVKEQVTKLLTPIGFKDVPIIPMSGYKGDNIMKNSANLSWWKGPTIMEALNNLKVPAKPTDKPLRIPVEDVYSITGIGTVPVGRVETGVIKINDKVIFLPANKSGEVKSIEEHHTAMQSAEPGDNIGFNVRGIAKNDLKRGDVCGPVSAPPTVVKSFTAQIVVLQHPSVIAAGYKPVFHVHTAQIACRFEEIIKTINPKDGTTLKEKPDFIKAGDIAVVKVIPDKPLVIEKVSEFPQLGRFAIRDMGMTVAAGQCIDLEKATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5W2</accession>
    <name>A0A1V0N5W2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5W2"/>
    <dbReference type="STRING" id="74969.FAD_1700"/>
    <dbReference type="KEGG" id="fai:FAD_1700"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="74" mass="8003" checksum="76A4D32C59815C6C" modified="2017-06-07" version="1">MTAGTFLFFVSLIVLAIGAIFHSNGTILADSFLYGGLAFLISIILLAIGLVIGARSGKLQQRTDEIFSKKKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5W6</accession>
    <name>A0A1V0N5W6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143021.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5W6"/>
    <dbReference type="STRING" id="74969.FAD_1679"/>
    <dbReference type="GeneID" id="31677171"/>
    <dbReference type="KEGG" id="fai:FAD_1679"/>
    <dbReference type="OrthoDB" id="166758at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="330" mass="37064" checksum="44592BC67D6CAA9E" modified="2017-06-07" version="1">MSLKSDFTIDVIDTHTEGEPTRIMFWNNIPKNLRDALSVRKYFIDHYDYIRKILLLEPRGHKDQFGAILLPPVNPDSDYTVIYPTTESYLDMCGHATIGVSTALVALGYVPFEGNEKTLVYDTVAGTVKARVKIENGEPVSVSIVDVKSYFVKQIKVNVNGKDVDVNISYGGNFYAIVNSKDLGVDVEPEYIDDLLAYGKIIREKAYETLKELYPENRKNLEPLAMITDNNHDYRAIVTFAGNSFDRSPCGTGTAARAAFLVHEGKLKLDGSYVNESILRTKFECRIISWEKVNDTIAIVPEITGRAWVTQLCKLIVDPSDPLKHGFLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Y9</accession>
    <name>A0A1V0N5Y9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein eS27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps27e</name>
        <name evidence="6" type="ORF">FAD_1655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142999.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Y9"/>
    <dbReference type="STRING" id="74969.FAD_1655"/>
    <dbReference type="GeneID" id="84218248"/>
    <dbReference type="KEGG" id="fai:FAD_1655"/>
    <dbReference type="OrthoDB" id="5718at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001629">
        <property type="entry name" value="PRK00415.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="66" mass="7109" checksum="472B6E694556782E" modified="2017-06-07" version="1">MADEFKKLKDVGNNFLKIKCKDCGNEQIIYSKVSSVVVCNICGSTIAKPTGSTLATSGELVEKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Z6</accession>
    <name>A0A1V0N5Z6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="4">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1712</name>
        <name evidence="4" type="ORF">HLB00_00105</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000005">
        <property type="protein sequence ID" value="NOL59241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143046.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Z6"/>
    <dbReference type="STRING" id="74969.FAD_1712"/>
    <dbReference type="GeneID" id="84218332"/>
    <dbReference type="KEGG" id="fai:FAD_1712"/>
    <dbReference type="OrthoDB" id="27846at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004725">
        <property type="entry name" value="PRK06072.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43459:SF1">
        <property type="entry name" value="EG:BACN32G11.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43459">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="254" mass="27646" checksum="137B980EF6384B3A" modified="2017-06-07" version="1">MYNTLLIEDRGYVSVIEINRANKLNALGDDVRSDLLAAFKDFNSDPAKRIAILTGKGKAFSAGADLTSTSDKEVDIKDELSNSFHPILKEMVNSRKIFISAINGVAAGAGMSLALACDISFASRETNFIMGFHGIALAPDTGLVLILSRLAGAKARPYLLYGGSFSAKEAEEMGLVQVVDDPFMDAIELAEKLSNGPYRAYSVSKQLINQSLYYGLDEFLQDEARLQSDLGTSHDFREGVSAFREKRGPKFIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Z9</accession>
    <name>A0A1V0N5Z9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Z9"/>
    <dbReference type="STRING" id="74969.FAD_1665"/>
    <dbReference type="KEGG" id="fai:FAD_1665"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="195" mass="21588" checksum="37D0FF6287380B7D" modified="2017-06-07" version="1">MYIKRMVAGVLMVVIFTMILFAPAISSGYMGSNQVQLPDSPIICTQHSNLIIETKNVSSGLFSSVNSIDTGYFNVTQTYYYNYHDLEHDIACNVLGKVTGNTGGCTIITQQFSYVITASNSTGTFKEYNGYVVMKNLGFSWGGSYTHNYVAMNVNLEIYSNGDVFMQYSIAYSRTPSEISMAFIDITGLVKNMDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N603</accession>
    <name>A0A1V0N603_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN-domain RNase, VapC-type toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143030.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N603"/>
    <dbReference type="STRING" id="74969.FAD_1693"/>
    <dbReference type="GeneID" id="31677185"/>
    <dbReference type="KEGG" id="fai:FAD_1693"/>
    <dbReference type="OrthoDB" id="90145at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39664">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39664:SF2">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN, CONTAINING PIN DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="135" mass="15424" checksum="6E4DE90E7C94B995" modified="2017-06-07" version="1">MTLVVDTNVLVYDAIENSPQHGRATEIINESENIIINSLSIIEIGFVLPRYGINNNSVGMKLEELLHSDYFMVSWLSERMLEGTSTFIVENNFSFRDFNDWIIAYDALSRNAPLVTFDKKLSKQCKKIGIEIIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N631</accession>
    <name>A0A1V0N631_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic phosphate:H+ symporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886880.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N631"/>
    <dbReference type="STRING" id="74969.FAD_1738"/>
    <dbReference type="GeneID" id="16025013"/>
    <dbReference type="GeneID" id="31677229"/>
    <dbReference type="KEGG" id="fai:FAD_1738"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="27"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="471" mass="51217" checksum="6A8FA69C5EB349E8" modified="2017-06-07" version="1">MDNKNEGNISAINQALDNATGKFHFRTFLTAGMGFFTDAYDLFIIGTVLAILPMIGWHLTKTEIALIGSVSLIAAVLGALAFGRLLDYLGRKAIYGLELVLLVIGALGSAFLSFKNPYALMAWRFLLGVGIGGDYATSSVIMAEYSNMKTRGKYVGMVFSMQSIGLVVSSLLALTFLLSTKIIPLADAWKIMLSVGAIPAAIVIYYRRKMPEPPRYTVAKGRAAEASKNLKSYTGIDVAVSKNKEEVNAPWYTLFKDRKFLITLIGTAGAWFLMDWAFYGNSIMASRIFATIITQTGLSGLIRSTEYSAIVFIGFALPGYWLATFTLDKLGRKPIQITGFIMLAVTYGILALFPILDTPSFVVEFIAVYGISYFFMMFGPNVTTFVFPSEVFPVTTRGFGTGISAAGGKTGAFIGTFVDVFIIAAGLSSLMTVLAIFSVLGVIVTILCLPEPKGRAMEEISREKEYTKTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N658</accession>
    <name>A0A1V0N658_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing] subunit B</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GMP synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">guaA</name>
        <name evidence="15" type="ORF">FAD_1773</name>
        <name evidence="16" type="ORF">HLB00_01210</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Berkeley</strain>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000034">
        <property type="protein sequence ID" value="NOL59456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143081.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N658"/>
    <dbReference type="STRING" id="74969.FAD_1773"/>
    <dbReference type="GeneID" id="84218396"/>
    <dbReference type="KEGG" id="fai:FAD_1773"/>
    <dbReference type="OrthoDB" id="33844at2157"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="27"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="NOL59456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="306" mass="34298" checksum="124DC63F5FD6B987" modified="2017-06-07" version="1">MDAKKFIEESRELILSKLHGKGILACSGGQDSTLLSLIAAPIKNIEIIFVDTGLLRLNEVARVKSLFEKFGVKYKLIDAKKIFLDNLKGVVDPETKRKIIGKTFIDVFKKEAETFGATYLLQGTIAPDWIESGGASRDTIKSHHNVGGLPADLGFELIEPLRDLYKDEVREVSRYFGLPDVMPFPGPGLAIRIIGEVTEHKLEILKQATDILERSVNERYSGEKPWQYFCVLLSVKTTGVHGDQRTYGETIAIRMIDTLDGMTGTFSRPDWELISDISVNITDEVPEINRVVYDITDKPPATIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N668</accession>
    <name>A0A1V0N668_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N668"/>
    <dbReference type="STRING" id="74969.FAD_1737"/>
    <dbReference type="KEGG" id="fai:FAD_1737"/>
    <dbReference type="OrthoDB" id="17861at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051258">
        <property type="entry name" value="Diverse_Substrate_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920:SF5">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920">
        <property type="entry name" value="OS03G0707200 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="146"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="295" mass="32933" checksum="6CFE21FCBDF574F1" modified="2017-06-07" version="1">MQGKVLYFMLLISVVVIWGATFPIMKLSLQYISPVMLLSFRFILSAALMLPIVFKNKMLIERKNVILGIVGGILLFLAYYTQTVGLEYTTSSQSGLITGMYVVLLPIISLLYLKIKLNKVDVIAVSIGFIGLILMSSLKFSSAYTFGDILTFFCAIFYGLQTAYVFKYTKYLDSMVFTFYQLLMVGVLSSIFVPFSWEPSGLLKPIVIFTIVFTALFASFFAILINTRVLQYIEPTAAGVIYVGEPVFAVISSILILKEIPTMDIILGGIIIVVAMLIETLHKYVETKNSINIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6A4</accession>
    <name>A0A1V0N6A4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">A-type ATP synthase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ntpE</name>
        <name evidence="1" type="ORF">FAD_1824</name>
        <name evidence="2" type="ORF">HLB00_01760</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000045">
        <property type="protein sequence ID" value="NOL59561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886974.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6A4"/>
    <dbReference type="STRING" id="74969.FAD_1824"/>
    <dbReference type="GeneID" id="16025104"/>
    <dbReference type="KEGG" id="fai:FAD_1824"/>
    <dbReference type="OrthoDB" id="57284at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="189" mass="21894" checksum="F3B24D8DA51C62BA" modified="2017-06-07" version="1">MSLENILNEIDNTTQAELKAIRDEYSAKIEAIIKSCNDKISRIKNYYAVKSDNDVKNIIKQYEDNIRLQSKKIIDDKKKEILVNTMQKLRSYVTSLNKSSNYPELLKAMVNESKKELGNKFTVYCDEMENEKLQGFKFPDSIKFIIDKSIKSGIIAVSADGKKEVDMRLSSIFDEISYDVETYLYENIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6A8</accession>
    <name>A0A1V0N6A8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A-type ATP synthase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntpC</name>
        <name evidence="4" type="ORF">FAD_1823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143109.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6A8"/>
    <dbReference type="STRING" id="74969.FAD_1823"/>
    <dbReference type="GeneID" id="31677313"/>
    <dbReference type="KEGG" id="fai:FAD_1823"/>
    <dbReference type="OrthoDB" id="4272at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050873">
        <property type="entry name" value="V-ATPase_V0D/AC39_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38682">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38682:SF1">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="353" mass="40984" checksum="91D1810B1861E13C" modified="2017-06-07" version="1">MVVPINTTYSGSYGRLKIHFNDYLSDSFVKSLLELDIKDIRLKLYETSYRDDIDKATTISNDDVDILITAINRHVINNAKIALFAVPPQIKSFMKSYVSKWDIESIKAIITSKVIHHDIKYNDSFIMSFRDIPMGIYAGNLKRDDFRAIMEKNDVDSVINYLLNYGFNYLLKELEEYKKTGDTSSLLSAMDYRYYNDLIKTALFYNGDEGQIIKYVKTVVDLKNILTLAKAIELNVPFEKIENSIIDNGNFSRTALSDTFRSGSVIELLSLFKHFNIDEALDYYKENKNLSQFEIGMRKSLFHEFVPVMIRDTASLFIFAYILYAERERDNLRTIIIGKSYKLDNNTIERMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6B6</accession>
    <name>A0A1V0N6B6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-isopropylmalate dehydratase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6B6"/>
    <dbReference type="STRING" id="74969.FAD_1790"/>
    <dbReference type="KEGG" id="fai:FAD_1790"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050075">
        <property type="entry name" value="LeuD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345:SF2">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="3">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="175" mass="18895" checksum="2AFEC42495DA55F9" modified="2017-06-07" version="1">MGIFRVVSMNKIEGKAWIFGDDINTDLMYPQICYTLPEKEKPHHAMEANRPGWASSVRNGDIIIAGKNFGTGSSRPAADNIKNLGISCVLAESLNGLFLRNSVNSGLPSLEVHGISGIVKEGNIVAIDFSSNTVMDKETGKVMKFKPLPAFLMEIIDNGGIINILKNKGLLGPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6B8</accession>
    <name>A0A1V0N6B8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division cycle protein 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cdc48</name>
        <name evidence="8" type="ORF">FAD_1805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143101.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6B8"/>
    <dbReference type="STRING" id="74969.FAD_1805"/>
    <dbReference type="GeneID" id="31677295"/>
    <dbReference type="KEGG" id="fai:FAD_1805"/>
    <dbReference type="OrthoDB" id="77269at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19529">
        <property type="entry name" value="RecA-like_VCP_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000007">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000057">
        <property type="entry name" value="AAA family ATPase, CDC48 subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000038">
        <property type="entry name" value="spermatogenesis-associated protein 5-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="223"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="500"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="744" mass="82442" checksum="B98E7EEE29891B99" modified="2017-06-07" version="1">MKPNDGILLRIAEANATDPGMARVRLDEISRLDLDVEIGDVVAIEKVRSTVGRVFRSRPEDENKGIVRIDSVMRNNCGASIGDKVKVKKVEVEEAKKVVLAPIIRKDQKLRFGEGIDDFVQKALIRRPLIEQDSISVPGLTLAGHTGLLFKVIKTIPSKIPVEVSEETRVEIREDPASEVLEEVTKVSYEDIGGLSDQLGKIREIIELPLKHPELFERLGITPPKGVLLNGPPGTGKTLIAKAVANESGANFFAINGPEIMSKYYGQSEQKLREIFQKADESEPSIIFIDEIDSIAPKREDVQGEVERRVVAQLLTLMDGLKDRGHVIVIGATNRLDAVDPALRRPGRFDREIVIGVPDKKGRMEILTIHTRGMPLGMDDEKESEFFSRIADITYGFVGADLAALTRESAMNALRRYLPEIDLDKPIPTEVLEKMIVTEDDFMEALKTIEPSSLREVTVEVPNIKWNDIGGLEALKSELREAVELPLLNPDVFSRLGIRAPKGFLLYGPPGTGKTLLAKAVANESNANFISVKGPEVLSKWVGDSEKAVREIFKKAKQVSPAIIFMDEIDSIAPRRGTSMDSGVTERIVNQLLTSMDGIEVLKGVVVIAATNRPDIIDPALLRAGRFDKIIYIPPPEEEGRLKILEVHTRKMPLAKDVDLKDIARKTDGYVGADLENLCREAGMMAYRNNPEATEVNQDAFIKAMKTIRPSIDKNVTKFYNDLAATMGRDISEKKKTEDLGLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6B9</accession>
    <name>A0A1V0N6B9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional regulator GfcR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gfcR</name>
        <name evidence="6" type="ORF">FAD_1863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">Contains an N-terminal DNA-binding winged helix-turn-helix domain and a C-terminal regulatory domain (or effector binding domain) resembling phosphoribosyltransferase (PRT) domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. GfcR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143127.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6B9"/>
    <dbReference type="STRING" id="74969.FAD_1863"/>
    <dbReference type="GeneID" id="31677353"/>
    <dbReference type="KEGG" id="fai:FAD_1863"/>
    <dbReference type="OrthoDB" id="68893at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006222">
        <property type="term" value="P:UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01214">
        <property type="entry name" value="GfcR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022854">
        <property type="entry name" value="GfcR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002620">
        <property type="entry name" value="PRK02277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF41">
        <property type="entry name" value="PYRE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="193" mass="21249" checksum="6A8861BCA5CF8DCF" modified="2017-06-07" version="1">MKSLEELYNRALELKNKGMSDKEISTELHLSVNTITWLLSKDLKGNSVSDTKIGWRSVGVYGNRIEKIAEVMADIVTEEISLDNVTSIIGITINGIPYATMLSDLLDRELIVYRPHPSGKEGMFSSNFAGVKGKKIVIIDDVISTGETMKRTIEDVHNQGGEVVLCVVLVSKLNSDEINNVPVRSLIRATMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6F0</accession>
    <name>A0A1V0N6F0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asymmetrical bis(5'-nucleosyl)-tetraphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143126.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6F0"/>
    <dbReference type="STRING" id="74969.FAD_1862"/>
    <dbReference type="GeneID" id="31677352"/>
    <dbReference type="KEGG" id="fai:FAD_1862"/>
    <dbReference type="OrthoDB" id="26806at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="141" mass="16310" checksum="AF27C4313BA93084" modified="2017-06-07" version="1">MYDETCIFCREIANKGNAAFVYRGVNILAFMDNAPIEEGHVLVIPRNHYENIYDIDKDIYLELQLAVKRISIAVKNVLKTDGLNIGQNNGRVANQVVMHYHVHIIPRYYRKKINWERENANIDDLEIIAAKIRAGIKEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6F5</accession>
    <name>A0A1V0N6F5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">valS</name>
        <name evidence="12" type="ORF">FAD_1848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143121.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6F5"/>
    <dbReference type="STRING" id="74969.FAD_1848"/>
    <dbReference type="GeneID" id="31677338"/>
    <dbReference type="KEGG" id="fai:FAD_1848"/>
    <dbReference type="OrthoDB" id="23906at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02005">
        <property type="entry name" value="Val_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022874">
        <property type="entry name" value="Valine-tRNA_ligase_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009687">
        <property type="entry name" value="PRK13208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF93">
        <property type="entry name" value="VALINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="11"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="590"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="511"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="772" mass="89856" checksum="289B959CDEDF797B" modified="2017-06-07" version="1">MIDTVAIEKKWKDYWFNNNIFAFKKGDKNYTIDTPPPTVSGKMHVGHAFSYPQQDFIARYKRMKGYNVFYPWGFDDNGLPTEKFVEKERRVTIDNTPLKDYIEICREVSRESEKGLYQAWYDTGISADFKNYIDTSSDFSIKISQEMFLDLVAKKRAYRDEAPYITCPTCRTAISQIEMKDAIISTELVYINFNGIEIATTRPEMLGACVAIFVNPDDERFKKFIGTTVNVPVYGYPVKVMSDPSIDMEFGTGAEMLCTFGDQHDLELWKKYGIKARIILKNNRINDGSVIINMPIKDARKKIIDELQSKNYIIKIEKIKHSVNTHERCGTPIEIGISKQWYIKDLDIKNELIEFGNKIEWVPGHMKIRYDNWVTGLKWDWCISRQRYFGVPFPVWYCDNCGEIILAGNEELPVDPRLDNKKRKCEKCGSDNIVPETDVMDTWATSSLSPTLYLKHINQMDLYPMDSRFQGHDIITSWAFTTILRSYLHYGEIPWRKIVISGNVYDPFGQKMSKSKGNIVEPRAIIENYGADALRYWASTTMQGENIKLREQDLMRGRKTVIKLENSLKLIMMLANNKKPGNTIPEFPVNRWITTKMERTIKEVTEYMENNEIMKARISLDKFFWNEYCDNYLEMIKNESSKDDRRDETLSTAFSVFENILKMYSPIMPFITEELFHQANPSFSGSIGLEPYPEFDGQMIYNEENEVDYIIGVIDKIRNLKSQMKLSMAAPLDILKLHGDAKIIQKYDYILEGMMHINSMEIINSEDTYIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-02-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>E5KBS0</accession>
    <name>E5KBS0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DtxR-like repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Iron-dependent repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Metal-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1229</name>
        <name evidence="9" type="ORF">HLB00_07040</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Proteomics" volume="11" first="52" last="63">
            <title>Iron homeostasis and responses to iron limitation in extreme acidophiles from the Ferroplasma genus.</title>
            <authorList>
                <person name="Potrykus J."/>
                <person name="Jonna V.R."/>
                <person name="Dopson M."/>
            </authorList>
            <dbReference type="PubMed" id="21182194"/>
            <dbReference type="DOI" id="10.1002/pmic.201000193"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="HM998292">
        <property type="protein sequence ID" value="ADR78323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000254">
        <property type="protein sequence ID" value="NOL60582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142639.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E5KBS0"/>
    <dbReference type="STRING" id="74969.FAD_1229"/>
    <dbReference type="GeneID" id="31676727"/>
    <dbReference type="KEGG" id="fai:FAD_1229"/>
    <dbReference type="OrthoDB" id="24735at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050536">
        <property type="entry name" value="DtxR_MntR_Metal-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33238">
        <property type="entry name" value="IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33238:SF7">
        <property type="entry name" value="IRON-DEPENDENT TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="Iron-dependent repressor protein, dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Iron dependent repressor metal binding and dimerisation" evidence="6">
        <location>
            <begin position="63"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADR78323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL60582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="207" mass="23746" checksum="48FB03DC93FCD794" modified="2011-02-08" version="1">MNFKNNEEDYIKTIFSLCEAFGSANENMVSKDLGVSMATVSEYLSKLEGKELITRKNRDIYLTKQGYSMAIPVIRKHRVSEVFAVKMLEVPWEYSHSAVMDIEHTIEDKYFDTFSKNLGNPLTCPHGNMIYFNHEIKDINALTANSGKYKLNRIVYENTDILKKLADFGMYPGTPIEIFTDNNTVISNENGELKLPILWGKTIRLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-07" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q2PCE2</accession>
    <name>Q2PCE2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">o-succinylbenzoate synthase</fullName>
            <ecNumber evidence="5">4.2.1.113</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gly2</name>
        <name evidence="7" type="synonym">glyFa2</name>
        <name evidence="7" type="ORF">FAD_0492</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2006" name="Environ. Microbiol." volume="8" first="416" last="425">
            <title>The 'pH optimum anomaly' of intracellular enzymes of Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Golyshin P.N."/>
                <person name="Timmis K.N."/>
                <person name="Ferrer M."/>
            </authorList>
            <dbReference type="PubMed" id="16478448"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2005.00907.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Type strain: DSM 12658</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ850917">
        <property type="protein sequence ID" value="CAH64536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887548.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2PCE2"/>
    <dbReference type="STRING" id="74969.FAD_0492"/>
    <dbReference type="GeneID" id="16025695"/>
    <dbReference type="KEGG" id="fai:FAD_0492"/>
    <dbReference type="OrthoDB" id="372081at2157"/>
    <dbReference type="BRENDA" id="3.2.1.20">
        <property type="organism ID" value="10776"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016854">
        <property type="term" value="F:racemase and epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03317">
        <property type="entry name" value="NAAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010197">
        <property type="entry name" value="OSBS/NAAAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01928">
        <property type="entry name" value="menC_lowGC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48073:SF5">
        <property type="entry name" value="O-SUCCINYLBENZOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48073">
        <property type="entry name" value="O-SUCCINYLBENZOATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00180">
        <property type="entry name" value="muconate_cycloisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00009">
        <property type="entry name" value="o-succinylbenzoate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="6">
        <location>
            <begin position="136"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH64536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="361" mass="40507" checksum="48BAA6DAED3B1294" modified="2006-02-07" version="1">MKITYHKLKMPLISPFTTSFGTDVNKDVYVFKLEHNGITAYSESVTDENPFYGSEDNYTVFHIVKQYLAPVVKGLPEPDEFNEQVKFIKGNNMAKASMEMLLYDYYAKANKKSLVDYIGHSRGYANVGISLGMDDINVTLKKIQEALDRGYKRIKVKIMKGKEIGILSAVRDNFPDIVLSADANSDYTEKDFDLIKKIDRYNLVYLEQPLYHDDIIYHSRLAKGLSTPLCLDESITSPEKAQKAFEMGACKVINIKEGRLGGIGNSLKVMGIVKEFKGHVWIGGMLETGIGRSFNVSMASLSDINYPGDTSPNDKYFKNDIVKNPFTMENGTIKPNKGTGIGVEISEEYLKKYTVEEGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1F5</accession>
    <name>A0A1V0N1F5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0014</name>
        <name evidence="2" type="ORF">HLB00_05700</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000190">
        <property type="protein sequence ID" value="NOL60327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887025.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1F5"/>
    <dbReference type="GeneID" id="25398802"/>
    <dbReference type="KEGG" id="fai:FAD_0014"/>
    <dbReference type="OrthoDB" id="57337at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD83949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="193" mass="23256" checksum="0FF07EE7BAD5FD23" modified="2017-06-07" version="1">MDMHNVTINFPKNIVLENGESIHIERDKITDESLFSMLFPEKSTDRIAINLIKNGFHDATPSFFKGEKYSMAKEIAFPWELHIRLFNYGKQYGKMFAHVEISRKYFEHLFIIQPSVFEPFEFYKSIYREFNVMYEPSGKKVKEFKNYYKVKLIPPENLIEWMPLVLNLYSNFSQYKEKIREIIDVIDFELHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1H0</accession>
    <name>A0A1V0N1H0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfite dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sulfite oxidase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0034</name>
        <name evidence="3" type="ORF">HLB00_06515</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000231">
        <property type="protein sequence ID" value="NOL60485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887045.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1H0"/>
    <dbReference type="STRING" id="74969.FAD_0034"/>
    <dbReference type="GeneID" id="16025180"/>
    <dbReference type="KEGG" id="fai:FAD_0034"/>
    <dbReference type="OrthoDB" id="24039at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02109">
        <property type="entry name" value="arch_bact_SO_family_Moco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43032:SF4">
        <property type="entry name" value="OXIDOREDUCTASE MOLYBDOPTERIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43032">
        <property type="entry name" value="PROTEIN-METHIONINE-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="202" mass="23468" checksum="F7A07C1ED57BB1CF" modified="2017-06-07" version="1">MEKIEIKNPGQYYVNSWIIYDALGGPAIDENKWSLKVTGLVKKPAEYTYQELNKMDGIEYISDFNCVTKWSIKDAKFSGPSLKDLIMKSEPLPEAEWVMFVCADGYDTPIPFDDAVDEKSILALRIDDKPLGVKHGFPARPFMPSLYGWKSAKWVTEIKLMEKYEDGYWEAYGYHERGKVEDEERFKGFGWKKIKRHSEIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1H9</accession>
    <name>A0A1V0N1H9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2 11">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">tmk</name>
        <name evidence="13" type="ORF">FAD_0020</name>
        <name evidence="14" type="ORF">HLB00_05670</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Berkeley</strain>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>dTMP + ATP = dTDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2 11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000190">
        <property type="protein sequence ID" value="NOL60321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141240.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1H9"/>
    <dbReference type="STRING" id="74969.FAD_0020"/>
    <dbReference type="GeneID" id="84218510"/>
    <dbReference type="KEGG" id="fai:FAD_0020"/>
    <dbReference type="OrthoDB" id="43083at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF4">
        <property type="entry name" value="UMP-CMP KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="12">
        <location>
            <begin position="5"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD83955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="NOL60321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="206" mass="24133" checksum="3D9C3E8A21DBD7D5" modified="2017-06-07" version="1">MFITIEGIDGSGKTTLVNSLRKIFNNIHFTREPTDKFQLANLKTLSTPSNSFYNFFLFTYDRLEHQEEINGYKNVICDRYLASSIAYEGPMIEGLFGDRKETVLWMMEVSKMLKLPDMIIYLDANLDVALERIRNSRKNLNFRGKQLSILEEREGLKAIQDYYEYFLGNMKMFTQKQIKIEKIDANSSMEDVLYKAENIINKTIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1K5</accession>
    <name>A0A1V0N1K5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141307.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1K5"/>
    <dbReference type="STRING" id="74969.FAD_0085"/>
    <dbReference type="GeneID" id="31675597"/>
    <dbReference type="KEGG" id="fai:FAD_0085"/>
    <dbReference type="OrthoDB" id="39225at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF1">
        <property type="entry name" value="THREONINE-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="4">
        <location>
            <begin position="48"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="342" mass="38795" checksum="9F8B2C93739794F4" modified="2017-06-07" version="1">MHGGNIYDFARENQASLSSILDFSASISDFNRIKNFIIKKEYIENYPETNLAAYKKILASNEFNPANISLVSGLTAFIHTFLASIKGNVIIISPSFTEYLKPQIEGKRIIIPFNVLNGHPEILSNFNFEALFLVYPDSPTGQLMSSSSIYTIIEIAMKKNSTVFLDESFIWFVNDREIIERELIEKYNNVIIGRSMTKILSIPGLRLGYIASNSTTIHNIEEKLEPWRINQAALAYIDGNIQDLSNVARSTETERNYLIKSLKNMGFRTVGKPRANYITFQLPGNIDGPQLKAYLAGKNIMIRLLDDYNEFGSNYMRISVKKRVKNKVLINALSYYTGDIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1L2</accession>
    <name>A0A1V0N1L2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141346.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1L2"/>
    <dbReference type="STRING" id="74969.FAD_0110"/>
    <dbReference type="GeneID" id="31675622"/>
    <dbReference type="KEGG" id="fai:FAD_0110"/>
    <dbReference type="OrthoDB" id="57062at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="entry name" value="DsrEFH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37691">
        <property type="entry name" value="BLR3518 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37691:SF1">
        <property type="entry name" value="BLR3518 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DsrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="DsrEFH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="111" mass="12317" checksum="AC37C324B295DB26" modified="2017-06-07" version="1">MYNVIVCGNDYSIMKTILKQIGNLKNSMPDANIEVVFNRSAVKALLKGDEFMPKIKEIIDSGVKINACKNTLKEMKLSEDDVDKGSGIGIVTAAVEEIVRKQAEGYFYLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1L6</accession>
    <name>A0A1V0N1L6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0147 protein FAD_0064</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0064</name>
        <name evidence="5" type="ORF">HLB00_07385</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0147 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141279.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1L6"/>
    <dbReference type="STRING" id="74969.FAD_0064"/>
    <dbReference type="GeneID" id="84218554"/>
    <dbReference type="KEGG" id="fai:FAD_0064"/>
    <dbReference type="OrthoDB" id="65304at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="entry name" value="Ta0600-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00342">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005354">
        <property type="entry name" value="UPF0147"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003319">
        <property type="entry name" value="PRK04330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03685">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158436">
        <property type="entry name" value="Ta0600-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD83997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="85" mass="9426" checksum="DBCEF5E3725B261D" modified="2017-06-07" version="1">MDENLFNEVLALMDDLEDDSSIPRNVRKTSSEAKEKMKDGKESLDLRCATVISELDDISNDPNVPSHGRAAIYTIISKLEALSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1R7</accession>
    <name>A0A1V0N1R7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0148</name>
        <name evidence="3" type="ORF">HLB00_07165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000260">
        <property type="protein sequence ID" value="NOL60607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887153.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1R7"/>
    <dbReference type="GeneID" id="58788974"/>
    <dbReference type="KEGG" id="fai:FAD_0148"/>
    <dbReference type="OrthoDB" id="378004at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="51" mass="5673" checksum="C677A6C38481454B" modified="2017-06-07" version="1">MIPDILTAMITLHPAAYNPNTETFFLEVIMGMCAAITIGATIFVKEFILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1R8</accession>
    <name>A0A1V0N1R8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="8">PRAI</shortName>
            <ecNumber evidence="8">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpF</name>
        <name evidence="10" type="ORF">FAD_0103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795605.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1R8"/>
    <dbReference type="STRING" id="74969.FAD_0103"/>
    <dbReference type="GeneID" id="31675615"/>
    <dbReference type="KEGG" id="fai:FAD_0103"/>
    <dbReference type="OrthoDB" id="27513at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002302">
        <property type="entry name" value="PRK01222.2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894:SF1">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="9">
        <location>
            <begin position="3"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="199" mass="22231" checksum="26B3ABFA21FF2D58" modified="2017-06-07" version="1">MKVKVCGITRIEDAEYAIKMGADLIGVILDPEVGRHGSQALIREIKTKYPSTPVAGVYTSMPEHSGYEDYIQLHFNHSEEDIIAAKKAFNKKIISVIDFHVDGIADKVDSHMKSGAEIILLEDRSGIINRIDQVKELPGDRLGIAGKIDSNNVQKLLATDPYLVDVSSSLEEYTGKKSFKKIDEFFNKIGEYYAVRQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1S3</accession>
    <name>A0A1V0N1S3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887144.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1S3"/>
    <dbReference type="STRING" id="74969.FAD_0138"/>
    <dbReference type="GeneID" id="16025283"/>
    <dbReference type="KEGG" id="fai:FAD_0138"/>
    <dbReference type="OrthoDB" id="148073at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.90">
        <property type="entry name" value="AF1782-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="AF1782-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF357" evidence="1">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="94" mass="11106" checksum="A1346625C5D78DEB" modified="2017-06-07" version="1">MELKEKVEKYFEIEKAALDKIRIIAPVDSYIYGIAKDHMDMVLNYYNDAKYFYSKNDFINAFAALNYSYGWIDSAIRIGLFDGNSDHRLFTHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1T5</accession>
    <name>A0A1V0N1T5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein translocase subunit SecY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein transport protein SEC61 subunit alpha homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">secY</name>
        <name evidence="15" type="ORF">FAD_0182</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141387.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1T5"/>
    <dbReference type="STRING" id="74969.FAD_0182"/>
    <dbReference type="GeneID" id="31675693"/>
    <dbReference type="KEGG" id="fai:FAD_0182"/>
    <dbReference type="OrthoDB" id="371914at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="14">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD84112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="586" mass="63746" checksum="B7A0E5ECD9694A78" modified="2017-06-07" version="1">MTEIRRNKGAAIPVIFIFALFIVVFYYFSHYTGLKLFILGLLSSPLFIIAYLLLSYKGPKKSRLYGLENLTAKLPAIKKAKGHVPFKYKLMWTAVVVLIYFALTNIYIYGLNTSKTVDVFASFRAIFAGASGSLMDLGIGPIVTASIVMQLFAGAKIFNLDLSDSSDKAIYQGFQKLLVIIMIFVEAIPQAFGFLVPDAGLVSNIAHVVPGYGEFLAQSIIILQLFFGSYLVFLMDEVVSKYGIGSGISLFIAAGVSQQLFTGTFNWIPSTITSPLSLSNPPAGAIPKALYLFINAPGSYLTNTGMEQILFAQPNPMIALVGTLLIFFVVAFFQSSKIELPIAHERVRGARGRYPLQLLYASNIPVILATALLANISMWTLLFWDSPVLSKIPILGHSHLLGSYASAAQISTLGISSTTPTGGLAYYLYTPNGLSDWLFPILQPSVSQSVLLGHTPVEELIHIVVFMVFLVGFSILFAKFWIETTNMGPDAVAKQIRSSGMQIPGFRRDPRIMAKVLSKYIPAITIFSGAIVGILAGAADLIGTVGDTSGTGLLLAVGIVIQFYEAMGREQLMEMHPLIRQFFNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1T6</accession>
    <name>A0A1V0N1T6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-dehydroquinate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1T6"/>
    <dbReference type="STRING" id="74969.FAD_0125"/>
    <dbReference type="KEGG" id="fai:FAD_0125"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050146">
        <property type="entry name" value="Type-I_3-dehydroquinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43699">
        <property type="entry name" value="3-DEHYDROQUINATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43699:SF1">
        <property type="entry name" value="3-DEHYDROQUINATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="229" mass="26771" checksum="DA4D66674DA7C712" modified="2017-06-07" version="1">MSVVYSIMPENSCIIYTSMFFPDSRQMKLEFDKNKDNFKGHYEIRYDLFNDKSLKNLEDMLMYLNSHKVDYIFTFRSADKNEIEKVYGTALKFNPPVIDIDIKSFIFNKNIFNNSKLMISFHGDNNDDVPALLEDMSEFNPDIYKIALAYTDIEKFLKDLNYLYAYRKKNGIKLAYIPMGSENSFLRVVSAYLVSDYSYASYTQPTAPGQISKEQFQAVLEMFRPDTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1U9</accession>
    <name>A0A1V0N1U9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5611 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141367.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1U9"/>
    <dbReference type="STRING" id="74969.FAD_0130"/>
    <dbReference type="GeneID" id="31675642"/>
    <dbReference type="KEGG" id="fai:FAD_0130"/>
    <dbReference type="OrthoDB" id="56086at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040713">
        <property type="entry name" value="DUF5611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016800">
        <property type="entry name" value="UCP022080"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18446">
        <property type="entry name" value="DUF5611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022080">
        <property type="entry name" value="UCP022080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5611" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="95" mass="11155" checksum="B3AEB90D959B0EB9" modified="2017-06-07" version="1">MRTYPVKKTIKINETYVMETLKSRNLEFQQEGDHIISSYPGLKKIELWTDGKKLYVETETDTQYSNPGETIKFFNNLLEALTGYTTKERKKLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Z7</accession>
    <name>A0A1V0N1Z7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">50S ribosomal protein L15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0181</name>
        <name evidence="6" type="ORF">HLB00_02325</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000069">
        <property type="protein sequence ID" value="NOL59670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887186.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Z7"/>
    <dbReference type="STRING" id="74969.FAD_0181"/>
    <dbReference type="GeneID" id="16025329"/>
    <dbReference type="KEGG" id="fai:FAD_0181"/>
    <dbReference type="OrthoDB" id="9418at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="135" mass="14949" checksum="FC504063FB276EBC" modified="2017-06-07" version="1">MVRTKTKKLRGGHYGRGMKSGRGKGKRGGSGMAGLGGHKKIWLIIHDKNHYGVHGFTSHSTTYENPITLRQLNDRYEVLKASGYVENDVIDLESAGYTKLLASGNFEIKCKIKIPKATEKSINKLSNHGITIEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N210</accession>
    <name>A0A1V0N210_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">FAD_0207</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 25">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141403.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N210"/>
    <dbReference type="STRING" id="74969.FAD_0207"/>
    <dbReference type="GeneID" id="31675717"/>
    <dbReference type="KEGG" id="fai:FAD_0207"/>
    <dbReference type="OrthoDB" id="6009at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019969">
        <property type="entry name" value="RNAP_Rpo2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006335">
        <property type="entry name" value="PRK08565.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03670">
        <property type="entry name" value="rpoB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 15 23" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="15"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="207"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="458"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="552"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="635"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="724"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1098"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ARD84135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1195" mass="134947" checksum="44BC97A47D124A6F" modified="2017-06-07" version="1">MNPILDAFFKSESVVNYQIDSMNYFYASKNNPDNIMQQIVDETKISDDATPGVIDLDPSKTKGKDIKIYFGRERQNGKATGDPTIWVDKPEIKEASGATNQITPQEARLRDLNYMAPIMLRLRIVEDGIERDANTIKIGEIPVMVRSKICTLSEQNLDLYIEKNNGPIDETRENKLRYVDEDPTDPGGYFIIGGSERVIVSLEDLAPNKILVEYEEKYDSRVEVAKIFSQKSGFRALISMEKGSDGIINVSIPTVAGTIPLVILMKALGIDKDVDIHEAIYTDPRMDPLIYANIEDSRNLKILPPNGINNNEDALSYLKKRFAAGQAKEFRDKKITQMLDRALLPHLGDDVSDRLKKAIYLGRMARSLLELNLGMRHVDDKDHYANKRIKLSGDLLDELFRNAFQSVMKDLKYQLEKTYNKKRGIRLRPAVRQDLLTQKVLHSMATGNWIGGRTGVSQLLDRTSNMSTLSHLRRIISPLTRSQPHFEARDLHPTQWGRICPNETPEGQNCGLVKNASLIINVTQGIDPDIVMEELQNMDIHEVTKEEASGRIYLNGDFIGYHNDPAILTDTIRNLRRSGKLSNEVNVKYDSNTNEVIINCDRGRLRRPLFVVNEGKTVMNEEMLEKLRMGEYTVNDLISSGAIEWLDAEEEENAYISVFPFEFPDNCPDCGKVLYRDNVTWINPGNSDVTLECDECHAHFKGTNNLSMDHTHCEIDASMILGVVASLIPYPEHNSSPRITIASAMIKQSIGLPQANYRIRTDTRGHLLHYPQIPLVTTKVMDFIKYRRKPAGQNFVVAIVSYHGYNMQDAIIMNKASIERGLGRSSFFRTYTAEERRYPGGQEDKFEIPSHDVLGARAEEYYKNLDENGIIFPESKVEGSDVLVGKTSPPRFLEEENADKLGPLRRRESSVTVRPTESGYVDNVFLTVSESNSRIIKVKVRSDRIPQPGDKFASRHGQKGVIGYVAAQEDMPFTEDGIIPDLLFNPHSVPSRMTLGHVLEMMGAKVSTMSGENIDSTIFDGEPERSLREQLKKYGFRESGNEVMYDGITGKKFEVDIFMGVIYYQKLHHMVASKFHARSRGPVQILTRQPTEGRSRQGGLRFGEMERDTLIAHGASMVIKDRLLDQSDGTILYVCGNPTCGHIAIYDFRKGTLRCPACGNTGNIYPIETSYAFKLMRDELSSMGIVMRLELGDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N224</accession>
    <name>A0A1V0N224_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141412.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N224"/>
    <dbReference type="STRING" id="74969.FAD_0216"/>
    <dbReference type="GeneID" id="31675726"/>
    <dbReference type="KEGG" id="fai:FAD_0216"/>
    <dbReference type="OrthoDB" id="31271at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051720">
        <property type="entry name" value="rRNA_MeTrfase/Polyamine_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290:SF0">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="3">
        <location>
            <begin position="37"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="205" mass="23241" checksum="65E165CF0A31B2F6" modified="2017-06-07" version="1">METRRNKINKKALEIFLSRLEKPDFYNINLEQYPTDADTASTLLIEAYMDGNIAGKNVIDLGTGNGIFAIGASYLGAKVSTGIDIDPEMVATSRKNAENNASDAEFANVDVSDVKGEYDTVLMNPPFGSVIKHDDMPFINKAIEIGTHIYSIHNIKSYEYIREFYSQRIQIIRQERIFIKVPRIYAHHTDNYHEIESVLVYGIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N259</accession>
    <name>A0A1V0N259_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">xerD</name>
        <name evidence="9" type="synonym">xerA</name>
        <name evidence="13" type="ORF">FAD_0291</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141457.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N259"/>
    <dbReference type="STRING" id="74969.FAD_0291"/>
    <dbReference type="GeneID" id="84218791"/>
    <dbReference type="KEGG" id="fai:FAD_0291"/>
    <dbReference type="OrthoDB" id="142231at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02055">
        <property type="entry name" value="Recomb_XerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033686">
        <property type="entry name" value="XerA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040815">
        <property type="entry name" value="recomb_XerA_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349:SF77">
        <property type="entry name" value="TYROSINE RECOMBINASE XERC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="98"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD84213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="280" mass="32691" checksum="D3C8131368B2BDC8" modified="2017-06-07" version="1">MDINRELKSFERFMITERKSYYTIKEYKFLISGFLSYCNKDLSSIDFDDVENYKNFIVTEKQYSKASQYLAMKALRLYYKFKNKDTPPNLIPPRRSQKMPVYLNQKDAGVLINGAKSIRDIAVISVFLYTGIRVSELTNLQIGDVDFDENIIYIHAGKGDKDRIVVMPDICREHIKSYMKERIRIKSSNNYLFISNKKTKFDTSTVERMVKRVAKNAGITKNVTPHVLRHTFATSILRNGGDIRFIQQILGHSSLATTQIYTHIDDNTLKEMYSRHMPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N289</accession>
    <name>A0A1V0N289_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887339.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N289"/>
    <dbReference type="STRING" id="74969.FAD_0321"/>
    <dbReference type="GeneID" id="16025485"/>
    <dbReference type="KEGG" id="fai:FAD_0321"/>
    <dbReference type="OrthoDB" id="23530at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="4">
        <location>
            <begin position="193"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="303" mass="34325" checksum="E06CCE8C5F2A07E6" modified="2017-06-07" version="1">MEHDFKIIDYIIKGNETHDGAGVKLKRIFGGPNTVQLTDPFLLLDHFGSDRIEDYIAGFPWHPHRGIETITYLLSGKVEHRDSTDHRGTIYPDELQWMTAGSGIFHEEMPKPLDEKNPEELIKAYGMPTLVSGFQLWLNLPAKYKMSTPAYRSIKGSEVPKIEIDGATLKIIAGEYNKVSGMYNSQYGIDPLYLDITMDEDSDFVYRVKDGYTSLIFSITGEGISNGQKLEPDTAAIMSRNGNFIKIHTGNSKYRFILLSGKPLNEPIKWYGPIVMNTDEQIREAISDLNNNNFVREKNPIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N297</accession>
    <name>A0A1V0N297_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0305</name>
        <name evidence="2" type="ORF">HLB00_09400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000411">
        <property type="protein sequence ID" value="NOL61033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141476.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N297"/>
    <dbReference type="GeneID" id="31675814"/>
    <dbReference type="KEGG" id="fai:FAD_0305"/>
    <dbReference type="OrthoDB" id="41324at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL61033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27950" checksum="C18AA4F43EC73495" modified="2017-06-07" version="1">MKFAVPGFDVVSDFYGSISGVKLTVPGSQWFIIPSIISYFTSQGVKTYFETLPEVYIRKRANGSPITIGNLVIENRPEIICQSNRLIHDMKAMERKEAFEDALCVAYTGKKKQVSISELKNFRFAIPNPRTSATGIAFKNYYEEKCGYYGELKENTAICDVPNREIPKKLINGDVDYGIMLKSEANYWKFRHYFPDVVKEKFSWLLLENASPAAIDVFHTIESGTFNEYYARYGYITADRAKSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2C1</accession>
    <name>A0A1V0N2C1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2-type family transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141502.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2C1"/>
    <dbReference type="STRING" id="74969.FAD_0323"/>
    <dbReference type="GeneID" id="84218821"/>
    <dbReference type="KEGG" id="fai:FAD_0323"/>
    <dbReference type="OrthoDB" id="87732at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03230">
        <property type="entry name" value="ABC_DR_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050763">
        <property type="entry name" value="ABC_transporter_ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42711">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42711:SF5">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="304" mass="33897" checksum="B06329A5FC0C5233" modified="2017-06-07" version="1">MEITFNKVTKKYHKFMALDDVSFNYRDHGAIGYLGPNGAGKTTTLKVMTNLLRPSEGHAELNGIDVNKYPKKALANVGSMIETPTPYPFLTVKESMQFVGELRGIDKKTINSKIDEFYDALKLPPLTSKMGQLSKGQRQRAVFASVLISDPDVVILDEPTSGLDPFERKIFRDFILELKKTKLVFFSSHILSEVSETCDDVIFINHGKILKQGKIDEIAQEFNTNAVSIEFLKPLDNNMIKNIRSLGSGVLKTDGKYAVIKFSGKEDERAQILENAIKLAPIISYTSYGSDLESAYLSILGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2F0</accession>
    <name>A0A1V0N2F0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylated-DNA--[protein]-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.63</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="9">O6-methylguanine-DNA methyltransferase/endonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0403</name>
        <name evidence="10" type="ORF">HLB00_05050</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141572.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2F0"/>
    <dbReference type="STRING" id="74969.FAD_0403"/>
    <dbReference type="GeneID" id="84218914"/>
    <dbReference type="KEGG" id="fai:FAD_0403"/>
    <dbReference type="OrthoDB" id="372118at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511:SF1">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="8">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL60203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="303" mass="34198" checksum="3DE97DC30A1009FB" modified="2017-06-07" version="1">MNYTHINLYDYFYSLVKQIPEGYITTYGELAKALGDIRAARAVGYMLSINEDPDRIPCYKVVHTDRRMGKYALGVEEKARRLRKDGIIISNGMVENFNERFFSDFKTDYPLAKLQEEQEKIASMADFAGDRDEENYAAIDVSYEGRTGYGALVYYNSGEYMVKNLEMKVNFPYIPGYLGYRESPFIEKLSVNVDGLLLIDANGLLHPRKCGLATFAGVVLGRATIGVAKSLLMGKIDDTGYVVYNNEKLGYAINKHTIVSPGNMISLESSIKKIKLLGKNKYPAILKMVHNETVAMRKRRLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2G3</accession>
    <name>A0A1V0N2G3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMP synthase [glutamine-hydrolyzing] subunit A</fullName>
            <ecNumber evidence="8">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">guaAA</name>
        <name evidence="10" type="ORF">FAD_0422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940592.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2G3"/>
    <dbReference type="STRING" id="74969.FAD_0422"/>
    <dbReference type="GeneID" id="31675931"/>
    <dbReference type="KEGG" id="fai:FAD_0422"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000047">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing] subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01510">
        <property type="entry name" value="GMP_synthase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023686">
        <property type="entry name" value="GMP_synthase_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001975">
        <property type="entry name" value="PRK00758.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="188" mass="20906" checksum="92A492DC6AC4CAD9" modified="2017-06-07" version="1">MKIGVIDNGGQWTHREWRVIRSFGVDSEIYPNTVENTSLDGLDGLVLSGGPASIDSEVGKLGYIKQYIETHSYPILGICVGAQFIALNSGATVSKAIHPEYGKKKVTFIKSESIFAGMPETINAWESHNDEIKNLSDEYVLCASSDTCKVQAFYHKTKDIFAVQFHPEVNNTEHGTEIFKNFIDVCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2G4</accession>
    <name>A0A1V0N2G4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0365</name>
        <name evidence="2" type="ORF">HLB00_03480</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000112">
        <property type="protein sequence ID" value="NOL59895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887384.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2G4"/>
    <dbReference type="STRING" id="74969.FAD_0365"/>
    <dbReference type="GeneID" id="16025530"/>
    <dbReference type="KEGG" id="fai:FAD_0365"/>
    <dbReference type="OrthoDB" id="57000at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="77" mass="8554" checksum="0608287F10515697" modified="2017-06-07" version="1">MKCSTPDCAGEMEPAGNMNFRVGGYTGIGGMFLGGWNDLTETTQTFTLYKCNTCGKVELYEPQPVQDDRGEKKHHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2K0</accession>
    <name>A0A1V0N2K0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P protein component 4</fullName>
            <shortName evidence="8">RNase P component 4</shortName>
            <ecNumber evidence="8">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rpp21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnp4</name>
        <name evidence="9" type="ORF">FAD_0406</name>
        <name evidence="10" type="ORF">HLB00_05035</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887438.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2K0"/>
    <dbReference type="STRING" id="74969.FAD_0406"/>
    <dbReference type="GeneID" id="16025584"/>
    <dbReference type="KEGG" id="fai:FAD_0406"/>
    <dbReference type="OrthoDB" id="10058at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00757">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016432">
        <property type="entry name" value="RNP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004878">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL60200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="93" mass="11061" checksum="B0EA8E9FF5259705" modified="2017-06-07" version="1">MKDRVLINISKERMQTLFNEAENTENIALARRYIRLMEKIGMRMNISVNTSIKHSYCKHCKTPYKNPGIKLKNKMVQVRCPYCGEIRRIPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2K4</accession>
    <name>A0A1V0N2K4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF302 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0475</name>
        <name evidence="3" type="ORF">HLB00_08860</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000332">
        <property type="protein sequence ID" value="NOL60929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887530.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2K4"/>
    <dbReference type="STRING" id="74969.FAD_0475"/>
    <dbReference type="GeneID" id="16025679"/>
    <dbReference type="KEGG" id="fai:FAD_0475"/>
    <dbReference type="OrthoDB" id="2559at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14797">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="entry name" value="TT1751-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016796">
        <property type="entry name" value="UCP021774"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38342">
        <property type="entry name" value="SLR5037 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38342:SF1">
        <property type="entry name" value="SLR5037 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021774">
        <property type="entry name" value="UCP021774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="TT1751-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="124" mass="14137" checksum="FDD9C09F6F8DB5AA" modified="2017-06-07" version="1">MYSYEKTLNKSAEEVFGGLHKLLKEANWLIISYIDLKEIFSKMQKEIEPYYILDVCFPPAAAELVKDNEDIGAFIPCKVVLIQHGNTTKILMPKPSVLSKEYLDTDGKVAEKYETTLMGMLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2M7</accession>
    <name>A0A1V0N2M7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2M7"/>
    <dbReference type="STRING" id="74969.FAD_0423"/>
    <dbReference type="KEGG" id="fai:FAD_0423"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="201" mass="23580" checksum="5BCC6141711AE92C" modified="2017-06-07" version="1">MNGERYFYYIKLINNPPDNSVVEYYVDLSAQLENDYELSVSQITELESLIGNYIKMKANPHIKVINAVTGIEEDPPRTKIDDFGGNAVFIGKEIRHGIEWDVYEPRASNNLFFKKWYYNERIASILDKTLEKAIPHRIPNYFDIPPWIFGNFSYRGIRYVPLAEIINNAIELEIIPNKYYLVQKGISREFIDNINDSNMWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2N2</accession>
    <name>A0A1V0N2N2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine dehydrogenase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141608.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2N2"/>
    <dbReference type="STRING" id="74969.FAD_0450"/>
    <dbReference type="GeneID" id="31675959"/>
    <dbReference type="KEGG" id="fai:FAD_0450"/>
    <dbReference type="OrthoDB" id="17655at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001696">
        <property type="entry name" value="PRK00451.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM P-PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006815">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="429" mass="47653" checksum="6C4DC908DEFA5FB3" modified="2017-06-07" version="1">MSETDEILDYLNVKSVDGLFSDIPDRLKVSLDLGKPIDEFSTIRAIEDMGRKNKAGNMNFLGNGIYDRFVPPLVDEIIGRNEFLTSYTPYQPEISQGILHSLFEYQSIISDLTEMDITNSSMYDGFTSLAEAVRMAYRINGKSEVLIPENIYKSQLSIIKNYTEGLNLKIITYGFGTDGLLDLEDLKSKVTSDTSAIIVENPNVFGLIDENAFHVSEIKKDSILITYYDPVSLGFIIPPGEYGTDIAVAEGQQLGIHMNYGGPLLGLFSFKKEYVHRSPGRLIGLSKDSEGKKAFVMTLQAREQHIRRSRAMSNICSNQALLAVASLAYLSIMGSEGLRKIALITMNKSRKLKNNMKSAGIKPVFDGINFSDNLFYFDQLEILESNNISGGIRLSSISEYNGYGNASFFSVTEKTGDENIEKLAKILGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2P6</accession>
    <name>A0A1V0N2P6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-aminoadipate--LysW ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysX</name>
        <name evidence="9" type="ORF">FAD_0508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887566.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2P6"/>
    <dbReference type="STRING" id="74969.FAD_0508"/>
    <dbReference type="GeneID" id="16025712"/>
    <dbReference type="GeneID" id="31676016"/>
    <dbReference type="KEGG" id="fai:FAD_0508"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043774">
        <property type="term" value="F:coenzyme F420-2 alpha-glutamyl ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000058">
        <property type="entry name" value="Alpha-aminoadipate--LysW ligase LysX protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054562">
        <property type="entry name" value="LysX/ArgX_preATP_grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="Rp_bS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621:SF2">
        <property type="entry name" value="COENZYME GAMMA-F420-2:ALPHA-L-GLUTAMATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 MODIFICATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22626">
        <property type="entry name" value="LysX_preATP_grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="92"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="282" mass="32497" checksum="0FC910B4A5E86BEB" modified="2017-06-07" version="1">MKISMLFDIMRWEERAILKALQDKNVEVQLYNVKEMNLDLQDPNYDFGDISLQRSTGYYRNLHSTAYVEFTGNRIINDFNSTIVTGNKMFTSLLLSQKRIRIPKTFVSFSNERFLKSFKEDFNGRAVTKPVTGSWGRMISLLNDYYAAMDVSEYKDYMYPLYQINYTQEYVNDFGRDLRVFIVNDQVIAGIYRYKSGEDWRTNTALGGRAEPLKITGEVEEIAQKVSAALGPGIYGMDILESKDGYFVNEVNGNTEFKNTVPVTGINIPDYIADYLISEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Q8</accession>
    <name>A0A1V0N2Q8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">kdpA</name>
        <name evidence="10" type="ORF">FAD_0518</name>
        <name evidence="11" type="ORF">HLB00_00545</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000014">
        <property type="protein sequence ID" value="NOL59328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887576.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Q8"/>
    <dbReference type="STRING" id="74969.FAD_0518"/>
    <dbReference type="GeneID" id="16025722"/>
    <dbReference type="GeneID" id="31676026"/>
    <dbReference type="KEGG" id="fai:FAD_0518"/>
    <dbReference type="OrthoDB" id="56688at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE A CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607:SF2">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE POTASSIUM-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL59328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="553" mass="58961" checksum="CC7DB64E77443431" modified="2017-06-07" version="1">MIGPYYFLIIALVWAIVVLLAWILAKYLQGVYDSGKTIFDKIMDPVDNVIYKILGIDKNQEMGWKEYFLSLFIFSIFTAIISFLVLSFQGVLPLNPMKFAGLKWPLALNTALSISSNTNLQHYAGGSSLSYLGQMAGIQSLQFTSAATGLAVAVAIFRGFVGKKDEKSKLGNFYVDLIRSITRVLLPLSIIGAIIVIALGVPQSLSGYDLTTSLSGISQIIKVGPVGSLVSIMQLGTNGGGYFGANSAYPLQNPGPLSNYVELGMMMLIPTSMPFLFGGMLRNRNEGRTILLASYTLYAIDLAIALIPVTTLGAGMETRFGGFSPVLWTVTTTAFTTGSVNTSLAAMHPLVILAAFMGMIIQATPGGIGVGAMYMLMYIIITVFIVGLMAGRTPEYLGGKITAGDVKLAVIAFLAHPIIILVPTALAYATGAVHGIGLGSGPVGFTQILYEFTSSAANNGSDYLGTQANTTFFNVSTGIVMWAGRFIPILIMLAIAGRMHEKKRSSEAALRTDGLVFPAILIVSIFILAVLTFFPFLAIGPILMHLEGIGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2R6</accession>
    <name>A0A1V0N2R6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141648.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2R6"/>
    <dbReference type="STRING" id="74969.FAD_0514"/>
    <dbReference type="GeneID" id="84217097"/>
    <dbReference type="KEGG" id="fai:FAD_0514"/>
    <dbReference type="OrthoDB" id="275197at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="108"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="215"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="359" mass="40234" checksum="109BBB94B782E2B7" modified="2017-06-07" version="1">MFEEYDEYRNKIREFALKEFTEDVAADYDRKEAYPDELRKKSLSLGIVDMQNPAKVMIGIEELCRVDAGLGIALTTPYFGSEVIMLFGSDAQKAILEDVYKGKYILGLGVTEPSGGSDVAGLKTTAKKQGNKYILNGSKMFITNGSIADYLVVLARTSEDSNPHHGLSTFLVNTKLKGFKANKLVDKLGVRATNTAELQFNNIELSEDDLIGEEGKGFYYIMMFFNISRIYVAAQSLGIARGAFDKIKSYIKENNIKDEESMFRLSDVGTRIEATRQMTYNAATYLFEFKPKPELTSMAKAYGSETAVYAAESAMEILGDHSAYEDVQRIFRNAKIMEIWEGTSEIEKLVIARYILKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2T2</accession>
    <name>A0A1V0N2T2_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">FAD_0500</name>
        <name evidence="2" type="ORF">HLB00_09610</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
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    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2T2"/>
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    <dbReference type="GeneID" id="16025703"/>
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    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL61073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="120" mass="13794" checksum="9572F29FF7EA296E" modified="2017-06-07" version="1">MSNKSKAVALSDILRYMADKIEETPDIAENLKIDVKLKQDKPVAMKIDLSGYDTEEKLYNALKKKNIKELKSIIKENKLGKDSSTSKLTTRSDLIKFIIKRVNDRYHKGDSFSRSMPEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2V4</accession>
    <name>A0A1V0N2V4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0570</name>
        <name evidence="2" type="ORF">HLB00_04170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887627.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2V4"/>
    <dbReference type="STRING" id="74969.FAD_0570"/>
    <dbReference type="GeneID" id="16025777"/>
    <dbReference type="GeneID" id="31676074"/>
    <dbReference type="KEGG" id="fai:FAD_0570"/>
    <dbReference type="OrthoDB" id="57185at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="80" mass="9382" checksum="611DCE081D840B5D" modified="2017-06-07" version="1">MYKCDDIKEIRVRYADETDRELSAEEIKEACNKANEANDSIERVLMKKEPKEVRYVEINPKKYTTLKNEAGTVLKPMPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2V8</accession>
    <name>A0A1V0N2V8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0571</name>
        <name evidence="8" type="ORF">HLB00_04175</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000142">
        <property type="protein sequence ID" value="NOL60030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887628.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2V8"/>
    <dbReference type="STRING" id="74969.FAD_0571"/>
    <dbReference type="GeneID" id="16025778"/>
    <dbReference type="GeneID" id="31676075"/>
    <dbReference type="KEGG" id="fai:FAD_0571"/>
    <dbReference type="OrthoDB" id="8730at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="150" mass="16835" checksum="744EA076A780269E" modified="2017-06-07" version="1">MICITGIPGSGKTTICKMLNANGIKCTGLNDIASECGALNGNTVDVDVLRRENINSEVVESHYSHMLECKYVIILEDNEEQLIRRMKSRGYPESKIKENIDAQRSGVIYWEASDRLPANHIFVVHEDSRSINEVFKDVMGIILSLHDKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2X4</accession>
    <name>A0A1V0N2X4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141645.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2X4"/>
    <dbReference type="STRING" id="74969.FAD_0512"/>
    <dbReference type="GeneID" id="31676020"/>
    <dbReference type="KEGG" id="fai:FAD_0512"/>
    <dbReference type="OrthoDB" id="35688at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016877">
        <property type="term" value="F:ligase activity, forming carbon-sulfur bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004837">
        <property type="entry name" value="PRK06187.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF11">
        <property type="entry name" value="MEDIUM-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="439"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="525" mass="59299" checksum="C26C234ECDF35222" modified="2017-06-07" version="1">MADFKLTINNLLDSAVRANGDQKIIYKDLQLTYNSFYKNVKNFAANLVKIGVKPGDRIAVIDYDTINYMYCYYSIPMIGAVIHMVNIRYPPEILYYTIKNSEDTYIVVNSDFMPLLMQFKNMFEFIKGFIVYSEHGHENYQLDNVYYADDLLKDTDYNITPPDENDMATLFYTSGTTGLPKGVYYNHRQLVLHSMATAEGLSDDPILLNKTSILLPLVPMFHVHAWGMPYFAIMKGLKYVLPGKYEWDRIVETMEKEHVTNSAMVPSILYLLLQAKRGPEVLGKLKLKSVIGGAALNEGLARSAESIGMSLVTGYGMSETCPILTLASYTNDILPLSEEIKEKYRRKTGVPVPMVNLRVVYQGKDVAKDDTEIGEIIVQAPWLTAGYLKDPEKTAKLWIDGWLHTGDLATMDKYGYIKIVDRESDAVKSGGEFIPSMVLEDLISTVPGVGEVAVTKKSDEKWGERPVAFIKGTATVEAIKEHMQQFVDTGRIAKFWLPDDYIFVDDFEKTGTGKINKVVLRKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Y0</accession>
    <name>A0A1V0N2Y0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Benzoylformate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141661.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Y0"/>
    <dbReference type="STRING" id="74969.FAD_0543"/>
    <dbReference type="GeneID" id="84217141"/>
    <dbReference type="KEGG" id="fai:FAD_0543"/>
    <dbReference type="OrthoDB" id="6837at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="184"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="380"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="513" mass="57249" checksum="54A4E3D7BB2A4EF5" modified="2017-06-07" version="1">MKGYEILEKTLDALKLDPVFGNPGTTEIPMLRGIRNYYLTLHDSIALGMADGYAQYNNTASIVNLHTLPGLGNAMSFLNTAKWNRSPVVITAGQQDTRHIVFDPLLSGDLLNTVSGLVKYSYEIKNPSDIPTAFRRAKAIAMTPPMGPVFISVPMDMMDYTAENLYFNDVRTNVSSYDPEAVLEIAERINKAKHPALVFGYEIDVYNAYAEAEAFADRLGVEVYSEPLASRGTFNTASEHYAGDLLPASTLMNLKFVNNDLIVFIGGDITFYPYLPSLPFPGKDVIFIGTDISHKTGDGYTMNPKLFLSEAVKLIKKKGDYKRSTDYLYANRVARQRLSMGVDYVLFKAKKLFSDYTIVDEAISASENVRSTFGYGYRKYYTAKSGQLGWATAAALGIGMNNKKTLVIIGDGAFMYTVQGLWTAKHYNIPVKFLVLNNSGYNILKSFSKSYYPDMEKKDYFQLNLDIESVAKGFGVETRTADENLSDLEWLRDGDVPKVLVVNTEKTVEKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Y5</accession>
    <name>A0A1V0N2Y5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">FAD_0534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887591.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Y5"/>
    <dbReference type="STRING" id="74969.FAD_0534"/>
    <dbReference type="GeneID" id="16025740"/>
    <dbReference type="GeneID" id="31676041"/>
    <dbReference type="KEGG" id="fai:FAD_0534"/>
    <dbReference type="OrthoDB" id="8967at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000034">
        <property type="entry name" value="Chaperone protein DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008035">
        <property type="entry name" value="PRK10767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010883">
        <property type="entry name" value="PRK14290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="141"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="141"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="367" mass="40016" checksum="F5FB456850AA091C" modified="2017-06-07" version="1">MSGDYYQILGVDKTASQEEIRSKFRELAKKYHPDVNSGSKEAEQKFKEIAEAYEVLSDPQKRQQYDATGSTTFGDAGAGGGAGFNWDNFSHFDDINDIFNTIFGGGFGRGNFNGSYGSSSPQPDLDIYVKLNVTMEDAYYGASKPIKFKRNAMCEVCNGTGAEGGVLVTCPTCHGTGQERISRGQGFFNFVQVIVCRTCMGKGKIPKTPCKACAGKGYIPKMENISITIPKGVDTNTRLRTQKLGNSFGGVTGDLYAVVYVQPNPNIKRTGDNLYVKEAIDFPTAALGGSVEIPLFKEKFTLNIPAGSQPEDVLRIKGAGMPKLTSRGSGDLLVVLKLQVPKHLTSREKELIEELKGEPVKKSWFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N303</accession>
    <name>A0A1V0N303_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">NADH dehydrogenase subunit N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887687.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N303"/>
    <dbReference type="STRING" id="74969.FAD_0629"/>
    <dbReference type="GeneID" id="16025836"/>
    <dbReference type="GeneID" id="31676134"/>
    <dbReference type="KEGG" id="fai:FAD_0629"/>
    <dbReference type="OrthoDB" id="29144at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004445">
        <property type="entry name" value="PRK05777.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22773">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="6">
        <location>
            <begin position="112"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="468" mass="52402" checksum="47B7AE782046573C" modified="2017-06-07" version="1">MNYEYLYALILLGLAGFITLAAGIKTDNKKILGGFTFIIMIVAFFIILFQVKNYSISSLNISSFDSYWALIFLVSIMVIIIPSMNDIKKRFDVYYAILLFTALSMIIAAFTYNLIILFISFEGVSIATYILTAYNKTKRNLEASLKYFMVSTVGTSFNIMGIAFFYLSTRTFNLNAITTIDFNRSLLLALVFITIGFGFKIAIFPMQQWAIDTYDGAPNSVSAFLSTGGKLVAYMILLKFLFLGFIPDYNYVFFFFAILAILTMTYGNLAALMENNLKRILAYSSIAQAGYMILVFALIGYSYYPAVLVSKEIFVKFAIASAMFYALAYIFMKAGPFIAMSLFKNDKVMIGDIAGLAKKSRYTALFLAIMLLSLAGVPLTGGFIAKYFLFFTLIIGNLWWLAVIAIINSAISIFYYFRIIIYSYRKEGDNDFNMAPGIKYSVIIMGLATLGLGVSFALYTYLVGIAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N307</accession>
    <name>A0A1V0N307_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0569</name>
        <name evidence="3" type="ORF">HLB00_04165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000142">
        <property type="protein sequence ID" value="NOL60028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887626.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N307"/>
    <dbReference type="STRING" id="74969.FAD_0569"/>
    <dbReference type="GeneID" id="58788987"/>
    <dbReference type="KEGG" id="fai:FAD_0569"/>
    <dbReference type="OrthoDB" id="56179at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="48" mass="5713" checksum="D5F1B95EB564CE8E" modified="2017-06-07" version="1">MGLGKRDLNRKRKSIEMKIDELEQKARKNPMDKSIQTEINDLKKKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N310</accession>
    <name>A0A1V0N310_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="5">Glu-ADT subunit E</shortName>
            <ecNumber evidence="5">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">gatE</name>
        <name evidence="7" type="ORF">FAD_0617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143142.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N310"/>
    <dbReference type="STRING" id="74969.FAD_0617"/>
    <dbReference type="GeneID" id="31676122"/>
    <dbReference type="KEGG" id="fai:FAD_0617"/>
    <dbReference type="OrthoDB" id="7316at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003107">
        <property type="entry name" value="PRK04028.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="GAD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartyl/Glutamyl-tRNA(Gln) amidotransferase subunit B/E catalytic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="617" mass="69433" checksum="28BDF9AC94DA6BF3" modified="2017-06-07" version="1">MKIGLEIHFQLGGNKLFCSCSTEGTELNESFTRKLTPVMGELGKLDTAVEYETIRNRNFLYRASSNSCLVEKDEEPPHPVNPDALKTTIAISKALHCKVLDYTSFMRKIVVDGSNTSGFQRTGIVGMDGYVKTSRGNVRISTITLEEDACRKLSEKEGVVEYSLDRLGIPLIEISTEPDIIDPDHALETAKAIGHYVMSMQNFRGEVDSIRQDVNFSMGFGRVEIKGVSKLSFIKDTIEYEIKRQSSLEAISRILAEKPHEIGNFIDITGMFTNTDSSMIKKSIASGKSVMCARVSACNGLMKHGNYKLGREFADVAKNMGLGGLMHSDEFPAYGLSDEELHSIYSTAGKGDNDAVVVVLGEKSRIEKLKPLLDERFDKILKMQLEETRSATPSGETRYLRPLAGKERMYPETDIPAVKITEAIMESIEKLVPKSLEETMNELTKKFKLSQVEAESLINNNLLSLFKALAGNFDNPHILSRILLQTIPELENKKGKKLSQVQMVDIFGNQYLEARQLPQYHNTDSILELSRREKWDRNTFETALSLYIIDNIPVSELEKREELKMLNDNEIKKILDELVKDGNVTQKNVIPLFRGKTKQSFNPSDVIKIFVTMQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N318</accession>
    <name>A0A1V0N318_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase 4 subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0579</name>
        <name evidence="4" type="ORF">HLB00_05355</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000178">
        <property type="protein sequence ID" value="NOL60261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141699.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N318"/>
    <dbReference type="STRING" id="74969.FAD_0579"/>
    <dbReference type="GeneID" id="31676083"/>
    <dbReference type="KEGG" id="fai:FAD_0579"/>
    <dbReference type="OrthoDB" id="371891at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050616">
        <property type="entry name" value="CPA3_Na-H_Antiporter_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005046">
        <property type="entry name" value="PRK06459.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43373">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43373:SF1">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="2">
        <location>
            <begin position="93"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="581" mass="64501" checksum="CE5747FA8AFAC28B" modified="2017-06-07" version="1">MILYYLPLILVFLSVLISIKYRTAGYLLTAIASAMFFLFTFRIYDYITYFYLIAAIVWIIASVFSISYSKKYGRWLAPLFILTIAGMMLILYSPNYLLFITGWEIMSIPAYVTVAVNKKNDMEAYIFMFFSEISTVLIITAAVISYVYTGTLDFSKLTNDTVLLIFAIGAMSKMGLTPFMISEWLPIAHGSAPANTSAIFSATMTLMGVYGIVKIALLSVVSIDIGIIFIIIGVISVLFGALYAYISENMKSLGGFSTIENNGALMATIGLFVAVDNSVLREFILISIAIFAMAHSIAKTGLFITVGHTGVEYFSAVNGEKSTINQIGKFFALSSLSGLFPSLGGLGTWMILESFFMGAYLYGPLGITSIIAGSLIAMGEGFATAAMLKVFYFTDNHKKTSGKNLENYTILATGLILVFLFAVSFLLIGNEYISGIPSVLVFKGLMIESRFGPADFGLITPLYIFIFLLLFSLIVYLVFGKPRVRVAKRWNGGIEHNEYFNSFNYSNNIRLILKRVLRTSYTSEDGVETVDIFWLVMINIAKSYRKFARLVAYKIMNSSISYYIIYMIIAFILVIIIASFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N342</accession>
    <name>A0A1V0N342_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0596</name>
        <name evidence="3" type="ORF">HLB00_10075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000443">
        <property type="protein sequence ID" value="NOL61164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887653.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N342"/>
    <dbReference type="STRING" id="74969.FAD_0596"/>
    <dbReference type="GeneID" id="16025803"/>
    <dbReference type="KEGG" id="fai:FAD_0596"/>
    <dbReference type="OrthoDB" id="56502at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012015">
        <property type="entry name" value="UCP_HTH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057055">
        <property type="entry name" value="wHTH-PRTase_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24409">
        <property type="entry name" value="wHTH-PRTase_assc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004955">
        <property type="entry name" value="HTH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRTase associated wHTH" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL61164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="256" mass="28880" checksum="F84230F668248259" modified="2017-06-07" version="1">MKIEQALISQLMILLNIKNGKTRPSEISRELDITIQGVVYHMKILKNKGFIDDENRITKEGFDFLYNGLNYMENFVHSSLISIDSSLVWEVISDENFEANQNVSLYMNAGYLHAGAYTGRGAHGVTVTRAVKGKCTGVTAVREIINIKKSRIVVLAVNNVEKVDNMVSISQLVKNTLESMDFDFLGIIGEMAKNITDLLNIRPQFEYATINSAFEAARRGFTTAIVVSERFFHFSLNEIRELQSKNPGIELDLRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N343</accession>
    <name>A0A1V0N343_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N343"/>
    <dbReference type="STRING" id="74969.FAD_0663"/>
    <dbReference type="KEGG" id="fai:FAD_0663"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="78" mass="9078" checksum="DFF4C2B37F1F4761" modified="2017-06-07" version="1">MIFRINVKNENSFLQVILYENGSKYLVFPKLILIHNFLAQSGSSTEKFLFIKVLHQFIDSFSCKYGSSKVEAHVRLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N372</accession>
    <name>A0A1V0N372_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine hydroxymethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N372"/>
    <dbReference type="STRING" id="74969.FAD_0643"/>
    <dbReference type="KEGG" id="fai:FAD_0643"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="387" mass="43183" checksum="416170004096C503" modified="2017-06-07" version="1">MIMETARIIDEYDKYRNSTLNLQASENVLSPDARKALSSDMASRYSLSIGDYNAYGGTVYFDRILDLLKDNTCRLFGSKYCDPRPLSGHVAAEMSLLSVLGTNKNVMAISEEDGGYPGYSGGHLDRVLGYKFYEAPYSNFDLEYDLVEEKIKANNIGTIILGQSMFIKPYDMKRISEICEKHGTKILYDASHVMGLLAGKAFQPDALKYSNIVYGSTHKTFFGPQGGIILTDEEDIYNQIEDNAIFNTMDNINLSRIASLSIAVEEMLKFGKVYAGSVVKNTANLSHSLIENGFGLLPGSENSETHQILIDPEYLKGKGFGYHSFSTQLEKNRIIIDRFGRIGTQEITRWGISDMESLSDIITGICNKLNRAVEINDMIGAKALKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3B4</accession>
    <name>A0A1V0N3B4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141888.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3B4"/>
    <dbReference type="STRING" id="74969.FAD_0738"/>
    <dbReference type="GeneID" id="31676241"/>
    <dbReference type="KEGG" id="fai:FAD_0738"/>
    <dbReference type="OrthoDB" id="39584at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01081">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="268" mass="30555" checksum="014F007605464E64" modified="2017-06-07" version="1">MIKLEYNGFHANFNPVGAYLEDLQKDGTSIIRKSSDKNSTHGGAAVLFPFGNRIQNAEYYFNNKQYSLPENDGKNSIHGLVRELAFDSNSGDKFIEFSSHFKSMFYPGEAYIKIKYEITGNLFVTSFYVKSLTSIIPVEIGFHPYFNVHGSYSISYNSRMKKFNYKDVYFPDGSTVDVDYNGKELNKIPLDNCFYLDSTVILKDEKHSIRMVRKNMPYLVLYNGQYAGNDSIAVEPMTGIPDVYHNHVGLVTLEKNAEFVCSYSIEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3C6</accession>
    <name>A0A1V0N3C6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pantothenate kinase</fullName>
            <ecNumber evidence="5">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_0692</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the prokaryotic pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3C6"/>
    <dbReference type="STRING" id="74969.FAD_0692"/>
    <dbReference type="KEGG" id="fai:FAD_0692"/>
    <dbReference type="OrthoDB" id="57436at2157"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02025">
        <property type="entry name" value="PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00215">
        <property type="entry name" value="Pantothen_kinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004566">
        <property type="entry name" value="PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00554">
        <property type="entry name" value="panK_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000545">
        <property type="entry name" value="Pantothenate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="14">
        <location>
            <begin position="96"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD84599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="320" mass="37464" checksum="387B3CBF1D1EE29B" modified="2017-06-07" version="1">MDMNKTYLPRRTISSNLYLSFSRDEWAKRRGNLNITLSESDIKGILALNDKITASEIQDFYFPITRLLQLSINNNINLYRERNDFMGIKPQKMPFIIGVTGSVAVGKSTTSRLLKTLLERINPDLRIYIVSTDNFLKSNARLMEENIMERKGFPESYETQDLINFLVDIKSGVARTQIPVYSHLKYDILPEKQDLVDPDILILEGLNILQVKNPGKKDEIYVSDFLDFSIFIDAKVEYIKEWFVERFFLLMETAFKDKDSYFKKYSELTKEEARELSSKIWDNINGKNYSENIVKTRYRAELIIEKGKTHNIEKVMMKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3D1</accession>
    <name>A0A1V0N3D1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="2">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="2">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">msrA</name>
        <name evidence="4" type="ORF">FAD_0744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141900.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3D1"/>
    <dbReference type="STRING" id="74969.FAD_0744"/>
    <dbReference type="GeneID" id="84217364"/>
    <dbReference type="KEGG" id="fai:FAD_0744"/>
    <dbReference type="OrthoDB" id="5961at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="178" mass="20307" checksum="06FB96627F32662C" modified="2017-06-07" version="1">MSEKVLVIGTGCFWCSEAIFKLIKGVNNVVPGYAGGHTENPTYREVCTDKTGHAEVVKVSYDPDIISLEKLLELFMATHDPTSLNKQGNDIGTQYRSIILYNDDAEGKVIKDFLKEHQKNYSKPIVTEVKKLDRFYEAEDYHHNYFANNQSNPYCAMVIKPEVNDFIMKHGNILKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3D3</accession>
    <name>A0A1V0N3D3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141926.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3D3"/>
    <dbReference type="STRING" id="74969.FAD_0758"/>
    <dbReference type="GeneID" id="84217378"/>
    <dbReference type="KEGG" id="fai:FAD_0758"/>
    <dbReference type="OrthoDB" id="385094at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="266" mass="30131" checksum="C24882D4F4023C51" modified="2017-06-07" version="1">MSQTNYKADYKKAYVNYRHVKLDLATKKEHIKIIARNGKDSFWNRQKTYLYALCVENGLCNGNLDFFTFENSIVPGCMNFKYKSGQLFMCNMDQNHNFLGTFGADEYSFLKVAGEIVLDIGSKVGDSPIYFTLNEAKNVISVPEDSFYEILMKNVKANDLEKRIVISNATYCGGKKDLSLKELAEKYGIDSGVLKVDGENSIKKLLAEDNESLKIFKRIQILYEGSYADIEKKLQEAGFKTHIEKRALQNLAGDTGFICAEYSNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3E0</accession>
    <name>A0A1V0N3E0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.35</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0754</name>
        <name evidence="6" type="ORF">HLB00_06830</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000242">
        <property type="protein sequence ID" value="NOL60545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141918.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3E0"/>
    <dbReference type="STRING" id="74969.FAD_0754"/>
    <dbReference type="GeneID" id="31676257"/>
    <dbReference type="KEGG" id="fai:FAD_0754"/>
    <dbReference type="OrthoDB" id="51300at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="188"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="289" mass="32343" checksum="3F84F83D324871D2" modified="2017-06-07" version="1">MAKKVAVIGSGIMGQGIAQVFMRNGMDTLLIDINDRILENAKNSIADGKFGLSRLVDRGTITEDQKAEYMKNLSVSTDYGMLNDREFAIEAVPEIMPLKLKVMESIEKNIPEKSVIASNTSGIMISEIGMNIKDKSRLIGMHWFNPAPVMKLIEVVKTRFTSDNTVNMILDMARSMGKEPVVVNDYPGFFTTNFVHSWLVESLRLYEKGIAGKEDIDKMVKLGFGFPMGPFELMDTIGLDTMKEIGDYLYSETGDMRMLPPPILKEMVYAGYKGSKKVKMDSKGGWYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3L7</accession>
    <name>A0A1V0N3L7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily multidrug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0803</name>
        <name evidence="10" type="ORF">HLB00_00265</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000009">
        <property type="protein sequence ID" value="NOL59272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887903.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3L7"/>
    <dbReference type="GeneID" id="16026023"/>
    <dbReference type="KEGG" id="fai:FAD_0803"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17329">
        <property type="entry name" value="MFS_MdtH_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517:SF14">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="404" mass="44588" checksum="008011CD9AE5E86E" modified="2017-06-07" version="1">MVSFSSDIRNRQVVIVSLSSMMRSLGMGASWPFMAIFLSLYIHLAVYIVGIIFTLLSLMSMVFSILGGYLADLKGRKFTLMLGSISGIFIYLSIALTFLFHIYTLTIILFIFSSFSGSLVYPSASALIADVTNPESREGGYSIYRILSNVGWAVGPLMGSFIYSTGIIYIFYALVVASILQTIIILFVKKQNVLKTGKGTRNPFLVYDKYLFIFSIATFFIILLSSQFSVSLPLYSEIAIKINVADLGYIYAINGLVVVIGQYPLIQLFARFGDLITFIAGALFYALGYFIIAFSTNLYGLMFDMVIITMGENLTTPTINTVISKMSPPGKTGRYMGFNSMVNSIGRAFGPSMGTYIMYTFHYNGLATWSLIAIFGVFSAIVIVIFAISYNKSGNTYIARGTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3M5</accession>
    <name>A0A1V0N3M5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Asparagine synthetase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">asnA</name>
        <name evidence="7" type="ORF">FAD_0792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887893.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3M5"/>
    <dbReference type="STRING" id="74969.FAD_0792"/>
    <dbReference type="GeneID" id="16026011"/>
    <dbReference type="KEGG" id="fai:FAD_0792"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005054">
        <property type="entry name" value="PRK06462.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF48">
        <property type="entry name" value="ASPARAGINYL-TRNA SYNTHETASE-RELATED PROTEIN (N-TRUNCATION)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="100"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="319" mass="37423" checksum="F6AF8CB76979EA55" modified="2017-06-07" version="1">METINKNEEYVKEEITRSMQHLSDKRVQHAIKVQSYIRSYVTDFLREAGYIEIAPIIISPLTDPLNHPVYDPKIHAYGGDMWITQSMIFHKQIAVQELKKIFIMSPNVRLETEEKSKSGRHLYEFTQIDVEALEKSREEMMSLAEDMIIYTISRLKKEHKEELEYFHRTLPDYAKPFPVITFEEAEKKYGKGFETPLSKESSTPVWVVDIPLKEREFYDREYPEKPGILRDMDLIWPEGFEEASSGGEREYELSQILDRIQKKGQTEEQFKWFIELAKQGIKYTAGFGIGIERFTRFVCGVEKIEDVTTFPKVPGRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3S1</accession>
    <name>A0A1V0N3S1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily multidrug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142048.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3S1"/>
    <dbReference type="STRING" id="74969.FAD_0839"/>
    <dbReference type="GeneID" id="31676339"/>
    <dbReference type="KEGG" id="fai:FAD_0839"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17321">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000503">
        <property type="entry name" value="Drug resistance transporter, EmrB/QacA subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="7"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="474" mass="50379" checksum="2EE0746DAD1955E2" modified="2017-06-07" version="1">MDASFKLIISLLLAVLMGAVDSTIVLLALPTITDSLKTQLSLSIWIILIYLLVIAVGTTQLGRLGDILARKNIFISGIAIFTIGSALCGASADIIELISFRVIQGIGTAMVQSNSGAIIADNFLPNKRGRVYGYTAVGYNAGAMLGIVLGGVITTFIGWRYIFYINVPIGIFAIYYAIKFINRSTPVRNKLDLPGMSTLGAALISISYAGVNISTSGITTFNLALMGFGALLILLFIYIETKVAKPLLPLKVFRIKILSYSLFASFFQSLGFLAVVFIIIMYLQGVRGLSPFDSALLLLPGYVIGSMLGPYFGRLADRIGSRIPATVGLLMMAGAIIVYSLITVNSTLYIVLIASGISGTGSSMFFPANNSAVMANSPKELYGMSSGFLRTLANIGMLGSFVISVSIASLGVPRSVAFEVFAGVGKLVGGVSTSFMSGIHYSLYVSMAILLLGAFLSFSRGKEERRSSDITVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3V7</accession>
    <name>A0A1V0N3V7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142234.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3V7"/>
    <dbReference type="STRING" id="74969.FAD_0957"/>
    <dbReference type="GeneID" id="31676458"/>
    <dbReference type="KEGG" id="fai:FAD_0957"/>
    <dbReference type="OrthoDB" id="132045at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="320"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="476" mass="56091" checksum="E1A5CB2AD20E4601" modified="2017-06-07" version="1">MSQQKFIDRKEELEMLGYDYSRDGSALFIIYGRRRVGKTELINQFIGKNGIYFLSTDEGDIQNIKDFQKVISNFLNDESINNGVYKDFYSFFYMLINNISFKDYVSNKKLIIGIDEFPYLIEGNKSIPSVFQKIYDLLLKDMNIMLILSGSSITMMENNVLSYKSPLYGRRSGQIKLKPLKFRYVKEFINYNFTDLCKIYFILGGIPEYLLKMDNKLTFDENILHNIINKNSTLYNEAEFLLRTELRETRNYMLILRSIAGGYRTVGEINSYTNMDKSMVSKYIDILLSLELISYEIPFGETEKFRKRLYYINDNYLKFWFRYILPNRTGIENSNYSEVARKIENDFSQFGGEQFEYLMRELIMDGILGRTFTTVSRWWGKVGNNTGKNVEEIDIVAYSDTRNEILFAECKWTNKKVSYKIIEELIRKSKWLLNKYNNSKVTYAVFSKSGFDFNSDILEKNIIAMDLNGIENALYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3X2</accession>
    <name>A0A1V0N3X2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142135.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3X2"/>
    <dbReference type="STRING" id="74969.FAD_0892"/>
    <dbReference type="GeneID" id="31676396"/>
    <dbReference type="KEGG" id="fai:FAD_0892"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="135" mass="15274" checksum="1F03A49681BB61CC" modified="2017-06-07" version="1">MKRLNLSIKKYESSLLTIPEIDLDVEYKIASADVVLIGEGLNLSKLFLSIINTKSKRDKPYNGIISNSIKNEDYKSSKFTFNKPAFALFKDDTNLEIEVYAEPVYVRFSDKHLNSFGVPLFNITGIGGVKFTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N432</accession>
    <name>A0A1V0N432_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951127.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N432"/>
    <dbReference type="STRING" id="74969.FAD_0963"/>
    <dbReference type="GeneID" id="42785075"/>
    <dbReference type="KEGG" id="fai:FAD_0963"/>
    <dbReference type="OrthoDB" id="350054at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="97" mass="11733" checksum="515F74A07CF922A4" modified="2017-06-07" version="1">MLTGLSYEPFYYGLESALSLLNLWEQETNPVIITPLHIRTGMMQYEGRNYIVRRISREMFFGYQYLKYYDFYIPVSCLEKTLIDLVYYNEKLPEYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N433</accession>
    <name>A0A1V0N433_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142281.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N433"/>
    <dbReference type="GeneID" id="31676482"/>
    <dbReference type="KEGG" id="fai:FAD_0983"/>
    <dbReference type="OrthoDB" id="57413at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="109" mass="12143" checksum="6F59403685270C85" modified="2017-06-07" version="1">MVGFYLSQIANPVHSEILILHVSLGILLFIMSILSYMYTKNITRLAHLAIVNILLIVITGIIGSGFIILKTNSFYSTYIPYLHMLLAIGIISNYAVMLGIKRTINSVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N440</accession>
    <name>A0A1V0N440_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N440"/>
    <dbReference type="KEGG" id="fai:FAD_0965"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="54" mass="6797" checksum="C6B1CFB731536E43" modified="2017-06-07" version="1">MKYINEFFENFKDKYIFSANDVKRFLSYRKANDDYYKIFLYNLTKDCVHNFVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N475</accession>
    <name>A0A1V0N475_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetoacetyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142428.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N475"/>
    <dbReference type="STRING" id="74969.FAD_1061"/>
    <dbReference type="GeneID" id="84217660"/>
    <dbReference type="KEGG" id="fai:FAD_1061"/>
    <dbReference type="OrthoDB" id="371752at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="98"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="530"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="646" mass="72271" checksum="6CA94A39223868BA" modified="2017-06-07" version="1">MDTGAKKLWEPVNEYKEKSTMNQFLNYVNTNNHTNINSYKELWEWSVKNPEIFWGALADFSGLNLGEYSSILSGNNVNARWFEGAMVNYADRVYRMRDMEKAAIISYNEEGKEQVITYHGLWQKVSSLAAYFQNNGIAAGDTVCAYIGNIPEAVIAFLATASIGAIWSSCSPDFGIKGVIERFSQISPKVLVVSPEYSYNGKLYDRTENAIKILKSLPEVRIAITTGNKEIHNFTKMISIPDSNGDFMPVKVEFSHPLWILYSSGTTGKPKAIVHGHGGILLEHLKVIMLHMNIRENSVFTWATTTGWMMWNVLVSGLLAGSTIFLYDGSLSYPDTGILWKLSEKYGITHLGVSAAYIGALMDSGIKIKDQYQLDKLEFIGSTGSPLSPAAFEFVYKHIKGNVWLSSLSGGTDLCSAICLGSPTLPVYSGMLQCRGLGAHVEALDPDGKPVVNEKGELAIMDPMPDMPVFFWNDPDKTRYYESYYDYYPGIWRHGDYISIDDEGRVIIYGRSDAILNRNGIRIGTGEIYSSLNGIEMVDDSIVIGYTDSRKIYRIALFVVLKGNTELDDNLVRAIKSKIRDDLSPRHVPDYIFQAPSVPYTLNGKKMEVPVRRILEGELPEHILNRDSVKNPDSLDYYVAIGKTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N493</accession>
    <name>A0A1V0N493_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RecA-superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N493"/>
    <dbReference type="STRING" id="74969.FAD_1077"/>
    <dbReference type="KEGG" id="fai:FAD_1077"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051347">
        <property type="entry name" value="Circadian_clock_KaiC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42926">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42926:SF1">
        <property type="entry name" value="CIRCADIAN CLOCK OSCILLATOR PROTEIN KAIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="88"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="351" mass="38669" checksum="5475FDB70EE336F4" modified="2017-06-07" version="1">MAVQGASGLSYKFDYIIASGEDKIAVKLANSDITTNDIMVFNSQATDAGIARKILISEIELGEYVKKMCNIYGIIISDPREIATPDAFRARFGIPILDAKLSGGLRPGYVYMISGKPGVGKTTLSSTFLSYGASIGEKGLMILTDTFPDQFIDNIRTMNIGFAEAYKDRKIEVMEISDQIRSMKSDISQGKADSRKFITKLVTELKKIIISKDIKRVVIDPITLLIIPDDDFVNLLLNSMAIKGVTILITSGLRNSNLSIFGIEEYYTTGIIKLEYRPQNDISTRTGSIIKMRGTAFDPNPFDFKITADGIVPLSNLKMPEPEATKSNREAIEGNSPENPSSDDSLFRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4C4</accession>
    <name>A0A1V0N4C4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homogentisate 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142423.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4C4"/>
    <dbReference type="STRING" id="74969.FAD_1058"/>
    <dbReference type="GeneID" id="31676557"/>
    <dbReference type="KEGG" id="fai:FAD_1058"/>
    <dbReference type="OrthoDB" id="57114at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="382" mass="44323" checksum="57A9E967E5288C71" modified="2017-06-07" version="1">MVYYVKKGKVPEQRHTYDDRSHIFKEELFGLKAFDGKYSLLYHKYDPAEIEKTSVEYREKLSSVDLVEHRHIKTGMLGKLNNFYTGRQTLFYNDSTSTGIIDTDTSPDTYFRNALCDEVFYVQSGKGSIESPFGTLKFRKGDFIYIPRGTTYRAVMDERSFFFFTISSDHMDIPAHYMNKYGQIKEGMPYYTRDIEIPEFHESTESPGEYHIMVDYGSYYLNITRTYPVLDLEGYDGYLYPFTINIDKFAPIVGKLHMPPPVHTVFEADHFMIGAFLPRLFDFHERAIPIPYYHNNIDSDELIFYSSGNFMSRKGIGEKSITMHVHGIIHGPQPGVVENSLGATKTDEVAIMVESYKWLMPTEKAESVKDKNYMYSWKAGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4E9</accession>
    <name>A0A1V0N4E9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartokinase (AkH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1132</name>
        <name evidence="4" type="ORF">HLB00_00300</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000010">
        <property type="protein sequence ID" value="NOL59279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142511.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4E9"/>
    <dbReference type="STRING" id="74969.FAD_1132"/>
    <dbReference type="GeneID" id="31676629"/>
    <dbReference type="KEGG" id="fai:FAD_1132"/>
    <dbReference type="OrthoDB" id="8904at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04234">
        <property type="entry name" value="AAK_AK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="entry name" value="Aspartokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF70">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="348" mass="38994" checksum="FD47C7B5DACB41BD" modified="2017-06-07" version="1">MQVVKIGGSILKNKEDLNLIKQKLIDCHNCIIVTSALKNVTNMLIEAYETKNTGIIDSIYHMHTDMIQLDSNIISTLAGIREELKKLVVQENSPSLRDHIISYGERMSTLLLYNFFKDNGVNASYIIEPLLVTDNNYGDSSCLMDETARKIENCVFGDFTIVPGFYGTTIEGNITTVGRGGSDYTAMVLASILNCDVRIITDVPGIMTSDPKLFKNSRTLAEVSLSEVLKMSYFGVKNFNYKTFMPVLGTDINITVESLYVDSVTRITKKPVNSIKCVAMTNYGRKDRKNMLVFIGHGLSDPSISRDIISKIGKDHLYHMDSLSLSILVDEDLIKHSNYFEEAPLWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4F0</accession>
    <name>A0A1V0N4F0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1097</name>
        <name evidence="3" type="ORF">HLB00_00890</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000025">
        <property type="protein sequence ID" value="NOL59395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841327.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4F0"/>
    <dbReference type="GeneID" id="16024326"/>
    <dbReference type="GeneID" id="31676595"/>
    <dbReference type="KEGG" id="fai:FAD_1097"/>
    <dbReference type="OrthoDB" id="387667at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="727"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="81838" checksum="9A7EBCAEF59F5DC1" modified="2017-06-07" version="1">MGKLTAIIVGYIATTFAAYIILSVSYNPLVNWLGPYFGYRFPFILGIIYLIVGSPLHNTIILEVWIIIGLLVGISTRKGLRAWGSASLVWTLTTITMALSAIAMLGISLGNITSVSIISGTVSQLLDVLLAATAFVPYSTNIATIATEPVLRVLIPYLSSSITSGTTGTAGLSGAITELSIHALENYIIFVATSIISGAVIHRVLHGKKKISRKAVAAAISIFIAIIFIAMAASAGISSSSQPALQTGETGNHEIPAVGLNTLFPLSISGNSARIAENNTVMPSYATGNNSSDQAALSLITPQGNLYNLFAMDSSSNNSNSIWSGNGLMLGDFIVSANMTSLIGSELGAEYSKLASFAPQNALILAYNGTGHSGSASSMASSIGKEIGTTFNPVVALKNITLSGNNVEIFIYSSSASIHKLDSDFMATFGNGYNGSVPEIFVTDQGLNNYNSYILSSGYINASIVKSLAGNTGINLSNELFTAGLFEYTNHFHSSGDVHSYNLSELMQYSSNISFSNSSQLSLVGIGYNNGTGSVVDTSNYTFDIYSNNASLAAQTALNTPGSTFHNSNYRAFSPSSVSVKFNAVFPAYILYDTTVKRVSANTVEINVHIKNNDTSQLKDFYASQSAFVNNYVKYGAASSVSGNYNESNITLSPGHYANFTYKISFTGIGTYVIPYTNISYNLQGKAFSYGTNATYISQEKPGYITAMNSMINNEASQYTFLGKTIIAVQGFAISLIDIILFAIVALDVVIEVKGLRKLIREHNQNTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4F1</accession>
    <name>A0A1V0N4F1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe-S cluster assembly ATPase SufC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sufC</name>
        <name evidence="4" type="ORF">FAD_1089</name>
        <name evidence="5" type="ORF">HLB00_00855</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000025">
        <property type="protein sequence ID" value="NOL59388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074108.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4F1"/>
    <dbReference type="STRING" id="74969.FAD_1089"/>
    <dbReference type="GeneID" id="16024319"/>
    <dbReference type="GeneID" id="31676588"/>
    <dbReference type="KEGG" id="fai:FAD_1089"/>
    <dbReference type="OrthoDB" id="18492at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204:SF1">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="244" mass="27375" checksum="8C86D172F83B3A2E" modified="2017-06-07" version="1">MALKIENLKAEVEGKEILKGIDLTINSGEIHALMGPNGAGKSTLGEVLIGHPNYKITGGKILINGRDLTNATPEERARAGLFLAFQNPISISGVKISTFLRMAYNNLYPDEKMPLKEFFNMVKTVMKDVDMDESFISRSINDGFSGGERKRFEVLQMVILKPKIVILDEIDSGLDVDALKLVSAEIKKMHDQKVGFLIITHYQRILKDIIPEFVHVLKDGRIVMNGDNKVSDRIEDEGYDWIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4H1</accession>
    <name>A0A1V0N4H1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1113</name>
        <name evidence="7" type="ORF">HLB00_00395</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000011">
        <property type="protein sequence ID" value="NOL59298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886218.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4H1"/>
    <dbReference type="STRING" id="74969.FAD_1113"/>
    <dbReference type="GeneID" id="16024343"/>
    <dbReference type="KEGG" id="fai:FAD_1113"/>
    <dbReference type="OrthoDB" id="57577at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF106">
        <property type="entry name" value="LIPID KINASE YEGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="297" mass="32774" checksum="E84F38FFB2E2EC89" modified="2017-06-07" version="1">MKIHILANEHAGSGNALKIMEEIKSILNRYELTSSFTEKDPANFIQFMDENPDIKYLIAIDGDGTVNYAIQALAGKDTILIPVPAGTGSDLTRTIGRVTVKEIPEIISGGRFRKVDLGLVHINGKSRYFMNIMETGLGGNVMVRVNSTEHRTGSTFVKAILYYILTMKSIGADIKIGDEIIHEQIIDIIIANGQYFGKGMHASPDSKIDDGFLDLHLIKYMPRSRILFKLPSLRSGAYISDKYVINKKIKEASVNCKSIVEIDGEIIIADSFSVEVLPGIINIFELPGEDNSAINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4H3</accession>
    <name>A0A1V0N4H3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IS605 OrfB family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4H3"/>
    <dbReference type="STRING" id="74969.FAD_1166"/>
    <dbReference type="KEGG" id="fai:FAD_1166"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010094">
        <property type="entry name" value="Transposase_put_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01765">
        <property type="entry name" value="tspaseT_teng_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="5">
        <location>
            <begin position="157"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="6">
        <location>
            <begin position="280"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="374" mass="42711" checksum="1C6E210DA3F32390" modified="2017-06-07" version="1">MNNVLKTLQIKLLPEDNQKDILLNTFKKFNEACNFVSKIAWDNKIYNKISLQKLVYYDIRNKFGLSAQLTIRVIAKVVDTYMVDRSIFHEFREYGSIVYDQRIMSFKGMDEVSLNTIKGRIKIPITIGKYADIPFDMVRGQCDLVRKHKIFYLMVSVDIKEEPVIEPKNVIGVDMGIANISVDSTGKYYSGDEIKNVREHNLDLRSRLQSVNTRSAKRHLKKLSGKEHRFATNTNHIISKEIVNKAKGTSSAIAIEDLTGIKMRTTVKKGNRYIHNSWAFYQLRLFIEYKAIEAGIPVIVIDPHNTSRECPNCHTISKKNRPERSIFKCISCGLKGEADYIASLNIRNRAVANQPIVAGDFFVHCDTLVASSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4I0</accession>
    <name>A0A1V0N4I0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(S)-2-hydroxy-acid oxidase chain D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142507.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4I0"/>
    <dbReference type="STRING" id="74969.FAD_1130"/>
    <dbReference type="GeneID" id="31676627"/>
    <dbReference type="KEGG" id="fai:FAD_1130"/>
    <dbReference type="OrthoDB" id="26910at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051914">
        <property type="entry name" value="FAD-linked_OxidoTrans_Type4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42934">
        <property type="entry name" value="GLYCOLATE OXIDASE SUBUNIT GLCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42934:SF1">
        <property type="entry name" value="GLYCOLATE OXIDASE SUBUNIT GLCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="470" mass="51588" checksum="B2757CC0FDF52D19" modified="2017-06-07" version="1">MQISGKSVIQELIDKLGKDIVLTTKEELIPYMKDASYIKGKMPLAVCLPENAGQISSILKICNKYKVNVTARSGGTSLTGSSVESFDGIIISTMNLNRILELDLSSRYVVCEPGVRIDILNMELKKHNFFYPPDPASSRASTIGGSLSTNAGGLRAVRYGATKEWVLGMEVVLPTGEIIRTGEYTLKRSAGYDLTALMIGSEGTLGIVTKAVLKIEPLPEATAKIIGFYRDILSVGKSMDTIKSQGITPIIAEFMDLPTINSIKKAMGIEVPAYAQYLLMVDIDSPPEALERKLASAKDIMGKFSEDVIVIRDQKRMDEIYAARKGAYSALLEQRDNSNQLIVIGDVIVPSSQLADALGEIEGFARTDGLKTTLFGHIGDGNIHANIFMDNTEEGRKKMAKLQMDIAGVAIRHNGSVSAEHGIGTEKNELLYEEYKQRNSLYTLEVMRMIKKAFDPNNILNRGKIFYEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4K6</accession>
    <name>A0A1V0N4K6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Citrate synthase</fullName>
            <ecNumber evidence="6">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 8">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142554.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4K6"/>
    <dbReference type="STRING" id="74969.FAD_1165"/>
    <dbReference type="GeneID" id="31676663"/>
    <dbReference type="KEGG" id="fai:FAD_1165"/>
    <dbReference type="OrthoDB" id="21302at2157"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06118">
        <property type="entry name" value="citrate_synt_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054926">
        <property type="entry name" value="Cit_synThplmales"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041157">
        <property type="entry name" value="Cit_synThplmales"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010640">
        <property type="entry name" value="PRK14037.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF4">
        <property type="entry name" value="CITRATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="374" mass="42350" checksum="A554D0A72EA2DA11" modified="2017-06-07" version="1">MAVSLGLEDVFIKYTGLTFIDGNAGVLRYRGYDINDLVQNTGFEEVCYLMTNGELPNSQQLAEFKKSVKEHYKLPDHVMELISDLPREADTLTMMETAFASLSSGDYQWNKENDRKQVPKILGENLGIISNIYRHKMGMGLQNPDPKYDYAEAFLRNCFGNADEKKISAMNAALVIYVDHEVPASTTAALVASSTLSDMYSCITAATAALKGPLHGGAAEAAYKQLLDIGNVDNVENWFKTNILDGKRRLMGFGHRVYRTYDPRMKIFKKLATTLEQTDEQKKLFEIAVKLEELGVKEFGGKGIYPNTDYYSGIVFNEIGFPIYMFTTLFGFSRVLGWLSHITEYVEEEERLIRPRAVYTGPDKRDFVKMQDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4K7</accession>
    <name>A0A1V0N4K7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142547.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4K7"/>
    <dbReference type="STRING" id="74969.FAD_1159"/>
    <dbReference type="GeneID" id="31676657"/>
    <dbReference type="KEGG" id="fai:FAD_1159"/>
    <dbReference type="OrthoDB" id="197151at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF6">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="42"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="262" mass="30041" checksum="B969A46E05906B2C" modified="2017-06-07" version="1">MEEIYFLNDGTYELDSGAYFGIVPKVLWSKYISDNNNKIRITTNIPFLRVNDKNILVDAGIGNNFSDRFRRIFVPEKNNDIADSLENDYHIKGVDNIILSHMHFDHNGHIFSGNKLFRNSQIIMQEKELKAFRHPNDFTRGSYIPGKIHGKIKTIDGSRKITGNITAINTGGHTEGHMVIFFEINSKKYMYGGDLFPSSFHLKPYYITAIDSYPIETLKMKKKLLKKAINENISIIFNHDNKNIMGKVYGSAEKPEIEFGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4L3</accession>
    <name>A0A1V0N4L3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">tRNA carboxymethyluridine synthase</fullName>
            <ecNumber evidence="13">2.3.1.311</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FAD_1172</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.311" evidence="13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886275.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4L3"/>
    <dbReference type="STRING" id="74969.FAD_1172"/>
    <dbReference type="GeneID" id="16024400"/>
    <dbReference type="KEGG" id="fai:FAD_1172"/>
    <dbReference type="OrthoDB" id="49957at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF7">
        <property type="entry name" value="TRNA URIDINE(34) ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="16">
        <location>
            <begin position="65"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ARD85047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="515" mass="59255" checksum="1F823DF9E55EDAF2" modified="2017-06-07" version="1">MDFYDQITSLIVNGKIKDKDQLQREKLLLSKKFNLDVVPSDVEILNYGDNRRFVQLLRKKPTRTVSGVAVVAAMTSPEACPHGKCIFCPGGIDSNSPQSYTGYEPSALRGRTNYYDSYNIAFSRLKQLETIGHDTSKVDLIVMGGTFTARSREYQEEFVKGCIDGMNRKISPTLDQAILENEFSQRRCVGMTIETKPDWFNEREIDEALSYGTTKVELGIQVLNDRILRLNRRGHGVEEIVRSTQLARDAGLKVLYHLMPGMYGSSYKEDIKSFDMVMGDERFRPDMLKIYPTLVVKNTALYKYWKEGKYIPYDTEKVVRMVTYFMKNMPPWVRVMRMQRDIPVNFIEAGVKRSDLHNLVDLEMEEMGIKTMEIRSREVGIMKDSFGNDYTLTRRNYRASGGDEIFLSFESSNGDIIGYLRLRIPSEMAHRKEVLSSSVIREIKVMGNIVPIGEESGENWQHHGFGKKLLDEAERISLEEYGKKRIIVISGIGVRNYFRKYGYERLGPYMAKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4M4</accession>
    <name>A0A1V0N4M4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142625.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4M4"/>
    <dbReference type="STRING" id="74969.FAD_1218"/>
    <dbReference type="GeneID" id="31676716"/>
    <dbReference type="KEGG" id="fai:FAD_1218"/>
    <dbReference type="OrthoDB" id="56872at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="386" mass="44192" checksum="EA86EC04EF6BE7A1" modified="2017-06-07" version="1">MRLYNFLAKLVNSESYYKLIDSEINEIVKLIRAGYQPEYIKKIHKNNFNFLFEFAKSRIKIAGKFSLHDHLFMDYYSSMYSTPEIVGKYRAKKLAGNKIVDAGSGAGMQDIMFSEFSDVTGVEIDSNRYAMANLNKIPYSSNVDFINSDIFSFNGDFSGNILFSDPLRPVNSGEKLFSQLVPDPVEIIHKKPELSGYAIDLPPHMEWDNIPLKGEKEYISIKGALNRLTLYSPSISEKISTAVILPENTVITGKPCTFKANIEYGRSTGQYLYVPDISITYAKLLNMVVKPEWVPVYIDERRQIFSGNSYESAFPGKQYSVISYSDNMNIVPLLRNVDAGKVFFRFKMKPEETYHYKNSIEKELAGSKNVYIFRNNDRYIIAEEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Q6</accession>
    <name>A0A1V0N4Q6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1254</name>
        <name evidence="2" type="ORF">HLB00_03000</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000097">
        <property type="protein sequence ID" value="NOL59803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142678.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Q6"/>
    <dbReference type="STRING" id="74969.FAD_1254"/>
    <dbReference type="GeneID" id="84217849"/>
    <dbReference type="KEGG" id="fai:FAD_1254"/>
    <dbReference type="OrthoDB" id="55709at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="77" mass="8841" checksum="F00DBBAFDF54E7C7" modified="2017-06-07" version="1">MADGSIEQECVFNRAGKCYFLESSITACSLCFNFKTFNMLGKKRKIYYNLFDYLKEANLSEGLFPSNDSEQDSLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4R0</accession>
    <name>A0A1V0N4R0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1242</name>
        <name evidence="8" type="ORF">HLB00_06095</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000206">
        <property type="protein sequence ID" value="NOL60403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142658.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4R0"/>
    <dbReference type="STRING" id="74969.FAD_1242"/>
    <dbReference type="GeneID" id="84217838"/>
    <dbReference type="KEGG" id="fai:FAD_1242"/>
    <dbReference type="OrthoDB" id="25212at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004983">
        <property type="entry name" value="PRK06366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="6">
        <location>
            <begin position="264"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="387" mass="41541" checksum="52453E0A4D910BA0" modified="2017-06-07" version="1">MKDVYIVSAKRTPIGKFGKSLAKIKATELGAAAIKGVIQDSGIDKDLIEEVIMGNVIQANVGQNPAGQAAFSAGLKPEVTKNTVNVVCASGMLATENAAREIMLEEHDIIVSGGFENMSNSPLIMPSEFRWGPKQLLYKNLKIEDSMLVDGLVDAMYGEHMGVSAERSAKKYGITRDQTDGFSVESQNRAIRATESGEFAKEIVKLDNLQKDEGMRKTSMEDLAKLNPAFDRNGILTAGSSSQLSDGASALILASEKALNEYGLKPIAKITGFSSASLDTRDFVEAPIPATRKLLEKQHKKIDYYDLVEHNEAFSVASIIVRDQLGVDPERFNVNGGAIAIGHPLGNSGSRIIVTLINALQSRHMKTGLATICHGGGGGHTLTLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4R1</accession>
    <name>A0A1V0N4R1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF211 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1262</name>
        <name evidence="2" type="ORF">HLB00_02955</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000096">
        <property type="protein sequence ID" value="NOL59794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886365.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4R1"/>
    <dbReference type="STRING" id="74969.FAD_1262"/>
    <dbReference type="GeneID" id="16024490"/>
    <dbReference type="KEGG" id="fai:FAD_1262"/>
    <dbReference type="OrthoDB" id="201945at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1340">
        <property type="entry name" value="MTH889-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003831">
        <property type="entry name" value="DUF211"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023129">
        <property type="entry name" value="MTH889-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42240">
        <property type="entry name" value="DUF211 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42240:SF1">
        <property type="entry name" value="DUF211 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02680">
        <property type="entry name" value="DUF211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160363">
        <property type="entry name" value="MTH889-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="88" mass="9686" checksum="CC203FF7382E5F01" modified="2017-06-07" version="1">MNLRRILLDVDKGLNRPTLTELAGSIEDVPGVDAVKITVTEMDMETMGTSITVEGININYNYLIKVIEDMGCAIHSIDEVITGKHIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4T8</accession>
    <name>A0A1V0N4T8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal peptidase I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142665.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4T8"/>
    <dbReference type="STRING" id="74969.FAD_1247"/>
    <dbReference type="GeneID" id="31676745"/>
    <dbReference type="KEGG" id="fai:FAD_1247"/>
    <dbReference type="OrthoDB" id="4822at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38765" checksum="4D4765570EF37DEB" modified="2017-06-07" version="1">MSIITIPVIVDSILDGYFNYTLPSTLLEISGVIIGSAATFILLIFIVKSIKLKNNFTNSNTYMKFVISGLVMSLFSFLFAWSMETKLIYMKNISIERLKVAYFIDFYMLAVDAIIIFKLLKNYFMSVVEYFSLYFYISLFLFGFITADIINLNNYYLIIFGAISIYFLLNSIFTSFHCKLNWFKINGNEFALMGVRGISMNPEFKAGDSVIIKRIKALDELKVGDIITYKSSNINSPLNASGYITHRIYEISGDIIRTKGDNNIVVDYMKIRLDDIVGIAVAKVVHINRRATGIEMIGDNRNKEDLPFFTPFNISARKSSLYFNIYFIIISLILIIIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4U6</accession>
    <name>A0A1V0N4U6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase, E1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4U6"/>
    <dbReference type="STRING" id="74969.FAD_1290"/>
    <dbReference type="KEGG" id="fai:FAD_1290"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43257">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43257:SF2">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="4">
        <location>
            <begin position="329"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="659" mass="71593" checksum="9427537738A8A387" modified="2017-06-07" version="1">MIKIRKYEEKLRDIYLSDKKPLFNIAAGKIPGEMHLSAGQEPSAAWMSVLLRNDDFVYSTHRPHHTAIAKGVDLNRMTAEIMGKHGGLSKGKGGHMHIFDKKVNFACAGIVGSSFPPALGAALASKLDGKDSIAVAFGGDGSLNQGMFLESLNLASLWKLPVIFVIENNDWAISVETKDSTPIKNDAIRADGFGMPGVYIENNDPVKMYKAAEKAVKRARSGEGPTLIAIDTYRYYGHFEGDPEVYRPKNQVKELLAKDPIKIMESDLLKKGIISKDEDDRINNSAMEEISQAFAFAEDSPLPVGSDSMDDVYAPVDYSIEPTTKGRKLPVYMAISEAISQEMEGNKDVLYMGEDVGKYGGIFGATTGLFKKFGAERIRDTPISESAFIGSAAGLAAAGKRPIVELMFSDFVGVTLDPIMNQIAKNHYMSGGTVNMPVVITTAVGGGYGDAAQHSQTLYSLFGHLPGLKVVVPSNSYDAKGLMVSAIKDNNPVVYMFHKGLLGLPWMPYPQSTVTEVPEEEYTVPIGKARIAREGKDITIIGIGATVHMAMEAAMELEENGINAEVIDLRSIKPLDTDTVIRSVGKTGSLLVADEDYAAFGLASEITSAVSHALFGKLDKAPESIVSPDVPVPYSQPMEKYWLPDTQKIVNRVMEMFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4U8</accession>
    <name>A0A1V0N4U8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-hydroxybutyryl-CoA dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4U8"/>
    <dbReference type="STRING" id="74969.FAD_1294"/>
    <dbReference type="KEGG" id="fai:FAD_1294"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3140.10">
        <property type="entry name" value="4-hydroxybutyryl-coa dehydratase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024674">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117:SF3">
        <property type="entry name" value="4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11794">
        <property type="entry name" value="HpaB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000331">
        <property type="entry name" value="HpaA_HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB/PvcC/4-BUDH N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="HpaB/PvcC/4-BUDH C-terminal" evidence="4">
        <location>
            <begin position="278"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54186" checksum="8A3C3A6824AD0B31" modified="2017-06-07" version="1">MSVESYKNSLNDGRAVYYRGKSVENVAAHPALGVPVSHASGIYRLQQDSKYENIMCFTDKKSGKASIFYKIPQNTEDLVVRHKLIYETTRLGRGQFNIVKAIGSDALFALMYVSRRIDSKYKTDYYNRVMAFYRYVVEKDLSLSLAQTDMKGNRSLRPSEQEDPDMYVHIVKRDKNGIYVSGAKAHTTQSIASNEIVVIPTRNMTEADKDYAVAFAVPANTKGITMIARPLKETETTMDDSLSVIGRENIEVETITIFDNVFIPMERVFLNGEYDFAGLLAMMFPTFHRFTAISYRAAMADFLIGTGKLLASYNGVDDKSNIRRNLAVLISYKETLKATAIASSYSCTYDKQASLAIPDIIFTNVGKLFANENYTDVVKNIVDIAGGLVATMPSYEDFENSNEKSSLMKYLAGRKKEETMERVRLFQTLREFISSLGSLYLAGMIHAEGSIEASTMELCRSYDYSSSIDLAKFASGINDKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4X3</accession>
    <name>A0A1V0N4X3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1289</name>
        <name evidence="2" type="ORF">HLB00_03315</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000103">
        <property type="protein sequence ID" value="NOL59863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886393.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4X3"/>
    <dbReference type="STRING" id="74969.FAD_1289"/>
    <dbReference type="GeneID" id="16024517"/>
    <dbReference type="GeneID" id="31676787"/>
    <dbReference type="KEGG" id="fai:FAD_1289"/>
    <dbReference type="OrthoDB" id="7914at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07812">
        <property type="entry name" value="SRPBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="132" mass="15627" checksum="5DEE86965B298FB0" modified="2017-06-07" version="1">MEFKKEIEVNSDREDIWELIKDYKRIPEFWHGTRSIEKEGNYYMVQFAFPGKGKMQLKEDEDNFILSENYLKGPFTGEKTTQLYGNDPVKIVSVWNIKLSPMLRAFSNKLQGHFEQGTEDALKRIKDYFESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4X7</accession>
    <name>A0A1V0N4X7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1304</name>
        <name evidence="3" type="ORF">HLB00_02410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000073">
        <property type="protein sequence ID" value="NOL59686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142783.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4X7"/>
    <dbReference type="GeneID" id="31676802"/>
    <dbReference type="KEGG" id="fai:FAD_1304"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="110" mass="11898" checksum="2372286114F9EB0C" modified="2017-06-07" version="1">MSAIDIAWMVGGIGVLFLTFLLIEIESDGIQSKLRAAAGFGFIIGIVYILAMDVMFVPGNKQYAQIHGIAYTPMPFVESTLPGIILIVIAIICVILSFDKIRSHTKNVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N501</accession>
    <name>A0A1V0N501_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IS605 OrfB family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N501"/>
    <dbReference type="STRING" id="74969.FAD_1356"/>
    <dbReference type="KEGG" id="fai:FAD_1356"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="5">
        <location>
            <begin position="207"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="6">
        <location>
            <begin position="337"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="466" mass="54865" checksum="7697B5B5B8B8D37E" modified="2017-06-07" version="1">MRKRAMMSEERRNKIKNSLRITRERRKTQDVIILKLKIDNDKLNNNTIKALNTIFLEAKWLYNYVINKEFNNDIFNIDPKIKNVNVYVKDHYETRKLKYLSSQMKEEIINRAMDNIRGLHKLKEKGSKIGKLKFKSFITSIPLNQYTITYKIINNNYIKIQNIKQLLKVNGLDNLEYYYEPASALLINKNSYYYIYITAYKNKYILEKPVNNQKIISFDLGIKNQLTCSNGSILNYNIPKSKKEIRLQRSLSRKAKYAEGTKKLSREQSKNYYKNKNRLNREQTKTANKRKDTINKIVHYLTSNYDIVITQKDNISGWKHLFGKRIENTGIGEIIDALKHKASTLILLNQFIPTTKECSNCHNKYDIKLDERIYNCPKCGFIIDRDYNSSLNDMYYGIKKLNELLKIKNRKLNNYFKKYNINLNVPMERRELTPVEIIASGFEGLNISPYVKLSMVNEAGSLNALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N505</accession>
    <name>A0A1V0N505_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142785.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N505"/>
    <dbReference type="STRING" id="74969.FAD_1308"/>
    <dbReference type="GeneID" id="31676803"/>
    <dbReference type="KEGG" id="fai:FAD_1308"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="243" mass="25526" checksum="6550E230E579C740" modified="2017-06-07" version="1">MNKKKVIIGVVMAAIFIMMVFVPVADNTNTAQINTAIPQQVTACQLNNQATPHFLLNHPNITINMVKLQDGFMISTFINGSLSSWVIYQNNIQAGRVNIIAFNDGNFSFYSHNVNESNMTGAVNTSNMANHTQASIAATYTPGDAKYSTGLFGWAASFSPSELELLSIALGSGATVAGVIAFFTTGTIVGIPLAAIPAVAAAIMGVGSVAIGILAYECGNGGYIGTTWFGSPEFGCNPVPWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N531</accession>
    <name>A0A1V0N531_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1342</name>
        <name evidence="9" type="ORF">HLB00_04860</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000165">
        <property type="protein sequence ID" value="NOL60166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142823.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N531"/>
    <dbReference type="STRING" id="74969.FAD_1342"/>
    <dbReference type="GeneID" id="84217954"/>
    <dbReference type="KEGG" id="fai:FAD_1342"/>
    <dbReference type="OrthoDB" id="40089at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11032">
        <property type="entry name" value="P450_EryK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000018">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696:SF1">
        <property type="entry name" value="CYTOCHROME P450 YJIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL60166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="381" mass="43621" checksum="AA7097A37FC63961" modified="2017-06-07" version="1">MGIPTYKQEPFEWYREMRKSSPVYREGNMIHIFKYKTISRILSDHQNFSSQFRDLLGEEMAAMLNEKTTPSILLLDPPLHTTLRSLVGSAFTPRSIELFEPRIRELARMLVHAIVEKENSDVVSDLSYQLPIRVISEMLGVPESDSEIFRDWSDKLATSLGRGPDIETQYDMADYFYKKIDRNSNGNNLISRLSTVEMDGRKLSDKEIAGFAILLLVAGNETTTNLITNAILSLYDHPEIYDDMRKTPSIIPGVVEETLRYRSPVQSTRRYSKIDTEIGGEEILKNDILALYLGSANRDEEVFEDGESFNPYRKEKRHMAFGQGIHFCLGAPLARLEARIALEEFSKAVPGFEIEKPSPDDRIDSDIMYGFRKLNLKVNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N536</accession>
    <name>A0A1V0N536_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142852.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N536"/>
    <dbReference type="STRING" id="74969.FAD_1359"/>
    <dbReference type="GeneID" id="31676851"/>
    <dbReference type="KEGG" id="fai:FAD_1359"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="177" mass="19115" checksum="7B099B4FA36A7648" modified="2017-06-07" version="1">MESNILNPKYKELKAIEMYRNNSTGMDYHKEHKNNWKKSLISIFAIAVLLTSVGVPVYSGLISMENNAIPYEFGNLGKTIQSSSTDVITSGHIAELVDYELTHWGARPTETDIVNFLIGLFIGVGIVVGSGTLATIGFAILWSSWSNVAIIGILALDLSNPVGQALLGSLAIAIVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N537</accession>
    <name>A0A1V0N537_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase mutator family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N537"/>
    <dbReference type="STRING" id="74969.FAD_1400"/>
    <dbReference type="KEGG" id="fai:FAD_1400"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033543">
        <property type="entry name" value="transpos_IS256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217:SF7">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="362" mass="42342" checksum="21F2FB9024DEE0E2" modified="2017-06-07" version="1">MRDLKKWFLNDLMNEEAEEQINASRYERNSNRKDYRNGYKQRSLLTTDGKVILDKPQFRETSFHTAVFDNYSRVERAVESIILESYLSGVSTRSVNKVIKSLDVQVSPSYVSSLSSWLDKTVNEFLERKIDGVYKFIYIDGTYLKIRDNGRYRNKAIYICVGINSDGYREILGASIYDSETEIEWELFFDDLEDRGLNGVELVISDGNKGIREAVKQSFPGSSWQYCHVHFMRNLRKLMGKQQWNDISLLIKQALDNPDILPVLQDKLFDRGLDKCSSMFDRYYDSLYNYRTFNTNIQGLRRLRVSNTIERLNEEIKRRTKKIGAFPSDDSAMRLAGSIMIDTNEEYVTGRKYINMEEINSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N551</accession>
    <name>A0A1V0N551_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1453 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N551"/>
    <dbReference type="STRING" id="74969.FAD_1369"/>
    <dbReference type="KEGG" id="fai:FAD_1369"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058247">
        <property type="entry name" value="DUF1453"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07301">
        <property type="entry name" value="DUF1453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="22116" checksum="17BC158D9759220E" modified="2017-06-07" version="1">MVKLYLILFRMPATVSLYIQNLSVSVAGLNLSNTFLGIALLLIFSRILYRRLKQGINGRQYKTARLFITPTIYFLLLVFFMVAFIGNIDYIIIVILLCVVGIIPGFIYGERVTFFDRNGQIFYKRSPYILTFWAAGFMVRILLEFIFPSNLEIQFIVDTLLAVTLGLIVGESIKTYRKYREYTMENNLTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N556</accession>
    <name>A0A1V0N556_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative molybdopterin binding protein CinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cinA</name>
        <name evidence="2" type="ORF">FAD_1422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142895.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N556"/>
    <dbReference type="STRING" id="74969.FAD_1422"/>
    <dbReference type="GeneID" id="31676914"/>
    <dbReference type="KEGG" id="fai:FAD_1422"/>
    <dbReference type="OrthoDB" id="372037at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050101">
        <property type="entry name" value="CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE AMIDOHYDROLASE PNCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939:SF0">
        <property type="entry name" value="NMN AMIDOHYDROLASE-LIKE PROTEIN YFAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="250" mass="27757" checksum="BB4ED3751636782E" modified="2017-06-07" version="1">MKAVIITIGNEILKGRTVNTNFSDIGKILTYAGYDVIKGIIVPDNLEQIAGAFKEAASIADLIVSSGGLGPTYDDMTLKGFSMAFNLKMERNDNAMNMVLKKVHTLTPEREKMGMIPENSIPIENKAGTAPGIYENISGKVFIILPGVPREVEAIMKEVEQRIRIKDFHYVDRSIDLHDAKESLLAPLIAKLMKEYGDRAYIKTHPKLDNGKPWVEVEVSASGTDTDEVENFVSRILEIIEKEAGKNNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5A8</accession>
    <name>A0A1V0N5A8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroneopterin aldolase</fullName>
            <shortName evidence="1">DHNA</shortName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mptD</name>
        <name evidence="3" type="ORF">FAD_1426</name>
        <name evidence="4" type="ORF">HLB00_03740</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal dihydroneopterin aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000120">
        <property type="protein sequence ID" value="NOL59944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886533.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5A8"/>
    <dbReference type="STRING" id="74969.FAD_1426"/>
    <dbReference type="GeneID" id="16024659"/>
    <dbReference type="KEGG" id="fai:FAD_1426"/>
    <dbReference type="OrthoDB" id="132689at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.20">
        <property type="entry name" value="7,8-dihydroneopterin aldolase (MptD)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02130">
        <property type="entry name" value="DHNA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027508">
        <property type="entry name" value="DHN_aldolase_MptD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036839">
        <property type="entry name" value="MptD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007181">
        <property type="entry name" value="MtpD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04038">
        <property type="entry name" value="DHNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143560">
        <property type="entry name" value="MK0786-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroneopterin aldolase MtpD C-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="118" mass="13807" checksum="60F8E2B4A883FF9F" modified="2017-06-07" version="1">MNDPSRKYFNCTDRERAIFESGIKLGAIFHQFIGVPVNDSNRKDMENAIEKSIKLQPFVESISVKINIEGQRNTSFQYVSLSGDMLDVRLAIRYNDQEVKARMQYMQDLNYPLMYLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5D1</accession>
    <name>A0A1V0N5D1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN-domain RNase, VapC-type toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142927.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5D1"/>
    <dbReference type="GeneID" id="31676983"/>
    <dbReference type="KEGG" id="fai:FAD_1492"/>
    <dbReference type="OrthoDB" id="43721at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="137" mass="15890" checksum="B566E9D218BEDB06" modified="2017-06-07" version="1">MEYIDTNILISLIDKNDSKYNLANKLMKNYDNKIITELNLLEIKSVLSRSGVIEEEIEALDEYLLIKNDIKIVDIDFNRSINTGIDIINSIKLKTLDCLHIANAIIIHADKFITFDKDFKNKERTIKEFGIEIIYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5F1</accession>
    <name>A0A1V0N5F1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription termination factor FttA</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fttA</name>
        <name evidence="15" type="ORF">FAD_1473</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Terminates transcription on the whole genome. Termination is linked to FttA-mediated RNA cleavage and does not require NTP hydrolysis. Cleaves endonucleolytically at the RNA exit channel of RNA polymerase (RNAP); the 5'-3' exonuclease activity of this protein degrades the nascent RNA released from RNAP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions, which are required for nuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Interacts with RNA polymerase (RNAP), interacts with the Spt4-Spt5 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. FttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142922.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5F1"/>
    <dbReference type="STRING" id="74969.FAD_1473"/>
    <dbReference type="GeneID" id="31676966"/>
    <dbReference type="KEGG" id="fai:FAD_1473"/>
    <dbReference type="OrthoDB" id="7155at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004532">
        <property type="term" value="F:RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22532">
        <property type="entry name" value="KH-II_CPSF_arch_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16295">
        <property type="entry name" value="TTHA0252-CPSF-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00870">
        <property type="entry name" value="FttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="TffA_KH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF51">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_TffA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 12" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="13">
        <location>
            <begin position="189"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="14">
        <location>
            <begin position="421"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Metallo-beta-lactamase C-terminus" evidence="12">
        <location>
            <begin position="579"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="637" mass="71903" checksum="97B8722C10C5E933" modified="2017-06-07" version="1">MSFRDYLSEGRSIFDRLYPDNKITEIDYEGSTIVVYTKDQNLFSQRDDLARQIAQELRRRIAIRPDPSIMSDEKEADAKIRGIIPSDAGLQDIYFEPDTGEAVIEVDEPTIANPEIIKSIKAETNWSPRIVRAPPMYSRTVKEVREYLRDVKKERKEFLHNLGIKLTTPLMPGETWIRITALGGHREVGRSATLISTNNSKVLVDCGMININDPEHPWEEAPYLYAPEIQPFTSLDAVVLTHAHLDHSGLLPLLFKYGYTGPVYSTAPTRDLAALLQNDYLKVSHSENHKLSYESKHVREELKHTISLKYNETADITPDIRLTFYNAGHILGSAAVHLHIGEGLYNVVLSGDQKYEKTWLFNPAVNRFPRVETLMLESTYAGRDDYSYTRNEATNTLIDVVNRTFDRGGSVLVPVFAVGRSQEVMLVLEDAYRNKMIPENTKVYLDGMIMEATAIHAAYPEFLNRDLRDEIMIKRENPFLSPIFTSVETRKQRIDVCDSPESKVILATAGMMNGGPVLEYFKTLSADSRNTLAFVGYQADGTLGRRIQSGASSITLSDGGKSTKFDINMAVENAEGFSGHSTKRELLNFIGGMQPRPNRILVNHGDGNKCYDFARLIHTKFGVEAISMKNLETTRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5G0</accession>
    <name>A0A1V0N5G0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2070 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5G0"/>
    <dbReference type="STRING" id="74969.FAD_1531"/>
    <dbReference type="KEGG" id="fai:FAD_1531"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019204">
        <property type="entry name" value="DUF2070_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09843">
        <property type="entry name" value="DUF2070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2070" evidence="2">
        <location>
            <begin position="26"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="593" mass="67256" checksum="E278DD45C4E04DD7" modified="2017-06-07" version="1">MLIAKNRNNLYVIFQFPGVQKEKTLAGLSRYIKKSPKWYYFLIPIIAIFLIDGIILRNLDALSFMSILPFIFFLLLDALTIKLTNKKFNNNRIMYLDFISLTLVTLFFWIGVLLYPVIRMPLYYILALAIAFPAFLRFLVLYIYYPSNIYLAATLSMNYTFSYIIIALIFYDISKIAIKFIIPLIAATVIYVLFSYIFLVFTTIGFTRKYKSRPSELIDFFLNRDNDGAIGEKFFTHVYNKKRQIPVITTNIRKENRDLVTLVFPYVHPGPFGNLCTSNLPVKISSEMGRDNIMVFHTATTNSNNCSGKNDIKNIAESVKDSIKKMKYSDTVSDFVKFNVDGYDVSLQKFGNSGISAVIPFKKQFDDISIDAGLKVVAALKKNGAENFALLDAQNSFTRDAKELDNCDMIINPLIEKFKATGSTYPAIIGYARNYEKIDGLASMGVQVLAIKINDYYNVIVLTDSNNIGREVIKMARSGVDKRVKNMDIYTTDNHVVNVSELDINPLGMHCEPQVVADLINRTVLQAIEDASPATAGTYTENITVTMGEENAFHNLMEIVIASLRKAKYSIAFILLISILVSSFSFRYMVLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5K7</accession>
    <name>A0A1V0N5K7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">FAD_1582</name>
        <name evidence="12" type="ORF">HLB00_08250</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000308">
        <property type="protein sequence ID" value="NOL60817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142967.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5K7"/>
    <dbReference type="STRING" id="74969.FAD_1582"/>
    <dbReference type="GeneID" id="31677072"/>
    <dbReference type="KEGG" id="fai:FAD_1582"/>
    <dbReference type="OrthoDB" id="372247at2157"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="293"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="325"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="411"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL60817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="426" mass="47722" checksum="45518DA17399D334" modified="2017-06-07" version="1">MISVILGLQFGDEGKGKITDFVSRDYDEVVRFNGGSNAGHTVVIKGEKFKFHLVPSGAMQSNKVILGNGMVIDPEELVSELDLLKKSKKDIEIKISAGAHIVTKMHKCLDKKEEEIRSKLNIGTTSQGIGPTYEDKYARTGIRFIDLSNPEIIEDKIETIYNMKKQLLKGSIFENPEERAKMVKDLCGFGNSIMQYMDYTENVINNDYRLGKNILFEGAQGGMLDIDFGIYPFVTSSNTLAGALSTGSGFSFRKVDRVIGVFKAYTSKVGSGPFPSEIIGDSTLRDLGSEYGTTTGRPRRVGWLDLPLLKYTIMMNDVDSLAITKVDILGKMKTIKIATNYTIDGKEIDYFPRRLEDFEKLHVDYVELPGWGDIENPDDIIANGYQALPQNMKKYIEFIEEKTGKTIDIISLGEDRRMTITKQIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5M6</accession>
    <name>A0A1V0N5M6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA double-strand break repair Rad50 ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rad50</name>
        <name evidence="12" type="ORF">FAD_1563</name>
        <name evidence="13" type="ORF">HLB00_00995</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per homodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886705.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5M6"/>
    <dbReference type="STRING" id="74969.FAD_1563"/>
    <dbReference type="GeneID" id="16024834"/>
    <dbReference type="GeneID" id="31677054"/>
    <dbReference type="KEGG" id="fai:FAD_1563"/>
    <dbReference type="OrthoDB" id="25344at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.510">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00449">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022982">
        <property type="entry name" value="Rad50_ATPase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32114">
        <property type="entry name" value="ABC TRANSPORTER ABCH.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32114:SF2">
        <property type="entry name" value="ABC TRANSPORTER ABCH.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75712">
        <property type="entry name" value="Rad50 coiled-coil Zn hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="11">
        <location>
            <begin position="401"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="186"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="482"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="628"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="697"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="32"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL59416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="894" mass="102878" checksum="C57E83E039607FA7" modified="2017-06-07" version="1">MIIESIKIINFLSHENTEITFEQGINIITGKNGAGKTSILDAIKFALFAESRNNEKNNELIKKGKNYFEITLNFNVNGEHYEVYRHFGLKKAKNAERLASVKKNGVIVAETYEGVNVEITKILNVSREVFKNSVFVEQGQMDSLISGTPKERKTIFSDIIGLTSLSRSADRLREIIGAFREEMILLQNSSERLDQAKKDIEKFKEEKKTAFESMSRAKIESEKYYGELEELKAKQKERDRYITVIENIKANISKYLDEIKEREGQSVELSAKISEITSIEKRVTELQENPYYKKMDFINRYFLEKSGMDSAAKDMEKANKRLSEYSDYAGKLEKLSEYHKKYSDMHDKYTLNSEKIKESRKMHEEYLSASSNIQSMVDRLNKMKNYVDNYLKSSGLSLEDIQNFRPIREKINREISEKTSRISEIKSNVASYSKTLTEVRENMETLKGKSTCPLCGTNLTPDHMESISKEYDEKAGQIIGDIEKLKLEKNSVESDQEKLKDRYKIFGSQEIETAASYINEIKSLETEKKELENTIENASKGHELFNVLSAENENLEKAIKELQQYENEYIRYSSIISGMDPGAIKKEIEAAGESFTTFKNRINELLSQIGFVPEYNEYQNTGKISSEINRLKTEVERSREMKSKLESIKDEIENRKKSIEGLRIEMENKQSAMHQYDGIDEQAGNIESRYKSAYQENIKMKTLVDSYTERIEETEENAKNLEQDAEKYKKTREAISTLGKIREAFDYNGIQSIIRKDASASMTNLTRKYLQSFNLDFDDISIDENFDIKVTQNSMEQTLESLSGGEKTALAIAIRLSVTEYVLEIISIIIMDEPTNFLDEDRRNNLKDIILYSLKGENIVPQMIMITHHSELISVADASYEIIKTAGTSRVISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5M9</accession>
    <name>A0A1V0N5M9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1555</name>
        <name evidence="9" type="ORF">HLB00_00955</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886697.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5M9"/>
    <dbReference type="STRING" id="74969.FAD_1555"/>
    <dbReference type="GeneID" id="16024826"/>
    <dbReference type="KEGG" id="fai:FAD_1555"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="18"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="460" mass="50036" checksum="04C8751DB0005B76" modified="2017-06-07" version="1">MGYNALDNARINSLHKKITALSVGGTFLDGYDISIISVALIVMSKTAFGLDTDFGKAMIAASTTIGMLVGAILFGYITDLYGRRTMYMYDMALFIVLTAAEAFSWSFASLFIMRFILGLGLGADYAIGTTIIGEFSPVKYRGKLLVTNVLSWFLGAAVAAVTGYLLLPLGNESWRYMFLLGIIPAAIILVLRRDVPESPRWLSNKGNASEAEDIERRLTGTSDNLTAIKRDNKNPLKELLSRKYIKSLLFVGIFWFTFDAAFYGISIFSPTILELLGLKARLAVLGSAVFDTFAIIGSLIAILLIDRIGRKGITIIGFSGMVISLLSLGIITFYVPDRSAFITDGILIFALFLIFYITEAIGPGSTDFVYPVELFPTEDRASAQGFGTSVSRIGAILGITTFPFIVSIYGFSTSLFFFTGLSVIGLLATIFLATETKGKTLEQVNEIEEGKISKFKAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5S2</accession>
    <name>A0A1V0N5S2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1600</name>
        <name evidence="7" type="ORF">HLB00_01580</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000042">
        <property type="protein sequence ID" value="NOL59527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142979.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5S2"/>
    <dbReference type="STRING" id="74969.FAD_1600"/>
    <dbReference type="GeneID" id="31677090"/>
    <dbReference type="KEGG" id="fai:FAD_1600"/>
    <dbReference type="OrthoDB" id="372184at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18093">
        <property type="entry name" value="SpoU-like_TrmJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786:SF2">
        <property type="entry name" value="TRNA (CYTIDINE_URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="TRNA/RRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="236" mass="26550" checksum="5BA8CEC174C672D6" modified="2017-06-07" version="1">MLDLDKIISVVLVEPKYQGNIGAVARSMANSGISDLRIVKTPIETEAIYRSMHGRYILENAKIFNSLKEAVSGFEIIAGTSDISKSGEKFRRVPTGPEEFWSTNGLTGQKVALVFGREDNGLNYEELGMCNFFLKIIGNPEYPVYNLSHAVAIILYEMIKANYSCNATITHDLIGRDKIDTLAGRLEELLAKIDYNEQEIDTLMNMLNRIIARANITDSEFFKIMGIMRQTINRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5S3</accession>
    <name>A0A1V0N5S3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpl12p</name>
        <name evidence="4" type="synonym">rpl12</name>
        <name evidence="6" type="ORF">FAD_1617</name>
        <name evidence="7" type="ORF">HLB00_01665</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000043">
        <property type="protein sequence ID" value="NOL59543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886748.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5S3"/>
    <dbReference type="STRING" id="74969.FAD_1617"/>
    <dbReference type="GeneID" id="16024882"/>
    <dbReference type="GeneID" id="84218211"/>
    <dbReference type="KEGG" id="fai:FAD_1617"/>
    <dbReference type="OrthoDB" id="3337at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_P1_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="101" mass="10964" checksum="441F0285DD3DA569" modified="2017-06-07" version="1">MEYIYGALLLHSAGKEIDEENLKKVLTDAGVAADDARLKSLLESMKNVNIEEVLKNAAAAPVAAAPAKEEKKEEKKKEEKKEEKKDESDSDAMAGLSSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5S9</accession>
    <name>A0A1V0N5S9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5S9"/>
    <dbReference type="KEGG" id="fai:FAD_1639"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="360" mass="38864" checksum="6F065BF63BF86050" modified="2017-06-07" version="1">MAAIFVILAFVPVADNIHSVQSNKAPGNISPQVAIGKYVVNKSQPTTTTNSNLSNKIAVSFSSWYMKNHVKENLPEISSTTGQSLFMQYINQSIAGKAYISQLTANEKSSFNKSNKMEVSSIESILHSGHKVPSVINGKDSMSYVLNIMADLPGGVSSDSGTWVMVTINYFVYHAPWWLGGWTVTYGEQDDFNELWAGSTAQKEYNSFEKYMTLDGIASGAAASGLTGYVLAGAIGGSWGGPVGTIVGAVVGIVAGLVIMHIDDAMTKLYESTYANEPSGNKYIWTYMMNDYYYPWITVVGSLASSIGFYGHLSNGNTVTIFQNTPLGVFGGVPGVVISGYFSSYVHYLGNKYGENNWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5X0</accession>
    <name>A0A1V0N5X0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1708</name>
        <name evidence="10" type="ORF">HLB00_00085</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000005">
        <property type="protein sequence ID" value="NOL59237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143042.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5X0"/>
    <dbReference type="STRING" id="74969.FAD_1708"/>
    <dbReference type="GeneID" id="84218328"/>
    <dbReference type="KEGG" id="fai:FAD_1708"/>
    <dbReference type="OrthoDB" id="8186at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00423">
        <property type="entry name" value="CofH family radical SAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="FO SYNTHASE (COFH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076:SF14">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004762">
        <property type="entry name" value="CHP00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01064">
        <property type="entry name" value="F420__menaquinone_cofactor_bio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01389">
        <property type="entry name" value="menaquinone_synthsis_involved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="51"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="368" mass="41647" checksum="F201BC16594664D5" modified="2017-06-07" version="1">MSIAYNKDYWFDFLKDNEIKEKDAHELLNMDIYSLMSLGDSLASREVGDKVSYAVSYNINYSNFCTASCPICAYYVPYKIKKYNPEKGFELSVEDVHKEAMKAKELNVTEIHIVGGFNPDLNLEYYENIFREVKKVLPDITLKTFTIPEIDFIARTTGNSIPEVIDRFRKAGMDAHTGGGAEIFNEEVRKQITTPEKISGEKWLEDAKLIHSLGVKGNSTMTYGTVENYDDIINHMVRLRDNQLEQPGFLSFIPLKFSIENTPLYKMGKVRMPASGDKDIRVYALARAILGKAIRNVSVYWVALGKELAQVALMSGGSDLVGTAFSEKVFGATNRHTSGSVEELNHLIEEIGKVPALRDTFYNIKEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N615</accession>
    <name>A0A1V0N615_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143031.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N615"/>
    <dbReference type="STRING" id="74969.FAD_1694"/>
    <dbReference type="GeneID" id="31677186"/>
    <dbReference type="KEGG" id="fai:FAD_1694"/>
    <dbReference type="OrthoDB" id="43034at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041656">
        <property type="entry name" value="TPR_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12688">
        <property type="entry name" value="TPR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetratrico peptide repeat group 5" evidence="1">
        <location>
            <begin position="39"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="156" mass="17665" checksum="1FE2A8FC73C99280" modified="2017-06-07" version="1">MKSPNNIIEEAWKYQDKPEIMLKIFQESYDDFSENAAYLFEYANVLDFLGKETEAIPLYEKAIKLRLTGKMKIQAEMQLGSSLSIKGEHESAIAILDGVYKDTADPASLEFLCIALFRSGQADKALKYALNFILSSNQGMLPEYSRALSDYVNEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N617</accession>
    <name>A0A1V0N617_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Virulence-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N617"/>
    <dbReference type="KEGG" id="fai:FAD_1687"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051749">
        <property type="entry name" value="PINc/VapC_TA_RNase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42740">
        <property type="entry name" value="RIBONUCLEASE VAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42740:SF1">
        <property type="entry name" value="RIBONUCLEASE VAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="103" mass="11527" checksum="F97B0960E2D2B75C" modified="2017-06-07" version="1">MSKIIDSGEYYCTSSINLHEVLYGIKKYSKDSKLVMQIPVLGYRKSDTELSVDLELSAERSGKAIPRIDVIIAAIAINNGCSLYTLDNHFEVLTDIGLKLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N625</accession>
    <name>A0A1V0N625_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LysE family transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143039.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N625"/>
    <dbReference type="STRING" id="74969.FAD_1705"/>
    <dbReference type="GeneID" id="84218325"/>
    <dbReference type="KEGG" id="fai:FAD_1705"/>
    <dbReference type="OrthoDB" id="121309at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38825">
        <property type="entry name" value="LYSINE EXPORTER PROTEIN (LYSE/YGGA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38825:SF2">
        <property type="entry name" value="LYSINE TRANSPORTER LYSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20606" checksum="376A30DCA5682D7F" modified="2017-06-07" version="1">MFLYDYGLGILLGLSLAGPPGSVNSIIANEALKSPLHGTLVGLGAMTADLTFFAIVFLTNGIISPTILKVIYIIGGIFMLYLGISILRSKMPSKTRKGNYVLGVTMGLTNPFQIIWWFTVGFFLLKELSIFSITGLYSGIVVWTIVFPYVVWRFGTGYEKYIKIVSAAIIFAFAIYILFDGLHLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N645</accession>
    <name>A0A1V0N645_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="11">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">metS</name>
        <name evidence="11" type="synonym">metG</name>
        <name evidence="15" type="ORF">FAD_1764</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143075.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N645"/>
    <dbReference type="STRING" id="74969.FAD_1764"/>
    <dbReference type="GeneID" id="31677255"/>
    <dbReference type="KEGG" id="fai:FAD_1764"/>
    <dbReference type="OrthoDB" id="371856at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02153">
        <property type="entry name" value="tRNA_bindingDomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 11 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="14">
        <location>
            <begin position="544"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="334"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="701" mass="80646" checksum="7FD243BD49AF6D8A" modified="2017-06-07" version="1">MEREKILVNCALPYANGPLHLGHIAGAYLGADIFVRFNRMSGNEVLFISGSDEYGTPITISAEKNHVPPQEIADKYHIEQINSFNSMDIIFDKFTRTSDPEHVKDVDEFFINLLEKGYLVKRYMISPFCVEINKFMPDRYIEGECPYCGYKEARGDQCDNCGQTLDPIELINPICKMTGNSPIFRVTDHFFLKLDSLQEKLAEFIDSKTYWRPNVLKFTQNFIGEGLHPRAITRDLDWGVKIPLKGYENKKIYVWFEALIGYITGARVYSEETGKPDYWKEFWMDKNIKSYYFIGKDNIPFHTIIWPAMLLAHGGFNLPYNVPANEYLRFEGEKFSKSRGIGFTVDEMLKFVDKNSLRYYMSSVLPETGDSDFSMNEFQLKVNSELIDKYGNYIYRVESFIEKNGLSPHEPETMDAKDREMMKFLEDKFSEYSMEVSGIHIKRGISIWLEIVMAANNYFTESAPWKLIKEDMEKLNEKLYVSLKIGQYLTAMLYPYVPSAAESIWQTFGISENLENATFNDVLKINKFNIKKGSIPFEKIDFSNPDILDIQLATIVSVEDHPGADSLYSIKLHGDKIYQTVSDLKKYYTKSDLQGKQVLILTNIEKARIRGVESQCLILSIWNGNSKEVISSTGNDGDFATLGKYRYNGEETLTFKEFQKMEFTVSDHHIIAKLQEESLPVMLNGKDVNVSIENLDKASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N694</accession>
    <name>A0A1V0N694_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase II small subunit</fullName>
            <shortName evidence="15">Pol II</shortName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exodeoxyribonuclease small subunit</fullName>
            <ecNumber evidence="15">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">polD1</name>
        <name evidence="15" type="synonym">polB</name>
        <name evidence="17" type="ORF">FAD_1785</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EC" id="3.1.11.1" evidence="15"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143088.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N694"/>
    <dbReference type="STRING" id="74969.FAD_1785"/>
    <dbReference type="GeneID" id="84218408"/>
    <dbReference type="KEGG" id="fai:FAD_1785"/>
    <dbReference type="OrthoDB" id="372039at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04490">
        <property type="entry name" value="PolII_SU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00325">
        <property type="entry name" value="DNApol_II_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011149">
        <property type="entry name" value="Pol2_small_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003118">
        <property type="entry name" value="PRK04036.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000803">
        <property type="entry name" value="Arc_Pol2_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="16">
        <location>
            <begin position="216"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ARD85624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="467" mass="53109" checksum="8132D5F192C50602" modified="2017-06-07" version="1">MDLIENRKEVLVYFQSKGIMVTKKALDVILDSSMGELLPKMVTQEVLDTGFLTENDVIKLIRSPQRKKMDFEVYIPDIKAHSSVEDFQEMFMDRYERLKKIIVQSSEMRGTYTIKSAKKAQGKVKIVGMVSEVSTTKNGHKRLLLEDLDDNINVFLLKGKGMNNELILEDEVLGVIGSVSNTGKDPVLFADEIIRPDIPYKLIDEQKKDPVFVASLSDIHVGSKTFRKNDFMKMISWIKASEEEASKLKYLILSGDVVDGIGVYPGQDKDLEILNPYEQYEKLAEYVNMVPDDVNVFIMPGNHDIVRLAEPQPVFSQKIKNFFNENVTLLPNPYNLVLENKNVLVYHGMSLNDMIELVPGASYASVGSSIEELLKRRHLAPVYGGKTPIIPSKRDYHVIDQVPDIFITGHIHSFSQGSYRGVRYINASTWQSQTDYQKMMNFSPNPSIMTLFDLNSKTQIIKDFKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-02-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E5KBS2</accession>
    <name>E5KBS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1727</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Proteomics" volume="11" first="52" last="63">
            <title>Iron homeostasis and responses to iron limitation in extreme acidophiles from the Ferroplasma genus.</title>
            <authorList>
                <person name="Potrykus J."/>
                <person name="Jonna V.R."/>
                <person name="Dopson M."/>
            </authorList>
            <dbReference type="PubMed" id="21182194"/>
            <dbReference type="DOI" id="10.1002/pmic.201000193"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HM998294">
        <property type="protein sequence ID" value="ADR78325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143060.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E5KBS2"/>
    <dbReference type="STRING" id="74969.FAD_1727"/>
    <dbReference type="GeneID" id="31677218"/>
    <dbReference type="KEGG" id="fai:FAD_1727"/>
    <dbReference type="OrthoDB" id="56796at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADR78325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="191" mass="22760" checksum="7B6D321A2F70EA26" modified="2011-02-08" version="1">MIKPDDSIIVLVNYNTEFFRNCFSKMEFLMGMDYINNFIDKYRVPVIFTERELDYTVENPELLKLRTRKEENRMKNMAPPSDYDKGFIEEFNKKIKVNNTVKTWKEDIFYRSSLEEEISKTGRRSIFLGGFFTDTDIFISSANANIREYNTIVVSDITSTYSERLYFQSLEMISQFVDVTDTRDLEQYYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1G3</accession>
    <name>A0A1V0N1G3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF763 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0024</name>
        <name evidence="2" type="ORF">HLB00_05650</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000190">
        <property type="protein sequence ID" value="NOL60317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141243.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1G3"/>
    <dbReference type="STRING" id="74969.FAD_0024"/>
    <dbReference type="GeneID" id="84218514"/>
    <dbReference type="KEGG" id="fai:FAD_0024"/>
    <dbReference type="OrthoDB" id="9948at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="BLL3834 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597:SF1">
        <property type="entry name" value="BLL3834 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD83959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="352" mass="40378" checksum="646DCF03899BEC21" modified="2017-06-07" version="1">MQNHGSSIMPLHYGHPPEYLYKRMVKLGGIISDLMIQNYSENFFLEKIADPFWFHSLSLAIGFDWNSSGTTTATLSALKDHINRGDSLRIIGGKGKHMGNIGQEIAMIESEGNIEDKYLYRIKKDAKSIAKVDEKLLQDGFNLYMQFILMDYKGNYTIVNQGMNTVSSLARRYHWKNNDISLYDDKRNGISGYEENIALDLSTRKSEKNREGIINIIQDNPIKYSKQRSLDNFMESAPVLDLNYKINWQKMKELYEYNPGKFDELMDMPGISKSTIRALSYLAEIVYGDKPSFADPVKYSFCLGGKDGVPKPVNVNDYDEAIKFYKEILNGNSNYAEISKRLARMSYRISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1H5</accession>
    <name>A0A1V0N1H5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-6-naphtoate synthase</fullName>
            <ecNumber evidence="3">4.1.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnD</name>
        <name evidence="4" type="ORF">FAD_0053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6-naphthoate + dihydroxyacetone</text>
            <dbReference type="Rhea" id="RHEA:33087"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:64254"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="4.1.99.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.29" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074177.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1H5"/>
    <dbReference type="STRING" id="74969.FAD_0053"/>
    <dbReference type="GeneID" id="16025199"/>
    <dbReference type="KEGG" id="fai:FAD_0053"/>
    <dbReference type="OrthoDB" id="49741at2157"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00996">
        <property type="entry name" value="MqnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="1,4-DIHYDROXY-6-NAPHTOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167:SF1">
        <property type="entry name" value="1,4-DIHYDROXY-6-NAPHTOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD83988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="271" mass="31200" checksum="8D2BD5DCECBA4D93" modified="2017-06-07" version="1">MKMLIAHTPDPDDAFMFYAMFEHKIKTSFEYDQVVKDIETLNKESVDLKYDVTAISANGYMHVSDKYDLTTSGASFGISYGPQVIAKKNIDLKGKTIASPGKYTSAELLYRMFAPEAGTLKEIRFDKIVNAIMENEVDAGILIHDEQLTYQDKGLVPVLNLYDEWKKYAGDLPIPLGFNAIRKDMPIEDKLKYKADFENSIKYAFEHETDAVKYAMKYSRYDDFELERKFILMYVNELSVDFGEKGRKALDLYYKRAAEKNIIKPFKPTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1I4</accession>
    <name>A0A1V0N1I4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CDP-archaeol synthase</fullName>
            <ecNumber evidence="11">2.7.7.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">carS</name>
        <name evidence="12" type="ORF">FAD_0022</name>
        <name evidence="13" type="ORF">HLB00_05660</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:25690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:58838"/>
            <dbReference type="EC" id="2.7.7.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-archaeol synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.67" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000190">
        <property type="protein sequence ID" value="NOL60319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141241.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1I4"/>
    <dbReference type="STRING" id="74969.FAD_0022"/>
    <dbReference type="GeneID" id="84218512"/>
    <dbReference type="KEGG" id="fai:FAD_0022"/>
    <dbReference type="OrthoDB" id="45383at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043338">
        <property type="term" value="F:CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01117">
        <property type="entry name" value="CDP_archaeol_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032690">
        <property type="entry name" value="CarS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002726">
        <property type="entry name" value="CarS_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003114">
        <property type="entry name" value="PRK04032.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39650">
        <property type="entry name" value="CDP-ARCHAEOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39650:SF1">
        <property type="entry name" value="CDP-ARCHAEOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01864">
        <property type="entry name" value="CarS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD83957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL60319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="185" mass="20467" checksum="A6DD939115B6604F" modified="2017-06-07" version="1">MGNIVLFTLYAIILFAPAFIANPGAVITGGHWVIDRGKTYKGKRILGDGKSWSGFIGGSLIGILSGIIIYYIVIVLRIPYPDYGKNIIDAILVLIPMSFGSLLGDMSGSFIKRRIGMKRGARGSILDQWPFVIVSFLLVFIFARGFFMQLYGDLIPVAVILIITPPIHRGVNILAYKFKMKDVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1J1</accession>
    <name>A0A1V0N1J1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase M48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_0026</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141246.1">
        <property type="nucleotide sequence ID" value="NZ_DAIDCF010000032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1J1"/>
    <dbReference type="STRING" id="74969.FAD_0026"/>
    <dbReference type="KEGG" id="fai:FAD_0026"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050083">
        <property type="entry name" value="HtpX_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43221">
        <property type="entry name" value="PROTEASE HTPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43221:SF2">
        <property type="entry name" value="PROTEASE HTPX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="12">
        <location>
            <begin position="165"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD83961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="334" mass="38547" checksum="F4B08D90150A12CF" modified="2017-06-07" version="1">MDNFQKRIIIGTLYPISIFLFIPSIIIYHFTLLIWLITLTGSEFVAFILVFLGYLIDRKDKGITATFAEYLKFNSYGPLIVLILFFMFVSGYYIMTHTYIDTLIYINIVLIIFILLVLLQPISNIKYNRIPSIENNEDTKIQSILKVFRDYNITPHIKIIDTNSVKIANGYQSDKYYIYITSYLLSNLSESELEAVVAHEIGHLVMKHNLKHFLISWLALVFGINAFLLSFIEKKFYILIPIAIIFLYIFATLILPLLQRSDEVKADLFACKAVGADTVKSALVSIDNLNKTPLKFSPKYMYTFSLTLSHPSTTVRIKKINEWSQKHGEDKFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Q6</accession>
    <name>A0A1V0N1Q6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0088</name>
        <name evidence="3" type="ORF">FAD_0695</name>
        <name evidence="4" type="ORF">FAD_0728</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887387.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Q6"/>
    <dbReference type="STRING" id="74969.FAD_0088"/>
    <dbReference type="GeneID" id="16025533"/>
    <dbReference type="GeneID" id="31676230"/>
    <dbReference type="KEGG" id="fai:FAD_0088"/>
    <dbReference type="KEGG" id="fai:FAD_0695"/>
    <dbReference type="KEGG" id="fai:FAD_0728"/>
    <dbReference type="OrthoDB" id="110773at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053172">
        <property type="entry name" value="Tn903_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053520">
        <property type="entry name" value="Transposase_Tn903"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033579">
        <property type="entry name" value="transpos_IS5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631:SF3">
        <property type="entry name" value="ISSOD12 TRANSPOSASE TNPA_ISSOD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="128"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="307" mass="36169" checksum="D2281DB01B83375B" modified="2017-06-07" version="1">MTPQINNKINRSIKRYWIGSNRRWEKYNESLVDRVEYLTDLSFIKDYDTLLEEKNSGKIGHPYKVPDALIMYLARLRSIFNVPFRSLEGILRSLAIITGIKSISYSEIFRRIRRIKPELNNINNKLDCIIDSTGYKITIRGDYLGHKWHKKRKGWLKLHVIISLKDVNVLSFTITDEHTHDSKAARKLLSKMKNNILRIFGDRGYDSKYIYNMFGYNAVIPPRKNASTKSRGSSTRAKIVRFIKKNSMEQWKENNSYGKRWIVEIYFSGLKRVMTEVIKAKKIEYIIQELALKVVNYNIMRGMTHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1R3</accession>
    <name>A0A1V0N1R3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl23</name>
        <name evidence="7" type="ORF">FAD_0160</name>
        <name evidence="8" type="ORF">HLB00_02220</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000069">
        <property type="protein sequence ID" value="NOL59649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887165.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1R3"/>
    <dbReference type="STRING" id="74969.FAD_0160"/>
    <dbReference type="GeneID" id="16025309"/>
    <dbReference type="KEGG" id="fai:FAD_0160"/>
    <dbReference type="OrthoDB" id="7751at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_uL23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="82" mass="9403" checksum="32A1A76B3D873DE0" modified="2017-06-07" version="1">MDYVISPVVTEKTTLMMEKENKLTFIVDRRGRKKDIKKEIEERFDVKVIGLNILITKKGKKAIAKLSDDYSAEEIGGRIGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1V2</accession>
    <name>A0A1V0N1V2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1V2"/>
    <dbReference type="STRING" id="74969.FAD_0146"/>
    <dbReference type="KEGG" id="fai:FAD_0146"/>
    <dbReference type="OrthoDB" id="57162at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051684">
        <property type="entry name" value="Electron_Trans/Redox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30176">
        <property type="entry name" value="FERREDOXIN-TYPE PROTEIN NAPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30176:SF3">
        <property type="entry name" value="FERREDOXIN-TYPE PROTEIN NAPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="681"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="742" mass="83999" checksum="2B968C02FAC738B1" modified="2017-06-07" version="1">MHSHMFDTIFLIGIMTIIFMVTYIIFVFSYILKHKNDISFLRIAAIGIFTAMMASMLDAFLLYITTVHNFLDTGLAFTFGMILMSQPIVAVFVGVMHGGLDRKGLTKANATAFTGLIIWNEVSMGLFLFYLFNPTIIHFDYYHAIYSFDFVSALSNGINTIYFIVPMSIEMFALFLVYKPKGMHRYAAISIFTMDLFAPTLLGNDKFVFIGGVGETAIMIIFMIIFFEFIAKHKLILPKDDAYHIKMIFIDYLLMGIGTFIGTIILKPFGFAWIFFAVAILFGMWYYFSSMFSVKTPSINVTKTENNVVIKRKKIINKPARLIFFVLVASFVSELFMAGSMDFATYNYLPFFRAIDTLPSFHGVSVAGFYAHDVLREFVSPFVPASTGTYNFLMFYGMVGGVYKFTPVSTFIEILYIIGYITDSPTFLIIMGTEMIALVIARMRVLKDRGKKINLAFAITAYILYTTVGPNFLNPLYYNKLPFWANTGAQAALYPYLVIPLLGSYALYAFLALLFGRRSYCSTLCPSAVMYGGTLGQAMGRYNWEAKPSRKMRSSHFTDSILFIASGAWIWAILASLFSYMYTATGSLSFSIYGIDPSVFYSYFIWNILWYVFFFSIPFVGMSPCRKYGWCSTGTLVGFFSVLGFFKLKVKDKNVCRTCETKACATSCEVGISTLPGQFIEKGSFKSVKCVGAGDCKRACPYDNIYFYDVRNFLRERLGTGRKNKDYSSDIVMVKKNSGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Y0</accession>
    <name>A0A1V0N1Y0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Large ribosomal subunit protein eL37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpl37e</name>
        <name evidence="12" type="ORF">FAD_0189</name>
        <name evidence="13" type="ORF">HLB00_05895</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000197">
        <property type="protein sequence ID" value="NOL60364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887194.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Y0"/>
    <dbReference type="STRING" id="74969.FAD_0189"/>
    <dbReference type="GeneID" id="32192135"/>
    <dbReference type="KEGG" id="fai:FAD_0189"/>
    <dbReference type="OrthoDB" id="5619at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000003">
        <property type="entry name" value="50S ribosomal protein L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 11 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL60364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="54" mass="6272" checksum="0272C9D49CA52495" modified="2017-06-07" version="1">MSNGTASMGKANTKKIHIRCRRCGHNSYNVREKRCSYCGFPSPRIRHYNWAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Z3</accession>
    <name>A0A1V0N1Z3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0198</name>
        <name evidence="3" type="ORF">HLB00_05850</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000196">
        <property type="protein sequence ID" value="NOL60355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887202.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Z3"/>
    <dbReference type="STRING" id="74969.FAD_0198"/>
    <dbReference type="GeneID" id="32192136"/>
    <dbReference type="KEGG" id="fai:FAD_0198"/>
    <dbReference type="OrthoDB" id="57038at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="239" mass="26713" checksum="56C88958226E9C00" modified="2017-06-07" version="1">MDTSKYIITTRPGIKFKPVKTQCIDILNIPLTSIQARNFDENIGKELIQAKPGVIVLTSSFGAMEFFKNYYKFTVNPDFVAIGEKTAGIIRKYAGNVKVPTVKDSYGVLDLLSGYENTDIALFRSNESNNIIRESLTRRGVKYHEYHVYDVIQLENTGLKDSFLSSSCNGILVTSSMEARIFRETIGTYTGGKKIYSIGKITTSTLESLGYKVSLTGNSDFEAMIEKIDKENCNSGEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N204</accession>
    <name>A0A1V0N204_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0195</name>
        <name evidence="3" type="ORF">HLB00_05870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000197">
        <property type="protein sequence ID" value="NOL60359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841607.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N204"/>
    <dbReference type="STRING" id="74969.FAD_0195"/>
    <dbReference type="GeneID" id="16025341"/>
    <dbReference type="KEGG" id="fai:FAD_0195"/>
    <dbReference type="OrthoDB" id="56053at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43252">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR YQJI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43252:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, PADR-LIKE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator PadR N-terminal" evidence="1">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="175" mass="20440" checksum="60D914B5A3C2F1E6" modified="2017-06-07" version="1">MYGKRYSEKDEKDCNGMNGEMGHRMGNMGHHRMGSGENRRGMHGFGLKYLILNMASSEEITGVDVIDRVDRRTEGRWVPSPGVIYPALRKLYEEGYLEMREDNNKKYYKATEKGKEVVKDTIFPWNQRKEEINSIDTILERMEDYAQFIIDNSSKLNDTEKDRIKKINSQLGTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N222</accession>
    <name>A0A1V0N222_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0232</name>
        <name evidence="3" type="ORF">HLB00_09720</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000433">
        <property type="protein sequence ID" value="NOL61095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887240.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N222"/>
    <dbReference type="STRING" id="74969.FAD_0232"/>
    <dbReference type="GeneID" id="16025385"/>
    <dbReference type="KEGG" id="fai:FAD_0232"/>
    <dbReference type="OrthoDB" id="56938at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22231">
        <property type="entry name" value="RHH_NikR_HicB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="entry name" value="Met repressor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="Ribbon-helix-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribbon-helix-helix protein CopG" evidence="1">
        <location>
            <begin position="6"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL61095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="96" mass="11102" checksum="32DEBCC15DAF126D" modified="2017-06-07" version="1">MSVPYRITIRVSEDLINQLQEIVEKNQYSSISEAIRLAISEFITKNRENATSKVDLKLPRNIYTELEEEVNNGNAISVNDLIRFILREYAKGKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N241</accession>
    <name>A0A1V0N241_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF488 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887258.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N241"/>
    <dbReference type="STRING" id="74969.FAD_0241"/>
    <dbReference type="GeneID" id="16025404"/>
    <dbReference type="GeneID" id="31675749"/>
    <dbReference type="KEGG" id="fai:FAD_0241"/>
    <dbReference type="OrthoDB" id="7940at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052552">
        <property type="entry name" value="YeaO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36849:SF1">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36849">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22752">
        <property type="entry name" value="DUF488-N3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="14206" checksum="C4BF2850212F132C" modified="2017-06-07" version="1">MIYIKRIYDKYTPEEGFRVLVERLWPRGISKEKAHIDLWMKDIAPSTELRKWFNHEDEKWEEFVKRYTIELSGNEEIGKLKELVKEHTKVTFVYSARNVEHNSAVALKNIVESIDSHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N256</accession>
    <name>A0A1V0N256_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841622.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N256"/>
    <dbReference type="STRING" id="74969.FAD_0247"/>
    <dbReference type="GeneID" id="16025413"/>
    <dbReference type="KEGG" id="fai:FAD_0247"/>
    <dbReference type="OrthoDB" id="5620at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022563">
        <property type="entry name" value="DUF3463"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050377">
        <property type="entry name" value="Radical_SAM_PqqE_MftC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023863">
        <property type="entry name" value="rSAM_PTO1314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03961">
        <property type="entry name" value="rSAM_PTO1314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228:SF7">
        <property type="entry name" value="PQQA PEPTIDE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11946">
        <property type="entry name" value="DUF3463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="22"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="341" mass="39623" checksum="297C3A8D3272D826" modified="2017-06-07" version="1">MSVYNAVVLRSIKRNMSRVKNKKLPTIAGHKLLYECNLRCKMCPFWRRPDSKLLSMEQEIAMMEKLKEGGVSYLGFEGGEPLLRNDTPEILKESHKRFHTSMVTNGWRLEKKINEIHTSLDFLFVSIDGSKEVHDTMRGMQGSFEHAVRGINASKHMVPVAMSSTITRENIDSIGDILDLGDKLEVPINFQIEYDYSTAEKISPEKEKLLGALNMLIDRKKADGPIMNTVQYFEAIRDSWFYGYKWECRPWLTINIDPEGRVVTPCYIINEYSGSDYVWNIDIKKMWNTFDWEPYRTCNKCALSCYLEPSLFKWTRPAMVKSRIIDATIDYIKFSASKRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N282</accession>
    <name>A0A1V0N282_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine-S-conjugate beta-lyase</fullName>
            <ecNumber evidence="2">4.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141449.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N282"/>
    <dbReference type="STRING" id="74969.FAD_0279"/>
    <dbReference type="GeneID" id="31675788"/>
    <dbReference type="KEGG" id="fai:FAD_0279"/>
    <dbReference type="OrthoDB" id="43458at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000046">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000033">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="381" mass="42318" checksum="574E7068318C95FE" modified="2017-06-07" version="1">MNSNGFNSRCVHSGDMEIEGVGNVVTPIFENSTFEFPESGVAGKYIYSRWGNPTVESFEKKYADLEKTEHAFAFSTGMAAITSSIMPYLKSGDSVLALNELYGQTFGFFSKVLPQYKINVDFTSVNDLNRLNFKNKNYKLLYLESITNPLLEVPDIVNLSRICKEEGIKLMVDATFATPYNQNPVSLGADMALHSGTKYISGHSDLLIGLAGFNDNYDNLDFYRKTFGGTPDAFQAFLAYRGLKTLGLRMERHNKNAMELAKVLNESSRIEEVYYPGLKNSEYFDVAEKNLKGYGGMVSFKVKGGIENSHKLIKNLNIPKYAVSLGGVESLISIPVEGTHKALSPEERKASGITDNLVRLSVGIEDSEDLLQDFENALEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2A7</accession>
    <name>A0A1V0N2A7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur cluster-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141487.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2A7"/>
    <dbReference type="STRING" id="74969.FAD_0315"/>
    <dbReference type="GeneID" id="31675824"/>
    <dbReference type="KEGG" id="fai:FAD_0315"/>
    <dbReference type="OrthoDB" id="23833at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="LutB/LldF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="LACTATE UTILIZATION PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153:SF2">
        <property type="entry name" value="LACTATE UTILIZATION PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="378" mass="42287" checksum="0C17EABBE29595C3" modified="2017-06-07" version="1">MNYEWDVAVNKAIVNNAPRVQQILDDNPYIKDVASELRKTKNTVLDNIESYISKTEESVKRTGGHFHYAKDSSEAMDIVREILGEKSKIVLSKSNVLYEIKLREELEKEGKDIWETDLGEYLVQINNDMPSHLVAPAIHLTKDKIGKLLHENLDSTINENTSPEEMVSRVRKFLMEKYLGAEVGITGANAIAADTGSVLLIENEGNIRMDTVLPQVHIAITGIDKIVPTLKDAFNEVIVQASYAGFYPPAYINVTSGPSATGDIELKHVSPATGPKEFHLIVLDNGRKEAIDSDIRESLLCIRCGRCYFSCPSYKLYGKDFGDSPYTGPTGIMWSAITMKKYDKSMLCMHSGGCREVCPMDINIPQVIEKIKFRYIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2B1</accession>
    <name>A0A1V0N2B1_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Sulfide dehydrogenase (Flavocytochrome C)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0342</name>
        <name evidence="3" type="ORF">HLB00_01435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000040">
        <property type="protein sequence ID" value="NOL59500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141515.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2B1"/>
    <dbReference type="STRING" id="74969.FAD_0342"/>
    <dbReference type="GeneID" id="31675851"/>
    <dbReference type="KEGG" id="fai:FAD_0342"/>
    <dbReference type="OrthoDB" id="38899at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052541">
        <property type="entry name" value="SQRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43755:SF1">
        <property type="entry name" value="FAD-DEPENDENT PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="377" mass="41860" checksum="E3BE001CED6CBCC8" modified="2017-06-07" version="1">MDTTNVLIIGDANAGIITANKLRMHTGKDVNITIIGNSEKTYFKPEGVLIPFNGIDYRDSIKPTDFLINYGIKRIKAMATRIDPANRSVVLDNGQKLTYDYLVIATGDRLVPEDVPGYNPDVYHFYDIENVLRLKKMLRGFKGGKIVVGPASTPFQCPVAPGEFMFGLDLLLRNKGIRENSELSLIVPMKDVLPFKSVSDFVRKGFEEYNINFIPDFKTEYIEPEKNSIVSSSGESLQYDKLVLIPPHRGQKFLSDSGMAGDSGYVDVDKFTLEYSDYDNVFAVGDAANFPMKVGALGHSEAAYVAERIASESDGVISDTKFDGFMGCSSIYAEQRGFTLSFDYNSKPSVNFASAPDYFLKYISGDTYFSSIIRGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2C0</accession>
    <name>A0A1V0N2C0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141554.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2C0"/>
    <dbReference type="STRING" id="74969.FAD_0379"/>
    <dbReference type="GeneID" id="84218877"/>
    <dbReference type="KEGG" id="fai:FAD_0379"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="123" mass="13424" checksum="F9881AF5B91669E2" modified="2017-06-07" version="1">MIILFDLIALLIAIVILSIPMYVASKIVVSGRNSSFGKAIAATILTVIILVFLSLGLHVLFAPLAVAGSIIAFLITLFILLYTYSAIYDISLGRSFILAVMEIIMWFLFFLFTGILGAFFALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2C3</accession>
    <name>A0A1V0N2C3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2-type family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887340.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2C3"/>
    <dbReference type="STRING" id="74969.FAD_0322"/>
    <dbReference type="GeneID" id="16025486"/>
    <dbReference type="KEGG" id="fai:FAD_0322"/>
    <dbReference type="OrthoDB" id="56719at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37305">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37305:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="278" mass="30072" checksum="9189AB0804ED50EB" modified="2017-06-07" version="1">MENDSDANQYMISLKYQFKSYLRTKRFLGLILFTTIISIGITALMLHDEYSMLKAGTPLLYFYKYLSGFSADLVVIIGAFFGGDIISTDTGTNAAYYTLVQPVRRSILFVGRFTAALISSFIIVLVYFVVGVGSSLYLYGKVTPVIFESLGILVLFLAAAIAFASLFSGIFKGQSSGIIVSVLLLFIGFPIIDEFVGSIGGIDPLFSLNFAGEIMYLIFEKPYPAVKASGSGFGPGAGAGAFYTFSPTVMQGLGVLIAYIIICGIIAIILYSRRQIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2D4</accession>
    <name>A0A1V0N2D4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141553.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2D4"/>
    <dbReference type="STRING" id="74969.FAD_0377"/>
    <dbReference type="GeneID" id="31675886"/>
    <dbReference type="KEGG" id="fai:FAD_0377"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052962">
        <property type="entry name" value="AA_Transporter_AGT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47547:SF1">
        <property type="entry name" value="ASPARTATE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="531" mass="57594" checksum="7A7AF80C935248B2" modified="2017-06-07" version="1">MVDIETQNNVVKSKYKKDLGLWSVIMLALGGILGPAVAYAPVYTLAYAGPIGILAWPIAMVMIIPIGLVYAELGTTWPKAGGVAYYPSKSNGPIVGAINGWSSMVGYLFVGPVIVFAVVEYLSFYFPSLYANGTLTYLGIIVAEIVLILVFLVNILRIKHMGAINLILTAITLLLIGVVIIALAFYFKLSNITSTAGGVIPYGFTGFFGAITLTVFGYGGFRQPIDYSEEVKNPGKSIPIAIIVALLVSGLVFSLESLVFAGAINFSKLGISTGNWSALFAYSSPYATLSKVLVLPAIVIIAIIVALIATFKDGVIYYGGTARVGEVLAREDKFLPKLFDRMNVRGIPVYSIVLVLIITIVLVALGRSLATIIGIMVDGFLLSYAPGAISLMVFRKTDIVTKRPFKLPFAKILAPIAFIVANLLVYWSGWAAVEIIIPLDFAGILLVLVYSHYTKIDMKYAMYGIWMPVYLIFILIMSRIGSSLFHGLNYIAFPYDTIVFIIVTMVFYFVGVNLGVKSVNYITNKKAGNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2G0</accession>
    <name>A0A1V0N2G0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Lipid exporter family ATPase and permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_0413</name>
        <name evidence="13" type="ORF">HLB00_05000</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141578.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2G0"/>
    <dbReference type="STRING" id="74969.FAD_0413"/>
    <dbReference type="GeneID" id="84218924"/>
    <dbReference type="KEGG" id="fai:FAD_0413"/>
    <dbReference type="OrthoDB" id="57432at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000221">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="330"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL60193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="570" mass="64078" checksum="206C81D9DDD15F09" modified="2017-06-07" version="1">MNRYSIIFKNIKSVWYLIIVVIGASLAYAYLRLLVPLYIGDAVNNLVGKNYIIILHFALLIFGVTVASSIFDFAIDYYANKASQKFVYNLRKNEFSHLLAKNYEYFNSNSTGNILSKFTMDIETLRRLVNMSLSNLFSVTFLIIIAGIDLTRLYYGFTVIFFVVIAPIIYFTLVMQRKQRKYWRALRDKYGTMNNLINQNIIGNRVVRSFTAEEEEIKRFNNSTDSYFDDYKGIAGVRSLYNPLLALFLSLAIGFVLIYGGIESIDSIISVGSVIAAVNIFTLVLRPVRFYGRYISFYENGMASLDRINAINNDNSDYKGTLLPEVYGRISLENLGYKSNNSTILTGINMDIAPGERVAIVGETGAGKTTLVNIISGLYKNYTGHAYLDGTELKEIDDKLIREKIGIVSQDAILFSGTIRYNITMGKDYTDDQVRNAAKLSMLDDFIDSLPSGYDTPVGERGITLSGGQKQRMAIARIIIRNPQIIIFDDSTSNLDADTETRFLNTIQGFIAGKTTIIISHKISSVMLAERAYVIEKGRVTEYGYIKDLIKSNGSFSDIFAGKFRGDAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2H0</accession>
    <name>A0A1V0N2H0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminopeptidase P family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Xaa-Pro dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0409</name>
        <name evidence="7" type="ORF">HLB00_05020</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887441.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2H0"/>
    <dbReference type="STRING" id="74969.FAD_0409"/>
    <dbReference type="GeneID" id="16025587"/>
    <dbReference type="KEGG" id="fai:FAD_0409"/>
    <dbReference type="OrthoDB" id="1346at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01092">
        <property type="entry name" value="APP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="140"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="357" mass="39755" checksum="4456A2F96E5439A2" modified="2017-06-07" version="1">MKERKIFDYVRNVDSVLIMNGGENQVDKTFFYLTGAKSGIFEGSLLHVKPEKVTIITSALEEEAAKETGFEVLIYNTTAEKNEIIKNAFKNDVNVGLNYSALTLDLYKQLMKIIPDKEFIDVSQSIAESRKIKDESELKDLREAAKIASDSFEDFTKTLKEGMTESELAANIVYAMMKNGASGESFSTIVAFGKNSAIPHYMPGNAKLKKNDFVLTDYGALYHRYCSDTTRTVVFGRADEKQKDIYETVKRAQQESKNALKAGVNGKDIDMIARKIIDEKYPGRFIHGLGHGVGMDVHDHPALSPSSDFILKANMVITDEPGIYIPGFGGVRIEDDLIIKDGGHEEITTAPRELLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2I4</accession>
    <name>A0A1V0N2I4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Cytochrome B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">soxC</name>
        <name evidence="12" type="ORF">FAD_0385</name>
        <name evidence="13" type="ORF">HLB00_00605</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000016">
        <property type="protein sequence ID" value="NOL59339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141558.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2I4"/>
    <dbReference type="STRING" id="74969.FAD_0385"/>
    <dbReference type="GeneID" id="31675893"/>
    <dbReference type="KEGG" id="fai:FAD_0385"/>
    <dbReference type="OrthoDB" id="55795at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271:SF16">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="Transmembrane di-heme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b/b6 N-terminal region profile" evidence="11">
        <location>
            <begin position="11"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL59339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="397" mass="45044" checksum="796ADC511E1992D2" modified="2017-06-07" version="1">MEKAETNNYNITDLVKEEKDLPEGSYKIGFKSVTSRGYRIDEWTGSWVATALIYQIVSGIVLFFYYSQVDPYHSTQYIISDVPFGHIILTSHLYMAYAMIGLVYFHMMRQWFVGSYRGKWRWLQWILGVVLFLLTIFTAILGYMLANTAIAMAAVHIGILFMQRSVLGRILPGALINWLEAILVGNYTTPALFSHLLALHVAVFSTLMLAIFAIHFMLFERSGLASEKPKKGEMIPWFPTNLLYAVFSGIVMVGVILIISAAFPQQLTLAYGSLAYGTFPVPDWYITPVYKLMDVAGYGLSTGGVPLIIGMLVFILLLPFIDRYHNKGVLERPWITAFGIFMLIGLAVMTVWGYSQPGLTQTRLMTMYLWWSITFISFITVYAMRFAKRDGELSENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2J1</accession>
    <name>A0A1V0N2J1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141565.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2J1"/>
    <dbReference type="STRING" id="74969.FAD_0393"/>
    <dbReference type="GeneID" id="31675902"/>
    <dbReference type="KEGG" id="fai:FAD_0393"/>
    <dbReference type="OrthoDB" id="39225at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="105"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="311" mass="34942" checksum="53FD8F023E8D86E5" modified="2017-06-07" version="1">MNCETIDWLNKHSGKYELSHSGMSGVFDLKEYFNKSTPGHETDLKEQIGDLHGVDAKNVVLTHGATEAFSMVLYHLHAKYNTFIVNKPEYEMIYKTPEIFGYKEGNELFVASNPNNPTGTLIKFPDKYSSCLIDETFMEFVEKLDKYRYTNGYIVNTFTKVYGGGDLRLGYIIAPDKDEAAKLEGFKGLITEDVSWINVSAGYEILKKHDELLANVKEIINSNHKVLIHEKGKLKFYSGKDPLAMPVSFVDYSGYTAEGSESVSEKLAKKGIIALPAKYFGITGPYLRVCITGKDFPEAYRALLNALEGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2N6</accession>
    <name>A0A1V0N2N6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="5" type="ORF">FAD_0435</name>
        <name evidence="6" type="ORF">HLB00_06935</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000248">
        <property type="protein sequence ID" value="NOL60563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841680.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2N6"/>
    <dbReference type="STRING" id="74969.FAD_0435"/>
    <dbReference type="GeneID" id="16025637"/>
    <dbReference type="KEGG" id="fai:FAD_0435"/>
    <dbReference type="OrthoDB" id="14749at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002222">
        <property type="entry name" value="PRK01115.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="246" mass="27422" checksum="3848A9D886943E00" modified="2017-06-07" version="1">MTRMNISVKNLRDVVDMLGTVVTEAKFKIGQQGISVNAVDPAHVAMVSLEIPKGILLEYDVESEEELSLDLEKVKGILKLASGNDSFIITKDKEKLRFEIGNIIKSISLLDNSQISTPRVPQIVAEDYIVINKGDLEKGLKAAEDVSDAIRFTMNPDSFSAKSMSDADESEMILPGDKLKEIQCHESIKSSYPLEYLLKFMRSISPNEEVKLSFKSDYPLTIEFNLGSESADRIKGRFLLAPRMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Q3</accession>
    <name>A0A1V0N2Q3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rnz</name>
        <name evidence="10" type="ORF">FAD_0441</name>
        <name evidence="11" type="ORF">HLB00_03825</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000124">
        <property type="protein sequence ID" value="NOL59961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Q3"/>
    <dbReference type="STRING" id="74969.FAD_0441"/>
    <dbReference type="KEGG" id="fai:FAD_0441"/>
    <dbReference type="OrthoDB" id="85118at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000801">
        <property type="entry name" value="PRK00055.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="9">
        <location>
            <begin position="201"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL59961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="312" mass="34857" checksum="527C225B81E0B0A0" modified="2017-06-07" version="1">MNMASNIRITFLGTGGSMPKPGRSLPAVAIQVDDILNLFDCGEGTQKQFMKSGVSFMSLSNIFISHFHADHFLGLPGLLNSLSFMGRTEDLNIFGPVGAVNFIRNAITLGYGRISYNINVVEVIPGTSYNLGKFTIRTLANNHTVPSISYSLEEKDLTKIDRKKVDEIGFPVYRLEELRKNGKVELNGKEYLLNDVAMGIKKGRKIVYTGDTRPVPEMPEFAKNADVLIHDTTMDSSMEPMVNEYGHSSARQAAESALKGGVKKLFLFHYSSRYNDLDILLKDAKKVFPESYLSHELEQYDIEKNDRLISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2W8</accession>
    <name>A0A1V0N2W8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0525</name>
        <name evidence="4" type="ORF">HLB00_00575</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000014">
        <property type="protein sequence ID" value="NOL59334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887583.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2W8"/>
    <dbReference type="STRING" id="74969.FAD_0525"/>
    <dbReference type="GeneID" id="16025729"/>
    <dbReference type="KEGG" id="fai:FAD_0525"/>
    <dbReference type="OrthoDB" id="56581at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="1,4-DIHYDROXY-6-NAPHTOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167:SF1">
        <property type="entry name" value="1,4-DIHYDROXY-6-NAPHTOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="288" mass="32641" checksum="1B301B635B9D447A" modified="2017-06-07" version="1">MKTLKIGALADSGDLYPFIPLLEKKVKSDDFNLEFEFIPTVQEVNDKIVKKDVDISVPSAALYPYIQNDYFILSSAVASAVDGITGMPILAMKKMDIDEIKNSKIIVHGLNTTAFNLYKLLIGKYKKLIVVHRVLDEVNSMVNEDGVMVAVHELKAMYDLRKMGVEPVRLASMWEMWKQLSGNRPMPMGTVVINSEIGEEYALKFKELYNKSKKYAESHMEEILPVDVKIMREVQNSDISLEVIKGTIGADVKEYNVSIDDVKSGLEFFYEIMHKKNLLPGVKELRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2X9</accession>
    <name>A0A1V0N2X9_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">Cationic amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951095.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2X9"/>
    <dbReference type="STRING" id="74969.FAD_0539"/>
    <dbReference type="GeneID" id="31676045"/>
    <dbReference type="KEGG" id="fai:FAD_0539"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="18"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="465" mass="50016" checksum="AF3DC1A87FE94EDC" modified="2017-06-07" version="1">MDQLKKNNGGFWLALFQSMAFVAPAASVASFFTTGVAAIGGSLPLTYIIATFGVLSAMYMDYSFAKRISHAGGYYAFVRSGLGNKLGTLSAWFYLYDMIAAIAGFSTLYFGAIVAPYIPFLNTSPYGWLPLSLIPFAIIFFFLWNGLRPSLWYTLISSVAEISFLVIGAIIIIILLGSKNTLAPFTLTGHPISALGLATVYSVLSFVGAGSVIALSEEIKNPRKNIPKALVIVALLAAAVYILASYAVVVGWGLSNISSFATSTNPGITVYARYLGPVGLVIFVVLVANSFISNGIAQGNAGSRTAYSMARDNILFSSRWAKVNERTGAPRMVIGIMIIVTFILMIVFGLIFGPFEGGTILITAEAALLYIIHILGDISLPIYAKRKLKYRLKAYLPLLLGPLPATIVYAVAEYGVFIPIPAYPNSIYVYGTLALIGVGIVLAITIRHKPVHVDQSVFEQEAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N340</accession>
    <name>A0A1V0N340_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0647</name>
        <name evidence="5" type="ORF">HLB00_03620</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000115">
        <property type="protein sequence ID" value="NOL59922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141747.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N340"/>
    <dbReference type="STRING" id="74969.FAD_0647"/>
    <dbReference type="GeneID" id="84217249"/>
    <dbReference type="KEGG" id="fai:FAD_0647"/>
    <dbReference type="OrthoDB" id="57181at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420:SF12">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="169"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="305" mass="35999" checksum="3522DD7EB155531C" modified="2017-06-07" version="1">MKLDNYRLNWEVILKKEIDFLSKKYPDLDIKGSYSSVIELLNENKIRYRIIMHKNELVGYAYIMDSTDKSDRLYADIGFTSPKKITEDRLKEIFEWLTGIASKEKKKLMLNPIINGNETSEKYLTDSGFKTIVRKRMVMDLNDYKYNKLDEKYDISGIDDINMDLYSDAEYEAFKYTSDKFLFSNKREDRLQTVVNLFKGEYGEIIKEVTVIIKNKGRISGAVVSSRLGFDRAFIVSIFVKRAYRKTGMGKYLLFTALNRLKALSYHYVFLWVNAENFAKDFYLHYGFKYDDYPDEVIYYLPNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N385</accession>
    <name>A0A1V0N385_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase, subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N385"/>
    <dbReference type="STRING" id="74969.FAD_0714"/>
    <dbReference type="GeneID" id="84217337"/>
    <dbReference type="KEGG" id="fai:FAD_0714"/>
    <dbReference type="OrthoDB" id="57106at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="120" mass="13732" checksum="C05B6F28D026CA33" modified="2017-06-07" version="1">MNYDDLLKGTEITGKSEIPPRPGEAPFATEIYYKKDDLFYGKLHVRKLNNAMYLSVISKIPFNWKQLVGDMKFSGTMVDSAGGLLWLKESEKTLAQDLAYIEQYLTDMKNKDAKNKDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3B9</accession>
    <name>A0A1V0N3B9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YdbS-like PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0656</name>
        <name evidence="4" type="ORF">HLB00_09905</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000440">
        <property type="protein sequence ID" value="NOL61131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141756.1">
        <property type="nucleotide sequence ID" value="NZ_CP133600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3B9"/>
    <dbReference type="STRING" id="74969.FAD_0656"/>
    <dbReference type="GeneID" id="84217258"/>
    <dbReference type="KEGG" id="fai:FAD_0656"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="YdbS-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="YdbS-like PH" evidence="2">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL61131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="140" mass="16613" checksum="97D1E7F7D356F9C4" modified="2017-06-07" version="1">MLAVWIRGMEKTLIKITILVVIFSVFLRINNKTILNYLIFLGVVYLVSILYILYKMSYKVEIYEDHLYIKNFFASHIVKYQNIKDFFITEGYLQRKFGLHSIYIITKTKNYLLKDLPDAEKIHDDIQIQLNNNNIGIKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3G1</accession>
    <name>A0A1V0N3G1_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0711</name>
        <name evidence="2" type="ORF">HLB00_07240</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ARD84617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141824.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3G1"/>
    <dbReference type="STRING" id="74969.FAD_0711"/>
    <dbReference type="GeneID" id="84217334"/>
    <dbReference type="KEGG" id="fai:FAD_0711"/>
    <dbReference type="OrthoDB" id="55517at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="94" mass="10975" checksum="298CF63CB77AFFBD" modified="2017-06-07" version="1">MKPNINFETLKNYVMENSSYRLYTDGDKFDLHFVPNAPEAEAHFPEGESVEHVMYGYIEDGVAYFTKFVTISAFGKTEMDMIDDDPVMEWLKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3H1</accession>
    <name>A0A1V0N3H1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
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                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="ARD84641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3H1"/>
    <dbReference type="STRING" id="74969.FAD_0737"/>
    <dbReference type="GeneID" id="84217360"/>
    <dbReference type="KEGG" id="fai:FAD_0737"/>
    <dbReference type="OrthoDB" id="7442at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="261" mass="27389" checksum="064F0A1142181412" modified="2017-06-07" version="1">MGKIDLTGKVAIVTGASGGIGKAIAISLASAGASVAVHFGRNKNAADEVVDKIVAAKGKAIAVSADMADPAAVEEMFRKVDSSLGTVDILVNSAGIDGVRAMLGDDDIENWKKVISVNLYGPYFCSRMAIQRMKKKNKGVIINITSDHVNIPWQGYSAYCSSKAGLDMMAKTLAQETATMGIRVISIAPGAIKTAINKSVWENPDTLKDLDEKIAMGFPGDAEDVADAVLFAASDMAKYITGTTIVVDGGMLIYPDFRHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3H4</accession>
    <name>A0A1V0N3H4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily multidrug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141991.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3H4"/>
    <dbReference type="STRING" id="74969.FAD_0801"/>
    <dbReference type="GeneID" id="31676303"/>
    <dbReference type="KEGG" id="fai:FAD_0801"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17504">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF192">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="14"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="477" mass="52059" checksum="06BD6B7C4B81857C" modified="2017-06-07" version="1">MSEIKMSKRSINITIALMAFSGLLIIYVETMIVPAIPVFITFFHSTYSNVSWILTAYIITGTVSAAIFGKVADIVGKKKVFLLLGIIYTIAISFGGFAHTLDELIAVRAVQGIGFGMIPIAFAIINDVVPREKLALAQGIMSATFAIGSGIGLVLGSYITETLGWQWDFHTAIPVAIILLILTYIFIRENTVTGKQKIDFAGVSMLGAGLVLLIFGLSEGEHYGWYSHLIIGMFILAFILFAAFTYFESHYKYAFINMKLLKKRNIFLSNIVGLFAMAAMYFLFFTVPTLLQDPSPIGFGKTVFYSGLILFPATIMNMIFAPVAAKIIKHRGPRLSIIIGLSVDIIGFGLLYLYRATIPEILLDTMFVGAGISLMLVGIINVLLTSTPRANAGEATGMNTVFRDIGMSIAPAVGGALETMYTIKVTVGVQIINGIPTKIQQAFPDSTAYNYIYLIGVVFVILGFIFTAFMKKTKIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3H6</accession>
    <name>A0A1V0N3H6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141930.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3H6"/>
    <dbReference type="GeneID" id="84217380"/>
    <dbReference type="KEGG" id="fai:FAD_0760"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="426" mass="48439" checksum="60F06C7867C6BEC0" modified="2017-06-07" version="1">MAWYEVINGSADSVYNKKLYSIMGQKFGLFYFNKENRIHIFLNTNTRYSFIKQSVELDPIDAMPVMNHYFVSESRKEKDYYDTGVEFTNIRDVIEKLADGQGMMFWFLYYNQKPDKDQYVLQEDKYLVKIIFMQRNDKYMKKKPDEDLNNVILGKIQDCIRADINWKEIKGKKYSLYSGNFRKPLLVGNKKILYTYKAKIEDFLELDYSMKEPKLAAPQQTAQEFIDFQRDESPTGMILDTKTEAINAIASGEKTTLITGPAGDGKIGLAAKIMSGAEKTGREIAILNTGKFDPFKSIINGNSSFSIKRFDISQEYYDQRIVDSAADAAALASKLWAAIVTGTESLRNPLIVINSANDIVPLSPGGVPAYENELWGSFFKYYDAGSNGMGIIFLKDGNQDALRLYTDYILKASNESEGNGFEIIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3I4</accession>
    <name>A0A1V0N3I4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3I4"/>
    <dbReference type="KEGG" id="fai:FAD_0820"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="48" mass="5816" checksum="10B1B6760CB006A4" modified="2017-06-07" version="1">MYIKIFLSSFPDDYEISNCRDLPYLVVYFIKYAIVAIFNFSIGKWRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3I7</accession>
    <name>A0A1V0N3I7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3I7"/>
    <dbReference type="KEGG" id="fai:FAD_0770"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="62" mass="7138" checksum="E14E367A934C6808" modified="2017-06-07" version="1">MCRILCKLHIKAVSLHFQIYWHGNPLRERSAIGRLTAGNNPYQSFQMITLPSPVEQPKTQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3K1</accession>
    <name>A0A1V0N3K1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3K1"/>
    <dbReference type="KEGG" id="fai:FAD_0767"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="132" mass="15015" checksum="131BFB3DD143067D" modified="2017-06-07" version="1">MDSFENEAKKNYDKIGEDFPRGSIKILSPDIINILITNARKSKTVNYKAGDTVYTATFSSYTLLDKDGMVGVYSDVPEDTNIREITFIVTGFHAKWDTEVTFSGEYMTVMPDRELKHLVNFQRAIMKTGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3K5</accession>
    <name>A0A1V0N3K5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3K5"/>
    <dbReference type="STRING" id="74969.FAD_0771"/>
    <dbReference type="KEGG" id="fai:FAD_0771"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051685">
        <property type="entry name" value="Ycf3/AcsC/BcsC/TPR_MFPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943">
        <property type="entry name" value="CELLULOSE SYNTHASE OPERON PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943:SF8">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN MJ0263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="536" mass="61622" checksum="E758F97454E25602" modified="2017-06-07" version="1">MAAWTNNTICNDTKNNIYYSYSFGMPNKSIQPAASKNMEKAIGLMENYDYSDAKKRIDMALALDPLNYEYHYIKVNLLIERRDYEGALKELHVMEKLVPDKASVYSLESRCLINLGKNFDAVGKADEALEHDRNYMQAYENKLIALQNIGLINDAFDVYYSALKVDPQDAESYAVLSELHMEMKNFDAAHESAKKAINIEKDNIKANNMLVSIARVDGGIEDYIKALSDAYVNTHYEGYIVQLTNCLYESGNREDAVKIAEKFYKINPGNMNSAHNLAHIFILENRIQDAGKVYKNSIKLNKSEFTNLQYITFLNETEQYATVLKNVDELIERYPDNDGFLYNKFYALSRSGDHKDALIIIKLLYGQNKDSILYKVEYALELALTGNSDESLRILENFEELYIDPWISMSLWSLYSMLNQYDRANEYAILAMENGIGDEFLGSFPLEVIETYLEKGWKIQAIKFIDALIERAEGELQDICIACKGCILGIDDYDKGRDILEQIGSAEKIRYLLLFKLKFTDVEINNFINRYKNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3M0</accession>
    <name>A0A1V0N3M0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3M0"/>
    <dbReference type="STRING" id="74969.FAD_0773"/>
    <dbReference type="KEGG" id="fai:FAD_0773"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051169">
        <property type="entry name" value="NADH-Q_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42913:SF3">
        <property type="entry name" value="64 KDA MITOCHONDRIAL NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42913">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="64"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="341" mass="37645" checksum="04B4CA359451A387" modified="2017-06-07" version="1">MIKGFNRMAKQIYVLGGGLSGIYAKLTNPDAMLIDRDDHITISTRLITLIGGMENSYAYKPRNIDLKENVKDINFENREIVTDNGKHEYSKLIIALGHSFNVNNIKGSTNIAKLETIDDAVNIRKRLQTSKNVAIIGGGYLGVEIASLINGKKVTIIDPHDRLLNHSSPEASEYVNNMLLARNVNITKGTKVMEVTGKSVITDNEEITSDLTIYAGGIYGNSIISGLPIKTKNSKILVNSKMRSLSYDDVFACGDSMAIDGKSFPATAFTGRKSAVVAMKNAMGNDIEFKYENNGNILNIDNNYIFVKKNGYRKSFMVNLIKKYVNGKTDKSLNKLARLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3N1</accession>
    <name>A0A1V0N3N1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide pyrophosphatase/phosphodiesterase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141989.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3N1"/>
    <dbReference type="STRING" id="74969.FAD_0800"/>
    <dbReference type="GeneID" id="84217420"/>
    <dbReference type="KEGG" id="fai:FAD_0800"/>
    <dbReference type="OrthoDB" id="33550at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="366" mass="41394" checksum="26F9A5CD5BC48351" modified="2017-06-07" version="1">MDKNFILPEEKTLVNLSSDIFGHFGLRTESEGIGLNYKNKKLCFILLDGLGWNIYRQTGIEFKNEIKGTSVFPSTTSNALSSFFLNKFPGQHGIIGYQLYIKQLGSIVNILGYTSSAAYMRDSMEKAYPMSSIFNFESKVTSLNRAGYSTVNIIPGFINKTSFSNILYGDNTTDTYANMVHSFYVLEENLKQGRDFISYYAADVDQIAHKLGPNNPYTIENARYILQQLSMIMKKYPEYDYVITADHGHVEVGNTINLGNDSGLRDISILPPYGDSRALFLENRKDIKDYLEEHYTNLELVEKGSQNYYQLLGKVDANTLSNLPGVIGIAKNNDIYHFPLNQRKYTMKGAHSGLLKEEMEIPVLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3R0</accession>
    <name>A0A1V0N3R0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nicotinate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142032.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3R0"/>
    <dbReference type="STRING" id="74969.FAD_0829"/>
    <dbReference type="GeneID" id="31676330"/>
    <dbReference type="KEGG" id="fai:FAD_0829"/>
    <dbReference type="OrthoDB" id="371831at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01571">
        <property type="entry name" value="NAPRTase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053190">
        <property type="entry name" value="NAPRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035809">
        <property type="entry name" value="NAPRTase_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006415">
        <property type="entry name" value="PRK08662.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43202:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43202">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="2">
        <location>
            <begin position="129"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="386" mass="42804" checksum="A01A4256004A875F" modified="2017-06-07" version="1">MNRFTMANDSDIMNGAVTDVYFEKTMEYLTMLKKNPYVTMEVTTQSSAYEYINFTGLNDVLPLLESHNVDVYAIPEGTVLKPRDINGIPVPFLRISGKYLDFAELETPLLGFLCQASGISSYSSLLKKSLGNIPFISFGIRRMHPAISPMIDRSSYIAGAAGVSGVLSSKLLGIKPSGTMPHALSLILGDHDAWKVQHDNSDFRVFLIDTFMDEKFAAIKAAEEFPDIDFIRLDTPSSRRGNFPNLIREIRWELDIRGHKNIKIMVSGGIKLEDIPELLSAGVESFGIGTSISSAKPVDFGMDIVNIDGTDITKRGKFSGIKNVYRCKTCNDVIAGYSDTKPTCHCGGTMENILQPYMENGKIIKNEDIETVRQRSLAQIENVMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3T2</accession>
    <name>A0A1V0N3T2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mercuric reductase</fullName>
            <ecNumber evidence="4">1.16.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Hg(II) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FAD_0911</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Hg + NADP(+) + H(+) = Hg(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23856"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16170"/>
            <dbReference type="ChEBI" id="CHEBI:16793"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142171.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3T2"/>
    <dbReference type="STRING" id="74969.FAD_0911"/>
    <dbReference type="GeneID" id="31676414"/>
    <dbReference type="KEGG" id="fai:FAD_0911"/>
    <dbReference type="OrthoDB" id="27922at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016152">
        <property type="term" value="F:mercury (II) reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045340">
        <property type="term" value="F:mercury ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050787">
        <property type="term" value="P:detoxification of mercury ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021179">
        <property type="entry name" value="Mercury_reductase_MerA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02053">
        <property type="entry name" value="MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014:SF4">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE RCLA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0475">Mercuric resistance</keyword>
    <keyword evidence="11" id="KW-0476">Mercury</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14 17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="19">
        <location>
            <begin position="4"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="18">
        <location>
            <begin position="337"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ARD84803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="460" mass="50222" checksum="9C617CEEB2C4B63E" modified="2017-06-07" version="1">MTEYDLAIIGWGAAGFAAAIKASELTSNQMKIALIGTGELGGTCVNVGCVPSKFLIEASKNYKEAKSPAYAGITSSATIDFSEFMESLNKFVSGERETKYTNVMKNFENIELIDGLAKFVDNNTISVNNTEIKATNFIIATGSRTFIPEIRGLTDYYTSDTVWEMRKLPGKLAVIGSGEVALELAYAFSNFGSEVHIFNRSNRILKGFDDDVNSQLTAALKSNGIVFHLGVNFYEIKNEDGKKDIVTWTGTFGDFDEIIVATGRMPNIDGLDLRAGGITADNGIVVNPDFRTTNPKIYAAGDCVRQSLKLETLAGKEGVIAVENILGGNRKINMQEVPWVVFTEPNVASVGYTEAELKKKHIEYDVRIVELKNVVKANILNSYTGIAKIISGKDKKILGIHVIAPMAAEFITEGVYLIKNGLTYDDLIDTIHVFPTVAESIKITGQAFIRDISKMSCCMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3U2</accession>
    <name>A0A1V0N3U2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142088.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3U2"/>
    <dbReference type="STRING" id="74969.FAD_0865"/>
    <dbReference type="GeneID" id="31676368"/>
    <dbReference type="KEGG" id="fai:FAD_0865"/>
    <dbReference type="OrthoDB" id="136106at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614:SF2">
        <property type="entry name" value="TRANSPOSASE IS4-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="190"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="453" mass="52967" checksum="763A924DDD8F3C0F" modified="2017-06-07" version="1">MTREIKKVGKYNYVYESSMVWDSEHSKRHKVSKYVGKVINGDIENPKKVREVVSIHGIYEIGHLELIFSLMKDVLSLLREEYPDDYMKIVAFSLNRLIFPLPLKYIKSWIEKTWLSRTIHELSPESLSSMLKRIGQNQDKQKSIYMKLMKRNEIIAYDTSALFSYSPGIRMAGFGHNNNDLNLPMIRTIMGFSRLRNEPCYIRLVLGSVADIDTLRKTEEELSPGTLFVMDRGFIDDNNFGKMDLNGLYFITPLKRDSKLPDYSINSNNFFMFRKRAIKYTSMTVKNYDIHVFEDILLRAMEENEYYSLIDSGKKPLYSPEKAGKIALITNVREKPQSIFELYKFRNDIEESFDVFKNLLQVDTPYIRDDDTLKGYVFVSFISLIAYYRLLKLLKEKKINNKISVKDALLQLSKIYLTDVGDRIIMAEIPKKVRELAEILELKPELFPKNVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3V2</accession>
    <name>A0A1V0N3V2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3V2"/>
    <dbReference type="STRING" id="74969.FAD_0891"/>
    <dbReference type="KEGG" id="fai:FAD_0891"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="190" mass="21993" checksum="36A68DB5560DFA38" modified="2017-06-07" version="1">MLLDSTTYISNEIMSNNYYDIKINNKGNLLTFDFKKESSKWLYGESDVEMGITDNNSLAYISIEIKNGLTTQELKLLKKVIKNEDNKYNVQDSGSINTINSFLTVAYDYPNFNDKRDYYAIKINNKGNLLTFDFKKESSKWLYGESDVEMGITDNNSLAYISIEIKNGLTTQELKLLKKVIKNEEIKFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3W4</accession>
    <name>A0A1V0N3W4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142123.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3W4"/>
    <dbReference type="GeneID" id="31676390"/>
    <dbReference type="KEGG" id="fai:FAD_0885"/>
    <dbReference type="OrthoDB" id="58081at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="273" mass="31781" checksum="4EECC65F027D84DB" modified="2017-06-07" version="1">MTENKIESDYLLSRINEMFKIVDISNKIVSAKNEEKAKQVHVLWDFDRVPIEDKDGNIKEYYDSNEDKIVQIIPADLVSESTGILKTLSSLYPNKFYFVLTGNKITHIVHYSDLNNPIVLPGIYTLIAYCEIKIREYAREKNTYGNADSDIEKLLTDINTRSSIKINISRAKSYLIKKMRAKIETNLLDELDFDDELILFRELSLMLNDERFKEFKKCVVLSDNTIKSYYALRNDIMHSNYQMIEKQSHDIEELGAFINACQKLISYIESISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3X1</accession>
    <name>A0A1V0N3X1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951113.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3X1"/>
    <dbReference type="GeneID" id="31676386"/>
    <dbReference type="KEGG" id="fai:FAD_0882"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="69" mass="7701" checksum="599A0DF6B695C72A" modified="2017-06-07" version="1">MGILKNIKEHTKKEAVNNYSVSDVNKIVTLLLNANSVKIRNKPKMGEQCVPSVDLITGKLVYQCTVDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3X6</accession>
    <name>A0A1V0N3X6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3X6"/>
    <dbReference type="KEGG" id="fai:FAD_0966"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.620">
        <property type="entry name" value="JHP933, nucleotidyltransferase-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="177" mass="20754" checksum="F0BA1716E0A29BDD" modified="2017-06-07" version="1">MAIWRCYSGNRFSVNIDLYSINFPERLTEFQKEIKSNELKLKELKNTGNILCSNISDNDISVKIEINHKYYPENPVEMEYELIDGNTLNVLTLSAESLINEKILAYRDRKFMRDLYDIYVLLKYVDRPETVKSKLLKFINTLEKPVDENVVKTIVYSGLPPSYSKMVDYINQFINST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N414</accession>
    <name>A0A1V0N414_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS116/IS110/IS902 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886504.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N414"/>
    <dbReference type="STRING" id="74969.FAD_0962"/>
    <dbReference type="GeneID" id="16025866"/>
    <dbReference type="KEGG" id="fai:FAD_0962"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transp_IS110-like_N"/>
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    <dbReference type="InterPro" id="IPR047650">
        <property type="entry name" value="Transpos_IS110"/>
    </dbReference>
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        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033542">
        <property type="entry name" value="transpos_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33055:SF13">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33055">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1111A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02371">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase IS116/IS110/IS902 C-terminal" evidence="2">
        <location>
            <begin position="260"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="386" mass="44555" checksum="17983124B9A1A612" modified="2017-06-07" version="1">MERESVNWSGGYMIYVGIDIAKKKFDYCIINSEMNLIKRGILINNNYGFSEFLKIIKNYRNIKIGMESTSIYHVNLYNYLIENSRSAIILNSLETKLLKSSRIRKNKTDKIDAEAIAKYIIIRKNNIITMDKNTENTYTNLKEYVYTYIRINRKITMAKNQLIVDMDLLYPGLTAVANVNSKYFMEIISNIDQIIENNYKIKYISDSKHSEIRNILINSNTNNAVKYDIDINIETLELLNKQLMKTKNIIEDEYNSMDSKIKTIPGIGTITGSIILSSIGDINRFDSIIKLRAYSGMDPVVKQSGDYNITSKISKRGNPLIRYALYLSTVSAIRFNPVIKRYYTRKKNDGMKGNKLLIACSNKLLNIIYSVLKNNKDFEDPLNNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N427</accession>
    <name>A0A1V0N427_9ARCH</name>
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        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
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            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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    <dbReference type="KEGG" id="fai:FAD_0956"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051685">
        <property type="entry name" value="Ycf3/AcsC/BcsC/TPR_MFPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943">
        <property type="entry name" value="CELLULOSE SYNTHASE OPERON PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943:SF4">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN MJ0798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="379" mass="43394" checksum="F8311F8D8D230415" modified="2017-06-07" version="1">MSKVRNNRNIYNHIYFTYSGVKEMKYVEAEISYHKAVQLNDVNAYNNALIEINKAISLDPDNPDYHYTKAISLAGNEQYNEAIEEYDKAISINPKNPDYYVGKGVALDKTGKASEAIKTIDKAISLGPRNSGAYSVKAQILFSNGQHNEAIKEFDKAISFDPKNPKYHEDKALFLRAMYEYDYAIIEYDTLISLYPKNPLYHNSKGNTIVERAASNDRKKYNEAIEEYDTALKLLRYRPEQKRSTPIYAAKAEVVAYVLFDKAVCLEKLGKIEDAINIYTSAKEIDQQRLDPVIRICNLYYNLGKYKEASEVMGELLTYDLDEIPERCERGNCGTADLINCLEIVIKSCQKINNKEDVDLYVNRLLELDPENKLARSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N429</accession>
    <name>A0A1V0N429_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N429"/>
    <dbReference type="STRING" id="74969.FAD_0952"/>
    <dbReference type="KEGG" id="fai:FAD_0952"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="247" mass="29174" checksum="9341BE9B6FBC03BE" modified="2017-06-07" version="1">MSVHLQNKSKHKFDHHLKHKQNFEVLIDAIREASLNVYPYIKIGSKEEPFESFTSRNYSVNWKFWETYSIFSYTSVINKDGKEYEIIRVDKLLYNDIKNHWPEFYENLNKWNEKIKVVGVESTEITNAIIENIYKQLDESNIKAINSPTEYIDKNQKSLQRHALAVYNFVMNTNINEWPNLYSNIGSSEITEPVKKIAENVKREKSAELKKFYGNVKPFLDTAEGLINDLKKLIYDESIKNNCEYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N459</accession>
    <name>A0A1V0N459_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Telurite-resistance/dicarboxylate family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142291.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N459"/>
    <dbReference type="GeneID" id="31676487"/>
    <dbReference type="KEGG" id="fai:FAD_0988"/>
    <dbReference type="OrthoDB" id="57111at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="344" mass="39122" checksum="A2A75A679A1562E2" modified="2017-06-07" version="1">MKNKILYIFGSEWFGMVIATLAVSQVFFLVSKYLVNIDLKYTGEVFFGLGIIMFIVIFILWAIRGLTIHDKKYLHWNNLTRLSFIALIPIILFIMDHILIDLIGMSKLLAEVSLYNYFFSYFLALVLGILLGYRLYTKEIDKNEINYAIIIPPLSIGTSIFLATPLMGYYHGDIAETIYFLVLMGLGIFFFLYIFIGSIALSGHVSNKADSTLPTAMLPVGVSSLIIINLLSIMSFGKVIGDITLNFGTVEFISILLYGFEVWNFIVVFILVFRKTTFGYLSVWAYGFPLGLFATSTIKLESALKIPFLGDIFIFIWIVLMILWVYALINTYVFVDRIKHSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N460</accession>
    <name>A0A1V0N460_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795577.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N460"/>
    <dbReference type="STRING" id="74969.FAD_1010"/>
    <dbReference type="GeneID" id="31676509"/>
    <dbReference type="KEGG" id="fai:FAD_1010"/>
    <dbReference type="OrthoDB" id="57525at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051081">
        <property type="entry name" value="HTH_MetalResp_TranReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033788">
        <property type="entry name" value="HTH_metalloreg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33154">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, ARSR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33154:SF33">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR SDPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="240" mass="27250" checksum="A3BE431739953925" modified="2017-06-07" version="1">MENVSKKGKYDSNHNPGAKSLPDRLFYCLSNPVRLRIILLLSKGKLNVNQLSSTFNVSQPKISAQLSILQNYGIVHGWQVGREKYYKIIPESIESLTSWLDNIATSVTADNLPEFDPHKQFQNGRRCYDHIAGQSGVMLLKLLLSSKWISIKNDKPEYELTDSGEIILTRLGVNIPVQKKHGRIFAYGCMDLTEKEYHLGGALGSEIMKALINQNYIKIYRNTRVIDIIKPIESWFGIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N490</accession>
    <name>A0A1V0N490_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FAD_1043</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16 17">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142407.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N490"/>
    <dbReference type="STRING" id="74969.FAD_1043"/>
    <dbReference type="GeneID" id="31676542"/>
    <dbReference type="KEGG" id="fai:FAD_1043"/>
    <dbReference type="OrthoDB" id="36124at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="18">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="19">
        <location>
            <begin position="106"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ARD84924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="441" mass="50468" checksum="F10F84EA1414C41E" modified="2017-06-07" version="1">MQDEESFIEKLKKDEVEFLQLQFTDISGSVKSLTIPHNRFEDVIYNGVMFDGSSIVGYKQIEDSDMKAVPELSSYTILTNENYAGKTARFVCKIFNSDGTRFEGDPRYILEKQVERLTKENKTYYLGPELEYFLFKQDENGEPTIEPSDYGGYFDKEPLDKAFTVKQEIIRKLEGLHYYPEASHHEVAYSQHEIDVKYSDAITMADRIIMIKSVVKETANEYGYYATFMPKPVKGVNGNGMHVHQSIFSGDENLFYNESNKYGLSDYAMHYLGGILHNVADASLVLASTVNSYKRLVPGYEAPVYIAWANRNRSALVRIPAAPPKGKRMELRFPDAAGNQYLQFAAILGMGLDGIENKTNPPEAMEKNIFEMDLAERQKNGIKSMPGSLGQAIESFRNSELMKKIFGESVFNNLLRIKENEWNEFRSEVTDWEINKYLDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N497</accession>
    <name>A0A1V0N497_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mandelate racemase subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N497"/>
    <dbReference type="STRING" id="74969.FAD_1035"/>
    <dbReference type="GeneID" id="84217632"/>
    <dbReference type="KEGG" id="fai:FAD_1035"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd03316">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="132"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="385" mass="43664" checksum="894AFC9072107819" modified="2017-06-07" version="1">MKIVDLKSYIIKNTWKKWVFIEIITDNGENGYGEATVYNSQFAVVNHIKDIKKFIVNKDPFKVRELVNEWFTSSFNRNRDIVNMSLISGVESACFDLIGKHFGSTIYNLFGGPVRNKIKVYANGWYTNINNIEDWGKEARKVINKGYKALKFDPFGGGSGFLEYDEFKKSMEIIQIVHGVVGDNTEMLIEGHGRFNRSTAMKIGKELEKYPNIEWFEEPVIPEDIDGMAMLSKFLKIPIAAGERLITSYDFTQLFKSNSISIAQPDLINTGGIIELLKIGAMAEANNISIAPHQAEGPLNTFTTLNIDALMNNLKIQEMFDEFAYPAWIGDIVDTVPEVKNGYVELPEKPGIGINLKDKINNYIADENDTDFNLFSEGWEKRGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4A7</accession>
    <name>A0A1V0N4A7_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142397.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4A7"/>
    <dbReference type="STRING" id="74969.FAD_1038"/>
    <dbReference type="GeneID" id="84217635"/>
    <dbReference type="KEGG" id="fai:FAD_1038"/>
    <dbReference type="OrthoDB" id="371889at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052714">
        <property type="entry name" value="MFS_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23531">
        <property type="entry name" value="QUINOLENE RESISTANCE PROTEIN NORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23531:SF1">
        <property type="entry name" value="QUINOLENE RESISTANCE PROTEIN NORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="393" mass="44740" checksum="4F7C896BE7C7FC5D" modified="2017-06-07" version="1">MRVFSNNKNNNIILYITIVIVITFSTRINNNLILTTIPLISKYYLNFNSVEIGILGALAVGSAGIMSALINSKLCSENRRKLFITSIIIYLIFLPLFYFSNRYSIWVFVIISGFFFGTVMPNIISSTGTIKDKKIRERTLALYTLSLSTSLIAGPLLESYLLLYFNLYQLFLFFIPFGILAVALSFKIKFPEENRNERKKKINVFKNKGFQLSIFNNISYDTPFALILTFGGIFAKAEFNAPYSFIEILLAGFFALSFISRLILSYKHLKKLYFTTIISISITIIGLIMIYFSNNLIVYFIIICFLGIPHGLTYPTSLTALSRSFDEDEISIANTYFYAIMMLIAVIVPSISGLMVYTIGLRDTFLFFAFPVIVLFFIIIYDYKKIPGINGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4C8</accession>
    <name>A0A1V0N4C8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142463.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4C8"/>
    <dbReference type="STRING" id="74969.FAD_1076"/>
    <dbReference type="GeneID" id="84217675"/>
    <dbReference type="KEGG" id="fai:FAD_1076"/>
    <dbReference type="OrthoDB" id="43988at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="159"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="498" mass="56475" checksum="43D7136D54CE677B" modified="2017-06-07" version="1">MSILSIVFIIIGIASALYSALILKNGTTFDYIFTAWFWIASVFFGIQSVTYFLSFHRSVTEYTDTIHDSYVPGLRGKVAVLVPIFNEEEEMVITNLVAIYSNAGEDSDIYVLDDSTRGDSAPIIDLCRKLGMKYIHRENRSGYKAGALNNVLKTLEVPYVAVIDIDQTPAPDFLRETTALLAKDPKIGFIQVPQVYSNTDSSILAEIAQAQQFIFYDILTEGKSVAGTLFSCGTNVVYNLDALKSVGYFDENNIVEDIATSVNMAINGWTGVYYNKKLVFGRAPVTMQGYINQQWRWMYGSLSLMPKIVKKILLSKKFSPKQKLDWFATSTWYIFGWFYLIFLLSPILEIVGIRVLTINNLLYLLAWLPYTILLMTTFTLSQVSKKAPLRFVFYNMAANLLIFPLSISTSISVLLKKSKPFTTARTGGNIPLYRFWPQFTILILLPLAAIYLILQHNTFSYITAFWAFFQFTLLMPVFWLNKTPRASSMDDPAFKNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4E8</accession>
    <name>A0A1V0N4E8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4870 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1096</name>
        <name evidence="3" type="ORF">HLB00_00885</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000025">
        <property type="protein sequence ID" value="NOL59394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886200.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4E8"/>
    <dbReference type="GeneID" id="16024325"/>
    <dbReference type="GeneID" id="31676594"/>
    <dbReference type="KEGG" id="fai:FAD_1096"/>
    <dbReference type="OrthoDB" id="329551at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12351" checksum="50EABA0C890B2076" modified="2017-06-07" version="1">MEHKENNIMFIVAYLIPLITGLLVYILYGSRDSKLRFQSIQAILLGICLIVASIIFGIFDIFITGVGGQVISGILDLILVLVWLYGIYTGYRASRGMNANIPYLSDYASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4F4</accession>
    <name>A0A1V0N4F4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoaD/ThiS family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Molybdopterin synthase subunit MoaD / molybdopterin synthase subunit MoaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1144</name>
        <name evidence="3" type="ORF">HLB00_04785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000164">
        <property type="protein sequence ID" value="NOL60151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886248.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4F4"/>
    <dbReference type="STRING" id="74969.FAD_1144"/>
    <dbReference type="GeneID" id="16024373"/>
    <dbReference type="KEGG" id="fai:FAD_1144"/>
    <dbReference type="OrthoDB" id="98357at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="78" mass="8902" checksum="56C892E14C601A48" modified="2017-06-07" version="1">MKIVVLYFAHVRDITGLPQEVFDLETGNMDLLREKIFSKYPQLRAINNLLISVNNEYYSGLPLNENDRVAFFPPVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4J1</accession>
    <name>A0A1V0N4J1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4J1"/>
    <dbReference type="STRING" id="74969.FAD_1133"/>
    <dbReference type="KEGG" id="fai:FAD_1133"/>
    <dbReference type="OrthoDB" id="38238at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="339" mass="37589" checksum="107CE2D426E6BF79" modified="2017-06-07" version="1">MDKIKVSLLGATGMVGQKMIKLLADHPYIELVKLSASDSRIGKKYSETVKWIENGSIPEKFRDMKLVSTSPEDNKDVDYVLSALPPEAAEPVELKLVKNEINVISNASPYRLSKDIPLINPEINFEHLRILEGKDTKFVKNPNCTSAIMAMPLVKLLGFDYDRISLVSMQAISGAGFSGLPYMSIDDNIIPYIHGEEEKIPAEISKMYGTVQDGKINGKNIRMSVTSVRVPVKVGHMGVLNMEIKKGVDVEELIKNLNNFSPLKGFNGLYNAPAHPIVVHNEADRPQNAIDTYNGMEVHVGRISYTDRNLRMVILGNNLVRGAAGITILTLELMEQMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4K0</accession>
    <name>A0A1V0N4K0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1179</name>
        <name evidence="2" type="ORF">HLB00_05425</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000179">
        <property type="protein sequence ID" value="NOL60274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886281.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4K0"/>
    <dbReference type="STRING" id="74969.FAD_1179"/>
    <dbReference type="GeneID" id="16024407"/>
    <dbReference type="KEGG" id="fai:FAD_1179"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="163" mass="18917" checksum="FA7181F9BFA03787" modified="2017-06-07" version="1">MINYDDLEEMLANTDVKYFAFIGDDRNILTGFKENIRNVSTFVAVRKMAKKISVEEYTNTKLKKVEQDDTMVIEQEIKMPDYKFVRLGVFRSMEDVISQAIDEPSMYVFIDSGTTFDSLCKYLSSAEIPFLHIKYNRNGLALNGRRFSSISSLTGYIMKNYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4K3</accession>
    <name>A0A1V0N4K3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable GTP 3',8-cyclase</fullName>
            <ecNumber evidence="10">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">moaA</name>
        <name evidence="12" type="ORF">FAD_1143</name>
        <name evidence="13" type="ORF">HLB00_04790</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000164">
        <property type="protein sequence ID" value="NOL60152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886247.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4K3"/>
    <dbReference type="STRING" id="74969.FAD_1143"/>
    <dbReference type="GeneID" id="16024372"/>
    <dbReference type="GeneID" id="84217740"/>
    <dbReference type="KEGG" id="fai:FAD_1143"/>
    <dbReference type="OrthoDB" id="6925at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_A">
        <property type="entry name" value="MoaA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013485">
        <property type="entry name" value="MoaA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02668">
        <property type="entry name" value="moaA_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001199">
        <property type="entry name" value="PRK00164.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 10" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="13"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL60152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="315" mass="36509" checksum="CCEAFCB6A001F303" modified="2017-06-07" version="1">MLNSVHSGLLYDNFGRPVNSMRIQLNAICNFHCIFCHMEGTERSMQYMTPEQIENVVAVAASHGVNKIKFTGGEPLLREDILEIVRRTRKHITGNISLTTNGVELPKLAKGLKEAGLDRVNISMHAIDEYNFHFITDTKKNFLPIVKQGIQAARDAGLGPIKINFVLMKNINEDQVDGMIKFCAENDSTLQLIEFEANREKEHSEEYLKYHVPLEPIERRIQKQAMDVEHNPLHNRERYTVKTDYGEVKIEFVKPMRNKDFCKHCTRLRLTADGQFKTCLLRENDYFDIKDMLGDESEIDSMYRKAVEARVPYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4M7</accession>
    <name>A0A1V0N4M7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">aIF2-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">eIF-2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">eif2b</name>
        <name evidence="11" type="ORF">FAD_1181</name>
        <name evidence="12" type="ORF">HLB00_06320</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000222">
        <property type="protein sequence ID" value="NOL60446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886283.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4M7"/>
    <dbReference type="STRING" id="74969.FAD_1181"/>
    <dbReference type="GeneID" id="16024409"/>
    <dbReference type="KEGG" id="fai:FAD_1181"/>
    <dbReference type="OrthoDB" id="38099at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="145"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL60446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="203" mass="23120" checksum="E6E72FA7D4D40898" modified="2017-06-07" version="1">MEFDYNKLLKDASGVLSSKNRTEDRLKVPEPEIIYEGKSTIIRNFIDITEMLNRNPEDLVKYFTKEFGIGASVAGRRLIINRKLREEEIREKLNAYMATYVLCYECSSPDTTIEKVGRTYLLVCKACGAEHPIKASREIKENEDQLTEGKTYTVQITEIGKSGEGHAFYGDFTIYVPGTKKGERPKVLIKKIRKNIAIGEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4R9</accession>
    <name>A0A1V0N4R9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4R9"/>
    <dbReference type="GeneID" id="31676721"/>
    <dbReference type="KEGG" id="fai:FAD_1224"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="313" mass="36021" checksum="1E51062C798EE87F" modified="2017-06-07" version="1">MHEIIVDKLVAESLKGNPLRDEYNREIIKIENNVKSSTPVFIGLPGFFGSGNSFLNKSYTSFDFKDLLEKLDTEYGYIMILPDTMTKFGGNQFVDSTAIGNYKSFIARDLVDYIHSLYGNRDIYLFGKSSGGFGSISITLDYPEIFKGFIDISGDSYFPYCYLPDFSTAYLTMKGKTLEGFIESYRQQMVHSQDELETYNVVAMAASYSPDGKNIQLPFSIDTGEILPDVWNKWLEFDPVNRLSGEVEKLKGKKIILQTGNRDEYKINIGMNMIHEILKRNQIDHYYKEYPNGHFNTNYFYLDSFPEILKSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4V5</accession>
    <name>A0A1V0N4V5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4V5"/>
    <dbReference type="STRING" id="74969.FAD_1266"/>
    <dbReference type="GeneID" id="31676764"/>
    <dbReference type="KEGG" id="fai:FAD_1266"/>
    <dbReference type="OrthoDB" id="385043at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="307" mass="34819" checksum="3D74BE1031EDD82D" modified="2017-06-07" version="1">MTYTSIFQEIVKAIIDLSRPSIELLWHMMVKYGLNPEYSYEQFIKGNSPFINFYNYLFYNVYSDVILGIITISALVMLVYNSFIKPYPPAKFLIKTFAAIILFEASYRISMLFISISLVFYNNIYSLKTSWYGLEFSGLSFSNSLISILFTGTFVMAIMLLFGILIIRQALILFFILLMPAASLLLIIPGSEKQILKLYRIFFELAFFPFFTIIILYLIGLFNNPFLEIGLIYVAATAPLFFVTEMYRYFQGTMNFLNADAAVTEISSGIGDINPVSVLNGGINFGIDPDTSESRIPGIIDENGGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N500</accession>
    <name>A0A1V0N500_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1634 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1340</name>
        <name evidence="3" type="ORF">HLB00_03190</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000101">
        <property type="protein sequence ID" value="NOL59838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142820.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N500"/>
    <dbReference type="STRING" id="74969.FAD_1340"/>
    <dbReference type="GeneID" id="84217952"/>
    <dbReference type="KEGG" id="fai:FAD_1340"/>
    <dbReference type="OrthoDB" id="56431at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012861">
        <property type="entry name" value="DUF1634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07843">
        <property type="entry name" value="DUF1634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="133" mass="14722" checksum="7C3437352ACCA205" modified="2017-06-07" version="1">MKNHDDEIIISYFLKAGVMISVSFIVVGVIILFAKNGGDGFTLSQMSNYNYALAHGIDSKSVSLSKIVSGLSAIDGLYFITVGLWVLIFTPITVVFIGWLSFFDDKNYLYVGMASIVLFNLFFAMLVVPRFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N515</accession>
    <name>A0A1V0N515_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal-peptide peptidase, presenilin aspartyl protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_201800965.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N515"/>
    <dbReference type="STRING" id="74969.FAD_1331"/>
    <dbReference type="GeneID" id="16024553"/>
    <dbReference type="KEGG" id="fai:FAD_1331"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010545">
        <property type="entry name" value="SPP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041679">
        <property type="entry name" value="IMP_arch_presen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06550">
        <property type="entry name" value="SPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31635" checksum="69B0EDDA7A79F7E0" modified="2017-06-07" version="1">MKKANQRINSELFGILLFIVSTAFALYLAFNLDQISGIAAESNGISFIFVIYYIVFIVIFTAAALYIIKKHAKIMKAIFIVLVLYMIFLVSSIVAGIVAVNLPEYYAIIAIVTGFFAYMLIFRNEWYITDAAGLIMISGAAAILGILLRPYIAITLLVVFAVYDYISVYKTKHMVTLAKAAIDNQFPLMFTLPSQGGIKIKDLTFDNRGTHSVIMLGFGDMAIPELLIISSAIYNPLHIALFIALTLAGALSALGFLFFFNHGKPAPGLPYINTGVIIGFLIAFAVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N543</accession>
    <name>A0A1V0N543_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerol-3-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N543"/>
    <dbReference type="STRING" id="74969.FAD_1365"/>
    <dbReference type="KEGG" id="fai:FAD_1365"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050385">
        <property type="entry name" value="Archaeal_FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43793">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43793:SF1">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="135" mass="15271" checksum="A400C72D0C4A48CB" modified="2017-06-07" version="1">MASGVFDILHLGHVHYLRESKSFGDYLVVVIASDYTAQKHGKELVFNENERSALVSELKMVDEVMVGHSDDNIFKTVAELKPDIITLGYDQKFDDSYIETECKKLGLNTKVRRTSPYDGTINSSSKIRQKILESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N545</accession>
    <name>A0A1V0N545_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N545"/>
    <dbReference type="KEGG" id="fai:FAD_1402"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="77" mass="8339" checksum="9A0349322F253FA8" modified="2017-06-07" version="1">MLLFLAFGYIGLSIGVFFFVVVIAIFTYLLSHTISVTSYSISLTNGSSIVLAEGTGTLEFLKIIGTKGVEIKFINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N550</accession>
    <name>A0A1V0N550_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142882.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N550"/>
    <dbReference type="STRING" id="74969.FAD_1409"/>
    <dbReference type="GeneID" id="31676901"/>
    <dbReference type="KEGG" id="fai:FAD_1409"/>
    <dbReference type="OrthoDB" id="6342at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047110">
        <property type="entry name" value="GABD/Sad-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43217">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43217:SF1">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="437" mass="48733" checksum="55EF08D1AD3AD4E1" modified="2017-06-07" version="1">MEISTFNPFTEKELGRYDVASIEDVKETMRTLKENQLKWRVDIDKRIDMLKESKKNFEKNAESLATLMSSEMGKPISQSIAEVQKTLRLFDYYIENGEKSLENEYVHTEAKKSYIRFDPLGVIIIIMPWNFPLWQVARAAIPALLAGNAVLLKHASIVSGSSLKIQELFNLDTFRSTITTGKIIDDAIKFSDGVSFTGSTAAGSIIAAEAGKNIKKFVMELGGSDPYIVLDSSNIDEAVKNSVYARLQNNGQSCIASKRFLINDSIYDEFSRRMLEEYSRVKVGDQLDKDTYIGPLSSVSQKDIITKQLKELKSMGTVISTGDNFGNVIRPALVKMDKDYGEEVFGPVAMLSRFRNIEEAIKLANDTPYGLGCSIWGDPDNAEKLVPYIESGTVSINKIVASDPRLPFGGTKKSGIGRELSRYGILEFTNIKTVWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N577</accession>
    <name>A0A1V0N577_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps17e</name>
        <name evidence="5" type="ORF">FAD_1442</name>
        <name evidence="6" type="ORF">HLB00_01320</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000038">
        <property type="protein sequence ID" value="NOL59477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886546.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N577"/>
    <dbReference type="STRING" id="74969.FAD_1442"/>
    <dbReference type="GeneID" id="84220744"/>
    <dbReference type="KEGG" id="fai:FAD_1442"/>
    <dbReference type="OrthoDB" id="52479at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="76" mass="8777" checksum="84F6D91E769C0806" modified="2017-06-07" version="1">MGSIRPSNIKRISEELVDNNKDLFNEDFNHNKEILHSFIEKTVTKKTANAIAGYITRYILKKKSKEKNELEQLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N579</accession>
    <name>A0A1V0N579_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chlorite dismutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1440</name>
        <name evidence="5" type="ORF">HLB00_01310</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000038">
        <property type="protein sequence ID" value="NOL59475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142905.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N579"/>
    <dbReference type="STRING" id="74969.FAD_1440"/>
    <dbReference type="GeneID" id="31676932"/>
    <dbReference type="KEGG" id="fai:FAD_1440"/>
    <dbReference type="OrthoDB" id="8690at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1030">
        <property type="entry name" value="Apc35880, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843:SF1">
        <property type="entry name" value="COPROHEME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="HEME-DEPENDENT PEROXIDASE YWFI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25376" checksum="1D37C0E008FC71E9" modified="2017-06-07" version="1">MTIYMYVLAYKMNGKFWALTDKEKENVNSNIIHFINNYRKNLISIKYYKSIRHDNDILIWSASDTPINLEGLKEGINSAIGIYGKSEYSMFSLYEHSPYVNATNSLEDTLKTEPKKYFVVYPMSKDREWYLINYEERKKILAGHIGTARSDKESPGIISYTTYSFGLGDQEFVVLYELDDLAAWSHVTEKLREVMARKWIINEAPIFVGIYNGDKLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N582</accession>
    <name>A0A1V0N582_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 8">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="2 6 8">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>L-histidine = trans-urocanate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="2 6 8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886507.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N582"/>
    <dbReference type="STRING" id="74969.FAD_1395"/>
    <dbReference type="GeneID" id="16024633"/>
    <dbReference type="GeneID" id="31676887"/>
    <dbReference type="KEGG" id="fai:FAD_1395"/>
    <dbReference type="OrthoDB" id="27422at2157"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000005">
        <property type="entry name" value="Histidine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006871">
        <property type="entry name" value="PRK09367.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4 7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="503" mass="54582" checksum="74DE2819431253E8" modified="2017-06-07" version="1">MIYIDGNNLSIEDVNAVASGSEKVGIAESAIKQIQYSKKSLMKILDSGKPVYGVNTGFGSLLNVNVDRKNIVQLQTNLIRSHSSGIGEPLDIETVRAIMLVRANTLVKGYSGVSENMIDFLLFMLNNNIIPAVPRYGSVGASGDLAPLAHIGLALMGEGDVFYKGKIQNAGTVFKSLGKEPYSYGEKEGVALINGTSVICGILALEIKRSEKLVSEALGSFALAFEGLSGTDKAFTEWALASRPHEGQQMIGKAFRKLFNGSMIIENANKSKVQDAYSLRCTPQVYGAVWDTLQYARKVLTTEINSATDNPLLLGNEYISTGNFHGEPVAMVSDFVAIAMTDFGNMVERRLARIVDTNLSGLPPFLVKDYGLNSGYMIPQYTAAALCNVNKTLVHPNSADTIPTSANQEDHVSMGTNAALKLIEINKNVKSIIAIEYLLGAQSLEFRKHEPSPATLSIYKKIREIVRPLDSDRPSTGDIGAITSMMDTEEFLSLIREKSGFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5C4</accession>
    <name>A0A1V0N5C4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Rhodanese-related sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1441</name>
        <name evidence="3" type="ORF">HLB00_01315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000038">
        <property type="protein sequence ID" value="NOL59476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142906.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5C4"/>
    <dbReference type="STRING" id="74969.FAD_1441"/>
    <dbReference type="GeneID" id="84218033"/>
    <dbReference type="KEGG" id="fai:FAD_1441"/>
    <dbReference type="OrthoDB" id="135517at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052367">
        <property type="entry name" value="Thiosulfate_ST/Rhodanese-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45431">
        <property type="entry name" value="RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 15, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45431:SF3">
        <property type="entry name" value="RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 15, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="118" mass="13911" checksum="33912338D5DFA510" modified="2017-06-07" version="1">MSIKNYFRGSDYFNQPQELENLTPEKLTALKEKYPVIDVRTGFEYRHGHIKGAIPYKLGKEDEIEKKFPKDEPIILICKTGHRSRAAANRLVRKGYKKLYHLEGGMDKWRKENFPVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5D6</accession>
    <name>A0A1V0N5D6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable transaldolase</fullName>
            <ecNumber evidence="5">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fsa</name>
        <name evidence="10" type="ORF">FAD_1475</name>
        <name evidence="11" type="ORF">HLB00_03105</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000098">
        <property type="protein sequence ID" value="NOL59822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886581.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5D6"/>
    <dbReference type="STRING" id="74969.FAD_1475"/>
    <dbReference type="GeneID" id="16024706"/>
    <dbReference type="GeneID" id="31676968"/>
    <dbReference type="KEGG" id="fai:FAD_1475"/>
    <dbReference type="OrthoDB" id="6661at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000018">
        <property type="entry name" value="Probable transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF40">
        <property type="entry name" value="FRUCTOSE-6-PHOSPHATE ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL59822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="223" mass="24262" checksum="8E74CC8DD103A71A" modified="2017-06-07" version="1">MKIFIDTANIEEIKEANEFGLIDGVTTNPSLIMKASKGGKSFKAIATEILREVNGPVSLEVVAEKAEDMVEQALKLHALGSNAVIKIPMTLQGLKAMKILKEKEIKVNTTLIFNAIQALLAAKNGAAFVSPFVGRLDDIGEDGMAIIDQIKTEYTNYGYKTEVLVASIRNPVHVLRAALMGADAVTIPYDVIKKLAMHPKTDEGLNRFLDDWKKVSPDGSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5D8</accession>
    <name>A0A1V0N5D8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5D8"/>
    <dbReference type="STRING" id="74969.FAD_1457"/>
    <dbReference type="KEGG" id="fai:FAD_1457"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF4">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="76"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="305" mass="34205" checksum="BA0982EBA8E9AD6E" modified="2017-06-07" version="1">MNMVDPDFNSLIELSKSAGDMTKIEPAMLRNFLDESSLSSRGAPVEIKEIKDYKIKLDGRTLNARMYDDNNAKSAILYYHGGGFLFGNIETYDNYCRFLAKESGVKIISIEYRLAPEHKFPDAFNDAYDSFHYIAKKKKDFGIEGRIGVAGDSAGANLAAALCLKCRDGKTEMPAVQVLFYPSLAPDNFSRSFIEYSDNYVLTGKMIRYFGNMYSKNMQDLINPYFSPLVADDFSNLPPAIMVTNEYDPLRDPEETYVKKLREAGVRAVGIRGIGMIHGSATDFEVSDGARNIVKMVARIIPDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5D9</accession>
    <name>A0A1V0N5D9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ligB</name>
        <name evidence="14" type="synonym">lig</name>
        <name evidence="17" type="ORF">FAD_1498</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 14 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795592.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5D9"/>
    <dbReference type="STRING" id="74969.FAD_1498"/>
    <dbReference type="GeneID" id="31676989"/>
    <dbReference type="KEGG" id="fai:FAD_1498"/>
    <dbReference type="OrthoDB" id="31274at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07901">
        <property type="entry name" value="Adenylation_DNA_ligase_Arch_LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="16">
        <location>
            <begin position="329"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="14">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ARD85352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="582" mass="66245" checksum="E8595E0516B1477E" modified="2017-06-07" version="1">MLFSEASKKFMEMESTTKRLELTSILGSLLENAGDDLKELVYLIQGKLAPDYEGIEFGVSGKLIVKSLAAISGMDEEEVNKLFYKNGDLGITASEIREKMEQKPLFREDLTVHYVYTRLMELAKSAGHGSVKGKTDIYADLMVNSYPEDIKYITRIIMGKLRLGVADSTILDSLVHAFFSKDNADMVETAYNFHPDIGLIATLLQKGDIKAISNIGPEPLIPFKVMLAERLRSIDDIREKMNHHVSFEYKYDGLRTELHKKGDKIKIFSRGLEETTENFPDIIENFKKSYSFESIIIDGESVPFNPDTGELFPFQMVSKRRGRKYQITEKSTEIPLVMFIFDILELNGRILVNLPYEERRKILEENFVDNEHFRLATRLSSDDSEEINKFFEQSIEDGCEGIVAKDTSDESVYRAGARGWLWIKFKRDYQKELADSMDLVIIGAFNGRGRRAGAYGALLMASYNEETHAFESVTKLGTGFSDEVLFSLPKMLSDLVRDHKPAMVESKMVPDIWIYPQIVMEIQGAEITVSPIHTCAFGKIEKDSGLALRFPRLIKIRDDKNAEDATTTNEIIELYKMQKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5F3</accession>
    <name>A0A1V0N5F3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">albA</name>
        <name evidence="7" type="ORF">FAD_1516</name>
        <name evidence="8" type="ORF">HLB00_09460</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds double-stranded DNA tightly but without sequence specificity. Involved in DNA compaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Acetylation at Lys-11 decreases DNA-binding affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000417">
        <property type="protein sequence ID" value="NOL61045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886655.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5F3"/>
    <dbReference type="SMR" id="A0A1V0N5F3"/>
    <dbReference type="STRING" id="74969.FAD_1516"/>
    <dbReference type="GeneID" id="16024782"/>
    <dbReference type="GeneID" id="84218109"/>
    <dbReference type="KEGG" id="fai:FAD_1516"/>
    <dbReference type="OrthoDB" id="10360at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00285">
        <property type="entry name" value="DNA-binding protein Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003088">
        <property type="entry name" value="PRK04015.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4 5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="6">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL61045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="90" mass="9982" checksum="841C48A3DA19FCE1" modified="2017-06-07" version="1">MSEENIIFVGKKPTMNYVLAIVTQFNNSDMPRIVIKARGKAISKAVDIAEITKHKFIQTAKYESIKLDTETLEGENGPSNVSSIEIILAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5I7</accession>
    <name>A0A1V0N5I7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VapB-type antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1493</name>
        <name evidence="2" type="ORF">HLB00_07820</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000290">
        <property type="protein sequence ID" value="NOL60733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142928.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5I7"/>
    <dbReference type="GeneID" id="84218087"/>
    <dbReference type="KEGG" id="fai:FAD_1493"/>
    <dbReference type="OrthoDB" id="381080at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="82" mass="9402" checksum="A0EEE869D4871FAB" modified="2017-06-07" version="1">MNKVVSIRLSDDMLNTTNKLISFKIVNSRTDAINYIMEHGINNVNNVIKKKEKTQELLEKYLKEGLPELPAGLSEKSILERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5J2</accession>
    <name>A0A1V0N5J2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1524</name>
        <name evidence="8" type="ORF">HLB00_07270</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000267">
        <property type="protein sequence ID" value="NOL60628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886661.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5J2"/>
    <dbReference type="STRING" id="74969.FAD_1524"/>
    <dbReference type="GeneID" id="16024790"/>
    <dbReference type="KEGG" id="fai:FAD_1524"/>
    <dbReference type="OrthoDB" id="27340at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="321" mass="34918" checksum="38B032DD76B5AD4A" modified="2017-06-07" version="1">MMQFNISSTERDYETDYDVIIIGAGAAGYSAGVYIKRSGMSVAILERESVPGGNTAVSPLVENYLGYKAIEGADLAEDFRKHYAQYGKIITEIDVRDIKKEGDKFRIITNRSDFTAKAIIVTTGTTHRKMNVKGEDEYYGKGISYCSTCDGYLFKDKNVAVIGGGNSGAISALYLKGIAKNVSIIAHSKIKKCEDAYIKSIDEKKIPFILNAETEEFIGDGKKLTGLKYKDLATGEEKTENLDGIFVYIGVIPQTSFLKNIGVKLDKHGFIIADEKGRTNIPGIYGAGDVLAGSEEQIATAVGDGSKAAITLYTDIINKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5K4</accession>
    <name>A0A1V0N5K4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative arsenical pump-driving ATPase</fullName>
            <ecNumber evidence="8">7.3.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arsenical resistance ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Arsenite-translocating ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Arsenite-transporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">arsA</name>
        <name evidence="15" type="ORF">FAD_1514</name>
        <name evidence="16" type="ORF">HLB00_07715</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Berkeley</strain>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Anion-transporting ATPase. Catalyzes the extrusion of arsenite.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenite(in) + ATP + H2O = arsenite(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29242"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.7" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000289">
        <property type="protein sequence ID" value="NOL60715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886653.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5K4"/>
    <dbReference type="STRING" id="74969.FAD_1514"/>
    <dbReference type="GeneID" id="16024780"/>
    <dbReference type="KEGG" id="fai:FAD_1514"/>
    <dbReference type="OrthoDB" id="46198at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015446">
        <property type="term" value="F:ATPase-coupled arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001801">
        <property type="entry name" value="Putative arsenical pump-driving ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="13">
        <location>
            <begin position="3"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA HSP20-like" evidence="14">
        <location>
            <begin position="323"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="NOL60715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="386" mass="43449" checksum="076871FEFA0BAC28" modified="2017-06-07" version="1">MARVLLYTGKGGVGKTTVAASTASMLAKQNKKTIVMSTDPAHSLGDSLQAEIKSSPTEISKNLFAQEVNINDAIQSHWSDLREYLTALFQYQGLDPISADEIAILPGFEEATYLLYINDYIKNNSYDVIVVDSAPTGEALRMLSFPEVMRWYMEKVFPISRTAAKIARPLMRPFSGIPMPNDKVFKSAETLYDDLGDIHTILENPDITSIRLVTNADQMSFNETKRAFTYLLLYGYPVDAVIANKIYTEDTGDFFQKWRETQSGILGDLDAAFPEIKILKSYLQNNELVGQEKALKFGQDLYGDLDPYSVFYKGKPLEFIRKNGNSVVKLKLPFADKKNLNLYNKTGELIVEVNNWKRILYLPQTMANLQPSGAELKDGYLYITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5L3</accession>
    <name>A0A1V0N5L3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1536</name>
        <name evidence="2" type="ORF">HLB00_03595</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000114">
        <property type="protein sequence ID" value="NOL59917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142946.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5L3"/>
    <dbReference type="STRING" id="74969.FAD_1536"/>
    <dbReference type="GeneID" id="84218129"/>
    <dbReference type="KEGG" id="fai:FAD_1536"/>
    <dbReference type="OrthoDB" id="12193at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="105" mass="11836" checksum="74B57CB878F1585B" modified="2017-06-07" version="1">MYDAWNTLCALAFTADKIEVPKSIGNPMETGLFVRSVGSPRGQIRDYRGNVDGSNLGIHVVEFLGHYEVHVDRFDPYKKPVEHLIVDSPGTLLEIPLLLRMLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5L8</accession>
    <name>A0A1V0N5L8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">Chorismate synthase</fullName>
            <shortName evidence="7">CS</shortName>
            <ecNumber evidence="3 7 8">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroC</name>
        <name evidence="10" type="ORF">FAD_1530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="7 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142944.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5L8"/>
    <dbReference type="STRING" id="74969.FAD_1530"/>
    <dbReference type="GeneID" id="84218123"/>
    <dbReference type="KEGG" id="fai:FAD_1530"/>
    <dbReference type="OrthoDB" id="33049at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="298"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="356" mass="39336" checksum="7EC114E62D3C888A" modified="2017-06-07" version="1">MFSLGNEIKLTVFGSSHGPYIGGTVDGLPAGLAIDQEFIQKWLDRRKPGQSLITTPRNEDDKIEIIGGSRKGFTDGSPLAFIFKNKDYIDKHYDDLRDNPRPGHADLTMFYKYGEYRNYEGGGFFSGRMTMPLVAAGAFAMGVLKRYNIKIVTYIKSAGGISIDNEPQEDEDYVYGFSTRMPDREKDSLLYNKILESIKNGDSMGSVISTHIYNVPPGIGEPFFNSVESEISRAMFSIPGLKAIEFGSGFKLGNMYGSEANDEFYAENGKILSRTNNSGGVLGGITNGMPVVFNIAMKPTSSIRIPQKTVNLKSMEPSEVQVKGRHDPFISFRAVPVIQAMAAFVMLDLIMCRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5M3</accession>
    <name>A0A1V0N5M3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">3-dehydroquinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_1605</name>
        <name evidence="12" type="ORF">HLB00_01610</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000043">
        <property type="protein sequence ID" value="NOL59533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142981.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5M3"/>
    <dbReference type="STRING" id="74969.FAD_1605"/>
    <dbReference type="GeneID" id="84218200"/>
    <dbReference type="KEGG" id="fai:FAD_1605"/>
    <dbReference type="OrthoDB" id="21407at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF7">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="9">
        <location>
            <begin position="61"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="10">
        <location>
            <begin position="173"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL59533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="357" mass="40031" checksum="F503B4FF941D137B" modified="2017-06-07" version="1">MEILEKPINGKNIKMYIGSGLENKINSFMEDYGKNISFVSYALKQLYKSKINAISSYKSFLKDGESSKSQKYVNIVIKKLINMEIERDNSVSYIGGGTIGDLIGYSASVYKRGVHLIGIPTTLLAQVDSSIGGKNAINFENLKNAMGTFYNPDVIFADVDFLLGSDPALLRDGIAEAMKMALVKDREFFNYFTSKNLNSIYNRKSLEYVISKSAKIKLDVVSEDFFDSRKIRYLLNFGHSIGHAIESYTENRVSHGTAVANGMILESYLAYKAGFSEPFYETVRDAVSAYGIPLLDFNTIETDKLVSFIKNDKKVENGKLNMVMLKGPGQAEIGEIGFQQMRMYVNLYKERSTKGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5M4</accession>
    <name>A0A1V0N5M4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12 13">Pyruvate kinase</fullName>
            <ecNumber evidence="3 12 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pyk</name>
        <name evidence="16" type="ORF">FAD_1603</name>
        <name evidence="17" type="ORF">HLB00_01600</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Berkeley</strain>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 12 13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000043">
        <property type="protein sequence ID" value="NOL59531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886736.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5M4"/>
    <dbReference type="STRING" id="74969.FAD_1603"/>
    <dbReference type="GeneID" id="16024869"/>
    <dbReference type="GeneID" id="84218198"/>
    <dbReference type="KEGG" id="fai:FAD_1603"/>
    <dbReference type="OrthoDB" id="56298at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="2"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="15">
        <location>
            <begin position="351"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="NCBIfam" id="TIGR01064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD85448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="NOL59531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="559" mass="61429" checksum="0C971BBE78A0CCA2" modified="2017-06-07" version="1">MTKTKIVATLGPASFDESIITKMADKGLATIRINTAHISEGYITDVSRLVYKINEKYNKKLGIMVDLKGPELRTGEFPGGILNITAGNTYGISDNPGVKSDISINYKISDYVDKDTLIAINDGRVRFNVESISNGVITTRAMDTGTIHDRSRVNIPGKYIDLGVLTDRDKMFLEEGLKNNINFYALSFVQSRENVYELQDYIYDRKGQGDIISKIETKSGYDNLESIVKASDFIMVARGDLGVELPLKEVAMAQKRIIDISHKYAVPTIVATQMLESMVNSDSPTRAEVSDVTNAILDDTDAVMLSEETAIGKYPVEAVTYLYEISKYVESQSTSFPEPENFMVDPIAFSVAKGVKIMSNTIDVSSIIAMTRTGHTAKILSAIRPVNDIYAIVQTEWLARSINLMRGVIPVVLPEAQAKEENIYDIINKIAPLGLLNPGEKAIVVSGSPSLYLGGTNNIRVISIGRFIGRGYPAGHNVTGKIDTDAPENGNIILLDRYDSNIDYSKYNAAIIKSDVTNRIIDKFLDAGKTLVYNAELVKQINKNTTISIDADTGIITEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5P6</accession>
    <name>A0A1V0N5P6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acylphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1557</name>
        <name evidence="5" type="ORF">HLB00_00965</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142952.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5P6"/>
    <dbReference type="STRING" id="74969.FAD_1557"/>
    <dbReference type="GeneID" id="84218151"/>
    <dbReference type="KEGG" id="fai:FAD_1557"/>
    <dbReference type="OrthoDB" id="6643at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268:SF4">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="89" mass="9816" checksum="63619301881E4823" modified="2017-06-07" version="1">MSTVKFVFHGTVQGIGFRAHVKKKAMELGIKGWVKNNQDGSVSAVFSGDEEMISIMDGYCRKIPLAELSSVESMPADDANFDSFEIIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Q1</accession>
    <name>A0A1V0N5Q1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-glyceraldehyde dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="8">1.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_1602</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NADP-dependent dehydrogenase of the nED (non-phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D-glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3-phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-glyceraldehyde + NADP(+) + H2O = (R)-glycerate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:40163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16659"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.89"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; glycolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer. Dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aldehyde dehydrogenase family. Glyceraldehyde dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.89" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886735.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Q1"/>
    <dbReference type="STRING" id="74969.FAD_1602"/>
    <dbReference type="GeneID" id="16024868"/>
    <dbReference type="KEGG" id="fai:FAD_1602"/>
    <dbReference type="OrthoDB" id="6342at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043796">
        <property type="term" value="F:glyceraldehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009255">
        <property type="term" value="P:Entner-Doudoroff pathway through 6-phosphogluconate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000022">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053507">
        <property type="entry name" value="NADP-Glyceraldehyde_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040792">
        <property type="entry name" value="glyc_ald_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00055147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD85447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="493" mass="54439" checksum="3A69D080B01F4035" modified="2017-06-07" version="1">MKIYIDGTWKESSNGNTLNKYNPSTGEVLDTFPAATKDDIDAAMDSAESAFPSWSDMGTQERAKILYKAVELISQKRGELENLLTLEVGKIKREAIDEVDGVIDQIQYYAEFERKLTGDIVEGSSSKRKIFQYKVPYGIVVAITPWNFPAAMVVRKLAPALLTGNTVILKPSSDTPLTANWIVNKFIEAGIPKGVLNFVTGRGSEIGDYIVNHKKVGLVTMTGSTSTGQKIMQNASSNMAKLILELGGKAPFIVWKDADMIRALKSLIWAKYLNVGQSCIAAERLYIHEDIYDKFMSKFVAITKKLTTGDPDTSDVGPLINKNALAGMVQTVNNAKDSGYKILTGGNTPDLQGKYKNGYFFAPTIIENVPQDSGLFQDEIFGPIIGTEKISGVDEMYRKANDSKFGLASYLFTEDPELMLEASEKIRFGELYINMPGPEASQGYHTGFRMTGQAGEGSKYGINEYLKLKNVYVDYSKKALYINTINNSLFDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5T9</accession>
    <name>A0A1V0N5T9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="2 9">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">argS</name>
        <name evidence="12" type="ORF">FAD_1604</name>
        <name evidence="13" type="ORF">HLB00_01605</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2 9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000043">
        <property type="protein sequence ID" value="NOL59532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886737.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5T9"/>
    <dbReference type="STRING" id="74969.FAD_1604"/>
    <dbReference type="GeneID" id="16024870"/>
    <dbReference type="GeneID" id="31677094"/>
    <dbReference type="KEGG" id="fai:FAD_1604"/>
    <dbReference type="OrthoDB" id="372102at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="433"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="NCBIfam" id="TIGR00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL59532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="542" mass="62789" checksum="A31752FD24D35A06" modified="2017-06-07" version="1">MLLFDDYKKIMLDKIKTIYSVQDNDMELGTNFGDFTLKIFKFKDNREEVYSRIKSSMDMEFIDRVELQGNYINFYIKSSKMLDTVENSIGTFGKYPNTFQDTSKALIEHTSSNPTGPIHVGRIRNSIIGDSIFRIIERYGTRSLTQYFVNDSGKQVISLYLGHIKYHKDEEMTVENLLDGYQKIYTNIDSDPDIKREVQELDEKYETGDNELIKEIQNTASIVLKSITDSLAKLGIHISTYVWESNFIMYGNVAQLIDSLSEDLKSEGKAKYIEIGDKKIFLTRQDGTSLYFARDLVYHMFKSENFDWIIDVLGEDHKDHAKNLDYVLHNYLDFPSRIDYLFYGFVSLDTGKMSTRKGNIVTVNDLYEKTVEESAAIIKQKRPEYSKEEVDKISNAIAASSIRYNIIKINANKPLTFRWDEALNFEGDSAPYIMYAYARACSLISKTGNTESSTEEYNEFEKALIKAMYVYPYYLQNSVDFLRADIIAGYILYLVKSFNEFYLNCPIIGNSEENKRMRIVRAFKKIMEDSADLLGIQLLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5V2</accession>
    <name>A0A1V0N5V2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143027.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5V2"/>
    <dbReference type="STRING" id="74969.FAD_1686"/>
    <dbReference type="GeneID" id="31677178"/>
    <dbReference type="KEGG" id="fai:FAD_1686"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="8350" checksum="3E8A8A73F79CEDCB" modified="2017-06-07" version="1">MPKTITIKKSVYDELIGVKKKNESFSELLERLVKSQSKQELLLSLRGRIEFEGKDELLKEVEKKRWEREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Y4</accession>
    <name>A0A1V0N5Y4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Y4"/>
    <dbReference type="STRING" id="74969.FAD_1661"/>
    <dbReference type="KEGG" id="fai:FAD_1661"/>
    <dbReference type="OrthoDB" id="7950at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012206">
        <property type="entry name" value="Fd_FixX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43082">
        <property type="entry name" value="FERREDOXIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43082:SF3">
        <property type="entry name" value="FERREDOXIN-LIKE PROTEIN YDIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="88" mass="9824" checksum="1B93D1D26E66074F" modified="2017-06-07" version="1">MDLIKRLGLNKNEVGNQSHIEVNTDMCKICVDKPCIKVCPAGTYEEDKENGISVHYERCLECGAALYACPFGALQFKYPEKGVSYIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N609</accession>
    <name>A0A1V0N609_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940568.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N609"/>
    <dbReference type="STRING" id="74969.FAD_1676"/>
    <dbReference type="GeneID" id="31677168"/>
    <dbReference type="KEGG" id="fai:FAD_1676"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="338" mass="37908" checksum="3E159D8F138F1E16" modified="2017-06-07" version="1">MNMKMLAAIFIALTIIFAGLFIGFYAVDNSTIAHKDTQLKKSQNAYSDAKASSALEAAYAHWNNITIENLANVSAGYTDNATLHWIGGPLNGVYSGIANINSTWSKFFKTWSAVWFYAETPPTVVVNGNYSNVTSTNQFILTPFNNETQVQYLNVSYTLDMMYMDNSWHIYNEIWHITGSGYVSYAQEFAEYNEINALSLQHWNQIAIENLSLIMKEYANNATLHWIGGPLNGTYSGITSINSTWNKFFTAWKAVWFYASTSTTNNPEISINGNMATVSANFTQFIVQNATTNAFQYINTTYAITYYNYGFNGHLGENSFKIVNETFHITGSGNLTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N622</accession>
    <name>A0A1V0N622_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CTP synthase</fullName>
            <ecNumber evidence="11">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="11">CTP synthetase</shortName>
            <shortName evidence="11">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrG</name>
        <name evidence="14" type="ORF">FAD_1721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>UTP + NH4(+) + ATP = CTP + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N622"/>
    <dbReference type="STRING" id="74969.FAD_1721"/>
    <dbReference type="KEGG" id="fai:FAD_1721"/>
    <dbReference type="OrthoDB" id="52769at2157"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
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        <property type="term" value="F:metal ion binding"/>
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    </dbReference>
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            <begin position="3"/>
            <end position="257"/>
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            <begin position="1"/>
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        </source>
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</entry>
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    <accession>A0A1V0N639</accession>
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        <name type="scientific">Ferroplasma acidiphilum</name>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="NOL59238.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="240" mass="27149" checksum="FED06D37942441D0" modified="2017-06-07" version="1">MIGLINLSHSDPLSMTFSPDEIVRKSAADNYRDLEEGRTEIGMVSLVTYLEHSDKLNLVKSINIHTKANSISTILLSRSGYLKNNIKINVTSLTKTTEFYLKLVLEKMGISFELKESGYSDYENLLKDADYALVIGDEAIKAYSGSANILLDVGLEFSKLYGLEPVYAVAASRNAVDNARISDLDKHIEDSKKYIKESAEKNSLKFHVKRELMEEYYRVMDYSFNNSVMKTIEFARKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N656</accession>
    <name>A0A1V0N656_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH bat-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85569.1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236:SF1">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH bat-type" evidence="1">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="210" mass="23923" checksum="9D5EFBA14CAF3B8F" modified="2017-06-07" version="1">MKNEGCSLSGLYSEYNINSRVIKKEIHEGLLYEIAEIYYHNGNLDKILISLKSSQGVKGVETLFDNGNILIIKLTTAECPVLGILKNYSESGKSVYKQEEKIEEGNNIWNMHIASMELVRELSEKLKEKTGSDVFVNIYKKSSVDKKSLFVVKEAYDLGFFDVPKRINLLELSAILNIPPTTLDLIIRKSLKYFLDTELVSKDKSQIYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N674</accession>
    <name>A0A1V0N674_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="16">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="16">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">coaD</name>
        <name evidence="19" type="ORF">FAD_1778</name>
        <name evidence="20" type="ORF">HLB00_08055</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Berkeley</strain>
            <strain evidence="21">Y</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ITP + H2O = IDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28330"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58280"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XTP + H2O = XDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28406"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59884"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="16">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the eukaryotic CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="16"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000298">
        <property type="protein sequence ID" value="NOL60779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143084.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N674"/>
    <dbReference type="STRING" id="74969.FAD_1778"/>
    <dbReference type="GeneID" id="31677268"/>
    <dbReference type="KEGG" id="fai:FAD_1778"/>
    <dbReference type="OrthoDB" id="53228at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103023">
        <property type="term" value="F:ITPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00647">
        <property type="entry name" value="PPAT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023540">
        <property type="entry name" value="PPAT_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050299">
        <property type="entry name" value="YjjX_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001985">
        <property type="entry name" value="PRK00777.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34699:SF2">
        <property type="entry name" value="NON-CANONICAL PURINE NTP PHOSPHATASE_PRRC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 16" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 16 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="17">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Non-canonical purine NTP phosphatase/PRRC1" evidence="18">
        <location>
            <begin position="155"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ARD85617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="NOL60779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="324" mass="36729" checksum="606698B3FF8EC970" modified="2017-06-07" version="1">MITLVGGTFNRFHKGHEQLLLAAYNTGNKVMIGVTSDEYARKHKNIVISYKRRKARVERFMQKFTDNYEIHPLDSMFGNTLDVKDAILVVSPETHAGAIRINERRLSMGKNPLHIVKIPFTLGEDLFPISSTRIIKGEITVTGKRKTPVNIAISTGNELKLEATEKFIKTIMKNYRITRNTEYSTGSEQPFGSDTIRFATDRAMYGLKDNDYSIGIESGIFYNPVNNMYYDLHYCVVIDRYSVITTGFGSGFQMPDQVIDAIKNGTSTNEFVEAKYGIKKIGHGRGISGLISEDSVTRATLVYESVRNAFIPRMRPDIYCRRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N681</accession>
    <name>A0A1V0N681_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate dehydrogenase E1 component alpha subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1756</name>
        <name evidence="4" type="ORF">HLB00_08560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000319">
        <property type="protein sequence ID" value="NOL60874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886898.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N681"/>
    <dbReference type="STRING" id="74969.FAD_1756"/>
    <dbReference type="GeneID" id="16025031"/>
    <dbReference type="GeneID" id="31677247"/>
    <dbReference type="KEGG" id="fai:FAD_1756"/>
    <dbReference type="OrthoDB" id="25266at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="2">
        <location>
            <begin position="17"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="344" mass="38988" checksum="184915CF79FC3865" modified="2017-06-07" version="1">MIEETDISKEGLLAAYKNIVMERLFDKKMLNASRQGFLPFYIPLMGHEAIHIGMGMAIRDEDFFYPYYRDFGVLIQMGIPIDTILSQVFATATDNEIGRDMPDHFSLKKYNIGAVITPVAGHLTSATGIAYAKKYRKESGSVITTFGDGATSTPDFHVAMNFAGVYKLPMVFFCENNQFAISVPTYPTDDKAFNQTYEETRGAIYKKAESYGFSGIRIDGTNFIEVYRATRKALENASEDPILIEAMTYRMGPHSTADDPNKYRTDRVPEGSEKDPLIVSQKLLKDMKVITDLDIKQINDEMEETTSKLIDTYEKAPKPDKETMMGNLYEEEPWYISEERGDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N684</accession>
    <name>A0A1V0N684_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA splicing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143082.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N684"/>
    <dbReference type="STRING" id="74969.FAD_1775"/>
    <dbReference type="GeneID" id="31677265"/>
    <dbReference type="KEGG" id="fai:FAD_1775"/>
    <dbReference type="OrthoDB" id="46045at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="tRNA-intron endonuclease N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="1">
        <location>
            <begin position="205"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="288" mass="33533" checksum="5A405F283B02E769" modified="2017-06-07" version="1">MEIVCRNTHFVLSGMDISQIINKYHVGKMRDNVLELNPCECIYLYMKGKIMPEPEMGLPQVISSVFTEDLYIYYVYSILKEKGLIVKRDGNKFFYKKTGGEYGIPVILIKEGDLIDFSSLYVDLPAIFITVDEEKSITYFRADFIDPEGNADSDISIGNPEKLNNIYYTTNSHPEWFGQEFMGVKILNQFEANYISGELKTDEDKLYRDLIKRHFIVKSGFKYGQNFRIYSDSMENHAEFLVSLMTSEKWYKISRAIRLSTSVRKKTLIAGFIGNDLKYIYIERLRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6A3</accession>
    <name>A0A1V0N6A3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886924.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6A3"/>
    <dbReference type="STRING" id="74969.FAD_1776"/>
    <dbReference type="GeneID" id="16025055"/>
    <dbReference type="KEGG" id="fai:FAD_1776"/>
    <dbReference type="OrthoDB" id="56314at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="165" mass="18892" checksum="020000EAD9017FE5" modified="2017-06-07" version="1">MVQKLIWKVTVTGKKNSGKSSIVSRAVYNTATQISSRGFIRKKVNTNFMSEDYDIDLLFLEMPYETLNDKFLSKSTFVLFVVDITDMESLQDAGKFLSEFPDMEVFIIATKSDMRYASEFWEPEISKLADKYGSIYFIYSSHDDFSGILNDVIGYALAKIYNPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6C4</accession>
    <name>A0A1V0N6C4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FAD_1847</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16 17">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143120.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6C4"/>
    <dbReference type="STRING" id="74969.FAD_1847"/>
    <dbReference type="GeneID" id="31677337"/>
    <dbReference type="KEGG" id="fai:FAD_1847"/>
    <dbReference type="OrthoDB" id="36124at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="18">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="19">
        <location>
            <begin position="106"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
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        <location>
            <position position="242"/>
        </location>
        <ligand>
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            <label>1</label>
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        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
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            <position position="313"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ARD85683.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
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    <sequence length="441" mass="50453" checksum="4879AF88DDA18FA5" modified="2017-06-07" version="1">MQDEESFIEKLKKDEVEFLQLQFTDISGSVKSLTIPHNRFEDVIYNGVMFDGSSIVGYKQIEDSDMKAVPELSSYTILTNENYAGKTVRFVCKIFNSDGTRFEGDPRYILEKQVEKLTKENKTYYLGPELEYFLFKQDENGEPTIEPSDYGGYFDKEPLDRAFTVKQEIIRKLEGLHYYPEASHHEVAYSQHEIDVKYSDAVTMADRIIMIKSVVKETANEYGYYATFMPKPVKGVNGNGMHVHQSIFSGDENLFYNESNKYGLSDYAMHYLGGILNNVADASLVLASTVNSYKRLVPGYEAPVYIAWANRNRSALVRIPAAPPKGKRMELRFPDAAGNQYLQFAAILGMGLDGIENKINPPEAIEKNIFEMDLAERQKNGIKSMPGSLGQAIESFRNSELMKKIFGESVFNNLLRIKENEWNEFRSEVTDWEINKYLDIY</sequence>
</entry>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="79" mass="9302" checksum="415ECF5231B20945" modified="2017-06-07" version="1">MIEMDYRNVSCGGDPFNFLMSSIKSIQIEIEPSDTVKVMLIKDKFPYDNKTFEKIVNYCKLSIVDICRENNEIYLLLRK</sequence>
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        <citation type="journal article" date="2011" name="Proteomics" volume="11" first="52" last="63">
            <title>Iron homeostasis and responses to iron limitation in extreme acidophiles from the Ferroplasma genus.</title>
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                <person name="Jonna V.R."/>
                <person name="Dopson M."/>
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                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="22"/>
            <end position="201"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADR78327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A1V0N1D0</accession>
    <name>A0A1V0N1D0_9ARCH</name>
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        <submittedName>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
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            <taxon>Methanobacteriati</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
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    <dbReference type="STRING" id="74969.FAD_0013"/>
    <dbReference type="GeneID" id="16025159"/>
    <dbReference type="KEGG" id="fai:FAD_0013"/>
    <dbReference type="OrthoDB" id="6635at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF17">
        <property type="entry name" value="PROTEIN FIXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="1">
        <location>
            <begin position="262"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="557" mass="61388" checksum="96BBD833997ECC6F" modified="2017-06-07" version="1">MKIIVLVKQVPDVNAIRFDEKTKRIIRAGVKLSFNSYDKKAVEAAVRLSEKYKCETYVVSMGPGDARDVLNDSMKMGINHAILLNDPNFAGSDTYVTSRILSSLIMHISPDIVLSGKSSLDGETSQVPPETAEMAGYNFVSNVSSIEIAENRVIVARDEDNGIRKLEVSFPVFLSVSEKINRARQIDPSAKVENIDIYDSRFTAWKGSDSPTSVVDTFSMANTRNNKFITFQEFLGILNSSGEVKQDPDYKILDDPATEEIFLGLAVDDPGTSLEISSKIAEIGGHRIVVIGNINPSRLNGMACHKYIYLDNSDYVSFSEYVAEFIRKNKVRHVLAPSNLNGRDISSHIAASIGLGLTADCVDIKFESGKMVQYKPSFGGGIIAVIKSKTEPDMATVRKGMFPIKFRSKSYDVQTVNLEKNENFHEIDNTPIDSNLHPLDTPVIFGIGTGVHAEDIPHILEIAEKINASVGATRRVVDMGRIPRQFQIGLTGMSISPSLYVALGISGSDNHIVGIRYAGKVMAVNNNPDADIFKHSDFGMIMDTHEFIENLYTFVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1E5</accession>
    <name>A0A1V0N1E5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795601.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1E5"/>
    <dbReference type="STRING" id="74969.FAD_0003"/>
    <dbReference type="GeneID" id="84218494"/>
    <dbReference type="KEGG" id="fai:FAD_0003"/>
    <dbReference type="OrthoDB" id="377072at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD83939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="78" mass="9355" checksum="7A15588B4712C352" modified="2017-06-07" version="1">MGRNTQSSREYVKSMEEEILSMRTYMKKEDIEILKVIISMAEKHSNEISNFNQFFAAIILELYKKLDGYGEDNKRHWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Q4</accession>
    <name>A0A1V0N1Q4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpD</name>
        <name evidence="6" type="ORF">FAD_0104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141338.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Q4"/>
    <dbReference type="STRING" id="74969.FAD_0104"/>
    <dbReference type="GeneID" id="31675616"/>
    <dbReference type="KEGG" id="fai:FAD_0104"/>
    <dbReference type="OrthoDB" id="8214at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="5">
        <location>
            <begin position="68"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="102"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="324" mass="35733" checksum="CDD3BDA8FED6F1BD" modified="2017-06-07" version="1">MNNDINYAATGNEIIKARDTMMELVDSPDSAKISFLTDIHNRGETPAEIAGFAMALRELSSLNLNYPELTDVVGTGGDGKNTVNVSTGVSILLASMGIKTAKHGNFGVTGHHGSADFMKYMNYNFKMDKNTIIENISRKNYVYILAPEYNKSFAKFSAARKQISFRTVFNILGPLTNPLNPARVVLGTYSEDLAELYAKVIKEEKKKGFIVHGSDGMDEISPSSKSTLYRVDGHLDKITIDPEKLIGHSINPEDVSTTDSIKSFEMLLDGLSGRNKNVMEFIAINALPAVLLNQKADSFEEAYDLSVDFIQRGKAIEKLKEVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1R5</accession>
    <name>A0A1V0N1R5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">anthranilate synthase</fullName>
            <ecNumber evidence="1">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="1"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141333.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1R5"/>
    <dbReference type="STRING" id="74969.FAD_0101"/>
    <dbReference type="GeneID" id="31675613"/>
    <dbReference type="KEGG" id="fai:FAD_0101"/>
    <dbReference type="OrthoDB" id="3321at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="186" mass="21156" checksum="84B2CC2D0AF3BC72" modified="2017-06-07" version="1">MKKILIIDNYDSFVYNIYQYISSPEIHVDIKTNDNLADLEPYDGYIISPGPGNPKNSEDRGGLYEFIDRNKEAKFLGVCFGNQILGYYLGSDITLSKRLMHGQPDTISHGDSPLYRDVPEKFTAIRYHSLVLEPGSNIIVDAVSETDGEIMGFHSKDGRFFGVQYHPESYYSEYGKQIFKNFVDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1R6</accession>
    <name>A0A1V0N1R6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="6" type="ORF">FAD_0132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887138.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1R6"/>
    <dbReference type="STRING" id="74969.FAD_0132"/>
    <dbReference type="GeneID" id="16025277"/>
    <dbReference type="GeneID" id="84218621"/>
    <dbReference type="KEGG" id="fai:FAD_0132"/>
    <dbReference type="OrthoDB" id="10538at2157"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="273" mass="30918" checksum="9DA69308E77FBFFC" modified="2017-06-07" version="1">MRLIENWFSERYSDNLQLSFRVKDQLLSVKTDYQRIDLFDTYDFGKLLSIDGTVQLTEKDEYVYHEMITMVPHYFNSRPSNVLIIGGGDGGAARRLLDLGTDKITNVEIDGNVVEIAKKYFPDISSSFKDSRVKLIVGDGIKYIKETENKFDRIIIDSTDPVGPAEGLFSRDFYEDIKAHLTDDGIVVTQSGSPYYQPAALAMAHKGMSEVFKSVKTYCAFIPTYPSGLWSFTMASSGEMKLRDEKAKSGKYFNSDILTGSFYLPEFVKNILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1U6</accession>
    <name>A0A1V0N1U6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative snRNP Sm-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lsm1</name>
        <name evidence="5" type="ORF">FAD_0190</name>
        <name evidence="6" type="ORF">HLB00_05890</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000197">
        <property type="protein sequence ID" value="NOL60363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887195.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1U6"/>
    <dbReference type="STRING" id="74969.FAD_0190"/>
    <dbReference type="GeneID" id="16025337"/>
    <dbReference type="KEGG" id="fai:FAD_0190"/>
    <dbReference type="OrthoDB" id="371816at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01731">
        <property type="entry name" value="archaeal_Sm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022901">
        <property type="entry name" value="snRNP_Sm-like_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="84" mass="9446" checksum="14BDF25C3C3672C6" modified="2017-06-07" version="1">MVNNNRSGYVPKPMETLKNSLEKNIMIDVKGNRMYSGILEGYDIYMNLVLKNATETINNENKGTFSMMLLRGDNIIFVSPPGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1V0</accession>
    <name>A0A1V0N1V0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl4</name>
        <name evidence="7" type="ORF">FAD_0159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887164.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1V0"/>
    <dbReference type="STRING" id="74969.FAD_0159"/>
    <dbReference type="GeneID" id="16025308"/>
    <dbReference type="KEGG" id="fai:FAD_0159"/>
    <dbReference type="OrthoDB" id="10737at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_A">
        <property type="entry name" value="Ribosomal_uL4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019970">
        <property type="entry name" value="Ribosomall_uL4-arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03672">
        <property type="entry name" value="rpl4p_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="256" mass="28160" checksum="87152D68AC1C9D65" modified="2017-06-07" version="1">MKTNVYSIEGEVTKEIELPQVFEIETREDLIHKAFRAISLSMRQPYGSSPLAGTRRVGHNLGPNHGISRIPRLASGSRGVLLASMVGGRSALSPRSDKVLYKKINKKERRLAKLSAIAFTANKERILQRGHRISEESIEKLTFPVVVEDDIESITKVKDAVQVLSNLGVYDDVLRSKDGKKIRAGRGKMRNRTYKQPKSLLIVGSSVESLRAFASLPGVDLASLNSLSITKLAPGGNPGRLTIYTASTIENLREVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1V8</accession>
    <name>A0A1V0N1V8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="7">ATase</shortName>
            <ecNumber evidence="7">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="7">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purF</name>
        <name evidence="13" type="ORF">FAD_0188</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7 10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7 11">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1V8"/>
    <dbReference type="STRING" id="74969.FAD_0188"/>
    <dbReference type="KEGG" id="fai:FAD_0188"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7 9">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD84118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="465" mass="51449" checksum="C0837F1BE35EF74C" modified="2017-06-07" version="1">MDFHPPELDITTGQKPSEECAVVGYIGNNAYTNIIFALRALQHRGQESSGIATFDGKIHIKKGMGFVSEVFRDEFLEGRIGIGHNRYSTAGSKGVENAGPFVISSSMGYIGISHNGEVTNAHDLREKLKEKGYIFYSSSDTEVMLTEIVSEINKYGIRDGIKKAMLKIKGAYALAILINDTLYALRDPFGFRPLILGKNNDGYIVASESAAIDTVSGKVIRDVKPGELIEIRETGYRSIFTIEHKKSHCMFEYVYFARPDSIIDGREVFDVRYNIGVRLATENPVNADVVVPVPDSGRSQALGYSVYSKIPYSEGLIKNRYSDRTFILPDQESRYNAIKIKLNTIKSVINGKRVVLVDDSIVRGNTMRHIIGILRKDGATEVHVRVGSPPIIAPCYFGVDMKTKDDFIANNNSIEDIRKEIGADSLAYISIEGLKESIGMNELCLGCLTGIYPDDIPEGAKPNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1W5</accession>
    <name>A0A1V0N1W5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component 1</fullName>
            <shortName evidence="6">RNase P component 1</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rpp29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnp1</name>
        <name evidence="7" type="ORF">FAD_0167</name>
        <name evidence="8" type="ORF">HLB00_02255</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000069">
        <property type="protein sequence ID" value="NOL59656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887172.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1W5"/>
    <dbReference type="STRING" id="74969.FAD_0167"/>
    <dbReference type="GeneID" id="16025316"/>
    <dbReference type="KEGG" id="fai:FAD_0167"/>
    <dbReference type="OrthoDB" id="39019at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="100" mass="11543" checksum="CAAA10F92F4568AE" modified="2017-06-07" version="1">MNANEVYLMEFIGKNITVKNSHNIKNVGIKGKLIDETKNMMYIWNGSKICSIQKSGTIFGIEFNEGAHYDINGDAILIKPEDRTKEKRKIYKKLRGYESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Y6</accession>
    <name>A0A1V0N1Y6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytidine monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_0185</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylate kinase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141389.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Y6"/>
    <dbReference type="STRING" id="74969.FAD_0185"/>
    <dbReference type="GeneID" id="84218674"/>
    <dbReference type="KEGG" id="fai:FAD_0185"/>
    <dbReference type="OrthoDB" id="31096at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011892">
        <property type="entry name" value="Cyt_kin_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02173">
        <property type="entry name" value="cyt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13189">
        <property type="entry name" value="Cytidylate_kin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD84115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="180" mass="20986" checksum="38FC8B89DCE2B134" modified="2017-06-07" version="1">MIITISGESGSGKTTVGKLLASSLNYKFFSGGYFFRKKAEEYNMDLIDFSNYAEHHPEIDKEEDRMIVEFMQHNDNIILESRLSGYMAYKNNINAIKIYLNTDIATRVDRLASRDKGVDRAGIMTRARSEFLRYMIFYGIDYRVFTNYDYIIDTDHISPENIVNDIVDFYNKFEPDKNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N207</accession>
    <name>A0A1V0N207_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141421.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N207"/>
    <dbReference type="STRING" id="74969.FAD_0228"/>
    <dbReference type="GeneID" id="31675737"/>
    <dbReference type="KEGG" id="fai:FAD_0228"/>
    <dbReference type="OrthoDB" id="377754at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="472" mass="50675" checksum="948010E846162D8A" modified="2017-06-07" version="1">MADNLKRNILGTNRLVWQGWGMTAPAADIAYLLGGIALVALGATPLSILVGFLIYLTILNTSYRFSSKYVSAGSDFTYVGKSIGGFMATFEGWNLLFGTIFAYAGFGMLGLAGFFGIFDSKILTGGLWIPIVLALNVITFIILYKGIRFSTNYQIITGIAEFIILIAGGIGLVILAGKNNTLAVFSPFIASGGIIGFAHSLTLSVVTFIGLSIALTAISEEAHIPKKTVPKSLLISSIIIGVTIVFLSYAMTVAWGPSRMLSFGNSVDNGLVLFRELSPIMFGLLFIFTVNSFMGNNISMGTSMTRIFYAFSRDNIIFPGIFSRTDKNGTPVYTTIFILAISVFLCMVFGIYFGPIDGGYVLLFADAFFSFLIRSISSSSLIISTFKAGKINKKTLTGYLIAPVISIVALIAVLASNFFPLPAYPYNFASVLGIVIIVVVLAITLITWIKRPDTVKNAGSTTVEETPADAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N212</accession>
    <name>A0A1V0N212_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit Rpo1N</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit A'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rpo1N</name>
        <name evidence="13" type="synonym">rpoA1</name>
        <name evidence="16" type="ORF">FAD_0206</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds at least 2 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887209.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N212"/>
    <dbReference type="STRING" id="74969.FAD_0206"/>
    <dbReference type="GeneID" id="16025352"/>
    <dbReference type="GeneID" id="31675716"/>
    <dbReference type="KEGG" id="fai:FAD_0206"/>
    <dbReference type="OrthoDB" id="371812at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02582">
        <property type="entry name" value="RNAP_archeal_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00863">
        <property type="entry name" value="RNApol_arch_Rpo1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012758">
        <property type="entry name" value="RPO1N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02390">
        <property type="entry name" value="RNA_pol_rpoA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF32">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 13 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="207"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD84134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="887" mass="99591" checksum="A8C1974B4A87392A" modified="2017-06-07" version="1">MNFNNVSKRIEKIKFALLSPDEIRKMSQIRVITPDTYDDDGYPIERGLMDLHMGVIEPGLKCATCGGKVDECPGHFGHIELAMPVVHIGFIKEIKTMLDASCKECGRIKLTDDEINNYRTQISSVDFETTDPEIIDMTLKKILDVAIQRNICPHCSSESPKVILDKPTTFREGGIKITPKEIRERLERIPDNDLLFFGINSTAARPEWMILTVLPVPPIDVRPSITLETGERSEDDLTHKLVDIIRISQRLRESRDNGSPQLIIEDLWDLLQYHITTYFDNQTAGIPPARHRSGRALKTLVQRLKGKEGRFRANLSGKRVNFSSRSVISPEPFLSMNEVGIPEVAARELTVPVLINSFNIDKMKEWIKRGTAPRTPDGKYLAGINYLIRPDGRRIKLTDQNAEINSDRIDIGWTVERQMTEGDIVLFNRQPSLHRMSMMAHAVRVLPGMTFRFNLSDCTPYNADFDGDEMNLHVIQSEESRAEARIIMKVQEQIMSPRFGGPIIGAIHDHITSLFLLTHNNPLISEDDTLHTVSYIEFDRLPEPVIKDGKKYYHGRDIFSLILPEGLNVKFKSHLCAGAKDKCEYEDDPADTYVVITDGKLVHGTIDDEAVGPFSGVIVDKIFRNIGPQAAAKFIDSVTRLAVGFLSHRGFSTGIKDYDIPKDAISRIQEISNETLEKIEKLVDAFRSGQLQPLPGRSVEDTLEVEILSSTGGVRDESGKIASQYLGLNDPSVIMARSGARAKMLNIAEVAGMVGQQSVRGGRLNRGYANRTLSHFKENDLGAYARGFIKSSYRAGLNPTEYFFHSIGGREGLVDIAVRTSRSGYMQRRLINAFEDLKVNETRRVEDTIGSVVQFKYGEDGIDPTRSDEGQTVDVDYAAYDEFGDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N219</accession>
    <name>A0A1V0N219_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_0249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N219"/>
    <dbReference type="STRING" id="74969.FAD_0249"/>
    <dbReference type="KEGG" id="fai:FAD_0249"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="156"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="230" mass="26221" checksum="829AD88F80662EC4" modified="2017-06-07" version="1">MIFLVNRISNKPTDEFHSYGFHRVEALLNITIITLFIAISAYSAILTTELLIHGIPISSGSTALSAIIAIPLLIVAGVTIEHDEKSNFRIMFIHTLQDLAIMIIVLAFSLLPFYFFSQYLDYLGSYIVLFIILYGNRNMFRRNVNILLEGSSVSVKEVEEMIRKEFPSVHHLHIWDICQHQRVATLHMSIPSQMQIGELDSVRKDIERILSKYGVNHVTVQFESNNGDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N230</accession>
    <name>A0A1V0N230_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA small subunit methyltransferase Nep1</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">16S rRNA (pseudouridine-N1-)-methyltransferase Nep1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nep1</name>
        <name evidence="10" type="ORF">FAD_0243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a pseudouridine in rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46696"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:13933"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887260.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N230"/>
    <dbReference type="STRING" id="74969.FAD_0243"/>
    <dbReference type="GeneID" id="16025406"/>
    <dbReference type="KEGG" id="fai:FAD_0243"/>
    <dbReference type="OrthoDB" id="7612at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00554">
        <property type="entry name" value="NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023503">
        <property type="entry name" value="Ribosome_NEP1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="196"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="9">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes Arg-xx" evidence="9">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="9">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="222" mass="25626" checksum="16C7DC874F69131F" modified="2017-06-07" version="1">MLRLIIADAELQTVPEKMAKDRSIRNIAEKNHKNPAEMLLDSNYMHTTIEKFYPGESNRRGRPDIIYIFLEMAMESILNKNNMLDVYVHTRDNFIIHINNQTKLPRSYNRFQGLMEDLFKKRSIEYNGNELLSMEEGKIIPFLKNLDGKTVVLSPDGKESSLSGIINDNDLNVVIGGFSQGDFISDLYGNFPSYKIFREELTIWSVGMEIISQYERFTSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2A3</accession>
    <name>A0A1V0N2A3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0302</name>
        <name evidence="4" type="ORF">HLB00_04275</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000147">
        <property type="protein sequence ID" value="NOL60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141472.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2A3"/>
    <dbReference type="STRING" id="74969.FAD_0302"/>
    <dbReference type="GeneID" id="84218802"/>
    <dbReference type="KEGG" id="fai:FAD_0302"/>
    <dbReference type="OrthoDB" id="38408at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.240">
        <property type="entry name" value="Methylmalonyl-CoA mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF1">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="Cobalamin (vitamin B12)-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylmalonyl-CoA mutase alpha/beta chain catalytic" evidence="2">
        <location>
            <begin position="46"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="567" mass="64853" checksum="DDC6F2F9BEDA063D" modified="2017-06-07" version="1">MENFWDLKIKEIKGSFKEDKNYEEWKKTILEPWNKKTGYRDKIRTNSSSMPVKELYTRGDLPDNIDSILGNPGEYPFTRGVYPNMYRGRNWTMRMFSGFGTPDDTNKRLKYLIENGETGLSIAFDMPTLYGFDCDNKRAEGEVGKCGVNVSSLHDMERIFDGIDLSKVSTSMTINAPAAILTAMYFVLAEEKGIPLEKIAGTVQADILKEYIAQKEWMYPPEAHLRLIRDMLTYSTEHVPKWNYISVSGYHIREAGSSAVQELAFTLADGFYYIEMGMNAGLNVDDFAPRMSFFFNSSINFFEEIAKFRAARRIWATVLKEKYHAKNPRSMELKFHTQTSGYTLTWQQPLNNIVRTTIEAMAAVLGGTQSLHTNSYDEAWALPTDDAVKVALRTQQIIAEETGIADVIDPLGGSYYLERLTCEMEIEAYKYFSEIEKMGGILDAVKSGYIQKEIADTSYKKQLKIENEDDIIVGVNRYVDKDEKPINTLKITDIAENGQINSLKNIKSKRDESKVAESLEKLKNAMEDESVNLMPYIMDCVRNYCTLEEISNIGRDIFGEWKEPKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2A4</accession>
    <name>A0A1V0N2A4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aminopeptidase</fullName>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FAD_0317</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141496.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2A4"/>
    <dbReference type="STRING" id="74969.FAD_0317"/>
    <dbReference type="GeneID" id="31675826"/>
    <dbReference type="KEGG" id="fai:FAD_0317"/>
    <dbReference type="OrthoDB" id="139771at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 14 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="15">
        <location>
            <begin position="200"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="16">
        <location>
            <begin position="483"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ARD84239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="787" mass="90450" checksum="FBDA6D2BBF08D741" modified="2017-06-07" version="1">MRVVNYNIKLDIDFSGKKYSGIEKIKITDAEKKITLDLNKIDIHKIKVNGSDVKFEAGEDGVTFPTDGGDIVAEVQFSSDNDRGLKGFYVAGTEKEYILSTQFEESDARRAFPCIDNPNYKATFDITMAIDKDLQAISNMPVKFETLENSKKVVQFEQTPVMATYLVYLGVGHFDEMEDKYRGKRLALTAMKGHLTESRYPIDCAKKSLEYLENYTGIDYMLPKLNLISVPEFAAGAMENWGAITFREILLNIDKSTTSRSYKRTAEVITHELVHMWFGDLVTMKWWNDLWLNESFATFFAFKTVDSTNPDWKFFGDFLLDQTDGAYTMDALKNSHPINADVTDPRSISQLSYEIRYGKGSNVLRMIEAYVGKDVFMKAMRNYLKEFSYSNASGSDLWNAIEKESGKGISTIMEQWISQKGYPYLETAKDGDSLKISQKQFYFLEGDKNSSWKIPLFINRFSSEEKLLMEGNEMKLDGDILSLNFNHNGFYRVLYDDSMFENISRNLSQITAEEKWGLANDLYAFLLSGKINITTYVRRLEKLYGINENIVIDEISKELFNLYTITDNNYFRDLANFYIKDKMEYVEANRKDDFNFKITLSGLYTKLAYINNDFCKSLLKKYSSYENVDPDFRLGYLVAEAKINQDFSYFADIITNTKNDEDKTKAITASGALEGNKNHRAIMEFVKSGKAKKQDMDSFFVAMASNAPSRQFIIDNLKDIVDMLYKFELSPLRINRCVQSMIGNAGVKEPEKMRKNTDSIKRDELFGGINKGLEFLEVYENLIKNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2E8</accession>
    <name>A0A1V0N2E8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141520.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2E8"/>
    <dbReference type="STRING" id="74969.FAD_0345"/>
    <dbReference type="GeneID" id="31675854"/>
    <dbReference type="KEGG" id="fai:FAD_0345"/>
    <dbReference type="OrthoDB" id="56663at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045427">
        <property type="entry name" value="MoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050513">
        <property type="entry name" value="RavA_ATPases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32204">
        <property type="entry name" value="ATPASE RAVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32204:SF0">
        <property type="entry name" value="ATPASE RAVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20030">
        <property type="entry name" value="bpMoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="388" mass="44039" checksum="606E20520C9CA0C2" modified="2017-06-07" version="1">MKNINKIFEVKNYLTDTFVGREDVINGVLAGLISGEPTLLVGPPGTAKTSIIDTMSKLINARYFYYLLTKFTEPEELLGPIDITALKNGEYRNITKGKLPDANIVFLDEIFKSSSAIRNTLLDIMLNRRLPNGGTMINLDLLGIYSASNEISDDEEDMALYDRYPIKIFHRYVERTILKDLLDKGISMESGKTMEKPLLDTGEVVMLQSEAVRRMDTLRSTDNDVIDRYMEAIFQLEENDVILSDRRKIKLLKIAAAFSMLMDSKTITGNDVAMAMRYSADSEDYIPKIEAAIIDSKLENKSDIVQKAETTMEETKSLIQSTENAINRNSPYNVVLDQLSLLEIYIKKLERMKFELGSDNSPYHKDIVNRINTSLEFAGSRYEKLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2H8</accession>
    <name>A0A1V0N2H8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="5">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2H8"/>
    <dbReference type="STRING" id="74969.FAD_0437"/>
    <dbReference type="KEGG" id="fai:FAD_0437"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="7">
        <location>
            <begin position="176"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="207"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="NCBIfam" id="TIGR00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="409" mass="44927" checksum="33FC89F922E60549" modified="2017-06-07" version="1">MTDNNGFLRLKWARDHMPVCANIRERFLKEKPFKGIKIAMALHVEAKTGIFALLLTEGGAEVRLASCNPLSSDDSVVQSLSKDYNYMVYAKKGESEKEYYENINKTIEAAPDIIIDDGGDLTNLVASKPELVKKVIGGNEETTTGVVRLKAMEKAGALKFPMFDVNDAQMKHFFDNRYGSGQSALDGFMNATNILIAGKNALVAGYGYVGKGVAMRLKGMGARVTVTEVDPVKAIEAVMDGFTVDTMNSAIRYCDLIFTATGMKNVVSYDDMLVAKKGIIMGNVGHFNNEIDYSSLEKKNIGKTPVRNLVTEYKLENGNTVNLISDGRLLNLAAGQGHPVEIMDLSFALQALTAEYIVKNKGKLSNKVYPVPAEIDTEVAKIALESLNFKIDTYTEEQLKYLDSYQEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2I1</accession>
    <name>A0A1V0N2I1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Lipid exporter family ATPase and permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0414</name>
        <name evidence="11" type="ORF">HLB00_04995</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2I1"/>
    <dbReference type="STRING" id="74969.FAD_0414"/>
    <dbReference type="KEGG" id="fai:FAD_0414"/>
    <dbReference type="OrthoDB" id="121502at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="333"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL60192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="569" mass="63955" checksum="27784B778128BE88" modified="2017-06-07" version="1">MNNYFIRLLKEILAYKRNSTIIISAILASSVIAMIGPYIIGIATDSIIALKFKILIILAVLYLGIYIINYIAENRRTKYMMNTSQAVIKGLRDRAFRNLQYVPLKYYAGKNAGQIISRITNDAETLSDFLTFQLPQVVAGIAGIIASIFIMIYLDPLLTVYAVIIIPMLLATVFLMNKRIKFNYMNVRRRIAELTGNVGESINGVKAIKSSGTEDVFNDNFETVNSNNYEANIRAVRLTSLFSSIVQIIEGLGIMIVLYEGGAEVFGRVISIGILVSFIVYVQSFFNPIVQLSQFYNSYQSSSIAIERIYRIIDEENDYTTNGSNIPAFTDKLKFNNVTFSYGKERIIDNLSMVIEKGKRIAIIGKTGAGKTTISNLILNFYKPDTGTITMDGVDINNFNTMEYRKLFGVILQDPFLFDGTILENIRFADYSIPEEEIKEKISSLGLDSIIGPLGLYANVGERGSNLSEGQRQAVSILRAAVNNPQIIIMDEATSQLDMKNESIIQSAIFKFMEGKTIIIIAHHLQTIIHSDYIYYIDRGKTLEEGEPDMLMGEGTRFYDLYIKNKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2I9</accession>
    <name>A0A1V0N2I9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine phosphatase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase/fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0425</name>
        <name evidence="4" type="ORF">HLB00_04905</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000166">
        <property type="protein sequence ID" value="NOL60175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887481.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2I9"/>
    <dbReference type="STRING" id="74969.FAD_0425"/>
    <dbReference type="GeneID" id="16025627"/>
    <dbReference type="KEGG" id="fai:FAD_0425"/>
    <dbReference type="OrthoDB" id="304253at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054929">
        <property type="entry name" value="dPGM_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038349">
        <property type="entry name" value="dPGM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="189" mass="21508" checksum="11F14C8F8D2BD0DC" modified="2017-06-07" version="1">MKYVILIRHGESYTNRNGILSSELNRYRLTEEGIEQARFTGEQLNGLKFDGIISSPILRAVETANIINQYLNLEIKTDNRAIESDFGEYNGKRIVDIPDKSRDELGMESFESQTSRMIDLINSYTGNYIVVSHSFPIRCVLANYLKLGEIESFGLDIRHASMSVINVEKEKILAIGSLLLSPEIRKIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2K1</accession>
    <name>A0A1V0N2K1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0453</name>
        <name evidence="2" type="ORF">HLB00_10040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000442">
        <property type="protein sequence ID" value="NOL61157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143139.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2K1"/>
    <dbReference type="STRING" id="74969.FAD_0453"/>
    <dbReference type="GeneID" id="84217036"/>
    <dbReference type="KEGG" id="fai:FAD_0453"/>
    <dbReference type="OrthoDB" id="56523at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL61157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="298" mass="33796" checksum="CF88ECF72927C68F" modified="2017-06-07" version="1">MAYTKRENSYWLFSRELKDSTKLEGEEKRPYVITPLGTKVKRILFAGAITYKNSDDRMVKVTVADYIGSFYLTAFKTGFSSEMAEELDKFNVNDIVMVMGKVSSFKTDDGIFYFSVNPELIKSIGETERYFWGVRASYVAKRKILAITEAIKDDVATVDTLLKLGYSQDEAEDAIRAKEYYTDYDFKSYMDAISSINFDSPVMAVAHREMDIENPESFETEGNSSNQQNTGAPQTFNIEEFVLAYIKNNDSGPGCKYDDIIISCSNAGISREKVDEILNSLGSRGEIYEVSLKRYKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2K9</accession>
    <name>A0A1V0N2K9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="7">UPD</shortName>
            <shortName evidence="7">URO-D</shortName>
            <ecNumber evidence="3 7 8">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemE</name>
        <name evidence="12" type="ORF">FAD_0463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141617.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2K9"/>
    <dbReference type="STRING" id="74969.FAD_0463"/>
    <dbReference type="GeneID" id="31675972"/>
    <dbReference type="KEGG" id="fai:FAD_0463"/>
    <dbReference type="OrthoDB" id="124836at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 7 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="11">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="22"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="335" mass="38028" checksum="C59BF0406E61CBFE" modified="2017-06-07" version="1">MNNFIPALKQEPHDHIPVWFMRQAGRYMDEYKELRKLYNIRQMCMDPEITEKITYAPVKLLGVDAAIIFADIILPLEAMGYKIDFNSSGPDIGNGYRHNKSMEGIHEFNTGDLKYRTYDAIRLFKQNYPETPLIGFSGGIITVMSYIIAGVSDNNLVYTKKVMLNDPSFGIMKKMIKNMILDYVTMQVKAGVDAIQIFDSWLGALSPYTFEKYLKNDIIELVESIKSKVPVIYFSTGSSGMIEQFNDIKPDILSVDWRIKLSHARTILNGSIGMQGNLDPYLVQYSREAALEETGRILGEAGKDDNYIFNLGHGVLPETDPDTLKSITDTVHSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2M0</accession>
    <name>A0A1V0N2M0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="13" type="ORF">FAD_0473</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141625.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2M0"/>
    <dbReference type="STRING" id="74969.FAD_0473"/>
    <dbReference type="GeneID" id="31675982"/>
    <dbReference type="KEGG" id="fai:FAD_0473"/>
    <dbReference type="OrthoDB" id="372178at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="287"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD84388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="485" mass="56657" checksum="7F717FAB2C3FDE08" modified="2017-06-07" version="1">MEKNEISPNEYKVLNFIKNRSDVPEEDIDVDTDRRIVSSSISYLEFKNLINVNKVTEESVSITEEGKKYIENGFPEEKLYNFLAKHEKCSMKEVVDYMGSDYKIAIANTAKLGIKPANGEMALHGEKLDDIFRNKRMELSGISNGKIPDKVTLDEFLHRGLAAKRKYTKRIININESGKEALESYGKDDYFEMLTPSLIASGKWRDAKFRPYDLNSRVEPLNGAGLHPLTYLIEKVRKIFLEMGFTEMHGHFIEYTGWNMDMLFIPQDHPARDLQDTYYVESKNPVEFENPEILDKVKRVHEHGYGKYSGWNYKWSEDEAKKLILRTHTTVNTIRYLYNHRDKPQYIFSIEKVFRHESVDWKHLSELYQIEGAVYGSDVNLSTLKWLLTEFYSRLGFKNIRLIPSYYPYTEPSMDVAVDINGKEVELGGSGIFRPEVTKPMELKEPVLAFGLGLERLAMLYYNFNDIREIYNSDLDWLKNYKIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2N0</accession>
    <name>A0A1V0N2N0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylaminoadipate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysZ</name>
        <name evidence="9" type="ORF">FAD_0506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141640.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2N0"/>
    <dbReference type="STRING" id="74969.FAD_0506"/>
    <dbReference type="GeneID" id="31676014"/>
    <dbReference type="KEGG" id="fai:FAD_0506"/>
    <dbReference type="OrthoDB" id="6816at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04251">
        <property type="entry name" value="AAK_NAGK-UC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010662">
        <property type="entry name" value="PRK14058.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="254" mass="27988" checksum="F3FF2167CC158371" modified="2017-06-07" version="1">MKVLKIGGSVLDNFLENDNLYSIIQQFDCPLAIVHGGGNYLDTHADSFNYTKKFVTSPEGIRSRYTDKNTLEIFTMVMNLINQKLVLNLKEHGIKAVTLNGIINARRKEKLIIMNEKNRKMIIDGGYTGRVESADSIPIRAVIDEGYIPVISPVAYGNGNYLNVDADRAAAYVAGSMGSDSLVFLTNVSGLYYKDRVIEKADVAYIKSILNEIGTGMDKKLMASIEALEMGVKQVTISNPFNGISTGTVIYNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2R1</accession>
    <name>A0A1V0N2R1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="1">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141610.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2R1"/>
    <dbReference type="STRING" id="74969.FAD_0451"/>
    <dbReference type="GeneID" id="31675960"/>
    <dbReference type="KEGG" id="fai:FAD_0451"/>
    <dbReference type="OrthoDB" id="371967at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000224">
        <property type="entry name" value="Probable glycine dehydrogenase (decarboxylating) subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="5">
        <location>
            <begin position="151"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="346"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="477" mass="53284" checksum="CAC587E32153D536" modified="2017-06-07" version="1">MYRQAYYDEDFLNQFNTGNDFYMDDVEDSYPESIRRKSLKLPDVRSVDVSRHFTRLSEMNYSVDLGMYPLGSCTMKFNPKYANYAASLPDFRDIHPMESQLKTQGTLEVMYNMQQFLVKISGMDYATLQPSAGAHGELTGILIVRKYFETRGEIDKRNEIIIPDSAHGTNPASAVMAGFKVVEVPSNENGLVDLEALKAAVNENTAAFMITNPNTLGIFDDQISEIATIIHNNGSLLYYDGANFNAILGITTPGKMGFDIVHFNLHKTFATPHGGGGPGAGPVAVKSFLMDFLPVPIVVNDKGTYSLFYGLKNTIGKVSSYNGSFGVVLRAFSYVLKNGNNLSANAKRAVMNSNYMAKKLSKYYKIPYKQLKKHEFVLSTENTGRKALDISKFILDYGIHSPTTYFPLIVKEAMMIEPTESVTKKDMDYYIDVMEKALSVPEEELKQSPVNTSVHRIDEIGAARNLILKWPAPTENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2S8</accession>
    <name>A0A1V0N2S8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxypeptidase G2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141631.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2S8"/>
    <dbReference type="STRING" id="74969.FAD_0491"/>
    <dbReference type="GeneID" id="31676000"/>
    <dbReference type="KEGG" id="fai:FAD_0491"/>
    <dbReference type="OrthoDB" id="24854at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03885">
        <property type="entry name" value="M20_CPDG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017150">
        <property type="entry name" value="Pept_M20_glutamate_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF9">
        <property type="entry name" value="BLL0789 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037238">
        <property type="entry name" value="Carboxypeptidase_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="179"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="376" mass="41617" checksum="B97251E979BC3250" modified="2017-06-07" version="1">MNNVFQYFKSQQDSMLSDLKSLVEMETPSTDKVLLDKFAGYMAGYLKENLGIAPEIIKSESAGNDLRLAIKGKSDNRILLLCHYDTVFPEGTIKSRPFKVENGKGYGPGIFDMKTGLVQTVYALKALVKNKELKYSIVLLITSDEEIESGSSKDLIISEAKKSIFTFVMEPSLDGALKTERSGVGTITLKIYGKASHAGLEPEKGINAIYEMAYMIPVIEKLNDKQKGTSINLDVINGGTRSNVIPDYCEGIMDIRYKLPEESERIIEALENTPLRFHGSRKELEYKLRPPLVKSEDSKELFLKVREIGENLGLDLDEASVAGGSDGNFCSYYCPVIDGLGAVGAGAHSENEYIVVDKIPERTALLYLALKDINWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2T0</accession>
    <name>A0A1V0N2T0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR-2 group transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0485</name>
        <name evidence="4" type="ORF">HLB00_08810</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000332">
        <property type="protein sequence ID" value="NOL60920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887541.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2T0"/>
    <dbReference type="STRING" id="74969.FAD_0485"/>
    <dbReference type="GeneID" id="16025688"/>
    <dbReference type="KEGG" id="fai:FAD_0485"/>
    <dbReference type="OrthoDB" id="85590at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055767">
        <property type="entry name" value="DUF7343"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24034">
        <property type="entry name" value="DUF7343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7343" evidence="2">
        <location>
            <begin position="96"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="158" mass="17670" checksum="3F3F721A53CA668F" modified="2017-06-07" version="1">MSVKNNNFKIIIIIAIYATISSIIASSVMIVIELLGLKILLLYIISYAIIMATDIAILYYAIEIIMERYTKMLKIINEPVANAPRPGVERKAIELTDSESAIVSILEKNNGRIMQNSLTGKTGYSAPTISRILTTLEEKGVIDRRRHGMTNEISLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2U6</accession>
    <name>A0A1V0N2U6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2U6"/>
    <dbReference type="STRING" id="74969.FAD_0482"/>
    <dbReference type="KEGG" id="fai:FAD_0482"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="208" mass="24324" checksum="CBEA2D31FFD39AEA" modified="2017-06-07" version="1">MRQQGDIVDELDELRNKAIELLLNVDIIRDCTYVNRDDFEQGTLEYEDLDYQDKNMLFTIDDFTVLNLKGDKNHVDKLIINFNGIHGDDPENFDDVDFYMEKYSDILEKNNNVSLINIIPLRTNRKETFLALFDRTEFNGIITFDYIINTLFKSYILPVINIIKPGEVLILDSRLKNSIKNVLESDTSIDVPPVSMFDDISSYRENYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2V5</accession>
    <name>A0A1V0N2V5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">tyrS</name>
        <name evidence="10" type="ORF">FAD_0556</name>
        <name evidence="11" type="ORF">HLB00_00720</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000020">
        <property type="protein sequence ID" value="NOL59362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141685.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2V5"/>
    <dbReference type="STRING" id="74969.FAD_0556"/>
    <dbReference type="GeneID" id="84217155"/>
    <dbReference type="KEGG" id="fai:FAD_0556"/>
    <dbReference type="OrthoDB" id="8389at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02009">
        <property type="entry name" value="Tyr_tRNA_synth_type4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023678">
        <property type="entry name" value="Tyr-tRNA-ligase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="219"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL59362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="329" mass="37216" checksum="600D2186B94AC006" modified="2017-06-07" version="1">MENTVILKKNTAEVVTLEECKDLVPDNSEAYIGFEPSGLPHIAILIYVNKINELVKLGFNVKVLLADWHARVNDKLGGDIDLIRKSGETLRKSMLYAGLLDGVQFIWATDLVANPDYWELLLQTAKNSSLLRIRRSLPIMGRTEEDADKDFSKYIYPLMQVTDVFYLNSDIAIGGTDQRHAYMLARDIAEKMGRKKPILVEMPLISSLKGKGRMDDFKKMSKSDPDSALFLTDSEDDIRRKIKNAFCPMGIVDGNPVIDIMKYVIFPYYATEIEINRPESHGGPYTIHSFGELESKYLNSEIHPMDLKKALTQILINVILPVSNKLNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2V7</accession>
    <name>A0A1V0N2V7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="16">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">kdpB</name>
        <name evidence="18" type="ORF">FAD_0517</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>K(+)(out) + ATP + H2O = K(+)(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="16"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887575.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2V7"/>
    <dbReference type="STRING" id="74969.FAD_0517"/>
    <dbReference type="GeneID" id="16025721"/>
    <dbReference type="KEGG" id="fai:FAD_0517"/>
    <dbReference type="OrthoDB" id="8588at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743:SF1">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 16" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="129"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="388"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ARD84431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="720" mass="77389" checksum="019D4DA269C4C15B" modified="2017-06-07" version="1">MLFNKNKNFEGKKESGNPEGHISWAFIIKDSILRMNPARLIGNPVMFVVELSFFVVLLMAIVPGAFPHLAHQSSRMFYADVAAILLITVWFSTVSDSFAEARSRVTTASLKKLEKEGIAKRIKEDEGSGRTIESVKSSELRKGDVILIEKGDQVPIDAEVTEGIAMVDESLLTGESAGVKKSKGDTVIGGSTVISDSIVAIVNVNPDETYISKLVKMVESSERPKTPNELALSILLIGLTGVFTIILISLIAFSLLLNLGADLSVLIALYVCLLPTTIGALLPAIGISGITRMSKNNIIAKSGKAIETAGDTDTILLDKTGTITVGNRLAYEFIPLGTHTERELAEAAFLSSWNDDTPEGKSILELAYKKKFVPREYDALREGVQEEFSAVTRKSGITLTDADDFTLLKGGRDILQRHRFRRKFELQTPMTQETTIQKGAPESIKESAKICPDGYDDVVTRITSEGGTPISVSMDGDILGIIYFKDVIKRGIKEKILGLKTMGIRPVMITGDHPLTAKNIAGEVGIEDYVAQAKPETKYQKVKDEQAENRIVAMIGDGTNDAPALAAADVGLAMASGTLAAKDAANMVDLESNPSKIIDVVMLGKQLLMTRGTITTFSITNDVAKYFAIVPIMFASIPALGALNILGLSPHIAVLSALIFNAAVIPALIPLALRGTTFKPQSTLKLFLKNLVIYGGGGVLLPFAGIKLIAIVLVFLGGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2W2</accession>
    <name>A0A1V0N2W2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein eL8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl7ae</name>
        <name evidence="11" type="ORF">FAD_0589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit. Probably part of the RNase P complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2W2"/>
    <dbReference type="STRING" id="74969.FAD_0589"/>
    <dbReference type="KEGG" id="fai:FAD_0589"/>
    <dbReference type="OrthoDB" id="25810at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00326">
        <property type="entry name" value="Ribosomal_eL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_eL8_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="10">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="193" mass="21312" checksum="AAF6AEA944240087" modified="2017-06-07" version="1">MENSYVKFEAPESLVKDALDFVENSYRSGKIKKGTNEVVKSIERGEAKVVVIAEDVSPPEVVFYIPVLCEERKVPYTYVKNKSDLGLKVGIASAASIAVVDFGKNEDAYKELISSIENAKAGKEEKKKPAAKSEKPKEEAVEAEAAEAPEAEKEAKKEAKKEPKKAKTSESKETKKAPKKTTKKKEDSEEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2W9</accession>
    <name>A0A1V0N2W9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">grpE</name>
        <name evidence="5" type="ORF">FAD_0532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887589.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2W9"/>
    <dbReference type="STRING" id="74969.FAD_0532"/>
    <dbReference type="GeneID" id="16025738"/>
    <dbReference type="KEGG" id="fai:FAD_0532"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="170" mass="19862" checksum="8E7A961FE33E33E1" modified="2017-06-07" version="1">MNHKEYNRPLEFDIEQVRKRNKMKDREEMKKYKQLYTDTMSDLNDYKSLYVRQRSEMENYSKYKEREIENIRKNASSDLIKELLPVLDTLDAGIAHDPKLEPVRSQLLKVLQSHGLQVLEVKGTKYDPNLEEAVGVLDQGEDGTVLEEVQKGYTLNGDVLRTSKVIVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2X2</accession>
    <name>A0A1V0N2X2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2X2"/>
    <dbReference type="STRING" id="74969.FAD_0523"/>
    <dbReference type="KEGG" id="fai:FAD_0523"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="83" mass="9982" checksum="6C2E17CBF0F72240" modified="2017-06-07" version="1">MIYIIIRREISKYLVTKISCDHMFDKIERLDDNEVIIDFLLVYYISNEFIDAYIANRHMSMKHIVEKNIPLSMKKLLSQQSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N331</accession>
    <name>A0A1V0N331_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0660</name>
        <name evidence="10" type="ORF">HLB00_09925</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000440">
        <property type="protein sequence ID" value="NOL61135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141760.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N331"/>
    <dbReference type="STRING" id="74969.FAD_0660"/>
    <dbReference type="GeneID" id="84217262"/>
    <dbReference type="KEGG" id="fai:FAD_0660"/>
    <dbReference type="OrthoDB" id="44105at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43163">
        <property type="entry name" value="DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43163:SF6">
        <property type="entry name" value="DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="103"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL61135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="343" mass="37606" checksum="FB038DA875A4AE13" modified="2017-06-07" version="1">MNTNLILYIVRRAIYAVVTLIFIIVIVYFLIHLIAPTPDALAGIYAGSGHHTRAEINAIIIKYHLNAPLYTQVLLYIGNVFRGNLGYDPVYHVPEITLIGTFLPRTLELVIPAIIISTLLGLYTGAFGASHRRKIQDQGVKGVYLVTWASPPFFIAIVIQLFLAYDLGLLPSTGMVSPTLIAPPDVAAFPLLNAIIAGDLPYFFSLIQHMILPVLAIALLSFGVITRITRSSMLDSMESDYFKLELMKGISRKSAVYGAALRNASIPIITLLALTFGYAVAGAVVVEDIFDYHGMGWFIVHSIYTLDYIAILSTTVIIAISIIIANLAADILYGVIDPRVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N362</accession>
    <name>A0A1V0N362_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type peptide/opine/nickel family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N362"/>
    <dbReference type="STRING" id="74969.FAD_0686"/>
    <dbReference type="KEGG" id="fai:FAD_0686"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30465">
        <property type="entry name" value="INNER MEMBRANE ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30465:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="25"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="252" mass="27789" checksum="91C4C09AEBED4B80" modified="2017-06-07" version="1">MFSFHFGVSFANMNDSVISLIGSALPYTLIIFGVAAVASFIIGIPLGILTSFLRGKKSESPILVTSTILNSIPFFAMAIIVFLILAVYYPIFPLQVSFYRLTPLFSHPTVSRLITMFYYFAMPILTLVAIEAMGHLLTMRSIMVSVLGEDFITTARAKGVKNSSIMFHHAARNAMVPESTRMALEFALLMSGAVVTEIIFGVPGMGRLLYTNTLDENYPVIQAALFILSIVTIIAYSLVDFIHAWLDPRVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N370</accession>
    <name>A0A1V0N370_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0605</name>
        <name evidence="2" type="ORF">HLB00_10125</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000443">
        <property type="protein sequence ID" value="NOL61174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141721.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N370"/>
    <dbReference type="GeneID" id="31676110"/>
    <dbReference type="KEGG" id="fai:FAD_0605"/>
    <dbReference type="OrthoDB" id="57545at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL61174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="80" mass="9365" checksum="8C79E97D7E72EE60" modified="2017-06-07" version="1">MEILYSNKKAEFGEKEYFIASHEPLYYGLIISPSSDLWSYMVESGKVECKIENEIRKYLIPYRIDVGENSIFFITADPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N374</accession>
    <name>A0A1V0N374_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887756.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N374"/>
    <dbReference type="STRING" id="74969.FAD_0696"/>
    <dbReference type="GeneID" id="16025912"/>
    <dbReference type="GeneID" id="31676198"/>
    <dbReference type="KEGG" id="fai:FAD_0696"/>
    <dbReference type="OrthoDB" id="24596at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009466">
        <property type="entry name" value="PRK12826.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="239" mass="26087" checksum="81570339BF65844B" modified="2017-06-07" version="1">MSGKIVITGSNRGIGRSIAEKMASEKYGIIMVDYDNAVLDSAKSLNSRYGNVEGIKCDVSSYDACVEAFSTIDKKEIYGIVNNAGINRDALFKNMSFDQWDAVIKTDLYSMFNVTKQFVDSMIENLSGRIVNISSASWNGNVGQANYSSAKAGVIGFTKTLSRELGRYNITSNAIVPGFIKTPMTDQMPEKIKEKFIEKIPLKRMGSGDDVANAVSFLMKEDSNYVNGILLEVGGGMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3A9</accession>
    <name>A0A1V0N3A9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type peptide/opine/nickel family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3A9"/>
    <dbReference type="STRING" id="74969.FAD_0687"/>
    <dbReference type="KEGG" id="fai:FAD_0687"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43839">
        <property type="entry name" value="OPPC IN A BINDING PROTEIN-DEPENDENT TRANSPORT SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43839:SF1">
        <property type="entry name" value="OPPC IN A BINDING PROTEIN-DEPENDENT TRANSPORT SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="503"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="709" mass="78016" checksum="6E9038AC04BC5C44" modified="2017-06-07" version="1">MKFTAKNLHKQWKVFYRSRYGKVGFYILMVFIVISLLAPVLVHGNPFAAIPTEDYFSPIQEMNHPLNFTAVNSSYAITSSEYGTSAVSYYLFMPGLANGTYSIYAISPKNASSTYLFHIDGIPENLYAFSVFNSTTGISQENLMVSTNNTIYMGNVVCSYNSLTDSSSVHMSNMIKTRSTNGEILSDYTSSKTYALSDPSIISSQFLTSSPLSYVYTLSENNSKYYVNTFYTSNLTHYWSREISVKPTNLYFYGQEFENPSETRIIITAGDNIYSYNYNGTLEYNEKYNFTLSNLIIPSDYQIYPSHKNDAFTFAGKDVYSINIETGENKVIYSSPQMISALGTSAATTPTEPPSIFMVSTATNVYSLGMNNGNLSVANTIKVPFGVNNIKYYTSGTFLLSNTTSGDIIYLINPSIQYPFSWHASLNRKITAPVLFNNPYPENKSLDNAPAIAVLSGKNLIVYSFEGQAAVLPPTSKTLSGISLPLGANNAGNNVWTIFIDSFPTDLEVGFAAGIITIIISVVVSMVIGYYSGILSSFWETVSLAIFLIPGLPLFIVLATILGPTLINLILIFSLLGWPFVTFSLIGVVRSIKSRVFVESAIVSNLSTTKILRRHILPNMGTLLVYLTSINIGGAVAAVSTYEILGLAPLTIPTWGGMLNGFLGDYYGISKYPWIYVPALLALTLFILAFIFISRGIDEVANPRLGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3D9</accession>
    <name>A0A1V0N3D9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_0718</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
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        <property type="protein sequence ID" value="ARD84624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_081141841.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1V0N3D9"/>
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    <dbReference type="GeneID" id="84217341"/>
    <dbReference type="KEGG" id="fai:FAD_0718"/>
    <dbReference type="OrthoDB" id="2596at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="HAMAP" id="MF_00487">
        <property type="entry name" value="Malate_dehydrog_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
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        <property type="entry name" value="Lactate/malate_DH_N"/>
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        <property type="entry name" value="Malate_DH_type3"/>
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        <property type="entry name" value="MalateDH_bact"/>
        <property type="match status" value="1"/>
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    <dbReference type="NCBIfam" id="NF004863">
        <property type="entry name" value="PRK06223.1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR43128">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
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        <property type="entry name" value="LDH C-terminal domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
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        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="151"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
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            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD84624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="322" mass="34741" checksum="A481D29416D3B444" modified="2017-06-07" version="1">MDKKISIIGAGAVGASVAQVLAIKNIADINIFDIVEGVAEGKALDIQEGAPHFGFDCKLHGFCTQDPKEYANLKGSDVIVVTAGLARRPGMSRDDLLVKNIGIMKDVGEQIKKYSPDSIIVAVTNPADIMAYALQKASGISPERIIGLGGSLDSSRFRTFLAEALNVSVKDVNAFVIGGHGDDMVPFIHYSSVSGIPISDLLSEEKIQEIIKRTRFGGGEILNLYKTGTAFYAPSISISVMVESVINDQHRVIPCAAYLTGKHAENYKVSNAFIGVPIKIGKNGVEEIYDLKFSEADAKEWMKSVESVKKNNKLADDYFASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3E4</accession>
    <name>A0A1V0N3E4_9ARCH</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
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    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
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    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
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    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="9"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="366" mass="40693" checksum="CA4176A8B3784049" modified="2017-06-07" version="1">MNLYEYMGKEIFKKYGIPVPDGYVIENVGELRKFEYPVAIKSQILSGKRGKAGGIKFARNSNELSEFSDKLLNSTINNLTVKKLLIERMLNIKKEIYLSITLDRATKEPVIILSADGGMEIESVPEENIHKIHIDPMVGYSDYIAREALSYIPVENKKQFSNLLSSLYKAFVGEDALLTEINPLVIDSENNIIAGDSKVIIDDNALYRHKDYMITDPDKTALENEAASKSFTFIEMDGDIGVIANGAGLTMATMDSLTLHKLKPRNFLDLGGTDNIEIVEDAFSFVMRARPKLIFVNIFGGVTKADTVANGIVSSKKKFDIKQPIVVRLSGVHEEEGQKILLESGIKAFTNMTDAVKELSRIQGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3I2</accession>
    <name>A0A1V0N3I2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142006.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3I2"/>
    <dbReference type="STRING" id="74969.FAD_0812"/>
    <dbReference type="GeneID" id="84217434"/>
    <dbReference type="KEGG" id="fai:FAD_0812"/>
    <dbReference type="OrthoDB" id="9287at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05403">
        <property type="entry name" value="NT_KNTase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43449">
        <property type="entry name" value="NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43449:SF1">
        <property type="entry name" value="POLYMERASE BETA NUCLEOTIDYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="118" mass="13380" checksum="0273C25A27D04E2B" modified="2017-06-07" version="1">MEIIEKRIKERNSVINQSGEYAKTLDFKCTVILIGSYARGDFNLWSDIDILIIGHFDANPLKRLKNIDFPAGYETVLLTPDEIKKMAGKNNKFIKDAFSQGIVLRDDFGIANISINSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3J7</accession>
    <name>A0A1V0N3J7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887926.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3J7"/>
    <dbReference type="STRING" id="74969.FAD_0818"/>
    <dbReference type="GeneID" id="24787228"/>
    <dbReference type="GeneID" id="31676320"/>
    <dbReference type="KEGG" id="fai:FAD_0818"/>
    <dbReference type="OrthoDB" id="29123at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="entry name" value="Putative sugar-binding, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142764">
        <property type="entry name" value="YgbK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="174" mass="19369" checksum="00EDFFD86A61922F" modified="2017-06-07" version="1">MLTIIISDDLSGAAGMASLIAPHIPVVPYNRLHDHGKPDSEIVSIDLETRNLEDPRPRLDMVKHTFPGARILARIDSLFRGSTLDFVAFIAEYGNILLTDTIPEYGMYTFNGSSINRNGSINIIKMLPDNLSPYVKIADSQSYGDIEKLAKKCVDENLMPVDPGVLIKYYLEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3L3</accession>
    <name>A0A1V0N3L3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Diaminopimelate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141962.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3L3"/>
    <dbReference type="STRING" id="74969.FAD_0782"/>
    <dbReference type="GeneID" id="31676284"/>
    <dbReference type="KEGG" id="fai:FAD_0782"/>
    <dbReference type="OrthoDB" id="24854at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010589">
        <property type="entry name" value="PRK13983.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF32">
        <property type="entry name" value="ARGE_DAPE-RELATED DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="189"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="397" mass="44399" checksum="43D50CA9D3F96A48" modified="2017-06-07" version="1">MELVKASDREFIVAVAQRLLAITSISPQSGGEGELKKSLELKKILNELGYDSYNEYNTTDNTGTIRPNIVLKLGSSSKTLWVICHMDTVPVGDISLWKHEPFKATIEGDKIYGRGSEDNGQSIFTMLLLLKHIKREQMKMNLNVAFVSDEETGNDYGIKYLISKGIFAKDDLIIVPDAGTEGGFIIETAEKSTMQLKFEINGIQGHASMPENSLNAFRVACKFIDLMDFNLHDQFGKTNKLFVPPYSTFEPTKHEQNIENINTIPGRDVFYWDFRILPQYPADEILKSIDGLIEKFSKTSGAKIKYTVIDRVDAPDPTPDGAEIVVLLKKAIKSVIGKDAFTVGIGGETFASFLRGKGFSVAVWSTTVIESAHMPDEYCLIPHILQDIEVYKYILYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3N0</accession>
    <name>A0A1V0N3N0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Preprotein translocase subunit SecG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Protein transport protein Sec61 subunit beta homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">secG</name>
        <name evidence="14" type="ORF">FAD_0784</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887883.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3N0"/>
    <dbReference type="STRING" id="74969.FAD_0784"/>
    <dbReference type="GeneID" id="84220404"/>
    <dbReference type="KEGG" id="fai:FAD_0784"/>
    <dbReference type="OrthoDB" id="43651at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00751">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023531">
        <property type="entry name" value="Preprot_translocase_SecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002318">
        <property type="entry name" value="PRK01253.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="55" mass="6152" checksum="CFD374357EC7AD55" modified="2017-06-07" version="1">MAKDNQNENFQSGAGLIRYFNEEEIKGPAIDPKLIIYIGIAMGVIVELAKVFWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3N6</accession>
    <name>A0A1V0N3N6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11 12">Threonine synthase</fullName>
            <ecNumber evidence="4 11 12">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FAD_0783</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4 11 12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141975.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3N6"/>
    <dbReference type="STRING" id="74969.FAD_0783"/>
    <dbReference type="GeneID" id="31676285"/>
    <dbReference type="KEGG" id="fai:FAD_0783"/>
    <dbReference type="OrthoDB" id="6371at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01563">
        <property type="entry name" value="Thr-synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="16">
        <location>
            <begin position="65"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)" evidence="15">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="NCBIfam" id="TIGR00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ARD84686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="387" mass="42295" checksum="5D8BAF7118CA4803" modified="2017-06-07" version="1">MTHSVLKCPSCNAEYTIDSNIYICGKCGNILDVFHNNMEYSLTNMKGVWKYKNLIHPEIPEKAIITRGEGNTMLYRNARISNYSGVDKIFLKHEGENPTGSFKDRGMTVAVSEAVRLNFNKTLCASTGNTSAAAASYSAFGGIESYVMIPGKNVSANKLFQAIAYGANIVDIEGDFDTAMENVKKAIAKRNDFYILNSLNPWRIEGQKTIIYEIMEKIKPDFITFPAGNLGNTSAFGKALMDLRALGVIDYVPKLVAIQASGASPFYDYINGKEDTIHPVKAETIASAIKIGNPVNYKKAKRAIEFTKGIVEKVTDEQIMEAKREIDRSGIGCEPASAASVAGVKKLKESGIISRGDTVASILTGNILKDVSLVSEHKTLSIQDIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3P1</accession>
    <name>A0A1V0N3P1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141987.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3P1"/>
    <dbReference type="STRING" id="74969.FAD_0794"/>
    <dbReference type="GeneID" id="31676297"/>
    <dbReference type="KEGG" id="fai:FAD_0794"/>
    <dbReference type="OrthoDB" id="45637at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025103">
        <property type="entry name" value="DUF4011"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049468">
        <property type="entry name" value="Restrct_endonuc-II-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF530">
        <property type="entry name" value="SUPERFAMILY I DNA HELICASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13195">
        <property type="entry name" value="DUF4011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18741">
        <property type="entry name" value="MTES_1575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="1">
        <location>
            <begin position="257"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="1">
        <location>
            <begin position="863"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="2">
        <location>
            <begin position="938"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="Restriction endonuclease type II-like" evidence="3">
        <location>
            <begin position="1164"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1274" mass="145881" checksum="00F6575065E9826F" modified="2017-06-07" version="1">MDIDIDESIKKWEKDVIDTSKNNRLLYFNPESFLKITTPSMLFLFDDLVNKDKKMKIHLSGAEENRKKDELIFSKNEDISKSLGNLFYQANASLKEHGSNVLYISFGVLKWSDENGKEVETQLFFVPVTLNRKMYNNYSIESMEGDIFFNPVLREKLEQFGIKFDFNFDDNLNLSEAIKTFRLTVKDSKWTVGRNSYLGIVSFTNNTIYNDIKGNHDAIKKNDLTRALAGDFEVIKKLNDKMPAEIDYNINTVMDADSSQLMAIYAARSGSSFILNGPPGTGKSQTIANIIADSMKNNKSVLFVSEKNAAIEVVKRRLEEVGLGDFILNFHGNTPKSEIIKSLHRSVENDTHAQRTLVPTDRYSGTLNSYVRAIHEKRGKLGRSIYDACQIELKNKGNLDIKIDRRLLDLTGEELDSLEFQISEFNDYLDIIENYGKIPENFRLDRYREDPEHYYRGLELIQNALDRIEEIAPAILTTTGVDIQSMEDINMLYRFVNVLNAGITLDEAYTNPDFIKETAALLDSGEKIRSELDYMMGIFLKKRKKQFLDMNLNSIRKDMEETYSSRWKRHSGEYKKLLNEIMENTEDKSRKQYEEILEDITFALKIKAKQDELSVVEKEISSRDIGASNVSEKIRYARKLISIFPENALKDGLRELISHPVDPEYIEDIKSIHSSLIDGINYLSDIFPSYSGLNTATMEQMRQAIDAASSFDIDRYVKFRELYEGVKTSGIDIAPLLNTRVHMNSILHSFRYIFNHEFATYYVRNDPELKNFRASSHERLIGMFIDFDRKRIEINSANLVVELSARRKEALSRYPGSAMVIKTENAKKRLQKPLKVLFSELKDILPGLKPCIMMSPDNVAAYLENDASFDLLIFDEASQLTPPDAVGSLIRAKQAIISGDTQQLPPTTFFEYVNPSKYEDDYVVLDNILDQFDAIGLSKIWLKWHYRSVDDRLIAFSNRYFYDNLLETFPSSYRKSKESGIQFVRVEGVYTRGKSKTNKAEANEVVRVIKEELSNTDSIGVVTLSESQRVAVEDTLNSYSRHDPVLAELLNNDTIFIKNLENVQGDEKDVIILSTGYGRDENGKITMNFGPINTTGGEKRLNVAITRARKKFIVVSSMDPEDIRVPANSGKGPDLLKQYMIYAKNEGNNEHLEEFKNNDAIINDIALKLEQEGFKVAKNVGYSRNNIPLAIIDPDDQDHYILGIETDGKIYNSMKTASERERIRKKILTDRGWNLYRIWSIDYMKNPEKVLHDLINSVGRLGNGENAKSAGREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3P5</accession>
    <name>A0A1V0N3P5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142129.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3P5"/>
    <dbReference type="GeneID" id="31676393"/>
    <dbReference type="KEGG" id="fai:FAD_0889"/>
    <dbReference type="OrthoDB" id="146522at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20770" checksum="E0D62C9C108C377C" modified="2017-06-07" version="1">MENKEGVDTTLARDSFEELRHIFSWSTAYETFRPGGIILIGGWAVHSFNPWKYSLDIDFIATGCFKYHLKEHLYSKRNYSKGKDSAGNTLYLKSLDSGDIYLDFLPNKDQFHGTDKLLNLSEIKYETITKNISYTFESEFQVIVPEISMLLLLKLKVAWDRLYDLSYDTTPNREHLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3P7</accession>
    <name>A0A1V0N3P7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142014.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3P7"/>
    <dbReference type="STRING" id="74969.FAD_0819"/>
    <dbReference type="GeneID" id="31676321"/>
    <dbReference type="KEGG" id="fai:FAD_0819"/>
    <dbReference type="OrthoDB" id="56357at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043958">
        <property type="entry name" value="Ta1207"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19020">
        <property type="entry name" value="Ta1207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="316" mass="36893" checksum="8F40D3B63028DB6F" modified="2017-06-07" version="1">MDRKDVNLKMDMKMKLVISGNADIFRWSKLHNITMSIFIKEDSQNSGDYYFEAFIAKDQEIAGFKELIDAYGAIESEHFFLVVRPLVNQKILNFIKELWTVPSISFSETKVENGKLILRIIFHSNYKKDLSLILNRYLVIPYFIDDIILTKNEGFTYLLEKKNKRVPLSIIQYSLPLSIHDGDDISRILEENNGIAEVVESPYDRDNFKLHLFLENPVEENDKIRVISREDKIYEAYSTNKLLSTIRNKANERGIFRNQLFIKIKDGRIYSSSSVNTYRAMEYLKLTFASSMGLYGKNFIRLENCTDFDPSLHDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3R7</accession>
    <name>A0A1V0N3R7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142165.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3R7"/>
    <dbReference type="STRING" id="74969.FAD_0908"/>
    <dbReference type="GeneID" id="31676411"/>
    <dbReference type="KEGG" id="fai:FAD_0908"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="241"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41763" checksum="827D3267DF7A91E4" modified="2017-06-07" version="1">MRILEVSFLNPYQSNSGGVESYIVKITNFLRENNKITIICSSTNKTMKHDNIIELYTGKFLRKSIYNIRLYFYVKKHRNEFDLIHINGDNGFLIPLINNMKTVMTLHGSMLENTMVNIKNFKFRSIISYITGVFLGYMEIFACKRANKIIAVSKHIKTYFSEYTGRNSINYIPTCINKMDTINISETDKLRIAEMKSEYKTVCLWTGIDPERKGLGIAKNAVSNFDDVILFTAGYKDENRAKNVINLGYVDKDLLLYLYQISDIFIFPSMYEGFSIALLEAMSYGAIPLSFKIPATEELITDSVDGFLLHDASKFEDKIKYLVQNTDKMEIMKKNVSRRAEDFYCSKILLEIESTFKELLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3U9</accession>
    <name>A0A1V0N3U9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142218.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3U9"/>
    <dbReference type="STRING" id="74969.FAD_0946"/>
    <dbReference type="GeneID" id="31676450"/>
    <dbReference type="KEGG" id="fai:FAD_0946"/>
    <dbReference type="OrthoDB" id="382672at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="245" mass="28442" checksum="C38A938F0F025602" modified="2017-06-07" version="1">MQQDERISSLNREINLITFIGYREYLVLNFIRDNIKVNPSIIYIFSSKLPVLPSEQSNAQNEIILKKLKEYVKMNGKDVQIKENRTDNLWDIKYYYRTLKRLPAESNYIINISSGPGVYSAAAMLWALESDNQISYSVESWHNKTLQSAIFRNLNMQSFSFFNFKTDNMDRLIITALELGHNTTIDIKEYLSKQKGYKTTLRNIQVHIRELCNSGVLITDGNKPSTISFSNEFSKLGYSSSDFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3V0</accession>
    <name>A0A1V0N3V0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3V0"/>
    <dbReference type="STRING" id="74969.FAD_0871"/>
    <dbReference type="KEGG" id="fai:FAD_0871"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="81"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="248" mass="28537" checksum="7CA6AE9C627D880E" modified="2017-06-07" version="1">MVITIHDIIPFHRNVENDNMMENIKQHFIKKYIREYMKYDNIVTLTSHIKNQIISEFNVNEKNITVIPPYIPDSFFPLSGKEQLRKELGLPLDKRLILSISSDQPRKNLQMVKRVMANLDDSFKLVRVGTPIGDSITFNNVDIVKLNKIYNASDMLFLPTKEEGFGYPVVEAFSTGLPVLSSNIDVLKEVTNGAALLINPEELKENVEGVYSIMDNHEYYTKKGYERAKYYSSSAVKKQLVSYYNSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3W8</accession>
    <name>A0A1V0N3W8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN-domain RNase, VapC-type toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795574.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3W8"/>
    <dbReference type="STRING" id="74969.FAD_0968"/>
    <dbReference type="GeneID" id="31676467"/>
    <dbReference type="KEGG" id="fai:FAD_0968"/>
    <dbReference type="OrthoDB" id="275611at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09874">
        <property type="entry name" value="PIN_MT3492-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="144" mass="16543" checksum="1E95FD3068A40435" modified="2017-06-07" version="1">MNVYLDTSAYVKRYINEANSDSIDALFNDAYNNKIKIITSILTIGEISIVFDKLWRKQIIEEPIEMFNRFYDEVRNLIKLNAIDLININSHIMIRSSKICMDLHKPLADVIHIVSSMNISSIFITADKEQNSIASSLGVKTRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N417</accession>
    <name>A0A1V0N417_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CRISPR-associated protein Cas6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cas6</name>
        <name evidence="5" type="ORF">FAD_0945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N417"/>
    <dbReference type="STRING" id="74969.FAD_0945"/>
    <dbReference type="KEGG" id="fai:FAD_0945"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21140">
        <property type="entry name" value="Cas6_I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049435">
        <property type="entry name" value="Cas_Cas6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS6 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984:SF1">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS6 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21350">
        <property type="entry name" value="Cas6_I-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01881">
        <property type="entry name" value="Cas_Cas6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRISPR associated protein Cas6 C-terminal" evidence="4">
        <location>
            <begin position="131"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="245" mass="28098" checksum="2B50F60F164F8475" modified="2017-06-07" version="1">MDINFIMKSTKLYIKRVDGKIIPFEYNYFIGISIYKKLLNFQEDIIPLHRSSQIGIYTFSNIISPFIPRSELFADNGLNIDKGYIIFRTLNEKLIDYLRLGILQDNKIRIKDTVFEVSRIEDIKPYNGDADELKFKSLSPILVRDYIRKKIYVNDEQNVAPNLKLVIENQLSKFFGINSSSVNFSDLTPRKKSIRISSNGKKESISTGFNLSGTITAQPDILKLLYYKGLGSKTSLGLGCWEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N457</accession>
    <name>A0A1V0N457_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase class-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142405.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N457"/>
    <dbReference type="STRING" id="74969.FAD_1042"/>
    <dbReference type="GeneID" id="31676541"/>
    <dbReference type="KEGG" id="fai:FAD_1042"/>
    <dbReference type="OrthoDB" id="57405at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00981">
        <property type="entry name" value="arch_gltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01907">
        <property type="entry name" value="GlxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035710">
        <property type="entry name" value="Archaeal_gltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012075">
        <property type="entry name" value="Glu_synth_lsu_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39673">
        <property type="entry name" value="TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE, SUBUNIT C (FWDC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39673:SF5">
        <property type="entry name" value="TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036632">
        <property type="entry name" value="GOGAT_lg_1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="631" mass="70493" checksum="F7604BC34D7B0505" modified="2017-06-07" version="1">MNYIPSSCGLFGIMRKNGREKIPGTIPVKCLNSIRYRGSDKGSGYASFNVNHNNNYSINVFYEEDEHKLRSLLEQNGFGINKMEVRNGNNIKSYCYDVSIGDMSSIDNVNDVLWKEGTGRIYSSGTSLDIFKGIGYPDDVGKEYSIESKEADMWLAHTRQPTNSPGSLPYWSHPFSSFNIAIVHNGDISSFGANREFLKSKGVNSFVGTDSEVIAYIFRELLKQYDLITTVKIMAGKIEDSSMKYKNRGAVLDGPYTLVIGYDDGNDLYMICIADRTKLRPAILGEDDGNFFIASEESQIRLISPNARIWTLEPDSYFIASFNRGIISPGRKGIENRNKINIPDSFQIDARAIEYNRLNQAILKGDQAITINNVAGHRYIGINFPDSEKDITIYGTPGNCFMNLNENNSSTIYGNVADDCCDSMGGGMVKIYGDAGDILCQALNGGKVYVLGNAGNRACIQMREYVDKSTVVVINGKFDDYLGEYMSGGTLLVLSNSDRNFGRYIGSGMIGGTIFIRGKVNSRNIGIQPPETAVNGMLNALRKSELITDKEYHKLKGMSFIDMIKFLPSDSRKFVRKFYSGHELPEYEYRYLNSQEKIKLNSIVNEFDTEMGTHSTEFLGDKFTIIMPGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N482</accession>
    <name>A0A1V0N482_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1,3-propanediol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142445.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N482"/>
    <dbReference type="STRING" id="74969.FAD_1071"/>
    <dbReference type="GeneID" id="84217671"/>
    <dbReference type="KEGG" id="fai:FAD_1071"/>
    <dbReference type="OrthoDB" id="57329at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08551">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF102">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="4">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="201"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="414" mass="45335" checksum="D339F91546BFF72F" modified="2017-06-07" version="1">MDDFENRYTYNNELKFDQVKRILFGVGQSMLVGEQLKEIGKKNTIIVTDPNVYKFGLLDNIEKSLSKSQIKYEVYDKISNEPTMDNIVNAVEFARSNGKFDSVVAVGGGSVLDTSKMVASMVTNKGEPAEYLTPVEDKFKNPGLPKILIPTTGGTGSEVSNMSVVINRESMYKTWAASSNLLADTAIVDPVLNVSAPPRTTAASGMDALAHNVEGLISKEANPISDGIATKAASLIFRNLRTAYNDPSNIEARSAMSMSAMLGGMVITFPWVAGPSVLGHCLGEAFGPKYGAIHGVAVGMALPYILDFNISAAYNKISSLARIFNIRYKGESARVVASKIPPAIIQLLEDLEMPTTLKDINFPASDIEKFGDYIFSSRQKLYDLPRFNPRRLTKENSIRLIQNMYDGTLENQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N487</accession>
    <name>A0A1V0N487_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142371.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N487"/>
    <dbReference type="GeneID" id="31676524"/>
    <dbReference type="KEGG" id="fai:FAD_1025"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="156" mass="17867" checksum="DDCF6F6BFADA7F07" modified="2017-06-07" version="1">MFNYRKVIATLITFILVFIIIMSGYIYYHNFDENNNKIYNDSISKINVGQIGIDYNYTKIIFPNTVNSNSNFNIIILFNSNISIKYIYTQTSGFCVSEWSFHYGSYTENGTTQGEFIGSVAENIGILNITIKAPDHYYNGYISLHLVGNVPETVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4B0</accession>
    <name>A0A1V0N4B0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142417.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4B0"/>
    <dbReference type="GeneID" id="31676554"/>
    <dbReference type="KEGG" id="fai:FAD_1055"/>
    <dbReference type="OrthoDB" id="57311at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24877" checksum="E47DD01C6FCAF287" modified="2017-06-07" version="1">MYILAVISTIIILILSLGLSILISSNYIRKKQLNLLAWTSGLWVFSISVALEVVFSTNYETPLLMKSYLILVAVLVELLALGSVLLLKKHNITIYYGIYMIISTVFVIVSAVISHVGDIVTHGVVYGVLPILISISSITVTFPAAILLIYISLTSYIKTKNPKLLSIVVGVIIVSVAGTLYIVEFPAFLYYAEFFGILLLWIGFVDFKVLKNLFKANNNIAPKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4C0</accession>
    <name>A0A1V0N4C0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142433.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4C0"/>
    <dbReference type="GeneID" id="84217664"/>
    <dbReference type="KEGG" id="fai:FAD_1065"/>
    <dbReference type="OrthoDB" id="27380at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="672" mass="76381" checksum="005112D531B92E68" modified="2017-06-07" version="1">MKFEWMPFRIKNIFKDGKTVNYHSIIIVLSIIFAIFFSFYSILKAYTLNAYAWDLGLYSQAFYSSLHGQLFYSNLLGESYLAEHFSPFMFALLGVFYIYPNPYILLIIQAVFLSFATIPLYYISLHIFSRIKEKYPENIKNPALYSFIIASAFLLSPLTESPIYFDFHLMIFLPFFYFMAIYFYIKNRMAWNIVFLALIVSLHASFVFIVVMTLIMEMMISRYYFKESGEQTKKMAYLFITSLIVLLIYYTAAGYLKGDIAHSQSILLFASGATGSASRSITGLVLTFFLHPYRFMTYIIANYQIKLLFLVLAFLAVDFAFYRFPIGLIPAIPYLVYAMTSSYIPYYFIGYQYSMMFIPMIFVAAVFGISKMMEFKPTPSIKTKRAARNLKNTMLVIAVFAIAAFIVVSPISPVSVEPSGIHNIVNDSAGYSAERNHFVYSLENNISMNSSLVTGNNIYPLFYKDLNATAFPYNNISSTSVHFKYLIADLNDSQTYTRNRHNISLANLALEYMNSGSYGILAEGYGVIALELHYTGKPLIFNPLNVSYSSKEFDHTNGKVYGPIPDKNMSSFQKLENLGKNVYSGNTTYILPGNYSISVYLNSSYKIPASGINITILDNGNVTLYRINSSSYRLNGETLTFNLNSTEMHTGVTYVFTGIPSINGMSIIQDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4C5</accession>
    <name>A0A1V0N4C5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886208.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4C5"/>
    <dbReference type="STRING" id="74969.FAD_1105"/>
    <dbReference type="GeneID" id="16024334"/>
    <dbReference type="KEGG" id="fai:FAD_1105"/>
    <dbReference type="OrthoDB" id="41102at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="140" mass="16607" checksum="2065E11C07294B36" modified="2017-06-07" version="1">MNNYKKFEIDFINAWNSHNIFELLKYYDDDMLYIHPGEEPKIIRKKGDFEVYLKKFFETFPDYTFTLINVAWNNNVGFGEWLGKATFNGLRYNLKISNKPFEIYGVDVLVLNKSHTCIKEEHVYFDVLSVLKAVGINIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4D4</accession>
    <name>A0A1V0N4D4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxB</name>
        <name evidence="4" type="ORF">FAD_1124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142495.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4D4"/>
    <dbReference type="STRING" id="74969.FAD_1124"/>
    <dbReference type="GeneID" id="31676621"/>
    <dbReference type="KEGG" id="fai:FAD_1124"/>
    <dbReference type="OrthoDB" id="27340at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="318" mass="34276" checksum="F2228D117D5B6028" modified="2017-06-07" version="1">MDSYDTIIVGGASSGLSAAIYAARQGMKTLVITKDIGGQALLTTDIQNYPGFDMIGGFELANKFKEQAEHYGTEFVYDEVLKISKEGDKFSLKTAGKEYSSMSLILAFGKTPRDLDVKGESRLKGHGISYCAICDGPLFKGKEVAVVGNGSHALEALVYLSSVAGKVYYITNAKKLSGEDELLQTVNSIENKEIYFDSVPASINGSESVESITFQNKSSGNNQTVKLSGVFAEKGYIAKSEFVRNLVDLNENNEVVVDKYCKTSTDGVFACGDVTDTPYKQAVISAGQGAIAALSAYNYVQKRKGKVAAKSDWKLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4D8</accession>
    <name>A0A1V0N4D8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142472.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4D8"/>
    <dbReference type="STRING" id="74969.FAD_1085"/>
    <dbReference type="GeneID" id="31676583"/>
    <dbReference type="KEGG" id="fai:FAD_1085"/>
    <dbReference type="OrthoDB" id="7442at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="234" mass="25359" checksum="AF864E26D7E4AE75" modified="2017-06-07" version="1">MKSNIVIAGIGKGMGSSLAYYLKDAGYNVFLISRGSNVKEVAGKAGCEFYNADLNSYPQCVEAIKAADRTMGGIDAVVNVAGNYYSNQSIEETEPEMFMDAILNNARTFYNIARAALPLLKRQKHGSIIGFSASENVYYNSNPGYASGKGAVYFMVKSLARELIKYNIKVNGVAPGFIGKNDDEIKSNIELGIARRYPPDDINRTVEFLINSEMVTGEIIPVAGGHDINLNSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4F7</accession>
    <name>A0A1V0N4F7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4382 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142531.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4F7"/>
    <dbReference type="STRING" id="74969.FAD_1146"/>
    <dbReference type="GeneID" id="84217743"/>
    <dbReference type="KEGG" id="fai:FAD_1146"/>
    <dbReference type="OrthoDB" id="56852at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025491">
        <property type="entry name" value="DUF4382"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14321">
        <property type="entry name" value="DUF4382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4382" evidence="2">
        <location>
            <begin position="32"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="188" mass="20056" checksum="A7B6CB1853EF1267" modified="2017-06-07" version="1">MKSKKLMSVIVAIIIIAVIAGGSYYAYHYETTGTMKVSAADTPTNLIGVMDVNVTFSAIALHSDKVSSNSTGWTNYSLHDKTVNIMNLNASNAAFLSNLSVHAGSYNLIKIYIKNVTIYVNTSVTSLFGANATVSLHLAHDFALVVLVHPVTVSAHSTTSIVTDFNLSNNIHVSSHTFSMSATVDVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4J5</accession>
    <name>A0A1V0N4J5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3834 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1151</name>
        <name evidence="2" type="ORF">HLB00_02755</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000087">
        <property type="protein sequence ID" value="NOL59754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886255.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4J5"/>
    <dbReference type="STRING" id="74969.FAD_1151"/>
    <dbReference type="GeneID" id="16024380"/>
    <dbReference type="KEGG" id="fai:FAD_1151"/>
    <dbReference type="OrthoDB" id="56755at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024533">
        <property type="entry name" value="DUF3834"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12916">
        <property type="entry name" value="DUF3834"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="225" mass="24836" checksum="73483DB16D99597D" modified="2017-06-07" version="1">MKVIAAPGPVCYPLVAAMMERKDIDIEFKKSSEIGNDKPDVVLDSTVSLVKSGLPIDYVTINGLSRVAPKLGYKVGMTRKGGAADILFRAYVGESKKDVEIEYFENMSDLMGALNSNKVDTVVVPAIDNSGVSIEEYMKKINVNIPGSCGATVYNNEKEFVDAYNLGIKLLKEKPEEAAKFVVEHLPMQFPVEFVANTMKNSNLNVHKPENYDVFVNLVKKYSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4J8</accession>
    <name>A0A1V0N4J8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="4 6">N5-CAIR synthase</shortName>
            <ecNumber evidence="4 6">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">purK</name>
        <name evidence="8" type="ORF">FAD_1149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + hydrogencarbonate + ATP = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="4 6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142537.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4J8"/>
    <dbReference type="STRING" id="74969.FAD_1149"/>
    <dbReference type="GeneID" id="31676647"/>
    <dbReference type="KEGG" id="fai:FAD_1149"/>
    <dbReference type="OrthoDB" id="9299at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="97"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="163"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="359" mass="41320" checksum="4C33B015C3CCE5D3" modified="2017-06-07" version="1">MKVGIIGSGQLGYMMINTMRRYPIEFYVIDDNKGPSAFIADKFFDVSQYKEFVDSCDYVTYEFEHIDKNILEYADSKGKLRPSIKAVELKQDRSLEKKYLKDHGFPIADYEYAETYRDAFNKAKNFGKAVIKSCKGGYDGKNQYFIDNSSRFEEHPDIPYVVEKFIDYEYEASIIAVRDANGKFYHFEPSFNYNQNGILIYNISPIGNTIEMIDIAKKLMDSLEYIGVMGIEYYVVDGKVIINEYAPRVHNTGHHTLTGSSISQFEEHILAVAGMNIVRPDLFVPSGIVNIIGTDIKEKIGPVLNLGNTNIYWYHKNEVRGKRKMGHVNVYGESYNAVEQKIREIIEILYGDRLEDFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4K5</accession>
    <name>A0A1V0N4K5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="6">DHBP synthase</shortName>
            <ecNumber evidence="6">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ribB</name>
        <name evidence="7" type="ORF">FAD_1196</name>
        <name evidence="8" type="ORF">HLB00_09815</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000437">
        <property type="protein sequence ID" value="NOL61113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142577.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4K5"/>
    <dbReference type="STRING" id="74969.FAD_1196"/>
    <dbReference type="GeneID" id="84217791"/>
    <dbReference type="KEGG" id="fai:FAD_1196"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF46">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL61113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="230" mass="26418" checksum="A5498479C7A49789" modified="2017-06-07" version="1">MIDEAIKALKNKKMILIHDFNDRENETDMVIASEFVTPEIIRTMRKDGGGLICTTIREKDAKKFNLPYLDDLFYRSLDMDKSVLNSSDMGYDTKDAFSLTVNSRDTYTGIPDNDRYKTVKHFSEFINSLGNNANENEKNFGKIFRVPGHIHLLIARNNYFKERKGHTELSTYIVEKAGLIPSATIVETLSDSFNSMTLEESKKYADEHNIVLINGKEIIDDFNKTDRILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4N1</accession>
    <name>A0A1V0N4N1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4N1"/>
    <dbReference type="STRING" id="74969.FAD_1174"/>
    <dbReference type="KEGG" id="fai:FAD_1174"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="48"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="294" mass="33095" checksum="6009CDEE08641D82" modified="2017-06-07" version="1">MIFEEPQVVTLKNSNFYILFKHKYNMFESSRSYYLKIDHLIIPMFKGTNSSKVLKMSYDMAKANNSEITAITIREKNDPIDISGRLGVVTTAYNEGKKAGIKVIPKIQTFDNAREGLVMETSGHYYDLLILSTRKRSMLSSSIFGNIGDYVLKNSSIPVAILSSGERGYPYSNIMLPLSESINTRAAVFFALQLAKLNRSNVTILDLRKYDKNPVHGFKALMENPGILSESKIEIRIVRSGGFTGIKEEVGNYIKSDNPDCIVVGTSRSHNIRMTSDIKFIIKEPEIDTILVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4P9</accession>
    <name>A0A1V0N4P9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1241</name>
        <name evidence="4" type="ORF">HLB00_06090</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000206">
        <property type="protein sequence ID" value="NOL60402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142656.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4P9"/>
    <dbReference type="GeneID" id="84217837"/>
    <dbReference type="KEGG" id="fai:FAD_1241"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="172" mass="19332" checksum="7E5B2D0C94665297" modified="2017-06-07" version="1">MTEENSAEPNPEENYSPDTENSGHKETGTQNREPVKTTPVKPDKNVKLYIEIGIAIVGIILIIIASVQIKGIAHVKWNEFSEIALPLSIIFIVLPSLLYFKKLRSLKPALTLVIIAVIGIILLYYLLAPYKMFSVRFGLLGDVLVEYLIGIFLVIFMISHLTKVHLMKNKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4R7</accession>
    <name>A0A1V0N4R7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0173 metal-dependent hydrolase FAD_1264</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0173 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142704.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4R7"/>
    <dbReference type="STRING" id="74969.FAD_1264"/>
    <dbReference type="GeneID" id="31676762"/>
    <dbReference type="KEGG" id="fai:FAD_1264"/>
    <dbReference type="OrthoDB" id="28313at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00457">
        <property type="entry name" value="UPF0173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022877">
        <property type="entry name" value="UPF0173"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001911">
        <property type="entry name" value="PRK00685.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF3">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="224" mass="24267" checksum="34C2115046BCC0D9" modified="2017-06-07" version="1">MATEIIWHGHAGFSIKNAVNILVDPFFSGNPLSSEDVNSIKADLILVTHGHFDHAGDAVTIAKKNGCPIVCSFELSEIIKKENVETIDINPGGTIEYNGVKATAVPAIHSSSYNGAYAGEAMGFIIDNGDLKIYHAGDTTFFKDMELIGEIYHPDVAMLPIGGHYTMDVDGAIEALKLLKVKNAIPMHYNTFPPIKADASEFQKKAERSGIKAIVPEIARPFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4S3</accession>
    <name>A0A1V0N4S3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1272</name>
        <name evidence="10" type="ORF">HLB00_03225</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000103">
        <property type="protein sequence ID" value="NOL59845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142733.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4S3"/>
    <dbReference type="STRING" id="74969.FAD_1272"/>
    <dbReference type="GeneID" id="84217867"/>
    <dbReference type="KEGG" id="fai:FAD_1272"/>
    <dbReference type="OrthoDB" id="29061at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="16"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="387" mass="42257" checksum="BCFB151AC296DA3E" modified="2017-06-07" version="1">MAFNITGGNNRHYSGILGSSIMSFSMNSTLRFFIPVLIPLLVSSLNISVYLGSLLITAYWLGYTVFQIPAGMISDRVGVSKVAKISFILMVLSFSLFYFFIDSYTGIFIIQILLGSFSATVYLSDTSVIQKWLPQSSRATFVGIYQTGFFIGASLGEYLILRTLSIGFHFAFIVILSILIIATILNIVFLREPEHNKLAKHGKIDRKIIYVAMIRFSAGFLYIGFITLFTTFIVFDHIVPYSSAYLYAWIPAAGGIITSPLGGMISRRMKHGKSIVSVLPVVALAVTIIYINYAPVSAIFIISFLSGMFYGLYAGPSMGMASDFSGSDANLASSSSILNFSSQVGGTVSPLLMGFMFSIYGNFALAFTAVAAISIITLIIPFIKLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4S6</accession>
    <name>A0A1V0N4S6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4S6"/>
    <dbReference type="STRING" id="74969.FAD_1270"/>
    <dbReference type="KEGG" id="fai:FAD_1270"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="162"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="273"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="550" mass="61623" checksum="19F009933DC99811" modified="2017-06-07" version="1">MNMDDTYSFLSSIYGKNHYDIDKPFQEILEFYMGKHLNLSPLGAYAGKDLYETTDYIDKVSQPLQKMWSIDGKRIDSILISPMEKHVLDKLIREYGISRPYFHGKSIMEHYAMGYLVADPGIYCILTLTHQTAYAIHKYAPDFQKDYVPGLIGDTKDTLLGATWFTEIQGGSDLGANKTRAESGNGLWYLTGDKYFASNAGLADVALTSAFHGDNHGAKGLSLFLIPRKNNDGELNYRLRRLKEKSATKSVPSGEVELDSSEAYMIGDAGKAIYYITEDLMVSRLDNAAAACGIARKAYLEAYYYTGKRKTFGKLLIEHPGIVKDLLDMEVLLEGSIALTFKSIELFNNSINSKPPYDDEYNYTRLMTHIVKNITADSSARVTQMATELHGGIGFLSEFPVERWHREALITPIWEGASNIQALDMLEAIMRKKAHIKLLSDFKNILSEIREETATAESCYNSLKNSIDNLLSMGVEEAQFHAKYSMEVMGHSMAAILLIHIGNKTGNNDFVKAGSLYARRFVKKEDYESNAIGQAHGIIHIDGAERSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4U4</accession>
    <name>A0A1V0N4U4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Type-4 uracil-DNA glycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">udgA</name>
        <name evidence="16" type="ORF">FAD_1259</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142698.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4U4"/>
    <dbReference type="STRING" id="74969.FAD_1259"/>
    <dbReference type="GeneID" id="31676757"/>
    <dbReference type="KEGG" id="fai:FAD_1259"/>
    <dbReference type="OrthoDB" id="25379at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="NUDIX_Ap4A_Nudt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10030">
        <property type="entry name" value="UDG-F4_TTUDGA_SPO1dp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051536">
        <property type="entry name" value="UDG_Type-4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33693:SF1">
        <property type="entry name" value="TYPE-4 URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33693">
        <property type="entry name" value="TYPE-5 URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="15">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD85127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="321" mass="36782" checksum="E1A23254DA628695" modified="2017-06-07" version="1">MREEFSYGTVVYSKFNNEYKYLLLKREEGWLDFPKGHIEKGEDGVKAALRETCEESGVCLQPGNLVPGFYYNIDYFFTYKGTKILKHVGMYLSEISPDTTVKVSNEHRGYVWLNYQEAMEALRFGNQKGLLEYTSTYIEKLDRMRVLNKEYGEIYRGRKWDLSTVFVPGEGNLNAAIFIVGQAPGRNEDIMKKPFVGRSGKLLESLITDELHTDRESLYITSVVQFFPPENRAPSDEEIALCLPYLMKQIEIVNPAIIVLLGAVAARTLAQVKSIMKEHGKLFMDKYYVTLHPAAALRNPANIEIMRSDFRALEKIVNGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4W0</accession>
    <name>A0A1V0N4W0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1268</name>
        <name evidence="2" type="ORF">HLB00_03205</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000102">
        <property type="protein sequence ID" value="NOL59841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142725.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4W0"/>
    <dbReference type="STRING" id="74969.FAD_1268"/>
    <dbReference type="GeneID" id="84217863"/>
    <dbReference type="KEGG" id="fai:FAD_1268"/>
    <dbReference type="OrthoDB" id="35747at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="entry name" value="Protein of unknown function UPF0759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348:SF4">
        <property type="entry name" value="DUF72 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YECE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="TM1631-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="261" mass="30585" checksum="F501714EDF486AA6" modified="2017-06-07" version="1">MIYRTGCSGWSYDFWKGKIYDYSESPSNYLRDYARIFDTVEIDSTFYAAQNSETVEKWASSVPENFLFSPKMPRKITHESRLERCEDDLAYFMKNISLLNNRLGTVLIQLPPDFPINTGVLENFIELLPNNIKYAIEFRHPSWFIDEVYGILRKSGITMVWSVLDYIKTPEIKTTENLYVRFLGNKSLEKKDLGEIRINRHREIEQWIGKIKKQDSGQGTVFIYANNHYEGLSPDTIKFIRQELGLPASGNMLMDRQKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Z3</accession>
    <name>A0A1V0N4Z3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA topoisomerase 1</fullName>
            <ecNumber evidence="12">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">topA</name>
        <name evidence="15" type="ORF">FAD_1330</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Z3"/>
    <dbReference type="STRING" id="74969.FAD_1330"/>
    <dbReference type="KEGG" id="fai:FAD_1330"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.65.10">
        <property type="entry name" value="Bacterial Topoisomerase I, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005555">
        <property type="entry name" value="PRK07220.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF26">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="Zn_ribbon_Top1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 12" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="14">
        <location>
            <begin position="144"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="12">
        <location>
            <begin position="182"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="748" mass="85176" checksum="EDACF44FE35F5841" modified="2017-06-07" version="1">MDAGRRISYILSDKTSKQKKTKNISYIEFERNNEQNIMVSLSGHILGADFPEEFKDWVKSDLDKLIDSNIIYKVTNQRAYSALKSFSGIDNIIIATDYDREGELIGVEALKFIEPGYTNIRRAKFSALTSQEVKDAFDNLLDVNYGLADSAKAREEIDLLWGAVLTRFFSVTSNRLWKDFISVGRVQTPTLALIVEREEEITSFVPEKYFVINVTFNKGIDFQGVYEKNIKDEDEANKIFNAINGNDGIVKSYKNEKKEVYKPPPFSTTDFLREASRIGVTPSNAMKIAEKLYMSGLISYPRTDNTVYQRSIPLKSIAKKFEGTEFDNEAKMVLGQEKIYPSRGKVETTDHPPIYPVSYPKKALTGAYKNIYELIVRRFLATLYKNAVIEKSDADIDIKGYNFKSSGEKIIDNGWFDIYKYRKLREYKLPELVIGETVKGKKWNMEEKYTEPPKRYDVASLLKLMESLNLGTKSTRHDIIQKLNDRNFATGNPLRPTPLGIGFIKSITTIDSDIAKPDMTAELEKEMDKIAENQKKLDDVVNDSRNMLHSALKGFRGNKEEIKETITSYANKGDSIGTCPLDGGEISLIKFRNFSKIKCSTEGCKINFNLNATGLVQMTDKRCDVCSLPIIKIIRKGQSPEYRCVDPNCEYNRKKLSIGKCPSDGGDLIIRQSRYGKRFLGCSNYPKCTVTYPLPQKGVIMPTGEICRYCGAPLLIMVNGKRKWKFCPNMKCEYNRKDKVEKSESENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N502</accession>
    <name>A0A1V0N502_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FAD_1323</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142798.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N502"/>
    <dbReference type="STRING" id="74969.FAD_1323"/>
    <dbReference type="GeneID" id="31676815"/>
    <dbReference type="KEGG" id="fai:FAD_1323"/>
    <dbReference type="OrthoDB" id="56847at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 15 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="16">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="17">
        <location>
            <begin position="281"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ARD85187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="890" mass="102747" checksum="2A21200CD3A5ED52" modified="2017-06-07" version="1">MINRDTLVISNPGTGKTTMISNEVINLIKEGVKPEKILCITFTNNAVSELQKNIDKLLIANKIKNVTAYDVNIYTFHALAFQELFQSKAEKNIVSYNIARYLIYKKLRDLEAFNYGRDYVIEDIVPKLENAIRYIKSFGIMPVDIAKNRDMIMESLRRKYNSGIVRNIGLEEEEYLFDYFYQAFNYYEENKENPDFNDLLFQFQKLEDKKTYEYVFVDELQDVNDIESRIAMSTGNVKFLVGDRKQSIFGFQGGALSVFNSLIGNSGIEKKDLKINYRSTETILAYSKQYYLKFENDVPELENFRGTKEKGNKVKIVEVDSPEDSTLEIINSIPESSGNIGIIARTNSQIDTISSLLDRYNIDYSSDSNVHTINQAKKDITAFLKGILYDRPDDIINAMVTPFSGISLKEAFKIAESLRSEENTIDLFDSSNPFFSLRNKELSRENIMDLFESRIFPIASSISREYFLTAATVKSSIGEFFDAERDYTRKNFFDFLDLSYSENSSKSGNSRIILTTVHKAKGREFDNVIYLPKKPRKSDTYIDIIVSSIIEEIKQINVDDELKNESVRIDFVAFTRAKEELWVCTNRREAPNYLIPEYSEMVAYENIPEKQEITVPGKYNEAYLQFVSGDYNGAKETLSSKENWLKNIIYEFFQNKNVLSFSLISIDNPFFMLKNNILKLNEKTDALYYGLNAHEMAESLYKNEIKNELLGSGDKQILSNIESVVNQIKSGFNMEQIEAEVSAIARINQMFEEFSGEPDKIMFFGKIDAVFSDGKKYVILDYKTDKTTDRASHHRVQLLAYKILYSIKNNISPENIDTAIGYISMRGKINTHENTSGLIYKQPDKYSETSLKKYISRFLEYKSNPDKFIEDYLKQPSEDTLYERLAELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N504</accession>
    <name>A0A1V0N504_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142836.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N504"/>
    <dbReference type="STRING" id="74969.FAD_1349"/>
    <dbReference type="GeneID" id="84217961"/>
    <dbReference type="KEGG" id="fai:FAD_1349"/>
    <dbReference type="OrthoDB" id="56622at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="412" mass="44507" checksum="56ED4907CABA824D" modified="2017-06-07" version="1">MFSDSPDVVNRSFRYLLISRALRSSALIFVTLSLPLYLHFLHFSLVFISLIYIPIIIFNVVLVLILGRLGDKIGYSKILILGEAFPVVGLLLLAISTNIYVIAIGAIIAGITGGAGGMRGAFSPGMTAFIANNYPGEGNRVNRLSLLTATASFFSIFGGLFLSLYGIISSAIGILLFYRVFFIVSFLLVFGSLIALSRLHEYRRPKKTTKIMKKASFKYLLRIILPNSINAAAIGIAMPLLPLFFELKFHVDPGTVGNIYTIAYAATAIGSYTSGKFINGRVDSLKMASIAHILQGALFIIIAFTPFLFIATAIYVGRMAVAGIGSPMRGAINVRGIDKEDYGTSTSIQGVSGRGSQLTTGASGYLMDLNFAFPLLIGGAMQAAGGVLYYVLVKSWHPEKSSERRSETVKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N547</accession>
    <name>A0A1V0N547_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="5">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="5">MTA phosphorylase</shortName>
            <shortName evidence="5">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mtnP</name>
        <name evidence="7" type="ORF">FAD_1363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886462.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N547"/>
    <dbReference type="STRING" id="74969.FAD_1363"/>
    <dbReference type="GeneID" id="16024587"/>
    <dbReference type="KEGG" id="fai:FAD_1363"/>
    <dbReference type="OrthoDB" id="7681at2157"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000012">
        <property type="entry name" value="Probable 6-oxopurine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006334">
        <property type="entry name" value="PRK08564.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006599">
        <property type="entry name" value="PRK09136.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF3">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="50"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="5">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="257" mass="28638" checksum="70CE36C6D26C792D" modified="2017-06-07" version="1">MTYVGIIGGSGLYSIMETRKTMDIDTPYGKPSAPLEIGEINGVEVAFLPRHGKKHTIPPHMVNYKANIFALQKAGVQRIIGLNAVGSLKEEYKPGDIVIPDQFIDFTKRRDLTYYNGPDVYHISMADPFCSDISAKAYEAGKKLSFPVHKNGAYICIEGPRFSTRAESKMFRNFADIIGMTLVPEINLAAELSMCYGMLATVTDYDAWKDEAVEASDVMQIMKESEEKVSKMLYNLVPEINGQRNCKCSLRLENAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N567</accession>
    <name>A0A1V0N567_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142896.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N567"/>
    <dbReference type="STRING" id="74969.FAD_1424"/>
    <dbReference type="GeneID" id="31676916"/>
    <dbReference type="KEGG" id="fai:FAD_1424"/>
    <dbReference type="OrthoDB" id="372177at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="351" mass="39450" checksum="50CF8ED37D47D082" modified="2017-06-07" version="1">MEKKSQFKTIREGAVELMAPDNLIIKGPGTRTAGFYNMDQKLNRDITISFLRTVKPKIALDAFGGTGVRGIRINREAGIKAVISEINKKSYEYININRELNNSPVEVYNKTFQAILNDYLFDYIDIDPYGSVLPYMDDAMINIRNRGYIGVTATDLTSLTGSMPAKTLRRYRAFVINDIYRHESGIRLLIGEIVKRAAALDKAAIPMISLWHSHYYRIIFQIISSSSKADAQLDQVGMFDRHSGLSGVYPSSREGPLWLGNLNSDIAQKLDYTEDPDKQFLSTIERLKTNDLSLYFADIADFARISGKDTKSIESSMLKLRDAGIECGRSMFSNTGIKVSSTVPEAFNIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N574</accession>
    <name>A0A1V0N574_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886501.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N574"/>
    <dbReference type="GeneID" id="16024627"/>
    <dbReference type="GeneID" id="31676880"/>
    <dbReference type="KEGG" id="fai:FAD_1388"/>
    <dbReference type="OrthoDB" id="135877at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050624">
        <property type="entry name" value="HTH-type_Tx_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43479">
        <property type="entry name" value="ACREF/ENVCD OPERON REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43479:SF11">
        <property type="entry name" value="ACREF_ENVCD OPERON REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="Tetracyclin repressor-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="194" mass="22272" checksum="B3E0D28EF3DDA98F" modified="2017-06-07" version="1">MPKVIQDYREMAKEKIIESASKLFFQMGYNNAGMENIARDMGITKGTLYLYFKNKEELLNKTCKVNMDLLETNLKKSVSGNMITGIEKFFADEMKLPDYKKFYWIFALNEINVNNNIKEIIENSYKRYVKYISDLIENLKQDGTISESINSTDLARILIAFHNGVLISIMQGLDNPTATSIFNSGIRSLFGNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N578</accession>
    <name>A0A1V0N578_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886518.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N578"/>
    <dbReference type="STRING" id="74969.FAD_1408"/>
    <dbReference type="GeneID" id="16024644"/>
    <dbReference type="GeneID" id="31676900"/>
    <dbReference type="KEGG" id="fai:FAD_1408"/>
    <dbReference type="OrthoDB" id="56622at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="379" mass="42922" checksum="2DB0D3F17DE764FE" modified="2017-06-07" version="1">MKAQSYFISVSKASRSFILSMLAVITPFYLSKFVNVFDVGIIVLFSIAFSTLIIYVFPALNIKNWLKMYAISAALAIALLLNFIFMNFYVFIFSLMLGSISLSGRDISPNQPIEQYAMAHYETDMKSKRMAFSLYNFFSYGASIIASLFLFFYVNIDYRIVFLLLTLVALCQFVLYLFIRFPQHKRMKGKDLDVETKKRVFSLSYLFAMDSFAGGMVTVSMISLYFKYVYHISLSTAGLIFVAVNIITTISILISPLISSKIGLIRTMVYTHSVSNIFLMLVPVIHVLAISEIFLFLRQTTSQMDVPARDTLINTVIEENYRVNSNSIFSAVRNGALIPGPGIVGAVMTVFPPFMFFAGGALKLSYDIIFFVKYRKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N580</accession>
    <name>A0A1V0N580_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IS605 OrfB family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142877.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N580"/>
    <dbReference type="STRING" id="74969.FAD_1401"/>
    <dbReference type="GeneID" id="31676893"/>
    <dbReference type="KEGG" id="fai:FAD_1401"/>
    <dbReference type="OrthoDB" id="57553at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="5">
        <location>
            <begin position="201"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="6">
        <location>
            <begin position="337"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="461" mass="53938" checksum="6781204B2FC8B82D" modified="2017-06-07" version="1">MIEAKRNKIKNSLRITKERRKTQDVIILKLKIDNDKLNNNTIKALNTIFLEAKWLYNYVINKEFNNDIFNIDSKIKNVNVYVKDHYETRELKYLSSQMKEEIINRGIDNIRGLHKLKEKGFKIGKLKFKSFITSIPLNQYTITYKIINNNYIKIQNIKQLLKVNGLDNLECYYEPANALLINNNNNYYINITAYKNKYILEKPVNNQKIISFDLGIKNQLTCSNGSILNYNIPKSKKEIRLQRSLSRKAKYAEGSKNKLSKKQSRNYYKTKNRLNREQAKTTDKRKDTINKIVHYLTSNYDIVITQNDNISGWRRLFGKKIESTGIGGIIDALKHKASTLILIDRFIPTTKECSKCHNKYDIKLDERIYQCHNCGFIIDRDYNSSLNMIYYGIIKLNELLKIKNKKLNSYFKKYNININVPMEHRELTPVEIIASGFEGLNISPYVKLSMVNEAGSLYALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N593</accession>
    <name>A0A1V0N593_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886516.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N593"/>
    <dbReference type="STRING" id="74969.FAD_1405"/>
    <dbReference type="GeneID" id="16024642"/>
    <dbReference type="GeneID" id="31676897"/>
    <dbReference type="KEGG" id="fai:FAD_1405"/>
    <dbReference type="OrthoDB" id="40462at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="139" mass="16128" checksum="75470E8280F1AF97" modified="2017-06-07" version="1">MECMAAVALIFNRDKFLLIKRAEQDGDPWSGQMALPGGHRERNESCEQAAIRETMEEVGLPITVKRSLGIYHTLNGNVSVEAYECFSTETAIHPDNEISKYFWATREELMHKNETYKFRDYIVFGLTYRILYDYFSSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N596</accession>
    <name>A0A1V0N596_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N596"/>
    <dbReference type="STRING" id="74969.FAD_1407"/>
    <dbReference type="KEGG" id="fai:FAD_1407"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="30"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="436" mass="48206" checksum="420EF63EF6F3F55B" modified="2017-06-07" version="1">MHKMHLCTFSFNIIDLAFMETEYPQGNSGISKIMLTSLFIDEWNIFSIPMISIFVEHSLRFGTTMLGLVTGATIGGASIGSVLGGYMVDRFGRRKLFFFNLILFLISAILSALSINLTMLVIFRFLAGIPAGADIANVYSYIMETEKPGHREVTGAYNTLMASVAILGLNGSVVILLISGLKATAIWKIAILIQIIPVLFLLLSYKRIPESDIWKASNKEATYIDFFRKLRHNRVQWRTSMYSWCCGIASGIEVGTFAFFIPYIILKFGISGAINDRFIIIGIYSIGIPAGYLGPKILPKIGLRKLSYSGFALSFAGLVISGLALLFNIYIVLPVSMMIFVWGNHWNNEPITTSQALVADSDMRGKAVGISNFIYQLPSFLSISIFPIMFSAIGMGYSTLVVAIASFSGIVITLFVFREIFGYRNDATYDSECVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N598</accession>
    <name>A0A1V0N598_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15 16">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="15">ATP-PRT</shortName>
            <shortName evidence="15">ATP-PRTase</shortName>
            <ecNumber evidence="5 15 16">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hisG</name>
        <name evidence="18" type="ORF">FAD_1454</name>
        <name evidence="19" type="ORF">HLB00_01385</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Berkeley</strain>
            <strain evidence="20">Y</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5 15 16"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000038">
        <property type="protein sequence ID" value="NOL59490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142917.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N598"/>
    <dbReference type="STRING" id="74969.FAD_1454"/>
    <dbReference type="GeneID" id="84218046"/>
    <dbReference type="KEGG" id="fai:FAD_1454"/>
    <dbReference type="OrthoDB" id="33116at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000008">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01018">
        <property type="entry name" value="HisG_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF10">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="17">
        <location>
            <begin position="46"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="NCBIfam" id="TIGR00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ARD85312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="NOL59490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="210" mass="23553" checksum="7B6A59891B6B0B11" modified="2017-06-07" version="1">MKFVIPKGRLMNDSLAFLQNAGIKINIDDDRKLMFYQDGNEIILPRARDVPVYTEYAGDIGICGSDTLSESRSRLFTPLTLNFGKCRLSLIAPEKYSIKDFEGLDIATKHPNITRDYFFSMGIDANIIPLNGSLELAPETGIADAIVDVVQTGETMKKNNLVEIQKIMDISAILVVNRVSQKIKYKEINNFIEKAGGLNGNRRVCKKYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5C8</accession>
    <name>A0A1V0N5C8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1447</name>
        <name evidence="10" type="ORF">HLB00_01350</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000038">
        <property type="protein sequence ID" value="NOL59483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142910.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5C8"/>
    <dbReference type="STRING" id="74969.FAD_1447"/>
    <dbReference type="GeneID" id="84218039"/>
    <dbReference type="KEGG" id="fai:FAD_1447"/>
    <dbReference type="OrthoDB" id="56891at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="459" mass="51918" checksum="27C4265C97F075A7" modified="2017-06-07" version="1">MVSRKMNPERKIYGTYSNRDFNNPVPEFEFPEEGMASRAAYEMIHEELKLDGIPELNLATFVTTYMEPEAKNLYMENAHKNFIDSFEYPQIKKEETRIVNILSRLYNAPEGKDFTGTSTIGSSESIMLALLAHKWNWKSKMEALKKDTSKPNIVFGADTHVVWDKFAKYFDVEARVVPLDANTKVVDPEKLIENVDENTIAVGAVLGTTFTGAFDDVKRINSLLEELKSKKGLDIPIHVDAASAGFITPFIEPELEWDFRLSHVKSINVSGHKFGLVYPGIGWLLFKDKADLPDDLVFYVNYLGDDMPTYTLNFSKSAANIAPQYYNIIRLGKSGYRNIAENIMKNAKYLADKIGEFPELEVVSRAEHIPVVTFRQKKAGSYTLFDLSAAIRSYGWIVPAYSLPDNAKDTVLMRVVVREGFSRDLADIFLENLQQSMERLSGKGIEKSKISSRRGHAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5E6</accession>
    <name>A0A1V0N5E6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium-dependent phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5E6"/>
    <dbReference type="STRING" id="74969.FAD_1510"/>
    <dbReference type="KEGG" id="fai:FAD_1510"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="287" mass="31339" checksum="C95A2406021C6B38" modified="2017-06-07" version="1">MLTLLVSGNNLSAAVGTLVGSRIVGRYGGVIIGAGGFFLGLVLEGRFLHGAALSLIPHSYFYITYAFLVSFLIFLFANIGRAPLSLTMALAGTALGIDVRIGRLIDYKFVILMVAFWVIAPVISIVVSYFAEKGIFRRNFKNVWNVARWLKFLIVISSFLTAFTLGANTLGFIANVEGFNFLTITVMTVAIFSGAFFLSSGVIKRVGEEMYSMRYSNALVSLVVSSLLVEIATFFAVPLSNTQTLTSSVFGVGISYKYKAIYMRPFLIIILTWILSPSIGFILGYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5I5</accession>
    <name>A0A1V0N5I5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886693.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5I5"/>
    <dbReference type="GeneID" id="16024822"/>
    <dbReference type="KEGG" id="fai:FAD_1553"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="129" mass="14445" checksum="97701567B6881FEE" modified="2017-06-07" version="1">MAGILYDIMIESVSLFGIIFWIVLSIVLFLVYRMYISNKKAIISSIVIGRIFTILSIYPVNSIVIKSICPGPGYGQFYPLTFMIFISFINGFAFSLIIYYFYNSKIAIKIGILTFAILFLAINIAAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5J8</accession>
    <name>A0A1V0N5J8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Metal dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1554</name>
        <name evidence="3" type="ORF">HLB00_00950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886696.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5J8"/>
    <dbReference type="STRING" id="74969.FAD_1554"/>
    <dbReference type="GeneID" id="16024825"/>
    <dbReference type="KEGG" id="fai:FAD_1554"/>
    <dbReference type="OrthoDB" id="73420at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16272">
        <property type="entry name" value="RNaseZ_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="252" mass="28668" checksum="6A2F4932CC11C200" modified="2017-06-07" version="1">MQIKFLGNWSSHIQAGKRNVSIIIDGHIVLDCGPHTIESMLENGIDPAKIDKMLISHMHLDHYGGLAEILWYRGARNVKDELTIMGPKGIRKNTEKILQIYNTPDNYMFSVKPNYVEINNNGEVYEIKTEFIDKSENDYIEAFSGNHIIPDNMYRLEYRGNTIAYTGDTAYNDNIPLLGENADILLHEMTYTDKDAEIAKFWKHSTYSSAIKGFGESHAKKLVPVHLTDETVSVLKAKYSENIILPFADINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5M5</accession>
    <name>A0A1V0N5M5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074036.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5M5"/>
    <dbReference type="STRING" id="74969.FAD_1546"/>
    <dbReference type="GeneID" id="16024815"/>
    <dbReference type="GeneID" id="31677037"/>
    <dbReference type="KEGG" id="fai:FAD_1546"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="129" mass="15217" checksum="6E4BAB39D7B4137F" modified="2017-06-07" version="1">MPSRSMDWLKQAKRDLEEAEGSLNNEKYEWACFASQQSAEKAVIALYHSINKEIWSHSVSRMLLQLTEFDIDKSLADKAMELDRVYIGSRYPDYYTEGSPFEYYSIEDAKRCLNYAKEIFEFCNKNIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5P8</accession>
    <name>A0A1V0N5P8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Shikimate kinase</fullName>
            <ecNumber evidence="4 14">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FAD_1608</name>
        <name evidence="17" type="ORF">HLB00_01625</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Berkeley</strain>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="4 14"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000043">
        <property type="protein sequence ID" value="NOL59536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886741.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5P8"/>
    <dbReference type="STRING" id="74969.FAD_1608"/>
    <dbReference type="GeneID" id="16024874"/>
    <dbReference type="KEGG" id="fai:FAD_1608"/>
    <dbReference type="OrthoDB" id="9602at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010189">
        <property type="entry name" value="SK_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01920">
        <property type="entry name" value="Shik_kin_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF3">
        <property type="entry name" value="SHIKIMATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="15">
        <location>
            <begin position="49"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="NCBIfam" id="TIGR01920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD85453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="NOL59536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="272" mass="30383" checksum="64B3DB17B413C480" modified="2017-06-07" version="1">MIIKTNGGLSVLSAFVNGYGAAISIDLPMYTEIKKSGEDIFPTPEMADTVNFLRNRFSIHDKYSININSQIPMGMGLKSSSAMTLSLIYGIFKINHMDIAPQEVLKIASEASIHNKTSVTGAIDDLSIAYYGGFCFTDNSSNRIISKQQIEEKYIILELQDRMALTYDMRNRDFSGYKNYYGRLLELVKDGHIFESMMLNGYIFSDGTETGIVKKMLGTGAIYAGRSGKGPAIFGIYETESSMESSFKQLTSEGYNVIRSRFNNYGINIYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Q5</accession>
    <name>A0A1V0N5Q5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1588</name>
        <name evidence="3" type="ORF">HLB00_01520</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000041">
        <property type="protein sequence ID" value="NOL59516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142972.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Q5"/>
    <dbReference type="STRING" id="74969.FAD_1588"/>
    <dbReference type="GeneID" id="31677078"/>
    <dbReference type="KEGG" id="fai:FAD_1588"/>
    <dbReference type="OrthoDB" id="168808at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236:SF1">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH bat-type" evidence="1">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="215" mass="24684" checksum="FEEEB9E84E6A5B1B" modified="2017-06-07" version="1">MYFLSVHVAGDCSLSKSTENNESKIIISNIYNMRDSANSLIAYSIGSDINNIYRRDFSTIRFIKGKYANMFIGTKKGHNIMQAINESGGIPMYPFIAFNGGESYFIMHFDKSSMMRDLELIEKNNKIKYFDYTSVSSGDSIMDISRNLNQEMNMMRLTPTEKKIIQEAYNSGYLDWPRTTSLDDIARRFSISKPTALLHIRNAEKKILSCFIARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5R2</accession>
    <name>A0A1V0N5R2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142978.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5R2"/>
    <dbReference type="STRING" id="74969.FAD_1599"/>
    <dbReference type="GeneID" id="84218194"/>
    <dbReference type="KEGG" id="fai:FAD_1599"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="447" mass="49845" checksum="DE3EAC5237593356" modified="2017-06-07" version="1">MLSVHKRIDELPVSPFLLKITLLSSMGIFMDGYVLSIYSIAILYMRDYFHLVSGTPFYVYYIAFMGSSLFIGMFFGSIILGNLSDKYGRKKIYEYDLIITMVFLIMSGISTNILEFIIFEILAGVGIGADYPISSSIQAEFSPKNKRGKFLVFNIFSWTIGGVVLLLVAIPVILYIPAAINWRILYLTGAIIPFFVILSRRNLPESPFWLTGKGKDSEALKSSNYLGKSAGMEVDELPVVESGNSKIRDLFSKKYLYYTIFVSVAWFSYDVSSYGVWEYTPSAFAYSNSNIVMVVLATLLEELPVFIGFLICMYYVEKTGRKSLELIGFGGAAVSLIIFAAVSNFIALGILLTFFAFATMHLFHNMGPTNLTYDYPVEIFPTRIRGTAMGFATSVSRVGAIVGTIAFPIILFTLPFTFVLIFLVVFEVIGFSITFLLAPETKGKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5S4</accession>
    <name>A0A1V0N5S4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation initiation factor IF-2 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143000.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5S4"/>
    <dbReference type="STRING" id="74969.FAD_1656"/>
    <dbReference type="GeneID" id="31677145"/>
    <dbReference type="KEGG" id="fai:FAD_1656"/>
    <dbReference type="OrthoDB" id="84794at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
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    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
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    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003064">
        <property type="entry name" value="PRK03987.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="253" mass="28736" checksum="9B1EAFA024D5B1D6" modified="2017-06-07" version="1">MSRDMPEPGDLVVVTIKEVQNYGAIVQLDEYPGVSGFIHIAEVATGWIKHIKDFVRVNQRTVCKVLNVDSNRRHVDLSLKRVNEHQKREKIEEWKNDQKSEKLLEIVAKEANISDKAITKNMEDYLVSEYGSAYDAFFEAASNKEFMSDKNEPWKDAFIKVAKENISIPMVKIGGEIDMYSLASNGIELIKEALDVGSGNNVEITYAGSPKYRISIVDEDYKSAEEKLKNVLEKISTACKKNNISYSFTRDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5W4</accession>
    <name>A0A1V0N5W4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="5">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_1632</name>
        <name evidence="16" type="ORF">HLB00_02430</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Berkeley</strain>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000074">
        <property type="protein sequence ID" value="NOL59690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_171481328.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5W4"/>
    <dbReference type="STRING" id="74969.FAD_1632"/>
    <dbReference type="GeneID" id="31677121"/>
    <dbReference type="KEGG" id="fai:FAD_1632"/>
    <dbReference type="OrthoDB" id="23624at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504:SF1">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="14">
        <location>
            <begin position="17"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-succinyllysine" evidence="13">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604439-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="NOL59690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="369" mass="41516" checksum="C51C96D0EE034784" modified="2017-06-07" version="1">MYIEFTDSGMVVPDVLTIGYIDGDGIGPEITGAMIGVVNSAIELAYKGSRSIEWHKILIGTEAYEKFGTYVPEDSIKEIQKMYIAMKSTLNFMPDKRDLNTILRKRLGLYSNIRILKYIEGMDIPVNTFNRLNLTIIRDSTPNSHIFYHSSESTDDLIRFISDNYGLNITPDSGIYMMPQSKFRTRKIAKQAVRYSRRNGKKKITILESQQNHEFANWCIEEASAQEDVGYEVVKTREFMKRLIASPEDFEVILVDNVLSQTLVDYLAGTINIEYGSSIGDECAVFEAVQSSLPSEAGYDAADPLSFILSGCEMLMHIGWVEAAQIIEKAISAAFKDNKIPKDINTRPDISPIKCSEFSSEIIKRMNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Y2</accession>
    <name>A0A1V0N5Y2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Antitoxin SocA-like Panacea domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Y2"/>
    <dbReference type="STRING" id="74969.FAD_1685"/>
    <dbReference type="KEGG" id="fai:FAD_1685"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="21569" checksum="355D2A8B29A4C631" modified="2017-06-07" version="1">MEYLRYMVSRSDLLLSFIYAWGKSKKNNESIPSVTHLQKEIFLLCRRTPFIDMKEIYHFEPLWYGPFSKELSGDLTDFQSRGLISFDELRLTNRGFKIAASVWNNLSDFEKQQIYYVKSTFNYMSLKELLDTVYSRYPKFTKRSALKKEVVDKYFAEFLQENKITEEDVVSAVNLAKEALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Y5</accession>
    <name>A0A1V0N5Y5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxiredoxin</fullName>
            <ecNumber evidence="9">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_1702</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homodecamer. Pentamer of dimers that assemble into a ring structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886843.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Y5"/>
    <dbReference type="STRING" id="74969.FAD_1702"/>
    <dbReference type="GeneID" id="16024974"/>
    <dbReference type="GeneID" id="31677193"/>
    <dbReference type="KEGG" id="fai:FAD_1702"/>
    <dbReference type="OrthoDB" id="6924at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00401">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022915">
        <property type="entry name" value="Peroxiredoxin_TDXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009670">
        <property type="entry name" value="PRK13191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="9">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="231" mass="26605" checksum="A9240B7771D453DC" modified="2017-06-07" version="1">MENRMPLIGEKFPEMDVVTTQGSKKLPDDYKGKWFVLFSHPGDFTPVCTTEFFSFAQRNDEFTKLNTELIGLSVDSKISHMEWINWIHDNLKIDVKFPIIADPMGNVAKSLGMIHAESATSTVRAVFIVDDKAVVRAILYYPLEIGRNISEILRMIKALQMVDKYKIATPANWPDNELMKGRFIIPPPATMNDIPERLKKYKGYAWWLTYRDAPEEEVKEAKEVSRMKEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N666</accession>
    <name>A0A1V0N666_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sodA</name>
        <name evidence="9" type="ORF">FAD_1811</name>
        <name evidence="10" type="ORF">HLB00_01825</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000045">
        <property type="protein sequence ID" value="NOL59574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841539.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N666"/>
    <dbReference type="STRING" id="74969.FAD_1811"/>
    <dbReference type="GeneID" id="16025090"/>
    <dbReference type="KEGG" id="fai:FAD_1811"/>
    <dbReference type="OrthoDB" id="32917at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="8">
        <location>
            <begin position="96"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="207" mass="24105" checksum="E79A8883C594AD06" modified="2017-06-07" version="1">MATETWEVKENAKPRGLDGISDKQIDYHFDVHYKGYVSKLNEIWSKLPDVDLTKANQNYSDLREMKLEETFNYDGSMLHEYYFESLSKDHVAMPESVKAQIEKDFGSYEKFVALFKATGTAFRGWAHLVFDLNCGKLRVLGADIHNASAIWNALMILPLDVYEHAYYTDYGAKRAPYLDAFMNNVNWKVVEKRLDRAKRTYEAFKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N679</accession>
    <name>A0A1V0N679_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-guanine(15) transglycosylase</fullName>
            <ecNumber evidence="7">2.4.2.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">7-cyano-7-deazaguanine tRNA-ribosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Archaeal tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tgtA</name>
        <name evidence="11" type="ORF">FAD_1747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanosine(15) in tRNA + 7-cyano-7-carbaguanine = 7-cyano-7-carbaguanosine(15) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:43164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10371"/>
            <dbReference type="Rhea" id="RHEA-COMP:10372"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82850"/>
            <dbReference type="EC" id="2.4.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeosine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.48" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074045.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N679"/>
    <dbReference type="STRING" id="74969.FAD_1747"/>
    <dbReference type="GeneID" id="16025022"/>
    <dbReference type="GeneID" id="84218368"/>
    <dbReference type="KEGG" id="fai:FAD_1747"/>
    <dbReference type="OrthoDB" id="6871at2157"/>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002099">
        <property type="term" value="P:tRNA wobble guanine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21149">
        <property type="entry name" value="PUA_archaeosine_TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="entry name" value="ArcTGT, C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01634">
        <property type="entry name" value="TgtA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050076">
        <property type="entry name" value="ArchSynthase1/Queuine_TRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004804">
        <property type="entry name" value="TgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00432">
        <property type="entry name" value="arcsn_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46499">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46499:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="9">
        <location>
            <begin position="10"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-guanine transglycosylase patch-forming" evidence="10">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="550"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="625" mass="71585" checksum="5DEEF5321DF48A4F" modified="2017-06-07" version="1">MQMFFREGLARIGKFSTPHGDIETPTVMPVINPNLNFLTKEELKSIGVQAVITNSYIIKRTASLEQDALKHGVHRLINFDGPIMTDSGTFQSYVYGDIEYGNKEIVQFQKDIGSDIITILDIFTKPQDSYEQAKAAVYETSRRLQEVNTPDSIIAGPIQGSIYPDLRRESARLMSEASYLPIGGVVPLLESYRYSDLVNIIINSKLNSDFSKPVHLFGGGHPMFFAFSVLLGVDIFDSASYIKYAKDNRVLYTEGTRNLKEIRDFPEWSPLFNKYSPVELIKADEKTRLKLLSLHNLKAIFNEITEIKERIYENTLYQYVEEKSMAHPALYRAYLEMLDHNLEPFWNISLKSPLYFFNSSTYKNTFIKRLVKFTEDYISNGKKTVLVSYRQWRHGFPVSDDILRSYETTDYNFLIEWNDIFIPMELENTYPVSQMVPSGVLDKIYRDDYIAWLKSINNDISFYDPSITGSEKIRNYSHSKINEVFHLQFKARKNLFVNSDKIIKSKATGHIRNIKRGEKIIATMRNDGFLTLSIYGGKLLNDMLDFPASRVIVTDDSGEFNSQGYNVFFKFVEDCDREIIAGNDVMVTSASGDLYAVGHATVSGKEMGFYRNGIAVKVHEGINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N691</accession>
    <name>A0A1V0N691_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143077.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N691"/>
    <dbReference type="STRING" id="74969.FAD_1766"/>
    <dbReference type="GeneID" id="31677257"/>
    <dbReference type="KEGG" id="fai:FAD_1766"/>
    <dbReference type="OrthoDB" id="4907at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05234">
        <property type="entry name" value="UDP_G4E_2_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="318" mass="35753" checksum="8C5EE7E563F71013" modified="2017-06-07" version="1">MQGKNILITGGAGFIGSNMVEKLLPDNNITVLDNLNNHVGNRFITQFMENKNFHFINTDLLSFDYGSLKGIDTVIHFAANSDVRYGSQDPTKDFQNNVVATENILEYMRKYDVKDILFASSSTVYGEASIMPTPENYGPYMPISSYGASKMSNEGFITAYSHYYGFKGSIFRFANIVGKNSTHGVIYDFINKLLKSPDELEILGDGTQKKSYMHVKDCVDSMIYVHEKLTRTDIINLGNRETTSVKTIADYVVKRMGLKNVKYRFTGGINGRGWKGDIKITHLAIDKLLSTGWKSRYTSDESVDVAVQETIDQLKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N695</accession>
    <name>A0A1V0N695_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA sulfurtransferase</fullName>
            <ecNumber evidence="10">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiI</name>
        <name evidence="14" type="ORF">FAD_1813</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + ATP + H(+) = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + 2 oxidized [2Fe-2S]-[ferredoxin] + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ThiS sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [ThiS sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="Rhea" id="RHEA-COMP:19908"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143103.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N695"/>
    <dbReference type="STRING" id="74969.FAD_1813"/>
    <dbReference type="GeneID" id="31677303"/>
    <dbReference type="KEGG" id="fai:FAD_1813"/>
    <dbReference type="OrthoDB" id="372227at2157"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA-uracil-4 sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002937">
        <property type="term" value="P:tRNA 4-thiouridine biosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11716">
        <property type="entry name" value="THUMP_ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054173">
        <property type="entry name" value="ThiI_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049962">
        <property type="entry name" value="THUMP_ThiI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050102">
        <property type="entry name" value="tRNA_sulfurtransferase_ThiI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43209">
        <property type="entry name" value="TRNA SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43209:SF1">
        <property type="entry name" value="TRNA SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22025">
        <property type="entry name" value="ThiI_fer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="13">
        <location>
            <begin position="54"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="389"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="10">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD85652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="473" mass="53647" checksum="E7413181882786FD" modified="2017-06-07" version="1">MFIVRYSEIGLKGNKTRRNMEKLLIENIISSLPEDSGLKYKKSDGRIYLYSDSPELMNILPDIFGVKSFSRANEYTFNTIEDIVTRCVENYYSYVKNKTFAVRVTRKGTHNFTSKDLEIAIGNKLYDNSSGVNLESPEAPIYIEVRDKNFYTFTEKMEGPGGLPLKSEGIAISLFSGGIDSPVATFMVMKRGMATDLLFCSLAHPSDTLYMLKAARNLLFRYSYGYNSNIYILDGTSLITGILRNPEQKYANLIFKKLLYSYAEGLCQENDYDAIVTGESIGQVSSQIPKNLKSLSYGINTPLFRPLIGFDKEETINYSKRKGLYMDESIGEFCSLFSKNPGINTAYRDLKPEVEKFPLKEILHEIIKIKKDEIDDYVNSINNSKSDTIPENSIIIDLRDNKDFDLWHVPGAINMPVSSIDSLAESGNPDKNYFFYCKKGLNSAYAASIMRSHGYNSFYSTEKDIKKMDAIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6A6</accession>
    <name>A0A1V0N6A6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dinitrogenase iron-molybdenum cofactor biosynthesis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1854</name>
        <name evidence="2" type="ORF">HLB00_05550</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000186">
        <property type="protein sequence ID" value="NOL60297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887003.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6A6"/>
    <dbReference type="GeneID" id="16025137"/>
    <dbReference type="KEGG" id="fai:FAD_1854"/>
    <dbReference type="OrthoDB" id="55683at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13125" checksum="76081F9176DE6D2E" modified="2017-06-07" version="1">MKVACVVDEENMLSPLEYGNSIFLIDDETKKIEEYENPGFGRTHGGREVAMAGILSLKPDMFVVTENSLCPGSYNMSLGKVKYVVTEEKPISDVIKNLKELEGKAVEELEPVLYREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1H7</accession>
    <name>A0A1V0N1H7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_0008</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="1"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141235.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1H7"/>
    <dbReference type="STRING" id="74969.FAD_0008"/>
    <dbReference type="GeneID" id="84218499"/>
    <dbReference type="KEGG" id="fai:FAD_0008"/>
    <dbReference type="OrthoDB" id="371997at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002095">
        <property type="entry name" value="PRK00934.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="144"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD83944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="287" mass="32603" checksum="1D954B151C342419" modified="2017-06-07" version="1">MYIVPSSTAYNVSRKLASIFSCNVSGVVRKRFPDNEMYLKIIDDVKGEDVLLVGNTRSDQDIIEYLLLLDAIKEEEPKSITAVVPFFGYARQHMRYNNGEPVSSKVFTQAINQYADRIITVELHDEQTLNYSKVPFTDIKIINPIYKYFMDKNIDFVISPDDGGYERVKLMGSKLGIPAYYIDKKRIDSTTVKMTLPEEDYKDKNILILDDIISTGGTIIKASRMLKDKGVRNIYACAIHGVFANNSNEKIERYVNELTVTDTIETKYSNITISGEIAESLKDKISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1I7</accession>
    <name>A0A1V0N1I7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Methionine aminopeptidase</fullName>
            <shortName evidence="8">MAP</shortName>
            <shortName evidence="8">MetAP</shortName>
            <ecNumber evidence="8 9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">map</name>
        <name evidence="11" type="ORF">FAD_0019</name>
        <name evidence="12" type="ORF">HLB00_05675</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8 9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000190">
        <property type="protein sequence ID" value="NOL60322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887030.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1I7"/>
    <dbReference type="STRING" id="74969.FAD_0019"/>
    <dbReference type="GeneID" id="16025165"/>
    <dbReference type="GeneID" id="84218509"/>
    <dbReference type="KEGG" id="fai:FAD_0019"/>
    <dbReference type="OrthoDB" id="372008at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01975">
        <property type="entry name" value="MetAP_2_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028595">
        <property type="entry name" value="MetAP_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="10">
        <location>
            <begin position="12"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL60322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="291" mass="32450" checksum="1E9007A77734E0E3" modified="2017-06-07" version="1">MDADVKNKYILAGKIGRDALEYAQTLIEPGALFYDVAEKAEQFIRDKGAVPSFPVNLSINNEAAHYTPYEGDKKKFKTGDLVKVDLGAMVDGYMSDNAATIEVGNTGNYSDLIDATRDALNSAIKILRPLINIYRIGEEIGNVITSRGFNPIKNLGGHGINRYDLHSEIFIPNYDDGNDETIKTDKVIAIEPFASTGIGMIHSGQMGNIYIIDKPGVRDRDEILYKNFNTAPFAERWVSRLMKNDQEYIRKKMSTKYVSGFPVLKEHSKSMIAQSEHTIMVLGDEIIVTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1K2</accession>
    <name>A0A1V0N1K2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141329.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1K2"/>
    <dbReference type="STRING" id="74969.FAD_0097"/>
    <dbReference type="GeneID" id="31675609"/>
    <dbReference type="KEGG" id="fai:FAD_0097"/>
    <dbReference type="OrthoDB" id="57250at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="80" mass="9451" checksum="2B20537776D19379" modified="2017-06-07" version="1">MVKAFDINNFNERKQFEIRLQIALLHNTLKIKANSKNPDKYDEYIEERIEKIRALVDTTAKFTITDKDKVIYSSETIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1K8</accession>
    <name>A0A1V0N1K8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-ribbon domain-containing OB-fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0052</name>
        <name evidence="4" type="ORF">HLB00_02635</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000084">
        <property type="protein sequence ID" value="NOL59730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141268.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1K8"/>
    <dbReference type="STRING" id="74969.FAD_0052"/>
    <dbReference type="GeneID" id="84218543"/>
    <dbReference type="KEGG" id="fai:FAD_0052"/>
    <dbReference type="OrthoDB" id="9573at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="ChsH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="ChsH2_Znr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052513">
        <property type="entry name" value="Thioester_dehydratase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34075">
        <property type="entry name" value="BLR3430 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34075:SF5">
        <property type="entry name" value="BLR3430 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_ChsH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="zf-ChsH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChsH2 rubredoxin-like zinc ribbon" evidence="2">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="ChsH2 C-terminal OB-fold" evidence="1">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD83987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="134" mass="15232" checksum="79625D7EB4F506F7" modified="2017-06-07" version="1">MTELSRIWRETEYRYNLIGFKCKNCGNSYFPPRDVCPVCHRESIGKMEKVKFSGNGEVISYTVVHDAPPSFKRQVPYVLALIKLSEGPVITAQIVDCDPADVDIGKKVHSVFRKIRQDGDSGIIEYGYKFVLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1L4</accession>
    <name>A0A1V0N1L4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit Rpo4</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpo4</name>
        <name evidence="1" type="synonym">rpoF</name>
        <name evidence="2" type="ORF">FAD_0046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141264.1">
        <property type="nucleotide sequence ID" value="NZ_JABGBP010000086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1L4"/>
    <dbReference type="STRING" id="74969.FAD_0046"/>
    <dbReference type="KEGG" id="fai:FAD_0046"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00864">
        <property type="entry name" value="RNApol_arch_Rpo4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010924">
        <property type="entry name" value="Rpo4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005053">
        <property type="entry name" value="RNA_pol_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="102" mass="11764" checksum="9F257D4A476D8675" modified="2017-06-07" version="1">MKITYKTNNEVFNMLSNVEERTPSENDTLAYVEKFLKYDKDADLKQLYNDISKVHKLPREAIVKIIDIKPSSTEELMAILNSYNVAADNKVLDSILDILRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1N8</accession>
    <name>A0A1V0N1N8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indole-3-glycerol phosphate synthase</fullName>
            <ecNumber evidence="4">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_0100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141332.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1N8"/>
    <dbReference type="STRING" id="74969.FAD_0100"/>
    <dbReference type="GeneID" id="31675612"/>
    <dbReference type="KEGG" id="fai:FAD_0100"/>
    <dbReference type="OrthoDB" id="15223at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="11">
        <location>
            <begin position="9"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="237" mass="26821" checksum="7006D59CF02501D9" modified="2017-06-07" version="1">MIVDEIYSKNSERKLQEFNMRERGIISLKDALEKNQNGPGIIAEYKRKSPSGFSNKSNTDILKYFDGIQRIIAGISILTEAQYFGGTPLDAEAVQCYNKPILIKDFISSESMIKSSYMSGGDAFLLICDFLDYNRIKKLVQYGKKIGMDALVEVHDPASAKNIFPDENVILGYNRRNLKTLKMEDNSEEMYDNLKSYGLPVVLESGINHENINKLHIEKYQGLLIGSSLLSGDTIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1R1</accession>
    <name>A0A1V0N1R1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Small ribosomal subunit protein uS19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps19p</name>
        <name evidence="9" type="ORF">FAD_0162</name>
        <name evidence="10" type="ORF">HLB00_02230</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000069">
        <property type="protein sequence ID" value="NOL59651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887167.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1R1"/>
    <dbReference type="STRING" id="74969.FAD_0162"/>
    <dbReference type="GeneID" id="16025311"/>
    <dbReference type="KEGG" id="fai:FAD_0162"/>
    <dbReference type="OrthoDB" id="30559at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="151" mass="17601" checksum="DD49D67B27261CAF" modified="2017-06-07" version="1">MVVRRQVSVKSIKRRSRKAQKAITGRAREFSYRGKTIEELEQMELPELLELFPARVRRSYNREMNHEQQKLFDDLLGDKETLKTHVRDVIILPQFVGKKIELYNGTSYLKFEIKPEMIGHYLGEFAPTRKEVKHSGPGVGATRSSKFLPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1R2</accession>
    <name>A0A1V0N1R2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase DnaG</fullName>
            <ecNumber evidence="9">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaG</name>
        <name evidence="11" type="ORF">FAD_0128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887134.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1R2"/>
    <dbReference type="STRING" id="74969.FAD_0128"/>
    <dbReference type="GeneID" id="16025273"/>
    <dbReference type="GeneID" id="31675640"/>
    <dbReference type="KEGG" id="fai:FAD_0128"/>
    <dbReference type="OrthoDB" id="8643at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050219">
        <property type="entry name" value="DnaG_primase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003108">
        <property type="entry name" value="PRK04031.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30313">
        <property type="entry name" value="DNA PRIMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30313:SF2">
        <property type="entry name" value="DNA PRIMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110455">
        <property type="entry name" value="Toprim domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="172"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="428" mass="47437" checksum="F142C9B5F9F64F25" modified="2017-06-07" version="1">MNVDPNITKYVIKAKIVTDGVVEKPDVVGAIFGQTEGLLGEELDLRDLQKSGKIGRIEVEIDTKKGRTEGFVLIPSGLDQVESSILAAALETIDRIGPCKAKVDIEDVEDVRINKRDKVIQRAEELYKKMGTNGKSLSESIIQSVREEVEKKEILSYGEEHLPAGPAVGTSDSIIVVEGRNDVLNLLRYGIKNTIAVQGTSVPKTVKELSKARTVTLFVDGDHGGELIIKEMLQVADVDFIARAPPGTEVEELTYKQIVKALKYKAPVNQYLESHGMIEELKEFTEKNNKAIADMNVNTTVKEEPQQKKQEKEPKHVETAEVEAPVIEEINDINDPRFVRNKLNELFESKAVEIYDDAGNPIARYPVSDAAELMQSVKNGTTIISGGVISQRFVDIAFSMGVKSIYGMKIGHVTKKPDEIRVVTWEHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1S1</accession>
    <name>A0A1V0N1S1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841591.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1S1"/>
    <dbReference type="STRING" id="74969.FAD_0143"/>
    <dbReference type="GeneID" id="16025288"/>
    <dbReference type="KEGG" id="fai:FAD_0143"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050189">
        <property type="entry name" value="MFS_Efflux_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124:SF3">
        <property type="entry name" value="CHLORAMPHENICOL EFFLUX PUMP RV0191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124">
        <property type="entry name" value="PURINE EFFLUX PUMP PBUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="25"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="403" mass="44445" checksum="80F12F17B1D0B439" modified="2017-06-07" version="1">MQNNIINGAICGYMMRAFDKNQFRILSLVSVTIGLRTLGLFMVLPIFTLYGEKFTGSYLLIGTALGAYGITMALFQTSLGRLSDRYGRKLIISIGIATFIIGNLICADPINIYGLILGRLVEGAGAVSSAGIALVHESVPVNRRNISDAIIGVAIGLSFMLGVIVGPLLATIFNYSSIFVIAAIIGAISFIPLWKVKETKKEKMFKIKAHIDSKLAVISIISFFIYFYMIVFYLYLPVFSLKYFPVSRFYEFLIPVVFIAGIIGLAIARPADKNKTVLFSLVSLIVLLISVPLFFLNTHVTDVTYFALSVAGFYSGYIISETVFPTLITRLAPKNSYGGNLGFYTSMQHAGVFFGAVVGGLLIIKVNHDIPIMIIIFTLFVFSIVLLYFITQFREIYLSNNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Y2</accession>
    <name>A0A1V0N1Y2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0237</name>
        <name evidence="2" type="ORF">HLB00_02175</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000064">
        <property type="protein sequence ID" value="NOL59640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141425.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Y2"/>
    <dbReference type="GeneID" id="84218729"/>
    <dbReference type="KEGG" id="fai:FAD_0237"/>
    <dbReference type="OrthoDB" id="17710at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24286" checksum="C138FF163E1DEAA4" modified="2017-06-07" version="1">MTRVGIYTHDFKFYHDIIKELKRWNLPFFSIPDLYSIPGDINVILSSEQDPFTLPGQIKAVTATEGIRRSLPVLLNKSQFTRVIIGIDPGPRPGIAVMADNVLMEAWECPTICGVKDDVLDVVKNYSYRYIMIKIGNGDRPNRDIIIKQLKNIAPMVIVNEENTSTPHKIHDNALSAARISLIDDRYDTSRTPVKFSRKNIYDKEFITLHSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Y4</accession>
    <name>A0A1V0N1Y4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Small ribosomal subunit protein eS4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps4e</name>
        <name evidence="10" type="ORF">FAD_0171</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Y4"/>
    <dbReference type="STRING" id="74969.FAD_0171"/>
    <dbReference type="KEGG" id="fai:FAD_0171"/>
    <dbReference type="OrthoDB" id="372073at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003312">
        <property type="entry name" value="PRK04313.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="240" mass="27194" checksum="F0E79CA8EDB3F003" modified="2017-06-07" version="1">MIMKTKIMMASRKLKIPRKTNFWSVTPTPATHSKEDSIPMLIALRDYLKLGDKEREITRILNNNMVKVDGRIVKDRRFPVGFMDVLSIDTLENDYIIVYDRKGKLVIRQNAPGNKGLKLFKVVKKTIIGTGKIQLGFHDGKTIVTDRKDINTSDVLLMKIPDLEIENVLKIAEGDKVFITGGSHVGELATIKSIEVKKSSVKNMVYLNEGFSTIKDYMFVVGTPKYTFKTPEIEVISNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N209</accession>
    <name>A0A1V0N209_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N209"/>
    <dbReference type="STRING" id="74969.FAD_0268"/>
    <dbReference type="KEGG" id="fai:FAD_0268"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="325" mass="36841" checksum="977EAA59909AC511" modified="2017-06-07" version="1">MINTIDDLWYLKNILDRGDQIITSVFRRQEQNADLNRSKATERKKINIKLNVEKIDFLPYTDNLKILGEILEGENSGSHQSVMIGVDDEITIIKTLDSGERAFLDEAVENYYKNSIVFVSLDDESCIIALMKSYGIQEIADISSKKSGKDYGSNGEDPGYYKEIIASIKNIKNPASIIILGPGFEHTKLYKKIMDDPFFNGIALHDFPETDNGKRGIYEFMADKKSGDILKGARLAADEKLIENFLINLNKTGLSIYGYDELVKYSRMNMVEDILISESKFKDPETRKLLNEATGINIHVISDYTESGDIIKQFGGYCGILRYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N211</accession>
    <name>A0A1V0N211_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal actin-like protein group A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">ParM/StbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0238</name>
        <name evidence="4" type="ORF">HLB00_07635</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000282">
        <property type="protein sequence ID" value="NOL60699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887246.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N211"/>
    <dbReference type="STRING" id="74969.FAD_0238"/>
    <dbReference type="GeneID" id="16025391"/>
    <dbReference type="GeneID" id="31675747"/>
    <dbReference type="KEGG" id="fai:FAD_0238"/>
    <dbReference type="OrthoDB" id="55553at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040607">
        <property type="entry name" value="ALP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049067">
        <property type="entry name" value="MreB-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17989">
        <property type="entry name" value="ALP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21522">
        <property type="entry name" value="MreB-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin-like protein N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Actin homologue MreB-like C-terminal" evidence="2">
        <location>
            <begin position="173"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="326" mass="34731" checksum="1E15119E69C45A58" modified="2017-06-07" version="1">MVILGVDLGYGDTKLVTEGNKKAKFPSRWTPAESRNWGIGGNIPVISVNDGESFIFGEDATGTNLREPQGDGRLTDPNAIQLLAGALWTSGIGHEGEKTDVTLSSGVQLGSFDREVVEAAKLLEGKTLKIKSAQGTEQDFKISKLVMRPQGVGAAIYALNHGILKTQYGNGVIIDIGFKTTDVLTINLKNMEPIIEDSFSIQAGIGDVVSGMSKVIGKQTGFVVPPDVARDAIGEKIVFKQNEIGGPDVSGPLLDQLALRIVNEVEETLREDMNRITALLPVGGGSILIGNKLDTIAPGHMIKVPPEDMQFANVLGYKIAASEQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N218</accession>
    <name>A0A1V0N218_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit Rpo5</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpo5</name>
        <name evidence="2" type="synonym">rpoH</name>
        <name evidence="4" type="ORF">FAD_0208</name>
        <name evidence="5" type="ORF">HLB00_06635</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000234">
        <property type="protein sequence ID" value="NOL60506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141404.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N218"/>
    <dbReference type="STRING" id="74969.FAD_0208"/>
    <dbReference type="GeneID" id="84218698"/>
    <dbReference type="KEGG" id="fai:FAD_0208"/>
    <dbReference type="OrthoDB" id="30537at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="86" mass="9836" checksum="15FDD910B0D810EF" modified="2017-06-07" version="1">MSKFNVLEHEIVPEHHLVPVEDEESVLTKLNVTKENLPKISINDPTIKALEEIHGTLEPGRVVKIIRKSPTAGYYEYYRVIVKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N262</accession>
    <name>A0A1V0N262_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF424 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0259</name>
        <name evidence="2" type="ORF">HLB00_03140</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000099">
        <property type="protein sequence ID" value="NOL59828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N262"/>
    <dbReference type="STRING" id="74969.FAD_0259"/>
    <dbReference type="KEGG" id="fai:FAD_0259"/>
    <dbReference type="OrthoDB" id="18015at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1860.10">
        <property type="entry name" value="uncharacterized conserved protein from methanopyrus kandleri domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="95" mass="10445" checksum="B34B0CC040C1E09B" modified="2017-06-07" version="1">MKILNINGEVMLAAADSELINKDLREGKLHLKIKPEFYGEMKVSEETFLSSLDICTIANLVGEHVVNAAIDANYIEKDNIIKIAGVPHAQLAKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N264</accession>
    <name>A0A1V0N264_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps11</name>
        <name evidence="9" type="ORF">FAD_0262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141431.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N264"/>
    <dbReference type="STRING" id="74969.FAD_0262"/>
    <dbReference type="GeneID" id="31675771"/>
    <dbReference type="KEGG" id="fai:FAD_0262"/>
    <dbReference type="OrthoDB" id="12054at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044391">
        <property type="term" value="C:ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000018">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019961">
        <property type="entry name" value="Ribosomal_uS11_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03628">
        <property type="entry name" value="arch_S11P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="127" mass="13753" checksum="286707AFC0115C45" modified="2017-06-07" version="1">MNKIGIAHIYASQNNTIILITDQTGSETIAKSTGGMVVKNDREESSPYAAMKASDIITEKLREKEITDLIIRVRAPGGSRSRIPGPGAQSAIRALSRAGFKILRIEEVTPTPHDGTKKKGGKRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N272</accession>
    <name>A0A1V0N272_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141442.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N272"/>
    <dbReference type="STRING" id="74969.FAD_0273"/>
    <dbReference type="GeneID" id="84218771"/>
    <dbReference type="KEGG" id="fai:FAD_0273"/>
    <dbReference type="OrthoDB" id="17656at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002272">
        <property type="entry name" value="PRK01207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="342" mass="39870" checksum="A78B2902097F7A35" modified="2017-06-07" version="1">MGKYLISQEIGSFRKPKYLSTVFHKIYGTEEYYKLSEKATEETIDLFRHAGLDNIGVGGEMFRWEMYEHQANRVDGIKFYGPVRSFDNRYYKKGSIVEDISIKESFHSDELEYLLSKGYDNIKIPVTGPYTMMDWSFNEHYSDRYETAMAFATLLNSEMKTLKKLWDSKYPGRKLEIQLDEPATTTHPDEMNIVVDSLNKSVEGIDNCEFTIHVCYSTDYRLLYDVMNDIKIDGLNLEFANRDKLEPGTSDAARPGYEELKYFQQLNTKKKFIGLGVTDVHIDYIEPVRLIKDRINYTLNIMPPELVRVNPDCGLRTRSIETGYEKLKNMDTARNEILKEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N298</accession>
    <name>A0A1V0N298_9ARCH</name>
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        <submittedName>
            <fullName evidence="5">Zinc-binding alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141461.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N298"/>
    <dbReference type="STRING" id="74969.FAD_0294"/>
    <dbReference type="GeneID" id="84218794"/>
    <dbReference type="KEGG" id="fai:FAD_0294"/>
    <dbReference type="OrthoDB" id="8709at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:adenyl nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043168">
        <property type="term" value="F:anion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="10"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="317" mass="35166" checksum="44E8F4E4E928191A" modified="2017-06-07" version="1">MKAIEFAKPGIENVNIVDKDLSGEGIKVKIVKAGLNPLDYNLIAGNIVYNVYPMPHIPGSEVMGIAMEDGKRIRKGDRVIVYNRVFDNGCDMCYSGNEHLCYNGGIWGVITNGGYSEYIKIGEQNLFRVPESIDDNTAVSIGIGALTSYRSLKRARAGINDKILVYGAGNTGIFTVQIARQMGMDVYVYSRNRELESLGIKVLDSVPDDFKADIIVNPLGGKLFGDSIKHLKRRGKIVTYGVLTGRNADLDIANVYTNELEIIGSTGGTRKDLTELMQILEKSNFRLPVYKEYSLWDIKDALHAFKDRVNGRIVFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2F7</accession>
    <name>A0A1V0N2F7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0366</name>
        <name evidence="3" type="ORF">HLB00_03485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000112">
        <property type="protein sequence ID" value="NOL59896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887385.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2F7"/>
    <dbReference type="STRING" id="74969.FAD_0366"/>
    <dbReference type="GeneID" id="16025531"/>
    <dbReference type="KEGG" id="fai:FAD_0366"/>
    <dbReference type="OrthoDB" id="384383at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="79" mass="9030" checksum="4323BC9A0F768595" modified="2017-06-07" version="1">MSEDNNGNRNSIKPVRSKIALKNVKETLPDKGKESKIKGQKENTISETNTRIDPFGINRQKKVIKKDNEKKDSTNYFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2F9</accession>
    <name>A0A1V0N2F9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141531.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2F9"/>
    <dbReference type="STRING" id="74969.FAD_0355"/>
    <dbReference type="GeneID" id="84218853"/>
    <dbReference type="KEGG" id="fai:FAD_0355"/>
    <dbReference type="OrthoDB" id="56958at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="188" mass="22152" checksum="E245CC6A855AEEE4" modified="2017-06-07" version="1">MLFKKNVQKTEKIEEKTKTVLKIKTVDDIPVIKEMRKKIGNGERKEAIIYGYTNLKNDYTRFYGCQKYSSNRDFILSEISHFDIVPDRTEFSTDNFTIKNLIENSIYNKEETDATPDNAGKTDSVEKNTRFFAIKKIALFYFNYYEIARFGDYNWDALDEKEIIDPVKDAYNYMDIMKLFYGGEPHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2G1</accession>
    <name>A0A1V0N2G1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141539.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2G1"/>
    <dbReference type="STRING" id="74969.FAD_0363"/>
    <dbReference type="GeneID" id="84218861"/>
    <dbReference type="KEGG" id="fai:FAD_0363"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="192"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="372" mass="41850" checksum="7981D9D509EE968B" modified="2017-06-07" version="1">MKVAVVGWELPPAFSGGLGIHTSNIFSIIGKIVPTEIYLPDMGYSFPYYPFSIITVKITKGVAGGSYSQVTNFIDAVEDYNRNVIENFRPDGVSVIHCHDWITFRAGIEIKEKFGIPLVVTFHSTEYDRSAYFNPQGNIMKIEKEGAEKADAIITVSNSTKRVLVEKYGIDADKITTVYNGVKSSAYTQGVSYKRERMLLYFGRVTSQKGPKFFMEMADKVNQYEKNVKFVMAGTGDMIGEMESYAVNHGFREKVFFPGFVDFHKAIEYYKRSGVFVIPAVSEPFGITVLESMVSGSPVIMSKTTGVGEALNNVLKVDYWDTDVMSSYAISILNHKSLRETLSLYGKYEGMSFTWEKSAIKTMEVYRSIWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2I0</accession>
    <name>A0A1V0N2I0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Transcription initiation factor IIB</fullName>
            <shortName evidence="9">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tfb</name>
        <name evidence="12" type="ORF">FAD_0420</name>
        <name evidence="13" type="ORF">HLB00_04880</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000166">
        <property type="protein sequence ID" value="NOL60170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887476.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2I0"/>
    <dbReference type="STRING" id="74969.FAD_0420"/>
    <dbReference type="GeneID" id="16025622"/>
    <dbReference type="KEGG" id="fai:FAD_0420"/>
    <dbReference type="OrthoDB" id="7429at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20549">
        <property type="entry name" value="CYCLIN_TFIIB_archaea_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000023">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001658">
        <property type="entry name" value="PRK00423.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="11">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="9">
        <location>
            <begin position="122"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="9">
        <location>
            <begin position="216"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL60170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="305" mass="34233" checksum="76713A688578546B" modified="2017-06-07" version="1">MKTDEVKNCPECGSIHLVKDYDRGELTCYDCGIVIEDSLIDQGPEWRAFDSEQDGKRSRTGSPMSFLSHDKGLATEISWSNKDYYGKRIPHKNRSQIYRVRKWHQRIRVSNAAERNLALALQVLNEDGAKLGIPKDIKESAALIYRKAVEKNLIRGRSIESIVCASIYASCRMINIPRTLDEISKVSEVNKKKIGKAYRHLAKELALNLQPTTPYSYVSQFCNKLDLDKQVIMDSEHIIRLAGESGLSTGKGPTGIAAAAIYIAAMKNGKQRTQKDVARVSGVTEVTIRNRYKEISKKLGIDDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2I5</accession>
    <name>A0A1V0N2I5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase mutator family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0394</name>
        <name evidence="5" type="ORF">FAD_0934</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887601.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2I5"/>
    <dbReference type="STRING" id="74969.FAD_0394"/>
    <dbReference type="GeneID" id="16025750"/>
    <dbReference type="GeneID" id="31676439"/>
    <dbReference type="KEGG" id="fai:FAD_0394"/>
    <dbReference type="KEGG" id="fai:FAD_0934"/>
    <dbReference type="OrthoDB" id="56934at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033543">
        <property type="entry name" value="transpos_IS256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217:SF8">
        <property type="entry name" value="MUTATOR FAMILY TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="386" mass="45555" checksum="925B34D2F8B4DC7E" modified="2017-06-07" version="1">MENTDINISALENVDIDRILKEAIKEKIEKLMETELNAYLEENPGIKNGKYKRDLKTKYGEIKQLNIPRDRDSNFHTKVIEPYNRSIGIEDLIVSMYSNGISTRRIAGIMEDILGNKYSKSTISRITDLTIEEVYKFVNRPLDKRYIAIFLDGLFFYLRRGNVDKEPVIFALGIKETGEYEVLGFYLTVKESHNSYKEVLEDLYSRGLKEPLLIVADGIKNLDEEVMEIYPRSEFQLCTIHYTRGLKSNVRERDIEEISIDANKMFKCDSKEEGIIKFNDFKYKWESKYPKVIYNTEKNLGKLLRFYNYPSSIWRSLKSTNAIERLNGEVRRRVKTISSFPDEDSAMKVFYYKSIEYNSKHAFRKMNGYYKCKDEIKEMFNKRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2L7</accession>
    <name>A0A1V0N2L7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Small ribosomal subunit protein eS8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps8e</name>
        <name evidence="8" type="ORF">FAD_0412</name>
        <name evidence="9" type="ORF">HLB00_05005</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887444.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2L7"/>
    <dbReference type="STRING" id="74969.FAD_0412"/>
    <dbReference type="GeneID" id="16025590"/>
    <dbReference type="KEGG" id="fai:FAD_0412"/>
    <dbReference type="OrthoDB" id="372305at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11382">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00029">
        <property type="entry name" value="Ribosomal_eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020919">
        <property type="entry name" value="Ribosomal_protein_eS8_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL60194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="126" mass="14449" checksum="D2D1F1F85BCA746F" modified="2017-06-07" version="1">MTIYQGKSTKKFTGGKLRREHSKRRYELGREPSFTRIGETERRSLRTMGGNRKLLLLKEQFANIYNPEDKTTKKLKILTVKENNADPHYVQRNIMNKGTIISTEEGNARITSRPGQSGIINAVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2L8</accession>
    <name>A0A1V0N2L8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0468</name>
        <name evidence="9" type="ORF">HLB00_04225</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000145">
        <property type="protein sequence ID" value="NOL60040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887523.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2L8"/>
    <dbReference type="STRING" id="74969.FAD_0468"/>
    <dbReference type="GeneID" id="16025672"/>
    <dbReference type="GeneID" id="31675977"/>
    <dbReference type="KEGG" id="fai:FAD_0468"/>
    <dbReference type="OrthoDB" id="27121at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL60040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="449" mass="49575" checksum="BCA9F3D48252E6EC" modified="2017-06-07" version="1">MDIEKSGGHNSEFVYNEFEPVPEEMRKNNSSELFTLWFASNMTIGDFAIGFIPVLLGLSLGMSLFSMLLGSVMGSILVAFMSRTGTLTGLPQMVLGRRAFGKNFGIFMTVLQWINTLGWLTVNLILASFAFSLAFHVPYYEISIILMGIIIFLISNSGRKSISYFEKAMSVILGILFTIIILNAGLHINDIYAYKPSSFGFGVAFGITLATSFSYLMSWGPYAADYSRYNKTKNAFIYTFSGGLIATFWAEIAGVFVAIMSLDPSGNPASDLNHVLGPYGIIGLIAIFLGGIAADALNLYSNSISLKSTGLKIRRIYSVIFGIVIAIALAVALYTKFYSFYEDFLFLLDYWITPWLGIMLADFFIVNRNEKFNIKTIPGLNISGISAYFIALIASVPFMDPGIIFEGPISKLYLGGVDISYYVSFLLALVLYPVITKVINRNNIQSHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2M8</accession>
    <name>A0A1V0N2M8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replication factor C large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887533.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2M8"/>
    <dbReference type="STRING" id="74969.FAD_0478"/>
    <dbReference type="GeneID" id="16025682"/>
    <dbReference type="KEGG" id="fai:FAD_0478"/>
    <dbReference type="OrthoDB" id="8658at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003229">
        <property type="entry name" value="PRK04195.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="419" mass="48259" checksum="F67B405F7A20818D" modified="2017-06-07" version="1">MSLADDYRPSDLNSLLLSNEARQAMISWIDSWMNHSEVKNSLILWGQQGIGKTSAAYALASYAGLPVVEMNASEQRNKESMKKIALMASQYRNLFDDDARMPDKLILIDEADNIFESRSRSSGGDTGGMSELLEIIKNTKNPVIITMNDYYSFKSKNNAREIVSRSVEIEMTPYKRKNEVNYKIFTSGVHSVLKNIAIKENIHINDHEIDGIIRSNEPDIRAMINDLYLYSSRENDYGENSRDKSESIYYLTSDTFRGNDYDTIISALYKMDEDTDFYMKWIDENIPYEYTDPVDLKNTYDLISIADIYYGNRFKNFSLASYGMEITAGISVKAKNRNDHYVKYNFPSFIKKMAMRKKNFELYNTINFAGRMGAISHTSTATISGNMWFYHIMKQKDRKLYSFLSTLLGITEKQTHSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2T4</accession>
    <name>A0A1V0N2T4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase</fullName>
            <ecNumber evidence="7">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">polB1</name>
        <name evidence="10" type="ORF">FAD_0471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141623.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2T4"/>
    <dbReference type="STRING" id="74969.FAD_0471"/>
    <dbReference type="GeneID" id="31675980"/>
    <dbReference type="KEGG" id="fai:FAD_0471"/>
    <dbReference type="OrthoDB" id="323192at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00145">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="9">
        <location>
            <begin position="193"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="8">
        <location>
            <begin position="344"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="777" mass="89079" checksum="06352FB81FAC8437" modified="2017-06-07" version="1">MNVKMRIVAASYRQSDVTVELYGRTEDNKSITALYYGFKPYFDYVEPDEKCITEIKNNPEFIKMEDKKLFLEGKDVNVKRIYIKSPWKVPELRKICQCQALAADIPFHHRFIYDFDLGSTVEIEGEPAEGEKGNYTTDLVIKINTVKKTDDFNPQLKIFSFDIENSISTREIFVIGYSVFFNGEITEGALTGTEPEILEDFNKLVQREDPDIITGYNIDGYDMPLLEERMKFNKVRFSIGRDYISPRRIMDQYWRLHGRVIDDTWWEVRKVLHPKHETLNYVSNMLLNEGKEDVNRLDIENEWKNRRDDVIKYCIKDARLALLIYRKIRILDRNLYLSTVSMLPLDDVTNGGTSTYVDSLLIRRADRENIGVPMSSSKFSNDTYAGGYVHTMDPGLYDMIVVLDFKSMYPSMIIKYNICFTTLSPEGTIQAPNGARFLDPGVKKGIIPDLLEQLMKNRDEVKKQMKEDKSNHDYLDGLQAAIKVLMNTFYGVLGTSFYRFTNREISSAITAYARNTITSIIADLDKSGNKVIYGDTDSIFIESGKKTLDEAIEYGNRLSSDISRKENLVLEFEKIMDPLFSHGAKKRYAGKIVYPPSSAGEILVRGYETRRTDSFDLQSEALSTVFDLILSRDVEGAKQYAEDLVKEVATGKIDTAKLVISRSVKNFSTYKNAGSMANVNAAKKLIDAGETFIPGMKVSWIVTDAGKTPQAVEPFIDGRKFTHTPDYVYYSKRLQETLNRVLESLDKEIAVFKNPQSKITDAFEEKPKKRDIEDFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2T8</accession>
    <name>A0A1V0N2T8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887557.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2T8"/>
    <dbReference type="STRING" id="74969.FAD_0501"/>
    <dbReference type="GeneID" id="16025704"/>
    <dbReference type="KEGG" id="fai:FAD_0501"/>
    <dbReference type="OrthoDB" id="36110at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02042">
        <property type="entry name" value="ParAB_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050678">
        <property type="entry name" value="DNA_Partitioning_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13696">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13696:SF52">
        <property type="entry name" value="PARA FAMILY PROTEIN CT_582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="285" mass="32141" checksum="B77CF83E09C321D0" modified="2017-06-07" version="1">MTHIISIINLKGGVGKTQTSIAVSEFLATNYAKKVLIIDLDPQTNATVSLMDENLWLEHDKKGNTIFQLFSDKVYNTELFNVESSIVKNVSNIGSGIKNLDLLPSSLRLIDIQDKLPLVSNSGYFVRTPITILKEAVSSIIKNYDYVIIDCPPNLGLITLSGIFISDYYLIPTIPDILSTYGIPQILTRINAFKEDAGINIKPLGILISMFRANNRLHKSIIDSLKYRERRGDYPRIFDTYIPLSIKISEAAEFQSSVKTLGQKYGYDLYNSYNRLVEEVIKYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2T9</accession>
    <name>A0A1V0N2T9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141636.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2T9"/>
    <dbReference type="STRING" id="74969.FAD_0497"/>
    <dbReference type="GeneID" id="31676006"/>
    <dbReference type="KEGG" id="fai:FAD_0497"/>
    <dbReference type="OrthoDB" id="34376at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052714">
        <property type="entry name" value="MFS_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23531">
        <property type="entry name" value="QUINOLENE RESISTANCE PROTEIN NORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23531:SF1">
        <property type="entry name" value="QUINOLENE RESISTANCE PROTEIN NORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="402" mass="45027" checksum="D6BFCF50439A2CB3" modified="2017-06-07" version="1">MEKKNVSFIYLAITLIIMTFSMRATNNMIITTVPLLAKIDLGFSSFFVGIISAVIYLFTFTVTFYVNPRINARLRRQLFIGANFAILFSLIAYYFTNGIAIWGISALAGLAYGIMMPNLITSSTLLKDQKERERLISLYSVGLSLSLILGPTIEDYILTFVSYRDVFLLFIPIVIAGVIVSTMIKFPHTKNETRANVMKNDGLRASLLTITTYNIPFAALSIFLTLYAIARFHVSGAVAYSPYIYFFSISFLTRILLTIHPLKHIKLPLLFSIMITGFALIMFPFLTTFTSFLLLMMLLGIPHGSIFPMSTIMIARGTSVEQRSAANSYFMAYNNILFMVIPLAFGYIVKFIGYEYSFLILIAPVILSAVALFKIYGSNTTIFISNLKKVPPNAISGKKNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2V0</accession>
    <name>A0A1V0N2V0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">3-hydroxybutyryl-CoA dehydrogenase/3-hydroxybutyryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FAD_0511</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887569.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2V0"/>
    <dbReference type="STRING" id="74969.FAD_0511"/>
    <dbReference type="GeneID" id="16025715"/>
    <dbReference type="GeneID" id="31676019"/>
    <dbReference type="KEGG" id="fai:FAD_0511"/>
    <dbReference type="OrthoDB" id="39812at2157"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23309">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23309:SF49">
        <property type="entry name" value="PEROXISOMAL BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="185"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="302"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD84425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="642" mass="71245" checksum="822ABA95CA5DED25" modified="2017-06-07" version="1">MIKQVAVIGAGVMGHSIAEVFALNGYKVNLEDFYPEVIEKAKVGINGSLDKLIASGKINDAAKKAALDNIKFFNNIGEAVKNVDLSIEVVPEIYNIKVKVLKEIAENTDKIIASNTSNIRITEMGEEIKNPERLVGMHFFNPPILMKLVEVIKGDKTSMEYVEEIYELAGKIGKKPIKVLKDEAGFVVNRISAPEMLLLCNAYGNKIDRPEAIDKYFKSQGLPMGPYQLFDYVGLDTVVDSLQYYGKELSPDYGKCHAFDSFIEAKHLGLKTGSGIYKWENGKAIIPDANESEKISLMDMFALEINEATKLIEDGVAVPDDIEIGVKYGLNRPFGPITVANGLSNDEVLETLNNLYKQYKIEVFKPSKTIESHKMKESFNKKPVEVKKEEKSGILDYSKDGKVGVITIKNGKNNLMSFELLKALDKQLDAIEEANDVNVVVIKGNERAFSAGADLSQFISNPYMFMKISNTGESIFDRITRMNKIFIAQLRGYVLGGGFELSLACDIRTSLPDSVIGFPETSLGLIPGYGGSQRLPNLIGISRAMDMILTCERISGEKAYEYGIITRLFKEELEENTMKLAKDLSEKISPASVYVAKRLIYNTATINLDEEALSMGMLYAGNDMKEGVKAFLEKRKPDYKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2V2</accession>
    <name>A0A1V0N2V2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase Hel308</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA 3'-5' helicase Hel308</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hel308</name>
        <name evidence="14" type="ORF">FAD_0578</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the helicase family. Hel308 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887635.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2V2"/>
    <dbReference type="STRING" id="74969.FAD_0578"/>
    <dbReference type="GeneID" id="16025785"/>
    <dbReference type="GeneID" id="31676082"/>
    <dbReference type="KEGG" id="fai:FAD_0578"/>
    <dbReference type="OrthoDB" id="371946at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00442">
        <property type="entry name" value="Helicase_Hel308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048772">
        <property type="entry name" value="Hel308-like_dom4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022965">
        <property type="entry name" value="Helicase_Hel308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002251">
        <property type="entry name" value="PRK01172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF10">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE HEL308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21280">
        <property type="entry name" value="Helicase_dom4_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="30"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="222"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="681" mass="76905" checksum="91B69FD9F91DB8BF" modified="2017-06-07" version="1">MKLSEITPSEFLKVTDNNDFTLYEHQEEAVAKLRENKNVIVSVPTASGKTLIGYISIYDTYLKGKKSMYIVPLRSLAMEKFSELLSLRNLGVKVTMSIGDYDVPPSFVKNYDVIIATSERADSMLHRDPDILNYFGLVIIDEIHMISDPSRGPRLETVISSLLYLNPEILLLGLSATVSNIQEIAEWMNAETVVSNFRAVPLETGIIFKGNLITDGEKKHLGRDDEVSLIKESIESGGQALVFRNSRRNAEKYAQSMVNFFDFQNDFEKLEIPPDLFNEAQANMVAHGVMFHHAGLSNDQRTMIEKLFKQGYIKILTATPTLAAGVNLPARTVIIRDITRFSDGYSKPISGIEIQQMIGRAGRPKYDKKGYGYIYAASPGMLRVAEGYLTGELEPVISRMDSNSLIRFNVLALISSGIATDLKGIQDFYGKTLLAAQNDIDGYELAFESALYFLKDNDFITEENDIYSATKFGRLTSDLYIDPVSSLILKKCLDLEFSEELYLYYISKTPDMLTFNYRASDYEYLEEFLDRHNISDFSEESMGAAKTAIILNEWINEVPINTIAETFGIGPGDIQAKASSADWISYSLYRLGSMFDKENENNLLHLNIRIKEGVKEEIIRIIEIPQVGRVRGRRLYNNGFKSIDDIANARVEDISRIFGFSTKLAKDIIENAGKLNNRYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2W4</accession>
    <name>A0A1V0N2W4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiL</name>
        <name evidence="4" type="ORF">FAD_0531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>thiamine phosphate + ATP = thiamine diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887588.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2W4"/>
    <dbReference type="STRING" id="74969.FAD_0531"/>
    <dbReference type="GeneID" id="16025737"/>
    <dbReference type="GeneID" id="31676038"/>
    <dbReference type="KEGG" id="fai:FAD_0531"/>
    <dbReference type="OrthoDB" id="45909at2157"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004353">
        <property type="entry name" value="PRK05731.2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="THIAMINE-MONOPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270:SF3">
        <property type="entry name" value="THIAMINE-MONOPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="3">
        <location>
            <begin position="148"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="322" mass="35684" checksum="A6323D0B8B351662" modified="2017-06-07" version="1">MKLKDLGERKIIQTLEDGSKNLDNRDDCAIIGFGNYYALLSTDLITRETHLPEGAEPFLAGKFFAAINLSDIAAMAGIPSGFLISLSVSPEYDISYLEEFYRGVRHELDKFNVSIIGGDTKEGSDFTAAGTIIGKQVPELIRRRSEIKPGQFLMVTNSLGSSAAGYIYYMYGINRELGIRKMLDVEPRINEAIKISASGAKFMMDLSDGVYASIHQISTDFGVGFKLYGDKIPFDRDVEKAASISNFSVSDIALSFGGDYELMFTVEKNSLEEFMAAMSHENIEVHCIGETYNGDNVIYDGRAWVPVINKGYEHFNSMPLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Y2</accession>
    <name>A0A1V0N2Y2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CDP-alcohol phosphatidyltransferase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0601</name>
        <name evidence="5" type="ORF">HLB00_10100</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000443">
        <property type="protein sequence ID" value="NOL61169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887658.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Y2"/>
    <dbReference type="STRING" id="74969.FAD_0601"/>
    <dbReference type="GeneID" id="16025808"/>
    <dbReference type="KEGG" id="fai:FAD_0601"/>
    <dbReference type="OrthoDB" id="9904at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL61169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="201" mass="22759" checksum="24F3D3D7271B6311" modified="2017-06-07" version="1">MVLDSYRKKADRFLDPITKKFSGINPNTISILSLVFAALAGIFYYLSHYFLLLAFIFIIFSALFDALDGKIARLKNISSKKGDMLDHVFDRYSDMFIILGMTFSIYGNVYFGLFAILGILLTSYMGTQSQALGLKRNYSGIAGRADRLILIIIFSLIQFFVSSHFSIYSIDIYATGILLIWFGLAGNITAITRFFDMYKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Y3</accession>
    <name>A0A1V0N2Y3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome partition protein Smc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887610.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Y3"/>
    <dbReference type="STRING" id="74969.FAD_0552"/>
    <dbReference type="GeneID" id="16025760"/>
    <dbReference type="GeneID" id="31676058"/>
    <dbReference type="KEGG" id="fai:FAD_0552"/>
    <dbReference type="OrthoDB" id="9143at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02169">
        <property type="entry name" value="SMC_prok_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="7">
        <location>
            <begin position="511"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="228"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="653"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="797"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1156" mass="132585" checksum="A1D69A9EB165725B" modified="2017-06-07" version="1">MIVDSIEMENFKSYGDKQSIKINKGFTVIIGPNGSGKSNIGDSMLFVLGIRANKTVRVDKLEDFIHKTDPPKKHCYVVLNVISNENNRYSIKRELVYNHGEYKSNYYINDKRASRTDVLKLIDSFHIYLDAYSFVLQGDINNLVKMTGTEKRKLFESIAGIESYKERIESAQNDINGLNENLNSMDAVLLEIKSMLDTLEVDRENALKYNKLNKEVNELKFFLKVKDRDRINQELAMYNGNIEKSQSDIDNLENENKNLSIQRDEAINRIKEIEDKLDAMGGQEVKGIRKRIEELNIGIAELKTKIGSTGESKTNSEARLKTSREAYNFNREQLENKLKEKKNYESYLKGTENSIAKINRELEKFRQENYENSKLTREINDRLAAIDVEMQQANDQIINDYDIRTIEQELSGFSRENTMNEEKIKEESIKVKDLKWKIDNLKKNIKEYSEEINEVNKKFLTVRNKLNELVTMKSNNDVEIRNKEKELRGLNYRGTASPALREINSMMETESGIHGPLGKLIEYEDKYANAVIVAAGGRLNSIVVDNDSVAQMCIQAIKAKKLGRLTFIPLNKIATSPDRQKAAELINSGNAIDFVRNLITCDPAFEKAIKYAFGDTVLMDTLENARKHMTGVRIVTLDGDVLDPSGAMTGGSIKNDEILANRITKAIAELEEQNEILKSEISFKEKENSEISSKLADLTRKRDISTSNINNYETQLQESENSIEAAKTRIEEIKLKIKDAEDRKSNFEFKKNEVKMQLFTLDKERKELFKKLKELAPENVEIEKQMEEELGNEMKSRENYSSKLAQIETEFKHFTEKSQELEEKITGLENEITKFTGMVAEFKNKVEAMEKELEENRAKENEIDSRSRELYTEKNQVSTARDKLFENIRKNDDLISNKKAIIAGLKTKIENLAFQLETINYEIENTGMEYIEFNMSISEVKQKIDENSREIEKLGAVNMKAIEQYDMELNKYNSTEEKYKTLLSEKNDLIDLQNQIIEDEKRIFLELFDTINSQFQKIYARLSEGGEANLEITSRDDPLNSEVYIKVKPRGKHMIKIDALSGGEKSVAVLALILSFQIKNPSPIYYLDEVDMFLDGHNAEHVGELFMENSKTSQVVMVSLKGAVTKFADNLIAVTTDKHGNTKIIQKRIGEGIGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Y8</accession>
    <name>A0A1V0N2Y8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <shortName evidence="10">GAPDH</shortName>
            <ecNumber evidence="10 12">1.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gap</name>
        <name evidence="15" type="ORF">FAD_0549</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10 12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10 12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10 12">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="10 12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Y8"/>
    <dbReference type="STRING" id="74969.FAD_0549"/>
    <dbReference type="KEGG" id="fai:FAD_0549"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18127">
        <property type="entry name" value="GAPDH_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02278">
        <property type="entry name" value="GAPDH_II_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00559">
        <property type="entry name" value="G3P_dehdrog_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006436">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01546">
        <property type="entry name" value="GAPDH-II_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003251">
        <property type="entry name" value="PRK04207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="4 10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="14">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10 11">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD84461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="344" mass="38343" checksum="895D6C46BA4241F9" modified="2017-06-07" version="1">MQHYLIPMIGVAINGYGTIGRRVAYGVSIQDDMYVTGIVKNSPDYVTKLASRDFNIYTPDMDKKREFEAHGIRVKGTLDDLLSESDIVVDGTPEGNGEKNLKLYRQYGIKAVLEGGEKSTVVESSFNSYSNYSSSLNKNYVRVVSCNTTALARSVSPLKEKFGVQEVNATIMRRATDPNDNKKGPINAIEPSMSYPSHHAEDLKTVMDGINVETSAVKVPTTLMHVHVINLELKSEPGIDEVISELSKKRRLILINDKEGVNSTAQVMDYARELSRNRSDLYEIAIWKGSINIYKNKVHYIQAVHQESDVIPENIDAIRAMFGMDPDLSRDKTDASLGIKGVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N302</accession>
    <name>A0A1V0N302_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS</fullName>
            <shortName evidence="6">tRNA(Ile2)-agm2C synthetase</shortName>
            <ecNumber evidence="6">6.3.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile2) agmatidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">tiaS</name>
        <name evidence="10" type="ORF">FAD_0572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + agmatine + ATP + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43608"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10626"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83545"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TiaS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141696.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N302"/>
    <dbReference type="STRING" id="74969.FAD_0572"/>
    <dbReference type="GeneID" id="31676076"/>
    <dbReference type="KEGG" id="fai:FAD_0572"/>
    <dbReference type="OrthoDB" id="39189at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04482">
        <property type="entry name" value="RPA2_OBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01892">
        <property type="entry name" value="tRNA_Ile2_agm2C_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053870">
        <property type="entry name" value="TiaS-like_TCKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013696">
        <property type="entry name" value="TiaS_FLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024913">
        <property type="entry name" value="tRNA_Ile2__agm2C_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055394">
        <property type="entry name" value="Zn_ribbon_TiaS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40705:SF2">
        <property type="entry name" value="DUF1743 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40705">
        <property type="entry name" value="TRNA(ILE2) 2-AGMATINYLCYTIDINE SYNTHETASE TIAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08489">
        <property type="entry name" value="TiaS_FLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22641">
        <property type="entry name" value="TiaS_TCKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23783">
        <property type="entry name" value="Zn_ribbon_TiaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TiaS-like TCKD" evidence="8">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="TiaS FLD" evidence="7">
        <location>
            <begin position="155"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="TiaS C-terminal zinc ribbon" evidence="9">
        <location>
            <begin position="364"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="438" mass="49804" checksum="2AA5E113CE0A0FBB" modified="2017-06-07" version="1">MYVAIDDTDSQDKMCTTYLIYEIISRGEYDIIGSPELVRLNPNIGYKTRGNGALNINLGKGSGNTSIIGKANGKFIKSYEKVAGEPDKQELMDFISSIVEDFYVKDDDKTNPGIVISNDRFHSGLYGKALQDDISIEFIENYLSGRAIYRKIKTGHGIIGSSASLAWPGKRYTYELLDYRYPNYGDITYGEKIDISSIPESFYSTFNNIDIKNRYPAIFPKPKTPVIFGVRGVDKNDLITIYDRIKERHNIDDQGYIIYKTNQGTDDHIMPEPDYLSSMGSYSLTGVISGEPYTIEGGHSFVNFKYKNEEIKLAAFEPTKEFRKVLMSVIPGDIVSAYGSYAKGTIKLEKLRVIKKARLYRKEPPVCPECHVKTRSKGQMDYRCPVCKKRYKNPEITEITRELEEKFYEVPVIARRHLSMPLKLMPYFSDIPQTSGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N324</accession>
    <name>A0A1V0N324_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887632.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N324"/>
    <dbReference type="STRING" id="74969.FAD_0575"/>
    <dbReference type="GeneID" id="16025782"/>
    <dbReference type="KEGG" id="fai:FAD_0575"/>
    <dbReference type="OrthoDB" id="44171at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="76" mass="8262" checksum="0787370A6A09DAB2" modified="2017-06-07" version="1">MAKTVELKVYGMTCDDCVRHVSGGLKQAEGVTDVSVSLKDGMAVVKAMDTVDPENLLKLDVFKGQYKAQLKSVKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N328</accession>
    <name>A0A1V0N328_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N328"/>
    <dbReference type="STRING" id="74969.FAD_0588"/>
    <dbReference type="KEGG" id="fai:FAD_0588"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="82" mass="9440" checksum="FD3062C6170D45E2" modified="2017-06-07" version="1">MNIKEFQKICILKQIIAFMNYTNAGLWNCHLFMLKLQLHNSSTQGYKDSLKSGLTVAIGEINKVTIEIIWKFKIGHIQGIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N345</accession>
    <name>A0A1V0N345_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887666.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N345"/>
    <dbReference type="STRING" id="74969.FAD_0608"/>
    <dbReference type="GeneID" id="16025815"/>
    <dbReference type="GeneID" id="31676113"/>
    <dbReference type="KEGG" id="fai:FAD_0608"/>
    <dbReference type="OrthoDB" id="147504at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004452">
        <property type="entry name" value="PRK05785.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="27026" checksum="2AEB169BDC811E17" modified="2017-06-07" version="1">MKENRFMSDDKDLRDVYNKIPKSYDRANALISFFQDVKWRTRLVDGIFHISQPEKILDVASGKGELTYIIKQIKETYVVMTDYSENMLNMSIVDSTRVLASFNNLPFRDNSFDSVMSTFALHAADNIEDVIREMVRVSNGTVGVIAMGKSDNKFYSFITGFYLKYFQPYIAKLTGEKSKDYRFIYYIYKRLTPNSSIREIIKKYMDVVTFEEKAFGSVYIFIGTKKDTEVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N354</accession>
    <name>A0A1V0N354_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141775.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N354"/>
    <dbReference type="STRING" id="74969.FAD_0674"/>
    <dbReference type="GeneID" id="31676175"/>
    <dbReference type="KEGG" id="fai:FAD_0674"/>
    <dbReference type="OrthoDB" id="11709at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF0">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="19"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="428" mass="46749" checksum="EE9D8E85CDA49D83" modified="2017-06-07" version="1">MIISPVTYDYYEISFILIVAAFSIPISRKASMVYIPILIVMGLIFGPLLGFIKHSFAIYMLSSFATIGVGMLGLVIILYYESHNFSPRILRKYFYKIAALDTIGMVVTAVGAGIFFSLLTGAPMIIGFIFGAIISPTDPASLIPTFKKLNIRDDISGTLIGESLFNDPLGIILLSIGIGILAPNVSYSSFFTLLTSHVGLVLGSSSFLLLEIAIPAAVGIAFGFFIIYLNKYFNFESLLIALTLGIVLFEFTSLEAVGITPFPAIIATGAIVGNFSDKSIFWNRETNFNENLSFMAQSIIFILLGSILTRTQIFNYIIFGFIISLIVIFVVRPVAVFISIGLANMGKNTIKFDTRTKAFMLLVGPRGVVPVVLSTVPFVLGQANHIPLLIEYGTIIYASVSFVVLISIILQTIYVPYAGRLLLGERKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N375</accession>
    <name>A0A1V0N375_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0704</name>
        <name evidence="7" type="ORF">HLB00_02810</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000091">
        <property type="protein sequence ID" value="NOL59765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141814.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N375"/>
    <dbReference type="STRING" id="74969.FAD_0704"/>
    <dbReference type="GeneID" id="84217327"/>
    <dbReference type="KEGG" id="fai:FAD_0704"/>
    <dbReference type="OrthoDB" id="34275at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005027">
        <property type="entry name" value="PRK06436.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF178">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="51"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="93"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="296" mass="33026" checksum="4F14F460ED69599C" modified="2017-06-07" version="1">MIISLQVKFAAMDIPDDFLKMMEEKTGCKIVKGFSDDADIVVFAGKPEPGKKTVFMQSISAGVNHLDFRNIDKKIVICSNADAWSIPVAEHAMALILAKYKNICESNTAIRNGTYNRKLSESIYGQTIGIMGYGGIGREVAIRAKAFGMHTIGFGRTEKKDPALDVFSMESEYVAKNSDVILISLPLNKHTRGMIDYKFLSSVKGNIIVNVGRSEIVNMDDMIKFLEENKNKWFLTDVWWGEPEIKGEIPENVIITPHVAGLARNFMQVPVEKAFENVVAYIHGNPGNIVNRNDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N381</accession>
    <name>A0A1V0N381_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_0654</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141753.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="STRING" id="74969.FAD_0654"/>
    <dbReference type="GeneID" id="31676158"/>
    <dbReference type="KEGG" id="fai:FAD_0654"/>
    <dbReference type="OrthoDB" id="372104at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18796">
        <property type="entry name" value="SF2_C_LHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052511">
        <property type="entry name" value="ATP-dep_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="Lhr-like_DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010338">
        <property type="entry name" value="PRK13767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962">
        <property type="entry name" value="ATP-DEPENDENT HELICASE LHR-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962:SF6">
        <property type="entry name" value="LARGE HELICASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="WHD_Lhr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="39"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="268"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1698" mass="195712" checksum="5A58CA8B4BCD2CFE" modified="2017-06-07" version="1">MIYNNQFKVEETLPFLDDIVAQWFNTKYSELSEPQKKAIPLIHQKKNVLVSSPTGTGKTLTGFLSIINELFKKARNNELEDKIYCVYISPLKALANDINKNLNEPLSEIYTLAREKGLDIPEIKVAVRSGDTAQSDRNKMLRKPPHIIITTPESFSLAITATKFKEKFSSVEYVILDEIHEVSSTKRGSLLSFNLERLENLSPGFVRIGLSATQAPLDLIGSYLCGYNGEHKRDFEIIEVNTNKYLDLSIITPVKDLTMVSYEVANEKMYDILVDLVNSHKTTLIFTNTRSSTEHVAMRLKARGIENIEAHHSSLGKQTRIEVENRLKNGELKCVITSTSLELGIDIGYIDMVIQIGSPKSVSRALQRIGRSGHGVKDLSLGRFIVFDLDDLMECAVMTKAAYDHEIDKVTVPENPLDVLSQGIISMSLEKNWDVDVAYNVIRNSFSFHTLEYGDYISTLQYLSGKIEGNTLFSKIWYDEDEKVFGKKASTRMIYFMNVGTIPEEANYNVVNEKGRMIGQLSDKFVERLKNGDIFVLGAKTYMFLKASKNNITVKVATGMKPTVPSWTGELLPRSYDLGILIGEFRKTLYERIKNGEETEKWLMENYRVDSFGARSLISYVKTQGNFTIPTEDLLYIEGYIDNDLYSIIFHIPLGRRVNDALSRAYGLAVSNKYGANTRISVNDNGFTLTLNRKVPIKDVVGLLTPSNFRDLVDRSIINTELFKQRFRYCATRSLMVLRKYKQTDISVARQQLRSDRLLRILESMDNFPVIKEAFNEVKYDVMDVERAAWFVNDVISKKHYKIKDYSTETSPFSYNLILSGVSDIVLMEDRSKLLKELRSKLLDKIYGTEGIEFLIKDSKLVENYFKNKLPAIQDIESYREFLEHFLYVDPFRKKFDSPLEYATVDLDEMTEQLINSGELMYCFIRSDQWVSREYYPVVYHLFRREIELNSKDTEVYNHIDNSSFNELKKTGMLEQDLKDSLIKLESGYRIRKIIKNGNQYYIRNQEMPEKPANAMKQAVSLILSSYGPLSFDELLIRLPVDNGELETTLREMERSGSLIFDYITPIFMKQYMMKQDFDAIVNSTSYDVSRKRISNFSTDVASIEDYFEKYGFAFDVYDIKVRTSHFRLELLEKAIKNGTVFYTRAIKNKHVYIAKWLMDILYNLRAEKNGPEEAKILDYIEKGVDTEEKLSEITGFDIKIVKAVIKNLQFKIQVVNGPGGDIQVYNPETGIDVNNIIEKFGPITARELARFFWINPGKIDYSRFAPIYFRNEIYYGELPDAPENTSIIVRKNDPLSLYLGKYVRNDDYNARFIYHGSEETMFYMEEKEPGLWIENLDFESGKNTGFLETIQKAAERTGMDSIIIDSADQGLLDTASGYGYRVSGNYIYKGDFEVINMDMEGLLSMAVNLYGSRKGTMNYNELTRIFFGFRTDMEAYYSGIRNVELENYYSSMLIYTFDGPFNVQAYGTKNVIALYKAIRKRELTEEEETVYKYLISRNATENELVKSLKMNSFKVKETIKSLYSMNAIAKDKSKKYITINDEYTRIEAIEILLRELVKRIGFFDIKIYRNMVGIYTDVEYKLVVSKLLHEHTIREVLVPGENRLIYIGIDLPGKAIKHKISRIIPPKDIIALIFPDFIKLKFHTVNSYLFFMEDSIKLSFSVKKSGRYLGIKNIVGDTSYRDMARIEFNNTGYILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N388</accession>
    <name>A0A1V0N388_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbon monoxide dehydrogenase, medium chain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0651</name>
        <name evidence="6" type="ORF">HLB00_03640</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000115">
        <property type="protein sequence ID" value="NOL59925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141750.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N388"/>
    <dbReference type="STRING" id="74969.FAD_0651"/>
    <dbReference type="GeneID" id="31676155"/>
    <dbReference type="KEGG" id="fai:FAD_0651"/>
    <dbReference type="OrthoDB" id="19205at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000017">
        <property type="entry name" value="Xanthine dehydrogenase, FAD binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051312">
        <property type="entry name" value="Diverse_Substr_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42659">
        <property type="entry name" value="XANTHINE DEHYDROGENASE SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42659:SF2">
        <property type="entry name" value="XANTHINE DEHYDROGENASE SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="284" mass="30677" checksum="771CCB5408EFEB38" modified="2017-06-07" version="1">MFPEKFEYYAPESIEEATKFLNGHEDAKVLAGGQSLIPLLKLRFTSIPQLVDIGRLKGMDSISFQGNTLRIGPMARTHSIAEDPQIRKKFPILSEAAGLIADPLVRNMGTIGGDICHGDPANDFPAVMLALNATFEVTSAKGKRTIKAQDFFTDTFTTALNPGEILTGITIEDRNSSGRYMKYKKYAGDFSILGIAVNLSMDSGKIKEAGIGLTNCGATALKATEAEKFLVGKEVTDDNIAKAGDLLLKAADFMDDDNGSVKFKEKLLKYLFTKAVKGIGGVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N394</accession>
    <name>A0A1V0N394_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141755.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N394"/>
    <dbReference type="STRING" id="74969.FAD_0655"/>
    <dbReference type="GeneID" id="84217257"/>
    <dbReference type="KEGG" id="fai:FAD_0655"/>
    <dbReference type="OrthoDB" id="57066at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.76.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.105.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290:SF9">
        <property type="entry name" value="OLIGOPEPTIDE-BINDING PROTEIN APPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 5" evidence="5">
        <location>
            <begin position="75"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="676" mass="73465" checksum="94C66557A63221C7" modified="2017-06-07" version="1">MKKGLKIIIVVVVAIILVSTAFLVLYHPTHAFTDTSQTAAPEQLDPATGFFTTNGPLFSAVFQTLVEYNGSSTNVTPVLASHVTNLNDTHYIFTMRSGANFSNGQPLNATSAWFSFARGIVMGQGPYAADYSGTLFNGTMAGITGVYLPVGIIPALINAGYHISNTTYKVNKTVTMNTYNYTIAGNDLASILSHFNYNATEMKVMNYANQSLVVNSNGTFQINTEHKYAFLLSAIAGWWGDIVEPSYVDAHDGVQVNTPNSYLDANGVIGSGPYEISSVGKGFSTIVLKANPNYWVTSAMVNNGSISAIAKPASIKTVVIDYGLSHADRLEDFDRGISQISTVSPSSFKQMINGFHNKTERTGALVKSYNEIGVFYISMNTQRSYTNNTHFREALYNAMNYTAQLKVYNNNYNGTPEAYTELGPLSPVFGKAYYNPNNYPLPKQNLTAAIANITTAGKEMGFYVTLPNGSKVGDTSGTDLSHHTFAITGISPATSIETASMSAAISSFTHIGLTFKTSLVTESTVSGWTNASATPHFVDLGWLPDYLDPIGQQLIDVYSPAAGGAFGGNDAWVDNTSLNANFTNLDFKNISDQKQAMYNVQNLTYNQYAYMWTPMPDAVYFVAPNVHGFVYNNITSSYFYNMMTFTGKLTSSVGFMTLYTLVADIEMAFTNAAPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N398</accession>
    <name>A0A1V0N398_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0662</name>
        <name evidence="2" type="ORF">HLB00_07630</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000281">
        <property type="protein sequence ID" value="NOL60698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951099.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N398"/>
    <dbReference type="STRING" id="74969.FAD_0662"/>
    <dbReference type="GeneID" id="84217263"/>
    <dbReference type="KEGG" id="fai:FAD_0662"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="54" mass="6592" checksum="1C62C1050AFF215B" modified="2017-06-07" version="1">MASYVNSRCYYNLRKRFGHSIAGTIMNYWYYYNVDPPEDQDIALEYFILKRDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3A4</accession>
    <name>A0A1V0N3A4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3A4"/>
    <dbReference type="STRING" id="74969.FAD_0666"/>
    <dbReference type="KEGG" id="fai:FAD_0666"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="167" mass="19488" checksum="EDE737C3633DA8BD" modified="2017-06-07" version="1">MPVFGQAYLHHGDIMNRSENIKKINNYLRIFAIIWVFMISIVSYRLLYLGSIGNIISFSYNYYTGILPAILVALAALDIFFYLDYLKSKITHKHMKSNLALWILLVVMLSLYVFILPFFPPNIEPNIFKIFSYSMIFIITIIPFIVSLAIPIYLLVNSRGRVRTYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3C3</accession>
    <name>A0A1V0N3C3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3C3"/>
    <dbReference type="STRING" id="74969.FAD_0748"/>
    <dbReference type="KEGG" id="fai:FAD_0748"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="379" mass="43466" checksum="60DCD7F95BE14651" modified="2017-06-07" version="1">MNLEFAGGGEANARDIAELFVRQGYDVTLFGAGIPKGYETKAGKYSFNYVPDAFTFDIMATGPVLKFSHILSMGLIGIYTYNRIYEKIKDFDVYYFVSPTLLFRNVGYRLMKEGKTVVLGNHGTYFEVLDMYGFASKAYSKILTTMIFHKLLKNKMKFYIHVQNKYQAQYYEKIKCNRSYIREIPYNNVKFSGYKCLDNDNFSVVYLGRLMESKGVDMLLELEKKADINLHIIGKGPYMEKLQQMKNKNTVIHGYVSNAEKIKLLAESDVMIVPSINESLSISAIEGLASGLYLIVSSTSMGPRYIVRQDNIFGVAVPRNPKNFIKEIERIKIIKERSKTDFYSEKMLRREIAGKMFDANVVDKELVDLFNDAIKDSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3H7</accession>
    <name>A0A1V0N3H7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0796</name>
        <name evidence="8" type="ORF">HLB00_02130</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000061">
        <property type="protein sequence ID" value="NOL59631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887896.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3H7"/>
    <dbReference type="STRING" id="74969.FAD_0796"/>
    <dbReference type="GeneID" id="16026016"/>
    <dbReference type="GeneID" id="31676298"/>
    <dbReference type="KEGG" id="fai:FAD_0796"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="400" mass="43926" checksum="4C9216B3CB9C2AB3" modified="2017-06-07" version="1">MLMSSASGLTFWGIVATLGPLAAAGSIIGVLPHSYKVLVLLIGPLFVPFGNFTMGILTDRIGRKKIFLITMIMYGIGIVIISLSYTFIPLIIGLMLAEFGVGGEEIPSLSLVSEDSPISQRAKWLTIISDFDNIGSAIIAGLFLVLVTSFADRVVLLLAASFLIIVMIFSRLSLPESFKWENIHGKVENSIKTRSSLYIDSAGETVKKPSYTLTLSVLMAMAISQYTTFGLMAYIIGPYEFPGVFTDDMIIFVALLGASVAGFIAAPLITRGRKKYTLYSYGLGFISTVAIFLVIPLLNNVLIFYPLLFFNMMMSEFAWASRTTLEPELSPTRIRGIFMGTVRLAPMIVYPLLVYLTSNVSIRVFIIINVGLWLLGFIAAIVWHHYGIETAKVNIDYPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3J8</accession>
    <name>A0A1V0N3J8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sugar fermentation stimulation protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sfsA</name>
        <name evidence="4" type="ORF">FAD_0781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SfsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141960.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3J8"/>
    <dbReference type="STRING" id="74969.FAD_0781"/>
    <dbReference type="GeneID" id="31676283"/>
    <dbReference type="KEGG" id="fai:FAD_0781"/>
    <dbReference type="OrthoDB" id="34139at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22357">
        <property type="entry name" value="SfsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00095">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="SUGAR FERMENTATION STIMULATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545:SF2">
        <property type="entry name" value="SUGAR FERMENTATION STIMULATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SfsA N-terminal OB" evidence="3">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar fermentation stimulation protein C-terminal" evidence="2">
        <location>
            <begin position="104"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="226" mass="25802" checksum="17739967C49AEE76" modified="2017-06-07" version="1">MYPFIERESGYVVAKFPDLIEAKVVSRPNRFMVKAMVDDKEVDVHIHDPGRLEELIFPGNSILIRETNGTKTHYSVTFCKNGDIWTFNDSRYHSGIASMFIQEGWQREVKVGNSRLDFRLNNAYIEVKSATLVENGIARFPDAPTLRGKKHLETLMDLIASGYESFVLFLIFNEDAKCFLPNTARDPEFSHAYYSALEHGVKFQYLVFSSRGGEIVLKDSISMCNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3N5</accession>
    <name>A0A1V0N3N5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142001.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3N5"/>
    <dbReference type="STRING" id="74969.FAD_0809"/>
    <dbReference type="GeneID" id="31676311"/>
    <dbReference type="KEGG" id="fai:FAD_0809"/>
    <dbReference type="OrthoDB" id="43754at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="161" mass="18397" checksum="61DBA98EEF8D9066" modified="2017-06-07" version="1">MPDVVIGHSITVQLPHGFRLIKASDTGKEFISEDRKMRDYKISYFYDWSREDNNIVIVHESPDGKLSGVVMFRLVPNIYHPKRIVVEMLARNFASAGSSGSGYDLLKVIENNVARALHIKRIDIEAVKSLKSYYNSLGYEETGENYYDSSWKEIVNMSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3P3</accession>
    <name>A0A1V0N3P3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3P3"/>
    <dbReference type="STRING" id="74969.FAD_0821"/>
    <dbReference type="GeneID" id="31676322"/>
    <dbReference type="KEGG" id="fai:FAD_0821"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043958">
        <property type="entry name" value="Ta1207"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19020">
        <property type="entry name" value="Ta1207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="312" mass="35986" checksum="ED049F63CD7FB537" modified="2017-06-07" version="1">MKLSRIDTKLNKYFEIALNFKSNHLALSQATGYDGAGALVRDGDDLFFDFFILKSEDIGRLKPLFQLAEVNEREHYFLVREKMTDPALVEFFTDLDNINGLVISYAGIESGNMIIKGFMHENSEMDFSNLIYKYNYTEFNIVQITLKPSPGFYYFMKNTDTALQSIIVSLPVAEFSQYRVIKILKETNATVQFVDNNPIHGSFRAIIYSDRDLSSVENMTVISERDHIYETKTNDSILLLLASKAMSNNLTLNFMFLYVYGDRLVINFILPTYRAKDYFKQIIDTEIDLNNFEWLTLESYGPVNDGNMESDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3P9</accession>
    <name>A0A1V0N3P9_9ARCH</name>
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        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141985.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3P9"/>
    <dbReference type="STRING" id="74969.FAD_0793"/>
    <dbReference type="GeneID" id="31676295"/>
    <dbReference type="KEGG" id="fai:FAD_0793"/>
    <dbReference type="OrthoDB" id="6762at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="147" mass="17102" checksum="9A5C99B537424CFA" modified="2017-06-07" version="1">MLENIDKKDMKIIEYLKEHGRDKSSDISNALQIPRATIFERMERLRKDGFIKKYTVDLNYDKLGYSVMSYIMIQYNPKASIDQRTLCLNLSKMDNVISASIVTGDWDIVLLTAQKSMRDLSKFVLEQLRTMDGIEKSVTIPLFERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Q9</accession>
    <name>A0A1V0N3Q9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Four-carbon acid sugar kinase nucleotide binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887925.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Q9"/>
    <dbReference type="STRING" id="74969.FAD_0817"/>
    <dbReference type="GeneID" id="24787227"/>
    <dbReference type="GeneID" id="31676319"/>
    <dbReference type="KEGG" id="fai:FAD_0817"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="entry name" value="Four-carbon acid sugar kinase, nucleotide binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142764">
        <property type="entry name" value="YgbK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Four-carbon acid sugar kinase nucleotide binding" evidence="1">
        <location>
            <begin position="64"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="137" mass="15219" checksum="773D69463F46D4C3" modified="2017-06-07" version="1">MDKIGIIIGSLTVITEKQVEYLKRTLRSDSLNIKNCPEIKLFYLQETDFSTVKDMGFISLLMECNALIMSGGETAFCVLNTSGFNYLESEEQILPLISTGTVHGGMLDGKRYVIKGGSLGDDDIYIKLIQHLSINTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3R3</accession>
    <name>A0A1V0N3R3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TENA/THI-4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951108.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3R3"/>
    <dbReference type="STRING" id="74969.FAD_0841"/>
    <dbReference type="GeneID" id="31676341"/>
    <dbReference type="KEGG" id="fai:FAD_0841"/>
    <dbReference type="OrthoDB" id="56558at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032553">
        <property type="entry name" value="UCP032676_Znf-C2H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279:SF3">
        <property type="entry name" value="4-AMINOBENZOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PQQC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16293">
        <property type="entry name" value="zf-C2H2_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="2">
        <location>
            <begin position="82"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="298" mass="34887" checksum="4FF10386C7349D3A" modified="2017-06-07" version="1">MAICPVCNLKFGNNDFLALSEHFTGKAKDSDALHVMWLNRNITKTKADKNSLELLFRNLYDLNGEGIKSWIVNRFVSEYRGNNPHPFIIKMQDYNKYIMEGYAVEHYFFLKQWVRSCSAVISKTDYKDVQTYEMENMTTEYFGNGKKSHIELLLDMAEGFGISRKKIMETKPLKNTEKAISRWREIAQKNEWIEIMAAMHSLELIANSALRPYGARYNYFNLDAFDNNNVPETVKAFLMEGYHSDNAHSMGALNIIEKYSRDYNIENIQDAYLASTYVFYNYLEARIERGEMIENKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3S2</accession>
    <name>A0A1V0N3S2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mercuric ion binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142169.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3S2"/>
    <dbReference type="STRING" id="74969.FAD_0910"/>
    <dbReference type="GeneID" id="31676413"/>
    <dbReference type="KEGG" id="fai:FAD_0910"/>
    <dbReference type="OrthoDB" id="44171at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="76" mass="8424" checksum="54864EAAA31B2FE3" modified="2017-06-07" version="1">MTKTIELRVYGMTCDDCVEHVSSGLKNANGVNDASVSLKDGMAVVRTIDKTNPYDLIKLDVFKGQYRAQVRSVKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3S5</accession>
    <name>A0A1V0N3S5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142190.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3S5"/>
    <dbReference type="STRING" id="74969.FAD_0924"/>
    <dbReference type="GeneID" id="31676428"/>
    <dbReference type="KEGG" id="fai:FAD_0924"/>
    <dbReference type="OrthoDB" id="14887at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050128">
        <property type="entry name" value="Sulfate_adenylyltrnsfr_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43196">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43196:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="273" mass="32327" checksum="80F5C7CB0819B90D" modified="2017-06-07" version="1">MDYEYKKREEKYLSLDAKVNISKVVIDDAMDDFIRPAVLWSAGKDSTVVLDLVKTVARDRKMAIPPAILIDHGQHYDETYKMVKDISKEWGFKVIYARNDNFLSKVDNNRVNVDDLNEDNHEELRKINFDFSKKYIDYGLETLEGNHLLKTAPFNDVIRRYRFDSLYTGVRWDENEARSNEVFISERTDPDHVRVQPVITFREKDIWKYMFDNKLPIHPLYYKGYRSIDGKYDSTKTSDSPAWEQDLENTAERAGRAQDKENMMDQLRKFGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3V6</accession>
    <name>A0A1V0N3V6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin biosynthesis MoeA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142147.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3V6"/>
    <dbReference type="STRING" id="74969.FAD_0899"/>
    <dbReference type="GeneID" id="31676402"/>
    <dbReference type="KEGG" id="fai:FAD_0899"/>
    <dbReference type="OrthoDB" id="31371at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="187"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="584" mass="64428" checksum="792FD4612182D4FF" modified="2017-06-07" version="1">MGLIFHDLTKFQDALEIIKKNMVELKDAEEVSLYNATGRISAETIFSNNNLPLFSRSQVDGYAIIASDIKGASYDSPVSLKLAGETNIGEKAVKFPGSGKCIKVPTGGVIPVGADAMVPFEDTKQEGNSIQFFHEVNRFNELSNAGIDVIKGEKLLDSNVIIDPRNIAVLASTGIGKIKVKRKLTIGIVSTGNELLYPGTPYKEGKIFESNSLSIKAELSKYPAFNVNDYGIIEDNYDKIKNAIDGSIEENDVTLTIGSTSAGDHDMVYKILGEKTPGIIFHGIRVKPGKPAIFAMSGEKIIFGLPGFPVSSMMILYSLVMPNLFRKTGYEFSEVAVDAITGQRFELHQGNTDLLLIKLVKHGETYKAYQVPGNSGSISRISKATGYSIIDSRTSFMDINSKINVKLFTGNIPSILIYGQYLPAMEKLPSSVSGLSTFVESGFNEIKRSMENADADVYLWNYEELPDDKNYDSSITIEIPYGIAYTEENYSTMAIPYRGSGLYEKSLAIAEGVDLTYLDKPEIICDYVKNRRCGAGITYREYAELYSLKFIEKGKITFHVYINKNSTKFNELKEAFNSIAGKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3W0</accession>
    <name>A0A1V0N3W0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795572.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3W0"/>
    <dbReference type="STRING" id="74969.FAD_0949"/>
    <dbReference type="GeneID" id="60420011"/>
    <dbReference type="KEGG" id="fai:FAD_0949"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="45" mass="4976" checksum="21077E30F9827F78" modified="2017-06-07" version="1">MGDKKSNDQRSNVYNPTSSDNKAAGDNKSNQMNPNNSAYRKSRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3W7</accession>
    <name>A0A1V0N3W7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951119.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3W7"/>
    <dbReference type="STRING" id="74969.FAD_0909"/>
    <dbReference type="GeneID" id="31676412"/>
    <dbReference type="KEGG" id="fai:FAD_0909"/>
    <dbReference type="OrthoDB" id="42128at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="328" mass="38729" checksum="BB8B6858D024D150" modified="2017-06-07" version="1">MVDASVVIFDYDRKEFIKDTIKSIVSNIGNHNIEILVIKSYEDGEIDEFLKNNNVKFVTLLDNKSQSDYIKCAVKESLGEILMFHDDDDQFANDKIGYVCNLFNQHEDLGYYHNNFNTIDQEGNAVYNRNYKTPEFASLYIKNSEKTLYFNKKIKLINYIRPDFNATSICIRKSIITDFHKNFEFNVRPDTFLLIMALLSDLSLFFDNKVLTHYRLYGDNVSTSYNAPVTKMRKTFMKAFLEGTKIFSYYLNFLEDTPYSYYLQLRIINLKLAYNFWALKRKYKITHSELKIIFQADLLHESEYYIISILPARLKLLVMRLAYNAIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N405</accession>
    <name>A0A1V0N405_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N405"/>
    <dbReference type="KEGG" id="fai:FAD_0935"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="108" mass="12561" checksum="7F074D88BB7C4B7B" modified="2017-06-07" version="1">MTKNKIESDYLLSRINEMFKIVDISNPIIIAQSEKNAIQINKTQNYDRVPIKGENDNIEEYYDSNAQNRNKIIKIKPNDLISEIVSIILCIYKGYRLLNISFISSLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N421</accession>
    <name>A0A1V0N421_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Csc1 (Cas5)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cas5</name>
        <name evidence="1" type="ORF">FAD_0942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142210.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N421"/>
    <dbReference type="STRING" id="74969.FAD_0942"/>
    <dbReference type="GeneID" id="31676446"/>
    <dbReference type="KEGG" id="fai:FAD_0942"/>
    <dbReference type="OrthoDB" id="64042at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017576">
        <property type="entry name" value="CRISPR-assoc_prot_Csc1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03159">
        <property type="entry name" value="cas_Csc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26241">
        <property type="entry name" value="Cas_Csc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="219" mass="25118" checksum="810BEA0A838F67DA" modified="2017-06-07" version="1">MKILPLKMTALSPIQYFYSAAAGGMRSSNFIGDIALKYAFLRQMGLFKLPEPGKSKPTYEELLDFQFWLTVGVPAKLAFGTGDNTIYMKNMIRNTMQGADYNGSNVHPNFKTGQLMYKNFFFVQPLKPGNIFYSFLVYDEKHFDSSKLPELIRVGNNKTGILKVDKCDKNFKGVINAYTIQNILGKTLKINKNEYVSHLILQYFLMGYYSMEEILDVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N426</accession>
    <name>A0A1V0N426_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CopG family transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142228.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N426"/>
    <dbReference type="GeneID" id="31676455"/>
    <dbReference type="KEGG" id="fai:FAD_0954"/>
    <dbReference type="OrthoDB" id="7794at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8670" checksum="938F923DDC7B575D" modified="2017-06-07" version="1">MEDEITTIQLKKSVVNALKEIKKYPRETYNEIILDLINDARETHELNTFVQKAQESKMKELWEEGDYSGWEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N451</accession>
    <name>A0A1V0N451_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142287.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N451"/>
    <dbReference type="GeneID" id="31676485"/>
    <dbReference type="KEGG" id="fai:FAD_0986"/>
    <dbReference type="OrthoDB" id="132045at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704:SF2">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="3">
        <location>
            <begin position="308"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="459" mass="54001" checksum="CDAF12AF65411FA0" modified="2017-06-07" version="1">MIPERMFVDRINELNNLEDLNNENRAQLILIYGRRRIGKTTLMYEFLKNKDNSLFFIADASENILDTFSDIASEKFNNVRFQNWDNFFDFLYSISKNNRFIVVIDEFQYLTSVLKSWPTILQRHWEKLKTTKIFLILSGSLISSIYRIAIGYGTALYGRKTAEMNIKPLNFIESRNFFKTDINNLARIYMVLGGVPRYLEEFDSGNIYNNIKKKILNKNSYLYNEPINLLHEEFKDLTSYFAVLDTIGSGATTFNEISSKSRITQNKLSKVLDVLIRAELIAREDSIIKSNVRNKHIYYIKDNLFNFWFKFVYPFRSLLEMNNEEVVISKIKNEISTLFGHRFEFLARDLLLHNQDKLPFAISYIGRSWGKLKNKVGSNSNYEFDVVIQDSQKYHTGIFEVKYKELSYGDAYKIIQNMQEIYNNISVNSHPVFGIIAKNIENKELLRKNGYYVFDLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N452</accession>
    <name>A0A1V0N452_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Archaeal glutamate synthase [NADPH]</fullName>
            <ecNumber evidence="3">1.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142403.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N452"/>
    <dbReference type="STRING" id="74969.FAD_1041"/>
    <dbReference type="GeneID" id="31676540"/>
    <dbReference type="KEGG" id="fai:FAD_1041"/>
    <dbReference type="OrthoDB" id="57305at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043578">
        <property type="entry name" value="GltB_archl_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43819">
        <property type="entry name" value="ARCHAEAL-TYPE GLUTAMATE SYNTHASE [NADPH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43819:SF1">
        <property type="entry name" value="ARCHAEAL-TYPE GLUTAMATE SYNTHASE [NADPH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500061">
        <property type="entry name" value="GOGAT_lg2_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate synthase" evidence="4">
        <location>
            <begin position="69"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamate synthase central-N" evidence="5">
        <location>
            <begin position="428"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="694" mass="75163" checksum="32B2554BD3F8C6CF" modified="2017-06-07" version="1">MDNTISKFIELPVQKRVDFWSPQKIGHIRKLSGSGIASEIFVENNESLRILDNIVFRENKSHAIPNMDMQTDTMLAGMKLSVPVYLGDMSYGALSGNPNIAIAKAAEITETMAGTGEGGLYGSVSGSKRIFVQWASARFGVSAGSLNQGASIVIKIGQGAKPGIGGHLPGSKVTHNISLARKIPENMDAISPAPHHDIYSIEDLTQRIEALKILSDKPVFVKVAATNYIPYIVTGIARSGAAGVIIDGHGAGTGAAPVAVRDNMGIPVELAVASADSILKKENLRKNFTIIAAGRVSNSTDAMKLYALGADVVSLGTSILIAMGCIMVKKCNLGYCPVALTNRTDSSKSLDIDFAVNRVVNFINGFRSEMAEMMGKLGINSMKELTGNRDLLEARNLSGETMELLGIRYGNPVDLDPIQGNFEYDIKYLNSLINKGEPVMSSMGSNAPPEVDKPARIIDWLRLDGAQVTRPSIDPYRENINLDFYLSGGDLVISMPVIINVNGADKNVMEALEWASLFIGSVTIDYNPEMDNPEINFHGTHSGKHRYSFIASGENLDRNAGGFILEEDRYTELKITEINDILGKEGIRENYDLILEVSRFRNSGDIIKYLALGCDSVILSSKIFESGLENNYSNLNEKALNFLMGIRKELALLSGAMGISNLQYSIVGNKELLRSVNLDSNIGKAINIQEGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N453</accession>
    <name>A0A1V0N453_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N453"/>
    <dbReference type="STRING" id="74969.FAD_1004"/>
    <dbReference type="KEGG" id="fai:FAD_1004"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="447" mass="52988" checksum="04298835FE793F8F" modified="2017-06-07" version="1">MHLYLLMEEGSGHIEVKKIKGKLYAYYTVNKWDKRTKKEIKKSKYMGRVKDDRIIQKDFVLPEKSLQYGDIALLMGLNKDLVIKILRGFTKYKREIIVLAFIISLYGSPLAFSKYYYKRTFLSYIWPRIRLNEENIPGILKELSSERNLYESMNTIEENMLLMHIEISINVQTLNKNNASPVIIDILIDALTLKVINVKHMAGVNDSVGQFIDLCDRIANNNGVIIPEGKYYNKKNLKILMDGKRNFIMEIDEIQLPKIKEMLKIDKLLLKREYNELLKHDLYYTKYSSGNIFYYFFYDKILNGREIIEANANVKIVLSNLDINQNLIYQAINIRNFLYKKLLYSRYRIYNDSFYLKNNMSVDGYLILNSIALEMYLLLYRYSDFIYPYRSKYIDTLLLELSGVDLFLIKNKLYLPKITKNIDKKLNSINKDINIKDFESLMLYRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N477</accession>
    <name>A0A1V0N477_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type peptide/opine/nickel family transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142344.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N477"/>
    <dbReference type="STRING" id="74969.FAD_1015"/>
    <dbReference type="GeneID" id="31676514"/>
    <dbReference type="KEGG" id="fai:FAD_1015"/>
    <dbReference type="OrthoDB" id="56961at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43067:SF3">
        <property type="entry name" value="MALTOSE ABC TRANSPORTER, ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43067">
        <property type="entry name" value="OLIGOPEPTIDE/DIPEPTIDE ABC TRANSPORTER, ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="300" mass="34670" checksum="B63A772111D403F4" modified="2017-06-07" version="1">MLQVNNLHSGYYSDKKYTEILKNINMHVEDHEIVGVLGANGSGKTTLMKSIMGDIYASEGDVLYNGKSIYRKENYGKYRRVAIYVKQDSFNSLKPLKTVNFQIGKLYDWKSFDKEYVRLLFKELNLDPEIFNMKAIQLSDGMRHRVVIAMALLTNPELLVLDEPTTGLDSISTYNLLIMLKTIKKKASVLFSSNDVNALFQVCDRVYILYGGEIIEDGEYSRILGGPFHPYTDTLLKYVPLYSNRNREYIEINNKKYGGCVFINNCRYWTKECETQIEYRTINNHGVRCINYPGWKNDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N499</accession>
    <name>A0A1V0N499_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142411.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N499"/>
    <dbReference type="STRING" id="74969.FAD_1046"/>
    <dbReference type="GeneID" id="31676545"/>
    <dbReference type="KEGG" id="fai:FAD_1046"/>
    <dbReference type="OrthoDB" id="56801at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="SLFN-g3_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Schlafen group 3-like DNA/RNA helicase" evidence="1">
        <location>
            <begin position="249"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="617" mass="70014" checksum="C88381AB7FD6DBEA" modified="2017-06-07" version="1">MNYLYYNNTKSFLEEYNKDFPDALANKYRELFHVSPGLYLYNSWKGSIAYLYNLITALNSKGIVLEYIIPAGGERADAIFVGNTVSPSLMIIEMKGWRTMEIVDDYSVIADNKKEVNPSYQVLNYSGKIKYSIEGIENFNINSMVILYNILNHNKSMDGIYSGNERELIIKELKKNLDPGFDPHSLTTFVNARYRQNINLFEAVRKYHLDIKNGAMKALASEGYGLYSEQLEPYLEIINNLLTGTPGNYIIHGGPGSGKSLIALNLLLRSSAMGKQSVLSYRNNRMVASLRKLLDSISTGMSTLIKYYSTGRPGNPGVAEDKFPVHYDIAIFDESQRMTVKNIKNAGKVADISVFFYDDSQILGTREQGTQSNFLKYLENPHEITLKGLYRNGNEYGEFVNKLLKGESTIYPEPYDLQYFPDIKCLINTLKTKIDLGKKSALVASFTEAKGNIHDINSQDNIRIGDRIPSGLNLYSGTGIAVRWLMDPKKEYAPFWVGGESNKLEKCASVYGAQGFEADYTGVIWGRDLVRRDNKWVLGDNCEDFEIKKLFFKGKNGDKTSYDTAIELLVNRYRILLTRGIYGTYIFCEDSETGEYLKRQCHVEMDLNDRSNSMDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4A5</accession>
    <name>A0A1V0N4A5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4A5"/>
    <dbReference type="STRING" id="74969.FAD_1054"/>
    <dbReference type="KEGG" id="fai:FAD_1054"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="45"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="472"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="675" mass="78640" checksum="1AD1B9C51A5F6223" modified="2017-06-07" version="1">MKRLIEIQLSGIMASRLDRIPVISEKEKPEKPVFSIDYLDKSYDPMDDFSMYSYGKWARSHPVPEDKYVYDASTELMEWNNFILGKILESCAQNSQNHAERALGDFYISIMDVDEIEKNGFKPVSRFMEIIDRIDSKNNIIETLGEFNTMGISGLFSFDSMPDEKNSSVYACYLNQDGLSLPNRDYYFDDSFKEIRAQYINHIKNMFILYGFDDKTSENMGNTVLKIETSLALKSRSPVELRDPDKNYNRFQFNDIEKEFPGLHHREYFSKIGLTGLDYIIIGQPEFFHELNPVIQQYTLDDWKIYMKWNVLNSAAPFLFRDVEMEHFDFFQRKLLGQQLPAKRWKKAVSIIDSFMGEALGKIYVEQQFGEDSKRRMDEMIEDLKEVFIERINNLSWMGRETKEKALEKFSKFRAKVGYPSKYIDYSSIKISQDRLFENIINCNKFELERETKRIGKPVDKELWEMTPPTVNAYFSPTDNEIVFPAGILQPPFFDPEMDDAVNYGATGATIAHEISHGFDDEGRKYDLNGNLNDWWTPEDDKAFTEKAQSVVDLYNSIEALPGIHVNGPLTLGENIADIGGVSIAFEALERRLKKNPELRKVIDGYTPEQRFFMGWAQSWRTTVKDEALKWQILNDVHSPEKIRAEIPAYVNPNFQHTFTGLSNNNLKYREIIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4E1</accession>
    <name>A0A1V0N4E1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1094</name>
        <name evidence="10" type="ORF">HLB00_00880</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NodC/HAS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000025">
        <property type="protein sequence ID" value="NOL59393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4E1"/>
    <dbReference type="STRING" id="74969.FAD_1094"/>
    <dbReference type="KEGG" id="fai:FAD_1094"/>
    <dbReference type="OrthoDB" id="46222at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="39"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="403" mass="46025" checksum="63472FBB2B550985" modified="2017-06-07" version="1">MALLAVTVISFIYYLLNAYYSTYYRKGETISNVNPDEATIVMPVYNEDVEIFRQAIVSLALQGSKFIVVGDSSLEPYKTITEQNGGRFIYLSQRGGKKNALVQGIKHVSTKYVMFVDSDTIIPADTLKSMLSYFSNGIAGVGVNIHIKNDGTNISYASEFIERLTEMISKSMSRHGNVYVLDGRCAMYITDVVKPFMVSDEFLNKKIFGKKVVLGDDMQLTSFLIKNKYKMIKDYDITVETEPQKGTRKFLNQQIRWSRRGWYFFFKNLSDGTTKNGGKFYAFEMFYIYLIPIIGFILFLFRGMFILRFLGHIDYLSVSSVNYLIMAHLLHLHSHDILGSLINGIMYTLGAIGDSIFVGAIMIRIPKNRIRTLAYGAMGLGVLFFVNLYGLFTFWKQSKWLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4F5</accession>
    <name>A0A1V0N4F5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily multidrug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886209.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4F5"/>
    <dbReference type="STRING" id="74969.FAD_1106"/>
    <dbReference type="GeneID" id="16024335"/>
    <dbReference type="KEGG" id="fai:FAD_1106"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF46">
        <property type="entry name" value="BLR6921 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="4"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="399" mass="43835" checksum="34DC492ABBDFC629" modified="2017-06-07" version="1">MNKKIVFTSLPGFTAALEATMILLAIPEISKEFSISYSESTLLIIIFVITETLLVIPFSLIADKKGIKKVMITGSFIMLIASILIFISNNFIVMLLLRAIQGIGGSMVILTSLSYASLISSDINRGKSIGLNHTIISLGYVIGLPLGGLMASINYKYLFLFTAFLSLLSIILIINIDEIKGKSEIGKSSFYITLLFSGLILSIYYIPFIIIAIIGLVLSFRIKLSKEFSLSSFSGFLHSITRNMLAAYFVFLLYSLKYSPLIVGLLVLIYPLFFTFTSFISGKLHDKYGLKIASLGFLSMSVFSLLLFFNFLFPEVFLGSSTGVATTSNTAYTMNSLNKNDRITGSGIRSLQGIVTNAIGLGIASKLLLNLNYVILIIIIFNLTALSITLILYKNKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4P0</accession>
    <name>A0A1V0N4P0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">UbiA family prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1222</name>
        <name evidence="7" type="ORF">HLB00_08750</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000331">
        <property type="protein sequence ID" value="NOL60909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142629.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4P0"/>
    <dbReference type="STRING" id="74969.FAD_1222"/>
    <dbReference type="GeneID" id="84217816"/>
    <dbReference type="KEGG" id="fai:FAD_1222"/>
    <dbReference type="OrthoDB" id="11851at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13961">
        <property type="entry name" value="PT_UbiA_DGGGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="270" mass="29923" checksum="B2358698C09F204C" modified="2017-06-07" version="1">MNKWIKITRPVNGLMGFFSIYIVGFIAVNLHIAEFIIPLTLGAISVFLVTAGGNIINDISDVETDKYNHPDRPLPSGTITKKAASYLAISFFIIAFIVSTFISIFISVVVVIAELLLVSYEFKTKKIGLPGNLTVSLLIGMIFLYGGFITGTISKMLLLFLLAFFSNMSREIMKDIEDINGDVDRVTFPKKYGIGMAKIVSAIFVVITISVSVLPYYFHVLSIYYLYAVVLDDLLFAITIWYLKANISRGEKVSKVAMIYGMVCFLIGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4W4</accession>
    <name>A0A1V0N4W4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Anhydromevalonate phosphate decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.126</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FAD_1314</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of trans-anhydromevalonate 5-phosphate (tAHMP) into isopentenyl phosphate. Involved in the archaeal mevalonate (MVA) pathway, which provides fundamental precursors for isoprenoid biosynthesis, such as isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2E)-3-methyl-5-phosphooxypent-2-enoate + H(+) = isopentenyl phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:78971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:229665"/>
            <dbReference type="EC" id="4.1.1.126"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:78972"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.126" evidence="10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142790.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4W4"/>
    <dbReference type="STRING" id="74969.FAD_1314"/>
    <dbReference type="GeneID" id="31676807"/>
    <dbReference type="KEGG" id="fai:FAD_1314"/>
    <dbReference type="OrthoDB" id="8480at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1670.10:FF:000003">
        <property type="entry name" value="Phenolic acid decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022390">
        <property type="entry name" value="HBDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03701">
        <property type="entry name" value="mena_SCO4490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="14">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="13">
        <location>
            <begin position="127"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="15">
        <location>
            <begin position="320"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD85180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="481" mass="54803" checksum="AFD5FB6033FDA19D" modified="2017-06-07" version="1">MTFDDLKEFIKYQESNGDLVRVNEEVDPELELTYILSEEERIGKKRTMLFNNVKGSKMPVIGNIFSSDKKIEAILGDTPYNIGLKLKNLVRIPDDTESMISRGLEMLKEMSGIKPKVYNRKNSEFEVVEPHLSDYPITKNWPGDGGRYITMPVVMTKDPDTGTRNVGTYRMQVYDDETVGMHWHIHKGGAEHMDKYRNEGKIMDVAVAIGVDPLTFFSSIAPLPNGIDEFSFRGILAKKHLELIKGETVNMEYPRSSQIVLEGYIDPSETRIEGPFGDHTGYYSLEEAFPVFHVKKVVQKLEPVYSTTIVGKLWHEDVRIGKAIEKMFLPLIQIQIPEIVDMNIPEETVVSNMIVVSIKKRYPGQAKKVMFAIWGTGQMMFTKIVVVVDDDVDVHDMKQVMWAMTTRIDPVNDVFMVPNTPTDSLDHPARLFNLGSKMGIDATKKSPAENYNRPWPDTLSMTPEIERKADELLKKLEQPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4W8</accession>
    <name>A0A1V0N4W8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1316</name>
        <name evidence="2" type="ORF">HLB00_01065</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000028">
        <property type="protein sequence ID" value="NOL59427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886417.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4W8"/>
    <dbReference type="STRING" id="74969.FAD_1316"/>
    <dbReference type="GeneID" id="16024542"/>
    <dbReference type="GeneID" id="31676809"/>
    <dbReference type="KEGG" id="fai:FAD_1316"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="66" mass="7552" checksum="EAF6C93922899A0D" modified="2017-06-07" version="1">MADVKFCPSEAHIQVKKGLIRRSSTQENYPMERLYVQDIVEGAVSYRAVGWLCDKCKYVEIDGTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Y6</accession>
    <name>A0A1V0N4Y6_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1335</name>
        <name evidence="3" type="ORF">HLB00_09040</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000364">
        <property type="protein sequence ID" value="NOL60964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142814.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Y6"/>
    <dbReference type="STRING" id="74969.FAD_1335"/>
    <dbReference type="GeneID" id="84217947"/>
    <dbReference type="KEGG" id="fai:FAD_1335"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="112" mass="12414" checksum="2609F7773C44B6A1" modified="2017-06-07" version="1">MNDKYFNIYGIFILIITAFLLGYYGYWYLQIVPAILIGYFMVRKISYIVLAGVASMLGIFIALIPSYATRIRGASLASSIAGIPFYLVILLTFLIIFVITIAGLLIGSSINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Z8</accession>
    <name>A0A1V0N4Z8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2 fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142787.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Z8"/>
    <dbReference type="STRING" id="74969.FAD_1310"/>
    <dbReference type="GeneID" id="31676804"/>
    <dbReference type="KEGG" id="fai:FAD_1310"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="8519" checksum="73E217EA6FCABD68" modified="2017-06-07" version="1">MEDRNTAAAFIREYIYHNYEGVENIRIREMKFDKYTGNWTSHTSFNDIDRSYEIAIVFNKDKIIFVKEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N525</accession>
    <name>A0A1V0N525_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142821.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N525"/>
    <dbReference type="STRING" id="74969.FAD_1341"/>
    <dbReference type="GeneID" id="84217953"/>
    <dbReference type="KEGG" id="fai:FAD_1341"/>
    <dbReference type="OrthoDB" id="57092at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052017">
        <property type="entry name" value="TSUP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30269:SF37">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30269">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YFCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="331" mass="36281" checksum="BF7B8EE7D92BAE3D" modified="2017-06-07" version="1">MTLLLIALKFLTIVFGSIIAGFIGSLTGLGGGTVLVPVLTLFYGIPFIFAAGASLISTIATSAGSASAYTKKKIANIKIGIGLEIATTTGAIVGSLTLVFIDKHALIWSVYVIFGLVLLFSLIPTIKKIGKEVPPETKPDWSTKLFQLTGSYYDERLRKTIKYHGIRWWLGEIVMFFAGFVSGLLGIGSGALKVLGMDWAMNLPMKVTTTSSNFMIGITAATGSSIYWYEGYINLFIAAATAIGVLIGAFFGAKVLVKISNENIRWIFFAILSFLGFDMVFKGLHLINFLITFSLMIQFFISVIISIVLISLLFYNSKRKEWRKVNEKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N553</accession>
    <name>A0A1V0N553_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1376</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142864.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N553"/>
    <dbReference type="STRING" id="74969.FAD_1376"/>
    <dbReference type="GeneID" id="31676868"/>
    <dbReference type="KEGG" id="fai:FAD_1376"/>
    <dbReference type="OrthoDB" id="8588at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF20">
        <property type="entry name" value="P-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="880" mass="96598" checksum="5309EE18797E790B" modified="2017-06-07" version="1">MGKETFNHEIEDVENILKSLGVDVENGLTESEATRRIQSYGLNAIPEAKKHGILQIFLDQLKEPLILVLVVIGIIYFLIGTPFESFTVIIIVFAVILIEVYNVKKAQISIQALHSMVTPKTWVLRNGSLLEKSTSVLVPGDIVYLRTGDMVPADGIVVSSSGLYIDESLVTGESYPVNKVSYDVAETQPGANMHRVVSGTLVVQGNGKFAVTSTGLKTEIGKISESVKNHKEIPTPLEKSLNKTARLLIVIAVFFSALIPLIGYVHGDPLDQMILMGLSMAFATVPEEIPILITITLAIGAYSLSKKKAIVKGLTAAQTLGSVTVIATDKTGTITENAMKVNHILTGGKLYEAAQGTNSSFLKSAVLATGNLEIEQKFSEGYKDPMEVAILKYAINSGLDIHELESEYQITGRFGFDSNIKRASYVYSVHDGYVAYTSGAPEVVLSRCTKVMVDESSNKVKSEDDLKLIRDAINEVAKVGERTIAFAYKRINGQAEERDIVDSDMIFIGMISFIDPPGKGVKNAVKLCQNAGIRVIMLTGDYPVTAETIGKMVGIENAESTLTGDQIRAMPDDELSKAIEKTSIFARITHDQKLRIVKALQKNGEIVAVTGDGANDASALRAAEIGISMGKRGTEVAKEASDIVLEDDNFHTIAEAVFEGRKMQYTLKKGIRYYIAVKISLILILLVPILLIIPFPFMPIQIIIMEMFMDVGALWGFLKERDEPGILHAAPQKRGADFMDRPMIISILTSALGVFLAVTFIYLYIYYSEADIIQAQTAAFATWILSQVILAQNLRTEREPVSQRSFFSNWVILSWGLIVVGALIVITIFTPLHAIIDTSTIEYRNWVLIIIVSVLSSSWIELRKIIISKKKKNPPQPLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N589</accession>
    <name>A0A1V0N589_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Imidazoleglycerol-phosphate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="4" type="ORF">FAD_1452</name>
        <name evidence="5" type="ORF">HLB00_01375</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000038">
        <property type="protein sequence ID" value="NOL59488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142915.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N589"/>
    <dbReference type="STRING" id="74969.FAD_1452"/>
    <dbReference type="GeneID" id="84218044"/>
    <dbReference type="KEGG" id="fai:FAD_1452"/>
    <dbReference type="OrthoDB" id="103579at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="176" mass="20027" checksum="E8040BF361C268B3" modified="2017-06-07" version="1">MIRETKETVIEVDIGSESTIIETGDKILDHMMRTLFFYMGRNAKIKCSYDLRHHLWEDLGITIAMELTALKGEKPVKRFGSATMPMDESLIMVSLDISRAYINFQVDFRDAEGFELNLLYEFLWALARTMPMTLHVIKFSGTNSHHITENVFKALGVALGNALEGTEYTRSTKGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5B1</accession>
    <name>A0A1V0N5B1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="6">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ImGP synthase subunit HisF</fullName>
            <shortName evidence="6">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hisF</name>
        <name evidence="8" type="ORF">FAD_1449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142912.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5B1"/>
    <dbReference type="STRING" id="74969.FAD_1449"/>
    <dbReference type="GeneID" id="31676942"/>
    <dbReference type="KEGG" id="fai:FAD_1449"/>
    <dbReference type="OrthoDB" id="6261at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="250" mass="26817" checksum="834450920FB17739" modified="2017-06-07" version="1">MLAKRIIGALDIAGDRVVKGVNFENVRDSGDPIQLAKRYESEGIDELVFLDIRATREKRNIMNMLVERVASEVYIPFTVGGGLTDIETMVKIIRNGADRIFINTYAVEHPEIIGEISDRIGSANTVIAIDSGRHNGNYYVYTHGGTLNAGVDAISWAQKAESLGAGELLVTSINTDGTKKGFDTELIEKITGSVNIPVIASGGAGSPADFLGAFQAGADGALAASIFHEGKYTANEIKKYLKENGVNVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5B6</accession>
    <name>A0A1V0N5B6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951142.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5B6"/>
    <dbReference type="STRING" id="74969.FAD_1436"/>
    <dbReference type="GeneID" id="84218028"/>
    <dbReference type="KEGG" id="fai:FAD_1436"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="290" mass="33251" checksum="49C38D6D82D011E5" modified="2017-06-07" version="1">MPYIKKHFKIFIAILIVIILISSFIVYDITRNNVTYNNNGEPIDVKYFSVGYTFPYITNNYTASSYYVNHNKLSYMNSTIIQPRVLPYGYGCICFGINIHLKNVNNKYIYVDIISQAEPSTFNPSLNNATEIHSSYISGVCHVKYRINGNNISIPSITIRNIDKYIHNNYYNISVSISLNNNFYNTFDISGIKETAIYGSVGQSNTSQVRDPNLTSSLYIENNNTHNFHIVSIRDGYFYFFAQPDTTYKLYYMDNGKLHEFYHISNNKITGLNSITTSSAGNSTPLNIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5B8</accession>
    <name>A0A1V0N5B8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">psmB</name>
        <name evidence="11" type="ORF">FAD_1472</name>
        <name evidence="12" type="ORF">HLB00_02140</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000062">
        <property type="protein sequence ID" value="NOL59633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886578.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5B8"/>
    <dbReference type="STRING" id="74969.FAD_1472"/>
    <dbReference type="GeneID" id="16024703"/>
    <dbReference type="GeneID" id="84218066"/>
    <dbReference type="KEGG" id="fai:FAD_1472"/>
    <dbReference type="OrthoDB" id="6330at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000049">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5044508781" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044508782" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="8"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL59633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="210" mass="23035" checksum="A1CD52151E036CB2" modified="2017-06-07" version="1">MEVLKTGTTTLGITAGDYVIMGTDSRATMGNFISNKNAQKLYKIDTYAGMTIAGLVGDAQVLVRYMRAEMELYRVQRKINMPIEAAATLLSNMLNQSKYYPYMVQLLVGGFDKKPHIFSIDAAGGSVEDEYASTGSGSPFVYGVLEAEYQPNMKLDDAINLAIKAISVAKQRDSASGNMLQIGVIDPEKGFNYLSEDDILSRMKKLKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5E0</accession>
    <name>A0A1V0N5E0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886574.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5E0"/>
    <dbReference type="STRING" id="74969.FAD_1469"/>
    <dbReference type="GeneID" id="16024699"/>
    <dbReference type="KEGG" id="fai:FAD_1469"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="95" mass="10887" checksum="65DF4077EAA51C28" modified="2017-06-07" version="1">MFKITVRYNSTIPVCDQIYSGMIDEIRSGNLYYKTKIPSTEQVAGVLGLNLNAVDRAYGLLLKDRVIRQFKNKKYVMAPGDTDINPMIKKRSRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5J3</accession>
    <name>A0A1V0N5J3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA double-strand break repair protein Mre11</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mre11</name>
        <name evidence="11" type="ORF">FAD_1564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Nuclease activity is regulated by Rad50.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142954.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5J3"/>
    <dbReference type="STRING" id="74969.FAD_1564"/>
    <dbReference type="GeneID" id="31677055"/>
    <dbReference type="KEGG" id="fai:FAD_1564"/>
    <dbReference type="OrthoDB" id="11638at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02044">
        <property type="entry name" value="Mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050535">
        <property type="entry name" value="DNA_Repair-Maintenance_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032885">
        <property type="entry name" value="Mre11_archaea-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337">
        <property type="entry name" value="COMPONENT OF ATP-DEPENDENT DSDNA EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337:SF0">
        <property type="entry name" value="NUCLEASE SBCCD SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="10">
        <location>
            <begin position="3"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="373" mass="43039" checksum="96F862A18D62F15C" modified="2017-06-07" version="1">MARFLHLSDTHLGYRQYMMDLREEDFYESFNEAIDFGLEENVDFFVHTGDLFDTWSPSNRAMNEFKKAMIKLYKKNKTMYLIMGDHDRPKRTDEVASRIFDFLGVKLLGTEELQSIVINYGGEDILLSGISNMKGLRKNNLVEQYRKADVEAKSYKNSIMMSHQGVSPYLIPEACEVDSKDLPVNYKYLAFGHVHDSYLITDKYPVFSYAGSTDLNSTNEIKNFLRNGKSVNLVDIENGKIDAQRVKLKSTRYLNAVNTNYASYMDDMQKILKTPGINGKEPLISLTIHGDADRDDVKANLLLLKNVIIRGPVFEKEVKSIEEKPNMSKLQDYFKAYFKDDQMASLAENIFNSIKNEDNETSYRLIREIMQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5K6</accession>
    <name>A0A1V0N5K6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1548</name>
        <name evidence="3" type="ORF">HLB00_00925</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841460.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5K6"/>
    <dbReference type="GeneID" id="16024817"/>
    <dbReference type="GeneID" id="31677039"/>
    <dbReference type="KEGG" id="fai:FAD_1548"/>
    <dbReference type="OrthoDB" id="385557at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="271" mass="29976" checksum="B87FA5834B360C74" modified="2017-06-07" version="1">MVKRENRKIMVALLLATIMMMSGFMGLIYFNHENNTVDKTHIPELNYYLNKYDFKDFHNVSHTKVFNNANDVNAVTDVSNNTVLTMSYTFYNGTDNVTGELLHIYKNGQLFHESLLVNNTHGNNYNYSVIPLYSKSGNYNITILNHNVNKASVKGISSDVYIDLYATRSTGPSGWACAFSESNTEVLITYIGAIGALSGIGSMGALAAIAVIGAATIAFFDEEGGNNGVYFYEAHAWFVPYTWINAPASAVPNSYNEYGSHRVTLYEGNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5K8</accession>
    <name>A0A1V0N5K8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bipolar DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">herA</name>
        <name evidence="8" type="ORF">FAD_1565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HerA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5K8"/>
    <dbReference type="STRING" id="74969.FAD_1565"/>
    <dbReference type="KEGG" id="fai:FAD_1565"/>
    <dbReference type="OrthoDB" id="107033at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018538">
        <property type="entry name" value="HerA_barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09378">
        <property type="entry name" value="HAS-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase HerA barrel" evidence="7">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase HerA central" evidence="6">
        <location>
            <begin position="137"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="517" mass="58032" checksum="D4E0AD136012D505" modified="2017-06-07" version="1">MKQGVKGVQESELKIGYTIGENTSGRFQFVISDDSDIKKWEYVYLKIKNEIVIGRIEEIKSKSELMNDGMDYQSIDKYAKTGMNDFVNICISTILGKLKDGYLAQSREIVKPGMPVYPASDEILQKVFSFNMEESLNIGSLPDNNVNVSLNVNGLRRHLAILAQTGAGKSHTASVIMEELLKKGASIIVLDPHADYVFMKKGVDGKFYSEGISVFRTPLSTGRYTNNDVGIINNFTIRFSDLTPDDVKGIMDIKEGYTNLISIVDDIYKKMKGKKDLNDFLETAESLPAEDYKKIRGRLTFLKKIKDIFQDYTTGINDYLGPGKMSVMDLSGMDQFLANYFSYRVLSSIYDVKLSSEFKYPVFVFIEEAHNFVPPRSNSNIAKMIKKIAGEGRKFGIFLVVITQRPGKIDADVLSQCNSQIILRVTNPSDQNAILESSENITGYLMEDLPSLDTGEAIIVGEIVKMPAIVKIRNRETMAGGSDIDVITLLREAREEVRKKNDPSEIRKKTKDLLGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5P7</accession>
    <name>A0A1V0N5P7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S2P/M50-2 group multipass membrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795595.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5P7"/>
    <dbReference type="STRING" id="74969.FAD_1567"/>
    <dbReference type="GeneID" id="31677058"/>
    <dbReference type="KEGG" id="fai:FAD_1567"/>
    <dbReference type="OrthoDB" id="19110at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06160">
        <property type="entry name" value="S2P-M50_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412:SF0">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="9">
        <location>
            <begin position="131"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="359" mass="40331" checksum="66BD8E751579B78C" modified="2017-06-07" version="1">MFQSVRVENENMDKVIDIVKSKINTYEVLANPASMKFLFFDSDNPDINTQFDELRKILVPMGYIPFLVLDVEHYVEVGIRPKASYRSNKVNLIMLILTLASTIYVGSIYASSFVHPGTFAEEYKLLYGFVFFSLPLMFILGIHETAHYIVARRYKVNASLPFFIPFPYLIGTFGAFVSLRDPVPTRKAMAEIGAAGPIAGFLAAVPLLFLAQYLEGIFKPIGNYIPFILNYPEIYHIFGIVEPSNVPIFPMVFAVWVGMFATAMNLIPAGQLDGGHIARGILGPRSYILGYIFIGFLFYLTITYHYIGWLFLALFVIFMGMAHPPALNDCEKISRVDIGIAVFCLVMFALTFTALPIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5R1</accession>
    <name>A0A1V0N5R1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="11">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">miaB</name>
        <name evidence="15" type="ORF">FAD_1628</name>
        <name evidence="16" type="ORF">HLB00_02450</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Berkeley</strain>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000075">
        <property type="protein sequence ID" value="NOL59694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886760.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5R1"/>
    <dbReference type="STRING" id="74969.FAD_1628"/>
    <dbReference type="GeneID" id="16024895"/>
    <dbReference type="KEGG" id="fai:FAD_1628"/>
    <dbReference type="OrthoDB" id="372134at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="111"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="343"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="NOL59694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="400" mass="45630" checksum="391080DFE46D1D9D" modified="2017-06-07" version="1">MKIYFESYGCTLQKSESSLYLNKLLKDENNQIVNSPEEADLSLIGTCVVIKHTEDRMVKRISSLSKVSGNVQVLGCLATVNGNTIESGNVQVLKPREFRSFYEGDLDGIEIKSDIYDGIPINQGCTGSCNFCISHIARGKLLSRGIDKIVNQVNMELDRNIKEIRISSLDTAAYGKDIGTDLAELVNRISSIDRDFYLRVGMLEPRNTYDILDKLVDAYRHDRVFKFLHLPVQSAENNVLSAMNREYTIEEAEAVWQKFHDAFPDMSIATDIILGYYNDSRAGFEKTMKFLEKYNPDIINVTRFSPRPYTKDYNKTPLNSNLLKEWSNEIISLHREQMEKKLDSYLGREEKVLITEKGKNGTMVGRDINYRPVVLKGNYEKYSEIKCTIVSHGSNYLIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5T7</accession>
    <name>A0A1V0N5T7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1601</name>
        <name evidence="9" type="ORF">HLB00_01585</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000042">
        <property type="protein sequence ID" value="NOL59528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142980.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5T7"/>
    <dbReference type="STRING" id="74969.FAD_1601"/>
    <dbReference type="GeneID" id="84218196"/>
    <dbReference type="KEGG" id="fai:FAD_1601"/>
    <dbReference type="OrthoDB" id="8615at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054016">
        <property type="entry name" value="FKBP26_IF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048261">
        <property type="entry name" value="SlpA/SlyD-like_ins_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47861">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47861:SF2">
        <property type="entry name" value="LONG-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22199">
        <property type="entry name" value="FKBP26_IF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="FKBP26 IF" evidence="7">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="257" mass="29822" checksum="D23CA7A5262B1A17" modified="2017-06-07" version="1">MNDGDFIELSFEMRAGQDKKLISTSKEDLAKQENIFDDKKKYKNAVIVIGTDGLFKEINDSFKQAELGKEYEVTVPAKDAYGMRDTKNIKVVPMREFQRNKINPEIGKEVNINNKVGRIISVTPGRVLIDYNHELAGKDLYYKYQISKVIDDVKGKVNAIIDMDYSDSDNFVVEIENDSISIQIPEEAKFDVNWIDSKYKIVNDIRKYMPEKDVVVKELYKKEEKKEEKKEEAPAENKEEKKEDSKENQKDNVKETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5U2</accession>
    <name>A0A1V0N5U2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">External membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5U2"/>
    <dbReference type="STRING" id="74969.FAD_1677"/>
    <dbReference type="KEGG" id="fai:FAD_1677"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058349">
        <property type="entry name" value="DUF8036"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26119">
        <property type="entry name" value="DUF8036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="94" mass="10997" checksum="3F1D8CD70CF83ACB" modified="2017-06-07" version="1">MEYIWITNMVIIAIEFIIFLIIGISYIKNYKKTGLKVYNQIFVFLFVFMVQSAMTLYIYYNFSKFLGLNVSLPLLIINITGLTGTVLLYKFISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Y0</accession>
    <name>A0A1V0N5Y0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143051.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Y0"/>
    <dbReference type="STRING" id="74969.FAD_1718"/>
    <dbReference type="GeneID" id="31677209"/>
    <dbReference type="KEGG" id="fai:FAD_1718"/>
    <dbReference type="OrthoDB" id="30676at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="471" mass="54422" checksum="FBACBA9607AF2006" modified="2017-06-07" version="1">MYIDNVISFDSIEVNIASIEKKRIIGNIKFDDFSYRLIFTYAEDIDVDRNIAGLILTMPAINFTYFARKLVLNFPVSPTDIELIKNFMKINAHEVFINKIINRRYDYIKPEFIPAEDDITAANADGITELVCPETFSEERPWNTSPDKVAIMSSGGKESLLAFGIFNEINKPENNYSFYFEESGSHWLTAKTAYDYYKENFGNVMKVWSNTDRFYHEMLNHIKIVNTDMIDILSDDYPIQVFIFPVYIFLLLPLLKKYSIGNIIMGDEFDDPREMGDYKGLKYYYGIFDQTYDFNHMLSLYFNKKGVNAGVYSIVYPVTGYLEEKILMERYRDLFLQQRSCHSCHRKDGVIEPCGKCSKCLGILLFIEASGGKPEDILYSSDDVRLLKRRLSKARLRLDPDERIYAESKIGLYSGSIGDAEHAGGLHIMPYENSLFSVIPDNFRSPIEKIFSAYAEGIFKLDNGKWVNIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Z4</accession>
    <name>A0A1V0N5Z4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143014.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Z4"/>
    <dbReference type="GeneID" id="84218268"/>
    <dbReference type="KEGG" id="fai:FAD_1671"/>
    <dbReference type="OrthoDB" id="387004at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="121" mass="12775" checksum="A72FBCCEA3964ECE" modified="2017-06-07" version="1">MASNARIRYLITSIGSIITFISGIIVLLLLFISGLGGAAQLLFFNPAGAAVIGSSIVMAIVPIIWIILAYIIYTRADGGRRKDKVLNGVIIIFLGFIILLLGGGFVIGPVMEIVGGFLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Z7</accession>
    <name>A0A1V0N5Z7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(FAD)-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1731</name>
        <name evidence="2" type="ORF">HLB00_00210</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000007">
        <property type="protein sequence ID" value="NOL59261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143063.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Z7"/>
    <dbReference type="STRING" id="74969.FAD_1731"/>
    <dbReference type="GeneID" id="84218352"/>
    <dbReference type="KEGG" id="fai:FAD_1731"/>
    <dbReference type="OrthoDB" id="57506at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052541">
        <property type="entry name" value="SQRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43755:SF1">
        <property type="entry name" value="FAD-DEPENDENT PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="288" mass="32472" checksum="E4FB87C23C564A86" modified="2017-06-07" version="1">MEKYSVLILGGGYGGINAYYGIRDKSHVAIIDSKRNSVYHGKSRDIGMNIPASIMESIKKVDIEEPYVQTDRHEYYPEKLVISTGCNRESQIEFMSKSHLYNNMYLGSKNEYDDYILIQYILKLNKAGIHAGYSGNFLSFLGKEVKIKVRKFLALSGVPLSPDADFLLPECSPNIFGNYINVDKNLMVNENTYAIGDALDWNAKCGELSMRQGAFAGRHMSGKVHDFKPVFITILDNLKGTGIRIKSTEPWNSGIASAHIGREYSLMAGFLMHYYGFRNGNMGFLQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N610</accession>
    <name>A0A1V0N610_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator (SlyA-related)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886891.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N610"/>
    <dbReference type="STRING" id="74969.FAD_1749"/>
    <dbReference type="GeneID" id="16025024"/>
    <dbReference type="GeneID" id="31677240"/>
    <dbReference type="KEGG" id="fai:FAD_1749"/>
    <dbReference type="OrthoDB" id="57427at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039422">
        <property type="entry name" value="MarR/SlyA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33164:SF43">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REPRESSOR YETL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33164">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="141" mass="15995" checksum="C183689F62187060" modified="2017-06-07" version="1">MDNALNIWSLFDSILGEYAVRIKSHLSSLSLSMVDYKILHLVHSEPKNMKYLADTLSLAKGWVTDITDGLEERNLVKRVHSSQDRRVINIEITDEGLKIYNKVGKMIKTIIGDSISSLPEDDVEKLSTILEKISQNMHCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N650</accession>
    <name>A0A1V0N650_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143093.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N650"/>
    <dbReference type="STRING" id="74969.FAD_1791"/>
    <dbReference type="GeneID" id="31677281"/>
    <dbReference type="KEGG" id="fai:FAD_1791"/>
    <dbReference type="OrthoDB" id="200998at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050189">
        <property type="entry name" value="MFS_Efflux_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124:SF3">
        <property type="entry name" value="CHLORAMPHENICOL EFFLUX PUMP RV0191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124">
        <property type="entry name" value="PURINE EFFLUX PUMP PBUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="389" mass="42707" checksum="86AC702E468100FF" modified="2017-06-07" version="1">MNYGTRAGLVHTARALYALNWMDMAPALEYIKTDMNLTVVELGTLVTAFYVGIAVFQVLGGYLSSYIGDKTTSLIGLLFVSIFAITSGLSVNFTELIVSRFFAGLSAALFFSPALSLLASIVPENKYAFHIGIYNGAFNVGGGVGIIGWAILDQYMGYRIPFIIAGVLTLALFFVLVFLFRNIENIKTNKSDIFASFKKVFSNRIIILVAFIGIAAMVAETILGQFFVYYLESIKYSVDLAGSISSLYLLIGFLGGVLGGYHFSRTKYKIGTFLAINIVLSILLILIGFIHYYIFIIIIAIAMGMITVYGMSITYTLVRYLARRDLVSLTLSFVNTLQLLVAVAVPVIFTIIVSQYNYELAWVSMGILGLIFVPLIFLAKGNLIKVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N651</accession>
    <name>A0A1V0N651_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1716</name>
        <name evidence="3" type="ORF">HLB00_00125</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000005">
        <property type="protein sequence ID" value="NOL59245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143049.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N651"/>
    <dbReference type="STRING" id="74969.FAD_1716"/>
    <dbReference type="GeneID" id="84218336"/>
    <dbReference type="KEGG" id="fai:FAD_1716"/>
    <dbReference type="OrthoDB" id="6371at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004996">
        <property type="entry name" value="PRK06381.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="12"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="311" mass="34492" checksum="57F9F357B5EA8371" modified="2017-06-07" version="1">MEIETEDKPPGSPLIRDSDIGNYLERSNFFIKYEGVNPTGTQKDRISRKHVENAIKHGYKEISVATCGNFGASIAYYARGMGIKAIVGIPAEYSNSRHAEIAAYGADIIEKPLKYEEMVEYIRGEAKKNNWYDASPGSPNKSIDVSGYSEISFEIYNQLGFAPEYISIPVGNGTTFYGIYYGFLKLYRERKIDKMPKFIATSTEGGNPIVYSFINGFRNIVELDPENIVETYANEPLIAYRSYDGQKALDALYKTHGKALYVSDMEMEEISRGFKRIDNLSVLPASASAAAGALKFAGNNSCVIVLTGSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N669</accession>
    <name>A0A1V0N669_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2249 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143067.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N669"/>
    <dbReference type="STRING" id="74969.FAD_1740"/>
    <dbReference type="GeneID" id="31677231"/>
    <dbReference type="KEGG" id="fai:FAD_1740"/>
    <dbReference type="OrthoDB" id="186771at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018720">
        <property type="entry name" value="DUF2249"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37694">
        <property type="entry name" value="SLR8022 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37694:SF1">
        <property type="entry name" value="SLR8022 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10006">
        <property type="entry name" value="DUF2249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2249" evidence="1">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="210" mass="23729" checksum="6EC59A63F97D1FA6" modified="2017-06-07" version="1">MGNIKNNYIEIDIRNIAPGERRSKIFERFLALGQGQELHVIADHDPVHLLGSMKSHKLPVDVAAYRTLTDKDGTFTGIFKKLEHENVNENFLATDIDQERNYLPDRFNPVTVYTGENYRVIITYIKAGQFIPVHSPSTDLIFSVFKGNGSMVAGDREINIHPGSIVIVHAGEKRGVFANTDMEAFHVVSPVPDEKDHLEVKEKLESKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N685</accession>
    <name>A0A1V0N685_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="11">IPP isomerase</shortName>
            <ecNumber evidence="11">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="11">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">fni</name>
        <name evidence="13" type="ORF">FAD_1829</name>
        <name evidence="14" type="ORF">HLB00_09760</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Berkeley</strain>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000435">
        <property type="protein sequence ID" value="NOL61102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886979.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N685"/>
    <dbReference type="STRING" id="74969.FAD_1829"/>
    <dbReference type="GeneID" id="16025109"/>
    <dbReference type="GeneID" id="84218453"/>
    <dbReference type="KEGG" id="fai:FAD_1829"/>
    <dbReference type="OrthoDB" id="371955at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665:SF1">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN-dependent dehydrogenase" evidence="12">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="FMN-dependent dehydrogenase" evidence="12">
        <location>
            <begin position="196"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="5"/>
            <end position="6"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="290"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD85668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="NOL61102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="349" mass="38866" checksum="DE063676B2C698C0" modified="2017-06-07" version="1">MIENRKEEHINIAENMNVTSEHNFWDDIRLIHRAIPEVDYDSINTKINFLGTEFGLPFLISSMTGGTEKARKINENLARAAEEFKIGMGVGSMRAAIENKNIADTFSVINNYKIPARFANIGAPQLIGQEKPPISDKDIEYIFNLIGAKYLIVHFNFLQEMVQPEGDKNARGVMSRLKEIAKSYPVIAKETGSGFSRDDALELKDAGVKAIDVGGLGGTSFAAIEYYRAEKIQNKEKMHTGQTFWNWGVPSPASIKFCSVGLPIIGSGGIRNGQDVVKSIIMGADMGAMARNFLKDADTSYEDLVFHIKNIIKDIKISMFLTASKDVSELKNKRYIVLDPLYSWLNQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N689</accession>
    <name>A0A1V0N689_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prf1</name>
        <name evidence="11" type="ORF">FAD_1803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841537.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N689"/>
    <dbReference type="STRING" id="74969.FAD_1803"/>
    <dbReference type="GeneID" id="16025082"/>
    <dbReference type="GeneID" id="84218426"/>
    <dbReference type="KEGG" id="fai:FAD_1803"/>
    <dbReference type="OrthoDB" id="1011at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000003">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000003">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00424">
        <property type="entry name" value="Rel_fact_arch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020918">
        <property type="entry name" value="Peptide_chain-rel_aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="412" mass="47305" checksum="E68BBECD3385336C" modified="2017-06-07" version="1">MDDEDYKRYEFKKAMEELSKLHGRGTELISLYIPPDKQISDVVQYLREEFSTSSNIKSKTTRKNVLGAIESIMSRLKYYKQPPEHGLVFFVGHVATRGDQTEMYTKIIEPPQAIQTFLYKCDSSFHLEQLTDQLKEKELYGLIVIDRKEATIGFLRGTKIDVVDYEYSLVPSKHRQGGQSSRRFERLIEIAANEFFKKIGDIANSTFMPVIKDVITIFVGGPGATKEYFIEKDYLRNEIKDKIKDLFDIGYTDESGLRELVEKASESIKDMRITREKDIINRFLREIKKSDGGLGVYGEASIINALKMKNIELLIVSDSIRKIKYFYKCPVCGAEKTFTDEPTEEPVCDNDNTPMNFEKEDDFIEDLYKMAEESGTKVEMVSEDSDEGRLLKTAFGGLAGILRYVPENQLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6B3</accession>
    <name>A0A1V0N6B3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">8-oxoguanine DNA glycosylase/AP lyase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">8-oxoguanine DNA glycosylase</fullName>
                <shortName evidence="7">8-oxoG DNA glycosylase</shortName>
                <ecNumber evidence="7">3.2.2.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">DNA-(apurinic or apyrimidinic site) lyase</fullName>
                <shortName evidence="7">AP lyase</shortName>
                <ecNumber evidence="7">4.2.99.18</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">ogg</name>
        <name evidence="9" type="ORF">FAD_1812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type-2 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="7"/>
    <dbReference type="EC" id="4.2.99.18" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886961.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6B3"/>
    <dbReference type="STRING" id="74969.FAD_1812"/>
    <dbReference type="GeneID" id="16025091"/>
    <dbReference type="GeneID" id="31677302"/>
    <dbReference type="KEGG" id="fai:FAD_1812"/>
    <dbReference type="OrthoDB" id="35941at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00241">
        <property type="entry name" value="Ogg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012092">
        <property type="entry name" value="DNA_glyclase/AP_lyase_Ogg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002305">
        <property type="entry name" value="PRK01229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22175">
        <property type="entry name" value="Ogg-HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005954">
        <property type="entry name" value="Thrmst_ogg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="8">
        <location>
            <begin position="49"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="site" description="Important for guanine/8-oxoguanine distinction" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="209" mass="24659" checksum="9DF2E24487C0E33C" modified="2017-06-07" version="1">MIKNDELSIKIMESKLLYSKKINERVIDFINMGKSRNDSLFMELCFCILTANTSAEMGIRTQRMIMDGFIEYSMEQLSEELKKAKYRFYNKRAGYIINARFIRKNIKKLISSMEHFTLREYLVNNVKGLGYKEASHFLRNIGIFDFAILDKHILQLLFDYGYTKDMKLNSRADYLEKEKIFNSIASDYNIQPGIMDLYLWQIATGKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6H1</accession>
    <name>A0A1V0N6H1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MoaD/ThiS family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1843</name>
        <name evidence="2" type="ORF">HLB00_06870</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000246">
        <property type="protein sequence ID" value="NOL60553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886990.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6H1"/>
    <dbReference type="STRING" id="74969.FAD_1843"/>
    <dbReference type="GeneID" id="16025124"/>
    <dbReference type="KEGG" id="fai:FAD_1843"/>
    <dbReference type="OrthoDB" id="57434at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7067" checksum="C0D9FAF43C4C1082" modified="2017-06-07" version="1">MIEIIGKEKRKIHIEESKKLSDIYSAFNIDEDGFVAILNGNPATSDAIVNPEDNLVFLEIFSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1L8</accession>
    <name>A0A1V0N1L8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="2 9">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_0080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="2 9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1L8"/>
    <dbReference type="STRING" id="74969.FAD_0080"/>
    <dbReference type="KEGG" id="fai:FAD_0080"/>
    <dbReference type="OrthoDB" id="94124at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010386">
        <property type="entry name" value="PRK13813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="7">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="7">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="227" mass="24959" checksum="B7A8C0DDD612E487" modified="2017-06-07" version="1">MPALAYLLYMHNKYTTMESKIIFALDVYDYNTAVDLARTVGEKVFAIKINWPVILENGIKIVRDLSKYANIICDFKLADIDNTVSMITTKVKEYGGYGIISHSFTGLNSLKAVVKSAGNMKVFSVVSMSQESYLDNITEELIKISMEAGVYGLVAPGNRPYYLKKVKELSEGLKIISPGVGAQGGDIVNAMLLGSDYVIIGRSIYNSPDPLETLEGFSSSINNKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Q1</accession>
    <name>A0A1V0N1Q1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase polypeptide I/III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141379.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Q1"/>
    <dbReference type="STRING" id="74969.FAD_0152"/>
    <dbReference type="GeneID" id="31675663"/>
    <dbReference type="KEGG" id="fai:FAD_0152"/>
    <dbReference type="OrthoDB" id="56522at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="814"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="7">
        <location>
            <begin position="17"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="835" mass="93323" checksum="FB9ECAED8B942267" modified="2017-06-07" version="1">MEAESNDQIYERNNKIYNSVRGWIFTTNHKQVGLLYILTSLVFFIGGGVLALLMRVQLAIPRYDLVHYGLFSGRFLDALQYNQLVTIHGLTMLIWFLGPLGFGFGIYLVPLALGSRDMIFPRINALGYWLYLFSGILLWIGFFLPGGNLDTGWTVYQPLSSFKFTPYLGADTAAAAVVVRSLGTIIASSEVIATVFKARARGFRLMNMPLFVWAVLWVSMISWYVFPEIGAMFFTLVVSNVLGLSGFISTYGGALMWENLFWYFGHPEVYLLLLPGTGAMFDYLSNLGHRAPYLKKWMIAAMGAISVDSVMVFLHHTFMTGIVFAWLMATSVFTETISIPTGMLIVGLIATLLGAKHKFQTPILFALAASTSFMIGGITGVTQSSLAIDTIVHGDYYVVAHFHYFMVGVAVMGLMGNLYYYFPKFTGKMYSETWGRIHWAIAYIGVNVLYFPMFFLYDLPRRVYTYPAGYGYTIFSEISTAGAFIFGLSFLIMFANFAYSMKKHAPLTDQNSYKATAGFVWFTSNPPKYYNFDYEPYVGGEDHRDLLLDKNNPIKPPKVELSTRPLLIGVGVVLAFIGAAVTLMGYKPYAFGPAYAYLGYGIIAFAAAIFLWGTIGWMYDDFKLRSPNVPPMYKKEPVMKGFNNTRLGMLMFLAGNMIWMATFYGMVEWLKLQSASPYVDGNDPTTWFFPTMATVYIVISIVAIGIAALLAWGSTYGAIRKERNKSANYMTAGVVLAVISLITSLLSLIVINSYPALRYGAATANNPIASMYWLISLMDLLFSIGVIAVMINYVVHLKRGKKILWGRTATRADVVMWFVAFVFLTGIFTTIAFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1R0</accession>
    <name>A0A1V0N1R0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type peptide transport system, solute-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1R0"/>
    <dbReference type="STRING" id="74969.FAD_0091"/>
    <dbReference type="KEGG" id="fai:FAD_0091"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290:SF10">
        <property type="entry name" value="PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 5" evidence="6">
        <location>
            <begin position="302"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="787" mass="87142" checksum="46F461000274EF0C" modified="2017-06-07" version="1">MKSSMPDPETYPKKPRSTRKKWYAVIIVLVLIISSLGVLSLLHPESKSPDISVDTAPNYLKTGSNYTISLKANEPYKTLTIFWGDGNSTALNYTQETVSVSHMYDSPGIYYIYYIANFTSGPEEFNTYIPVYVESAGTGNRTAEGTLTILKSSISPVVANSNIYSNNTTIGMNISNAGNPSNSTFTIVNQTLYVYKNGGLNKTLSPGNNDTLTVNTGYYMLKLSTITGNKAGTNYTTYYYMDIPVNPAAKLYINTVNNSIVMDSLTPYANLNPQEAYTTSELEILGNIEETLVGNGSSGYFPEIAASLPSPHGKSYTFNISSKAKFSTGQPVTAYDVYYSLVMDLLLENKEPQTPGWLLAQYLLPGNYHSTDNYTNIKNAIAYNNSTQTVTLNFTAKLQPDTVFSILSSPGTFISSYSYLVQNGENLTLSPAGVRAFENSNKTYAMSGAISDGPYMILSSVPGEYITMVRNPFFIGNANNSVPTINSVTIDYISQYSSIYQDLRFNTSQLAIFPDTYPYTSYLTTVKPYNNSYNVSTIYDFNANVNKTILGKYTDQVNFPANLFSNITVREAFMEAYPGNNLTSAEALWKSFISNTTTSSRFHIDPSGKYNNKPLEIPIFAMPLVSGPNLSQFAANLKEMTNNSSSFSIVTEPVSFFNEYTYSGLNPMPIYETITAENMNLSAYYSYLGSTMNYTHAYNNGFSNYSFAASHMNQSIIMSQLNSNISSLVMNYNQTNLNKTKSLMNSLYLYINTSRSINTKLYLQNYITAGNGTFDSQGIVIFNRLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1S2</accession>
    <name>A0A1V0N1S2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141344.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1S2"/>
    <dbReference type="STRING" id="74969.FAD_0108"/>
    <dbReference type="GeneID" id="31675620"/>
    <dbReference type="KEGG" id="fai:FAD_0108"/>
    <dbReference type="OrthoDB" id="57101at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="226" mass="26114" checksum="FB5413F840DA476E" modified="2017-06-07" version="1">MANPGQNPRQNPKKNEEPLFEEPKFDKRQYLTYERERAKAIISVFITGALIGLLSGELEIYGYWYISIILIIVVIYFLRSIITLFKIAIPKQTTHKLLMYLELIITWLVFWIIALNPPLHVVSGPEVIDLEYMHNGNWTKLSETDKQYELLGGHSFQLRYFTNYKYNITGITIQEHGKLINNTYDRSTGYVSFNLTAPTAKSTESINITENSRVTTHETITFLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1U8</accession>
    <name>A0A1V0N1U8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1U8"/>
    <dbReference type="STRING" id="74969.FAD_0147"/>
    <dbReference type="KEGG" id="fai:FAD_0147"/>
    <dbReference type="OrthoDB" id="57534at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="58759" checksum="68D705F89E15E84D" modified="2017-06-07" version="1">MKREIVESLIISVFTLYLFIYSAITGVFVVYNTRLYPSIYQFLAFLLPYVVLPLLVFFRKNSVINRIYLYFLFIGLFSFIVLLFTYIVYPLMEIMVLLTIAFYTDIIDNLYYKENKPLFYRGATFVLILFVMLLVSRFFVISVPVEPTKIVVDSIYADFSHSQVPFLFYYGIIMRVNYIDFTMGIQSIILYLILAALLTENYFLIFSIVNINGGISRKKSNGRRGASAMVTPAISGAVSALSCQCEGLTAILPTIAAVVASAISTALLSESILLLLISNFMLTVFFNRRARVKLISHIKDLRNSNYFPLLAIFFVMLIPIMEVIGIFYHLQLTSLTFFYGVNILMFVSGIFLMYAITKIGMKPFIKTVKIKAILAAIASILMFIWFIPPIAYFAYTNYYYYFLMNIMGVISGLLTYLVYFNIAKFKAAYIEFNSMMFSMTALVLFYISIISLDDLFPFYGIKQQLYFSAILWGITLPFMWLSTIETMYRHSIVDTPILQKAHHQGKAIHAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N229</accession>
    <name>A0A1V0N229_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps4</name>
        <name evidence="11" type="ORF">FAD_0261</name>
        <name evidence="12" type="ORF">HLB00_03150</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000099">
        <property type="protein sequence ID" value="NOL59830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141430.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N229"/>
    <dbReference type="STRING" id="74969.FAD_0261"/>
    <dbReference type="GeneID" id="31675770"/>
    <dbReference type="KEGG" id="fai:FAD_0261"/>
    <dbReference type="OrthoDB" id="10429at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_A">
        <property type="entry name" value="Ribosomal_uS4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022802">
        <property type="entry name" value="Ribosomal_uS4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="106"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL59830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="195" mass="22462" checksum="31AB8B26B1728BB4" modified="2017-06-07" version="1">MGDQKFQRKRYSTPRHPWEKERIDSERQVVAKYGLKNKRELWKAEAILSSYRAQARTLQAKVRYNDPIAEKQFQLLLKKLDKLSLLSEGATLDDILALNIENILDRRLQTLVYQLNMATTMKQARQLITHGHIKVGDHIVTIPSIAVLKGQEDSITYSEKSPFSDDKHPIRLILAGIQEKEDKEEPEKASKGEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N234</accession>
    <name>A0A1V0N234_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanyl-tRNA editing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Aminoacyl-tRNA(Ala) deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">alaX2</name>
        <name evidence="3" type="ORF">FAD_0230</name>
        <name evidence="4" type="ORF">HLB00_09710</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000433">
        <property type="protein sequence ID" value="NOL61093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887238.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N234"/>
    <dbReference type="STRING" id="74969.FAD_0230"/>
    <dbReference type="GeneID" id="16025383"/>
    <dbReference type="KEGG" id="fai:FAD_0230"/>
    <dbReference type="OrthoDB" id="11392at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL61093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="237" mass="27231" checksum="1E77C8F835B3C9E2" modified="2017-06-07" version="1">MITEQIFLKDSYLKECEGKVLMCEFTDLTVDKTIFFPTMDGQQNDKGEIVIDGKTYGIVDVWTDGDYIHLISLDTYPENVVGKTIQQKLDWDVRSIHMRFRTAMFIISGLAYKFYNAKSRISQTYDDKAWVDLYIDNITEDIVKNITEEANKIVKQNIPIKIEYMNNNDFPREKQRMSYSTGTLPDDEELRVINIAGLPLQSDYGLYTATTSEVGEIEVASSTVKGKIDKRLTITLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N248</accession>
    <name>A0A1V0N248_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">M48 family metalloprotease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Putative CaaX prenyl protease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_0242</name>
        <name evidence="14" type="ORF">HLB00_08200</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Berkeley</strain>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000305">
        <property type="protein sequence ID" value="NOL60808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887259.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N248"/>
    <dbReference type="STRING" id="74969.FAD_0242"/>
    <dbReference type="GeneID" id="16025405"/>
    <dbReference type="KEGG" id="fai:FAD_0242"/>
    <dbReference type="OrthoDB" id="28389at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07329">
        <property type="entry name" value="M56_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050083">
        <property type="entry name" value="HtpX_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43221">
        <property type="entry name" value="PROTEASE HTPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43221:SF2">
        <property type="entry name" value="PROTEASE HTPX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="12">
        <location>
            <begin position="142"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD84166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="NOL60808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="328" mass="37812" checksum="36B7E73468913E01" modified="2017-06-07" version="1">MTPADKKQILQKSAILSNLSLIIIFFVYIILSEIPFTVYTILVMVSIIIINSLLFMHFKDAMRDQESDENIFQYITDDLSWRYVTYLSIFFLAMLIAQGYIKIVDTYSYLVILNAFIIFIWSISANNPMVNILVRKSEKLQDIYLNNEAADLSTQMGIKEPEIYVINTNGRIANAFEINKRESYVFITSYLMSILNHDEIVGVLAHELSHIKLGHNRKTTMVNFVVFIIMLNLISLAITSTNALLFYLTPVFIIILFLFIFLVSPAIKRHNETEADLNAVKYVNKDYLINGLRRIAETDKIPENVMRSLSLDHPSTEKRIKLIENSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N252</accession>
    <name>A0A1V0N252_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Archease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141479.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N252"/>
    <dbReference type="STRING" id="74969.FAD_0308"/>
    <dbReference type="GeneID" id="84218808"/>
    <dbReference type="KEGG" id="fai:FAD_0308"/>
    <dbReference type="OrthoDB" id="8831at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="entry name" value="Archease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682:SF11">
        <property type="entry name" value="PROTEIN ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="MTH1598-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="133" mass="14852" checksum="693A79EC742A6E92" modified="2017-06-07" version="1">MKYDILDHTADLKIKVYGNSLNSIFENSVAAISDLITGSSSMENTIKRKVEITKQSVDDMLIQLLNDVIFYLETENVLFQRAEINISGNRLNGILSGTKLPDNLCYSNAIKAVTYYNLEISPEEGFAILVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N273</accession>
    <name>A0A1V0N273_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C RNAse domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N273"/>
    <dbReference type="STRING" id="74969.FAD_0269"/>
    <dbReference type="KEGG" id="fai:FAD_0269"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39081">
        <property type="entry name" value="MUT7-C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39081:SF1">
        <property type="entry name" value="MUT7-C RNASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C RNAse" evidence="1">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="156" mass="18451" checksum="8F767BB7ECA53791" modified="2017-06-07" version="1">MIYRHGGEMNKFMADHMLGRTCKWMRIMGYDTGYPQCHSDNDILKKCKEENLILLTRDYEFYKRYSNSIFLDSPDFKEQLKQVVTMFPPDRELFFSRCPECNTILQTVKTETMGPGYDLVKSRYDTVKFCPGCGKYYWEGSHYSRILSQLNNIIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2D2</accession>
    <name>A0A1V0N2D2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Copper transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_0391</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141563.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2D2"/>
    <dbReference type="STRING" id="74969.FAD_0391"/>
    <dbReference type="GeneID" id="31675900"/>
    <dbReference type="KEGG" id="fai:FAD_0391"/>
    <dbReference type="OrthoDB" id="8588at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01512">
        <property type="entry name" value="ATPase-IB2_Cd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
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        <property type="entry name" value="CUATPASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="11">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="676" mass="73481" checksum="28F86124F16565E4" modified="2017-06-07" version="1">MAVDPVCGMYVSQDSKIYSDRDGTRYYFCSQGCKDKFDKPDSESKGLKIKLIVAWPFSIAIIVINYLFSFPLKNYVLLLLVLPVQFYVGLDFYKGAYAAIKNKMGNMDLLISLGTLTAFFFSLIITLVPGLFPVKYTYFDASAFIITLLMTGGYIEDLTKKRANSSANALLSLIPDRVHILKEGIAKDIPMENLVAGDIIQIKPGENIPADGTVVDGTSEIDESMLTGEAESVLKAPGSPVTSGTLNLNGVLSVKVTATGKNSTVNKLYSMIQMASMGRAKIQKISDIFSSYFVPIVLAAAFSSALFWYFYLRSVSNPLYSIIAILVFVSVVVIACPCAIGLAAPITLLISSNESSRNGILIKNSSSMDRLSKIDTVIFDKTGTITDNEPEITAFTTTGDKHLAVSLLYSIESGSNHPVAHAIVNYLKDMNPEKLDISEFREIPGSGVYGKYDGKNVEASRAGDHTSLTMDGIELASINLKHKLRSGIENDIKNLQKNHIRVLIVTGDSLENTKDVAEYLHVDKYYYSIKPEGKAEIVKEEQKTGKYVMFVGDGINDTVAMQTADVGVAMASGSDIATATGDIILLNNDLKNILSTLIIGKYTIKKIKQNVGWAIGYNSALIPVAAGILTPLLGLGIYYVLPIFAALAMGLSSTTVVLNSMQLRKHMERKIALASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2E3</accession>
    <name>A0A1V0N2E3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Indolepyruvate oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141512.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2E3"/>
    <dbReference type="STRING" id="74969.FAD_0340"/>
    <dbReference type="GeneID" id="84218838"/>
    <dbReference type="KEGG" id="fai:FAD_0340"/>
    <dbReference type="OrthoDB" id="53326at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
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    </dbReference>
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        <property type="entry name" value="IorB_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43854">
        <property type="entry name" value="INDOLEPYRUVATE OXIDOREDUCTASE SUBUNIT IORB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43854:SF1">
        <property type="entry name" value="INDOLEPYRUVATE OXIDOREDUCTASE SUBUNIT IORB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate/ketoisovalerate oxidoreductase catalytic" evidence="2">
        <location>
            <begin position="12"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="200" mass="21423" checksum="38E49C2FC9EDFEF7" modified="2017-06-07" version="1">MKTFNIIITGVGGQGIITAGTLISEAAIKMGLNVVMSEIHGLSQRGGSVNVEVRIGNAYGPISPRRKFDLVLGFEPIETMRILSTINSDARVIMNKEKITPISVSLKDAEYPDVNGMALLIPGIKKIYEIDAGDIGNQAGSFRSANTVMIGAVLSLGILPVDEKSIIEALNDRFSGKMLDINLKAMKLGMEAMKKMDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2E4</accession>
    <name>A0A1V0N2E4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sec-independent protein translocase protein TatA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Twin-arginine translocase TatA/TatE family subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0387</name>
        <name evidence="11" type="ORF">HLB00_00590</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000015">
        <property type="protein sequence ID" value="NOL59337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141559.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2E4"/>
    <dbReference type="STRING" id="74969.FAD_0387"/>
    <dbReference type="GeneID" id="84218885"/>
    <dbReference type="KEGG" id="fai:FAD_0387"/>
    <dbReference type="OrthoDB" id="27754at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42982">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42982:SF1">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL59337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="112" mass="12405" checksum="3CD11B07FFA2709C" modified="2017-06-07" version="1">MFDSYMDILIIAVVALIIFGGTKKIPEMARNLGKATGEFKRGQMEIENELKNGASTASNVNKDQINYMKIAEDLNIETKDKTIDQIIGEINQKLGKVPAKESSETTIEAKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2G8</accession>
    <name>A0A1V0N2G8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-dependent repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141586.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2G8"/>
    <dbReference type="STRING" id="74969.FAD_0424"/>
    <dbReference type="GeneID" id="31675933"/>
    <dbReference type="KEGG" id="fai:FAD_0424"/>
    <dbReference type="OrthoDB" id="24735at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050536">
        <property type="entry name" value="DtxR_MntR_Metal-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33238">
        <property type="entry name" value="IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33238:SF7">
        <property type="entry name" value="IRON-DEPENDENT TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="Iron-dependent repressor protein, dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron dependent repressor metal binding and dimerisation" evidence="1">
        <location>
            <begin position="63"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="132" mass="15175" checksum="FF779230DB233612" modified="2017-06-07" version="1">MEYNITRKERDCIVAIHDSSGFPLRLFNIAEILNIKRPTAYELIKRLESKEIIERKNGVIYLTPYGNTIYSEIIMAHRTLEVMLTKSGVNSERACEQIEKIDYLMDDTSIQKLFISLGNPQTCPHGKPVKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2H1</accession>
    <name>A0A1V0N2H1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MMPL family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0404</name>
        <name evidence="10" type="ORF">HLB00_05045</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141574.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2H1"/>
    <dbReference type="STRING" id="74969.FAD_0404"/>
    <dbReference type="GeneID" id="84218915"/>
    <dbReference type="KEGG" id="fai:FAD_0404"/>
    <dbReference type="OrthoDB" id="42357at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050545">
        <property type="entry name" value="Mycobact_MmpL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33406">
        <property type="entry name" value="MEMBRANE PROTEIN MJ1562-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33406:SF6">
        <property type="entry name" value="MEMBRANE PROTEIN YDGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="869"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="763"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL60202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="911" mass="100726" checksum="9B75974DEB7E8924" modified="2017-06-07" version="1">MFESFFYKVGRYVKKNKKKVLVFWIILFLLMAYPATLIFSDTSYNLTNSLVTKNSQSSKANDILSAQFNGSSSDPSIIIVSNNTPIDNLTISRDMMAFQHSMDSYLKSINVGYNSTTSIFTVENKTLMGYSNSTYKLENGTSGLIEYTLLLKEQGYNESYAITNITRTSPEHSTFDDLLGELNLTHGNGVPDFVSYVYNDISAPNNYTGIENYVVSLVNSSQIYLINNAKPLANPLIQINTPYYSNYLYSLYNNSGKKYSAFVSNIINNTTYNKFPVLPSSYGSSSLMNQKNSTLIMIFSYKTNITAAQQSHINSIEKTYSSKISSSSFYLAGSTVANNQLATESLHGMIVALIIGIIVSIIIVGLFFRSPVTAFLPFLIFVFSAVISAGINGLLYKYIFHTTISFITPTLLLILILGIASDYSVYILSRFRSELRAKNKDAIPESAKWAGHAVFTSGTTVALSYIILWISNIPIFSDAGLTNAIAAVVTIIIANTLLIAILAQWGKKTYWPAKIKENQKLPFEKSMEKVAHVALNNRKKIIVIFVIVALGALFLYSTTPTNMDVFELIPASSGVQATSVINSSLGYDLFDPAYVMVNFTSPIMTVNNTTGAITFNSTEYNQTLAMEDKLAASPYVHSISGPGYPYEKKVNYTDLVSSLVYSSQYLNQTATYIGHNHKSVEIVVYLSNVAWSNPSTNYVNKMPSIVNGSGNYTAYVGGTTEYLNNAYSFTSHSFNNMVPLLGITIFIILLIQLASALTPVRLILMVMAAVMLALSLTYIIFYYLLHLPVIIFLPLFVFITLLAVGLDYDIFMITKVQENISKGMNTAEAVKDSIVENGGVIITLGLLLFATFGALYFSGLGIIEEIGVGLALGVLIDTFVSWMFFVPAIMTVMDKYNWWPSRIGKDLPKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2J9</accession>
    <name>A0A1V0N2J9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protease synthase and sporulation negative regulatory protein pai 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795612.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2J9"/>
    <dbReference type="STRING" id="74969.FAD_0400"/>
    <dbReference type="GeneID" id="31675909"/>
    <dbReference type="KEGG" id="fai:FAD_0400"/>
    <dbReference type="OrthoDB" id="57465at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="201" mass="23584" checksum="F662AE448132B030" modified="2017-06-07" version="1">MYVPREFKIDDMEKIVDFVKNYSFGIILSIYNGEIYNTQIPLMLDASGNNIVLKGHMARANMQWYHSKNNKVAVLFTGPHHYISPEWYKEKDSVPTWDYMTVRFDGILETMDDIETKKFLVDLSKSYDPEWTNKGYDKKEYYAKMVLQIAAFTIKVNKITAKFKLTQNHQEDMENVAINLDKVGDEDARLIARYIRREAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2L4</accession>
    <name>A0A1V0N2L4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NMD protein affecting ribosome stability and mRNA decay</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2L4"/>
    <dbReference type="STRING" id="74969.FAD_0427"/>
    <dbReference type="KEGG" id="fai:FAD_0427"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="299" mass="34601" checksum="F76852719D773F27" modified="2017-06-07" version="1">MDLTVCPKCGAVRLNKKWHYDNADKYIIKSATSHVIMDKEDKISSVTSYNIGENEISMELVVEDRNLGDVEKEISINLKTYKESCPVCNKVTGSYYESVIQLRTYTTAYGKILEEAKDTIVKFMKNLNKQDPNSFISRIDTLKEGLDIYLGKKEDAVKIDKLMELDYFCNMKITKSLAGRKDSKDLFRYTHLVRILDLQKGSVVYNKAYYMVKNIKPNTIELLDIHNGSTLTVSSKEFFRATYRIVMKEPEATKFIVLSSTDNESQLMNSRTFEIITFRSPFKQKEVNLYKYEGVFYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2M1</accession>
    <name>A0A1V0N2M1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein-L-isoaspartate O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141581.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2M1"/>
    <dbReference type="STRING" id="74969.FAD_0421"/>
    <dbReference type="GeneID" id="31675930"/>
    <dbReference type="KEGG" id="fai:FAD_0421"/>
    <dbReference type="OrthoDB" id="30774at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="6">
        <location>
            <begin position="51"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="246" mass="27321" checksum="9FE91BF345B8027C" modified="2017-06-07" version="1">MLILKSEEISGILDEKNLIAYFGKERINLPKNSFIEPGDIVRLKNREFIALKPDPQFFNEISGRNTQAVLPLDTSYIIHAAGILPGTCILEAGAGTGSLSYSILKAIGNGGKLVTMDINKSTIDIARGNVERFMEPGNWETIHGDIRSDNLPGKYDAAILDIPDPWDVVENMKKYIVPGGYLVTYSPNFNQAEKNVIAMKKLNFYVLETVELIKRNIIVRENATRPDNNIIDHTAFISIGVRTSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2M4</accession>
    <name>A0A1V0N2M4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Thymidylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0426</name>
        <name evidence="3" type="ORF">HLB00_04980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000170">
        <property type="protein sequence ID" value="NOL60190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887482.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2M4"/>
    <dbReference type="STRING" id="74969.FAD_0426"/>
    <dbReference type="GeneID" id="16025628"/>
    <dbReference type="KEGG" id="fai:FAD_0426"/>
    <dbReference type="OrthoDB" id="28016at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="638" mass="74256" checksum="1F73C583FB46E7FD" modified="2017-06-07" version="1">MNKLANENSPYLLEHSNNPVDWNPWSDEAFNLAKKEDKPVFLSIGYSSCHWCHVMEQESFTDPEVAKRMNSTFVCIKVDREEMPDVDSLYMTFSQVMTGTGGWPLNVILTPDRKPIFAFTYIPRVSRNNMIGIMELAENIDYLWKNKRGEMEKNGDEAISRLRNMERKEENNSPVDYKKAIEATYESLKRNYDSEYGGFGNAPKFPSFHNIIFLLNYYKAHGKEEALEMVKHSLRMMYIGGMYDHVGGGFHRYSTDPFFRIPHFEKMTYDQAMAIIAYSYAYDVTGDTFYKNVVYEIYKFLKQEMFSRGFYTAMDADSEGQEGKYYTWTYEELVENAGKKFVYDFNILPEGNFYDANSRQTGRNILYMGRDIQGDPTTLYKNELEALKKSREKRIKPLTDDKILTDINGLVIKALSIASMIFNDKDMLNTAEGSADFIMNDMYTDKKLMHSYRNGKSSINGMLDDYSFMVSGLLSLYEASLNDIYLDYARDLQKTIMDTFYDKTSGGFYNGMGNLLVRLKESYDNAIPSGFSFEIGNMIVFNYIDDKYRVELEKSINAVSKDIEMQPMFFTYTISNFFNMVDFYKVSTSSPEVMEYLQQHYPYNYFFLKDGSNEISVCDTNKCYIVKNMDELKKLIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2M6</accession>
    <name>A0A1V0N2M6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Transcription initiation factor IIB</fullName>
            <shortName evidence="9">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tfb</name>
        <name evidence="12" type="ORF">FAD_0418</name>
        <name evidence="13" type="ORF">HLB00_04870</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000166">
        <property type="protein sequence ID" value="NOL60168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887474.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2M6"/>
    <dbReference type="STRING" id="74969.FAD_0418"/>
    <dbReference type="GeneID" id="16025620"/>
    <dbReference type="KEGG" id="fai:FAD_0418"/>
    <dbReference type="OrthoDB" id="7429at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20549">
        <property type="entry name" value="CYCLIN_TFIIB_archaea_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20550">
        <property type="entry name" value="CYCLIN_TFIIB_archaea_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000023">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
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        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
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        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001658">
        <property type="entry name" value="PRK00423.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
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        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="11">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="9">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="9">
        <location>
            <begin position="222"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053882"/>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL60168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="311" mass="35254" checksum="A65667C2AC1061CA" modified="2017-06-07" version="1">MATEKKKNIYEIDKCPECGSSQLVRDYERGELVCSNCGLVIDDSYIDEGPEWRAFDSEQSESRARTGSPMTYTIHDKGLSTDISWKNKDSYGKSIPTRNRAQLYRLRKWQKRIKVSNAAERNLSQALQELERMASNLSIPNDVRETSAVIYRKAVKQNMIRGRSIEGVVAGSIYAACRITNVPRTLDEIASVTRVKKKEIGRTYRIMARYLKLNILPSKPDDYVNRFCSKLRLSMEARKRAEEILKMAIDNDLTSGKGPTGVAAAAIYIASLITGERRTQRAIAEVAGVTEVTIRNRYKELTEKLNLTIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2P1</accession>
    <name>A0A1V0N2P1_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="185" mass="20386" checksum="43719AAE97649319" modified="2017-06-07" version="1">MSVLGKNTEAGLKELLTANAEDHMRLNAASNYFEKIGDLETARELKDKANVELGHFNAIFATLVKYEGLKGLVNDMAKEETEQHVSEYTNVANAAKAEGHDDIEAMLCAFSEQEKGIAETLNRAGMKKIISDMAKEETEQHVSEYTNVANAAKAEGHDDIEAMLCAFSEQEKGIAETLKRTRNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Q5</accession>
    <name>A0A1V0N2Q5_9ARCH</name>
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        <submittedName>
            <fullName evidence="5">Deoxycytidine triphosphate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="147" mass="16829" checksum="43EDC729FBC99A90" modified="2017-06-07" version="1">MLNDREIEYNVAAGRIISENYSRDSLTPNGYDIRIGDHELDIIKTNSLFFISSLEKFNMPDNIVASLHIKSKYARRGVFASFGFVDAGFIGNLTMAFYNFGEEFRIKRGMKFVQIVFYEIKTPEKNYPGRSGNYQNSEGINVKSPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Q7</accession>
    <name>A0A1V0N2Q7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0470</name>
        <name evidence="8" type="ORF">HLB00_04215</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="4 5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000145">
        <property type="protein sequence ID" value="NOL60038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887525.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Q7"/>
    <dbReference type="STRING" id="74969.FAD_0470"/>
    <dbReference type="GeneID" id="16025674"/>
    <dbReference type="KEGG" id="fai:FAD_0470"/>
    <dbReference type="OrthoDB" id="264480at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01527">
        <property type="entry name" value="arch_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002243">
        <property type="entry name" value="PRK01153.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF0">
        <property type="entry name" value="BIFUNCTIONAL NMN ADENYLYLTRANSFERASE_NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342">
        <property type="entry name" value="PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="6">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR01527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="172" mass="19954" checksum="5FB01698142BD967" modified="2017-06-07" version="1">MKAFIIGRFQPFHNGHLAIIKHILEHNEYVVIGIGSAQLSHTIMNPFTAGERYLMILNTLENNGISNYYIVPIEDVNSNPMWVAHVESLTPPFHRVYTNNPLVRRLFYEKQYEVLSLPMINRNSWSGTRIRQKILKGEDWRSDVPDTVYNIMKDLDGINRISDLSKTDEDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2S2</accession>
    <name>A0A1V0N2S2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo7</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo7</name>
        <name evidence="4" type="synonym">rpoE</name>
        <name evidence="6" type="ORF">FAD_0461</name>
        <name evidence="7" type="ORF">HLB00_10000</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000442">
        <property type="protein sequence ID" value="NOL61149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887514.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2S2"/>
    <dbReference type="SMR" id="A0A1V0N2S2"/>
    <dbReference type="STRING" id="74969.FAD_0461"/>
    <dbReference type="GeneID" id="16025663"/>
    <dbReference type="KEGG" id="fai:FAD_0461"/>
    <dbReference type="OrthoDB" id="7927at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04331">
        <property type="entry name" value="RNAP_E_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04460">
        <property type="entry name" value="S1_RpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00865">
        <property type="entry name" value="RNApol_arch_Rpo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046399">
        <property type="entry name" value="RNApol_Rpo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006333">
        <property type="entry name" value="PRK08563.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="90"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL61149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="191" mass="21083" checksum="84ADDCDE832D0483" modified="2017-06-07" version="1">MYILLEDEYVIRVPPELLNDNYSDAVAEASKSTLEGKLVDIQEGQKNIGKSYIVSVNSIEMKGEGTIVHGDGGVYQSIKYSALAYFPKMHEVVDGIVVAVQKFGAFIKFGPFEGLLHISQIMDDAINIDMENQRIVGKDSKMELKVGDKIRVRIVALNLSSASLSDSKIGFTAKQPGLGKLEWMKKENVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2S3</accession>
    <name>A0A1V0N2S3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148285748.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2S3"/>
    <dbReference type="STRING" id="74969.FAD_0524"/>
    <dbReference type="GeneID" id="16025728"/>
    <dbReference type="KEGG" id="fai:FAD_0524"/>
    <dbReference type="OrthoDB" id="39312at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07581">
        <property type="entry name" value="nitrilase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="260" mass="29766" checksum="C22D59FA014AEF79" modified="2017-06-07" version="1">MVKIALTQLKPVADKDVSLRNIEYYAGTAAANSADLIVFPEYYMFYSQYKDAIIRNAEVLNGNYIKRIKEISRTNKIGIITGINEVYDHNYYDTAVYVNDGELLNYYRKSHLYDAFGYRESDIYTYGNGPFKISKIGNINFGMLICYDIRFPEVFRNYSLNDADMVILISAWFAGPIKEEQWLSLVSTRALENTTYLATSNMIGGGFTGITTFTDPIGAIINRAAEDEDIIYSIIDTNRISTVRKKMPVLKQRRPELYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2U9</accession>
    <name>A0A1V0N2U9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887618.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2U9"/>
    <dbReference type="STRING" id="74969.FAD_0561"/>
    <dbReference type="GeneID" id="16025768"/>
    <dbReference type="GeneID" id="31676066"/>
    <dbReference type="KEGG" id="fai:FAD_0561"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="7"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="401" mass="43459" checksum="128AFFCB29EB11B8" modified="2017-06-07" version="1">MKDYFHATFAATGSWIGNIYDLTLVTYIYAELEKSYHISLGVVSLLFALGLIGRFFGGLYLGNLSDKIGARRVMAFSTAGYAIFAGVMAFSPDVIILFSARFIQGIFMGGEWTSGTMLGYEFSPASIRQTIFGIIQSGYGIGYALTGIAYILFLPTIAVTWRFFLITGSIPLIIAPYTIMKIPHDNKKIRQAEKKINLRDYKIPLAKSMIMMSGFFSAYFAILSFYPTIATSFGVPASQIGIIMIISSLTVAAGFILFGKLAAIFRKKYLIMAGSMIALAFAWLAVPYFSPIRFLAVPGMVVFSLGIGSMPIIPLLLMDRINPAVRGLISGVSYNFGALFGGLISVLLGTIGGIVGYSQLLLIIDATTLVCLLAVFITGATIKKRNESTSYLSGLSGDMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2W0</accession>
    <name>A0A1V0N2W0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2W0"/>
    <dbReference type="STRING" id="74969.FAD_0521"/>
    <dbReference type="KEGG" id="fai:FAD_0521"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="64" mass="7855" checksum="CD766E1477916D71" modified="2017-06-07" version="1">MWSTLAIHLKIDRESLEKFNVYIERKDSPDPFYPRLRIKIIYAKDRFIYALYWGHRPGTDIFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2X1</accession>
    <name>A0A1V0N2X1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074070.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2X1"/>
    <dbReference type="STRING" id="74969.FAD_0599"/>
    <dbReference type="GeneID" id="16025806"/>
    <dbReference type="KEGG" id="fai:FAD_0599"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000003">
        <property type="entry name" value="Phosphomethylpyrimidine kinase ThiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="262" mass="28482" checksum="69BD1DF00F8D9A41" modified="2017-06-07" version="1">MVARVMSVASTDSGGGAGIMADLKTFTAMKVFGTSVIVTLTAQNSVSVKSIYELPLKFINEQFDAIMEDIGTDAAKTGMLYSAPVISDVTEKFKQYGIKNIVIDPVMISKTNVRLLREDAVETMITKLMKIAELITPNIPEAEKISSMKIRNSEDTKIASKKIYENTGSSVLIKGGHAGSRYSTDILYDGSEYYEFPSRRINTNNTHGTGDTLSASIASYLASGKKLPESIELAKKYIDGAIENSFPMGKGYGALSHFWAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Z4</accession>
    <name>A0A1V0N2Z4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiE</name>
        <name evidence="13" type="ORF">FAD_0597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9 10">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 9 10">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940601.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Z4"/>
    <dbReference type="STRING" id="74969.FAD_0597"/>
    <dbReference type="GeneID" id="84217196"/>
    <dbReference type="KEGG" id="fai:FAD_0597"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF15">
        <property type="entry name" value="THIAMINE-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="12">
        <location>
            <begin position="6"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD84508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="206" mass="22758" checksum="813BAEAC16D1A5CF" modified="2017-06-07" version="1">MKLKGLYLVTPDYSGDWIINATERAIKSGVDILQYRDKTSTFRDKLAIGKKLASICHDYSVPFIVDDDPVLMDMLGADGIHIGKDDVPFDYVKSKYPDHIIGVSTYGSIKDALLYQKLGADYVAFGSFFPTKTKDDATICDIDVLKGIGPINIPVFVIGGISRENIDLVLKYGISGIAVVSAIYSHNDIEDQVSYFKSKLIEYGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N316</accession>
    <name>A0A1V0N316_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">FAD_0577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
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            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84489.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040601">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trm5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="6">
        <location>
            <begin position="70"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="309" mass="35511" checksum="90D0A0516F2C31D4" modified="2017-06-07" version="1">MLHVRVDKENGQETINKLRELDLINREYKILNDGTYVYIPVNKNNIDFYTVDIEGAPSNRIEPEKISFSYDIIGSIAIIKGKTIEDAKYLSDFLKTRKNIKTIYLDKGITGEFRTRQLTLIYGEPVYKTIYRENGIRLMVDVSKAYFSPRLASERLRIAKEVSDGENIVDMFAGIGPFSILIAKNRESSIVAMDKNQNAIDLLLENLKLNRLRGEITPVAGDSGELIQQYENVDRIIMNLPHDASEFVGVAYKSLKIGGLINYYEICDLPTLEGRMESFREMGLELVYKRVVHGFSKYQNMYSMEFRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N322</accession>
    <name>A0A1V0N322_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141714.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N322"/>
    <dbReference type="STRING" id="74969.FAD_0593"/>
    <dbReference type="GeneID" id="84217192"/>
    <dbReference type="KEGG" id="fai:FAD_0593"/>
    <dbReference type="OrthoDB" id="30957at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004544">
        <property type="entry name" value="TF_aIF-2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00491">
        <property type="entry name" value="aIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="8"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="NCBIfam" id="TIGR00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="580" mass="64173" checksum="0F206AB0AF5B2C94" modified="2017-06-07" version="1">METTKKNLREPIVCVLGHVDHGKTTLLDDIRGTTVAKKEAGGITQKIGATEIDKNTLETNIKNYFKNIQVTIPGLLFIDTPGHVAFANMRSMGGALADIAILVIDVNEGLKPQTIESIDVLKKYKTPFIIAANKIDMIPYFVSSKDTSFKETLSKQRKEYVDFLDEKIYKIINDLYVKGISSDRYDRITDFTKSFAIVPISAKLNIGVPDILMVLTGLAQRFLEEHIQFESKSTRGSVIEIKKEGSLGTTLDTILYQGVLHKGDKIALNTIAGPAVTKVKAIIATGKKGMVEKESIKSAAGIRILITDKLDVLSGTSIIAIKGSKTDAAFNELINESKPDIKLSENGITIKAEAIGSLEAIAYEMEQNKINVREAQIGDITKRDIINVSTLNNPLDRVIVGFNVNTSGDAKEAMETNNAKVISGNVIYSMIDDLTKWLEFKKNEIEEEKKNNKPVPSKLVIMPDYIFRAAKPVIVGIKVLSGRVKVGDKLINGKNKYAGTIKSLRDGDVNHQFADKGSELSCAIDGVTLNRQIFPDEDLYVDVPENVVKEMKDQDMDPDVKTTMEELIKIKRKDEQFWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N330</accession>
    <name>A0A1V0N330_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Diaminopimelate decarboxylase</fullName>
            <ecNumber evidence="5 7">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>meso-2,6-diaminopimelate + H(+) = L-lysine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="5 7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887698.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N330"/>
    <dbReference type="STRING" id="74969.FAD_0637"/>
    <dbReference type="GeneID" id="16025847"/>
    <dbReference type="GeneID" id="31676142"/>
    <dbReference type="KEGG" id="fai:FAD_0637"/>
    <dbReference type="OrthoDB" id="18565at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000003">
        <property type="entry name" value="Diaminopimelate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727">
        <property type="entry name" value="DIAMINOPIMELATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727:SF2">
        <property type="entry name" value="GROUP IV DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="421" mass="45493" checksum="F80E0C6B57014AB9" modified="2017-06-07" version="1">MVNIKKLYPGLSPDVSEFAGKSIKNISDAYGTPVIVYNMARVRENIRRIRDAFNGINIKVHFAVKSNYNPYIVSQIIKEGTGIDAANYNEVKLAIMCGLGSRDIIATPNNLSGTELRTIKEEGVAINFDHEGQMGLLKGSLPETVSFRINPGIGKGEFPGITTGGKNVKFGISVDDAISAYSAAIKAGVKHFGIHMMTGSNVLEPEFFNESSGLFFKIAETISDRTGIDFDFIDIGGGFGVPYTSDEHALDIGKTAGYISDNFRASNNRGYFKDSRLIIEPGRYIVADSAILLSKVTSIKHSDRELIGIDASMNTLIRIPLYGARHGILLSGHGENTSSSRFDIVGQVCENTDYIAKDISIPEPAVGDIVVIADAGAYVASMASNYNLLSRPAELVLEGDREILTKGHDGLESMLAGYKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N349</accession>
    <name>A0A1V0N349_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF981 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0610</name>
        <name evidence="3" type="ORF">HLB00_09670</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000431">
        <property type="protein sequence ID" value="NOL61085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887668.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N349"/>
    <dbReference type="STRING" id="74969.FAD_0610"/>
    <dbReference type="GeneID" id="16025817"/>
    <dbReference type="GeneID" id="31676115"/>
    <dbReference type="KEGG" id="fai:FAD_0610"/>
    <dbReference type="OrthoDB" id="57193at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009324">
        <property type="entry name" value="DUF981"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06168">
        <property type="entry name" value="DUF981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL61085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="187" mass="20500" checksum="02ED3EFF6188B81F" modified="2017-06-07" version="1">MGFVDPLAVMLLSLGVSAGLISAFFYQVAKGRDVKELVVPAFIFGGFDFMSGFEMSEFWPLPGSYNMLFGDPIMILGMLLIAGSIMIYKGYNLRTLSIPGVMLGVYLFIESAAMVNFKLESGDNLFAAMGLYIMSGISAVYSVVLFAKPEKDRKYLYYVAFILLALTALIALFIGYEAIYGHLQAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N359</accession>
    <name>A0A1V0N359_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0669</name>
        <name evidence="3" type="ORF">HLB00_07535</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000277">
        <property type="protein sequence ID" value="NOL60679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887735.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N359"/>
    <dbReference type="STRING" id="74969.FAD_0669"/>
    <dbReference type="GeneID" id="16025886"/>
    <dbReference type="GeneID" id="31676171"/>
    <dbReference type="KEGG" id="fai:FAD_0669"/>
    <dbReference type="OrthoDB" id="57059at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="Zn_Ribbon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="117" mass="13119" checksum="DBCF66CDE75E2B56" modified="2017-06-07" version="1">MSNLGKYAPSILIFLLDHDKVKKTDLLKVVPSTGTMESTVKRLEEQGVIRTEKKYIGRRIIYISLTEYGHAIAGQFKNINEITNSKSSGQYKICPVCGTKNDEDAKYCKNCGSKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N373</accession>
    <name>A0A1V0N373_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940625.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N373"/>
    <dbReference type="STRING" id="74969.FAD_0697"/>
    <dbReference type="GeneID" id="31676199"/>
    <dbReference type="KEGG" id="fai:FAD_0697"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="419"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="511" mass="57966" checksum="4E63C3B732E5F5CF" modified="2017-06-07" version="1">MVEVLEDSKRSDPFITYFKNIMTYGEFEGYSNAVAVEFSMYCDPGDIIAIIAENIPQFPIVQYASWKNSCIFVPLSPLDSENEITGKIKFIDARVVVISSEFREKFSSLMEIQSLHVLYTDPQTFGKLPDNMAEKYITGIMKEELNLRLKKEFKGYYPEPGSIAMLVFTSGTSGRQKAAEITHSNIYSASYIYREWYSVQPQDKNLCIAPFFHITGLIFGISLTVLAHSSMALTYRFNAENALETVESEKTTITMFVATAYRAMINSWSNVDKIKTRLSSMRLWSAGGMPMPYKTEIEWKEMSGKWIYMAYGLTESTSPVALWEYPYTDNIPLYNGIVTAGKPANYTRIVRARGGELVVSGPQVIRRYYKNPEDTEKASGKYGLKTGDICYIDSNGYIYIIDRKKDLIDVSGYKVVPAEVENAIRTCDQVEDVVVVGENDEYKGEVPVAYVKLSTIPDNYEEMKKNIYGVCKKELARYKVPARIIFVRDMPLNASGKIKRSGIHSVEVVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N391</accession>
    <name>A0A1V0N391_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0702</name>
        <name evidence="3" type="ORF">HLB00_02820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000091">
        <property type="protein sequence ID" value="NOL59767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141811.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N391"/>
    <dbReference type="STRING" id="74969.FAD_0702"/>
    <dbReference type="GeneID" id="84217325"/>
    <dbReference type="KEGG" id="fai:FAD_0702"/>
    <dbReference type="OrthoDB" id="43754at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052829">
        <property type="entry name" value="N-acetyltransferase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43259:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43259">
        <property type="entry name" value="SPT10P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="155" mass="18316" checksum="8FB048477B294B52" modified="2017-06-07" version="1">MVNIRLMEKKDVEMVMEQLLRLKHLNEEFDPLLKVSEGNEKEISEKIIRIIEDKDNHINLVAEEGNRVIGMITSDIIFRIYYDPKYEARIREFYVMPEFRAKGIGMKLIEKLKEVAAQRNIKMVSAEFPSLNLLASKFYESIDFKELIKIYSKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N392</accession>
    <name>A0A1V0N392_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0659</name>
        <name evidence="10" type="ORF">HLB00_09920</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000440">
        <property type="protein sequence ID" value="NOL61134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141758.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N392"/>
    <dbReference type="STRING" id="74969.FAD_0659"/>
    <dbReference type="GeneID" id="84217261"/>
    <dbReference type="KEGG" id="fai:FAD_0659"/>
    <dbReference type="OrthoDB" id="312811at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050366">
        <property type="entry name" value="BP-dependent_transpt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43386:SF1">
        <property type="entry name" value="D,D-DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DDPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43386">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="107"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL61134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="309" mass="34224" checksum="7233218DB3FB2E23" modified="2017-06-07" version="1">MIDENTFEKTTTFKKAGYFSQFIKDKSAIIGIIIVGWFFVWSLIQGLLEDIASYTSDSKLGYLLLPSNPFKINYAASLEGPSTHSLALIFGTNFDGESILSRMLYSMPRDALVAVIVVFSAIIIGSLLGIISGWKGGWIENIIMRLTDSFLSIPALILVIAISIPLKAGFDAVIISLSIVWWPTYARFFRGQTLKIKNMDYMQAAKINGVKKISLFFRYLFLNSIDPVIAYAALDFGNVILTYATLAFLGIGLTIPIPELGAMASNGLGYLPADWWYSVFPSVSILIIVAGFVLVGDRYQDIINNRIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N396</accession>
    <name>A0A1V0N396_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase I</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">folE</name>
        <name evidence="6" type="ORF">FAD_0724</name>
        <name evidence="7" type="ORF">HLB00_01140</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000031">
        <property type="protein sequence ID" value="NOL59442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141849.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N396"/>
    <dbReference type="STRING" id="74969.FAD_0724"/>
    <dbReference type="GeneID" id="84217347"/>
    <dbReference type="KEGG" id="fai:FAD_0724"/>
    <dbReference type="OrthoDB" id="8438at2157"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="5">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="191" mass="22068" checksum="2A3D46A244F11614" modified="2017-06-07" version="1">MEENSRDILKESIKALVYNLHEEYGWFNDEELKNTPRRIENFYREWYGARNFTFTKFKITGHESMVIVKNISFYSMCSHHLLPFFGNINIAYLPRPGGYIAGVSKLVRSVNKIASKPQLQENMTSEIVNLLYDNLNPLFVMVTANGQHMCMMMRGVKQESATMVTSSVKYSDVVKTELESLKNEALKMMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3E8</accession>
    <name>A0A1V0N3E8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoB--CoM heterodisulfide reductase iron-sulfur subunit B family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Succinate dehydrogenase, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0715</name>
        <name evidence="4" type="ORF">HLB00_01185</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000033">
        <property type="protein sequence ID" value="NOL59451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141837.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3E8"/>
    <dbReference type="STRING" id="74969.FAD_0715"/>
    <dbReference type="GeneID" id="84217338"/>
    <dbReference type="KEGG" id="fai:FAD_0715"/>
    <dbReference type="OrthoDB" id="144689at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051278">
        <property type="entry name" value="HdrB/HdrD_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42947">
        <property type="entry name" value="COB--COM HETERODISULFIDE REDUCTASE SUBUNIT B 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42947:SF1">
        <property type="entry name" value="COB--COM HETERODISULFIDE REDUCTASE SUBUNIT B 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich" evidence="2">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteine-rich" evidence="2">
        <location>
            <begin position="150"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="291" mass="32416" checksum="76FC40E103DCA8D6" modified="2017-06-07" version="1">MKVAYYPGCASHGIAKDVDIATQLIAKDLDLELMEVDDWNCCGGGFMDDKNESSHTSLNLRNLEKVEKMGYDKMATPCSVCLNSHKMAVDKYENDPVLKEDVDQRLKNANMEEYDNGVESEHFIWVLIRDVGIENIRKHVKRPLTNIKVGTYYGCQLLRPSNVMGFESAFNPHSVMDLVAATGATPVAFPMKSACCGFPLMGSNPTVALKMANNVLSSARDNGSEMLVHPCSLCHLQLDVTQTKIQREFKQDWRLPALYITQLIGLSFGYSPKELGLSKMSMEYLSSRGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3G2</accession>
    <name>A0A1V0N3G2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0790</name>
        <name evidence="6" type="ORF">HLB00_02090</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000060">
        <property type="protein sequence ID" value="NOL59624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141981.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3G2"/>
    <dbReference type="STRING" id="74969.FAD_0790"/>
    <dbReference type="GeneID" id="31676292"/>
    <dbReference type="KEGG" id="fai:FAD_0790"/>
    <dbReference type="OrthoDB" id="350578at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF129">
        <property type="entry name" value="SERINE PROTEASE HTRA2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="224"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="320" mass="34067" checksum="16EEDF172F400963" modified="2017-06-07" version="1">MNNIEELNNNTVEIAEKASRAVVSINSTIYSGNFGYGITPVKGAGSGFIISHDGYILTNNHVIEGAETVDVVLNDGRKFKGEIAGTDPQTDVALVKIPGDDFPVIELGDSEKIRVGSIVLAIGNALGLPGGHTVSMGVISAKNRPMPWADFIFEGLLQTDAAINPGNSGGPLVDLTGKAVGINTAMIAQANGIGFSIPVNTIKKELNDIINTGKVKRNYIGISGIEINESSQGRYGVKLENGVMVARIDRYSPAYDAGLRPGDVITEFAGTPVKSMRDLIKGVAEMKGNTDVIFIRGGSKYRTTIEYKKETKKRIEILDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3G6</accession>
    <name>A0A1V0N3G6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141910.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3G6"/>
    <dbReference type="STRING" id="74969.FAD_0750"/>
    <dbReference type="GeneID" id="31676253"/>
    <dbReference type="KEGG" id="fai:FAD_0750"/>
    <dbReference type="OrthoDB" id="57526at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="266" mass="31504" checksum="6BCF50FB4D8F4A9B" modified="2017-06-07" version="1">MLYIYGTVFNNQGTLISSIESLSKINIEKQFLIVDNFSTDGTYELLDKIKENYNIVIKRIKCSRGSGRQIAMEMGYDKATNEDLFMTFDLDTTYTSRFVTLIEYGVKILNHNEIFLNQLCFKQANFTVQWKDLNNGEDWERMANFLYSGYGIINVPDKYYDLGNNYAGKKREKRYATGINYYTRMIKNQIDLFRGWNISSYKNLKQFMEYADAKSSHFIPLLLILIYIKLFNHVYKYSDEINILYVKHKMQFIDVPYTDKEDLNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3H5</accession>
    <name>A0A1V0N3H5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA transferases/carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">caiB</name>
        <name evidence="2" type="ORF">FAD_0745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141902.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3H5"/>
    <dbReference type="GeneID" id="31676248"/>
    <dbReference type="KEGG" id="fai:FAD_0745"/>
    <dbReference type="OrthoDB" id="28444at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="399" mass="44245" checksum="BD4AA16034FF05EB" modified="2017-06-07" version="1">MENALKGIKILDLTQAMSGPFATMLLGDLGADIIKIEPPDGDQTRSWAPPYMEGISSYFMSTNRNKRSLAINLKTEEGKQIFRKLIAESDVLVENFRPGVIEKLGFSYDIARSINKNIVYCSISGYGQTGPMRDYPGYDLAILAMSGLLGITGNPGESPVKFAVPIADITTALFATVSILSALYNRERTGEGQYIDLSMLDSNFLVLTHQLMSYLSTGKNPEKLGSAHSSIAPYQAYKTLDSYIVITVGTEKLWKTFCETIDPGLENRTEFKTNVDRVSHRELLKKEIEDALKKKTTEDIYRTLVQNGIPCAPVNSVADAASSSQIKFREMIINMDTDYGKIRIPGTPFKLSKTPGEIRFPPPSLGSGNEEILQDIGMTSGQIEELYNKNIIFKRMKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3K3</accession>
    <name>A0A1V0N3K3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thermopsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142038.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3K3"/>
    <dbReference type="STRING" id="74969.FAD_0833"/>
    <dbReference type="GeneID" id="31676333"/>
    <dbReference type="KEGG" id="fai:FAD_0833"/>
    <dbReference type="OrthoDB" id="57559at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007981">
        <property type="entry name" value="Peptidase_A5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05317">
        <property type="entry name" value="Thermopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="698" mass="75341" checksum="3C97CC2856B85C6C" modified="2017-06-07" version="1">MVHGKKSKWKKILPIAIALLFVLMAVSSITTHSTDMLSSSVNSHASKGPGVTNSSSVLPSNESNYSSVNPENLYRNEPAPVGMADYGLGTGTLFGGYTPYEYNTTSFLGSAKIYNLSVVDNSTGNKCMSVQFNVNLVFNNSNNKYVYWVQDVAFINTSSRAITFIDNIWNMTSSGASMYNSTVNGTGTVSNYSDSGYYYSIASCTLPGNDIKLPNLATINFMVNSTMKNGSPEVELMYNDGYGWVTYDSPVFIFATNVTSDQSFVVDGYNYEPDGYSFYDAELILGGPGDGSSTVDMSSNIQLGIEYWNGHNYQEITNAFNYGSDTAETISNVTSTAEYYTSNGTIFENVTAGDGSLSQVYSSADISLLNISTPFSSGSISVNGTEYSFVKHEVNLTLAPGEYNLSIYNGTILYKNLTVNLTAGEYLPLNVAPKYNVVFTQTGLPAGTAWSVTINGKTESSVTNTIVFVLANDTYTYTVETPDKIYKAEHYSGDIVVNGSSYKSIIKFSKVTYEVKFIEAGLPGGSVWYVNLSSTVKSGPITGNSFSFALINGTYTYRTSIANEPYEPVPSSSGISVHGGNISTTITFSRMYTVKFVETGLPAGTTWLVTLNGTTESSDNNTILFALHNGTYTYTVSGVNGNKISSNSGNVDVNGKNVTVNNIKYTPEHNYTLYYGIGVVAAIAIIISAAIVAIRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3K4</accession>
    <name>A0A1V0N3K4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0840</name>
        <name evidence="2" type="ORF">HLB00_09880</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000439">
        <property type="protein sequence ID" value="NOL61126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951107.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3K4"/>
    <dbReference type="STRING" id="74969.FAD_0840"/>
    <dbReference type="GeneID" id="84217460"/>
    <dbReference type="KEGG" id="fai:FAD_0840"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL61126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="110" mass="12868" checksum="ED1AE50AA5EFD131" modified="2017-06-07" version="1">MVQSSIHTDCEENLGAGICPCHYGNRKSHRGVREIMGTRVILHRIDRARFFGFEYVNYGGVFVPVSDVEKTLIDFNYYHIKLSEETLESIRKKIDKVKLLEYEKRMIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3L0</accession>
    <name>A0A1V0N3L0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0763</name>
        <name evidence="4" type="ORF">HLB00_07685</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000287">
        <property type="protein sequence ID" value="NOL60709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141936.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3L0"/>
    <dbReference type="STRING" id="74969.FAD_0763"/>
    <dbReference type="GeneID" id="31676266"/>
    <dbReference type="KEGG" id="fai:FAD_0763"/>
    <dbReference type="OrthoDB" id="41015at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="245" mass="28343" checksum="450FF73D12F6E44B" modified="2017-06-07" version="1">MKIAIRALQSRRMPLESAMEYISSLNFPENEIIVFPEKFITTKVDMNSLGSLLNSIKIKNTIILGSLSYVDRFVYNRSFLIRNREIIGWQDKINLYKAESTKYTSGNQLKLFNIEGLKIGILVCYDLDFPDYARILFRKHCDVIFNPSLIRRDFHSEWHLYVKTRALENRIPIISVNSISDDFQGDSIVVAPEEGVGGVRINAVTSKCDDIVYQFDTSDYSKAREQRLREENLNIQNVNFLEAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3M2</accession>
    <name>A0A1V0N3M2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940611.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3M2"/>
    <dbReference type="STRING" id="74969.FAD_0838"/>
    <dbReference type="GeneID" id="31676338"/>
    <dbReference type="KEGG" id="fai:FAD_0838"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="151" mass="17336" checksum="E5032EBF705661C1" modified="2017-06-07" version="1">MNTINLLDTIKNDYKGVFRTYDIEIIENSNIKYSSLVANRLVEHGYAKRAGRNKFYLPGTDIFAIASNILEPSYIGISSAFSYYNLVTQIYDTIYVISSKRHKDIEIEGYKIKFITLKNTKIYGYHIDKNTYISISDPEKAIVDGCVCNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3P0</accession>
    <name>A0A1V0N3P0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142112.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3P0"/>
    <dbReference type="STRING" id="74969.FAD_0878"/>
    <dbReference type="GeneID" id="31676382"/>
    <dbReference type="KEGG" id="fai:FAD_0878"/>
    <dbReference type="OrthoDB" id="380554at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01483">
        <property type="entry name" value="E1_enzyme_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046741">
        <property type="entry name" value="DUF6791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004804">
        <property type="entry name" value="PRK06153.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004805">
        <property type="entry name" value="PRK06153.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20590">
        <property type="entry name" value="DUF6791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6791" evidence="2">
        <location>
            <begin position="10"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="171"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="394" mass="44162" checksum="E6E34E2FAA8E5406" modified="2017-06-07" version="1">MSPELLSHSADLKQLRDEGYEISIVNAYLLVKHVPYVDSTKNIAYGTLISTLDIAGDKTVKPKSHVALWAGSYPCNSEGIQLSMLVNDPNKNEKICDGLYATLSFSQKLRPEGYNDYYEKVTTYIKILEGYAHVIDPKATARTFPVIPSDKDTSVFCYIDTATSRAGISAANEKLKTGKIAIVGLGGTGSYVLDFIAKTPVEEIHLFDGDEFLQHNAFRSPGAPAIDDLKQRQHKVDRFAEVYSKMRRNIFPHPQYLDENNVSELKDMNFVFLCMDGQNKKAIIDFLLENKIPFIDTGIDIYNTDGVLGGNARVTTCTPDFNGHITKRIDFKGDGNNEYESNIQIAEINALNAAFAVIKWKKLSGFYFDRENEYNTTYGIITNSIDNDEHNEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3R5</accession>
    <name>A0A1V0N3R5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142151.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3R5"/>
    <dbReference type="STRING" id="74969.FAD_0901"/>
    <dbReference type="GeneID" id="31676404"/>
    <dbReference type="KEGG" id="fai:FAD_0901"/>
    <dbReference type="OrthoDB" id="9014at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052539">
        <property type="entry name" value="MGD_biosynthesis_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40072:SF1">
        <property type="entry name" value="MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS ADAPTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40072">
        <property type="entry name" value="MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS ADAPTER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)" evidence="1">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="152" mass="17312" checksum="B02074C9D6CDC79A" modified="2017-06-07" version="1">MKIFSFFGSSSSGKTTIISNIISELSGSMKIGYIKNIPHDNISLDTEYKDTWKMENAGAYRIYGLAPSRTYSMVEKETSPDEIIEKENDVDIFIIEGFRAFDKSIKFLVLGSEDYLAIKHDYTITATNRTYEGRAIKYPEEFHKIISILKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3S4</accession>
    <name>A0A1V0N3S4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142026.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3S4"/>
    <dbReference type="STRING" id="74969.FAD_0826"/>
    <dbReference type="GeneID" id="31676327"/>
    <dbReference type="KEGG" id="fai:FAD_0826"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="369" mass="41856" checksum="C24DDF80958F3FE6" modified="2017-06-07" version="1">MATIKILQLSHGKIIPDYISAYAMRVNHLLEGNSWKICSVGGLILHDVKENKLEEYRSLLSTTYSVLKGNRSLEIAISKGILLRKKYINSVRALISEADAIIFEGPWEYPLFEKLLENKFVVYDAHNVESLLRTGNKYHDYTEEIEGKLVQRSNLLISVSENDLKYFKEKFNPGNAILLTHLLKNVKYQWNGEDSRDIIFIGSIYGPNIEAVEFILSLARTMPDFQFHIIGNVNTHGFPHKPGNVQFHGLIQDAEKDNLFGNSCIALNPIFTGGGRNVKMIDYIMHGLPVISTEIGIRGLSQYDLSGAVAVEKPEHFKETILKLTGNRDKLKSMSENTFKLKEKILATESSFTAYDIISKEYEKWKSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3X4</accession>
    <name>A0A1V0N3X4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0896</name>
        <name evidence="3" type="ORF">HLB00_02375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000072">
        <property type="protein sequence ID" value="NOL59680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142143.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3X4"/>
    <dbReference type="STRING" id="74969.FAD_0896"/>
    <dbReference type="GeneID" id="31676400"/>
    <dbReference type="KEGG" id="fai:FAD_0896"/>
    <dbReference type="OrthoDB" id="132045at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="68" mass="8281" checksum="C7BAA89D3B2E67F8" modified="2017-06-07" version="1">MIFIDRINELKALNDRYDSGKAEFIVIYGRRRVGKTELLKQFMNNHDWIILTMWNNRQRYNLIGSLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Y3</accession>
    <name>A0A1V0N3Y3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase OrfA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142195.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Y3"/>
    <dbReference type="STRING" id="74969.FAD_0929"/>
    <dbReference type="GeneID" id="31676434"/>
    <dbReference type="KEGG" id="fai:FAD_0929"/>
    <dbReference type="OrthoDB" id="374875at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052546">
        <property type="entry name" value="Transposase_8_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33609">
        <property type="entry name" value="LOW CALCIUM RESPONSE LOCUS PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33609:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="89" mass="10226" checksum="9F9BC61A8BE229D2" modified="2017-06-07" version="1">MEKFTADEKVAIVMESFTSNNIAELCRRHGVSIASFYKWRDKFIESGKQGFYGSGGNNGYEKEIEKLKRLVGDQALVIDELKKNYRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Z0</accession>
    <name>A0A1V0N3Z0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951118.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Z0"/>
    <dbReference type="STRING" id="74969.FAD_0904"/>
    <dbReference type="GeneID" id="31676407"/>
    <dbReference type="KEGG" id="fai:FAD_0904"/>
    <dbReference type="OrthoDB" id="379328at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38433">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38433:SF1">
        <property type="entry name" value="DUF1641 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15858" checksum="FC05EFB7201F2747" modified="2017-06-07" version="1">MSKPIEYVETEEDKLPAMIPDEYKESFNNLLKTIKSLNDSGFLTLVNAMSVNYKYIIDTFSEQFNSDTTKKSLTNVMSVFDLLSKLDPDMMVSLMNRLGDSINNAGKPESGGLMSIVRMMNSSDVAGPISVLLKILAGMSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Z5</accession>
    <name>A0A1V0N3Z5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/polyamine/organocation superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="44220at2157"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="1.20.1740.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
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        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
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    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="254"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="274"/>
            <end position="304"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
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    </feature>
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            <begin position="15"/>
            <end position="429"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A1V0N411_9ARCH</name>
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        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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            <taxon>Thermoplasmatales</taxon>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1V0N411"/>
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    <dbReference type="GeneID" id="31676510"/>
    <dbReference type="KEGG" id="fai:FAD_1011"/>
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="42"/>
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            <end position="102"/>
        </location>
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        </location>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ARD84892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="402" mass="43598" checksum="A28A0AC57525CBB5" modified="2017-06-07" version="1">MGNSYKQEINEKANRKYGLIVALLIFAIMVVSNIPTPLYALYAIKFNFGSLAIAGIFATYVVFLIPSLLFWGQYSDVKGGKIPIILGIIFEIAGIISFFLAGNISELFLARAFQGLASGAISGPASALLFHYRGKAGAILTSVSTSSGTAVGPLLGGVMAEYLPFHLKLVYILSLIIIIIPVARIAPMINKLIINKRSNHNVFEFHFPKLDMAEKGLFTLSAATAFIAWSITAFYMSMSPLYIIRLLSISNIAITGLIVFLMLGIASIMQILSMKSTIFSSLLTGMISLTIAIALIVISFPFKSMEIFIVATIMTGIGQGFAFTGATREIRTISPPLKMGGVLSNYYIIIYFGVGIPTVILGLIDMISGLFSGILYYGSSLIICSLIIIIFLHKYRIKIAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N420</accession>
    <name>A0A1V0N420_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPR1/FUN34/yaaH family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
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            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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            <taxon>Thermoplasmatales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
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        <property type="protein sequence ID" value="ARD84902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142354.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N420"/>
    <dbReference type="STRING" id="74969.FAD_1021"/>
    <dbReference type="GeneID" id="31676520"/>
    <dbReference type="KEGG" id="fai:FAD_1021"/>
    <dbReference type="OrthoDB" id="53209at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015360">
        <property type="term" value="F:acetate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071422">
        <property type="term" value="P:succinate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047623">
        <property type="entry name" value="SatP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178:SF3">
        <property type="entry name" value="SUCCINATE-ACETATE_PROTON SYMPORTER SATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="201" mass="21525" checksum="654A5408765B1841" modified="2017-06-07" version="1">MDETENVFGTVFKVDPAPLGLTGFALTTFMLSFVNAGIIGSKGGTGMAISFAFAYGGIAQLIAGQWEMRRGSQFGFVAFSSYGAFWLWYVFLEVAAHFSVITVTNEALGVSLLLWGVFTLYMFVTAIRLNLGLMFTFLFLWLTFFFLGAGAMSGVVIITHIGGYLGILAAAFAIYTAFAVVTNSNHAGRIPLGAGIGSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N423</accession>
    <name>A0A1V0N423_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1059 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143157.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N423"/>
    <dbReference type="GeneID" id="31676471"/>
    <dbReference type="KEGG" id="fai:FAD_0972"/>
    <dbReference type="OrthoDB" id="9023at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6421" checksum="50BD7C35A3BC752B" modified="2017-06-07" version="1">MAYEFKCKDIGMDCGFDVKADSVDELIPVIQAHAKNAHNINEITPELFGKVKAAIKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N435</accession>
    <name>A0A1V0N435_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IS605 OrfB family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142399.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N435"/>
    <dbReference type="STRING" id="74969.FAD_1039"/>
    <dbReference type="GeneID" id="84217636"/>
    <dbReference type="KEGG" id="fai:FAD_1039"/>
    <dbReference type="OrthoDB" id="57553at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="5">
        <location>
            <begin position="201"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="6">
        <location>
            <begin position="336"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="460" mass="53985" checksum="F30D8637F227E55B" modified="2017-06-07" version="1">MIETKRNKIKNSLRITRERRKTQDVIILKLKIDNDKLNNNTIKALNTIFLEAKWLYNYILDKEFNNDIFNIDPKIKNVNVYVKDHYETRKLKYLSSQMKEEIINRAMDNIRGLHKLKEKGSKVGKLKFKSFITSIPLNQYTITYKIINNNYIKIQNIKQLLKVNGLDNLECYYEPASALLINKNNNYYIYITAYKNKYILEKPVNNQKILSFDLGIKNQLTCSNGLILNYNIPKSKKEIRLQRSLSRKAKYVEGTKKLSREQSKNYYKNKNKLNREQNKTTNKRKDTINKITHYLTSNYDIVVTQNDNIRGWKHLFGKRIESTGIGGIIDALKHKASTLILIDRFISTTKECSNCHNKYNIKLDERIYNCPNCGFIIDRDYNSALNDMYYGIIKLNELLKIKNRKLNNYFKKYNINLNVPMERRELTPVEIIASGFEGPNVSPYVKLSMVNEAGSLYALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N442</accession>
    <name>A0A1V0N442_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Death-on-curing family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142295.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N442"/>
    <dbReference type="GeneID" id="31676489"/>
    <dbReference type="KEGG" id="fai:FAD_0990"/>
    <dbReference type="OrthoDB" id="123270at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1870">
        <property type="entry name" value="Fic/DOC protein, Fido domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053737">
        <property type="entry name" value="Type_II_TA_Toxin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426">
        <property type="entry name" value="HOMOLOGY TO DEATH-ON-CURING PROTEIN OF PHAGE P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426:SF1">
        <property type="entry name" value="HOMOLOGY TO DEATH-ON-CURING PROTEIN OF PHAGE P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="216" mass="25301" checksum="BC85D2DE3A56C063" modified="2017-06-07" version="1">MKFTYKNIIEIHEKIAKHYSIDSNYLNINAIKSIVYRMNDNFNNSDIYPTIYDKAAVLFMRIIRCHPFIDGNKRTALASLSEYLVDNNIVYLTFSSDIRFSVEIAKIHSNNISDSHILKNIKRWIMFHSANSNDDIDIIIDRQLSLIKTIIGVAKNKNRPSMIDKTFDYWYATDIYPYYTPSYSGLEGIMQELEMEKVFFKQVDSLIELILKVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N445</accession>
    <name>A0A1V0N445_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142267.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N445"/>
    <dbReference type="GeneID" id="31676473"/>
    <dbReference type="KEGG" id="fai:FAD_0974"/>
    <dbReference type="OrthoDB" id="371918at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295:SF8">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="40"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="203"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="48149" checksum="3CBC92D789D50241" modified="2017-06-07" version="1">MILKETLKRVVNSQRDDLKAFEYGTTREKLEDINLDMPYAIILSGIRRCGKSTLLHQYISNIDNYYYLNFEDVRLNDFDSNDFEKLDNVFKELFKECNYYMFDEIQNIDKWEVFVRQKLDIAKRFLITGSNASLLSRELGTKLTGRHINMELFPFSFKEFLSLENFEANIESFMKYLQEGGFPEYLKYKKEEILRELFIDIIERDIVARHQLRDSKLLKNIALYLLTNTGNEFSYNKLKKTFKLGSVNTVISFIHYLEDSYLLFTIPKFDYSFKKQIMNQKKVYCIDNKLILANSASFSMDYGRLLENSVFLFIRRTYKEIFYYKGNNECDFIVKEKNNIKMAVQVTSELNVDNKKREIDGIIEAVKKFNLSTGLIITLDQEDAFEIENKKILVKPVWKWMLEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N472</accession>
    <name>A0A1V0N472_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase mutator family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143160.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N472"/>
    <dbReference type="STRING" id="74969.FAD_1023"/>
    <dbReference type="GeneID" id="31676522"/>
    <dbReference type="KEGG" id="fai:FAD_1023"/>
    <dbReference type="OrthoDB" id="56934at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033543">
        <property type="entry name" value="transpos_IS256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217:SF7">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="383" mass="44990" checksum="D78AB52BA5ED9B69" modified="2017-06-07" version="1">MQDQLEVIKEKIKSYGLNRENMRDLKKWILNDLMNEEAEEQINASRYERNSNRKDYRNGYKQRSLLTTDGKIILDKPQFRETSFHTAVFDNYSRVERAVESIILESYLSGVSTRNVNKVVKSLDVQVSPSYVSSLYSRLDKTVNEFLERKIDGVYKFIYIDGTYLKIRNNGRYRNKAIYICVGINSDGYREILGARIYDSETEIQWELFFDDLKNRGLNSVEMVISDGNKGIREAVKQSFPGASWQYCHVHFMRNLRKLMGKQQWKDISLLVKRALDNPDILPVLQDKLVDKGLDKCSTMFDRYYDSLYNYRSFNTNIQGLRRLRVSNTIERLNAEIKRRTKKIGAFPSDDSAMRLAGSIMMDINEEYVTGRKYINMEEINRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N480</accession>
    <name>A0A1V0N480_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N480"/>
    <dbReference type="STRING" id="74969.FAD_1067"/>
    <dbReference type="GeneID" id="84217667"/>
    <dbReference type="KEGG" id="fai:FAD_1067"/>
    <dbReference type="OrthoDB" id="2305at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02068">
        <property type="entry name" value="radical_SAM_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051198">
        <property type="entry name" value="BchE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43409">
        <property type="entry name" value="ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43409:SF7">
        <property type="entry name" value="BLL1977 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding" evidence="8">
        <location>
            <begin position="14"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="194"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="532" mass="60285" checksum="40040F8E8EF3B5A2" modified="2017-06-07" version="1">MSLRAVFVRPSNRTGSAYLNKWGFLPAPLGLLALAGEIKRIPDSEVKIIDMEADDISLDDAISQILDFKPDLVGITLHATAAHNNAGYIARGVKKAKPDTVLVAGGHHATFLPEELIEAGFDISVLGEGDETIYDIAMAIMENRSFNQINGIVFRDDGSIKRTMPRKLIQDLDTLPMPPLELLDPSKYTFKVFGTDDRVMCLETSRGCPYGCDFCSVTPTWGNTWRNKSNERIIKEMENAKSYGYNWIFFTDDIFIVEPNVKHREALFDMILEKNLNTSWIVQMRVDVTSRHPELIEKAAKAGMSISFLGVESGSEEILKKMHKGEFTPQSAQAVKILSGNDIVVIVGMMVGAPYERYRDLRSTVRFSRELARAGADALQFSIYTPLPGTRIFDEALEKKSLFTLDWDRFDVLTPVMKTHVGPVLDQMVQFYASYSFYIYKFLRGKITGLQLAGKKKKLIDTGTKFIVDMMPEYLRSIAQFPRHLLETYDMYWNSKKNGFIGKEGHEELVSNSNKIIYDMGKKKNVYYMIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N481</accession>
    <name>A0A1V0N481_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142441.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N481"/>
    <dbReference type="STRING" id="74969.FAD_1069"/>
    <dbReference type="GeneID" id="84217669"/>
    <dbReference type="KEGG" id="fai:FAD_1069"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052962">
        <property type="entry name" value="AA_Transporter_AGT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47547:SF1">
        <property type="entry name" value="ASPARTATE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="27"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="558" mass="61185" checksum="59F7D06C021FDC18" modified="2017-06-07" version="1">MENSNTMKHNIIKRKPRLKKDLTFNQMLMVGLVGAFGNGALFGTVAMITIAGPEAILAFILGAAIYSLIGLTYMELGVTYPEAGGPTRYSIYTHGRWTNIINAMSDIIWYLFIPPVEVISIIAGINYFDPIFLASSGAPTYIGVALGLALMLGLIPFNYYGIKQFGKSSLYTGAVKIFFYLSMSLGLVFFAFDYANFYKYGFAPYGVAIPLFSIMPYAMYDFGAIRVIPDLAEETNNRSKMPRAIGMVLLFETLIYISVAFAITMGTNWSLIGVIPGNFLGVQAAFHGNNPFFLLSKPFPFVFIAAVITGVLTPFVTGYIYLGSGTRVLFSMGRSGYVSNKLKNIESKHSIPLWSLIVFAVVGVVLVFVTAPVPSIYTFIDDATAAGYIGLITNPIALMVTRRQGITKKKDMVRGMSIIAPLATAGSALIVFWTGWPSEPYAVILIAAGAVLFGALSKVKIGAKNALWYVFFIGFATFMVATSHDGLTSAVFPQYFSYIQGTIITFIVGLFVIYPLGVLSGFKKQFIHKDFTEQLYTKEGEADWKDSQNSKQEAKEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N491</accession>
    <name>A0A1V0N491_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="4">PEPC</shortName>
            <shortName evidence="4">PEPCase</shortName>
            <ecNumber evidence="4 5">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ppcA</name>
        <name evidence="6" type="ORF">FAD_1044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>oxaloacetate + phosphate = phosphoenolpyruvate + hydrogencarbonate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEPCase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="4 5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N491"/>
    <dbReference type="STRING" id="74969.FAD_1044"/>
    <dbReference type="KEGG" id="fai:FAD_1044"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01904">
        <property type="entry name" value="PEPcase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007566">
        <property type="entry name" value="PEP_COase_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02751">
        <property type="entry name" value="PEPCase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14010">
        <property type="entry name" value="PEPcase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006677">
        <property type="entry name" value="UCP006677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="503" mass="57947" checksum="CE1F7258BAE5BCB6" modified="2017-06-07" version="1">MSTQHPDNALMPEWSSNKNIITNEDEIEEAYIAYKKLGIQEVMWDAEGKDVDTHVIRKLFAKDRIFFENSKIGQDIFLTYRVPNPLIEGAERKILNETLNSIPLNYDVSNRIFNNGIAPIFEVILPFTTDYRSMLNVVKFYEKCVVGAQSINLYDNVYSKDVTGEVLPGKINLIPLIEDKDSIFNIEHIVKEYHRVISPEYMRIFIARSDPAMNYGMIPATLLAKYAASKMDQISEDTGMSVYPIIGAGSSPFRGNLGPANIKRALSEYDQYYTFSIQSAFRYDYNDQEVKDSIKLINKHTPQKAEFIDIETEKIIKGIVGTYSERFQKIIEDIAQPINDITFYLPKRRERKLHIGLFGYSRSTGKASLPRAISFVGALYSIGIPPEILGIASLSSLPESSQVLLKKLYRYMEQDIKASAQYFNYESLDYLKEIWRVSDKTLDMIREDIKYVEDNIGIPTETSYNVQKHNLYTKLLLMAFKNRKFEEVKSYIYELSLLRKFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4A6</accession>
    <name>A0A1V0N4A6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142426.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4A6"/>
    <dbReference type="STRING" id="74969.FAD_1060"/>
    <dbReference type="GeneID" id="31676559"/>
    <dbReference type="KEGG" id="fai:FAD_1060"/>
    <dbReference type="OrthoDB" id="6161at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="163"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="359" mass="41261" checksum="85F9610F32DDE953" modified="2017-06-07" version="1">MYSNDELFKKINHIEFYVSSAKTWSYFMERGLGLDLKAYSGLETGNRAKSSYVLSKGDINLVFSSSMEKHSEINDSISLHGDGVRDISLEVDDIEFTKKHLESRNIKVSSIKEEKDDNGKIRKAVMQTYGDTIHTMIEKGDYKGFLPGYREEDTHASDTGIYKVDHVVGNVYEGEMDQWVNYYIKNMNFSQLVTFDDKMIRTDYSALRSKVVKYNDNIVFPINEPAQGLKKSQIQEYLDYYNSQGVQHIALKTDNIIETVSKMKENGIQFLPTPESYYDTLTERVGNVDEDIEELKKLNILVDRDDDGYLLQIFTKPLTDRPTVFFEVIERKGAKSFGAGNFKALFESIERDQAMRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4F6</accession>
    <name>A0A1V0N4F6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase mutator family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4F6"/>
    <dbReference type="STRING" id="74969.FAD_1111"/>
    <dbReference type="KEGG" id="fai:FAD_1111"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033543">
        <property type="entry name" value="transpos_IS256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217:SF7">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="350" mass="40727" checksum="FBCAAE37942EC965" modified="2017-06-07" version="1">MNEEAEEQINASRYERNSNRKDYRNGYKQRSLLTTDGKVILDKPQFRETSFHTAVFDNYSRVEKSVESIILESYLSGVSTRSVNKVIKSLGIEVSPSYVSSLSSRLDKTVNEFLERKIDGEYKFIYIDGTYLKIRNNGRYRNKAIYICVGINSDGYREVLGARIYDSETEIEWELFFDDLKDRGLNGVEMVISDGNKGIREAVKQSFPGSSWQYCHVHFMRNLRKSTGKQQWKFLSLLIKQALDNPDILPLLQDKLFDRGLDKCSTMFDKYYDSLYNYRSFNTNIQGLRRLRVSNTIERLNAEIKRRTKKIGAFPSDDSAMRLAGSIMIDINEEYVTGRKYINMEEINSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4G3</accession>
    <name>A0A1V0N4G3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Drug:H+ antiporter-2 family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142483.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4G3"/>
    <dbReference type="STRING" id="74969.FAD_1118"/>
    <dbReference type="GeneID" id="31676615"/>
    <dbReference type="KEGG" id="fai:FAD_1118"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17321">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="7"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="566" mass="61579" checksum="EED15ED4AC152138" modified="2017-06-07" version="1">MQEKWIALSNTTIGQLMATINTSIIIVALPSIFVGIHLNPMQASSFPYLLWLIMSYMIVLSVLLVSIGKLSDIFGRVKIFNLGFLIFTIGSILLYIAPGTGYTVALELIIFRIVQAVGGAFIMANTFAIITDNFSPKERGFAISINSVAAVSGVSIGVVLGGILSTIYWRDIFLISIPIGVFGTLWSFLKLKDVRERAARHIDIPGNILFAVGLIILLLGVTYGITPYKNNPMGWTNPLVISALAIGAIMLVLFPFVENRVKGPMFDMRLFKSRNFSISIFTAFVSAMTMMGLMYMLTLIFQGIWLPIRGYRYAVTPLWAGIYMLPLPIFMGIFGVLSSKLADRFDARWLTTIGLFISGFALLALVALTYNFSYVFLSIVISIFGIGYGIFNVPNLTVAMSSVPADERGATSGILNTMRNTGYAASIGAFFSILLLGLSLTYPGSITHGLTVENASSLVQYFNNIPPTEILFSTFLGLNTVKDVISTVPAGVISGLPSGVMDTISGHIWFPETIAPAFMTSMHDVFYVGFGASIIAGLASLFRTPSDGDNEAKVRDKDAPRNNRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4I3</accession>
    <name>A0A1V0N4I3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Class II aldolase/adducin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">L-fuculose phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1173</name>
        <name evidence="5" type="ORF">HLB00_05395</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000179">
        <property type="protein sequence ID" value="NOL60269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143167.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4I3"/>
    <dbReference type="STRING" id="74969.FAD_1173"/>
    <dbReference type="GeneID" id="31676671"/>
    <dbReference type="KEGG" id="fai:FAD_1173"/>
    <dbReference type="OrthoDB" id="18709at2157"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050197">
        <property type="entry name" value="Aldolase_class_II_sugar_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789:SF0">
        <property type="entry name" value="3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789">
        <property type="entry name" value="FUCULOSE PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="218" mass="24078" checksum="90BE1C90531D0C74" modified="2017-06-07" version="1">MLYSEEREIVLNACREMVSSNLTVGSWGNISLRAKDGNIVITPSGTNYNKSNAEDMVITDIDGKVIDGKLKPSSERLMHYEIYKNRADVMAIVHTHSIYSSVLAVTGDGIPPVTEDTAMLLGNRVNVSRYALTGTMELARYVVEGLELNNATIMKNHGAVSVGTDMERAIIASQVLEKSARIFVTAKMIGEVNILPPEDVIKLRGMSEGYLNQWKNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4I5</accession>
    <name>A0A1V0N4I5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1176</name>
        <name evidence="2" type="ORF">HLB00_05410</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000179">
        <property type="protein sequence ID" value="NOL60271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148285708.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4I5"/>
    <dbReference type="STRING" id="74969.FAD_1176"/>
    <dbReference type="GeneID" id="16024404"/>
    <dbReference type="KEGG" id="fai:FAD_1176"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="282" mass="30328" checksum="D3749EE7E533A483" modified="2017-06-07" version="1">MATKIVVIIIAAAIVAPAAYFAYEYYSKSNVPSSIQPFQYIPGNSTVISTVHTNGTEYYLYMDGGSIGIVANISAISQVDPNLTASNSPAAVSGSGTAGLFSGSNVKTITYDHVTVYEIQNINVSGILQNMLNVSLKNTNTTANIFAYDTSGNFIVIGEQKAINESISAHLSSRDAVSFKGYMNDSSNISLYYRANNTIPTISYITMNSTSNKTYFNISPVNSNDLQVDKFLIQTAISNSNVSREIGNNYTITISNSQIHLNIDKGYTSLPAVLKTLNIGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4N0</accession>
    <name>A0A1V0N4N0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable phosphoheptose isomerase</fullName>
            <ecNumber evidence="9">5.3.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sedoheptulose 7-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmhA</name>
        <name evidence="11" type="ORF">FAD_1210</name>
        <name evidence="12" type="ORF">HLB00_05930</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27489"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:60203"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="EC" id="5.3.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SIS family. GmhA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.28" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000200">
        <property type="protein sequence ID" value="NOL60371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142613.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4N0"/>
    <dbReference type="STRING" id="74969.FAD_1210"/>
    <dbReference type="GeneID" id="31676709"/>
    <dbReference type="KEGG" id="fai:FAD_1210"/>
    <dbReference type="OrthoDB" id="64625at2157"/>
    <dbReference type="UniPathway" id="UPA00041">
        <property type="reaction ID" value="UER00436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008968">
        <property type="term" value="F:D-sedoheptulose 7-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001061">
        <property type="term" value="P:D-glycero-D-manno-heptose 7-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00067">
        <property type="entry name" value="GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004515">
        <property type="entry name" value="Phosphoheptose_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050099">
        <property type="entry name" value="SIS_GmhA/DiaA_subfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30390:SF6">
        <property type="entry name" value="DNAA INITIATOR-ASSOCIATING PROTEIN DIAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30390">
        <property type="entry name" value="SEDOHEPTULOSE 7-PHOSPHATE ISOMERASE / DNAA INITIATOR-ASSOCIATING FACTOR FOR REPLICATION INITIATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="29"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL60371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="182" mass="19504" checksum="DC9B20CB5B92853A" modified="2017-06-07" version="1">MDLEQYKNEGIKARKNIDISQIKSIASGIINSFRNNGKLIVFGNGGSAADAQHFVAELTGHYMKERKALPAIALTTNTSALTAIGNDYSYNDIFSRQVQALCKKEDYVVGISTSGNSKNVVAGIEEANSIGAFTLGFTGKSGGKLAGICSDVFHSDSDITPIIQEIHITAIHMICAIIDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Q1</accession>
    <name>A0A1V0N4Q1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1211</name>
        <name evidence="10" type="ORF">HLB00_05935</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000200">
        <property type="protein sequence ID" value="NOL60372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142615.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Q1"/>
    <dbReference type="STRING" id="74969.FAD_1211"/>
    <dbReference type="GeneID" id="84217806"/>
    <dbReference type="KEGG" id="fai:FAD_1211"/>
    <dbReference type="OrthoDB" id="116110at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050201">
        <property type="term" value="F:fucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042352">
        <property type="term" value="P:GDP-L-fucose salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052203">
        <property type="entry name" value="GHMP_Kinase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="HddA/FKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014606">
        <property type="entry name" value="Heptose_7-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463:SF0">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036406">
        <property type="entry name" value="Hept_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="7">
        <location>
            <begin position="75"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="8">
        <location>
            <begin position="227"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL60372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="322" mass="36253" checksum="487DB879EBD064C2" modified="2017-06-07" version="1">MIITKTPLRIGLVGGSTDIPEYYRNYGGLLLSAAINKYIYIIVNKKFDHKIRVSYSSTEIVDTVDQIKHPSVREAMKLLDIDGGIEILSVSDIPSTGTGLGSSSTFLVGLLNALHAYKSEFASREQLAREAIEIERNVLQEPGGMQDQYMAAFGGINMLKFNENDSVYVNPVTLNYEKLEKLKDNMSLLYTGIGHNSGGIHKNIRGEISEHLDDYRKMKEYTMDFYHALYDMNIERLGKLLDQNWHSKRALYKEISTPVVDEYYSKALSLGAYGGNLIGAGGGGFLVFIVEAKDKHKLRELGLREIDFDFDFEGSRIIYFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Q4</accession>
    <name>A0A1V0N4Q4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="7">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="7">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">folD</name>
        <name evidence="10" type="ORF">FAD_1214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="7"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142621.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Q4"/>
    <dbReference type="STRING" id="74969.FAD_1214"/>
    <dbReference type="GeneID" id="31676713"/>
    <dbReference type="KEGG" id="fai:FAD_1214"/>
    <dbReference type="OrthoDB" id="9455at2157"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054993">
        <property type="entry name" value="FolD_Thplmales"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041156">
        <property type="entry name" value="FolD_Thplmales"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="2 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="8">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="9">
        <location>
            <begin position="136"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="281" mass="31029" checksum="45C7248378AD6079" modified="2017-06-07" version="1">MLLDGKVVASEKMERLKSEIKGIIEKYGIEPELKLIQVGNDPASTIYANSKIKRGTKLGINVTLEKFDNITMDKLVDYIKDANANPRINGIMVESPLPPPLNFQEVVDNISFYKDTDGMTSFNQGNLYTKNEMIAPATARAVVDILEYYKIQPGNACIINRSAVVGRPLAMLLLNRDYTVTLCHSKTVDIKRIARENNVLVVAIGKPDYIDESYVTSESTVIDVGINYSGNKISGDVNFDSVSNKAKNITPVPGGVGIVTATDIFENFLNGMKYQIKEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Q7</accession>
    <name>A0A1V0N4Q7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1212</name>
        <name evidence="3" type="ORF">HLB00_05940</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000200">
        <property type="protein sequence ID" value="NOL60373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142617.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Q7"/>
    <dbReference type="GeneID" id="84217807"/>
    <dbReference type="KEGG" id="fai:FAD_1212"/>
    <dbReference type="OrthoDB" id="372183at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="268" mass="31122" checksum="0508EFCB6A91DF58" modified="2017-06-07" version="1">MNSDYSRYIMDNIFDFFQYPENYDRAIINAALGKMECAGKNLLFNGVKVKPDFQCTDENMLGFFLANLPLMFNERGNREYKLPPKLEKLKTDTEELISMQKFNELATLELYLLLEMAMRCAYSKWLGNKIVISRYGMDNIVLENYDYRRLKLYIRLNHLGRTDIKVNGDIFPGSENALLGWATKFMDRPTQLMFRLSLNVRNLLAHGENEWYLFPVLPSVPLAANAAGKLLYEIKPGMEIKNNGYKMAHTGNGRNTKRPTFYHGINKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4V0</accession>
    <name>A0A1V0N4V0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940560.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4V0"/>
    <dbReference type="STRING" id="74969.FAD_1285"/>
    <dbReference type="GeneID" id="84217880"/>
    <dbReference type="KEGG" id="fai:FAD_1285"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4V8</accession>
    <name>A0A1V0N4V8_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">FAD_1305</name>
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        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="12"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="EMBL" id="ARD85172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="84" mass="9545" checksum="3386CBCB5C4AF3F1" modified="2017-06-07" version="1">MVLFDPTSSGLSFDLCFILNPSDISLFIFLILLAIYSLRYQIYSIYTSICINQINLTIALYSLHIPELLLCECVFALFNTINAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
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                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
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            <end position="478"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="481"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="488" mass="53058" checksum="2DEFEB0EB2E120C5" modified="2017-06-07" version="1">MSNKTYMENIDKGDITRIVALMAFAGTLIVYVETMIVPAIPVFITFFNTTYNNVSWILTAYLITGTVAAGIFGKLGDVFGKRKVFLILSLIYAISVSMGGFATSLDELIAIRIIQGIGFGMYPLAYAIINDVVPRSRLALAQGLMSATFAVGAGMALVIGAYITEAYSWQWSYHAIAPVAFALFILSYFFLKDNTAPAKEKIDFAGVAIMASGLVMLIFGLSEGNTYGWLSPLILFSFIFSIAAFYAFIKYELASRYAFIDMHLLKRRNILIANFVGLLTMAGMYFLFFTVPTLLQDPAPSGFGKSIFTSGLIMLPATILAMVFAPVAARVTDARGPKISILIGLSVSFIAFILLILDRSTILDIIEAATVLGTGFSFVLVGIINLLLISTPKSKSGEATGMNTVFRELGMTIAPALGGTYETMYSVRVIIGLIPYRFNGLPFIPITYGFPSATAYNFTYITGIIFLLFAVLLTTLIVEKKGDNNENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N507</accession>
    <name>A0A1V0N507_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carotenoid biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142858.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N507"/>
    <dbReference type="STRING" id="74969.FAD_1368"/>
    <dbReference type="GeneID" id="31676860"/>
    <dbReference type="KEGG" id="fai:FAD_1368"/>
    <dbReference type="OrthoDB" id="70482at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419">
        <property type="entry name" value="SLL0814 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419:SF1">
        <property type="entry name" value="SLL0814 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27306" checksum="81FE6F6AE0A1F14C" modified="2017-06-07" version="1">MKTEWLIAYAYLASGIVMLIAYIFTHIYDLSVFMEVIFIPFYFYHSIKFKGANFTLKFFAASYILAFFIEFSGVHTGIPFGRYIYSSILGPELLGVPVAIPFLWSSLLYFSWLAGRGKIVTSSILMVAIDLSFDPRFSIHLWHWAVPGIYFGVPLTNFAGWFIASISIFAVLLLILPGSSKFSINALIFYTLLGLFQCIEDAVVALYLPALISAVIFVCIFAVLYYSHEISIRKNKKLQAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N509</accession>
    <name>A0A1V0N509_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N509"/>
    <dbReference type="KEGG" id="fai:FAD_1360"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="80" mass="9745" checksum="7FCA0028E2047D68" modified="2017-06-07" version="1">MAINLSHKIKKRKISNKTFIPIFILFIIIGYLYYYNIFNYKNFYLTILLDVSYLILLGDAIDRYLDHIRKKWQNSSKNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N512</accession>
    <name>A0A1V0N512_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N512"/>
    <dbReference type="KEGG" id="fai:FAD_1321"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="71" mass="8495" checksum="5B26FF924A345F1B" modified="2017-06-07" version="1">MNRHLEPFKNLPLSIRIIYYVLLIYGFISLFVYFYLIYMGDAGKYVSILTINRWILTISVALAVLYRIMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N538</accession>
    <name>A0A1V0N538_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="9 11">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Archaeosine biosynthesis protein QueC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PreQ(0) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">queC</name>
        <name evidence="12" type="ORF">FAD_1346</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>7-carboxy-7-carbaguanine + NH4(+) + 2 ATP = 7-cyano-7-carbaguanine + 2 AMP + 2 diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="9 11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142830.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N538"/>
    <dbReference type="STRING" id="74969.FAD_1346"/>
    <dbReference type="GeneID" id="84217958"/>
    <dbReference type="KEGG" id="fai:FAD_1346"/>
    <dbReference type="OrthoDB" id="6532at2157"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="QueC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00364">
        <property type="entry name" value="7-cyano-7-deazaguanine synthase QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="7-CYANO-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914:SF1">
        <property type="entry name" value="7-CYANO-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="239" mass="26849" checksum="4D66FE10AA5D368E" modified="2017-06-07" version="1">MANDKAVILISGGLDSPTVLAYALDKGYEVYPVSFDYGQRHIRELQSSEDICNYYGVKLKKIKIDMTQIGGSALTDKIDVPERGLENIEKEIPVTYVPARNTIFISLAAAYGETIKANSIFIGANAIDYSGYPDCRPEFFNAMEKTLNLGTELGITEGFRIMVPLQYLTKSDIVKLGRKLGVPYRLTWSCYNGREKACGKCDSCLLRLKGFMEAHDFDDIEYEAYPEFYSEYLKSNGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N539</accession>
    <name>A0A1V0N539_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allantoate amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142875.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N539"/>
    <dbReference type="STRING" id="74969.FAD_1398"/>
    <dbReference type="GeneID" id="31676890"/>
    <dbReference type="KEGG" id="fai:FAD_1398"/>
    <dbReference type="OrthoDB" id="35906at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006771">
        <property type="entry name" value="PRK09290.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="218"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="416" mass="45447" checksum="09114BF51E23FAE6" modified="2017-06-07" version="1">MERIKKMLIEQGSIGRENGKAISEYKELTINDGVTRPAGTDSDKSTRDYFVDLCKKNGFDPFVDIFGNIFVTLNGSNPDLGKIMMGSHLDSVVQGGMFDGAMGVFSAFEVLLRLKESGYRNNRDIVAAAFTGEEGSAFHQPMLGSNGFTGKISKANLWALKNRDGVDFKSAMQRIEYLGDSEFPGKPEYYLEYHIEQGPVLEEKGKEIGVVTSITGQCVLSVEVNGIQGHSGTTPMEMRSDALVRAAGIIAMIDKIAREASKKYNNHSVGTVGELSVEPGRFNVIPGHVAMKIDLRSEHSESLAYMKKKVLEELETKRNGVNIKYSIVAEVEPSIMSDKVMDAIRASIKSLGFSSMEMPSGAGHDTIPMSKIAEAGMIFVPSIKGLSHTPLEWTDFKDVENGLEVLLGAVKNLDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N549</accession>
    <name>A0A1V0N549_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142884.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N549"/>
    <dbReference type="GeneID" id="31676903"/>
    <dbReference type="KEGG" id="fai:FAD_1411"/>
    <dbReference type="OrthoDB" id="55603at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046057">
        <property type="entry name" value="DUF6015"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19479">
        <property type="entry name" value="DUF6015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="116" mass="13803" checksum="B5B1CDA1BABB0D1B" modified="2017-06-07" version="1">MTVSREELFKAIDNIYGRKGMSKKDSEDLCDFILSFFGYEDYIIDNVLSAAERDVFYNLEEYGIVTTHREEINIVHGKAWRINQWYLDKAKINRLAKEEKKEDSEKNIYDSIFKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N557</accession>
    <name>A0A1V0N557_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mandelate racemase subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142887.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N557"/>
    <dbReference type="GeneID" id="31676906"/>
    <dbReference type="KEGG" id="fai:FAD_1413"/>
    <dbReference type="OrthoDB" id="42605at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03316">
        <property type="entry name" value="MR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="396" mass="45064" checksum="B2027C04EA1374F0" modified="2017-06-07" version="1">MSKIKDIEVIEIGEPTGNSSSPWGSLLLLVKVVTDDGYEGWGEAPTELMALSVYEEIKEVARKFIGEEVTDISKNIERVYREEYWLSISMQTTAALSAIEMASWDIFGKINNLPVYKIFGGKVNEKVRAYANGWYDNCVTADDYFKKIEITHSLGFGAVKFDPFMDAFDNLDKKHLDNAEDIIKQIRGKYPDLDILLECHGRFNANSAIAAANRLEKYNLFFMEEPVHPDQIEGLKRFRKHTNVKVALGERILNKNILMTYLKDDLVDVIQPDISNFTGLMEGHQAAGMARTFGVEVAYHNAYGPVQNQASLNLDFTIPNFLIQESFEKFWPDWKKSIIKKSNFRLNNGYFEIVDNIPGLGFEINEDIIEKMQVHTMGPYDKNQLGWAVKGTTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N569</accession>
    <name>A0A1V0N569_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795587.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N569"/>
    <dbReference type="STRING" id="74969.FAD_1414"/>
    <dbReference type="GeneID" id="31676907"/>
    <dbReference type="KEGG" id="fai:FAD_1414"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="62" mass="7347" checksum="A50B8C4D2F3EC43D" modified="2017-06-07" version="1">MGQTTENVGYTRNRNYNTAMRLKTIAYNIIVILNRGIKEKPKEIMKIAIFENIRHFIKHKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N586</accession>
    <name>A0A1V0N586_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bluB</name>
        <name evidence="5" type="ORF">FAD_1404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142879.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N586"/>
    <dbReference type="STRING" id="74969.FAD_1404"/>
    <dbReference type="GeneID" id="31676896"/>
    <dbReference type="KEGG" id="fai:FAD_1404"/>
    <dbReference type="OrthoDB" id="53069at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050627">
        <property type="entry name" value="Nitroreductase/BluB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026:SF90">
        <property type="entry name" value="IODOTYROSINE DEIODINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026">
        <property type="entry name" value="NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="221" mass="25504" checksum="7BE85CACCCB56238" modified="2017-06-07" version="1">MDVYEAIKKRRDVRSWFSDKHIDNSSLGRILKAGNYAPSVGLSQPWNYILIRDIETRKKIKAVVEEKRMDFYNSLPDEKKIKFQNIKIEGILESDLNMAVTCDVSRKGPDILGRATMPEMSEYSVVLSIENMWLAARAEGIGMGWISFIDPDMVKKILGIPESIKLVGYLAVGYLSEDHDIPELEEKKWEKRLDVSNFVYMDKWGEKPDPETIDKLKNSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5B5</accession>
    <name>A0A1V0N5B5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">Y</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
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            <end position="73"/>
        </location>
    </feature>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
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        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="368" mass="41605" checksum="A9E43160E40D992F" modified="2017-06-07" version="1">MNVEAFRIIEPVWVLIIGILISIIPYLTEKSIIFGVRVPTDKINSDTVRKMKKIYVSITFILTIILTVLTYLLSSYLLVITFFMPLFMVLVEFMVYLPEHYSLERIKRDEQWEFNASSVTGVFNVEDGKKFPWFFTLPGILVLVSLFVTGILDYKSIPERFATHYNASGIANAYSTKSIESVFILGFISIIITIMMILIAYVIARTPLKTDNASPHGTERVVIYQERMVYLTLLTPVFINSSLLIGSFGEWGIIKENVFLILIPVFLLIIFVIAISVKTGQLGSNIKIPESKGPENTIPDNSVSDNRNDDSLWKAGVIYWNKNDPRIMVPKRFGVGYTINFAHPAGKVILVLIIAIPVIIVISVLFLH</sequence>
</entry>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="74969.FAD_1461"/>
    <dbReference type="GeneID" id="16024691"/>
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    <dbReference type="OrthoDB" id="74167at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="166" mass="18943" checksum="D22BF946FC1BE181" modified="2017-06-07" version="1">MFENKISGATVIIDGSNVALYGHKDSDKKTAVLGNILEVIRKLKELKASEIITICDANIRYIIDEKDKFNRMLANKKLILSPSGIKADTFILDYAREKNCLIVSNDKFREYRDNDWVNKNIDNITLGFIFVGGDVMLEPVNGVKSGKKNKVDKKQSGWWHFFKNKQ</sequence>
</entry>
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    <accession>A0A1V0N5H2</accession>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="16024818"/>
    <dbReference type="GeneID" id="31677040"/>
    <dbReference type="KEGG" id="fai:FAD_1549"/>
    <dbReference type="OrthoDB" id="9573at2157"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChsH2 C-terminal OB-fold" evidence="1">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="149" mass="17212" checksum="698D5C301607A9C5" modified="2017-06-07" version="1">MAGKKLMKIDPAVVEWNYNTEYRHSYAQDSPFFIALGKNKLLGSRCPECGYKYGTYRKYCMYCGAETEDIELPLKGKIHSFTTCYYSGESFRNDVPFTLVLVEFPGIDSLFMSRLYADDTGKIKIGMDIIAKFKKFQDFTVNDVYFVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5H8</accession>
    <name>A0A1V0N5H8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferripyochelin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="74969.FAD_1478"/>
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    <dbReference type="GeneID" id="31676971"/>
    <dbReference type="KEGG" id="fai:FAD_1478"/>
    <dbReference type="OrthoDB" id="10940at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF29">
        <property type="entry name" value="GAMMA CARBONIC ANHYDRASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="170" mass="18216" checksum="368A75FEED13DC23" modified="2017-06-07" version="1">MIKVGKGLYVADTAVIIGNVTVGDNVTIMDSAVIRADQNSIKIGDNSNIQDNATIHVDLDCETVIGKNVSVGHNAIVHGAIVDDDVLVGMGAIVLNKAHLRPGTVVAAGTVIPENFESDGNCMIAGVPGKVKRTGEQYFTMAHLNSLEYLKLNKDFREGKYEIMKGNRHE</sequence>
</entry>
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    <accession>A0A1V0N5J7</accession>
    <name>A0A1V0N5J7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5J7"/>
    <dbReference type="STRING" id="74969.FAD_1573"/>
    <dbReference type="GeneID" id="31677064"/>
    <dbReference type="KEGG" id="fai:FAD_1573"/>
    <dbReference type="OrthoDB" id="372195at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="29"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="313" mass="34639" checksum="39077B35BFBEB2CE" modified="2017-06-07" version="1">MSELENEINEQKTIFSNSIKRIKDNVNAACDLISNKNPIFIIGSGTSYHSALYLNSMLDMVSINSRAVQSSQLKYIINNSDYKNGLIIAFSQSGESKDLIDAIESTSGTKFTVIGITNSSKSKLTELSDVFISLNAGAEKAVTATKSFTTSLLASIIIRDTINNTETDFAGLENTITDILNNRKIKEISKSITDNVIVLGDGLNYTIALEGALKLRETANIIGEGFPFREYLHGYIETLDKNTTVICIGNRPDKEISEYTDNIILLDDYISSSINSELFPIYYAIMLQLLAMHSALNRNLDPDRPEKLHKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5P4</accession>
    <name>A0A1V0N5P4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin--NADP reductase</fullName>
            <shortName evidence="5">FNR</shortName>
            <shortName evidence="5">Fd-NADP(+) reductase</shortName>
            <ecNumber evidence="5">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 reduced [2Fe-2S]-[ferredoxin] + NADP(+) + H(+) = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ferredoxin--NADP reductase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886758.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5P4"/>
    <dbReference type="STRING" id="74969.FAD_1626"/>
    <dbReference type="GeneID" id="16024893"/>
    <dbReference type="KEGG" id="fai:FAD_1626"/>
    <dbReference type="OrthoDB" id="27340at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01685">
        <property type="entry name" value="FENR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022890">
        <property type="entry name" value="Fd--NADP_Rdtase_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0274">FAD</keyword>
    <keyword evidence="1 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="332" mass="35901" checksum="D76B5276A3D4D447" modified="2017-06-07" version="1">MDEYDLVIIGAGPTGLFATFLAGLRDIKSVTLEALDYTGGQIPELYPEKMVYDVQGIPKINATELRDKMYEQAKLFDGEIKLSSKVTDIIPDNDEYIIEVNGVKEYKCKAVLIATGIGDFTPRKIGCPGEDEFKGKGVDYTVKDITKFKDMVVAIVGGGDSALDYADELSGTAKKVYVLHHSEKFKAAEKTLDAVMNNKGISLMMNTSVTEIKGDSKIREISTINEKDKTTGSIKVDALVIAIGHVGKANVFKSVNIETSKNGRTILVNNEFQTNLKGIYAVGDGATAAGEPVHPIIAIDGANAYIAINFIKKYLTPNATMFGGHSSSLNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5R5</accession>
    <name>A0A1V0N5R5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886777.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5R5"/>
    <dbReference type="GeneID" id="16024911"/>
    <dbReference type="KEGG" id="fai:FAD_1646"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="75" mass="8659" checksum="550CD70FB26989C5" modified="2017-06-07" version="1">MNNTHNNKEENKISKKKSIKLGIIILLLFVIVELIAVAYDISHINILLYIFIIGTIVYIVVVIYLVKNRHNILNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5V0</accession>
    <name>A0A1V0N5V0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142994.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5V0"/>
    <dbReference type="GeneID" id="31677135"/>
    <dbReference type="KEGG" id="fai:FAD_1647"/>
    <dbReference type="OrthoDB" id="384567at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="303" mass="33532" checksum="EA0C120BED366768" modified="2017-06-07" version="1">MKQKYVALVAVLIATMFIMIAYSSANTNYINNINDAKSNNNYVKLGNITFMNNFIDSNNGTIIPANINKTSINNIYNYNNNDIKNNSITAYQYNYTKSNNSNYLLQYYNNSTIKYTIAFTEKFKDYKVEIADIIANENNNKISYIYANIVPINSSKILLGNEFTLNYKGTYSNEMKSLIGDVKLVAFNYMFSGNSTLNKFGIEYSYIAIAMNTMLGFTNNNVKNIVVDKTSAIAIDWSWGCIVSITILVVELMGVVAMLGGLALSTGITGGAAIALFILGLSLSIGLIGYQTYLIGNACYGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5X9</accession>
    <name>A0A1V0N5X9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5X9"/>
    <dbReference type="STRING" id="74969.FAD_1645"/>
    <dbReference type="KEGG" id="fai:FAD_1645"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="120" mass="14455" checksum="3436D0F966BB5515" modified="2017-06-07" version="1">MILRQQYVFCYIHYILYEFICFHFISVSGGDHTVYMWDKWGLKVNKYNTNYKKGNCFKTYHTFPTLLRLLNIDRYAGLVLYFMIHYLNLMFNLSFVYIVQSYNGINHTQKQPRGHGVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Y8</accession>
    <name>A0A1V0N5Y8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143037.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Y8"/>
    <dbReference type="STRING" id="74969.FAD_1703"/>
    <dbReference type="GeneID" id="84218323"/>
    <dbReference type="KEGG" id="fai:FAD_1703"/>
    <dbReference type="OrthoDB" id="55620at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054581">
        <property type="entry name" value="EncFtn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22277">
        <property type="entry name" value="EncFtn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="11349" checksum="3450973812EE3A20" modified="2017-06-07" version="1">MPMYETENSLDEKTKDMSRARQSLIEEMQAIMFYDERLDASKDPVLKEVIKHNRDDEKEHFSLLLEYLRRNDPELDRELKEILFSKKELKELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N614</accession>
    <name>A0A1V0N614_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-rhamnose mutarotase</fullName>
            <ecNumber evidence="2">5.1.3.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1711</name>
        <name evidence="2" type="ORF">HLB00_00100</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.32" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000005">
        <property type="protein sequence ID" value="NOL59240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143045.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N614"/>
    <dbReference type="STRING" id="74969.FAD_1711"/>
    <dbReference type="GeneID" id="84218331"/>
    <dbReference type="KEGG" id="fai:FAD_1711"/>
    <dbReference type="OrthoDB" id="56621at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062192">
        <property type="term" value="F:L-rhamnose mutarotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="100" mass="12031" checksum="11C3D3725838750C" modified="2017-06-07" version="1">MRYFFKLSINPADKELYISRHQNIWPEMLEELKKAGIRNYSLFLKGNDVYGYWECDDFEATMRIINKSKINEKWQESMKGIITGRDDIIPSPYEEVFHMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N646</accession>
    <name>A0A1V0N646_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">16S rRNA aminocarboxypropyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143052.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N646"/>
    <dbReference type="STRING" id="74969.FAD_1719"/>
    <dbReference type="GeneID" id="31677210"/>
    <dbReference type="KEGG" id="fai:FAD_1719"/>
    <dbReference type="OrthoDB" id="7441at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="164" mass="18778" checksum="97AA47AE1A78B3CB" modified="2017-06-07" version="1">MEKIFYVYLSQDDPKKSTMKKLERYGLAIEIPLNKIYNKLYLTPYSDNFLLNSNRILFEDKGIVVIDGSWNRINTIENIKGKNGKKLPLLLPVNPVNYGKPGKLSSLEALAAALYIMGYSELAGDVISKYSWAQNFIKTNINPLNDYMKCNSDEECIQVQDSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N648</accession>
    <name>A0A1V0N648_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940571.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N648"/>
    <dbReference type="GeneID" id="31677254"/>
    <dbReference type="KEGG" id="fai:FAD_1763"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="55" mass="6607" checksum="38A4C8B2D2E46036" modified="2017-06-07" version="1">MAIRQFLYFFSILVYNLWILINLIRRIYGLSHIILTDFLIAMGNRKWKTIMNSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N665</accession>
    <name>A0A1V0N665_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="13">IMP dehydrogenase</shortName>
            <shortName evidence="13">IMPD</shortName>
            <shortName evidence="13">IMPDH</shortName>
            <ecNumber evidence="13 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">guaB</name>
        <name evidence="22" type="ORF">FAD_1784</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="13 20"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143087.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N665"/>
    <dbReference type="STRING" id="74969.FAD_1784"/>
    <dbReference type="GeneID" id="31677274"/>
    <dbReference type="KEGG" id="fai:FAD_1784"/>
    <dbReference type="OrthoDB" id="21361at2157"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000003">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 13 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4 13 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 13 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="97"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="13 14">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13 14">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 16">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 17">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 17">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 17">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="335"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="358"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="382"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ARD85623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="485" mass="52185" checksum="9C892DDBFA6E55F7" modified="2017-06-07" version="1">MFREKFQNITEGYTFDDVLLKPLHSSIEPKNANVSSKFSRHISIGIPIVSSPMDTVTEESMAIAMARYGAIGVIHRNMSANEQVEMVKKVKKEESIIIRDVFSIAPDTPVNVARTLMKTKNIAGLPVVASGKLIGILTKRDLEFSESEGTVKDIMTKDVITADENVSIEDAKFILYKNRVEKLPLVDSKGRLVGLITAKDIKTREKFPNASRDEQGQLMVGAAIGAYDIDRAINLENAGSDFLVIDTAHAHNKNVLSSLKKIRNAIHIDIIAGNIATAEAAEDLISLGVDGLRVGIGPGSICTTRIVAGVGIPQLTAISDVADVASEHGIPVIADGGIRYSGDMIKALAAGASTVMLGSLLAGTEESPGTEMIINGRKYKAYRGMGSIGAIKAGKSDRYEKLGTNEFIAEGVEGSVPYRGKVSENLFQFVGGIKTGMGYLGAENLEELKKKAVFIKITNSGLRESHPHDIRIVSEPPNYQNSGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6D9</accession>
    <name>A0A1V0N6D9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886956.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6D9"/>
    <dbReference type="STRING" id="74969.FAD_1807"/>
    <dbReference type="GeneID" id="16025086"/>
    <dbReference type="GeneID" id="31677297"/>
    <dbReference type="KEGG" id="fai:FAD_1807"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="291" mass="31250" checksum="7917EB5D7E93775F" modified="2017-06-07" version="1">MNKKKLIIGVLIAAIFVMVSFAPVTNATNNTDQRVNVVTSDISAQPHASNLNGKQINVVKYNDSVNMLSNRIYMNMAFSVTNNTGNNQHITEHGKFGNVSVFESGNRIYLNMTIIPNNKINKVPGDCSNIYYKFPKNHEAALYVTKLPVISGASDATIIAVFGEVVSGEVGSLEGAVYYGSAAASIVLPGLLAPIVAALALDYIAIDAYASENHDPTVYFDLGASWGTKWYNFYDVGIYGEEGAFTGTADSGSSGIYIPVSIAFGDSAKYPPLSGYAPHTGVWNPNEEPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6I1</accession>
    <name>A0A1V0N6I1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="2">6.3.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purM</name>
        <name evidence="8" type="ORF">FAD_1853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
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        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
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        <property type="reaction ID" value="UER00129"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="44"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="7">
        <location>
            <begin position="164"/>
            <end position="323"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="335" mass="36973" checksum="BCE7377D69CCBF06" modified="2017-06-07" version="1">MERKIIDRKSQGEFVSNFLRQIKFKRSDFKTINSLGGFTSLIDLGNFAVSFNNDGVGTKTIIAAETNKYNTIGIDCVAMNVNDAITVGAEPIAMLDYLSLKEMDNEIARQLGIGFNVGAQIANLNIVGGETAIVPDLVKNIDISATALGLIQKDQIITGEKISDGDLIFALKSSGLHSNGFTTVRKIIKDNEIDYEDQFPGDSKRVADVLLEPTRIYVREVLDAMSIVPIKGMANITGGGIKNIARMKDMKYVIDNPFDVDNVFLRLMDMGNLSFSEMFEIFNMGMGYIVVIDPESKTDFLNIVRNRVPVKEVGHVENGSGITIPEYSVEMHGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1C4</accession>
    <name>A0A1V0N1C4_9ARCH</name>
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            <fullName evidence="4">HesA/MoeB/ThiF family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Molybdopterin biosynthesis MoeB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0017</name>
        <name evidence="4" type="ORF">HLB00_05685</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
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        <property type="protein sequence ID" value="ARD83952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="NOL60324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
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    <dbReference type="STRING" id="74969.FAD_0017"/>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
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    </dbReference>
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        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD83952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="257" mass="28825" checksum="8B06C1DA1A8013CE" modified="2017-06-07" version="1">MDMKRYSRQIVLKQIGEANQKKLLEKTILIIGLGGTGSAAAEMFSRLGVKKLILVDRDRIEITNLHRQILYDMDDLKEYKAETAAKKLQKINPDVEVEFHNSAFDSSLAYMVNSADLVFDGTDNMTTRFIINDACDKYGIPWVFTSAIEMYGEFKAIIPGKTSCYACFNSEPAELPSCEVTGVLNTVPALIASYGVNLAVKILLDYGIDGSIYFIDAFNFEINKINVERNSKCRCCHDKDYKYLGKEYSGIGKSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1E3</accession>
    <name>A0A1V0N1E3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1E3"/>
    <dbReference type="STRING" id="74969.FAD_0035"/>
    <dbReference type="KEGG" id="fai:FAD_0035"/>
    <dbReference type="OrthoDB" id="57567at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="213" mass="23748" checksum="9D95747C09CD59D2" modified="2017-06-07" version="1">MAINYYIMELSHFMLMIYILLPVAIVGLTILIAGLHMVAPDHWTPILSYSLQKKFRTGKIGTMSFSLGLIHGIFSSILSFGIAILGMYFLPEFYLKIFAVALLVFVALYIILNAMHEKKSEDSRGGEIEKSILLVSIIPDPAIVPIILIAVVYGIHFVYITLIIFVLASALALLLVTLLLSKILMKKLATFTPQKIDYLVAIILLLTTLFVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1H4</accession>
    <name>A0A1V0N1H4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Biphenyl dioxygenase, Rieske iron-sulfur component related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887023.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1H4"/>
    <dbReference type="STRING" id="74969.FAD_0012"/>
    <dbReference type="GeneID" id="16025158"/>
    <dbReference type="KEGG" id="fai:FAD_0012"/>
    <dbReference type="OrthoDB" id="6837at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD83947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="105" mass="11595" checksum="2FA36E3ABB186703" modified="2017-06-07" version="1">MWETLFKMDKIEDNALKDITVKGVPLLVSRIDGKIYVTDLYCTHEQTSLSEGFIEGCSVVCSAHFASFNLKDGKVISGPEGETGTIKDLKSYNTKIENGMIMADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1H8</accession>
    <name>A0A1V0N1H8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMP-30/gluconolaconase/LRE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141238.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1H8"/>
    <dbReference type="STRING" id="74969.FAD_0010"/>
    <dbReference type="GeneID" id="84218501"/>
    <dbReference type="KEGG" id="fai:FAD_0010"/>
    <dbReference type="OrthoDB" id="341532at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="15"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD83946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="275" mass="30850" checksum="C967B6A281FD1271" modified="2017-06-07" version="1">MLKAKLIHESPQLKLGESPIWRDGLLYYVDILNGKIYSYGENITQLHTDSIIPFIVPCDDGLIFATKESIKHLILKSGKVETIFKMKLDENIRLNDGKCDMNGVLFAGTMDMNEKDPLGALYRFDSKESKVLDRITISNGTIWNYDKKIMYYIDSPTRKIRVFNYDNRNSAILDEMESIDVSVFPGVPDGMTIDSMGNLYVAFHGGSSVIAFDSNGKVIKKIYVSAKNVDSCVFGGDDLKTLYITTAIDENGDGGNLYKIKNEISGIPSEKYKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1J9</accession>
    <name>A0A1V0N1J9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl37ae</name>
        <name evidence="5" type="ORF">FAD_0042</name>
        <name evidence="6" type="ORF">HLB00_02695</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000086">
        <property type="protein sequence ID" value="NOL59742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887053.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1J9"/>
    <dbReference type="STRING" id="74969.FAD_0042"/>
    <dbReference type="GeneID" id="16025188"/>
    <dbReference type="KEGG" id="fai:FAD_0042"/>
    <dbReference type="OrthoDB" id="372011at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD83977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="85" mass="9763" checksum="2DC21FD2BC23784A" modified="2017-06-07" version="1">MTKHTVKVGASGRFGPRYGVTVRKAWNKIYKQKISFYTCPSCKQKKVKRVANGIWECRHCSYKFAGGSYTPEYSSEIVKEINNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1L0</accession>
    <name>A0A1V0N1L0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl39e</name>
        <name evidence="6" type="ORF">FAD_0076</name>
        <name evidence="7" type="ORF">HLB00_07325</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887085.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1L0"/>
    <dbReference type="STRING" id="74969.FAD_0076"/>
    <dbReference type="GeneID" id="16025221"/>
    <dbReference type="KEGG" id="fai:FAD_0076"/>
    <dbReference type="OrthoDB" id="65887at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002316">
        <property type="entry name" value="PRK01242.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="51" mass="6219" checksum="23C3195368486205" modified="2017-06-07" version="1">MSKNKPLGKKIRLMKHVNSNRRVPGWVMMKTDRKMTQNPKRKNWRRSNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1M7</accession>
    <name>A0A1V0N1M7_9ARCH</name>
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        <recommendedName>
            <fullName evidence="1">Bifunctional protein GlmU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1M7"/>
    <dbReference type="STRING" id="74969.FAD_0090"/>
    <dbReference type="KEGG" id="fai:FAD_0090"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04181">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056818">
        <property type="entry name" value="GlmU/GlgC-like_hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24894">
        <property type="entry name" value="Hexapep_GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like C-terminal hexapeptide" evidence="3">
        <location>
            <begin position="301"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="367" mass="40993" checksum="CDA977DA039C2F5C" modified="2017-06-07" version="1">MIILSNFMSIKAVVMAGGKGTRLRPITYSIPKPVVPIAGKPCMLYLLDSYYNAGIKDVIITTGYKFSSLITSIIENRHNDQAILFSVEKEPAGTAGSVKMVSNFIDDTLIVGSGDILSDFNISDIINFHKKNKAMVTIVLTEVEDPRQFGIVEMENNRIVRFLEKPDRDQTFSHIASTGIYVIEPEILDYITTMPYDFAKDLFPELMKRNIDIYGYMGKGVWLDTGRPNDLITANQIMVEKYGKLSDGDLIKGKNIILDMAGIHNTGIEKCYIGRNIKAGDNVHIKDSALYDNENIGNNVEITNSLLMDNVTVRENTKIRNSVIMRNCVIGENSEIVDSIIAPDMDLRGKSRIYNVSLASKVIEDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1M8</accession>
    <name>A0A1V0N1M8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding enzyme</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0061</name>
        <name evidence="3" type="ORF">HLB00_07400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141276.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1M8"/>
    <dbReference type="STRING" id="74969.FAD_0061"/>
    <dbReference type="GeneID" id="84218551"/>
    <dbReference type="KEGG" id="fai:FAD_0061"/>
    <dbReference type="OrthoDB" id="385453at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="390" mass="44926" checksum="8FFCC8E08E8E4932" modified="2017-06-07" version="1">MIEAINSHVNIPDISMYSLLLRNAEVNGSRPIIIFYDKYITYSKLLKYVDSMAYQLEHRLNVRTGETIAIIMDFSPPYIISIISSIKIGARILIIDGKTDDSTINGYIDKYGIKVMIICKKFAEKAKNERIKYIVSDPNDFLTLGKALINNIRNRSYVKYGNNVLKFYEFIYSDNVPDLPEAHEPSCIMFHIENELLVFNMKSIIGETFIINYWLPKFDGKPVFYSGIDHSTPLGLIYSITLPISFSGTIVINSPASISRNACDFVVGPPSFYSQIIEKKINISGVKYCIMPFYDREIENAFHQYTDIPLITGRSDQFTLTTHMNPFDDIRAGSFGMPVNYVECMINPENELLIKTPYLPVIYENNKKKEYEWYNLHTKVKVVDNYYYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1N3</accession>
    <name>A0A1V0N1N3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887135.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1N3"/>
    <dbReference type="STRING" id="74969.FAD_0129"/>
    <dbReference type="GeneID" id="16025274"/>
    <dbReference type="GeneID" id="31675641"/>
    <dbReference type="KEGG" id="fai:FAD_0129"/>
    <dbReference type="OrthoDB" id="33250at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="102"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="337" mass="38342" checksum="C904B3F617F20471" modified="2017-06-07" version="1">MIKFGVAGIPLTSKGRTYMDSIQEVANLGLNSLEVQLLRVNVSEDPAIEYVDMYPKDVTDSIIVDVLRPDDTGNYRSIGTEKEIEEDDIVQEIFWNMARNYDELKEGSEIARELDVDISMHAPYYMDLLNGGEMAEKSLNHLRWSLLIGKAMGAKRIITHTGFYTRKKSESLKNALDIYADVAKKFSHENGYPYIGVEASGKKDLFGTQKELFYLADRIPEVEPILNFPHIHSINNGSLIDAKNFEDVVAAFAKYAKYDLYSEFGGVEYDNGNELKITAIKHGDLKFETLAEVISTSDRDMDIISMSPLLEHDAQYMELMYWRALSKKYQKKLAKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Q0</accession>
    <name>A0A1V0N1Q0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141315.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Q0"/>
    <dbReference type="STRING" id="74969.FAD_0092"/>
    <dbReference type="GeneID" id="84218582"/>
    <dbReference type="KEGG" id="fai:FAD_0092"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="385" mass="44220" checksum="9E5DA8E21EF4CAB0" modified="2017-06-07" version="1">MPQYDNQENENSISFREFSIKLNGITEIENLNIDLGWDCDVLLYSRNRNISRITGLFVFDIFNNMEPGGKLMHGGRDMVELITKIKKFRVNGNRIGILGRLLGDIFPIPPDPLDAFDPGIKISSQILDFVPYQTRIEALNAIIRREMIKLVEIREIIKNFDAAEDKLTYAIIKSQDFGVLPKYTEMYNILKSESKDRENLLAALMIGEKTGVNLADMVMLRNYYRYRLTLDGLNGEICECNVNGESCHKIHKKRESVMKKGRKDFNFMNFKVAKSYSENILKIEIINLVKSYMNITGIQYEEGIYDIFPTDANISDLYKLLTCLAFLTGKSVIIADITLNPGHATEIVEFIKRLKSIQNMACLYICTDDEVAENKNRIFDRVIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Q9</accession>
    <name>A0A1V0N1Q9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795604.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Q9"/>
    <dbReference type="STRING" id="74969.FAD_0102"/>
    <dbReference type="GeneID" id="31675614"/>
    <dbReference type="KEGG" id="fai:FAD_0102"/>
    <dbReference type="OrthoDB" id="25514at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="7">
        <location>
            <begin position="123"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="383" mass="42912" checksum="B7B572C5B99743EC" modified="2017-06-07" version="1">MLLDRINEFKGKNFAYFCKFDDERRTGTETLFVSGEEPVNVYNDAINHMNNEFAGIIKSGKNIPVIVSYDFIDDIYPDIKLKRSSWPEVSYIIPEEEFSGTYIREKEQTTIANGVLDDNELEGKIGDAIKRIKNGDLLQIVLSRRFDLDNYDPLYVAKKFLKNDKSLYVYYYKFGDLEVIGSSPENLLSVQNGTITIYPVAGTRKRGKSESEDKDLENDLKNDQKELLEHRMLVDLARNDLGRICYPGSVDVLSSMEIRKFASVMHIVSTVSGKLEEYAPGNILRSVFPAGTVSGAPKKKAITLINGYEDMPRGAYAGALGIIGNNGMDLALLIRSLFKSKNENYTQAGAGIVKDSVPSSEIAEMYSKILTVTGGLYEKNINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1R9</accession>
    <name>A0A1V0N1R9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="15">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rtcB</name>
        <name evidence="16" type="ORF">FAD_0098</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for tRNA splicing and maturation. Acts by directly joining spliced tRNA halves to mature-sized tRNAs. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14 15">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="15"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141330.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1R9"/>
    <dbReference type="STRING" id="74969.FAD_0098"/>
    <dbReference type="GeneID" id="31675610"/>
    <dbReference type="KEGG" id="fai:FAD_0098"/>
    <dbReference type="OrthoDB" id="9887at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="12">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="325"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="398"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD84031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="475" mass="52441" checksum="E892888CB8AF8FEA" modified="2017-06-07" version="1">MVQVKKIDDYRYEIPRTGNMRVPGTIYISQDLLGNFTDDEPIKQVMHVASLPGIVKSSMAMPDIHLGYGFPIGGVAAFDYDDGIISPGGVGYDINCGVSLITTNIDYDEARDKINILLDEINKTVPAGIDYKSSFRISIDDENEILSSGIEWAYNNGYATREDIERTEENGKMLSDISGVSEKAIKRGKNELGTLGAGNHFLEMDRIESIMDEAKAKKFGINNKNNLAIMVHTGSRGLGHQVATDYLMRLNEEDSSIKSEDDRQLISAYIHSRTGQDYINAMNAAANFGFVNRQIITYKIRKAFEKIFGEDFEHLGIETLYSLAHNMAKAEMHNVDGNKRKLMVHRKGATRALPAYASSGYFNETGHPVIIPGNMGGPSYVMVGMPGNEEITFSSSCHGAGRVLSRKRANEQFNAEDVEMELKSRGIYLRATTKKAIIEESPGSYKNIDEVVRVINGAKIAAPVARLMPVAVMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1T1</accession>
    <name>A0A1V0N1T1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141380.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1T1"/>
    <dbReference type="STRING" id="74969.FAD_0153"/>
    <dbReference type="GeneID" id="31675664"/>
    <dbReference type="KEGG" id="fai:FAD_0153"/>
    <dbReference type="OrthoDB" id="380524at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="73" mass="8543" checksum="9C9276BDDF9067F3" modified="2017-06-07" version="1">MDNLNKEQTENVNVNKAPLKYGYEDIDMEIGDDDLEYNQVGILKNPYAVAIIVIAIWFSLWLFLQVFLGRWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1W6</accession>
    <name>A0A1V0N1W6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="11">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ctaB</name>
        <name evidence="12" type="ORF">FAD_0156</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141383.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1W6"/>
    <dbReference type="STRING" id="74969.FAD_0156"/>
    <dbReference type="GeneID" id="84218645"/>
    <dbReference type="KEGG" id="fai:FAD_0156"/>
    <dbReference type="OrthoDB" id="131615at2157"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="288" mass="32484" checksum="A4C8A58A7199262F" modified="2017-06-07" version="1">MSKITNFMKITKLEITILIDLVAITAFILVPGSFSHPLILFLLILSGTLASMSASMFNNIYDMDIDTKMKRTRSRSSTLNPGTRGLIFSIAAAMIVVSFVLSSVFINLLTALFIFGGFLSYVFLYTIFLKRRTTWNIVIGGIAGGFPALAGWAALTNSVSFTSLFLAFLVFMWTPTHFWNLSINNVDDYKASHVPMLPAIVGIKKTEFWIVINTVILIFYSLIPLLVPSIKLGLPYIPIAIIMDIILLYYVLKPAFRLYDKKYFRKAFGFSNMYLMILLLVIIIYPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1X0</accession>
    <name>A0A1V0N1X0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rps5</name>
        <name evidence="12" type="ORF">FAD_0179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887184.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1X0"/>
    <dbReference type="STRING" id="74969.FAD_0179"/>
    <dbReference type="GeneID" id="16025327"/>
    <dbReference type="KEGG" id="fai:FAD_0179"/>
    <dbReference type="OrthoDB" id="38155at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_A">
        <property type="entry name" value="Ribosomal_uS5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047866">
        <property type="entry name" value="Ribosomal_uS5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003125">
        <property type="entry name" value="PRK04044.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="221" mass="23951" checksum="253DDBC04DA31DCC" modified="2017-06-07" version="1">MDEEWIPKTELGRLVANNEIQSIGDALHTKLPLQEYQIVDYLIPDLQDEVINIERAQRMTDSGRRMNYSITAVVGNGNGYVGIGRGKAKEAAPAIRKAINNAKTNIIEIKRGCGSWECGCGRPHSLPFEIIGKSGSVVVKLKSAPQGVGLAVGDVVKIILKMAGIEDAWGFASGHTKTTVNYALATFDALKKTVSMKMNSQINLTTPIYVGGIEHDSNNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N208</accession>
    <name>A0A1V0N208_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141398.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N208"/>
    <dbReference type="STRING" id="74969.FAD_0197"/>
    <dbReference type="GeneID" id="84218685"/>
    <dbReference type="KEGG" id="fai:FAD_0197"/>
    <dbReference type="OrthoDB" id="8042at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR00212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="285" mass="31675" checksum="D0C73F1AEA5F1D18" modified="2017-06-07" version="1">MPVTIGTRNSKLALIQANSVKDALESRGYEVNIKSYTSAGDSNKNIPLYRMSSTGVFVDELNERVLKGEIDLAVHSAKDIPSNIQKGLEITAVTGRDDFRDVLISRTPLEEMTAGSVIGTSSMRRIRQAMTVNPEITVSDIRGNIDTRISKYTEKKYTGIIIAMAAYKRMKLDIEHFILSEEQFLPAPNQGIIAIVGKSNSTASIISGEINDRETYRDMKNERFIATSLNLGCSMPVGILSKDGKIKTRFYSLDSDEHRDMVFSAENLDSVVEHIKEGISDYGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N257</accession>
    <name>A0A1V0N257_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141463.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N257"/>
    <dbReference type="STRING" id="74969.FAD_0296"/>
    <dbReference type="GeneID" id="84218796"/>
    <dbReference type="KEGG" id="fai:FAD_0296"/>
    <dbReference type="OrthoDB" id="42357at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050545">
        <property type="entry name" value="Mycobact_MmpL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33406">
        <property type="entry name" value="MEMBRANE PROTEIN MJ1562-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33406:SF6">
        <property type="entry name" value="MEMBRANE PROTEIN YDGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="796"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="828"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="379"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="864" mass="95125" checksum="E32050474688CA2F" modified="2017-06-07" version="1">MSLTQKIRKKRILVVIIWVVILLLMIPAVLGYSGFLTYSTTTNVSSHAESTIANKIVSEKYQQNSTLIVVINSTYYQNLSSSDTAKSILAFQSSLNSSSLKYFSGSQSIYSAYMTAINKEFNKSNIENIRDAYSGINATSHDIFSFPSNFYAHWEINSFANSSIYTAAESSGYNNSNSYEHDFISSINNTTGSPFGRVSSAIQNSYQAIKTPYTNIVYSTFTINNYSNSGSLVNATAFYLSENGIYINNYMASAAIHSNDPGKYYLYHYGLLNVPSYLKKEYMAGDIGIINVIFTVKSGTDIVGGKTAGELATPAVENVAGKDLNHALITGNGAISYETSKETAKAGFAFGLIFIFLAIAIFITLVSWKSAILVFMISGIALLLGYTSEYLSGLLFHHVSFIVNYTLTAVILGVSADYFVFIVSRYRESLRAGKTEDEAFGEAVSKSGKSVTISGLTVAFSLFTFYFIPGFRSWGTSLLFAVIFTIILETTLLPAAMSFFGKKLFMAYGMKKIGKDDVKNSIFYKIAGRSVRHKILVIAIIGILGASGIYGFLAVPTSYNFNTGLPQSLSSVHAETEINNNFGDSHLYPVYDVVNLSKTTNANSTLLSDAKYLFNTSGVTSVYGPFAAGKNVTDNNITSYIINGKYAVFTVYLKYNPYSKNAINTVTEMRSSNNFIVGGLTSTIIDEKNANSRIYTELEVLIVAVIGLIIGISFKSWKYPFISLIGVFFSVAWTTSILYFISTYLLHEALIYLIPIILFIILFSLGNDYTVFIISRIREEQKEKKNDEAIKHGIGYSGKVVTSLGLILAVSLGSLSIIPVAFLEELGIAFIISLLIDTFIIRNIYFPAMISILFRDKNHNHKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N266</accession>
    <name>A0A1V0N266_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LD-carboxypeptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Muramoyltetrapeptide carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0275</name>
        <name evidence="9" type="ORF">HLB00_06435</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000224">
        <property type="protein sequence ID" value="NOL60469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141445.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N266"/>
    <dbReference type="STRING" id="74969.FAD_0275"/>
    <dbReference type="GeneID" id="84218773"/>
    <dbReference type="KEGG" id="fai:FAD_0275"/>
    <dbReference type="OrthoDB" id="55610at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07025">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="entry name" value="LD-carboxypeptidase A C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="MURAMOYLTETRAPEPTIDE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237:SF2">
        <property type="entry name" value="MUREIN TETRAPEPTIDE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="LD-carboxypeptidase A C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="LD-carboxypeptidase N-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="LD-carboxypeptidase C-terminal" evidence="7">
        <location>
            <begin position="180"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL60469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="310" mass="34783" checksum="2335AAE4838A9A67" modified="2017-06-07" version="1">MENRVKPPKLQPGDEIRVIAPASAPDMIKLSRGISKLKKLGYKVTVGKNIKKLNQRNDLAAPAKDRAEELMSAFRDDNVKAIFCARGGYGSIHILSLLDYEAIRENPKIFMGYSDITALHLAINRNSNLITFHGPMVASDVDDISKPSFKEFLGILSGKSDEINIYRDRLIKYIIPGKTEGYSMGTNISLVASLLGTNYIPETTNRIFFIEDTDVTSGDIDRYFFSMKLAHIVEQFNGFVFGDFKAIFDKEEPMPSIEDVVQKFMNEINKPSLYGAPFGHGEEQMVLPLNARIGISDEEPYMELKENVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N283</accession>
    <name>A0A1V0N283_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Winged helix-turn-helix transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N283"/>
    <dbReference type="KEGG" id="fai:FAD_0297"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29614" checksum="90343F893AB8451E" modified="2017-06-07" version="1">MHMDEMDSSILVNIIKNPRQTLTELGSKLELSEQVIYYRLKNMKFKSIIEKYFLRINYEKLGMKSVYLAFENDAPYPEPVNAKIMCLEKITVYGLSGKEEELNDRIENLCSYLGKPFMRYEAPVSGKKFELSALDKEILDELSKDPLASAVNIADRLERKSSTVKRRIDYMLENGIISIIPKINLRMVNIVLIAIFSSTIEEFSSIIDSRLLIAYSPGSGFAITITDSLESAKKLIDNIRKKDKNAEVMVVYDYDFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N292</accession>
    <name>A0A1V0N292_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdenum cofactor biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887327.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N292"/>
    <dbReference type="STRING" id="74969.FAD_0307"/>
    <dbReference type="GeneID" id="16025473"/>
    <dbReference type="KEGG" id="fai:FAD_0307"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034471">
        <property type="entry name" value="GDGT/MA_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056488">
        <property type="entry name" value="Zn_ribbon_HMPTM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045702">
        <property type="entry name" value="rSAM_GDGT_ether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306:SF1">
        <property type="entry name" value="7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23545">
        <property type="entry name" value="Zn_ribbon_HMPTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00385">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01100">
        <property type="entry name" value="methyltransferase_(Class_D)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="141"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="608" mass="69762" checksum="07866E56D9E4FE11" modified="2017-06-07" version="1">MVLTEERNKSEVRLANDFEISRNAPFKTVDEFLKGMGHLITDDMLVLRVTESLCPLCADEEKFDQMRIPAIVYEEGGEVDLIKECAEHGITKEKYWEDYDMYEEAKKYQDKEGTKILNPNVAIYADKIICPTHCGLCVKHKSHTGLGNVVITNRCDLSCWYCFFYAKENEPIYEPSLDQIRLMLRRMRNEKPVGANAVQITGGEPTLRDDIIDVIRIAREEGYEHVQMNTNSVRAAYDPDFVKRARDAGSNVVYTSFDGPTPRSNPKNFWEIPMALEHYKQAPMGVVLVPTVIGGINDQYLGDMIKFAKSNMDVVRGVNFQPVSLVGRMSDRARARQRITIPGAIKKIEQQLDGAVGREDFFTVPATTDVSNFVAALKGHPTYKLSIHFACGMGTYLFIDNDKIIPVTRFVDVKGMFEYLSELGDDIKYAKWQAPKKVESVTKLLLHLKKFVDYSKAPEGFKLKDMVYNAFTEGDYHGLKAFHYKSLFVGFMHFQDPYTYDVDRVERCDIHYAMPDGRVIPFCAFNVIPELYRDSTQRKYSIPANVYEQKTGFDLKKDKYFRKYTVEEKKRIISFYERSLGRNLTSKEIGLDLDKDEIPMISSVNPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N295</accession>
    <name>A0A1V0N295_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141460.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N295"/>
    <dbReference type="STRING" id="74969.FAD_0293"/>
    <dbReference type="GeneID" id="84218793"/>
    <dbReference type="KEGG" id="fai:FAD_0293"/>
    <dbReference type="OrthoDB" id="115601at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="228" mass="26545" checksum="60BAF179CEC8F401" modified="2017-06-07" version="1">MAGNYVYNKDDEADDYNERGISYFNVTQYPDAVKEFTKAINLIKTDPDYYINRALAYYSMHMYNEAIKDCKSAIALSADRGDYHNTLGSIYDDMNRFDDALAEFDAAIKIEDDVPDYYYNRGNVYWRKGDKDLALEDYNKAVYLNSADPVFLYKRSQIYTEMEKYEDALGDLDDCIKLARNPEYYKDEANIYIKMGNKEKALQAVDNALKNSPENISLKELKSRIEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2A2</accession>
    <name>A0A1V0N2A2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0303</name>
        <name evidence="3" type="ORF">HLB00_04270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000147">
        <property type="protein sequence ID" value="NOL60049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141474.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2A2"/>
    <dbReference type="STRING" id="74969.FAD_0303"/>
    <dbReference type="GeneID" id="31675812"/>
    <dbReference type="KEGG" id="fai:FAD_0303"/>
    <dbReference type="OrthoDB" id="57134at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08556">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211:SF14">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="246" mass="28765" checksum="50AF70C52A1210B8" modified="2017-06-07" version="1">MNIRDYIKSNFVVVGHRGLPSEYVENTIESFENAFKFTDIVELDVHLSSDNEVYIIHDFNLNRLASIDKDIENIESAEIDRIMVRGQNIPKLRDLFKLFRDKYFLVELKTVHDDGYLVKNELTKYTLQVVESMGMEDHVCIISFDPYALRRAGELSRTIMLGFDYDQHSEKYIGKIDCKDLKSMGVSLFLPEYKKEYMKKFKEIQDDGYFVVPWTVDREEDGVFIANSGLNGYITNMVDRMSKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2B0</accession>
    <name>A0A1V0N2B0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0304</name>
        <name evidence="3" type="ORF">HLB00_04265</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000147">
        <property type="protein sequence ID" value="NOL60048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887324.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2B0"/>
    <dbReference type="STRING" id="74969.FAD_0304"/>
    <dbReference type="GeneID" id="16025470"/>
    <dbReference type="KEGG" id="fai:FAD_0304"/>
    <dbReference type="OrthoDB" id="195008at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Winged helix-turn helix" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="106" mass="12809" checksum="55C58D1803DA1A8C" modified="2017-06-07" version="1">MGQNQLETVISVENGKEKRVLVRTYMGRPSKLHENQMIALKNCVENKKVCTVHEIQEYIEEEFNVTYSSKEVREILRKFNLTYYPLLRKYTYPSYYNEKIIKKFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2C5</accession>
    <name>A0A1V0N2C5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2C5"/>
    <dbReference type="KEGG" id="fai:FAD_0319"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="145" mass="17296" checksum="8E116CFECC4BC31C" modified="2017-06-07" version="1">MVSKKEEDYDSGIQMYFMKEYDLAELLDRLMKVDEPHMEEYKKMVELIKSLENYIITGEKAADFSFLEKIEGERGWANDYKILSSENRAAHVAFRACRKTIEVMYYYRLVSRKEGFSGRFNPENFRALLLMRDILYKRSSDLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2E6</accession>
    <name>A0A1V0N2E6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0382</name>
        <name evidence="3" type="ORF">HLB00_00620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000016">
        <property type="protein sequence ID" value="NOL59342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887403.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2E6"/>
    <dbReference type="STRING" id="74969.FAD_0382"/>
    <dbReference type="GeneID" id="16025549"/>
    <dbReference type="KEGG" id="fai:FAD_0382"/>
    <dbReference type="OrthoDB" id="56905at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="74" mass="8517" checksum="2CC5430670C602B8" modified="2017-06-07" version="1">MISQTWEKMKKSSRYMIVTGIVFLIISLPTFLDYNMFPTINSNIGPHQLSSWISFFFSFVGFVLLVVGFGEEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2E7</accession>
    <name>A0A1V0N2E7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0356</name>
        <name evidence="3" type="ORF">HLB00_08485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000318">
        <property type="protein sequence ID" value="NOL60859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141532.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2E7"/>
    <dbReference type="STRING" id="74969.FAD_0356"/>
    <dbReference type="GeneID" id="84218854"/>
    <dbReference type="KEGG" id="fai:FAD_0356"/>
    <dbReference type="OrthoDB" id="386671at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="157" mass="18935" checksum="CFF05B7A3C2F2CE6" modified="2017-06-07" version="1">MGINIIGLFLDYRTSFKFFYPVVVLLFLTLVVTFHSRKYKNKEMDEIIRDANLKIEDTHFLKELKLIKSGDFSSYLMEIDNDMSHVTLLLKHYKLMVRKYHKYNAKSKNSSRIMRKHAAKMKDAYLQYILDDYESIKKIKMNMINTEVYDEWKKQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2E9</accession>
    <name>A0A1V0N2E9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha glucosidase alphaGluFa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">alphaGluFa</name>
        <name evidence="1" type="ORF">FAD_0354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2E9"/>
    <dbReference type="STRING" id="74969.FAD_0354"/>
    <dbReference type="KEGG" id="fai:FAD_0354"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="508" mass="54871" checksum="802C306789F419BE" modified="2017-06-07" version="1">MVFAGANIPYPGYNPTDHLISGKHPISNVSEVPKNFTLSGNVSNSNNNLPLSGTITVSNSTMSRTFNTSSNGSYNITLPQGNYSISSSIPGFQNYSSTINLDSNKTQNISTPPATTIGNGINQVPGSTNVSTLVPYLNNSIMSGGLNTDNITGTFDKNITIDLGKKLNNTQFVVLMKLDGAVYSYNWVTNGSGMAKLFLKYSGNYTMSAYTLYYNSSVIHYNTANNDTARFNMTERITFISSVILQSAVPLHDNSSVANSTLTVKGGVFSVPSLSVNSNLTGTYYKYEVPVGFYNFAYSNAHYVSKNFGVDVTGNSTVNKTIDPYLISINIRNNTGNTFNYTLGSTFYSGNGIHMATSGITTLLVFHDGKIVYDNTILLTSANPYYQLNLTISNKNLTFNGIETDSTNLSIVYSGNVTSNFYIASLEFENFSTSATNGMIIISGAASGSYPLDSGLYTYNMSQSLPTSAGNLTIKLVYDNDSKVSTDGRMTVEVYGYNISTLGNYITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2F1</accession>
    <name>A0A1V0N2F1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141521.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2F1"/>
    <dbReference type="STRING" id="74969.FAD_0353"/>
    <dbReference type="GeneID" id="84218851"/>
    <dbReference type="KEGG" id="fai:FAD_0353"/>
    <dbReference type="OrthoDB" id="26949at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01942">
        <property type="entry name" value="ribokinase_group_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="entry name" value="putative 5-dehydro-2- deoxygluconokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054998">
        <property type="entry name" value="NucKin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041164">
        <property type="entry name" value="NucKinThplmales"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="296" mass="32972" checksum="4E26DF9292564B08" modified="2017-06-07" version="1">MKFLAFFGHLNIDVTLSVPSLPSPGQATGVKALREKFAGTAGNFAYVANALGLKFDLYSAVGEISHEKYIANLKKVGINTEHVDIMKEENGPICYLPSDGREQIAYMFQGPMNNWEASKHFEYGNYTFLNIGTGPVKEYMKILDREKKAKVVFDPGQEIWYTYNKESAEYMVNHSNMIIMNRKEFYHLLELLNTDSAAVYKTVNNIIITEGEKGATLIENGESTLMPGIKPDRIADTIGAGDSFRAGLFTALSNGYTLKDSVSIGNITASKAIENNINEFNLNFQDILKLFKTIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2F4</accession>
    <name>A0A1V0N2F4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841659.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2F4"/>
    <dbReference type="STRING" id="74969.FAD_0392"/>
    <dbReference type="GeneID" id="16025559"/>
    <dbReference type="GeneID" id="31675901"/>
    <dbReference type="KEGG" id="fai:FAD_0392"/>
    <dbReference type="OrthoDB" id="28720at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL/LppC-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00481">
        <property type="entry name" value="YbhB/YbcL family Raf kinase inhibitor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF1">
        <property type="entry name" value="PEBP (PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="150" mass="17169" checksum="3A038D0F617DFC8C" modified="2017-06-07" version="1">MELRVIGMSEGRRIPDKFTCSGKNHSPKIEIHDRNETGYYFIVMNDPDAPSGLFTHWIIYNIPAGIVTLEENIGNKEITEEGYYQGLNDFGELGYGGPCPPRGDGDHRYFIKIYRTDEAVSRKKIDAEHAYEILDKLSPEAEFYALFSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2G2</accession>
    <name>A0A1V0N2G2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-related sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141536.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2G2"/>
    <dbReference type="STRING" id="74969.FAD_0360"/>
    <dbReference type="GeneID" id="31675869"/>
    <dbReference type="KEGG" id="fai:FAD_0360"/>
    <dbReference type="OrthoDB" id="135517at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050229">
        <property type="entry name" value="GlpE_sulfurtransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43031">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43031:SF1">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="104" mass="12104" checksum="B162FA459533777B" modified="2017-06-07" version="1">MVLNIDADEVSEMAEKNECVIIDVREQFEYESGHIENSVPIPMYDIFNNISLVEKYRDKKIVLVCSSGHRSYYTGKFLEENGITNVYNLYNGLYGWEIEDKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2I7</accession>
    <name>A0A1V0N2I7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Prefoldin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GimC subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pfdA</name>
        <name evidence="8" type="ORF">FAD_0398</name>
        <name evidence="9" type="ORF">HLB00_05075</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prefoldin alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887419.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2I7"/>
    <dbReference type="STRING" id="74969.FAD_0398"/>
    <dbReference type="GeneID" id="16025564"/>
    <dbReference type="GeneID" id="84218896"/>
    <dbReference type="KEGG" id="fai:FAD_0398"/>
    <dbReference type="OrthoDB" id="10045at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL60206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="133" mass="15107" checksum="4B76EB314390AE32" modified="2017-06-07" version="1">MAGENELVEQIEYLKNLLETIDSRMNLLLKTLEESNDTLALLKDTDYEKSKDVKISIGSGLFSKAALDTSKIIVPVGSGVFIEEEKEKTIKRMEENIQSLQDTYNNLLKQKQSAQNNYDALMYSVQRAQEGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2J4</accession>
    <name>A0A1V0N2J4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940590.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2J4"/>
    <dbReference type="STRING" id="74969.FAD_0395"/>
    <dbReference type="GeneID" id="31675904"/>
    <dbReference type="KEGG" id="fai:FAD_0395"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="158" mass="17754" checksum="7F0D52F52116EB48" modified="2017-06-07" version="1">MESGKYLYYGPVAGFISAIFEAIMFYLFDIAASLPPGYQFTAIGSRLLHISGFYGTLYGMLLHFVVGTVVGIVAALISYYVIALRIKTVKSGLFIGILAGFLVLLVFSLPVNILLLHLYVYEKYYLPSTAFYYSMHIFYGAVWGIFLGYFISRQRKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2J8</accession>
    <name>A0A1V0N2J8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein translation elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141620.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2J8"/>
    <dbReference type="STRING" id="74969.FAD_0465"/>
    <dbReference type="GeneID" id="84217048"/>
    <dbReference type="KEGG" id="fai:FAD_0465"/>
    <dbReference type="OrthoDB" id="30874at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03696">
        <property type="entry name" value="SelB_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF11">
        <property type="entry name" value="SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTu-like" evidence="1">
        <location>
            <begin position="154"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="299" mass="33608" checksum="F9C44700282BDCE9" modified="2017-06-07" version="1">MESYSIFCYNASDYIKEIAKVGTNSDIQLYHRKDENIIMTFIEPIKYPEKVSSLTDSIYPSDIAIIKVSSINKDLGEVIIALDLMGKTRGFIIADEEKQPVIKKIIGNTSLKDYKFFTGKPMELIDEIKAMDIPRNGDQNLTVIDHFFKVKGVGTVALGFVLSGSISKHQKLVLSDLDREVEVRSIQMNDEDVDSAGAGSRVGLALKNIEPTDMERGMFLSDKPFEYAETIPGKVVPQTSLKLDLGDNFEIFVSDIMRFQRGKFENDHIILDKKIPVVKKTMVLSNNNMVPRIFGTINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2N4</accession>
    <name>A0A1V0N2N4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2N4"/>
    <dbReference type="STRING" id="74969.FAD_0484"/>
    <dbReference type="KEGG" id="fai:FAD_0484"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="230" mass="26666" checksum="44532F82D13D7E24" modified="2017-06-07" version="1">MKIIRNRRYEAVWLNRNIYYHVNTINIMSILPKKKPKLSKDEELEETKVKIKDLQMNLKRAIRALLKRAQSLEESRKAAQERNYNDIERGLEKQIEDVRAFTTYFDRTNILLDSISSQLDMYNDAGKAMDLIGKSEVVFQALKITPDQQASYLRSLASIKDIADNNLNSINDQVERINENLGFSENSDSPISEDELLTNFLTKRSAKSNKPAEKDDEIDAELEKRNAEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2S6</accession>
    <name>A0A1V0N2S6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887546.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2S6"/>
    <dbReference type="STRING" id="74969.FAD_0490"/>
    <dbReference type="GeneID" id="16025693"/>
    <dbReference type="KEGG" id="fai:FAD_0490"/>
    <dbReference type="OrthoDB" id="129730at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072">
        <property type="entry name" value="N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072:SF23">
        <property type="entry name" value="UPF0039 PROTEIN C11D3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="165" mass="18857" checksum="8F0916E917B43446" modified="2017-06-07" version="1">MDTGIIYRKASLDDVPYIADIWNQGIDSGNATFEIKKRDPVWTSDWLVKRDPRYVVLVAGNRNNILGWLSLNPFSSREAYRFVADISIYVENSYHGRGIGSGLLDHGIIEAKINGFHKLVLTMLRDNEIARKLYISRGFSTVGIMHEQGILNNKWIDTEIMEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Z8</accession>
    <name>A0A1V0N2Z8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141726.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Z8"/>
    <dbReference type="STRING" id="74969.FAD_0612"/>
    <dbReference type="GeneID" id="84217213"/>
    <dbReference type="KEGG" id="fai:FAD_0612"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="15"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="458" mass="50272" checksum="EA16FC89A23E4FFB" modified="2017-06-07" version="1">MENQLKSNAISLHGLIFQGMGQLSPLFTFDGIISVAAFAEGASPLAFLIGLIASLLTGNTLYQFSKRTASARGYYGYSGYSLGNHAGFITSYLYLIYQLANLIFILSFFIMIFNPAILYLTGVNVPYYYGIILVIAISIPSFYAIYKGIVPSFKSQIIINVVEIIFVVSISIIIIVTSRDNTLSVFTPISGYKNLFLGFITGSFLAYTGYGSIVPLGEEAQAPRKNIGIAIVAMLLIIGVLDLLISYALVVGFGLSNMSSFSDTVIPAFIVIKSHIGLYTSMFFLAFNFFIIYTLFNTIGTAITRNIYSMARDGYLPPAFSKLNKHNAPQNALFLLLGIFIAVGGISTYIFYSSFNVNGFLNQFIFYATISTLATLIIHMIVNSGLSKVHKNFTFDILIPSVSTIIILIALYYAISTLAFPFTYALIIMALYIIIVVVMDLSLKGKMKNINFNSAVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N323</accession>
    <name>A0A1V0N323_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0583</name>
        <name evidence="8" type="ORF">HLB00_04910</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000167">
        <property type="protein sequence ID" value="NOL60176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141703.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N323"/>
    <dbReference type="STRING" id="74969.FAD_0583"/>
    <dbReference type="GeneID" id="31676087"/>
    <dbReference type="KEGG" id="fai:FAD_0583"/>
    <dbReference type="OrthoDB" id="57556at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038730">
        <property type="entry name" value="HyfE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38601">
        <property type="entry name" value="HYDROGENASE-4 COMPONENT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38601:SF1">
        <property type="entry name" value="HYDROGENASE-4 COMPONENT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24471" checksum="E7FA7BD05B49D6A9" modified="2017-06-07" version="1">MNIIYTFIYLLAALIVVTGFYIQSNKYLRSMVLTQAFQSFIIALIAFLLGIVLRQYTFFILGALVILLRTVLVTYFLVSKIPKNKNYLYESKLPTTYYLLIDLAFIVISIFIVYSISFIHIRSHIFPDSDIILFPLLLFFQGLFVIASRRRTVAQILGYIEEENSLILLGTFILPVPIIIESSVFLDVLVLVVIFSIISIEKTEHKPVEELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N339</accession>
    <name>A0A1V0N339_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mercuric reductase</fullName>
            <ecNumber evidence="4">1.16.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Hg(II) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">merA</name>
        <name evidence="20" type="ORF">FAD_0574</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Hg + NADP(+) + H(+) = Hg(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23856"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16170"/>
            <dbReference type="ChEBI" id="CHEBI:16793"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887631.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N339"/>
    <dbReference type="STRING" id="74969.FAD_0574"/>
    <dbReference type="GeneID" id="16025781"/>
    <dbReference type="GeneID" id="31676078"/>
    <dbReference type="KEGG" id="fai:FAD_0574"/>
    <dbReference type="OrthoDB" id="27922at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016152">
        <property type="term" value="F:mercury (II) reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045340">
        <property type="term" value="F:mercury ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050787">
        <property type="term" value="P:detoxification of mercury ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021179">
        <property type="entry name" value="Mercury_reductase_MerA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02053">
        <property type="entry name" value="MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014:SF4">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE RCLA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0475">Mercuric resistance</keyword>
    <keyword evidence="11" id="KW-0476">Mercury</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14 17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="19">
        <location>
            <begin position="4"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="18">
        <location>
            <begin position="337"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ARD84486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="460" mass="50175" checksum="2524B1050D77C210" modified="2017-06-07" version="1">MSEYDLAIIGWGAAGFAAAIKASELTSNQMKIALIGTGPIGGTCVNVGCVPSKFLIEASKNYKEATKPSYRGITANANINFSEFMESLNDFVSTERNTKYADVIKNFENIDMYEGMAKFIDNNTVAVNNKDIKALNFIISTGSRTLIPEIKGLTDYYTSDTIWNMRELPGKIAVLGSGEVALELAYAFSNFGTEVHIFNRSNRILKGFDEDINNHLINALKTNGIIFHLGQNFQEIINKNGKKSIVTEAGTFDNFDSLLVATGRVPQIDKLNLKAAGISTDNGIVVDDSLKTTNPIIYAAGDCIRQSLKLETLAGKEGVIAVENMLGGSRTINMHEVPWVVFTEPNVASVGYTEAELKSKNIEYDVRTVELKNVVKANILNSYDGIAKVISGKDKKILGVHVVAPMAAEFIIEGVYLIQNGLTYDNLINAMHVFPTVAESIKIGGQAFIRDISKMSCCMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N366</accession>
    <name>A0A1V0N366_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0624</name>
        <name evidence="3" type="ORF">HLB00_04705</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000162">
        <property type="protein sequence ID" value="NOL60135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887682.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N366"/>
    <dbReference type="STRING" id="74969.FAD_0624"/>
    <dbReference type="GeneID" id="73909249"/>
    <dbReference type="KEGG" id="fai:FAD_0624"/>
    <dbReference type="OrthoDB" id="385605at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="entry name" value="NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005023">
        <property type="entry name" value="PRK06433.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269:SF17">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="83" mass="9023" checksum="F37920CB851F3A58" modified="2017-06-07" version="1">MIDTIIFFILAAIAVIMALSAISTKNLIHSSIFLLILLLMFSIIFIFLGLSFVGSIELLVYAGAVVMLIVFVLMLTGGKDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N393</accession>
    <name>A0A1V0N393_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">succinate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FAD_0717</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141840.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N393"/>
    <dbReference type="STRING" id="74969.FAD_0717"/>
    <dbReference type="GeneID" id="84217340"/>
    <dbReference type="KEGG" id="fai:FAD_0717"/>
    <dbReference type="OrthoDB" id="23539at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005037">
        <property type="entry name" value="PRK06452.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="12">
        <location>
            <begin position="7"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="13">
        <location>
            <begin position="440"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="564" mass="62689" checksum="D32F683511F25294" modified="2017-06-07" version="1">MEKKEYDAVILGGGLAGLMAANMVAAAGFTVAVVSKVFPTRSHSSAAEGGIAAYIMGNSDPNDDPDFMSYDEVKGGDYLVDQDAAELLSKKSGEIVNLLDAWGAPFNRQPDGRIALRYFGGQTYPRTRFIADKTGMALLHTLFEHSTGFKNIDFYNEYYVLDIAREGDSVNGLVAMEMKTLDPIYLKSRALLIASGGIGMMYKHSTNSYINTGDGHGIALRSGVALKDPEFVQFHPTGLYPSDILISEAARAEGAILKNNKGERFMARYAPHKFDLAPRDIVSRSMAIEIREGRGFEGGYLGLDLRHLGKKYILERLTLAYDAAKNFSGVDAAEEMIPVRPAQHYFMGGIDVDITGTNHDLKGVFAAGEAACVSVHGANRLGSNSLLETLVYGRETGNAMVEYLKSHKKIESNSDVEKLVDNAYAYIKRESGEHFGVLTEELRDIMWDNVGIFRDKDRLSQAISKIKDLRTRSRSMYVTDKSTNYNTELFNALETRNMIDVAYAMATGALNRTETRGAHFRDDFPERNDKDWMKHTITYLAGDEIKITYKPVTYTRWKPEARVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3B1</accession>
    <name>A0A1V0N3B1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF296 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0722</name>
        <name evidence="3" type="ORF">HLB00_01150</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000031">
        <property type="protein sequence ID" value="NOL59444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141847.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3B1"/>
    <dbReference type="STRING" id="74969.FAD_0722"/>
    <dbReference type="GeneID" id="84217345"/>
    <dbReference type="KEGG" id="fai:FAD_0722"/>
    <dbReference type="OrthoDB" id="179876at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34988:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34988">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="138" mass="15815" checksum="68AD6E0E21CE4E33" modified="2017-06-07" version="1">MQSNAENNIIVAKFEANEDVLSNLNILVEKYSIKTGFIDMGIGMIKNLKIGYWNINKYDELLIEDRSELVAFHGSIANDKNRFHIHIGVARKDHGLYGGHFFSGIADPLMEVKITKFDNIEFTRKYNPESTLNELEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3C2</accession>
    <name>A0A1V0N3C2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141856.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3C2"/>
    <dbReference type="STRING" id="74969.FAD_0732"/>
    <dbReference type="GeneID" id="31676234"/>
    <dbReference type="KEGG" id="fai:FAD_0732"/>
    <dbReference type="OrthoDB" id="82046at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF1">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="221" mass="24490" checksum="58607A037BC83FBC" modified="2017-06-07" version="1">MVKLILFDIDGTLMEESPTHTAAFDYVCKEIYGVDTDIESFPRHGMTDTGIMYGLLKKQGIQEVEIKAKLDIAFQALIGYVSTNLQPADYKLLDNVKNMLDAVKVNGYISGILTGNLQPIAEIRLQHAGIEEYFLTGGYGSDSIIRSKLVDYAIQRYGKNINRSEIYLIGDTPLDIKAAREASTRAVGIATGVYPITDLNGADLTLKNFKDINKLIDFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3E1</accession>
    <name>A0A1V0N3E1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Solute-binding protein family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74969.FAD_0690"/>
    <dbReference type="KEGG" id="fai:FAD_0690"/>
    <dbReference type="OrthoDB" id="57497at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.105.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290:SF9">
        <property type="entry name" value="OLIGOPEPTIDE-BINDING PROTEIN APPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 5" evidence="5">
        <location>
            <begin position="116"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1297" mass="138554" checksum="8555AC58F3013975" modified="2017-06-07" version="1">MTYNKKQKLLIVFAILVAAIFVMEPLYGNIGNNNQAPSTSISSSIPLISGASASPSSYTYPTNTSGEPGYTGGTFKLAQIGNPNNLNPFEADTVCDLYILDSIYSSATDELPNGTIIPCLATSYNVTLAPANMTTFDPMTGGNSSVAEIWTVHIRPGVQWDDWTSANADSTYVYSNSTSFYNETGIPYTHTYKEVYNASTGKFQKESNIVMKTNYVQAADFVLSWKILSESTEYDGSYIGVVNVMPVNNLTVDFYLSKPSATFVPYTLETPILPYHIWVSHDYASAGSGYWNETAATAATPANGSYNEWDLGHSGPFGGTNGEYPGLVGSGPFMMNGGYGMPVGKVFTSDYWQVYENPNYFMQYVTGKYLWTHEFIPKIFSEKVYIFSSPSSAVGALSTGKVDAIESDLSSEFVSTADQIPNVHVFEKPSTGYAYFKFNSYSADAPFNITAFRQALRYASPLAYIDSSICDGYDVPGYSILPTIDKPYSIASSVPSFTFNLKTANATIASIPGMHYKNGEWYYNGVQVTATIQSPSSSLIPQIFTGYETIASDWSSIGIHTTVESESFSTIISKLLAYSNSASSPSASYNVITLGVSGLLGDPIGDLVDDFNYTAASGSGDYEGPFSAMNVSNPYLSDLGIKEESALGVVDTTTYNLTGSQIDSLMTNLTNYANTNTSLKDTDEAIAAMQYIEDEESTMMEIGYGPTDSIAYSNSTFTGLTDVPSDMNGFWEQNLFTVHLRAKALVVAKPTAKIIVSGIANKLVYYNGEYGNITFTAINNVTLKPVANQAISITVEPSLINITSLSGTTNSKGQFTYEFKVYNANTFINTVGYNGLVSVTATVVSSISGVASGVGSVPINDLPVPVAYKVSGPTAISGTTPTYYNITIYNPATGAPISGYSYTIQTLTAAITMSNTTSNQKISYLSTYDVDCNSTSISVPVNSTYSSDNITSISGVTGSNGVISVMIAGNSTFNYTLNGNNYESYIFFGNYADAAPGAGEAPYMVLGEVTSSMNVNGYGAGEPFEIPIMLEKSMDYYNISVDKIAINGTTTELIFHVTNSTGAAVSGYNLNVTSQNVLGANRGYFIDSSSSAINPNYNLTTSCGADTGSQYSPMITLVTNSNGMAYANFTSLFYSYNATTGAISSMATPSGAILPYDEFQISVIGDGAPAVAYAVVSSNTSASVYNLTFTESGLKSGTLWYVTVGTQTESSSSSSIVFEEVNGTYAYTVGNVTGYKITKDASGSAKLSGKNASVDVTFAKKVNYTDYYIIGGIVAAIIIIGGVVYALKRKSKTPKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3F7</accession>
    <name>A0A1V0N3F7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="7">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="7">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pdxS</name>
        <name evidence="11" type="ORF">FAD_0719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141843.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3F7"/>
    <dbReference type="STRING" id="74969.FAD_0719"/>
    <dbReference type="GeneID" id="84217342"/>
    <dbReference type="KEGG" id="fai:FAD_0719"/>
    <dbReference type="OrthoDB" id="6840at2157"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Thiazole synthase ThiG" evidence="10">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="330" mass="36272" checksum="A52D9877466EF37C" modified="2017-06-07" version="1">MLDLQKLKYGDELLKRGFAKMTKGGVVMDVTNAEQAKIAEKAGAVSVMALERVPSDIRAQGGVARMSDPLKVKEILDSVSIPVMAKVRIGHLSEASILESLGVDMLDESEVLTPADPFYHINKKMYKVPVVCGARTFPEAVRRIFEGAAMIRTKGEAGTGNIIEAVRHIRTVNDGIYILNSITSDEMYAVAENISKSYTTLRNLTASDLYGADKEMPYDNVYYGMDFREISNQIFKVLKEIKHMKRLPLVNFAAGGIATPADAALMMKMGMDGVFVGSGIFKSKNPQKMAEAIVEATENYEDYKLLSDVSSGLEGMHGLDISEIEKLQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3H3</accession>
    <name>A0A1V0N3H3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP:glycerol 3-phosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142002.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3H3"/>
    <dbReference type="STRING" id="74969.FAD_0810"/>
    <dbReference type="GeneID" id="31676312"/>
    <dbReference type="KEGG" id="fai:FAD_0810"/>
    <dbReference type="OrthoDB" id="26592at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07769">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000008">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="9">
        <location>
            <begin position="258"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="489" mass="53552" checksum="9079202735D3089F" modified="2017-06-07" version="1">MAGEYILSIDAGTTNCKAVIFDRSGEITGKSSIRMVSYYPREGWVEQNPYFIISAVKKVISQAIKIAGIDPGDIESAGITNQRETTVIWNRKTGVPIYNAIVWQDRRTENVMRKMENYITVIEEKTGLRPDPYFSAGKIQWILDNVEGAREKASKGELAFGTVDSWLLFNMAGSGPHSTDYTNASRTMLYNIRKLEWDNEMLELFNIPDSLLPEVEPSLNDFGSISISPGKEIPVYAIIGDQQSALFGHAAISKGMAKNTYGTGSFMLANTGNNIPATGSLIGTIAYGLEYKKVSYAVEGSIFSAGSSIDWMKNILNVKSYDKLEEMALKAHSSNAYLVPAFTGLGSPYWDPTARGTIVGLTHSTGRNEMARMAYESVAYQTEDVLQEVKKVTPVKELKVDGGLTRSQFLMQLQSNLSGLNIIKTNTTEITATGSAYIAGLASGFWKLDQLGAMSSTERKFSPDNSSGGAHSGYFGWKQAVAISFGWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3I3</accession>
    <name>A0A1V0N3I3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEPN domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">HEPN superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0813</name>
        <name evidence="3" type="ORF">HLB00_04045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000134">
        <property type="protein sequence ID" value="NOL60005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841806.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3I3"/>
    <dbReference type="STRING" id="74969.FAD_0813"/>
    <dbReference type="GeneID" id="16026039"/>
    <dbReference type="KEGG" id="fai:FAD_0813"/>
    <dbReference type="OrthoDB" id="359241at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="135" mass="15438" checksum="D58125591B8CBD9D" modified="2017-06-07" version="1">MVTYLDEDEYARWMSNAKYTLKSAENDKSAEFYNWACFKAQQATEYAVKAYIRGTGSDSFGHSVSLLLNKAGFDKNLVNIAKVLDKYYIPTRYTDAWTEGVPEDYYTLDEANEAIANAGIIIEEVESKWKSLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3I8</accession>
    <name>A0A1V0N3I8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141898.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3I8"/>
    <dbReference type="STRING" id="74969.FAD_0743"/>
    <dbReference type="GeneID" id="84218270"/>
    <dbReference type="KEGG" id="fai:FAD_0743"/>
    <dbReference type="OrthoDB" id="110773at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053172">
        <property type="entry name" value="Tn903_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053520">
        <property type="entry name" value="Transposase_Tn903"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033579">
        <property type="entry name" value="transpos_IS5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631:SF3">
        <property type="entry name" value="ISSOD12 TRANSPOSASE TNPA_ISSOD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="128"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="307" mass="36420" checksum="8158AC1FD3F40636" modified="2017-06-07" version="1">MTPQINNKINRSIKRYWIGSNRRWEKYNESLVDRIEYLTDLSFIKDYDTLLEENNSGKIGHPYKVPDALIMYLARLRSIFNIPFRTLEGMLRSLAIIANIKSISYSEIFRRIRRIKPELNNINSKLDCIIDSTGYKITIRGDYLRHKWHRKRKGWIKLHVIISLKDVTVLSFTITDEHTHDSKAARKLLSKMKNNILRIFGDRGYDSKYIYNMFGYNAVIPPRKNASTKSRGSYARAKIVRFIKKNSMEQWKENNSYSKRWIVEIYFSGLKRVMTEIIKAKKIEYIIQELALKVVNYNIMRGMTHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3K7</accession>
    <name>A0A1V0N3K7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951104.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3K7"/>
    <dbReference type="GeneID" id="84217411"/>
    <dbReference type="KEGG" id="fai:FAD_0791"/>
    <dbReference type="OrthoDB" id="10490at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204:SF18">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="107" mass="12152" checksum="7221DA07E1DAC333" modified="2017-06-07" version="1">MTYLELKEIGSGKEFLDKYSDIMRMWTVPIMLAIERHGEAGFNQIKKDVKGINSTTLSTTLGMLEKYGLLERVIIPAKPVRVKYSLTDKGKELYKISLNLATLIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3M7</accession>
    <name>A0A1V0N3M7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD family phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0814</name>
        <name evidence="3" type="ORF">HLB00_05235</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000175">
        <property type="protein sequence ID" value="NOL60238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142008.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3M7"/>
    <dbReference type="STRING" id="74969.FAD_0814"/>
    <dbReference type="GeneID" id="84217436"/>
    <dbReference type="KEGG" id="fai:FAD_0814"/>
    <dbReference type="OrthoDB" id="31229at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF1">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="207" mass="23580" checksum="B9E85112889D580D" modified="2017-06-07" version="1">MATVSANKSIIFDLDGTIWNSIIYRIKAWQLAFKDYGIDTDPEVIRLMIGYPGSMLIKKMNARDPAIEKREEMYFEKMLPDVKFYPDVEGTFSQLRNMGFKIAIVTSSRRDMIEKINVHAEAIVTMDDVEKGKPDPEPYKKAIKIMDGTPERTIVVGDIDNDLVPAKLLGCVAVLVSHGTQKRAEHKDYEISEIGDIIKIIETLKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Q2</accession>
    <name>A0A1V0N3Q2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dTDP-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142105.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Q2"/>
    <dbReference type="STRING" id="74969.FAD_0874"/>
    <dbReference type="GeneID" id="31676378"/>
    <dbReference type="KEGG" id="fai:FAD_0874"/>
    <dbReference type="OrthoDB" id="4907at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="327" mass="37596" checksum="EBECD3E13A0979D2" modified="2017-06-07" version="1">MKTFLVTGGAGFIGSNFINYLHNNYEDYIINLDKLSYGSNLNNIKIDSRYKFIKKSIGDDITEIIDNTDYIINFAAESHVDRSIASPESFVSENINGVLNLLECIRKSKNDPVLINIGTDEEYGDTINGSFTEQDMLKPSSPYSASKAASSLLALSYFRTYGIKTMVTRTSNNFGKYQFPEKLIPKTIIRNLLNLDIPLYGNGRNIRDWIYTEDNVRAILTVLFKGKYGEIYNISSNNELENIDIVEKIFDLMGKKGNIKYVSDRPGHDVRYSIRSDKLKNLGWKPEYSFMDALKLTVEWYINNEKWWKPLIGNNTLSEEPWKLKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3T9</accession>
    <name>A0A1V0N3T9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4145 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142199.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3T9"/>
    <dbReference type="GeneID" id="31676440"/>
    <dbReference type="KEGG" id="fai:FAD_0936"/>
    <dbReference type="OrthoDB" id="57982at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025285">
        <property type="entry name" value="DUF4145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13643">
        <property type="entry name" value="DUF4145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4145" evidence="1">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="226" mass="26483" checksum="E4A518FA3027B3B6" modified="2017-06-07" version="1">MKDKPKNYNCLKQIKSAIYLSNTRGEIGRKERDLEADKLLIKYFNNCDFASIESDIISIVFIDTTTTLTQAIESYRYGQFDSSMVMIRSAIDAATYASITMEPVYDHNLKKLISINPIDGINGYKKYKKLDRRMKKITDKKFLTHNETDELLKIRNEGNFSAHYFKIKNDHFNDIIKIYETKHELPEDLPRQFTTEKDNQSNLLRAFEIITTLQNNYLKFYKIASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3U6</accession>
    <name>A0A1V0N3U6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3U6"/>
    <dbReference type="STRING" id="74969.FAD_0887"/>
    <dbReference type="KEGG" id="fai:FAD_0887"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051396">
        <property type="entry name" value="Bact_Antivir_Def_Nuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43581">
        <property type="entry name" value="ATP/GTP PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43581:SF4">
        <property type="entry name" value="ATP_GTP PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="190"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="365" mass="42501" checksum="A1A27A67B1F9EE1E" modified="2017-06-07" version="1">MNPYLIYNLSRNKYQNSIINYLSDNSSIKIDIENNKVKKLSFRKATPDQILNLLKNDLSELFNKKDEVYMGINKYIAIEKIIRNIDKNKIYQASLDSIIVLVNYSDHQIILAGESYGDLLTYSLSNLYDNYISQNAKDPTTHTSNGDIPENEYMMKHEYMITMLSYHHELSRKNSLIKYKKDNVTFIKNALNSTEHINSNQKLAPQLENTIKHDNIISNLKRFNFDSLVLDTEDGDKEIPMESMGDGFKSLIYILAKLYENESNIILIEEPENYMHPGYIRELIHYIISLANNSEIQLFIITHSQDFLYMLTSDSDLSENDIEFLKKELLILQLSRFKDNIILSNLDYNDAISDMEDLLLDLRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3U7</accession>
    <name>A0A1V0N3U7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">cas1</name>
        <name evidence="10" type="ORF">FAD_0939</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142205.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3U7"/>
    <dbReference type="STRING" id="74969.FAD_0939"/>
    <dbReference type="GeneID" id="31676443"/>
    <dbReference type="KEGG" id="fai:FAD_0939"/>
    <dbReference type="OrthoDB" id="2216at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="entry name" value="CRISPR-associated endonuclease Cas1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="entry name" value="CRISPR-associated endonuclease Cas1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019858">
        <property type="entry name" value="CRISPR-assoc_Cas1_HMARI/TNEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03641">
        <property type="entry name" value="cas1_HMARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43219">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDONUCLEASE CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43219:SF2">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDONUCLEASE CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="319" mass="37298" checksum="72AF5252F3E08303" modified="2017-06-07" version="1">MGDTYYLINSGSLFKLGDSVRFSNKNQNIDIPIETIDEILIFGNISFTTPVLKLLSDKKIPVFLYSQHGWYISSIYPENFLQSGFVLSHQAEFYNNPELRIELAKKFVLGAGKNMKRLLQRLKIGQIKLPLQEIENSRTIQELMGVEGNIHIKYLELLDTKLPDDFKIDSRTRQPPRNYINSMMSYLYSVLYGIVGAQIFSTHLSPEISFLHEPGERRSSLSLDVAEIFRPVLCDRVILKLINLKIMKKTDFIDDNGIFLNEYGKKKVLEEFENKLRETVYSASLRRKVSYRFLIRIELYKIEKHIMENKTYKPYIMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Y2</accession>
    <name>A0A1V0N3Y2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Formate dehydrogenase alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FAD_0903</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142155.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Y2"/>
    <dbReference type="STRING" id="74969.FAD_0903"/>
    <dbReference type="GeneID" id="31676406"/>
    <dbReference type="KEGG" id="fai:FAD_0903"/>
    <dbReference type="OrthoDB" id="23466at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02792">
        <property type="entry name" value="MopB_CT_Formate-Dh-Na-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.90:FF:000001">
        <property type="entry name" value="Formate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000003">
        <property type="entry name" value="Formate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.228.10:FF:000002">
        <property type="entry name" value="Formate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Formate dehydrogenase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Periplasmic nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.90">
        <property type="entry name" value="ADC-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.228.10">
        <property type="entry name" value="Dimethylsulfoxide Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF14">
        <property type="entry name" value="FORMATE DEHYDROGENASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036643">
        <property type="entry name" value="FDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="16">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="15">
        <location>
            <begin position="259"/>
            <end position="315"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ARD84795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="978" mass="110102" checksum="60E6D6268671FF8C" modified="2017-06-07" version="1">MSSGKIFIDGIPLNIKGDETILRAMMDNNIDIPHVCYNPALGAIESCDTCIVNADGKYVRACTTQAKNNMNVLFNSPDVKARETEAVNRILHNHDLYCTVCENNNGDCALHSAVDTLQVTRQKYPFTSKGYEADYSNPFYRYDPDQCILCGRCVEACQDVEVNETLHIDWSLERPRVVWDDNKAINDSSCVSCGHCVTVCPVNALMEKSMLEEAGYFTSLTRKAKYNLIEFGKDLEKPVGNGMIMKISNIEAKMREEQIKKTKTVCTYCGVGCSFTMWTKGRKILKVQPEVESPANGISTCIKGKFGWGFVNSEERLKYPLIRKNGKFVQASWDEAIDFAAKGLKKVGEKYGNESLMFIASSKGTNEESYLLQKMARQIFHNNNVDNSSRFCQAPATTGLWRTVGYGGDAGSIQDIYKSELVMIVGANTAESHPVLATRVKRAHKLNHQKLIVSDLRKNEMAERADIYLHPSPGTDIVLLSALSKYIIDQGWHDREFIEKRVNGFDEYYKSLEPFTLENASSITGIPEKQIIQTAEMIHSVKSMCILWAMGITQHSAGSDESTAISNLLVLTGNYGRPGTGAYPLRGHNNVQGASDFGAMPTYLPGYQPIKDKEVIKKFEKAWHTELPTKPGIDNVSCIENIDNDKIKGMYVVGQEIASTGPDSNKTRDSLERLDFLIVEDVFFSETAKYADVVLPASVSLEKEGTFTNTERRIQRIYQVMEPYEETRPDWEIIQGIAKSLGYDWNYKHPSEIMDEAASLSPMFHGVSYERLEGFKSLQWPMKENGEGSEYLYEDRFNFPDGKARLYPLSYRPPLKVSEEYPLHLNNGRMLEHFHEGNETFKTEGIKEKVPDTFLEISEKLAAEYKIQTGDFVRVTSKWGSIKVRALITERVSGNELYMPMNAASDDATVNLLTSYTRDPDSDTPAYKELPVKIEKLKKNGGSPLPANNSRYGKPEPQIGILVSEKWKRKDYSKLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N403</accession>
    <name>A0A1V0N403_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N403"/>
    <dbReference type="STRING" id="74969.FAD_0950"/>
    <dbReference type="KEGG" id="fai:FAD_0950"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="54" mass="6460" checksum="0387F4F777AB9F7D" modified="2017-06-07" version="1">MEKLTEYDEITTECYVKNRKNGIFKLRAFCMENSRPVVISVPEHYNFVMEVNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N431</accession>
    <name>A0A1V0N431_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142275.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N431"/>
    <dbReference type="STRING" id="74969.FAD_0980"/>
    <dbReference type="GeneID" id="31676479"/>
    <dbReference type="KEGG" id="fai:FAD_0980"/>
    <dbReference type="OrthoDB" id="25212at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43365:SF1">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43365">
        <property type="entry name" value="BLR7806 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="6">
        <location>
            <begin position="262"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="386" mass="41640" checksum="EC7F8CD7D4886900" modified="2017-06-07" version="1">MNNSGNTVYIIDSKRTPIGKRNGSLKDVHPVDLLGNLTRDTLAINKIDPHWIDDVITGCVDQVGNQGADIARNSWLSAGLPESTPGVTIDRQCGSSLQAIEFAKNGIISGDYNIAIASGVESMTRIPILSTIKDANPVTESLNLRYKMNNEWFSQAYGAELIAEKYGILREDMDFLGYTSHMRASQSRNVFQHEILPVKNNGNTILEKDEGIRDSPDLKKMNQLPPAFPNLKLVTAGNSSQISDGASIAILASEDAVEEYNLKPVAKIVSTAAVGVNPVTMLTGPIPVTKKVLDRAGMKIEDIDVFEVNEAFASVVLAWEKELNVPHEKVNVKGGAVALGHPLGATGTRIVSTMVNILNTRKLHYGLIAICEGGGMANGAIIERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N434</accession>
    <name>A0A1V0N434_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type sugar transporter, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142375.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N434"/>
    <dbReference type="STRING" id="74969.FAD_1027"/>
    <dbReference type="GeneID" id="31676526"/>
    <dbReference type="KEGG" id="fai:FAD_1027"/>
    <dbReference type="OrthoDB" id="57451at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050901">
        <property type="entry name" value="BP-dep_ABC_trans_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32243:SF18">
        <property type="entry name" value="INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YCJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32243">
        <property type="entry name" value="MALTOSE TRANSPORT SYSTEM PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="63"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="268" mass="30470" checksum="6530F1CBB7FE1C7D" modified="2017-06-07" version="1">MKLNKLLTYIVLSLLGILFVIPFIWLIVEAFSPLNNVGLTFPSYYTLKPFYSVLTNKIFINSIYEGLIQSFGGTFLSILFAIGPAYIFSRKRFRFRLPLLLGILLLTGFPVFSLLIPEYVFYVKESLYNNIIGVILFLGVLNVPIDIWILKNSFDQIPQAIEKASYIDGASNLKSMLYIFLPLAMPIMAVLIILNFVINWGNFYVPYILLSSTHLFPISVEIYSFFGAYNVQYNELAAFSIIYTIPAIILYIFSQKYMIKALSGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N463</accession>
    <name>A0A1V0N463_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type peptide/opine/nickel family transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142342.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N463"/>
    <dbReference type="STRING" id="74969.FAD_1014"/>
    <dbReference type="GeneID" id="31676513"/>
    <dbReference type="KEGG" id="fai:FAD_1014"/>
    <dbReference type="OrthoDB" id="57213at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050319">
        <property type="entry name" value="ABC_transp_ATP-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43776:SF7">
        <property type="entry name" value="D,D-DIPEPTIDE TRANSPORT ATP-BINDING PROTEIN DDPF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43776">
        <property type="entry name" value="TRANSPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="245" mass="27750" checksum="7DAA7174A1D9E853" modified="2017-06-07" version="1">MIQLDGISKVYKIRSGYMKYHDLYALDSISTTFRNNVISGITGSSGSGKTTLANIITGYDTDYAGQILYNNSPVRTAGSVRYVFQDPYISMNPVKTVEWHVSTAASINNVEISDAIEKLEMAGMDYSIYKDRYGHSLSGGELQKLALAISIIPEPEFIVLDEAFSMMDSITLFKTLNFLKQLKKNISIIYIDHDINRVAFASDYVYILNHGKIIEENYTDNIMNTPLNDFTKELIKYSPDYHRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N466</accession>
    <name>A0A1V0N466_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142324.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N466"/>
    <dbReference type="STRING" id="74969.FAD_1005"/>
    <dbReference type="GeneID" id="31676504"/>
    <dbReference type="KEGG" id="fai:FAD_1005"/>
    <dbReference type="OrthoDB" id="27015at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43637">
        <property type="entry name" value="UPF0273 PROTEIN TM_0370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43637:SF1">
        <property type="entry name" value="UPF0273 PROTEIN TM_0370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC-like" evidence="3">
        <location>
            <begin position="249"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="469" mass="54465" checksum="947FB1919B2C58EA" modified="2017-06-07" version="1">MNVDDLFIYDLKYGKLNGQLINNEFYAIGDVYMNEDLPAILERLEDYGYVTEQGSVFDLKCKYCGGDNFMVVPFSESGNIAMDIDKSPPDPDNLKEVYICRDCRKINIPDGKWNKYKKYLIKDMVNNVADALHEFIKILDENKLTYEIPSMITCKSRSHIFSVKITVDYDYFIDIYSHADFREVLENTELFKSEFPSRKMAIFNISDKFTDTGTGSEIEYYSATSKDDLVLKLRQYVNKILTSKEYRFGIDEFDNILLYGLEENNVYGIETFSSGNTLYFLSKFLMQGALHGQNGLYITTRYSPDYILKIADSFGMNIRQLVNDKKIFIFDGNSSLEKFQHSESDIWKIRDHISKVIAEIGKYITKYNIKRLVIDSIEPLEINPGEDSIRYLFNELKNLDCVTMATKYINNINSNSIEDMYFTGIVEIGTVIDLNSIKNIIVIKKFMIRDNSRRLVEYNITDKNTLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N471</accession>
    <name>A0A1V0N471_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142421.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N471"/>
    <dbReference type="STRING" id="74969.FAD_1057"/>
    <dbReference type="GeneID" id="31676556"/>
    <dbReference type="KEGG" id="fai:FAD_1057"/>
    <dbReference type="OrthoDB" id="41733at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14342" checksum="6DEE3DFA195C827A" modified="2017-06-07" version="1">MATNKAIDILRWLGILGSAIWAGIHMTLLGLTLPYIVKAFFGFVIAIAIVSAMIYVSDKKEFYLPVFIFYILDTILLLESRISIAPVFNERLPWTASAIDSIILDVIMIIISGAIYFSTGALKSKGANQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4C2</accession>
    <name>A0A1V0N4C2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142467.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4C2"/>
    <dbReference type="STRING" id="74969.FAD_1080"/>
    <dbReference type="GeneID" id="31676578"/>
    <dbReference type="KEGG" id="fai:FAD_1080"/>
    <dbReference type="OrthoDB" id="6837at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02014">
        <property type="entry name" value="TPP_POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07039">
        <property type="entry name" value="TPP_PYR_POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047211">
        <property type="entry name" value="POXB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047212">
        <property type="entry name" value="TPP_POXB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047210">
        <property type="entry name" value="TPP_PYR_POXB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005040">
        <property type="entry name" value="PRK06457.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42981">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE [UBIQUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42981:SF2">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE [UBIQUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="186"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="370"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="549" mass="61235" checksum="B11AC36AF1834FD9" modified="2017-06-07" version="1">MSTVADVIIKTLVNFGVKRIYAIPGDSLNPIIDAIRRNKDIKYVQVRHEEGGALSASYESKYTGNLSACMGTSGPGSIHLLNGLYDAKTQHVPVIALTGQVETELLHHDYFQEVNLVKLFDDVSVFNARIITPDNAHYLIWKACREAITKKGVGHIDMPVNILMESCKEEDLSYYINPVSYNPGGLDEAVNLINNRNKPVIMIGGGSRNYRGEIDKFAEKIGAPIIYSLNGKGVFNDNDKKVMGGIGLLGTKPSIKAIEKSDLIIFLGTIFPYTQFLKKVDNIQVNTNIDDLNKIMKANYSYLCDIKYFLDNINVNKKDKKFYQEMQDEKTKWSEDMARLASNNKNPIRAELLTDKISKKIEDDAIIITDTGNVTLWSNRFLKAGNNNKFYFSSWLGTMGSGIPGSVGLAFASGKKIYGLIGDGSFAMTMMELITIKKYNLPVKLIVYDNSILGMIKLEEEVMGYPEYGVDLYNPDFSKLAESIGILGIRIDTVEALDTGLDKFFKYDGPAVLDVVTETNETPMPPKLNFKVAEKYVTSILKEKLETKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4E2</accession>
    <name>A0A1V0N4E2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142501.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4E2"/>
    <dbReference type="STRING" id="74969.FAD_1127"/>
    <dbReference type="GeneID" id="31676624"/>
    <dbReference type="KEGG" id="fai:FAD_1127"/>
    <dbReference type="OrthoDB" id="110773at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053172">
        <property type="entry name" value="Tn903_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053520">
        <property type="entry name" value="Transposase_Tn903"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033579">
        <property type="entry name" value="transpos_IS5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631:SF3">
        <property type="entry name" value="ISSOD12 TRANSPOSASE TNPA_ISSOD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="129"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="308" mass="36288" checksum="4CB9F3A578D02DA4" modified="2017-06-07" version="1">MTPQINNKINRSIKRYWIGSNRRWEKYNESLVDRVEYLTDLSFIKDYDTLLEEKNNGKIGHPYKVPDALIMYLARLRSIFNIPFRTLEGMLRSLAIIANIKSISYSEIFRRIRRIKPDLNNNINNKLDCIIDSTGYKITIRGDYLGHKWHKKRKGWLKLHVIISMKDVNVLSFTITDEHTHDSKAAKVLLNKMKSNILRIFGDRGYDSKHIYNMFGYNAIIPPRKNASTKSRGSSARAKIVRFIKKNSMEQWKENNSYGKRWIVEIYFSGLKRVMTEVIKAKKIEYIIQELALKVVNYNIMRGMTHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4G8</accession>
    <name>A0A1V0N4G8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0933</name>
        <name evidence="4" type="ORF">FAD_1156</name>
        <name evidence="5" type="ORF">FAD_1497</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143156.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4G8"/>
    <dbReference type="STRING" id="74969.FAD_0933"/>
    <dbReference type="GeneID" id="31676988"/>
    <dbReference type="KEGG" id="fai:FAD_0933"/>
    <dbReference type="KEGG" id="fai:FAD_1156"/>
    <dbReference type="KEGG" id="fai:FAD_1497"/>
    <dbReference type="OrthoDB" id="136106at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614:SF2">
        <property type="entry name" value="TRANSPOSASE IS4-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase IS4-like" evidence="2">
        <location>
            <begin position="183"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="464" mass="54280" checksum="CA7EB1F654D8B285" modified="2017-06-07" version="1">MEEWVKDVLQEEKRKRKIPLEVKRLNGNYYLYHSTTKYDKEKHGARKVSDYIGRITENGIVSNDNSRSVYEYGNSELIYSVSKDIIKLLKKYFPDTWESIYAMSVVRLISYTPMKSIKERWDKLYMSRYINAHVSPNTLTDLLIETGSDISSQYDLFNDLMHDSMKLAFDLSSIFSRSENINMAEKGHNHEHEYIPQINIAMVFDLDYYKPVFLKSLDGSVRDIKSLRKVLEEINFNGVLVMDRGFASYSLADEINNKFIMPLRRNNKIIDYNAIFKSSFMYRDRGILCTSYKYGKYYVYIFQDQLLMSEEANTFISLIADNKKSQDDYNSASKVFGKIAILSNIDDKPENIYLMYKQREEIEQSFDAMKNELENDKSYLSNDDSIRGYFFISFVSLYIYYSIFVLIRAAGLTDKLSVKDALLKYSRVYRIVHNSKEIISEVPASSERIDEQLGTNIFPKKLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4G9</accession>
    <name>A0A1V0N4G9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142533.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4G9"/>
    <dbReference type="STRING" id="74969.FAD_1147"/>
    <dbReference type="GeneID" id="84217744"/>
    <dbReference type="KEGG" id="fai:FAD_1147"/>
    <dbReference type="OrthoDB" id="24876at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02803">
        <property type="entry name" value="OYE_like_FMN_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="547" mass="61752" checksum="D9D7D6CE7BBAF13A" modified="2017-06-07" version="1">MNPFEKANIGGAEIKNRFVMAPMISNLCNPDGTTNENHIRYLEERARGGFGLIITEYAYVDDSNGKGSPNEMGIFSRSQLPKLSRLTERIHSAGSKIFVQLVHSGGKANPHYNTGKIFAPSSVDYIGSIPEEMTKDDIKKVEEKFVNAAELAYRAGFDGIELHGAHGYLLQEFISPALNKRTDEYGGSVENRIRIINEISSAIKSKLNMPLGIRLSLYEDDEDGYDADYGIDVASRLENMDYVHFSSGRFAPPGSSASFYYDNVHIGAKLKKKLDKNTMLVGSIRSMEDIEKALTVSDFVVLGRQALADPYTPVKIKMKMPYRVCIRCNQACRNLANAEVRCTINPYTGIEETIQPGRKYHGEIAIVGSGIKGLEAALYSANKGFKPIIYEESSFGGQFNEIIDKYKKRDFTPLIEYYRSMLEKYGIEIRHESSNTGIFCLPDKVYPDILDMGDVSIDTNIYRYFDDALRIAEKNKVIMSNNSLNSLERSRVTGYRRLAEKAGIEFKDMDHYDFKLYDSSQYDILEAMKSGRRVIENYILENETEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4I2</accession>
    <name>A0A1V0N4I2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1138</name>
        <name evidence="2" type="ORF">HLB00_04815</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000164">
        <property type="protein sequence ID" value="NOL60157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886242.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4I2"/>
    <dbReference type="STRING" id="74969.FAD_1138"/>
    <dbReference type="GeneID" id="16024367"/>
    <dbReference type="KEGG" id="fai:FAD_1138"/>
    <dbReference type="OrthoDB" id="379809at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="206" mass="22892" checksum="66E275155989488D" modified="2017-06-07" version="1">MRIAGLISEQAIENPVKVNYTWYEKAKGIIQWNFENTGSTTRSFILLRGITENNKVSEIYAFGDAFYPLYYKNFNVDFVTEPEPLANVSARTNNAPLAVIENSDSRLLVAFLYTLSGGSKYSVLEGGWTGVEPGGIKIVLAKYSGTKDFSIKYEKKQCTLYNEESSTDYGCPDDPFTVKSALMRVNNPIKPLFNDTISAAGDNNCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4N7</accession>
    <name>A0A1V0N4N7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase (Flavoprotein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142643.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4N7"/>
    <dbReference type="STRING" id="74969.FAD_1231"/>
    <dbReference type="GeneID" id="31676729"/>
    <dbReference type="KEGG" id="fai:FAD_1231"/>
    <dbReference type="OrthoDB" id="6062at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050407">
        <property type="entry name" value="Geranylgeranyl_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685:SF22">
        <property type="entry name" value="CONDITIONED MEDIUM FACTOR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="325" mass="36891" checksum="AE5401B1B3CB5CF6" modified="2017-06-07" version="1">MDNKNYDRIKIAGLGISGIYLYRRLKNAGFDVRAFDPKKRGYYIPCGYATNEFNISRYMSNINIDFSDYVLSRADDITFSGNKFDGRTLKSSGLCTFDKNRLEENAAAGIPMSPIRQEEGDLIIDATGISRAYIGPSAGDLQYRTLEYLTTYSDYKDFYFYFLPGGRGYFWSFPLGREFHIGVGSLSSEDFSLVRKYRKIKIATRNIRMSPLFKNMGKENIIGIGEAIGTVSPITGEGIVPSLESAEILFNCLKTGDVTGTLEEYRKLINQRFGYYNKLASVVMNIQRGNIMRLRNLVAVKDIKKTINEFGIKLEIMPFLKHFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4T1</accession>
    <name>A0A1V0N4T1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15 16">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15 16">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="19" type="ORF">FAD_1249</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15 16"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142668.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4T1"/>
    <dbReference type="STRING" id="74969.FAD_1249"/>
    <dbReference type="GeneID" id="31676747"/>
    <dbReference type="KEGG" id="fai:FAD_1249"/>
    <dbReference type="OrthoDB" id="8674at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="34"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="360"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="NCBIfam" id="TIGR00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ARD85117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="552" mass="59403" checksum="BCF87ED6C07476F5" modified="2017-06-07" version="1">MKRSDLTYSGPERAPNRAFMKAMGLNDNDLKNYMVGVAAAWNEAGPCNIHVLSLANHTKEGIRSREGTPRVFTTPVVIDGIAMGTEGMKYSLVSRELIANTVELTVNAHGYDGFAALSGCDKTSPGMMMAMARMNIPSIVMYSGTTLPGYYKGKRIAVGDLFEAVGAYMNNTMTLQDFKLMEENAVPTAGACGGLYTANTMAMMTEVLGLALPGSASPPAVDGAKQKFAYKTGEAVMQLIETGLKPRDILTQESFYNAITVLMASGGSTNAVLHLLAIAHEAKIKLDLDDFDRISRKVPEIVNMKPSGEYVMADLNNIGGVPVLMKVLMDHGLIDGDQLTVTGKTVKENLKDIKIYTTGDVISDFDKPYKPDGGISILKGNLATEGGVFKTSASKVKYHKGPAKVFNSEEETFKAIKDKKIKAGDTVVIRYEGPKGGPGMREMLSVTSELIGEGLGDSVALITDGRFSGATRGIMVGHIAPEAMDGGLIAIVKDGDMIEIDAPNRKINLLVDENEITRRMKEWKKPPLRYETGLLNQYAKLVASSSKGAVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4U7</accession>
    <name>A0A1V0N4U7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4U7"/>
    <dbReference type="STRING" id="74969.FAD_1257"/>
    <dbReference type="KEGG" id="fai:FAD_1257"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="162" mass="19027" checksum="344233F184EDABB6" modified="2017-06-07" version="1">MVSYYGVYCVTIKDRKVANYENIYQILQLKVDLIFVIDYDALKNRYLNLKLYEELAKFFELTVMNYPETESDLMDTIINGASVVVVNNNLTFKRIAKYLEFTQNIAMKYRYIDTCIYFAEKGGNMYLTDKEIMLPYTLAYSARGFPIKNSVQLQNFPPDLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4W1</accession>
    <name>A0A1V0N4W1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sulredoxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Rieske (2Fe-2S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1276</name>
        <name evidence="7" type="ORF">HLB00_03245</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000103">
        <property type="protein sequence ID" value="NOL59849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142741.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4W1"/>
    <dbReference type="STRING" id="74969.FAD_1276"/>
    <dbReference type="GeneID" id="84217871"/>
    <dbReference type="KEGG" id="fai:FAD_1276"/>
    <dbReference type="OrthoDB" id="6837at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053457">
        <property type="entry name" value="SDX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041174">
        <property type="entry name" value="SDX_Thmprot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF24">
        <property type="entry name" value="SULREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="111" mass="12405" checksum="6E6A3023BA7B6F5F" modified="2017-06-07" version="1">MTWRKILGIKALENSGNHVSINLGDGKVVFITKQNGKLYGINGICSHLKCILGNVSEDGKHVVCPCHNAKFELDTGKMVEPPFIAPQTPMEKYTLETYNLREEGNFIEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4W2</accession>
    <name>A0A1V0N4W2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142747.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4W2"/>
    <dbReference type="STRING" id="74969.FAD_1279"/>
    <dbReference type="GeneID" id="31676777"/>
    <dbReference type="KEGG" id="fai:FAD_1279"/>
    <dbReference type="OrthoDB" id="56770at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="452" mass="49447" checksum="78539E9930BDDA98" modified="2017-06-07" version="1">MKMYKKLITGFIVLSMVMLAIGASGLMSSGDAIHNKTAPATVANNELTVTSVSWFAPNSTELPSPGSNGIPLYVTFESYTDIENANVSMNLSAYKSPFTYAYINGPDKNVRTYNRIPEIQAGHSYMIMQLVNISKNASGSFYDENISYNNSTMSGNTVFTIPVGKPDVSVISYTTNPPVIYQNEKFIKLTIYTENTGTSAMKNVNFNITSMDYKVVSPGNYSIAYYPAGTLMNFTFYINAKNVTGTIPVYFHINNVVYTINTYIHGSEEKSLTVAVENKNLVSDTKKQLLTFYLNNTGNKVYRDLEIHMLSPGVLSIHVSSSNPLGALTANNVTFAQLQPGQSIKVTYIIDTSTSAAGTYPVQLLVEYHFNNTAETFNKVYTYNQKIVPTTTQQISNTLTEPLYAGMAALIIIILGAIGAAVLHTGKKNRKSKNAGSKKAKEKNNNGSGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4X9</accession>
    <name>A0A1V0N4X9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4X9"/>
    <dbReference type="STRING" id="74969.FAD_1281"/>
    <dbReference type="KEGG" id="fai:FAD_1281"/>
    <dbReference type="OrthoDB" id="70849at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="66" mass="7579" checksum="DDE5226E45822920" modified="2017-06-07" version="1">MAIHMDEYRTTKICPQCGSLRINWIAGGIAGPVYKCEECNYVGVFVLEVKLKDLEKFQKEIREGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Y3</accession>
    <name>A0A1V0N4Y3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5680 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1337</name>
        <name evidence="3" type="ORF">HLB00_03175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000101">
        <property type="protein sequence ID" value="NOL59835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142816.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Y3"/>
    <dbReference type="STRING" id="74969.FAD_1337"/>
    <dbReference type="GeneID" id="84217949"/>
    <dbReference type="KEGG" id="fai:FAD_1337"/>
    <dbReference type="OrthoDB" id="203807at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043735">
        <property type="entry name" value="DUF5680"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18931">
        <property type="entry name" value="DUF5680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5680" evidence="1">
        <location>
            <begin position="46"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="151" mass="17137" checksum="E00B705CCFA31EE7" modified="2017-06-07" version="1">MDDNKLTKFLTSAKLNGYSSGNAYYKGKIAGTMEFSFKDGKLKYADIYSGTVSFIGQETVFENNIPQWGMVYYGAILDDSYDSKEVYDFLRSALRTMPESLPLRGNDVFSNNKFTYKNASEGDIGHFMGYEEIEEADNVIYEMHYSGGYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N506</accession>
    <name>A0A1V0N506_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1328</name>
        <name evidence="2" type="ORF">HLB00_05610</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000188">
        <property type="protein sequence ID" value="NOL60309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142804.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N506"/>
    <dbReference type="GeneID" id="31676820"/>
    <dbReference type="KEGG" id="fai:FAD_1328"/>
    <dbReference type="OrthoDB" id="57125at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="130" mass="14627" checksum="4F31E4751507226B" modified="2017-06-07" version="1">MPGKIMVSGEVFLDGVKPDDAIIFIHIKGHGRARVTHIDIESMAFKKILLPRHSDYPEICWDSDKVSIPVKGHELIIISPTLGKLMKFHGNLYVRGKGKGIFFGLHREQIKTIEEYASKLGIPPKITKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N513</accession>
    <name>A0A1V0N513_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin acylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142812.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N513"/>
    <dbReference type="STRING" id="74969.FAD_1334"/>
    <dbReference type="GeneID" id="84217946"/>
    <dbReference type="KEGG" id="fai:FAD_1334"/>
    <dbReference type="OrthoDB" id="56056at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="entry name" value="Penicillin Amidohydrolase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218:SF4">
        <property type="entry name" value="ACYL-HOMOSERINE LACTONE ACYLASE QUIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PEPTIDASE S45 PENICILLIN AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="833" mass="93254" checksum="FBE407734A024D9B" modified="2017-06-07" version="1">MKVFSSKKRFIVGVIVAIVIISMISVSIGPLPPTNKLLNPSKGIYSIPPEYKTGAKYMNITYNGKTAEVITFQESDGFIGIYSNHNWSLYYEQGYLEAKYRLAQMVFIKKEAQGTLSELVGKSELSSDIFSRELMDCQIAKSEVNNLSKTSYTYMATSNFVSGINSYINNLSYGNTPLLFKLLNYKPKDFNITNIFAIQQTFLWENSAGGFEPLYFQYALQKMPENIIKALYPAYQAGIQNPIVPYQCNPGIYNETGDINNLTLYTPSVHIPVNISSIPAFSSPTSLAFPSSESFSNDWAVNGVKTDNVSALLANDPHLTTSVPSIWIGFQLVSPGMNVIGVVFPGFPGIILGHNSYIAWGATNGQTQETYFYAEETSSSHPYSYYSNGNWTKFTVINETINVKDSKPYNLQLEVADNGVVVDNDSGTKIAMDWTGLSPSYELTFFLHIDRAHTVSEFRDNLTQYFKVAIQNWAVAGSKGNIGIFPYGDYPVIESGNPRGVLNGTGRSNWVGFIPLKYEPSLYDPARGFVFSANQITVSPGYPYYTGWLYETGPRANEIYSLLNSTSGFNTSKMEKVQLSVHDYSTNIFLKPLLKSIEKYYGNTEIYNELESWNGNMDINSSAASVFHFWEHNIVNDTFLPYMEEYGITPQDGLYNISFFLGSDVTYHGPLMEDLVNWTINYPDSTYFNNPLNGNVENFSSLALHAFNQTINELNKKYGTISSKWDWGNIHKRYLSSFFSINTLNTKEIPAAGNGNTINAAYGLTSNFGPSWRLIVNLSNPAKSVGIYPGGISENPLSSYYSNNFIPWNNGVYYTLIPVNMPEQFYQGYGDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N514</accession>
    <name>A0A1V0N514_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9 10">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pfdB</name>
        <name evidence="12" type="ORF">FAD_1366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886466.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N514"/>
    <dbReference type="STRING" id="74969.FAD_1366"/>
    <dbReference type="GeneID" id="16024591"/>
    <dbReference type="KEGG" id="fai:FAD_1366"/>
    <dbReference type="OrthoDB" id="56001at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23162">
        <property type="entry name" value="Prefoldin_beta_GimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02338">
        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="NCBIfam" id="TIGR02338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="127" mass="15028" checksum="79FF9AD82A0A075C" modified="2017-06-07" version="1">MVEPNLNAYLQNQIKQAQDMQAQIEQVANQRYQIDMKVKELDKTLKELNTVGKDAPIYKNVGPIIYKIDDREKLVSDLEEQKELSQMRLKTLENQQKTLEEKYKELEQAIQKRYEESTRNQNNQGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N520</accession>
    <name>A0A1V0N520_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_1332</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142808.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N520"/>
    <dbReference type="STRING" id="74969.FAD_1332"/>
    <dbReference type="GeneID" id="31676824"/>
    <dbReference type="KEGG" id="fai:FAD_1332"/>
    <dbReference type="OrthoDB" id="52603at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002049">
        <property type="entry name" value="PRK00881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="500" mass="56245" checksum="81E3F48BA418DA92" modified="2017-06-07" version="1">MRILISVYDKTGLVNFLSSIKDHIDEIYGTEGTVKYLKDNNIAANNSSNLTGFDDLLGGRVKTLHPAIFSGILSKRDSESNMQLEKYHYKDFDMVICNLYPFVEASKTDDLEKMIENIDIGGLSLIRAAAKNYKNVAVLSHPDDYSMVKDVLQKNGKIDMKTKEILGLRAFSRSADYDIQIYNRLYRKLNDKQPEELFIHGYDRTDLRYGENPDQEAYMFKVNEKYGIPNSIQLNGKELSYNNILDANAALETVQDFQDITSVIVKHRTPSGVSSAGTLKEAFINSYNADPESAYGFVVALNRKLDMDTAKEMQKKFIEVLIAPEYDTDALNLLKKKKNMRILKCSMDHDPEKAIYSVSGGVLVQSRLDYRYDNLELKSTAEAGKEKLADLEFAWKVVAHAKSNAMVLAKNRTTVGIGAGQTSRIESLKIAIERGNSNVKGSVLASDAFIPFDDSVIECYKNGIDAIIQPGGSIRDDDVIKRCNEYKIPLYFTGKRVFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N527</accession>
    <name>A0A1V0N527_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N527"/>
    <dbReference type="KEGG" id="fai:FAD_1389"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="154" mass="17731" checksum="23EC095E6FA94FB1" modified="2017-06-07" version="1">MNNNTKNVKKISNYIIISIVVLTFLFIIMFYRLAYLGSIGNIISAKYNFYTGIFPVAIIGFVGIDIIFYLEYLRDKLSHNSVRHNLAMWVYLLFIFLFFSLILPLLLPSTGNRPQIISHSMLMINLITIGIPGVFSLSIPIYLLVTSHRFPRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N565</accession>
    <name>A0A1V0N565_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N565"/>
    <dbReference type="KEGG" id="fai:FAD_1378"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="Zn_Ribbon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="210" mass="24402" checksum="23CBD8DEE9696318" modified="2017-06-07" version="1">MYVMPIYESDEHEFLNAKAKKIENNVYIKGLLFLTDKRIIFEKNGHRSMFRASPAVMDLNLFLYNVENANYAAPAFALFTKQVLTIEYYDDSRKLARADFAIKKSKMWVDQITRLATICKKDESTRKEREALEIKKHEIDMAKARAPRANIGMAVFGNDKKNPYQNLRENMAENNDENLPDTAHRCPHCGYPVTEDMIYCPNCGYKLKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N594</accession>
    <name>A0A1V0N594_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886536.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N594"/>
    <dbReference type="STRING" id="74969.FAD_1429"/>
    <dbReference type="GeneID" id="24787172"/>
    <dbReference type="GeneID" id="31676921"/>
    <dbReference type="KEGG" id="fai:FAD_1429"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11892" checksum="0DA12F94A7E3085D" modified="2017-06-07" version="1">MAQLDRNGAVRLFRLRLVTFSLSLIFILSFFIFTYFTLNTGYAARHLHIFITGFTVLVVAAIGTGIETVILTRAAISKFTGKNMNDLKPDEVSQAIQRLRILRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N597</accession>
    <name>A0A1V0N597_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanyltransferase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142883.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N597"/>
    <dbReference type="STRING" id="74969.FAD_1410"/>
    <dbReference type="GeneID" id="31676902"/>
    <dbReference type="KEGG" id="fai:FAD_1410"/>
    <dbReference type="OrthoDB" id="15372at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04181">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="308" mass="35786" checksum="CE2D325C48564B1F" modified="2017-06-07" version="1">MIGAILAGGYGKRLKPITDHIPKALVEIKDNYTIMDRQLFDFKNIGITDVYILSGYLSEVIEERYKNYKDMNIHYLREDKPMGTLFSLSNLMKNINEDAIVRNGDTVTDINFRSFVEFSKSRAYDVIMYVTKMQSPYGIVEFSGDKVDNFREKPELNHYINAGLYYIKKSAFETFFRKYMEKDIEKSVFPYLVNNNRMGVYCEDALWFGIDSEKDLGTIKELYKGREDTSYGYLKTLYFDKSKSIVEYYIRSGENVEIQAGKILKIDSGTGYIENDTDQKYSKGQVIRTGDTTLLYAYENTIMEEISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5A4</accession>
    <name>A0A1V0N5A4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142918.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5A4"/>
    <dbReference type="STRING" id="74969.FAD_1455"/>
    <dbReference type="GeneID" id="84218047"/>
    <dbReference type="KEGG" id="fai:FAD_1455"/>
    <dbReference type="OrthoDB" id="98602at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707:SF1">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core" evidence="2">
        <location>
            <begin position="64"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core" evidence="2">
        <location>
            <begin position="177"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="250" mass="28571" checksum="0A66BBE6EB44454B" modified="2017-06-07" version="1">MEDQKLSDIAYSIRKSCHDSGYSEIFPPAYVKSDRIGGFRFIFRNDVYVLEPDITLRLMNNRFPGNSRVYYISRQADEFLGESLKAGLEIIGAVPGEANIEILKMAIKILDDLGIRDYNIDISITDVFDPYRKKKDGDIILNAVKNRNYPQLQNMDIDGMDKLFQIMDTRTRNSGIPELDSILEEINDPRVIIDLGTVRQPEYYRGLIFEIYGRHEFLGGGGNYVIKKMNGCGFSLDLQALSKLYGDVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5D4</accession>
    <name>A0A1V0N5D4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="10">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="10">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">ImGP synthase subunit HisH</fullName>
            <shortName evidence="10">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisH</name>
        <name evidence="13" type="ORF">FAD_1451</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="10"/>
    <dbReference type="EC" id="3.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142914.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5D4"/>
    <dbReference type="STRING" id="74969.FAD_1451"/>
    <dbReference type="GeneID" id="84218043"/>
    <dbReference type="KEGG" id="fai:FAD_1451"/>
    <dbReference type="OrthoDB" id="33401at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701:SF1">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="12">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10 11">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD85309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="189" mass="20983" checksum="8A29FF833F531A28" modified="2017-06-07" version="1">MIAIIDINTGNLSNINRIVRGKVTSDPYEIEKSEKIIFPGVGSFQYVSQIIKPIKDLLVERIKSGIPYLGICLGLEILFENSEEGPGNGLGVFNGTVKKFNGVKTPHMGWNTVNVKSPSKIMEGIGNDSFFYFMHSYYVPENQYTVMETEYGNKFASGIEMGNIYGVQFHPEKSGNDGIRVLKNFGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5E9</accession>
    <name>A0A1V0N5E9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1518</name>
        <name evidence="2" type="ORF">HLB00_09470</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000417">
        <property type="protein sequence ID" value="NOL61047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886657.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5E9"/>
    <dbReference type="STRING" id="74969.FAD_1518"/>
    <dbReference type="GeneID" id="16024784"/>
    <dbReference type="KEGG" id="fai:FAD_1518"/>
    <dbReference type="OrthoDB" id="55515at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL61047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="83" mass="9372" checksum="4884C1FA833DDDF2" modified="2017-06-07" version="1">MDDNNNAVMGFKLDEEPKWIRVTLEDGTVLEIKTEIMSIMKVGNDPNTGLPQYSINAAPMIRMMRVPKESVAKKADTDKGLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5F6</accession>
    <name>A0A1V0N5F6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795591.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5F6"/>
    <dbReference type="STRING" id="74969.FAD_1491"/>
    <dbReference type="GeneID" id="60420016"/>
    <dbReference type="KEGG" id="fai:FAD_1491"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="58" mass="6659" checksum="2B278F19B69DAA90" modified="2017-06-07" version="1">MKSKIVCPKCNEEFDAPRWDKKRFGFGAVPPGVGFIKCPYCKYKAHRSEFSVAEDTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5G8</accession>
    <name>A0A1V0N5G8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1505</name>
        <name evidence="3" type="ORF">HLB00_07760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000289">
        <property type="protein sequence ID" value="NOL60724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142935.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5G8"/>
    <dbReference type="STRING" id="74969.FAD_1505"/>
    <dbReference type="GeneID" id="84218098"/>
    <dbReference type="KEGG" id="fai:FAD_1505"/>
    <dbReference type="OrthoDB" id="11098at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04179">
        <property type="entry name" value="DPM_DPG-synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050256">
        <property type="entry name" value="Glycosyltransferase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48090:SF7">
        <property type="entry name" value="RFBJ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48090">
        <property type="entry name" value="UNDECAPRENYL-PHOSPHATE 4-DEOXY-4-FORMAMIDO-L-ARABINOSE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="220" mass="25065" checksum="4E0E5DCDE754D4C7" modified="2017-06-07" version="1">MNVTAIIPTINEEGTIGLVIDGLLNSVEGIEIIVVDTNSTDRTKEIATGRGATVINESRSGYGMAYKTGLQHAKGDIIVCMDGDNTYPTDIVRPLLDIIRMDEVNFISCDRMTLRTQHNYTSLHYIGNSVLNFTMRLLFKINLNDSQSGMWIFYRDFYDKMKNLSNGMSFSEDIKIDAVRLGKLIEIPIKYGIRISKPKLNTWRDGFRNLFHLFVKRIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5N8</accession>
    <name>A0A1V0N5N8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Thiolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1550</name>
        <name evidence="5" type="ORF">HLB00_00935</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841461.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5N8"/>
    <dbReference type="STRING" id="74969.FAD_1550"/>
    <dbReference type="GeneID" id="16024819"/>
    <dbReference type="GeneID" id="31677041"/>
    <dbReference type="KEGG" id="fai:FAD_1550"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="3">
        <location>
            <begin position="273"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="410" mass="44143" checksum="DE75C856813DCA8E" modified="2017-06-07" version="1">MIAGGMTKFVKSNFREDFRLNVKKSFDYALKDAGMSVKDIDGSVSAYFSDHLQGQLIAGAMSNDFIGLAGKPSKRIEGGGATGGLAFQTAYEEIASGNMDTCLAYGFENMSHVGTWRGNDIIALGSDANFDYPLGGFYTAYYALMATRHMYEFGTTEEQMAMVSVKNHRNAINNPFAQAPMNITVDDVLKSPVVSTPLRMLDICLMSDGAACAILASEEVAKSFSGKPVLISAIGSSSDTMRLADRPFGDVPLLPNENSAMYRGLKYPGVHSFRAGRLAAKMAYDRIGIKNPEKEIDFAELYDAYTSAEIQAYEDMGFCPYGKGGKFIEEGNPELDGSLPVNMEGGLQASGHAIGATGIMQAVYAFWQLQGSMQKHMGNGKLQVKPPSRGLIHSHAGTGAYEAVTIMEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5V1</accession>
    <name>A0A1V0N5V1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143029.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5V1"/>
    <dbReference type="GeneID" id="31677180"/>
    <dbReference type="KEGG" id="fai:FAD_1688"/>
    <dbReference type="OrthoDB" id="57340at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14720" checksum="2A7A59F9C5ECCC9F" modified="2017-06-07" version="1">MRYENIYKSILFYIASLLLLYLSIFLSNNLKYNGHFISALPIVLPLIFSIASIGIAVLLIMEKDSPWFFRTGIMSLVGGITLFSFGILAFYLRVKSLVWAGSFVLGILFILAAMVRLLIQGGLSAYRKSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5W3</accession>
    <name>A0A1V0N5W3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xanthine-guanine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143006.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5W3"/>
    <dbReference type="STRING" id="74969.FAD_1663"/>
    <dbReference type="GeneID" id="31677152"/>
    <dbReference type="KEGG" id="fai:FAD_1663"/>
    <dbReference type="OrthoDB" id="4952at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="215" mass="24920" checksum="FC4B7187BCCA9EF7" modified="2017-06-07" version="1">MEFKATYVSWNEIEEWTKGIMKMVIEDNYNPDIIIGIARGGLVPSRMVADYLFKKDLLSIKTEHWGLTATMDGKAVLKEKLNYDITGKKVLIVDDITDTGESMKLSYNYIKSLNPATVKTTSMLYVNGSNYTPDYYGKGLSKEQWAWFIFPWNVYEDTYNLSKKFMEDPIDVEKLEEKLVENYNLNVEDVNLSEVLENIASLKMLKKRENKFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Y3</accession>
    <name>A0A1V0N5Y3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143053.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Y3"/>
    <dbReference type="STRING" id="74969.FAD_1720"/>
    <dbReference type="GeneID" id="31677211"/>
    <dbReference type="KEGG" id="fai:FAD_1720"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="453" mass="49450" checksum="4B4257BF1F1CB3B2" modified="2017-06-07" version="1">MVENFDKVKDIIARTNRIPVWSLPTAFLGIIGLGYFFTFYDISDIGLAMPAIDQQFNLHGSIILFIALSVGLIGYAIGSYMIGSLADVFGRYRSMILTMALTAIGSLGDALSFNVPELTIFRFITGIGLGADLNLVSIYITEFAPAAVRGKITVFTFLIGIFGQAVTPFIGYFLVPAFTTGWRWLFGIGAIIAFIAVFLRTELPESPRWLATKGHNLEKAEKVLEMMEATAKKKIGELPEPHPENIVVEEPKFPTLYLFKKPYSSRMALLISVWFLWYIGNYAFLGDAASLLESIGFSVAAAILYIAIGAIIGYPVGALIMLYTSDKYERKHVIFAATVVWFLGMLSMATRITDLLYFGSFLAAMGLGMYLQVAYTFTAENYPTRARSSGFGITDGIGHGGGALGAILLPILVATYSWAFGFTFIGITGLVAGLLILIGGTKVSRRNLEDISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Z5</accession>
    <name>A0A1V0N5Z5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143023.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Z5"/>
    <dbReference type="STRING" id="74969.FAD_1681"/>
    <dbReference type="GeneID" id="31677173"/>
    <dbReference type="KEGG" id="fai:FAD_1681"/>
    <dbReference type="OrthoDB" id="56351at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="193" mass="21665" checksum="9AB5F1BA5EE6001E" modified="2017-06-07" version="1">MAEIDFGTYHHSSLEGSIKVRALVEENMNQVLGNLYPATQKINILDAGCGLGFMVSIAAKHFPYASITGIDIFNHDSLSGSSMEKALQNMKELGIDNRVLLINHNLLTPFTIETKFDLAMSNLVFHNLGKNRFKAYDNVIECLNSGGYFILIDLLPEQYIDMDYFGNSFSTVMEIPITGNGKWDLQMKIFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N635</accession>
    <name>A0A1V0N635_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydropteroate synthase</fullName>
            <ecNumber evidence="4">2.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">folP</name>
        <name evidence="10" type="ORF">FAD_1754</name>
        <name evidence="11" type="ORF">HLB00_08550</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000319">
        <property type="protein sequence ID" value="NOL60872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886896.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N635"/>
    <dbReference type="STRING" id="74969.FAD_1754"/>
    <dbReference type="GeneID" id="16025029"/>
    <dbReference type="GeneID" id="31677245"/>
    <dbReference type="KEGG" id="fai:FAD_1754"/>
    <dbReference type="OrthoDB" id="371861at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="9">
        <location>
            <begin position="74"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL60872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="333" mass="37812" checksum="9B3C5BD47CAAB881" modified="2017-06-07" version="1">MELIFPDSINKNYLNIYEESENGKIVIEGKKYTFSSVKFEKSILKEFYIKNHIFEGYEDEISAKAENKITNKKSLIMGILNATPDSFFEGSRISNKEIVDSMLDAKPDIIDIGGESTRPGSKMVDPETEFNRIKDVLEYIKSCSNIPVSVDSRHLYTISRAMEYGIEYINDISGFSDPGMIDIAAGSNVKCIVMHMRGNPENMGEYTDYDNLYFQLNRYFYNRADEMVKKGINPENIILDPGIGFAKDFNGNMDILSSPWSFFIGFDTLFGTSRKGFIGKITGSTVKERLGGTIASSIYLNSNGVDILRVHDVRENRDAINMYNYIKGYIKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N644</accession>
    <name>A0A1V0N644_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH DNA binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1742</name>
        <name evidence="3" type="ORF">HLB00_03900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000127">
        <property type="protein sequence ID" value="NOL59976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886884.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N644"/>
    <dbReference type="STRING" id="74969.FAD_1742"/>
    <dbReference type="GeneID" id="25398799"/>
    <dbReference type="KEGG" id="fai:FAD_1742"/>
    <dbReference type="OrthoDB" id="56014at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236:SF1">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH bat-type" evidence="1">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="210" mass="24030" checksum="9AF1906CA79DE63A" modified="2017-06-07" version="1">MIELDIEFREPVEWIKDIVKTHSASIKIRDIRMGRNGAMDLLEIFLPEGKMENFSHEMESRTKTAGNNFAIVDTSHATAIVDAHECSICSTILNWDLFLTAAYSNDSGNIRMNLLVPDEATINGFTDRLESDGIKFEILRKRALSKKNDITARQEYVVRTAFELGFFEYPKKINLEGLSTRLNVSYVTLAEILRRAEKNIISSYFKGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N671</accession>
    <name>A0A1V0N671_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1746</name>
        <name evidence="3" type="ORF">HLB00_03920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000127">
        <property type="protein sequence ID" value="NOL59980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143069.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N671"/>
    <dbReference type="GeneID" id="31677237"/>
    <dbReference type="KEGG" id="fai:FAD_1746"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="211" mass="24589" checksum="0B8456ECF4CE2E99" modified="2017-06-07" version="1">MIENIDVSEVKSDTEFKEAIEIYEEAFPEGEKRPVEDIKRNIEENNEKMFIARHNGDPVLFSMIWPVENTDFLFLDYIAVGKNYRGQGVGSIFLQKIFDISENVNYNHMIFEVENPEEGDNKKQRSERIKFYRRAGAKTMTGFKYFLPPRNGSKSQEMKLMMISRKNIGKVNGKRIQSTLSQIYTHIYNRSSNDKTLNGILDDIPENITLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N693</accession>
    <name>A0A1V0N693_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N693"/>
    <dbReference type="STRING" id="74969.FAD_1798"/>
    <dbReference type="KEGG" id="fai:FAD_1798"/>
    <dbReference type="OrthoDB" id="39947at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052519">
        <property type="entry name" value="Euk-type_GlcNAc_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190:SF3">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="330" mass="35832" checksum="169E03A1578F9DBA" modified="2017-06-07" version="1">MLFAHGRMILSVDGGGTKTAAIIVDEKNYRLAGFGVAGPSNVRSVTASTSRKNILKAIKNAEKMAGSVSITGSIYGIAGYGDSIAYTEEIKSIVKSIEAISDGKAVITNDGEAAVYLVTMGDDGIVTALGTGSVGAYIKDGKVNRIGGWSYLTDDVASGYWIARNGIEMAEKSYDGIIGKTSLIEKLQEHFKLPLRDLVADLEAHFNKRVMASLAMDVDTEAEKGDKISENVLYMAFNEIKLMIDGMKKNFEKPVAVGSIGGVMQSRTIRELLHREYNGIKIFYGYHVAIGNAMRLLGSRSSEVRDSFVSQMEEKIDLLSQSERDLLFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6A2</accession>
    <name>A0A1V0N6A2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="3 11 12">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrB</name>
        <name evidence="15" type="ORF">FAD_1808</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3 11 12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886957.1">
        <property type="nucleotide sequence ID" value="NZ_JABGBP010000045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6A2"/>
    <dbReference type="STRING" id="74969.FAD_1808"/>
    <dbReference type="KEGG" id="fai:FAD_1808"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002288">
        <property type="entry name" value="PRK01212.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="13">
        <location>
            <begin position="70"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="14">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="NCBIfam" id="TIGR00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="309" mass="33792" checksum="D1E0C4C52ED1BC7F" modified="2017-06-07" version="1">MNESYYMEVTKKSYSSSANLGPGYDILSLGHKAFFDSVTVKHNNSNGVKIISNSTPEEPDKNTAGLSILKIMEDKGIKTGLDITIKKGVPIGLGLGSSGASSSAAVRSVNELLDLGMGKDEMVYYSMYGEIAACGSAHPDNVSSGIYGGLTLISSTSPVKVKKIDINYNFNLVLVIPDISMKNKTRYARSIVPQSIKMEEHIVHTSRISTMLYGFMKGDRDAIREGMNDDIVERSREAMFPFYRDIKEKVINRNAVSACISGAGPTMLIFADDKTRKDEMLGDIKNVMGSYNTDYSIRETGILEGLDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6A7</accession>
    <name>A0A1V0N6A7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenite-dependent repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsR</name>
        <name evidence="5" type="ORF">FAD_1795</name>
        <name evidence="6" type="ORF">HLB00_07570</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000280">
        <property type="protein sequence ID" value="NOL60686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_171481850.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6A7"/>
    <dbReference type="STRING" id="74969.FAD_1795"/>
    <dbReference type="GeneID" id="84218418"/>
    <dbReference type="KEGG" id="fai:FAD_1795"/>
    <dbReference type="OrthoDB" id="57427at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051011">
        <property type="entry name" value="Metal_resp_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033788">
        <property type="entry name" value="HTH_metalloreg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43132">
        <property type="entry name" value="ARSENICAL RESISTANCE OPERON REPRESSOR ARSR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43132:SF2">
        <property type="entry name" value="ARSENICAL RESISTANCE OPERON REPRESSOR ARSR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="105" mass="12003" checksum="3078F44B113982B7" modified="2017-06-07" version="1">MEKIRDVNIYKMLSDEIRLHIMKLLSEKDMPVSDIVNALNIEQPLISHKLKELRENGMTISRKSGKNIIYSISDTLLEDVLRVTENAGNKLDLACNCVECDNNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6C6</accession>
    <name>A0A1V0N6C6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148285728.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6C6"/>
    <dbReference type="STRING" id="74969.FAD_1846"/>
    <dbReference type="GeneID" id="16025127"/>
    <dbReference type="KEGG" id="fai:FAD_1846"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36719" checksum="302C78EF7154C9A3" modified="2017-06-07" version="1">MSRNIIELVKKYSVFLGGAIFAIIMPFILYIRSYLILVVMIAILAFGGSIIDNWNNTYRRGNNITNVYTGIALAGIFATIYFIHLNSIYIIFILSVLLGIFSIIYILFTHQNINYKKTVLTKKLKRYIVSIGDIKRVRNGLELLYTIFINSLLYMAIALILITIPLLAVKAGDINLIYRFVVISAASFFTVFLGSMVKSKTFQGISFVSIFPLLIVIGFLISIKNTPLDLNISILFIPAVAFLVPGYRTYITRKFPGSEKYYVNKFTNFFSGIFLITVPFIILTFIGFPMYAIIVELLASLIALIMCLKFINYPEIIPPAKYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6C9</accession>
    <name>A0A1V0N6C9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfide-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143118.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6C9"/>
    <dbReference type="STRING" id="74969.FAD_1840"/>
    <dbReference type="GeneID" id="31677330"/>
    <dbReference type="KEGG" id="fai:FAD_1840"/>
    <dbReference type="OrthoDB" id="38899at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052541">
        <property type="entry name" value="SQRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43755:SF1">
        <property type="entry name" value="FAD-DEPENDENT PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="411" mass="44947" checksum="FF7E3EE922FB74CF" modified="2017-06-07" version="1">MTKLLVLGGRFAGLTAAYTAKRLLGDKVDVTLINNTPYAAFRPGMPHVSIGVFKAEDLEVDLATALPAKGIRFVLGTVNAIDAKKNKVEYSAPDGKKENITYDYLVVAFGAKLGVEHLNGWDDYGSSVCEPDFATALHEKLEKFEGGNIAIGSGVFYQGTLKPRGKYPENWASVADSACEGPIFEMSLMIPAYLKKRGIMDKTHITIFSPGEEILTDIAKESRGVVKSLFAQAGFDTVWNFKLKELKKGEIVSEDGKTIKADIAIVLPPYEANDAVKNSTPDLFDDGGFVVTDEHMRSVKYPNVYSCGDSNQITVPKLGFLAVMTSRIAMQDLANRLGVPTKVDTYTPEVVCIADNPLEGFAIAVNDTTFYGGDEKIAQPSATNHIKKELFTKYFMWTNGDMALDKYLASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6D7</accession>
    <name>A0A1V0N6D7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">A-type ATP synthase subunit K</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ntpK</name>
        <name evidence="8" type="ORF">FAD_1825</name>
        <name evidence="9" type="ORF">HLB00_01755</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000045">
        <property type="protein sequence ID" value="NOL59560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886975.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6D7"/>
    <dbReference type="STRING" id="74969.FAD_1825"/>
    <dbReference type="GeneID" id="16025105"/>
    <dbReference type="KEGG" id="fai:FAD_1825"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18181">
        <property type="entry name" value="ATP-synt_Vo_Ao_c_TtATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="7">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="75" mass="7734" checksum="ACE379561156414C" modified="2017-06-07" version="1">MITTPDAILALAASIAIAGGLIGTGMAQQGIGAAGMGIIAEKPEKFGQVLFFFVIPETLWIIGFVLGIILLLHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6F3</accession>
    <name>A0A1V0N6F3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143110.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6F3"/>
    <dbReference type="STRING" id="74969.FAD_1826"/>
    <dbReference type="GeneID" id="31677316"/>
    <dbReference type="KEGG" id="fai:FAD_1826"/>
    <dbReference type="OrthoDB" id="86287at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="494" mass="54579" checksum="60AC19AA403D52FE" modified="2017-06-07" version="1">MNGFLYDIKRTITGKFTIILIVLLVLVTAASAYGAGVSSDYAHPGNTAIVMPYINQTGNSVNITDYVINGYGDPVSGLHITSSLYYNSNNSLIKYFSGTTNSTGYVHFIIKNLSTNLTYRYNEYYLDGIALVGSNNTMNYYNGQNILINDASTFAAPYYSINFNDSKYPLYAVNLKDKSDPALVSTMIYNPDYKFTDSPDVYYNTSSTLLNTNHFNKTNTVYIGKVNSNRFIVTPPLKTADAGKSVNIYIVNSTGAVIVPFLNYEYTYIKPGSILQDELAIFFGVLLIPIMGIFSAYFYYSKDKTSGVLESIIVRPITKGKLMMSRFAGNSVSFLAGLLIALGLADFILYHYTGVFISSGTFLTILLGYLVEIIGFAGIIYLVSQFEKTQGQVLGTGLGMLFIMGFMWSTIVSPAILYLLRVKSTGIAYFKDLLIVNSFSPSYFPDLISDYHLGSYSTYKASAVGINIYSIIAVGLIWILVPSLLALYFARKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1A6</accession>
    <name>A0A1V0N1A6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141232.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1A6"/>
    <dbReference type="STRING" id="74969.FAD_0006"/>
    <dbReference type="GeneID" id="31675520"/>
    <dbReference type="KEGG" id="fai:FAD_0006"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD83942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="470" mass="51310" checksum="CFA66D870BC588CD" modified="2017-06-07" version="1">MVENDAYSVLDNAKVGKFQRRLAVTAALGPFTDAFNEFGASISLIAVGILFHLPPVLVAAATAAYWVGVAAGAILGGIASDAIGRKQIFLYDTIGMAVFAVISAIATGYISYFLARLALGIFIGMDYAAAVPLLSEYSPSKKRGGLLSTEKLFFMFGTIATVVIGMAFTYYVGVLLAWRYDFLIAAIPAIILFGLRFDMPASLRWAKASGRKDLIPKILKKLHKEGIDIDPETVKVDKPQSIKENIHEFFNSKNKKTVAYIFWIGAAYALTVNLVSVYASTVLENLGATSFFAEEGTLIIDIVGTFGVILTLIVVDRIGRRLMGLFGFVLGAIPLTVLIVADVYHAMTIPLVISMFGLFFFINVGLVGTLQYLPAAEVSTTKSRGLAVGWEKLFEFGLALPALTLYAYIGLFYSFIYDAIMVIIGGIVLYFLSFETKNRSLERNAMEAEKKHTKSREGKSKTVQETKRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1G6</accession>
    <name>A0A1V0N1G6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydantoinase/oxoprolinase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">N-methylhydantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0028</name>
        <name evidence="5" type="ORF">HLB00_07555</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000279">
        <property type="protein sequence ID" value="NOL60683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141249.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1G6"/>
    <dbReference type="STRING" id="74969.FAD_0028"/>
    <dbReference type="GeneID" id="84218518"/>
    <dbReference type="KEGG" id="fai:FAD_0028"/>
    <dbReference type="OrthoDB" id="8261at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF23">
        <property type="entry name" value="HYPOTHETICAL 5-OXOPROLINASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="194"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="3">
        <location>
            <begin position="507"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD83963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="651" mass="71908" checksum="FC50260C35E71AC8" modified="2017-06-07" version="1">MVTVSIDIGGTFTDIIVIDEEIHYYKVPTTPANPEQAVMDGLSKYLNKNIDEFVHATTIATNSLLGQYGLELPKTALLTTKGFKDVIEIGRQNRPELYNLDFHRPRSLIPSKLRYELDERTDVNGHIIKKAETSDLESIKTSMAKNNVKSLAICFLHSYLRPENEMNIKNYLSKYFDNISISYDVSPEPREYERTSTTVVNAVLMPVVSGYLKRLKSVLDKFGSPEINMMSNAGGLVSVDEVIKKPVNIIESGPAAGVIAASEFASILGIDHVISFDMGGTTSKAGTVINYNVDITAEYEVGGSSHHGRIVKGSGYPVRFPFIDLSEVSSGGGTVIWKDKTGALNIGPMSAGSEPGPVAYNRGGKEPTLTDSNLVMGIINDKMSGSDKILRKDLALKALQKLGDPYEVAESAIKLANLEMARAIRLVTVERGLDPTEFTLFGFGGAGPQVTMPVADELGIKNVIIPPEPGVFSALGLMLANIKYEARMSYPEDLKAGFNELEQRLMYQVKNPEFIKYADCRYVGQGSELTIPVEIVDRDEIIKSFTDTHNRTFGFTLDRPVEILTIRVFAIKKRVKPDIHSVTNKELAPQKRNVYINGKWENVEVYQRNALPVKKEIKGPSVIEEDGSSTFVPPGWTIFRGENDELRAVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1H1</accession>
    <name>A0A1V0N1H1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Holliday junction resolvase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1H1"/>
    <dbReference type="STRING" id="74969.FAD_0069"/>
    <dbReference type="KEGG" id="fai:FAD_0069"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01870">
        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18491" checksum="5B4970654DDE9BC1" modified="2017-06-07" version="1">MNILIGTKNTLDRITKNLDPVSKDVVYTMMDKPFYVARAAGSFGADLVALRDDYSLVIEVKSSSRSQLTFSEASGTKQDQALKLHNRCILSGLFITYAYRLKNYKGDFWRFFSIESDYQYRGKMRGLYELLPKQEITRTGNYILRWEGGLPLTTLVNYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1J6</accession>
    <name>A0A1V0N1J6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="17">4.2.1.136</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ADP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">nnrD</name>
        <name evidence="21" type="ORF">FAD_0060</name>
        <name evidence="22" type="ORF">HLB00_07405</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Berkeley</strain>
            <strain evidence="23">Y</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 24">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 18">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 18">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17 18">
            <text>(6S)-NADHX + ADP = AMP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17 18">
            <text>(6S)-NADPHX + ADP = AMP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="18">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="17"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141274.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1J6"/>
    <dbReference type="STRING" id="74969.FAD_0060"/>
    <dbReference type="GeneID" id="84218550"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
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        <property type="entry name" value="CARKD"/>
    </dbReference>
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        <property type="entry name" value="Nnr"/>
    </dbReference>
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        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="21" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 17 18" id="KW-0520">NAD</keyword>
    <keyword evidence="8 17 18" id="KW-0521">NADP</keyword>
    <keyword evidence="6 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="20">
        <location>
            <begin position="6"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF C-terminal" evidence="19">
        <location>
            <begin position="198"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ARD83993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="NOL60653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="457" mass="49523" checksum="57DF64E875687550" modified="2017-06-07" version="1">MDYLDEKSMDINYASTYGNTYKLMKQAGKSISDFVERTIQPGKSIAIICGTGNNAGDGICCGEYLLEKYNVSVLLIKDVKGLKTQETRRAINDYNGAYYPLSSLDEVISRSDIIIDAIFGVGINGDPRKPYSEVIQNINNSGKTIISVDVPSGFPTNIQVKPDYTVTFTDIKSGMNSENSGKIIVSDIGIPEQIKSTVGPGDMVYMPISPSESHKGMNGIVGILAGWEFPGAAVMSSLSAYNVGPDLVKVFTNEVNRPIIMSYNPGIMFYPVNGKNFPDITGLNSMLIGPGMGRSKEAEDLIKYAIKNYNGQLILDADALKLITPPEVKGRNAIITPHSMEFKAFTGLEPTEENAVETAKKYGLIILLKGSKDIITDGVNIRYSYGGNSRMTMGGTGDVLAGIVAGIASRKVSPLRSASLGSFINKKCGDIAFEKFGSYYGIMDMIDNIKIIMHNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1J8</accession>
    <name>A0A1V0N1J8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ArnR1-like winged helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0031</name>
        <name evidence="3" type="ORF">HLB00_09240</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000392">
        <property type="protein sequence ID" value="NOL61003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887042.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1J8"/>
    <dbReference type="STRING" id="74969.FAD_0031"/>
    <dbReference type="GeneID" id="16025177"/>
    <dbReference type="GeneID" id="31675544"/>
    <dbReference type="KEGG" id="fai:FAD_0031"/>
    <dbReference type="OrthoDB" id="57572at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="97"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL61003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="175" mass="20633" checksum="62B2C3CD972924C1" modified="2017-06-07" version="1">MSVFVFDGDIKLVLINLSGNTNNKLKILSEVNNFYKNNTVKKIALYSGIIDQKIKYYCNTYSISLMKTIKLLNGDLEISIKVHKNWLMENSVDKNRRRNKDEIILNILETIRETDLNITNIVYRCNLNYKYCIDLIDSMIEKKIIEATEQDKTIRYKITSYGIEYMHKLESIRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1K9</accession>
    <name>A0A1V0N1K9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component Rrp4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rrp4</name>
        <name evidence="8" type="ORF">FAD_0039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1K9"/>
    <dbReference type="STRING" id="74969.FAD_0039"/>
    <dbReference type="KEGG" id="fai:FAD_0039"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22524">
        <property type="entry name" value="KH-I_Rrp4_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00623">
        <property type="entry name" value="Exosome_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023474">
        <property type="entry name" value="Rrp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003181">
        <property type="entry name" value="PRK04163.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="113"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD83974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="199" mass="22877" checksum="F07D442D295BFF84" modified="2017-06-07" version="1">MYEYNSEFFSEYFGVIQESEKFIDVAPFNSPYLPRANDKIIGKIMDIGPTMWTVDINSPYYSLLHMNDTPWHVSSGDLERYLNVGDYIYARISVSNEIKESWISLRDNGMRKLESGRIISVKPPKVPRVIGRGGNMINIIKNYTDTKIIVGQNGFIWLDGNVENVKKAIDAIRLVEKEAHTIGLTDRMEEYLKNMKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1S5</accession>
    <name>A0A1V0N1S5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpl5</name>
        <name evidence="11" type="ORF">FAD_0172</name>
        <name evidence="12" type="ORF">HLB00_02280</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000069">
        <property type="protein sequence ID" value="NOL59661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887177.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1S5"/>
    <dbReference type="STRING" id="74969.FAD_0172"/>
    <dbReference type="GeneID" id="16025321"/>
    <dbReference type="KEGG" id="fai:FAD_0172"/>
    <dbReference type="OrthoDB" id="372044at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_A">
        <property type="entry name" value="Ribosomal_uL5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022804">
        <property type="entry name" value="Ribosomal_uL5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="10">
        <location>
            <begin position="64"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL59661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="175" mass="19783" checksum="6378FA97614FB064" modified="2017-06-07" version="1">MMSKTDNPMRKIAIDKVVINIGVGAAGERLTKATKVIELLTGHKPVITSAKKTIRDFNIRKGLNIGAKVTLRKDDAYKFLKEAFYAKDYKIPVYSFDKQGNAYFGITDYTDFKGMKYDPDIGIFGMDIAIILKRAGGYRLPRRRIAPKSIPRSIGISKEETIQFLEENFNAQIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1W3</accession>
    <name>A0A1V0N1W3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpmC</name>
        <name evidence="4" type="synonym">rpl29</name>
        <name evidence="5" type="ORF">FAD_0165</name>
        <name evidence="6" type="ORF">HLB00_02245</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000069">
        <property type="protein sequence ID" value="NOL59654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887170.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1W3"/>
    <dbReference type="STRING" id="74969.FAD_0165"/>
    <dbReference type="GeneID" id="16025314"/>
    <dbReference type="GeneID" id="84218654"/>
    <dbReference type="KEGG" id="fai:FAD_0165"/>
    <dbReference type="OrthoDB" id="11736at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050063">
        <property type="entry name" value="Ribosomal_protein_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10916">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35/50S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10916:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="65" mass="7267" checksum="7D9A13E2FB2C385E" modified="2017-06-07" version="1">MELKAKELRAMSDEEINEKLKALKESLLKERSAIAMGGAPASPGTMHSIKKQIARILTVMEEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1X4</accession>
    <name>A0A1V0N1X4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein eL19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl19e</name>
        <name evidence="8" type="ORF">FAD_0177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887182.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1X4"/>
    <dbReference type="STRING" id="74969.FAD_0177"/>
    <dbReference type="GeneID" id="16025325"/>
    <dbReference type="KEGG" id="fai:FAD_0177"/>
    <dbReference type="OrthoDB" id="11624at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01418">
        <property type="entry name" value="Ribosomal_L19e_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033936">
        <property type="entry name" value="Ribosomal_eL19_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="7">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="158" mass="18573" checksum="8565D9CD790802B8" modified="2017-06-07" version="1">MKMSSVKEISADELKVGISRVWIDTNNLDRVLDATSREDIKKLIGLNIIQRRDKKNHSNQRLKKRINQLTKGRRRGPGSVRGTKYARYPRKRRWITTIRALRDELKTLKEKESIDKTTYRKYYRTIKSGSFSSRAQLVSHLKTESLIKEDKHENDTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N203</accession>
    <name>A0A1V0N203_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">MTNA-like protein</fullName>
            <shortName evidence="2">aMTNA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141406.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N203"/>
    <dbReference type="STRING" id="74969.FAD_0210"/>
    <dbReference type="GeneID" id="31675720"/>
    <dbReference type="KEGG" id="fai:FAD_0210"/>
    <dbReference type="OrthoDB" id="45195at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000006">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="338" mass="37387" checksum="8B9CF9839CE1C3B2" modified="2017-06-07" version="1">MKVNINGVSKAILAVWFEDNQVKLIDQRKIPETIEIYSAKNSDDIYYAIKNMVVRGAPAIGVTAAYGLAMASKNKENMEEAVKVISSSRPTAYDLFKAIDFMKANNFSESAAKRYALEITERSRKIGEYGNTLIQANDHILTHCNAGALAVVDWGTALAPMRMAHDAGKKFFVYVDETRPRLQGAKLTAWELQQEGIDYSIIADNAAGHFMKNKDINLAIVGADRIAANGDFANKIGTYEKAVLAKVNNIPFYVAAPGSTFDFSLKNGDGIPIEERDESEVLTVNNSRIGPVEGHARNPAFDVTPNEYVTAFITEYGIFKPGELKKLYSLIHEDLFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N221</accession>
    <name>A0A1V0N221_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exosome complex component Csl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">csl4</name>
        <name evidence="4" type="ORF">FAD_0219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141415.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N221"/>
    <dbReference type="STRING" id="74969.FAD_0219"/>
    <dbReference type="GeneID" id="31675729"/>
    <dbReference type="KEGG" id="fai:FAD_0219"/>
    <dbReference type="OrthoDB" id="6768at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00975">
        <property type="entry name" value="Exosome_Csl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030850">
        <property type="entry name" value="Exosome_Csl4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF034126">
        <property type="entry name" value="PRK09521.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0271">Exosome</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="192" mass="21288" checksum="3663EAC64C808112" modified="2017-06-07" version="1">MEQVNDIVFPGDVIAKEEEYLSGRNTQDIDGNIIATAFGKVSRDDKSLVISVDTQKQAVVIRRYDIVYGKIIKILNKEAVILVSGVDKGKAIVPVATEARLKLPIPNKTMYSHIVTLGDILRAKIVSTRPLYATIFESGLGVLKGRCTVCRSELIADNGKLYCRNCGRIEQRKIAQDYGNINISGVNYERSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N238</accession>
    <name>A0A1V0N238_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">FAD_0231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141422.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N238"/>
    <dbReference type="STRING" id="74969.FAD_0231"/>
    <dbReference type="GeneID" id="31675740"/>
    <dbReference type="KEGG" id="fai:FAD_0231"/>
    <dbReference type="OrthoDB" id="25720at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="8">
        <location>
            <begin position="123"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="249" mass="28925" checksum="543F69559C841260" modified="2017-06-07" version="1">MYYLIKYGYDGTSFTGFQRGNGENSVEDSIIKILKKYGIGNNIESAARTDRYVSARGNVMLVDTDTNIGNVMGILNARIPGMFFYSYSALDSYLNPRHNSLKQYSYIITENIDISRVMETLGEFVGQHDFVNFCKLDSRNTVRTIKSINYSTRNGFYIINIQGRSFVWHQIRSMMAFALMGKKHPFSLENKFTYLASPEPLVLMDISYDNVTFKNFDFKRHNHYLMEKEKITRTGYMLYDIFGENLDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N279</accession>
    <name>A0A1V0N279_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_0311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the Lhr helicase family. Lhr-Core subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N279"/>
    <dbReference type="STRING" id="74969.FAD_0311"/>
    <dbReference type="KEGG" id="fai:FAD_0311"/>
    <dbReference type="OrthoDB" id="33870at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052511">
        <property type="entry name" value="ATP-dep_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="Lhr-like_DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962:SF5">
        <property type="entry name" value="ATP-DEPENDENT HELICASE LHR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962">
        <property type="entry name" value="ATP-DEPENDENT HELICASE LHR-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="WHD_Lhr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="34"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="246"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="899" mass="102945" checksum="1259E0867D50AA95" modified="2017-06-07" version="1">MQQGNVFDMLDPALKESLARNGILNPTEAQKMAIPEILSGENTLLISPTGSGKTEAALVPLLNKIYLEKPQSIALLYITPLRALNRDMLSRVFDYCRTLDIRVQVRHSDISQAERNEISRNPAQILITTPESLQLLMMGKRLREHIKNIKYVIVDEVHEMAQNERGSQFAIAMERLKVLAGNFQVIGLSATAKNEDELSLFISPSSPCKILKPVIDKKMDIKVILPPPSNDDIANIMACDNQYAGSIEKIHSIVEENKGTIVFVNRRYVAEDISFRLRLWLKDPDIEVHHGSLSRETRETAEMDFKENRVKALICTSSLELGIDVGSADMVVQFNSPRQINKMVQRIGRAGHSLQKVSRGIVICNDVIELEEAKAIVGNIKLGELENVMIKKNSLSTVANQIMLELNYSKKVDYNYLYRIITGAYPFKTLEFEEYYAVLELLSRTHKIIIDGNFIIKRYPVLKYFIENISMIAGEKNYRVIDVINKKFIGTLDEKYVVNEISPGSYFVIKGSTWRTIRIDDDKIYVEPFSTAAIAPHWTGEEIPVLYEAASRVSQDRKEKYVPEFLNDRGKKALEEWYKNDMATLDKIIIEAHNSEIIIQILLGSLGNFTLAQILSGLLTSITGESVEMDYSPYHIYMRVSRNISAEDVKNLIMNIDINNLDGYVKSSARRSRFFNNVFLYEARKFGIITNEADITRIRFEKIVDSYYNTVVYEDSIRKLIFDYMDINVLHDYLENLDDSNFILKNKISDSSNIFLSHYSERVMPLKPTKTILESIRKRLMNEEVILYCTSCGNKRTRKIKDITEIRCPVCHSRLVASISKFDEESISKKIDEKTRKRMIKNAHLVREHGITAVMVMAARGVGPEIASRILEVSYLNEDDLIRRLLNAETDFAKNRQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N280</accession>
    <name>A0A1V0N280_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0339</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141511.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N280"/>
    <dbReference type="STRING" id="74969.FAD_0339"/>
    <dbReference type="GeneID" id="31675848"/>
    <dbReference type="KEGG" id="fai:FAD_0339"/>
    <dbReference type="OrthoDB" id="6633at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000001">
        <property type="entry name" value="Siroheme synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004790">
        <property type="entry name" value="PRK06136.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF3">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="429" mass="47870" checksum="1BDE53A3607E58E4" modified="2017-06-07" version="1">MGKAYIVGCGPGNKDLLTIKAIKIIKNADAIIYDHLVNPEILDYATPGTRKIYVGKKPYVKRISQEEINKIIVNEALKYRTVARLKGGDPFVFGRGGEEIEELIRNNIEYEIIPGISSLTGVPESAGIPLTHRNVNHGVLVTTGNSVENLNIPDCRTFNCRMYTLVIFMGAHNLRDIVSRLLSSGYDPALPIALIENGTYNYQKTYTGKLGDIDYSYDDSPSLIVIGDVVQYHKEFSRSEHRIYSGKIVTLFYDLYAPDTDDLENEGITVFKIRCADVFPGNMQTAQLYRKNIAFYGCYTDMLMDILRSSGFDLRWLGKIATDSTGKALLQSYGIFDTTDISESGNDYIWIGSGKEKELQAVKVKPLEMGSYIDDYVKKSDLVIIGGQSDTLPEGIEVKDGAGVIRIEYPYEGLYSKVMSYFGDGDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2D6</accession>
    <name>A0A1V0N2D6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthine synthase</fullName>
            <ecNumber evidence="6">2.1.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dphB</name>
        <name evidence="9" type="ORF">FAD_0348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36415"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="2.1.1.98"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.98" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940586.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2D6"/>
    <dbReference type="STRING" id="74969.FAD_0348"/>
    <dbReference type="GeneID" id="31675857"/>
    <dbReference type="KEGG" id="fai:FAD_0348"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="254" mass="28168" checksum="8F804376BC1A6839" modified="2017-06-07" version="1">MLNIMGLGLRGTKSLTLEEADALKESDLVYFEIYTSISPGNTVDSLSSLTGGMIRLADRNLIETDSEIINEAKNKIVTLLVTGDALSATTHNELRMEAQKAGVEVRIFENASIITAFISKTGLFNYKFGNIVSMPFIYENFFPVSVYDRIYINYSNNMHTLLLLDLKDGKTMGIQDALGILKRMEDSRKKGLIEPERIVIAGIAIGSENESIIYGNLDKVMEYNPPGSPASIIIPATINDNEREFLEAFARKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2E2</accession>
    <name>A0A1V0N2E2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1641 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0343</name>
        <name evidence="2" type="ORF">HLB00_01440</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000040">
        <property type="protein sequence ID" value="NOL59501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141517.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2E2"/>
    <dbReference type="STRING" id="74969.FAD_0343"/>
    <dbReference type="GeneID" id="31675852"/>
    <dbReference type="KEGG" id="fai:FAD_0343"/>
    <dbReference type="OrthoDB" id="56445at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012440">
        <property type="entry name" value="DUF1641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07849">
        <property type="entry name" value="DUF1641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="158" mass="16960" checksum="CA74EBCDB5413883" modified="2017-06-07" version="1">MAGIEKNESSNVDIADIENAIKENADVVMAFMKLLEKLKGAGIVDALNSINENVIPDNLDFFAKAFTSKDSMETFARSGNTLFALLFMLSNRKMADVVKAIAFNSQGIAESMEEGASKPQTLSALKLLAMLKDPEVSSGINAVMNGLKVLGSVLQKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2H3</accession>
    <name>A0A1V0N2H3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0434</name>
        <name evidence="11" type="ORF">HLB00_06940</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000248">
        <property type="protein sequence ID" value="NOL60564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887488.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2H3"/>
    <dbReference type="STRING" id="74969.FAD_0434"/>
    <dbReference type="GeneID" id="16025636"/>
    <dbReference type="KEGG" id="fai:FAD_0434"/>
    <dbReference type="OrthoDB" id="6425at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF13">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="182"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL60564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="416" mass="45500" checksum="7164086650A2F728" modified="2017-06-07" version="1">MENLDPFDIALEQLNKAAKVMKLDKASIDVLSSPREILQVSIPVKMDNGTTEVFTGFRVHYNNARGPMKGGIRYYIKENLSEVKALSAWMTWKTALLGLPFGGAKGGIICDPKKMSKMELERLSRGYIDAIANFIGPEIDVPAPDVYTTPQIMGWMMDEYEKIVRHSAPGVITGKPLTIGGSLGRGDATAKGGMYVLREGAKYKGIDLTKAKFAVQGFGNAGQFAVKFVKEMFGAKVVAVSDSSGGIYKESGIDYAELLAHKEKHGSVENFPGSKNISNEELLESDVDVLIPSAIEDQLTGANASKVKAKIVLELANGPSTPEADEIFYKNNVLLLPDFLSNAGGVTVSYFEWVQNITGDYWTEDVVYSKLDEKMTFATKDVLATHEKYQTDPRTAAYIIAIQRVLDAMKARGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2N8</accession>
    <name>A0A1V0N2N8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141607.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2N8"/>
    <dbReference type="STRING" id="74969.FAD_0449"/>
    <dbReference type="GeneID" id="31675958"/>
    <dbReference type="KEGG" id="fai:FAD_0449"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="475" mass="51146" checksum="EB9989E447323313" modified="2017-06-07" version="1">MVKTGLMRGSVGFWPLVGQTIAFTAPLASVVTSLTGAALYAKGALPLAILIAVISGLIWVNTPYQYSTKIASAGGFYTFTRKAIGPKYGLFDGLIYLMFEYAILANTTLFFSGVLIPAIFSDFFGITVSKYLWIPILIVFVLIFTVLPYIGIKPSVKYALFGSLLEIAILIILSAAIIIISGPKNTGTVFLPELSGGISPLFEGVVLGTFLMTGASGAVYIGEEAKMPRTNIKKAMAVSFVITGALFLLVAYAFTIGWGPTKMGNFATELIPGLILSDKFLGFPFLVVIVILLFNSVFVSMVSPLNVLGRISYSFSRDGVMPPWFVKIHPKYKTPSNAIAFMGISSIVVSVIVGLVYGPFYGYIILITIASLALFAGHIMSDFALPFLYHKLHELNIGLHIILPITSLIVLVFGVYFSVIPPVFPYSLATTATVILIALIGIFVAHFAKKRGKSIEDIGTIEAPLPGSNNEKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2T3</accession>
    <name>A0A1V0N2T3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Flap endonuclease 1</fullName>
            <shortName evidence="12">FEN-1</shortName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">fen1</name>
        <name evidence="12" type="synonym">fen</name>
        <name evidence="16" type="ORF">FAD_0558</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887615.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2T3"/>
    <dbReference type="STRING" id="74969.FAD_0558"/>
    <dbReference type="GeneID" id="16025765"/>
    <dbReference type="GeneID" id="84217157"/>
    <dbReference type="KEGG" id="fai:FAD_0558"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09903">
        <property type="entry name" value="H3TH_FEN1-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 12 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exonuclease" evidence="13">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="12">
        <location>
            <begin position="331"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD84470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="339" mass="37983" checksum="05E83C4C281BE873" modified="2017-06-07" version="1">MGVDISGILVKHQTSIRENGGITVSIDAFNIIYQFLSSIRGEDGEPLKDEHGNITSHLSGIFYRTATLLENNIKPVYSFDGKPYRLKDETLKERKAIKEKNIAELNLAMENKDAEKIKTLSSRINYITADIVSESKKLLDMMGVPWVQAPSEGEAQASYMSKVGAVDSVISQDYDCLLLGARRVLRNFTMYGRRRISGTGKFINITPEIIDLKENLDNLGITQDQLIGIGILVGTDFNPGIRGIGAKTGLSLIKKYGDIESVLKQKNKTIDNLDEIKEFFLNPPVEDTGELKFAPPYREKIIEYLCAEHSFSENRINSILDRIEKNYSGANQSSLDKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2W3</accession>
    <name>A0A1V0N2W3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ni,Fe-hydrogenase III small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887637.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2W3"/>
    <dbReference type="STRING" id="74969.FAD_0580"/>
    <dbReference type="GeneID" id="16025787"/>
    <dbReference type="GeneID" id="31676084"/>
    <dbReference type="KEGG" id="fai:FAD_0580"/>
    <dbReference type="OrthoDB" id="5740at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052375">
        <property type="entry name" value="Complex_I_20kDa-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42989:SF1">
        <property type="entry name" value="FORMATE HYDROGENLYASE SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42989">
        <property type="entry name" value="HYDROGENASE-4 COMPONENT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="7">
        <location>
            <begin position="92"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="199" mass="22144" checksum="93FB65E7635FC26F" modified="2017-06-07" version="1">MNWFLKGVKNRIKTEELEGYRVEQPSFLDGKSDYDCPTDALENGKWDMNRCIFCRECDLKPTGKQTTFTVNRETPHIFEKSLYLYPIDSGTCGACNVEFTTLFSPQYDTNRFKIFMSNTPRHADALVVMGVYTDGMEAVLKEAYDAMPSPKIVIGIGACALSGGIIGSRAMDKYDIEVAGCPPTPASIINAIIKARGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Y1</accession>
    <name>A0A1V0N2Y1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trm112 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0609</name>
        <name evidence="2" type="ORF">HLB00_09675</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000431">
        <property type="protein sequence ID" value="NOL61086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887667.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Y1"/>
    <dbReference type="STRING" id="74969.FAD_0609"/>
    <dbReference type="GeneID" id="25398817"/>
    <dbReference type="KEGG" id="fai:FAD_0609"/>
    <dbReference type="OrthoDB" id="6467at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL61086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13346" checksum="839BF2F1B5C8BE91" modified="2017-06-07" version="1">MQYDLIDLIACPMCRGNSFSKSVIREEGDNVIIPGHGEHTYTDSNNDGANHDMKNGILLCNTCGRWYPIINSIHILLPDTYRDEKKDMEFLTKYKSDLPDIVINNGKPFNIKVLEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N306</accession>
    <name>A0A1V0N306_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-oxoglutarate synthase subunit KorA</fullName>
            <ecNumber evidence="4">1.2.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-ketoglutarate oxidoreductase alpha chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">2-oxoglutarate-ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_0567</name>
        <name evidence="12" type="ORF">HLB00_04155</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 oxidized [2Fe-2S]-[ferredoxin] + 2-oxoglutarate + CoA = succinyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17297"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="1.2.7.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer of the KorA, KorB, KorC and KorD subunits.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000142">
        <property type="protein sequence ID" value="NOL60026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887624.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N306"/>
    <dbReference type="STRING" id="74969.FAD_0567"/>
    <dbReference type="GeneID" id="16025774"/>
    <dbReference type="KEGG" id="fai:FAD_0567"/>
    <dbReference type="OrthoDB" id="31112at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000022">
        <property type="entry name" value="2-oxoglutarate ferredoxin oxidoreductase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050722">
        <property type="entry name" value="Pyruvate:ferred/Flavod_OxRd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154:SF20">
        <property type="entry name" value="2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate/ketoisovalerate oxidoreductase catalytic" evidence="8">
        <location>
            <begin position="12"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding" evidence="9">
        <location>
            <begin position="212"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate:ferredoxin oxidoreductase core" evidence="10">
        <location>
            <begin position="473"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00052359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00064882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL60026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="582" mass="63907" checksum="38C908FD1DA4DE7F" modified="2017-06-07" version="1">MEEIIVRIGGAAGDGVQSAGLTLEKTFSRSGLYISTYNYYQSLIRGGESWYQVRASDEKVRNQGSGLDVLVALNADALERHTNRNINEGGASPLNGIAIYDPGTIHNFKKYDGITYCPVPMRDIALKFDANPLLKNTVALGAVIASLGLDFNVFSGVIEKVFNKKGKLVESNINAAKEGYEYYLQNYKVYRKLKTSNKKLYTIGGGDAAALGAINAGMQMYFAYPMTPASSFLQFVATHGKKYHVFLKLTEDEISAINAAIGANYAGVRAATGSSGGGFALMTEGVGLSAMTEVPLVIYEAQRPGPSTGLPTKTEQGDLNQVLGAGQGDMPRIVLAPGTVKEAFDLTKEAFNLAERFQLPVFVVTDLYLAEHDETVDLDLSYEMDRGLLADASEADYKRYEYTENGISKRAFPGQPGLMHNEDSDEHNEYGAVVSDAITDPTQRKLSMEKRMKKLNLYIKEMPPTPTYKMEDAEYVVIQWGSTKGAVEEAIDCMRKNGTKIGAIEITHIFPMNHDIKKLLAGKKKIIVVENNYSGQLNGLIRKEFLVDTQFLGKYDGEAFFPADLALSLEEMIFGKKIKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N314</accession>
    <name>A0A1V0N314_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Archaeal S2P/M50/PDZ group multipass membrane metalloprotease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0565</name>
        <name evidence="8" type="ORF">HLB00_00665</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000018">
        <property type="protein sequence ID" value="NOL59351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
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    <dbReference type="GeneID" id="84217164"/>
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    <dbReference type="OrthoDB" id="15212at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06159">
        <property type="entry name" value="S2P-M50_PDZ_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="6">
        <location>
            <begin position="121"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="522" mass="56699" checksum="EA81A0C2D5DC4594" modified="2017-06-07" version="1">MNYNDIFLIILIVFSWIIIIIALAPAINKSKHFATMGPALMIRSTKNGGVLDAVAKHLPAKSLGKISTVLVVFGGLLAFGMLLYEAVLLTIIHIPTSAAPPLQDYLALPLINPFIPLGYGTASLVFAVVIHEMFHGIVARKHGIKVNSVGALFFIIPIGAFVEPDEKEIMAADPVVRRRIIAAGPGINLIIAAICIVLLVFVMMPASTPIHSGVYVDNSTTLYSGHAIPKGMEITSYGNLSGKQLNNLETTSMITPGLANITLFNGKTETNGSVPTGVAIVDLISGCPAAAANVSTDSIIYNISDAGHSHIIYNINTLGDVLDNITPGTTINMTVLTFHTGKTVPAYTTYTMKTVSTYHYYAKNDPTANKAAYKNESFIGVQIDYSGIGYESIDSLHSLVFGGQLVGPNFYETLGLPLLGLSPIPASLSHMFSTPFNSYIFFGITNTLYWFFWIDFLLGIMNALPLSILDGGQFFRDTLTIASRRDRLKFLRDENNVKKIYYAMGIFVFLLLMYIIIAPRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N350</accession>
    <name>A0A1V0N350_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0658</name>
        <name evidence="11" type="ORF">HLB00_09915</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000440">
        <property type="protein sequence ID" value="NOL61133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143146.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N350"/>
    <dbReference type="STRING" id="74969.FAD_0658"/>
    <dbReference type="GeneID" id="84217260"/>
    <dbReference type="KEGG" id="fai:FAD_0658"/>
    <dbReference type="OrthoDB" id="18209at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03257">
        <property type="entry name" value="ABC_NikE_OppD_transporters"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oligopeptide ABC transporter ATP-binding component"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050388">
        <property type="entry name" value="ABC_Ni/Peptide_Import"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43297:SF14">
        <property type="entry name" value="ATPASE AAA-TYPE CORE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43297">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORT ATP-BINDING PROTEIN APPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="3"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL61133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="322" mass="35893" checksum="8C707CA7FCA7C500" modified="2017-06-07" version="1">MFLEIKDLKVSYKTVNGKSTVLNNFALNLDKGDSISIVGESGSGKSTLGGAITRLLPPSGEESGEIVLDGKDLLKLSEDEMTLIRGTEIFMIFQNPLNSLNPVKTVGYQLIEAAKIKAERDKSDATEEHLNNVIIQALKSVRLPDPEQIIKRFPHELSGGQVQRVVISMALILRPKLLIADEPTTALDVTIQAQVINLLKEMNRDYGMSIIFITHDLSLAYVISNKIMVMYAGTIMEFNGSDLLVKNPRHPYTIALLKSVPTDYKTNSKLYYLKGAPPSFFNLPRGCRFHTRCEKVFGKCEVEEPPLISIGGDYKVRCWLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N353</accession>
    <name>A0A1V0N353_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8 10">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nadE</name>
        <name evidence="12" type="ORF">FAD_0675</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>deamido-NAD(+) + NH4(+) + ATP = AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="8 10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N353"/>
    <dbReference type="STRING" id="74969.FAD_0675"/>
    <dbReference type="KEGG" id="fai:FAD_0675"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010587">
        <property type="entry name" value="PRK13980.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD/GMP synthase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="253" mass="29295" checksum="6E582043E1E69E8C" modified="2017-06-07" version="1">MEVNIYLTLFYYHNVKDIYVDKIQVIREFLKEKIGEKHAVLGISSGIDSSLVLTLLATSIDRNKIKAIFMPDKYTKQDDYEDIKKLSDSTGLDIITINIENVFESYRALLNTSDKKLEGNIRSRIRANILYYHANLLGGLVIGTTNRTEYLLGYYTKYGDGACDIEPIEDVFKTDVWKIASILKVPQSIIDKKPSAGLWENQYDEDELKMDYHEIDKILSDIFDNHTLNGKYEKLMELYLKSMHKRELPKAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N361</accession>
    <name>A0A1V0N361_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
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    <dbReference type="GeneID" id="31676133"/>
    <dbReference type="KEGG" id="fai:FAD_0628"/>
    <dbReference type="OrthoDB" id="19089at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="300"/>
        </location>
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            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="406"/>
        </location>
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            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="7">
        <location>
            <begin position="129"/>
            <end position="430"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="498" mass="55414" checksum="BBD4EA25197D600B" modified="2017-06-07" version="1">MILLYFFILFFILTGLSFFAGKHSKSVSLVSLGILTVFFIIYSIFDFRNYTGGVISYYNVLLTSFSTSGITININFSLGLTGFSDLLVIIALLITMFSILMGSKSHGAYFYGLFMAAGFGLAGLFMVRNFLFFYIFWEVVLIPVFFIIGKYGTGNKEKSSLKFFIYTHIGSLFLLLSIFTLSTYYFLKTSIFTFQIGDLMNVAFIIGIPTYAFYFILFGFLLAFLIKLPTFPLHVWLPDAYYDAPYSGTIMLSGGLVAMGGYGLLGILYPIAGLFPKYLVYFIIFLGLISIIYFAFSALFQPDLKRMAAYGSAAEMSFITIAFGTALLSTGYVRTLDLAGGMYQIIAHTFVAALIFASLSLVYKRTGTSRIYELGGLNRELPILSSFLLVGMLASLGLPSLAGFIGEFSVTISAFQSIGLYTLFIVLGLIVIAAFLIWAAQRTIFGYFNERLGRLRDVNKQEFLILFFIMVCTIFLGVYPTLFFKILTAYASHLGGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N364</accession>
    <name>A0A1V0N364_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141736.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N364"/>
    <dbReference type="STRING" id="74969.FAD_0633"/>
    <dbReference type="GeneID" id="31676138"/>
    <dbReference type="KEGG" id="fai:FAD_0633"/>
    <dbReference type="OrthoDB" id="9577at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF15">
        <property type="entry name" value="BLR3095 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="50"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="372" mass="41859" checksum="3232194781EEEBDD" modified="2017-06-07" version="1">MNKEKIRELFYNLDNVNHLAACSKSPMLKTVKSSMENYMKDVIELGNPWNLWTEKVEKARELFAQLIHADKKDIAALYSVSSALNSIMGSMEFSNRNEIVTSDMEFPTTNFALYGYSKYGAEIKTIKSSGNTIDIDNYNGAINKNTLMTTAIHVSSLNGFRQDVGKIASIAHENGSYIYVDDYQSLGGVNIDVKKSKIDFLASGNLKWLLGVSGVAFLYVNPEIVETLKPANIGWFSQKNPFEFGAESLNYAEGARRFENGTWAIPSIYASIEGMKAILDYYDYIEKEDRKLFQHAIDSLERNGIPTITPDEAANIIAIPMKNPGDAEAMLKKKYKIITSARGDSLRIAPHFYNTEEEISEAIEKIKFEFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N378</accession>
    <name>A0A1V0N378_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF167 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887700.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N378"/>
    <dbReference type="STRING" id="74969.FAD_0640"/>
    <dbReference type="GeneID" id="16025850"/>
    <dbReference type="GeneID" id="31676144"/>
    <dbReference type="KEGG" id="fai:FAD_0640"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7769" checksum="F3106C95CC760FD1" modified="2017-06-07" version="1">MIVVNGKHRIESEGDRLKIYTSAPRENNKANYDIMKQLATYYNVEFYKIKLISGQKSRKKIFSIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3B7</accession>
    <name>A0A1V0N3B7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_0684</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141788.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3B7"/>
    <dbReference type="STRING" id="74969.FAD_0684"/>
    <dbReference type="GeneID" id="31676185"/>
    <dbReference type="KEGG" id="fai:FAD_0684"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051084">
        <property type="entry name" value="H+-coupled_symporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="432" mass="47208" checksum="E3B5C69B208C6FCC" modified="2017-06-07" version="1">MSENKFIGFTRNELLQVSAAWGGWILDGYTSIAYLLVFSYISVLIFPKYLGYLALILTLLPVTFGAAARSVGSVILGNFIGDRKGRKNLLSISIIGFSVLSAAIGLLPTYSQAGIASPILLYALLFLDGIFAGAEYGGGTALSMESVSPEKREQAGAFVQSGYGTGYFLIVFVEILLLRSMGSAAFASYGWRILMLTAIIPGVITLVIRRLSKETEVFDRMKAENSIEKSPVRKMFKNRSSIVFGFMITAGLLFMNTATASFYPVVGSVDFLNLGSGLLYALLVINFFSLIGVWSGGILARSFRDRRRPMLIFSIIFTVPTALFVIFGYTTNIMDFTIVFSIQLFLEALIFSALPVFLAESFSKKFRSTAVGLIYNGGAIFGGTAIVLLTAPAHIINIRTLWIVEVYIAGIILILGLIFYKKQENTSDPIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3D5</accession>
    <name>A0A1V0N3D5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Malate oxidoreductase (Malic enzyme)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">NADP-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0703</name>
        <name evidence="6" type="ORF">HLB00_02815</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000091">
        <property type="protein sequence ID" value="NOL59766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141812.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3D5"/>
    <dbReference type="STRING" id="74969.FAD_0703"/>
    <dbReference type="GeneID" id="84217326"/>
    <dbReference type="KEGG" id="fai:FAD_0703"/>
    <dbReference type="OrthoDB" id="45556at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004470">
        <property type="term" value="F:malic enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051674">
        <property type="entry name" value="Malate_Decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43237">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43237:SF4">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="3">
        <location>
            <begin position="169"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="435" mass="47611" checksum="AB3C3E7ED7A4BFE7" modified="2017-06-07" version="1">MIMKDSERTEYFDKTAIEISKKYRGKIRTLSKVPITGMGDFSSLYTPGIAAVSKKIQADKELVYELTGKWNSVAILTDGTRVLGIGNVGPEASIPVMEGKALLFNYLGGVNAIPIPLVVNNNEEFITAAKAIQPYFGGYNLEDIQSPRCFFLLESLQKSMDIPVWHDDQLGTASIILAGVINALRILNKKKEDVKIVFNGAGAANIAAIYLFGAAGFDKGNIIAIDSKGIIEPDRQDIDALMFKNPWKYKIALETNKERVKGDPANAFKGADVVISASVSVPGTIKDEWIKSMNRDPVIFALANPLPEIWPGDAKKAGARIVATGRSDFPNQINNSMVFPGVFRGVLDARAKGVNFGIMVAASYAIADFIENPTEDHIVPSMEDFDLFPRVASIVARKCVESGLARKSDSTEGFYREASEIINNNRKVYNKLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3E2</accession>
    <name>A0A1V0N3E2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0776</name>
        <name evidence="9" type="ORF">HLB00_01900</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000049">
        <property type="protein sequence ID" value="NOL59588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887872.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3E2"/>
    <dbReference type="STRING" id="74969.FAD_0776"/>
    <dbReference type="GeneID" id="16025995"/>
    <dbReference type="KEGG" id="fai:FAD_0776"/>
    <dbReference type="OrthoDB" id="116110at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050201">
        <property type="term" value="F:fucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042352">
        <property type="term" value="P:GDP-L-fucose salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052203">
        <property type="entry name" value="GHMP_Kinase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="HddA/FKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014606">
        <property type="entry name" value="Heptose_7-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463:SF0">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036406">
        <property type="entry name" value="Hept_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="6">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="7">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="329" mass="36668" checksum="0EA5E2A327D7CC15" modified="2017-06-07" version="1">MITVYSPLRISFAGGGTDISPFYERYGGAVLNTTIDRGIMIRYEDDGSSLEVSSRDFLRTALISTNNRTMENKIIDMFMENGINTGRVIMNSDVPPGSGLGSSSALINGILKMINAIKKRNVDPYELAKESYLTEKDKFNIILGKQDPYAISIGGLKYMEFRENVDSTQKFDLSDPFVKDLQSSILLVYTGNTRESSRSLQDQVTKSEHGDEQTMENLNKIKHLALEMSKAISAHNRNEVCNIINEGWNIKKSLGANVTNQRIDEIISYAKENGAKSAKLLGGGSEGFILLIGEKNGIDSLQRKMMLKSDFVIRVRFDNCGTRVINNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3E5</accession>
    <name>A0A1V0N3E5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887860.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3E5"/>
    <dbReference type="STRING" id="74969.FAD_0768"/>
    <dbReference type="GeneID" id="16025986"/>
    <dbReference type="GeneID" id="31676271"/>
    <dbReference type="KEGG" id="fai:FAD_0768"/>
    <dbReference type="OrthoDB" id="44243at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513">
        <property type="entry name" value="INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="404" mass="45669" checksum="465CDF091F819BEB" modified="2017-06-07" version="1">MLTSDLYRHNRNAYARYLISRNIARFSNTAYYIYFMWEIIANYHSVLLVSLIPGFSFLGYLIIAIPEGSIIDRYDRHLIYIGINILMVLTYSILFFGRSLFIIYAVDFLSSTFMWVVSDDFRALTKEIMPADHMAKAQSADQLSSGIFTLAGIILGGAFIFMRYSTVYVALIGISIFALAIIFVPRTIKVSHRSIVKNGFRSTVKIMKNILPFLLLTLLLNGMFVAIDVFASGLINIIMHASSIYYTFFIAGFPAGMLAGGLISMHGFYRPYQRNKRMMAFYIFMTGVIFILISFNRLPVMDGILTFLSGVILAFINVYIETMIINSIPSSITGKFNALTAMFSVSSSPVMAFVFGELSRFLYFPYIITVVGVIMLLSSFTVIKIMEGFNSAMEKIEKENPELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3G5</accession>
    <name>A0A1V0N3G5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-hydroxybutyryl-CoA dehydrogenase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3G5"/>
    <dbReference type="STRING" id="74969.FAD_0733"/>
    <dbReference type="KEGG" id="fai:FAD_0733"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="50"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="207"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="304" mass="34278" checksum="6B2DB187A3253B50" modified="2017-06-07" version="1">MGSSIAEVFAFNGYSVYLKDQNMEYVNRGISHVRKVLEDYQSYMDSMPDKEIKRIERNGIELTETQKNSIKKNLGKQLDIDGIISNIHPVESYKELSQCGLVIEAVFEKQEIKNDLFRELSGYFGENTILASNTSSLSITEMAANYKYPENNIIIHFFNPPYTMPLVEIVPALQTGSKTVETAYSLISGLRNHRDTMVPVKAKERSGFIVNRILIQLINEAIKIVEEGIADEKSVDIGMKKGAGFPMGPFELGDYVGLDIVYDVLKSFNKAYGDAYIPPERLKNMVIAGYLGRKTGKGFYEYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3G8</accession>
    <name>A0A1V0N3G8_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0721</name>
        <name evidence="3" type="ORF">HLB00_01155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="NOL59445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141846.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3G8"/>
    <dbReference type="STRING" id="74969.FAD_0721"/>
    <dbReference type="GeneID" id="84217344"/>
    <dbReference type="KEGG" id="fai:FAD_0721"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="66" mass="7484" checksum="2890033BED30AE9F" modified="2017-06-07" version="1">MENKRVKNLIKVNIIIGIITVIEVSYIISHFKLYLAHVLPIDILSIVLGMSFAVTMFLWVVGITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3J1</accession>
    <name>A0A1V0N3J1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclic pyranopterin monophosphate synthase MoaC</fullName>
            <ecNumber evidence="5">4.6.1.17</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor biosynthesis protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moaC</name>
        <name evidence="4" type="ORF">FAD_0757</name>
        <name evidence="5" type="ORF">HLB00_06815</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="NOL60542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141924.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3J1"/>
    <dbReference type="STRING" id="74969.FAD_0757"/>
    <dbReference type="GeneID" id="84217377"/>
    <dbReference type="KEGG" id="fai:FAD_0757"/>
    <dbReference type="OrthoDB" id="10067at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01419">
        <property type="entry name" value="MoaC_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023047">
        <property type="entry name" value="Mo_CF_biosynth-C_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008999">
        <property type="entry name" value="PRK12343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin cofactor biosynthesis C (MoaC)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="146" mass="16234" checksum="4A4C34F41DE18CCF" modified="2017-06-07" version="1">MIDITDKNTVKREAMATGTIKLNKETIKLIREKQVKKGDVIETAKIAGTIAVKNTSGMIPYCHPVPVMSIDFNFEVEDSKIVVTCRVKAIYRTGVEMEAINGVQVALLTIWDMVKYLEKDETGNYPDTSIGNVAVVYKRKGDAYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3M4</accession>
    <name>A0A1V0N3M4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142090.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3M4"/>
    <dbReference type="STRING" id="74969.FAD_0866"/>
    <dbReference type="GeneID" id="31676369"/>
    <dbReference type="KEGG" id="fai:FAD_0866"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="61" mass="6873" checksum="FA77FC6E09136156" modified="2017-06-07" version="1">MIIQTVPPDLNGNMVKKFFSCQICDIFSNNIHTKSKYSSGDIVNTLWNPTALKMYIGTYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3M8</accession>
    <name>A0A1V0N3M8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951103.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3M8"/>
    <dbReference type="STRING" id="74969.FAD_0772"/>
    <dbReference type="GeneID" id="58788991"/>
    <dbReference type="KEGG" id="fai:FAD_0772"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="54" mass="6244" checksum="9435696F93DB65A7" modified="2017-06-07" version="1">MPEIFVRDEIYKNIADSHSDVSKFVNNVLGQYLDAFKPESRDVMDHYTKHGNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3N2</accession>
    <name>A0A1V0N3N2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Y</strain>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
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            <strain evidence="2">Y</strain>
        </source>
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        </source>
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    </evidence>
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</entry>
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                <person name="Tatusov R.L."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
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    <organism evidence="4 5">
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3W3</accession>
    <name>A0A1V0N3W3_9ARCH</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">FAD_0902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
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            <authorList>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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    <dbReference type="KEGG" id="fai:FAD_0902"/>
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        <property type="component" value="Chromosome"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="194" mass="21340" checksum="D1554FD93E46B33F" modified="2017-06-07" version="1">MVVDAALPPLAIGFFGLGIGYYVFGGAGFFRFPKENNDNINHAMGLWGIFMPGFMQFIAGTYIFLGLTIFPAFRSTPILYMAGLAFTSYGVHWFALGYNKYKGADTTVDGFMAVGFLWISIIGAVVFGLGHDIPVMILFILLAIIYLNDIPASLFHSPAWGRGKALFQLITGTWLMYLTFAAALNFALGYHLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N400</accession>
    <name>A0A1V0N400_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142316.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N400"/>
    <dbReference type="STRING" id="74969.FAD_1001"/>
    <dbReference type="GeneID" id="31676500"/>
    <dbReference type="KEGG" id="fai:FAD_1001"/>
    <dbReference type="OrthoDB" id="383016at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="167" mass="17647" checksum="34DEFBFDDF89B5EB" modified="2017-06-07" version="1">MVNKKYLIVVPIVAVILLSSIIFVPYSTSIPGNQYSASNSGSQPAYMNITSITLHDGVITPCLLNGTYHITAVSANLTSLSLIHITASNGKVNITATSGNLTGLNLWSNSLGFSVLDTAVDGILTPITSITGVISGNITIQDATLEPTYFHADYQDLSNSNINMDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N419</accession>
    <name>A0A1V0N419_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142338.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N419"/>
    <dbReference type="STRING" id="74969.FAD_1012"/>
    <dbReference type="GeneID" id="31676511"/>
    <dbReference type="KEGG" id="fai:FAD_1012"/>
    <dbReference type="OrthoDB" id="57427at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="251" mass="29173" checksum="A389AA10E3A987EA" modified="2017-06-07" version="1">MVINYDGFLSSWELQQNALIEMREERFSFMMDVIEETHPEVNRILDAGCGPASFSVRLAERFKDARIYSIDYDPVLLKLAKSNASIYGSRVKILEYDLKGNAWAKDLADEGFDAIVSTTALHWIPRNNLSNVYENFYKLLKDGGIFMDGDHFRSNTDSVDLHDMYSKIRNNISALNISRDKAMNWEEWWEYILNSGVFREELMERSKRYASGSHDQNVSLEEHIDLLKHTGFSSTGVIWQYLDNRVLFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N455</accession>
    <name>A0A1V0N455_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N455"/>
    <dbReference type="STRING" id="74969.FAD_1047"/>
    <dbReference type="KEGG" id="fai:FAD_1047"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23528">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23528:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="417" mass="46256" checksum="D545FD7FD3A20E8E" modified="2017-06-07" version="1">MNEHSLKSFRYIFGMNSVYLGNNYLWTSFESLFLPYVIELLVPSRLQTIYLGIIAFAGIIIGIAFNFLSGSFSDKFHSRYGRRRPMILIGSIIVIFSLLLFIIIKETIVTIFIIYILIEIGSNIAYGSYQPLIRDIIPESQRSTSSGVGGFFTLIGSAFGFGLSGVLIGTGRIELATVLILITIAAGSIITIFTIKREDYISSSEIIHRKLSGVIKNFKQSTKFKWMAIANFFITTGSSGLVFFEYYYFEYSLDLKDTAIYVAIAGVTILLISALSTVGIGILADKINKEIFLLIFPLISGFSILFISFIHAFYLFLVLGSLIGIAYGNYFTITNSYMSFIVPHGSAGKYLSIFLVSTEIGAAFSPLIYGLVLFLFRGMGSAEYSRLFELSSIFYFIGFALILLKVVNIQGTANGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N456</accession>
    <name>A0A1V0N456_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886140.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N456"/>
    <dbReference type="STRING" id="74969.FAD_1049"/>
    <dbReference type="GeneID" id="16024267"/>
    <dbReference type="KEGG" id="fai:FAD_1049"/>
    <dbReference type="OrthoDB" id="115601at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="405" mass="46424" checksum="0B06E0ACA05D4E9E" modified="2017-06-07" version="1">MADKSIDKQVDKYYNEAMKLFNDEIYDKAILPLTRAIKLDNGNPEYYEKRSWCYIYTDESKKAIEDIDKALSIVKKPEYYIAKAYALINDNNNSEAYTALDTAINMAPGNPDYHSIKGDLLLDDKKYGPALEQYNTAIKILPGVYQFHYGKAMAYSYMEKFPEALEEYNRVIEIEPNFGEAYYNRSIIYLDQDKFEDAIRDAERAMDLESDVPDNFDLMGNILAAMEKYEEALKYYGEAIELDSRFAAAYYDMGIMYDNMKNYSNAIENYDKAIKLVDNYYEGTKSPSNAAIPAFLKKANDLYLLNKADDAIATYEQAFKREPGSVIIPVKMGHILFELARYSDVVSLLSPIFSYGLKTIKKMCAEDECEDNHLISGLNDLINSCNATGKTQNVKLYKKLLDDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N461</accession>
    <name>A0A1V0N461_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">Major facilitator superfamily permease</fullName>
        </submittedName>
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    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
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            <taxon>Archaea</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513">
        <property type="entry name" value="INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ARD84877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="408" mass="46210" checksum="24CDBB584C8E4892" modified="2017-06-07" version="1">MQKNFFYLILSTLIANIASSILYIGITWYVLISVNGEILYGSIVLIATITGFAISNFIGKIIDRYNKKKIFIQLHLIVSLLFLLIFLLLIRNIALSITTLFIIYMIISVYSMFYWNVILSITQQIFSIKEYKSINSKMEIIGQISSVFSIIAGFIIYSVNFLFIMIACSIAFAISAMTFKKIKIIEAEKNNISKSTFSGFTYLKNNKYLFFLLFALYTPFIAIIIGNFTQPAFIVNALNGTPVIIGAMESIYAISAVITSLLIPKMNEKNEFILIVISMIVFSVGTIAMGLIKIVIIFLGLEAIQGYGNPAIRIIRKTIMMKTIPKKFIGRVYGSLETISYIARISFLAIYILIIKYTGSGILIAIQGIFVLTFVFVVIYSLRKMQIKAQPDKNPKRFYLSGYYQKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N462</accession>
    <name>A0A1V0N462_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">Amino acid/polyamine/organocation superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142340.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N462"/>
    <dbReference type="STRING" id="74969.FAD_1013"/>
    <dbReference type="GeneID" id="31676512"/>
    <dbReference type="KEGG" id="fai:FAD_1013"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="131"/>
        </location>
    </feature>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
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            <end position="232"/>
        </location>
    </feature>
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            <end position="275"/>
        </location>
    </feature>
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            <end position="310"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
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        <location>
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            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="495"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ARD84894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="520" mass="56309" checksum="961AE20F5EA38DEB" modified="2017-06-07" version="1">MVDNKTKQYSNRLMTGQVGTWGAIAEEISAMAPACDSIAFVVSSAVFAFFLTPLSFIIATLTMFLEVNTLYHLSKRHASAGGYYGYIANAFGPVPAISAGLMYPMYQTVSTAAIPVFVAGVVLPGVVMYFLGVGMPAWIWIPFILAFIIVPIVIAIVGIRPQMKYIRVAGFFEIIFLAVLSAIIIIKAPDNTLNVFNPFAWPQYSSWFAPEGGVFTGVGLGMIFGLTSFIGYGGSAPLGEEATNPKAITRSLTFGLFIVGIVMTEVAYAQIVGWGIPLIQTFSSSGIPGIIVATTYTGIVGGVMFALVAFNSAFSDGVAMQANAGRVYFAMGRDGIIPKFFSFIHKKYVTPSKALIFVGVVSSIVAVLSTFIVAMGAGVSPYALMDNKASDPVIIKALTDTFQFLTTMALAGLIITHILLNTSVMTMFRRLKEKHTGIRDVVLHMTQHYLFPSIATVIFIFVLYESVVPPVYPITYAILIIGVYTVFSVVYALYIKYKKPELAKKAGKYVNIVDEEHDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N465</accession>
    <name>A0A1V0N465_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-aldohexose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N465"/>
    <dbReference type="STRING" id="74969.FAD_1020"/>
    <dbReference type="GeneID" id="31676519"/>
    <dbReference type="KEGG" id="fai:FAD_1020"/>
    <dbReference type="OrthoDB" id="24596at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005007">
        <property type="entry name" value="PRK06398.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="258" mass="28100" checksum="B915FC2E78B922E2" modified="2017-06-07" version="1">MYDDLKGKNVLVTGGSKGIGRAIALRFLEEGANVMSISRNIPEDTDDRITYYNCDVSGSNDVKSTIENILSKFNGIDILVNNAGIEEYARLDKTDEGMWDRIMDINVKGVYNVSKYCIPEMIKNHSGNIINISSVQANIITKNAAAYVTSKHAIIGLTKSIALDYAPEIRCNAVLPATIDTPLVRKAAILEVGNNEEKIKDKIREWGLQHPLGRIGKPEEVANTVLFLASNQSSFITGASIMVDGGLSIKAPISTPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N479</accession>
    <name>A0A1V0N479_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type sugar transporter, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N479"/>
    <dbReference type="STRING" id="74969.FAD_1026"/>
    <dbReference type="KEGG" id="fai:FAD_1026"/>
    <dbReference type="OrthoDB" id="18368at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000042">
        <property type="entry name" value="Maltose/maltodextrin ABC transporter, ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047641">
        <property type="entry name" value="ABC_transpr_MalK/UgpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43875">
        <property type="entry name" value="MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MSMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43875:SF15">
        <property type="entry name" value="TREHALOSE IMPORT ATP-BINDING PROTEIN SUGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="MOP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="351" mass="39513" checksum="DE770DE22F0A3016" modified="2017-06-07" version="1">MADVKVIDVYKSYGKVPVLKGLNFDIENGEFFVLLGSSGSGKSTTLNILAGLDTMDSGKILFDNNAVNQLSPVERGVAMVFQNYALYPHMTVFKNMAFPLKMLNYKKESIIRIVNEVAKTLDITTLLDRYPRELSGGQAQRIALGRALVRDPKIFLLDEPLSNLDANIRSKIRNELKLMQEELNRTFIYVTHDQMEAMSLGDHIGILHNGLLEQYGKPIDIYNNPVNEYIATFLGDPEMNMLSCRKNGNIYEGECSIQFKLNSEDKNITLGVRPENIYLHKQNDDDIEGKIVPKISELLGSRTLIIGMAGSDKEIKIITEESDISIGKEIPVYFNLNKCHVFNEKGDNINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N485</accession>
    <name>A0A1V0N485_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose 1-dehydrogenase</fullName>
            <shortName evidence="9">GDH</shortName>
            <shortName evidence="9">GlcDH</shortName>
            <ecNumber evidence="9">1.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gdh</name>
        <name evidence="12" type="ORF">FAD_1034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose + NAD(+) = D-glucono-1,5-lactone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14293"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose + NADP(+) = D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14405"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142389.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N485"/>
    <dbReference type="STRING" id="74969.FAD_1034"/>
    <dbReference type="GeneID" id="31676533"/>
    <dbReference type="KEGG" id="fai:FAD_1034"/>
    <dbReference type="OrthoDB" id="41394at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047934">
        <property type="term" value="F:glucose 1-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047935">
        <property type="term" value="F:glucose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019595">
        <property type="term" value="P:non-phosphorylated glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08230">
        <property type="entry name" value="glucose_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02127">
        <property type="entry name" value="Glucose_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026583">
        <property type="entry name" value="Glc_1-DH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43189:SF2">
        <property type="entry name" value="GLUCOSE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43189">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1198.01-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="10">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="140"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="358" mass="40054" checksum="805F4A07B1431A51" modified="2017-06-07" version="1">MQAITVKPPEAGITFQNLNYKSNGIKIKILENGICGTDREIVKGQLNSAALPPQSDYLILGHEAIGTVVEDGNIFKKGDIVMPVNRRGCGKCLNCLVGRPDFCETGNFVEAGIKGMNGFMSEYIYDDEKYLVRVPADIKNMAILAQPLADLEKSMDEIINIQKRMIWKCNDNTFHCRNALVIGTGTIGILFSLLLKTYGFSVTIANRRYAHEKESKIFNIADIKYYNSANGYNFENNSFDLIIEASGSSADVISETMGLLKNNGIFGLFGFIRSGELSINSHMLQDFVYKSIAMVGLINGQKPHFEMATDHLMQWKSMYPGIEKLLITDEIQISDREKITTALTEKSKDEIKTRILWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N494</accession>
    <name>A0A1V0N494_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">FAD_1050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886143.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N494"/>
    <dbReference type="STRING" id="74969.FAD_1050"/>
    <dbReference type="GeneID" id="16024270"/>
    <dbReference type="KEGG" id="fai:FAD_1050"/>
    <dbReference type="OrthoDB" id="55875at2157"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="9">
        <location>
            <begin position="242"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="268"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="380"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="506"/>
            <end position="509"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="598" mass="67669" checksum="6F353A4C3E34F465" modified="2017-06-07" version="1">MGDIENISKNPENQLKMLLFHRNPELNGRLETFVRMLEPANIVVITDPDFYEKKLVGEMATDHELIELNRKYYSNSYLYRSNPDDVARTEKDTYISSLDEKNAGATNNWMEPEHLKSRIFNLIKGSMKNKTMYIVPFILGPAGSKYSEAGIQITDNPYVVINLIKISLVGKEAINRIENTGKYVVAIHVTGTLDKNNRYIAHFTDEDLIISVNTAYGGNALLTKKGYALRIASVHARDNSRMAEHMMALEVTSPSGRKYGISGAFPSASGKTNLSMIRTPTDMAGWDAQLLSDDIIWMHINNDSLYAINPEYGFFGVAPGTNATTNPNAMKAFNRDTIFTNTALTTDGKPWWYSLDPSVSEVYDWHGNLTTDLKNAAHPNSRFTTPIKNYPYLSSKFYDNEGLKIDAMLFGGRRSDLIPLVRQAKSWAQGVLFGAMIRAETTAATTGKVGILRNDPMAMIPFCGYNIGDYFQHWLDMGKLVQHRPEIFYVNWFRKDSDGNFIWPGFSENFRVIEWIASRLDAKANAIETPVGLIPDIANFASGNLGKNKLEQLFEIDYPGWLKELNEIEPFFKKIGDSFPEELWREFHNMKDGVEKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4B6</accession>
    <name>A0A1V0N4B6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">FAD_1070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142443.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4B6"/>
    <dbReference type="STRING" id="74969.FAD_1070"/>
    <dbReference type="GeneID" id="84217670"/>
    <dbReference type="KEGG" id="fai:FAD_1070"/>
    <dbReference type="OrthoDB" id="134160at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="168" mass="19207" checksum="6915595C30E76FD8" modified="2017-06-07" version="1">MKFNVQTENFPESFYVFIEIPQGGNTKLEYKFDVENIVLDRILFTSMVYPTNYGFVLNTKAKDEDPLDVLVISSVPIPSGTIVKCRAIGIAEMSDEEGSDNKVIAVPLDKVDPMSKEYTDIKDVPDAVKDKIKHFFQHYKELEKGKFMTFHDFKGKDEAIKQIKESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4B9</accession>
    <name>A0A1V0N4B9_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
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        <lineage>
            <taxon>Archaea</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ODC_N"/>
    </dbReference>
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        <property type="entry name" value="PRK06407.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="296" mass="32832" checksum="EDE1E61699298683" modified="2017-06-07" version="1">MITYVTEEDVKSNLKMGECIEELRKAFKSYGNGASDAHPRDRIMNNNSMLNTMPGVYGARHLAGLKTYYAGPSGIHFVVIIFNTEKPEDLYILEANTLGQIRTGALAAMATSEVVKERAINFTLIGSGFQAESQFLAMKEIFNLKHAHVYSKNPSHSKAFADKFGIESVDSLDVLKESDVITSITNSNSPIFNYSQLPERYHINLAGSNFPIRREAAPDVLDNSDVVIVENLEQAMKESAEIMGVQKKEKIVELKDYMINKGKYPGNKTIFKSMGIGLEDVAAGYVILKNMGIINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4G6</accession>
    <name>A0A1V0N4G6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4G6"/>
    <dbReference type="STRING" id="74969.FAD_1119"/>
    <dbReference type="GeneID" id="31676616"/>
    <dbReference type="KEGG" id="fai:FAD_1119"/>
    <dbReference type="OrthoDB" id="134118at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="229" mass="26350" checksum="1D79CDCF1DCE6A8C" modified="2017-06-07" version="1">MIRKANVEDWESISSISARAGYDDYINKEVGIAYLYGHDVYVHISQEIDGFIKLEPLDDKSLWFSGLRVDPESRRKRIGTKLLKFALDHAINNGYKSLRCMVETNNIPSIRLMESFGLSVVDKYFFFSGGIDISYFEKSYSYSGNYANKEWKFDSVYETVYSQGNRQVYLHAGRMLYYTVLSGDEFKYTDEGSTCAPESIAPFIKLQPDYGFKSGYIFEMGTSHRPDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4H5</accession>
    <name>A0A1V0N4H5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin (MPT) converting factor, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142503.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4H5"/>
    <dbReference type="STRING" id="74969.FAD_1128"/>
    <dbReference type="GeneID" id="31676625"/>
    <dbReference type="KEGG" id="fai:FAD_1128"/>
    <dbReference type="OrthoDB" id="45235at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="136" mass="15450" checksum="845BA66D5832F365" modified="2017-06-07" version="1">MIKIQEEKIDHETLVNEVKNDKAGAIVTFYGTVRSIDETSDDIIALIYEAYEEMAIKKIQEIIKDAQKKYPVINVAVIQRIGRINVGEDSIGIAVSSEHRDSAFHACEFIIDKIKILPPIWKKEVYSSGEVWRSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4H8</accession>
    <name>A0A1V0N4H8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoserine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1135</name>
        <name evidence="10" type="ORF">HLB00_04830</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000164">
        <property type="protein sequence ID" value="NOL60160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886239.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4H8"/>
    <dbReference type="STRING" id="74969.FAD_1135"/>
    <dbReference type="GeneID" id="16024364"/>
    <dbReference type="KEGG" id="fai:FAD_1135"/>
    <dbReference type="OrthoDB" id="10041at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006386">
        <property type="entry name" value="HAD-SF_hydro_IB_PSP-like_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01491">
        <property type="entry name" value="HAD-SF-IB-PSPlk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0718">Serine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL60160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="212" mass="24367" checksum="AD020AAF1D9F7A8A" modified="2017-06-07" version="1">MIKLIFFDMDGVLTVEKSSWFYVNNRLGINNRENYLKYISGKLDYYDFFRMDIAAWREKYPEITMEEIKGILDEIPVIPGIEKCMAYLKKNKIISVIVSGGISWLSDRLKNSFGIDEAYANRIFSDHEGKLIPEGEVQVNPMRKDIVMEKIMAEHNVSPKDCIALGDSESDYSMYKAVNNFIAFNSDSDLLSRVARINLSGNIDSIIDYINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4K8</accession>
    <name>A0A1V0N4K8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="3 7 8">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="9" type="ORF">FAD_1198</name>
        <name evidence="10" type="ORF">HLB00_09825</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000437">
        <property type="protein sequence ID" value="NOL61115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142581.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4K8"/>
    <dbReference type="STRING" id="74969.FAD_1198"/>
    <dbReference type="GeneID" id="84217793"/>
    <dbReference type="KEGG" id="fai:FAD_1198"/>
    <dbReference type="OrthoDB" id="7610at2157"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09211">
        <property type="entry name" value="Lumazine_synthase_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="41"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL61115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="134" mass="14869" checksum="579AF4FDB20327C1" modified="2017-06-07" version="1">MKIGMVVAEFNYDITMMMVERAKDYADFLGIEYKILKVPGTFDIPLGIKKLLKIDDIDGIIAIGAVIKGETDHHRIIMENAARKITDLSLEYEKPVALGISGPGESRLQAEARIDMAKEALESCVKMVKSLNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4M9</accession>
    <name>A0A1V0N4M9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142559.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4M9"/>
    <dbReference type="STRING" id="74969.FAD_1182"/>
    <dbReference type="GeneID" id="31676680"/>
    <dbReference type="KEGG" id="fai:FAD_1182"/>
    <dbReference type="OrthoDB" id="57216at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09879">
        <property type="entry name" value="PIN_VapC_AF0591-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041120">
        <property type="entry name" value="PIN_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18477">
        <property type="entry name" value="PIN_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="118" mass="13383" checksum="F8329EB80F2BD1A9" modified="2017-06-07" version="1">MDKIILDTNILIYAIQNKIDLENGIMSITPRMEPLIPACVLAELRGLATTKWYAKAALKYSERFKNIESRGEGDFCIMVVAKSLNAAVLTNDRRFRKILKNKGIPCVTMGNQNNLQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4N2</accession>
    <name>A0A1V0N4N2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142568.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4N2"/>
    <dbReference type="STRING" id="74969.FAD_1190"/>
    <dbReference type="GeneID" id="31676688"/>
    <dbReference type="KEGG" id="fai:FAD_1190"/>
    <dbReference type="OrthoDB" id="56287at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="242" mass="27513" checksum="98A37671744D728F" modified="2017-06-07" version="1">MEEYEQNIKNGDAFVKKEKFMDAIREYTKAYDAISEDDIKAEICYKLSQCYSSLDHKSTENPLKYAEESLELHHKLGDNELEVMDLINIGYIYLDSGKREDGISYFNKAIEAADAIKDVTLFALSNNAKAEALSSLKSKQAEAMKIYDNVLELTEKSEDWENYFEALYGKISILRDADINAAFDAGKAGLDKIDTVMNTIKTKKDKKEFKDSVSYLYDSVSDIAMELENIDEAMKIASRSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Q3</accession>
    <name>A0A1V0N4Q3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bacterial bifunctional deaminase-reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142575.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Q3"/>
    <dbReference type="STRING" id="74969.FAD_1195"/>
    <dbReference type="GeneID" id="31676693"/>
    <dbReference type="KEGG" id="fai:FAD_1195"/>
    <dbReference type="OrthoDB" id="10178at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="189" mass="21578" checksum="C906EC407118D210" modified="2017-06-07" version="1">MIPYIIINVAMSINGKISAINGRYRISNDIDINRVMEIRKNVDGVLLGANSVKVDNPVLNYAKNRIILDEKLRLNDNYNVFDGKIKSYIFSRNNKKIKNAEIIILDDLSITSILKKLYDMGIKSILVEGGSNVINQFIDKKIFDEFYIFINPGLILDGIPLFKEEMKLNYKISMEGDGLLLNIKDINNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Q5</accession>
    <name>A0A1V0N4Q5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="11">KARI</shortName>
            <ecNumber evidence="11">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="11">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 16" type="primary">ilvC</name>
        <name evidence="15" type="ORF">FAD_1252</name>
        <name evidence="16" type="ORF">HLB00_03010</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Berkeley</strain>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.383"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.383"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000097">
        <property type="protein sequence ID" value="NOL59805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142674.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Q5"/>
    <dbReference type="STRING" id="74969.FAD_1252"/>
    <dbReference type="GeneID" id="84217847"/>
    <dbReference type="KEGG" id="fai:FAD_1252"/>
    <dbReference type="OrthoDB" id="6064at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000023">
        <property type="entry name" value="Ketol-acid reductoisomerase (NADP(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004017">
        <property type="entry name" value="PRK05479.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        <ligand>
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        </location>
        <ligand>
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        <source>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000546917"/>
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    </evidence>
    <sequence length="336" mass="37141" checksum="3A5D4FC2F892C82F" modified="2017-06-07" version="1">MSKVLGKVYTENDADLKYVKDKNIAVLGYGSQGRAWVLNLLDSGLNVKLGLEREGNSWKKAQEDGVKPMKTEDALKGADIVIFLVPDMVQRKIYAEKVKPVLKPGMDLVFAHGFNIHYKLIQPPENVDVYMAAPKAPGPSVREFFVKGGGVPVLVGVNQDYSGQALQKALAIAKGLGATKAGVLETTFKEETETDLMGEQLDLVGGLTAMLRATFHTIVDLGYRPEMAYFEAINEMKLITDQIYEKGLSGMLRAVSDTAKYGGLTVGTYVINDDVKKRMKEKAERIKSGKFADEWIEEYDEGSKNLASLMDDLDNSLEEQVGRELREIVLRGQPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4S2</accession>
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                <person name="Tatusov R.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="112" mass="12349" checksum="8CB2E7B5CAC2AF17" modified="2017-06-07" version="1">MDTEKKLEEVNRIMKEAGKDNSAFAGSFMNFMGATMGKGALDTKTKEFLALALGIAARCEWCISYHVNEAIKAGATRKELMEVGYVTVLMYGSQALMEMNSLVDAINKLEKQ</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="NOL60401.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="163" mass="17640" checksum="A4BBBFC47276D08B" modified="2017-06-07" version="1">MYKYNIGVIGGSFADKKYCNIAYEVGKKLAENNCAVFCGGKEGIMECVSHGVHDSNGMVVGILPGENRMEGNRYLSLAIPTGIGYMRNFLIIRASDAIIAIEGYSGTTSEAAFAITEGKTVVSIGDLQIKTKNTDGKLVHENNPEKAVEIAIQEAKNFVEKFH</sequence>
</entry>
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    <accession>A0A1V0N4S5</accession>
    <name>A0A1V0N4S5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">HLB00_06065</name>
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    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
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    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000206">
        <property type="protein sequence ID" value="NOL60397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841360.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4S5"/>
    <dbReference type="GeneID" id="16024464"/>
    <dbReference type="KEGG" id="fai:FAD_1236"/>
    <dbReference type="OrthoDB" id="56732at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="114" mass="13727" checksum="85AB67DE583B21FA" modified="2017-06-07" version="1">MMSVSPRKGMFIPKRATFVRKRKHSSRERFEPGYLTKEKQKMKAEKDNITNLRKALNKCGARMDCARKAIKRSRICRHNFEEIESGYHKVIRVYLRNGGYIHLENDRWIYHKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4S9</accession>
    <name>A0A1V0N4S9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Nucleotide sugar epimerase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1235</name>
        <name evidence="4" type="ORF">HLB00_06060</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000206">
        <property type="protein sequence ID" value="NOL60396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142649.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4S9"/>
    <dbReference type="STRING" id="74969.FAD_1235"/>
    <dbReference type="GeneID" id="84217831"/>
    <dbReference type="KEGG" id="fai:FAD_1235"/>
    <dbReference type="OrthoDB" id="4907at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="306" mass="35161" checksum="BB4CC6BC64EF367A" modified="2017-06-07" version="1">MSIKNKEILVTGGAGFIGSNLVNTLSKDNHVYALDDLQTGSMHNLKDSMDRIEFIKDRVKNINDYEINPDYIFHIGIYSSSPMYKNNPHLMANAIDDLITVLEYAKKNKSKIVYASTSSIYNGIEEQKEDVIPKVSDYYTEARIAMERIANLYCNLYGMDVSGMRFFSVYGYNERSKKIYANLVSQFLWAMHDNIAPVLYGDGEQKRDFVFVEDLVKALMLAAENNKKFNVYNVGTGKNYTLNELVKILNKHLGKDIKPEYIENPMKDTYVYYTLADIKKTEQKIGFKASISLDEGIDKLIKYYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4T0</accession>
    <name>A0A1V0N4T0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretory pathway DNA translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">virB</name>
        <name evidence="3" type="ORF">FAD_1265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4T0"/>
    <dbReference type="STRING" id="74969.FAD_1265"/>
    <dbReference type="KEGG" id="fai:FAD_1265"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051162">
        <property type="entry name" value="T4SS_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30121:SF6">
        <property type="entry name" value="SLR6007 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30121">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJGR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase HerA central" evidence="2">
        <location>
            <begin position="404"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="680" mass="76889" checksum="D476172E28CD1EEA" modified="2017-06-07" version="1">MVVYIKIPSNVYNFKSYIYGMPVEKFVIILSGVSMAAILFTISLPVTISAVAIYFGFMAYIKFDFSNIYKLRKLYFHGVAGHNIKFVRNGFLFCILGQDIFSAVEIENRELYTDSQKPNHIRAIMNVIDNLDCSANIITKTKVYNGKNYYRTFVILKTHGSAIETSMDLLKRNISAIVSNTALHGKAVDDENTIKSIFPANVNPELKYIGAGGFYMAYFDLLDTDYSQDFFYQTLIEKMGFTVEINMEINRIKNHEMQVKRLLASRKAEIVYTKTGHYAGLIKKQISALEYMSGKEKLYNASVRFSVISEHPAILRSNAETFKKTMESAGFRLKTFNYFNRNSFNPLELQGQGIKYMLDSASISELFPCSFTPIPDRAAEPLGINAITGKPFYFQPFMGNSYNIAITGETGSGKSYFAKKLLDQNRNAKVYVIDPLGEYSYGHVIDLSLGDYVDFMIETPEMANIISTAIAKLTGIGENNITGILTGLMSKSGVATFNELISEIRLGYSGNKSTQGAVYSMPFKTPVKLEGNFTVFRFGHKNAEIRDAFFDLVFSYIISTVEKEEGEKIVVMDESHLFLRNSREAEIIDMLARNSRHFRTSLITVTQNINDYYMNNYSESILMNSINYFIFRQHGKIKSSMFLGYEIDPSGLAGGSYSTYSECFYSTGSLIRKVKISEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4T4</accession>
    <name>A0A1V0N4T4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142664.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4T4"/>
    <dbReference type="STRING" id="74969.FAD_1246"/>
    <dbReference type="GeneID" id="31676744"/>
    <dbReference type="KEGG" id="fai:FAD_1246"/>
    <dbReference type="OrthoDB" id="25212at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005033">
        <property type="entry name" value="PRK06445.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF140">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE (ACETOACETYL-COA THIOLASE) (ACAB-5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="6">
        <location>
            <begin position="270"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="393" mass="42637" checksum="407A90A6C4311CAA" modified="2017-06-07" version="1">MKDVYIAYYKRTPFSRAKPDNPSKDVYNGVSMDVLLSKLIKDSLSTGINPEEIGDVITGCAIQAGENWTYGGRHQTLLSELPVSVPSMAIDRACSSSLNATAIGAMEIQTENSDIVLAGGMEHMTHVPLYNDPYVKYNTELMEKPEYKKYDMDVTYHVGLTAEKLAAINNISREDMDKFSFESQKLTGHAIEEGFYKDEILPVTVTHDGSVKTINADQTPRPESTLEQMGQLKPAFKENGRVTAGNSPPLSSGASLLMLMSGEKIKEYGLKPLARVIDYAAAGVDPTIMGHGPVPATNKLLKKNKLSPDNIDYWEINEAFAVVALNAIKHLNLDRNRVNIHGGSIAIGHPLGATGARIAGTLARTLQEKKGNLGVATLCVGGGQGYSLLIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4T6</accession>
    <name>A0A1V0N4T6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142749.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4T6"/>
    <dbReference type="STRING" id="74969.FAD_1280"/>
    <dbReference type="GeneID" id="84217875"/>
    <dbReference type="KEGG" id="fai:FAD_1280"/>
    <dbReference type="OrthoDB" id="57078at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator PadR N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="165" mass="19226" checksum="B39F8BBBAFD4F634" modified="2017-06-07" version="1">MNDYSLRILYILNLEDMTGYGLSRKLYNSATGKNISNGALIPVLNRLLSDNFIDFSVRNGKKYYHLTEKGKKFVGNVLDLNEEVRDQAIFDAIDREFPYINVFTDVEDYTLLKNIIKDIGHPIIEIIRQAFYLGKKNDQEGIELIKTMMDELLERAKERNLRNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4W9</accession>
    <name>A0A1V0N4W9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795583.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4W9"/>
    <dbReference type="GeneID" id="60420013"/>
    <dbReference type="KEGG" id="fai:FAD_1306"/>
    <dbReference type="OrthoDB" id="375066at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="54" mass="6396" checksum="D8E351AE8F236044" modified="2017-06-07" version="1">MISLKFKEMFYVDYSLAYAIIKQYGITDKDKEKIEKMNMDPGVRKAIYEILKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Y2</accession>
    <name>A0A1V0N4Y2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1329</name>
        <name evidence="2" type="ORF">HLB00_05605</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000188">
        <property type="protein sequence ID" value="NOL60308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886425.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Y2"/>
    <dbReference type="STRING" id="74969.FAD_1329"/>
    <dbReference type="GeneID" id="16024551"/>
    <dbReference type="GeneID" id="31676821"/>
    <dbReference type="KEGG" id="fai:FAD_1329"/>
    <dbReference type="OrthoDB" id="40443at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="91" mass="10587" checksum="57000F3DF440A244" modified="2017-06-07" version="1">MTEVIVVHKWKDEQKDQVMKFATTIMDMAKSKKLPAGLKLEELFLADKENQAVCRWDVDTLDHLMETAKSMKPTWDIQATEVTQKFKKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Z4</accession>
    <name>A0A1V0N4Z4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dpo4</name>
        <name evidence="3" type="ORF">FAD_1298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142779.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Z4"/>
    <dbReference type="STRING" id="74969.FAD_1298"/>
    <dbReference type="GeneID" id="31676796"/>
    <dbReference type="KEGG" id="fai:FAD_1298"/>
    <dbReference type="OrthoDB" id="372207at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002292">
        <property type="entry name" value="PRK01216.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="350" mass="39003" checksum="7C222A47BB355F27" modified="2017-06-07" version="1">MPFIIFIDFDYFYAQVEEIMDPSIKDKPVVVCVYSGRTENSGAVATSNYIARSIGIKSGMPLPQAMNIGKDKAVFIPIRKDFYKEFSDRVMNTISTYSDKMEIASIDEAYLDVTGECTTFQDAVKLGEEIKEEIFKEYGMKVSAGISINKAIAKILGDMAKPDGLKYIDESMVEEFLNTLEVKKIPGIGSILSKKLNDAGIKYLKDILGANRQAMIEILGNARYNYLVEIAENRYNSPVEERIRKNYGRYITLPENTRDTNIIMPLLRKAVDSAFSKAPGLPGEISAIGIMEDLNIVSRSYTGGRISLESAYGIATGLMGKILEADSRKLRRIGVRIGKMSSNESLDNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N503</accession>
    <name>A0A1V0N503_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="9" type="ORF">FAD_1301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886405.1">
        <property type="nucleotide sequence ID" value="NZ_DAIEUE010000037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N503"/>
    <dbReference type="STRING" id="74969.FAD_1301"/>
    <dbReference type="KEGG" id="fai:FAD_1301"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="8">
        <location>
            <begin position="30"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="283" mass="31278" checksum="E401C0D16861A176" modified="2017-06-07" version="1">MMKSKCDFGDFDKLVGGHVSIAGSIGLSPERAAAFGFNTFQIFVKSNLQWKYKPVTEEEVENFRDGVKKFHMAKPVVHATYLLNLGSENRELVEKSMDDIKYEIEVCNRIGVDRLVLHPGSNSNREIALNSIMELLNSLETGNVTMLIENSSGKGNTVPATSEEMGKMLDLSKNKIGICLDTCHFFAGGYDLKNGYKESIDSLRSNGITGHIGALHINDSMFDIGSKKDRHENIGNGYIGDAGFSNIINDRTFNNIPMIMETPGGDEHYSGNMEKLKSLLVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N534</accession>
    <name>A0A1V0N534_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gtrA</name>
        <name evidence="8" type="ORF">FAD_1343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142824.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N534"/>
    <dbReference type="STRING" id="74969.FAD_1343"/>
    <dbReference type="GeneID" id="31676835"/>
    <dbReference type="KEGG" id="fai:FAD_1343"/>
    <dbReference type="OrthoDB" id="56015at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051401">
        <property type="entry name" value="GtrA_CellWall_Glycosyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA_DPMS_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38459">
        <property type="entry name" value="PROPHAGE BACTOPRENOL-LINKED GLUCOSE TRANSLOCASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38459:SF1">
        <property type="entry name" value="PROPHAGE BACTOPRENOL-LINKED GLUCOSE TRANSLOCASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA_DPMS_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA/DPMS transmembrane" evidence="7">
        <location>
            <begin position="147"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="258" mass="29932" checksum="B34648B7AF9631ED" modified="2017-06-07" version="1">MIQKYYRGKPSYGDDFDYILISRMTIKSDTFDGIFHDVYSNHYDLTLLFGKQGIIAFIYGLFIKLSLSVKKGKVLPFGTIYSRNAYEYLISKNIVPDMEKNMILGNTLLLKNRSFEYKIVNTRLRCRENIHFKDFLDLTIRRGNMFRYIIVGITGVIVNEGVLLLLHGKLGSELSIIPAIEISIIYNFILNNKYTFKGRGHFYMRLAKYNLFNLIGFAANLGVYYTAVYYRTDIYVADFLGILVAFIITYTTATMIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N575</accession>
    <name>A0A1V0N575_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside-triphosphatase FAD_1425</fullName>
            <shortName evidence="4">NTPase</shortName>
            <ecNumber evidence="4">3.6.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleoside triphosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the THEP1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886532.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N575"/>
    <dbReference type="STRING" id="74969.FAD_1425"/>
    <dbReference type="GeneID" id="16024658"/>
    <dbReference type="KEGG" id="fai:FAD_1425"/>
    <dbReference type="OrthoDB" id="52698at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00796">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010248">
        <property type="entry name" value="PRK13695.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146:SF1">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="181" mass="20356" checksum="6455701476150507" modified="2017-06-07" version="1">MGIKVGITGPIGSIKTDALNKIMEMLQNNGKVIEGTLVSEKIEHGRVVAYYITDILTKRRVEFARIDLISRVKVDKLGVDTKLLEGLLVPSLQKSREEADVIVLDELGKVENTTKQIKAEIEETMKSDKSIIVTLHKKSRNPVLQEFRGYESVRVFDITPINKNILPFKILKVLNGEEESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N584</accession>
    <name>A0A1V0N584_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951141.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N584"/>
    <dbReference type="STRING" id="74969.FAD_1435"/>
    <dbReference type="GeneID" id="31676927"/>
    <dbReference type="KEGG" id="fai:FAD_1435"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="279" mass="31901" checksum="DCDCAECC85C6B56E" modified="2017-06-07" version="1">MPDIKKHFKIFIAILIVIILISSFIVYDITRNNVTYNNNGEPIDVKYFSVGYTFPYITNNYTASSYYVNHNKLSYMNSTIIQPRVLPYGYGCICFGINIHLKNVNNKYIYVDIISQAEPSTFNPSLNNATEIHSSYISGVCHVKYRINGNNISIPSITIRNIDKYIHNNYYNISVSISLNNNFYNTFDISGIKETAIYGTVQNTSSLSIDKINTSLLIENINNSNYKTMHVINGYFYCFLKPDTEYKLYNSNLTYIYTIDASNLTAGHSFNFEIPSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5A5</accession>
    <name>A0A1V0N5A5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1439</name>
        <name evidence="2" type="ORF">HLB00_01305</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000038">
        <property type="protein sequence ID" value="NOL59474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142904.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5A5"/>
    <dbReference type="STRING" id="74969.FAD_1439"/>
    <dbReference type="GeneID" id="84218031"/>
    <dbReference type="KEGG" id="fai:FAD_1439"/>
    <dbReference type="OrthoDB" id="52988at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="194" mass="22381" checksum="F8B313C4802191C6" modified="2017-06-07" version="1">MIENFEDTKRYKLILNEINGEEKSITGIQKSLEEKGINMHRLVLTGYLNAMVELGILREREIKPARIFSFVGQNKQDIYSIIGSNMKKFDESNAGYNSLLVLHYLFERPIFTRELEKCNVVIPSKSIKYVDSRYRADYIKKLGEANIKISPSSTLIEPVDADKISITKLLNYIISNEYDIKKYTVVNTSQKTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5A7</accession>
    <name>A0A1V0N5A7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142898.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5A7"/>
    <dbReference type="STRING" id="74969.FAD_1433"/>
    <dbReference type="GeneID" id="84218025"/>
    <dbReference type="KEGG" id="fai:FAD_1433"/>
    <dbReference type="OrthoDB" id="56245at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="84" mass="9973" checksum="5981EB3FEADC2B4D" modified="2017-06-07" version="1">MSDYIHELRFMEEKNLTLEISYRLNYEDKACGSIRIFDGQIDPEKDNYELYMELLECGLTSEQVEERVKKMEDEINSGKLDLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5B0</accession>
    <name>A0A1V0N5B0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">GGGP synthase</shortName>
            <shortName evidence="9">GGGPS</shortName>
            <ecNumber evidence="9">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>sn-glycerol 1-phosphate + (2E,6E,10E)-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GGGP/HepGP synthase family. Group II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5B0"/>
    <dbReference type="STRING" id="74969.FAD_1427"/>
    <dbReference type="KEGG" id="fai:FAD_1427"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047294">
        <property type="term" value="F:phosphoglycerol geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02812">
        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010946">
        <property type="entry name" value="GGGP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01769">
        <property type="entry name" value="GGGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003198">
        <property type="entry name" value="PRK04169.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF22">
        <property type="entry name" value="GERANYLGERANYLGLYCERYL PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="259" mass="28504" checksum="038146A1E6985934" modified="2017-06-07" version="1">MIRITLTTLKLNKVEYVSVYKNIMEILKYKRVHMTLIDPAAQSPDRSVELAEKADKAGTDFFLIGGSTDIDSRLMDKTISGIKEKTEKQIIIFPGSRSMISRYADAIYYMMLMNSTNIDYIVGHQIGSASILKMMGIETIPMGYLIFEPGMTVGRVGNARLIGRDDENTALSYAFAAEFFGFKLLYLEAGSGAPEPVGCNVIRRIKESVKIPVIVGGGIRDYGKARSIIDAGADIIVTGTVIEKHSNPYMALKDIISAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5C6</accession>
    <name>A0A1V0N5C6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142916.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5C6"/>
    <dbReference type="STRING" id="74969.FAD_1453"/>
    <dbReference type="GeneID" id="31676946"/>
    <dbReference type="KEGG" id="fai:FAD_1453"/>
    <dbReference type="OrthoDB" id="36308at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="375" mass="41496" checksum="FA42A25EE1605F98" modified="2017-06-07" version="1">MEIEEYVKNILNDIKSGGIDAVSEYSKKFDGYGMPFKVPESEFAEAKELIPVYQKDIINRTYKRIYENHAIQYNNDKVRFSRGSIYGIRYTPIERIGMYIPGKKPLPSTVMMIGIPAKIAGVRDIVIVSAPESNGRVNPYTLYIAGLLGIHEVYRIGGVQAIGSMAYGIGMKKVDKIFGPGNSYVNEAKRQVYGFTGIDGLYGPSEVMVISDGTAKDEYILADLNSQLEHGITSKAWLLTTGKAISTAGNERIEVMVFENMDELISKANEIAPEHMEIQAKDPMGIFSRIKNAGAIYIGEYAPVPAGDYFLGVNHLLPTGGTSRFSSALTVDDFMKKTSFASVSREDFMADRELGLELAKIEGMPLHYKSMEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5C7</accession>
    <name>A0A1V0N5C7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter 1, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886564.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5C7"/>
    <dbReference type="STRING" id="74969.FAD_1459"/>
    <dbReference type="GeneID" id="16024689"/>
    <dbReference type="GeneID" id="31676952"/>
    <dbReference type="KEGG" id="fai:FAD_1459"/>
    <dbReference type="OrthoDB" id="50379at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42744">
        <property type="entry name" value="BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS INNER MEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42744:SF1">
        <property type="entry name" value="BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS INNER MEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="11"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="320"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="540" mass="61110" checksum="3DAB80099BC88E85" modified="2017-06-07" version="1">MDAIILIILAVLATAGRVIGLILLSILTGWFLAYASIKSKFFENIYIILIEVFESIPVITFFPVVLVIFITHVGGTLGVELAADFLVFTAVVWNIWMGEYQAFKTVPREMVEVVENSRFGLFSRLRYLYIPFSVPRITANLFPSVSNGFFYITVSEVFEVGVHTYQTFGIGSVLDTFVAGAQLFNIEMALLILGIVIVAIVIVLREFSKYAVGRYTLDTDAPVMKRGRLNLRETARVFAALSKNPLTRLARYYKYREGDKHEQTYEKKEKKQKRYKYIYASIGIIILIALLYGVVSLIISVKPSEWSILFNKTPFLLTGLGFDYVRVGSILLVSMVIAIFLGYYLAVNKRAEKYWIPIIQSLSAYPAPIYFPFLFILTEPFMLSLFGGFTNELYVLSLGFVSTFYYVFYSFWMGVKAMPSEYWEITKNLKLGYFKKMRKVIIPSTFPYLISGISSTINSAWGGLMIGEYWPNIYGTHSLSVHTGLMKTIDIATANGDLTLAAWGSLIFGIIVAIYSVLFTRKMMDLAQKKYVAEEGVYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5D0</accession>
    <name>A0A1V0N5D0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940563.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5D0"/>
    <dbReference type="GeneID" id="31676978"/>
    <dbReference type="KEGG" id="fai:FAD_1484"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517:SF2">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN MDTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="409" mass="46248" checksum="EB7B1A3D0F67567B" modified="2017-06-07" version="1">MDRRVFYLGLTRLIRASGRVSSFIFLPLIFVFIYHISFIETGIVLGVAILLMSAIQYYSGILTDRIGRRVFLILIPIPAGLLYISMYFTVLYRLPVMLLIGLFYSTIAINALQYPAIQASIADVTSLKQRLSGYTEIRVMANAGAAIGPILGAILSVYGFQYIFLMAGIATFIEIIILYFNVKETYFPSKIEYLTKNDIKLAYKDRFFILFIIIGIIMAFVLRQRGASLTLYAFDFEGLPILYLAYIYSLNGILVVLLQYPIFKLMNRETRPVLFRSVGMLFYFLGFIVLMFSKNIDYFLLSMGIMTVGEDFVAPTTQTIITSIAPNNMKGTYIGIYNLFISFGSFSGSIVGLYMLSYYESATATFWLLIAMSSLVVSVLYLAINNAFLKRMNLSIKKKISSYKKTSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5D3</accession>
    <name>A0A1V0N5D3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886568.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5D3"/>
    <dbReference type="STRING" id="74969.FAD_1463"/>
    <dbReference type="GeneID" id="16024693"/>
    <dbReference type="KEGG" id="fai:FAD_1463"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="151" mass="16802" checksum="34E32868C140457B" modified="2017-06-07" version="1">MANRIEQIMKFSDDLETLNKMFEQNENLFAYLGIKITKISKGYCELSLPYSEKITRAGNVLHGGIMMTAVDYAGGITTMTVNDGMDQVTQEVKVNFLAPMSEGPFRIEGKAIKAGRTAVIVEIKLFDSEGKLGIVALGTWYVIRDRIIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5L1</accession>
    <name>A0A1V0N5L1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit Rpo10</fullName>
            <ecNumber evidence="6">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpo10</name>
        <name evidence="6" type="synonym">rpoN</name>
        <name evidence="7" type="ORF">FAD_1595</name>
        <name evidence="8" type="ORF">HLB00_01550</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000041">
        <property type="protein sequence ID" value="NOL59521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886728.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5L1"/>
    <dbReference type="STRING" id="74969.FAD_1595"/>
    <dbReference type="GeneID" id="16024861"/>
    <dbReference type="GeneID" id="31677085"/>
    <dbReference type="KEGG" id="fai:FAD_1595"/>
    <dbReference type="OrthoDB" id="371754at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="73" mass="8315" checksum="580F5DB0414323A1" modified="2017-06-07" version="1">MIIPVRCFSCGKVIGSDYVRFVEESKKIRKDTGHDPTGKEKSEILDNLGVDRYCCRRMILSNADLLDEVISYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5N3</accession>
    <name>A0A1V0N5N3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvA</name>
        <name evidence="9" type="ORF">FAD_1556</name>
        <name evidence="10" type="ORF">HLB00_00960</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142951.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5N3"/>
    <dbReference type="STRING" id="74969.FAD_1556"/>
    <dbReference type="GeneID" id="31677047"/>
    <dbReference type="KEGG" id="fai:FAD_1556"/>
    <dbReference type="OrthoDB" id="9915at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="326"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="401" mass="43871" checksum="6A518F0F90F565D6" modified="2017-06-07" version="1">MLSYDRIVRAGNEIKGKIHRTPLFHSTTFSNMFSCDVYFKMENFQKTGSFKSRGAMEKFSTLTAEQKKNGVITASAGNHAQGVAFAASYYGVDAKIVMPETTPPAKVNAVQSYGGTVILKGNSYDEAHEYAVQVSVDEKREFIEAYNDEDVIAGQGTIGLEILEDVKPDIVIVPIGGGGLISGISFAIKSKNKDIKIIGVESEKANAMELSIKEGKIVPYTSNDTIADGIAVKYPGNITFELVKKYVDGVVTVSDENIAYALFKLLEREKVLVEPSGAAGLAALFENKIDVKGKKVVIVLSGGNVNFLLLSNIIYRALEMENKLLRLEFNLPDHPGIMEKIVNAISSSGANIYHAEVDNLNKDTPIGYQYLLFTINILDKSRIDELLGSLDKLGYKYRIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5R9</accession>
    <name>A0A1V0N5R9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Proteasome core protein PsmA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">psmA</name>
        <name evidence="8" type="ORF">FAD_1583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="4">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841472.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5R9"/>
    <dbReference type="STRING" id="74969.FAD_1583"/>
    <dbReference type="GeneID" id="16024849"/>
    <dbReference type="GeneID" id="84218176"/>
    <dbReference type="KEGG" id="fai:FAD_1583"/>
    <dbReference type="OrthoDB" id="9421at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03756">
        <property type="entry name" value="proteasome_alpha_archeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_A">
        <property type="entry name" value="Proteasome_A_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="234" mass="25594" checksum="C161F1B6495EA405" modified="2017-06-07" version="1">MQQGQMAYDRAITVFSPDGRLFQVEYAREAVKKGSTALGIKFKDGVLLLSEKKARSRLVEKNSLEKIQLVDDNVATVTSGLVADARVLIDFARVGAQQEKVTYGSLTNIENLVKKVADQMQQYTQFGGVRPYGVSIIFAGTDTIGPRLFDCDPAGTINEYKSVAIGAGKDAVTDYIEKEYKDDMSLEDTIKLGVAALKSALADASSMKEPEIASIKVGETFHVYTNEEVSKYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5U6</accession>
    <name>A0A1V0N5U6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-phosphosulfolactate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15597"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58738"/>
            <dbReference type="EC" id="3.1.3.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ComB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.71" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886752.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5U6"/>
    <dbReference type="GeneID" id="16024886"/>
    <dbReference type="GeneID" id="31677110"/>
    <dbReference type="KEGG" id="fai:FAD_1621"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050532">
        <property type="term" value="F:2-phosphosulfolactate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050545">
        <property type="term" value="F:sulfopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1560.10">
        <property type="entry name" value="ComB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005238">
        <property type="entry name" value="ComB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036702">
        <property type="entry name" value="ComB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37311">
        <property type="entry name" value="2-PHOSPHOSULFOLACTATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37311:SF1">
        <property type="entry name" value="2-PHOSPHOSULFOLACTATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04029">
        <property type="entry name" value="2-ph_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142823">
        <property type="entry name" value="ComB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="229" mass="25701" checksum="BB2ACC7F28854238" modified="2017-06-07" version="1">MIVNVIDGRREKNFDDSTKVLIDIFRATTTIPLMLYRNAKSIIPVRTITETRKMKAKNPDYLTSGERYGVRIPRFNYGNSPSVIMGEDLSGKTLLFTSTNGIKVLFKIREFPGDIYLSSFINFTATYNAIKDREKVSIIVSNRPDGISDEDYIYANMLKAKLEGEEVNVDDYCNQIRASHGAKRLKIMGAAADIESSLKVDIYHEPIIYSNGKIIPLTKLSGKSPSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5U9</accession>
    <name>A0A1V0N5U9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143002.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5U9"/>
    <dbReference type="STRING" id="74969.FAD_1659"/>
    <dbReference type="GeneID" id="31677148"/>
    <dbReference type="KEGG" id="fai:FAD_1659"/>
    <dbReference type="OrthoDB" id="55801at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="205" mass="24569" checksum="DDB4F923049095FC" modified="2017-06-07" version="1">MKAEVFKPGNIKKLKKDFDNIDECDKPVYYMVINLFESFPGKISAIKVYRGSDIDLKIRLGNTDYRYIKILKSKSGMFEIMRLPLDERKIGKYSLYDMIRNDVESGNELKRETRNEILKYIDFNRNRKKLLYILNDSENANYYIMKETTIKDIVVRDIEYMYTKNSSYRVYNGTIPVKFIGDYWSSYLKRRKKTEKDVWKSLITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5V7</accession>
    <name>A0A1V0N5V7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1640</name>
        <name evidence="5" type="ORF">HLB00_07225</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000264">
        <property type="protein sequence ID" value="NOL60619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142989.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5V7"/>
    <dbReference type="STRING" id="74969.FAD_1640"/>
    <dbReference type="GeneID" id="84218232"/>
    <dbReference type="KEGG" id="fai:FAD_1640"/>
    <dbReference type="OrthoDB" id="26084at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041800">
        <property type="entry name" value="Hsp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="83"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="179" mass="20636" checksum="F0F16486844D07D1" modified="2017-06-07" version="1">MNGRRDDDWDDIFNDMYDEFGFDMKKINREIARFWESIMKGEPNSKIMGPYVYGFSYKMGPDGKPVFQEFGNVPRNGIGPKAEPQGGFREPLTDINEDKENVYITYELPGVEKNDIDLVVNENNIELKVDKGSRKYYKNIEFDREVDINSVIAKFTNGVLDITIKKVNNKSTGRAVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5W7</accession>
    <name>A0A1V0N5W7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo11</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo11</name>
        <name evidence="4" type="synonym">rpoL</name>
        <name evidence="7" type="ORF">FAD_1650</name>
        <name evidence="8" type="ORF">HLB00_04415</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000151">
        <property type="protein sequence ID" value="NOL60078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886786.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5W7"/>
    <dbReference type="STRING" id="74969.FAD_1650"/>
    <dbReference type="GeneID" id="16024919"/>
    <dbReference type="KEGG" id="fai:FAD_1650"/>
    <dbReference type="OrthoDB" id="24205at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002241">
        <property type="entry name" value="PRK01146.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="104" mass="12172" checksum="124DD6A5E9E26C78" modified="2017-06-07" version="1">MDSQFNIISKDKDSIKVEMINYDNTVLRPLVEEILKDDKVVESHYYIKHPDIDNPEIYVKVSTGKPQAAIKRAIKRMNKIYESLDAELQKELEKFKASTEKNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N613</accession>
    <name>A0A1V0N613_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATPase RIL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886893.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N613"/>
    <dbReference type="STRING" id="74969.FAD_1751"/>
    <dbReference type="GeneID" id="16025026"/>
    <dbReference type="GeneID" id="31677242"/>
    <dbReference type="KEGG" id="fai:FAD_1751"/>
    <dbReference type="OrthoDB" id="30658at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001546">
        <property type="entry name" value="RNase L inhibitor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="66"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="337"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="590" mass="66226" checksum="6800DDA45B75D643" modified="2017-06-07" version="1">MHIAILDRERCHPKKCNHECRYYCPPVRSGAKTIEFPGQSDDFPVITESLCIGCGICVNRCPFGAIKIVSVPDELNKDIVHQYGIDSFRLYSLPELGTGRVNAILGQNALGKTTTMNILSGVLIPNFGNISKKNDKDYVIERFSKSIMGQYFRDLYNGTKKAVLKNQYVDLIPRVASGTVRDIMKDNDHGNMDIIVDDLSMKTFLGRDVKELSGGELQKLAIGITLMKDADIYLFDEASSYLDINERIRVSDIIRKLSQSKIVMVVEHDLAILDKMADQVNLVYGSPGAYGVITKEKSTNKAINAFLSGYLREENVRVRPTSIDFTVKSSKRTSVTTKVTSWTAMEKSYGSFNLNIGEGYINREEIIGVLGQNALGKTTFVKILSGVIKPDSGSVENELKIAYKPQYISTDYEGTVYELLSTALKEKMEDVFIKNEILSPMNVSELYDNYIGDLSGGELQRTSIALTLATDADLYLIDEPSAHLDSSYRMNVARIIRRVIENNKKSAIVVDHDIYLIDLISDALIVFKGEQGVYGNSRGPMEMRDGMNMFLKDLGITFRRDETTRRPRINKLNSALDRQQKASGEYYYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N638</accession>
    <name>A0A1V0N638_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="4">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dtdA</name>
        <name evidence="5" type="ORF">FAD_1715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DtdA deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951152.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N638"/>
    <dbReference type="STRING" id="74969.FAD_1715"/>
    <dbReference type="GeneID" id="31677206"/>
    <dbReference type="KEGG" id="fai:FAD_1715"/>
    <dbReference type="OrthoDB" id="9863at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10700">
        <property type="entry name" value="AF0625-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.50">
        <property type="entry name" value="AF0625-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00562">
        <property type="entry name" value="Deacylase_DtdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018033">
        <property type="entry name" value="Deacylase_DtdA_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007508">
        <property type="entry name" value="DtdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003072">
        <property type="entry name" value="PRK03995.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667:SF1">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04414">
        <property type="entry name" value="tRNA_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016210">
        <property type="entry name" value="UCP016210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142535">
        <property type="entry name" value="AF0625-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="257" mass="29076" checksum="056624469BBCABA7" modified="2017-06-07" version="1">MILLIASRKDGASMEMASRLLELFKFDKLDANRYTYKNYELKFIDNLHIYQNMEDLEEEVEKVVFLSKHSSKADIKSLTVHPIGNFRKAELGGLDNVIVPSDPLGMSASLRYIKNNYSGDHFEITFEATHHGPYMEKPAYFIEIGTTENEWKQEGIADLMARAIMEGVEKDYGNYVGVGGGHYAPKLSSYFFSNDINIGHIIPKYVHEIISEDEIENAVLKTMNCKGFLMDAHGTKGRVKDMIAGIADKHSLEVLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N640</accession>
    <name>A0A1V0N640_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143040.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N640"/>
    <dbReference type="STRING" id="74969.FAD_1706"/>
    <dbReference type="GeneID" id="84218326"/>
    <dbReference type="KEGG" id="fai:FAD_1706"/>
    <dbReference type="OrthoDB" id="21421at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005011">
        <property type="entry name" value="PRK06407.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="296" mass="33289" checksum="B490CDC2AFC1C142" modified="2017-06-07" version="1">MITYIDDNDVKNNLPVKECVDELKEAFISYGKGESDSSPRDRIYGKDFVFSTMPALYEKRGIAGLKTYMYGKSGYRFFVILFSTENPGKLFAMDANVLGQIRTGAISAMVTTMLVKKKRINYTIIGSGFQSESQLNSISEYYELENAHVYSRNFEHAKKFAEKSRIKVEPVKDLSCLKESDIIASATDTEEPIFNYSMLPENYHINLIGSNVLGSREADKDVFENSGLVIEENSKQSAMESSEISDIKDRSKITTLGEFMLNPDKYRNSKSVFKCLGIGLEDLAAGYIVLKNMSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N653</accession>
    <name>A0A1V0N653_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps2</name>
        <name evidence="6" type="ORF">FAD_1774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N653"/>
    <dbReference type="STRING" id="74969.FAD_1774"/>
    <dbReference type="KEGG" id="fai:FAD_1774"/>
    <dbReference type="OrthoDB" id="371797at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000030">
        <property type="entry name" value="30S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_A">
        <property type="entry name" value="Ribosomal_uS2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023454">
        <property type="entry name" value="Ribosomal_uS2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="200" mass="22786" checksum="D5ACC6C7F50D8C5E" modified="2017-06-07" version="1">MMEEQLLIPEEEYQKSGIHIGTQVKSKDMDRYIFKIRNDGLYILDIKKTNHALIEAGKMLARYQPEQILVVAQRQYAFKPVAKFSEIVGSSSIIGRFIPGTLTNPNLKSYYNAKVILITDPLADTQAMKEAIRIGIPVISLCDANNKTDFVDLIIPTNNKGRMSLAVIYWLLSREILKNRGDIKSYDEMKAKVDDFEVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N678</accession>
    <name>A0A1V0N678_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">A-type ATP synthase subunit A</fullName>
            <ecNumber evidence="12">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ntpA</name>
        <name evidence="12" type="synonym">atpA</name>
        <name evidence="17" type="ORF">FAD_1821</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane. The A chain is the catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Has multiple subunits with at least A(3), B(3), C, D, E, F, H, I and proteolipid K(x).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143108.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N678"/>
    <dbReference type="STRING" id="74969.FAD_1821"/>
    <dbReference type="GeneID" id="31677311"/>
    <dbReference type="KEGG" id="fai:FAD_1821"/>
    <dbReference type="OrthoDB" id="115235at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="14">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="15">
        <location>
            <begin position="109"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="211"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="16">
        <location>
            <begin position="442"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="231"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ARD85660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="589" mass="65631" checksum="38057A88F7A807C4" modified="2017-06-07" version="1">MENKGSIYSISGPVVIATDLDGKMFDVVRVGEMGLVGEVIKIVGDKFTIQVYEDTSGLKPGEPVYSTGKPLSVELGPGLLKSIYDGIQRPLDIIQSETGDFIVRGATAPPLDEKKEWDFVPLLKEGDEVEQGYILGTVQETNIITHKIMVPYGIRGIIKSISKGKFKVSDTVCIIDTGTSKYDIKLKQIWPVRQARKVFLKFAPEIPLITGQRVIDSFFPVAKGGTVAVPGPFGSGKTVIQHQLSKWSDADITVYVGCGERGNEMTEILSTFPELQDPKSGKPLMEKTILIANTSNMPVAAREASIYTGVTIAEYYRDMGYDVALMADSTSRWAEALREISGRLEEMPGEEGYPAYLGRRISEFYERSGNAQIIAQDERTGSITLIGAVSPPGGDLSDPVVQNTLRVTRAFWALDASLASRRHFPSINWLNSYSLYLDSLSGWFKSNVNPEWPQMHSLMMGILQKESELQEIVQLVGYDSLPENQKNVLDIAKIIREDFLQQNAFDDTDTYCSIKKQYEMLTIIKTLNEMQEKSIASGLKLTQTATLPVRMKISRMKEIPENDFEKFYNDVIKEINNEYDNIMEGVESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N686</accession>
    <name>A0A1V0N686_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable octanoyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lipB</name>
        <name evidence="6" type="ORF">FAD_1760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143073.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N686"/>
    <dbReference type="STRING" id="74969.FAD_1760"/>
    <dbReference type="GeneID" id="31677251"/>
    <dbReference type="KEGG" id="fai:FAD_1760"/>
    <dbReference type="OrthoDB" id="56985at2157"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="35"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="219" mass="24724" checksum="7C1295131F1E8B00" modified="2017-06-07" version="1">MQQKGVTDYWTDLGKVSYSDALDIQYNLVARRKENKIPDTILFLDHYNVYTIGRKSDPENYKNVDVIKTDRGGDVTYHGEGQLITYFIFDVRINGKKEVRKLLESIEESYIAMLKTYGYNAMLYGEPGIWIDKGGIKNKVASLGMAVDDYVSYHGMALNISASVLDGFGLINPCGMNSSVISYVDIPREDAIKGLLKEFSGHFGEFSYIDKENLIRTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6B0</accession>
    <name>A0A1V0N6B0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nitrite reductase/sulfite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886934.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6B0"/>
    <dbReference type="GeneID" id="16025065"/>
    <dbReference type="GeneID" id="31677276"/>
    <dbReference type="KEGG" id="fai:FAD_1786"/>
    <dbReference type="OrthoDB" id="56446at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="113" mass="13169" checksum="E0FCD16F5E0504A1" modified="2017-06-07" version="1">MKKDVNEYLNNIINSAPSEEMYFEAIRDIFKDLVKEYIRKKINEDEDLKKQISEVIEEFMEAKIKEYDSLAKMAKVTAKIGLVSAPNGIKQEALNDFMNTFKKEIEEIIKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6C0</accession>
    <name>A0A1V0N6C0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arsenite efflux pump permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arsB</name>
        <name evidence="7" type="ORF">FAD_1796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143097.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6C0"/>
    <dbReference type="STRING" id="74969.FAD_1796"/>
    <dbReference type="GeneID" id="31677286"/>
    <dbReference type="KEGG" id="fai:FAD_1796"/>
    <dbReference type="OrthoDB" id="19068at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01118">
        <property type="entry name" value="ArsB_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00935">
        <property type="entry name" value="2a45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011980">
        <property type="entry name" value="PRK15445.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="429" mass="47605" checksum="ED8A08A9ACB23285" modified="2017-06-07" version="1">MTLLFYLALLIFAITLVLVLKKPKNIGIGYSALAGAVVTIILGISTLHDIITVWDIVWNATFTFISVIIISLILDEAGFFEFIAYKMALYSRGNGKKLFMLIILLGSGISAIFANDGTALILTPIVYAILYRSNFSKNRILPFIMATGFIADTASIPFIVSNLVNLVTAGYFHITFSRYTEIMLIPDIVSVVSSLFVLYIYYRKNIRDDFHTDPAVKPSSFIKDRRIFLMAFPATVLLMVLYFLSGFIGVPISFIAMPFALIFYIVARLGGRIDANHVIKIAPWQVVLFSLGMYIIVFGVSSNGLDSIYIVILNYFSSLPGPFPIITTGFFFAMNAAFMNNMPSVMIGDIAISGIAHPGLLMYANIIGNDIGPKFTPIGSLATLLWLYTLERKNSIKISFSYYMKTGFILAVPVLFFTLLSLYIMSLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6E1</accession>
    <name>A0A1V0N6E1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887000.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6E1"/>
    <dbReference type="STRING" id="74969.FAD_1851"/>
    <dbReference type="GeneID" id="16025134"/>
    <dbReference type="KEGG" id="fai:FAD_1851"/>
    <dbReference type="OrthoDB" id="56543at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22437" checksum="813C6832E450F6A1" modified="2017-06-07" version="1">MSRTGRGNVETMVRDYIKKNPELIISMRMGILNVSKLSRKISQEETGYNIISIRSALNKIFMENSSADTVHIDRLLSESKITLQDKIMVITVDRKIDNLNFLSATYLTDSIVYIVDETKNKKLDLPKNAVIERNVSSLHIFSSMEIVKTPGFVMKINERLFSYEINVLQLISCSNETIIIVNRKDAIRAYEALMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6J1</accession>
    <name>A0A1V0N6J1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="10">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">lysS</name>
        <name evidence="12" type="ORF">FAD_1864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143128.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6J1"/>
    <dbReference type="STRING" id="74969.FAD_1864"/>
    <dbReference type="GeneID" id="31677354"/>
    <dbReference type="KEGG" id="fai:FAD_1864"/>
    <dbReference type="OrthoDB" id="6838at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940:SF1">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="11">
        <location>
            <begin position="415"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="23"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="507" mass="58060" checksum="B67E77A17B566388" modified="2017-06-07" version="1">MYWADALVENLNGTQLISTGISPSGPIHVGNMREILTGDILYKASLDKKLESRFIYLCDDLDPLRKVYPFLDGSYSQYVGMPLSYIPAPEGDGKYSDYFLKPFLETLKKINVNVEVISTTGLYREGKLAEAIDIAMNHREEIAKIMHDVAGYDIGPEWYPYEPRCSKCGKINSSTVTRYENPYAYYKCKACGNEDKADIRKDDGKMPWRVEWPAKWYALGVTIEPFGKDHAASGGSYDTGKEIAAKIFKISPPVPLMYERILLKGVGVMHSSTGVAITASEVTTFAPPEILRFLIARNDPGRHIDFDPGMGLLNLIDDYEKMERAYFGLDESNNENFKRIYEMSRIKILDAPEKINFRHIVTLIQIYRDDNSFFSALKRSGYDKDQIDDYLKNEIVIAKYWLSKYAPENIKFSLTDKQFLLTDDQRSILQEFLDKLASVEWTSDSIHTVIYDIIGDRKLTPKDVFTLFYRVFIDKDKGPRLGYFLSSMDKNYVVDRIKSLIQNDSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1A5</accession>
    <name>A0A1V0N1A5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141230.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1A5"/>
    <dbReference type="STRING" id="74969.FAD_0004"/>
    <dbReference type="GeneID" id="84218495"/>
    <dbReference type="KEGG" id="fai:FAD_0004"/>
    <dbReference type="OrthoDB" id="56510at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD83940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="116" mass="13260" checksum="B37FC6271ACAB529" modified="2017-06-07" version="1">MGEFSIRSGSFDILREITHYMPTKLLISDGIMLEKNILNFNVKIQRIMTPYQLNRIVIESGIEKYLILISSFVLDSWGLSVIGEINYVMEQSVYNGSAVIFDIVGSKTVNEEFMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1D4</accession>
    <name>A0A1V0N1D4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0027</name>
        <name evidence="8" type="ORF">HLB00_07550</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000279">
        <property type="protein sequence ID" value="NOL60682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_171481848.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1D4"/>
    <dbReference type="STRING" id="74969.FAD_0027"/>
    <dbReference type="GeneID" id="84218517"/>
    <dbReference type="KEGG" id="fai:FAD_0027"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="340" mass="38692" checksum="E6744C3B81CC9456" modified="2017-06-07" version="1">MAKTNSQVEVATFYQRIFAYLIDLTLLICITSFILYPLHKQFELFDLVEVYSYGTKGITTSYADKLLISSMIFVIVSFVYFFFEIYGNLSLGNRLVHGKIVLLKTDNSYISKTLIRTAIKAFPITNIVDSLSLLRKRERPQKFTEQALHIFYIDNAKKKHLYDYILISAILYYLPLFTISIITLMIGKTYFSGGSGSIAPYHNPTFNQLNNILIGNNTSYDLQLELGGLFLLIPTIFVLYTSSLLEGSVMGMALLGNKYTFVDKVLPQFFPETFAYVLGIAFAMCVVTIVTSFIENYTKGISYKEFQNILKAETSMFVFYFATSMFLIFIAANIESYVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1F4</accession>
    <name>A0A1V0N1F4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="11">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">xth</name>
        <name evidence="10" type="ORF">FAD_0033</name>
        <name evidence="11" type="ORF">HLB00_06520</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000231">
        <property type="protein sequence ID" value="NOL60486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887044.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1F4"/>
    <dbReference type="STRING" id="74969.FAD_0033"/>
    <dbReference type="GeneID" id="16025179"/>
    <dbReference type="KEGG" id="fai:FAD_0033"/>
    <dbReference type="OrthoDB" id="146626at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09073">
        <property type="entry name" value="ExoIII_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00195">
        <property type="entry name" value="exoDNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="8">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD83968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL60486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="252" mass="29163" checksum="6AB23D3982F927AF" modified="2017-06-07" version="1">MKILSWNVNGIRAAVKNGIIKTLENENPDIILLQEAKADKMDIPEELHHTGYKIYVNPADKKGYSGTMAMAKQEPLSYTTGTGENNKDVEGRIQTLEYDNFYLINSYFPNSQHGLTRLDYKIQFNREILEYMDKLKAKKPVIITGDFNVAHEEIDIARPKGNEKNAGFTIEERDSMTEILSHGYVDTYRYFHKEPGHYSWWSYRFNAREKNIGWRIDYFLVSDNFIGKVEDSLILENVTGSDHAPLELILKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1H3</accession>
    <name>A0A1V0N1H3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0067</name>
        <name evidence="7" type="ORF">HLB00_07370</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141280.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1H3"/>
    <dbReference type="STRING" id="74969.FAD_0067"/>
    <dbReference type="GeneID" id="31675579"/>
    <dbReference type="KEGG" id="fai:FAD_0067"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019546">
        <property type="term" value="P:L-arginine deiminase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="CARBAMATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409:SF1">
        <property type="entry name" value="CARBAMATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="5">
        <location>
            <begin position="101"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="253" mass="28174" checksum="7F5DB0DF86555E21" modified="2017-06-07" version="1">MKRIVMAIGNNYPDYNEKCGSPGLIDDIFAKSGKLISENEIVMTCGDSYPENADTFYPVNIINAYDRVKYKYGYSKEIIAVFTRVEIRKISNPSVQTGDNYTESGIPENGKTEEFLEPIDIPEKSAIMTLMSDGYLPIIIGAGFPVVRELQYYNNCHGMVNNYSSSSLLGTLIEADELIIISGHRDEFKGIVNSQELLNNITFDALMDIYKRGKFKDNIAGKKVKAMLDFISKGGKKAILMSTGMDNVITLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1L7</accession>
    <name>A0A1V0N1L7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1L7"/>
    <dbReference type="STRING" id="74969.FAD_0051"/>
    <dbReference type="KEGG" id="fai:FAD_0051"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004720">
        <property type="entry name" value="PRK06064.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF6">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="3">
        <location>
            <begin position="247"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD83986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="387" mass="41266" checksum="9DB6474DB2A37374" modified="2017-06-07" version="1">MSNEVYIIGAGETKFGELWDKSLRNLAVEAGLKAVEDAGIYSKDIDAIYGANSLAGIINMQENIGALIADFSGLSTEGIPSLRVESSTASGGAALRDAYLSIKSGEYDVVVVGGVEKMTDIHGSDILEKSSSILDREWEAFFGATPAAMAALIARKYMHDFGVEKEALSMFSVNDHLNGSKNPDAQFRNKLTIQQAMNSTAVADPLNMMDCSPMSDGAAAVVLASESFIKKNKREGVRILSSAVAEDYLSVGSRKSIYTLNSTKLAVEKALRKSGIKRNDISFMEVHDSFSIFGLLELEDLGFAEKGKAKDLVYDEIKLNGSIPVNPSGGLKAKGDPYGAVGVGQAVDAYRQLKGKAGDNQIKDAKYALLHNMAGTGTSSIIHILGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1M3</accession>
    <name>A0A1V0N1M3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine--pyruvate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143132.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1M3"/>
    <dbReference type="STRING" id="74969.FAD_0118"/>
    <dbReference type="GeneID" id="84218608"/>
    <dbReference type="KEGG" id="fai:FAD_0118"/>
    <dbReference type="OrthoDB" id="35685at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF39">
        <property type="entry name" value="SOLUBLE HYDROGENASE, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="4">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="371" mass="40963" checksum="4EA58EB73D0346B8" modified="2017-06-07" version="1">MLLIPGPVEVPYSVSNAGSIVSNHRSPEFKNVVKENESLLNKFSGAYKTVMVTGSGTLAVETMVFSLINNNDRVLSISYGNFGERLIDSIAKKTTNTQFIRYDQLNIDTLLEEIRSRDFDKLFLVHNETSNGTAIRDLTEIIKIVKEKGAKLLVDDVSGFAGYNMDMNGIYAMVTGSQKNLASIPGIGIIFLSIEAYNDVMSQASTNTPFYLDLKTSLNFLEKNETAYTPSTGAFISLNYALKILEKEGFASRVKRITSSADFIRSSLADKGVEIFGTKDTYSSTVVCFYNNDPDMVKKLAEHGITVSKGMGKLANTTLRIGTMGMINNHYIEKFLNSYFKISGKNIIIKESDIPPSTRLPDFLVDDVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1V3</accession>
    <name>A0A1V0N1V3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH bat-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841592.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1V3"/>
    <dbReference type="GeneID" id="31675656"/>
    <dbReference type="KEGG" id="fai:FAD_0144"/>
    <dbReference type="OrthoDB" id="202021at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236:SF1">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH bat-type" evidence="1">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="214" mass="25384" checksum="95D39503FBD659E4" modified="2017-06-07" version="1">MFVRCCMQILYSFKYENCFASKLINDFKIRIKIVEQEFRDKYIYETLSLYSESEDILKKTIDYLENYKHSEDVTIVEKGANFVTLNVVAKSCPLVEVMKKKLMNSDSKIKLERIDYSGNLFWELNVSNYNKIRHIDDTLREIYDIKDSNIKTFNGRRISIKSEYILKEAFERGYFDVPKKIGLKELSSTLDIPPTTLDLLLRRQLRQVIQQTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1V4</accession>
    <name>A0A1V0N1V4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps14</name>
        <name evidence="8" type="ORF">FAD_0173</name>
        <name evidence="9" type="ORF">HLB00_02285</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds 16S rRNA, required for the assembly of 30S particles.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000069">
        <property type="protein sequence ID" value="NOL59662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887178.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1V4"/>
    <dbReference type="STRING" id="74969.FAD_0173"/>
    <dbReference type="GeneID" id="32192133"/>
    <dbReference type="KEGG" id="fai:FAD_0173"/>
    <dbReference type="OrthoDB" id="5615at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_uS14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_uS14_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="52" mass="6193" checksum="C578CA42F8AF100A" modified="2017-06-07" version="1">MQVKLQPKKNFGHSQGCVRCGRKRGLVRRYGIRMCRQCFRETAEKIGFRKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1W7</accession>
    <name>A0A1V0N1W7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfocyanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">soxE</name>
        <name evidence="4" type="ORF">FAD_0154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74969.FAD_0154"/>
    <dbReference type="KEGG" id="fai:FAD_0154"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010532">
        <property type="entry name" value="SoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049544">
        <property type="entry name" value="SoxE-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03094">
        <property type="entry name" value="sulfo_cyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfocyanin-like C-terminal" evidence="3">
        <location>
            <begin position="49"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="NCBIfam" id="TIGR03094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="173" mass="19247" checksum="670B582311F221D6" modified="2017-06-07" version="1">MNTIMSDQGAVSHRDIPYYNTTINGTHVEVVNLSLAAWGQGNGYPNAYPFNFNGTSYGAMTIYLPANADIHANMTNYEVKPHTLKFELPYSSQWSTGPIWAHTSVHVKKVIASTGTIDPIWYGNVAHYRSIWWNDTASGHYWVVCGLTTHAEAGMYAFVIVSSSVTTPYYTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1W9</accession>
    <name>A0A1V0N1W9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141377.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1W9"/>
    <dbReference type="GeneID" id="31675662"/>
    <dbReference type="KEGG" id="fai:FAD_0151"/>
    <dbReference type="OrthoDB" id="57485at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009272">
        <property type="entry name" value="DUF929"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06053">
        <property type="entry name" value="DUF929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="251" mass="27882" checksum="796B87DD21083834" modified="2017-06-07" version="1">MTEERKNNRKLLAFFIVFFVVIAFLAIYGAEHYDAHDETIELEQYCKVSDSDLIKDNTSTFVYYITWDGSPTGDAGSWAVYDFLNSTGFNMTGKFIETQSMSGYQYNNTPGLIFNTSYTYSVTYDHRNTIIVPVYLYGENLSKNTTPEAGLKALKADVPPSVYSVIKGYTTEAIVNGPCMPSDNISSIPHINSVTLITGPSGAYLLNGYIVKPDYGNATPEKVLQDVNQNIHDYGINTGMEGLEATIKDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Z4</accession>
    <name>A0A1V0N1Z4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="14" type="ORF">FAD_0233</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141424.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Z4"/>
    <dbReference type="STRING" id="74969.FAD_0233"/>
    <dbReference type="GeneID" id="31675742"/>
    <dbReference type="KEGG" id="fai:FAD_0233"/>
    <dbReference type="OrthoDB" id="10073at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="13">
        <location>
            <begin position="263"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="533" mass="60689" checksum="EC3A76DAF8B7DD70" modified="2017-06-07" version="1">MVVIKENKDDLIHEIGINYYSKLSDFAGIIGYSIEEENNEVKLEFNPDRPDLFSFYALKSNMKIFYDGNYRIKPLFEKSDKLIRVDNSVKSERPYVMSFVARGKPLGNYYSHIIDYQEKLHETIGKSRKKMAIGIHDLDNISPPFLFTMRDKKTLEFTTYDNFHGTAREILEKHDKGKQYRQLISSDTMVPVILDSKEDVMSMPPIINGLKSKIGNNTSKLFFDITGTDYNAVLSAFYLFAYEMSYIGYEVLIPDADRNTINYDWRKVEITHKEITKLMGLEPDNTVILLRKMGYRCEVTSGGYRVDVPGNRIDVMGPVDIIEDIAKAYGYGRIPARPLKTSGTGVPYTPNEDENIIKGILTSINYQEVRSFILNSEDFYRKTGYSGDVIITNPKSLEYSVIRDKLYPGIISLLAINKRRKLPLKIFEIGQVVVSGNQESHLCVLYNNSKAAYSDIYAVLEYLLARTINAGAKVLQGNYNEIISGRGGDIVYENTTLGIIGEMDPSILVDFGIQNPVAFMEINLDKLRNIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N214</accession>
    <name>A0A1V0N214_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific tyrosine recombinase XerC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xerC</name>
        <name evidence="3" type="ORF">FAD_0255</name>
        <name evidence="4" type="ORF">HLB00_03120</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000099">
        <property type="protein sequence ID" value="NOL59825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887277.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N214"/>
    <dbReference type="STRING" id="74969.FAD_0255"/>
    <dbReference type="GeneID" id="16025422"/>
    <dbReference type="GeneID" id="31675764"/>
    <dbReference type="KEGG" id="fai:FAD_0255"/>
    <dbReference type="OrthoDB" id="3343at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349:SF87">
        <property type="entry name" value="TRANSPOSASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="411" mass="47700" checksum="E1790AE7061CCCAB" modified="2017-06-07" version="1">MAIYGVERDIKSEHTRLGKINAEARNAILDFVDEVKITGITGFRELFYLTKLRIIYNNLQDKFLNPDKRAIITMLLDFKKKYTDQTLIDYENVMKRFYRWKFGTLPDYMANLKVSRKPSHDKKMDLITRADIDEMINNCNNARDKAIISIPYDSGCRIGEILDLRIKDVVYDEYGALLHVHGKTGNRSVRIIGDSIAYLRDYLKTKDGRDEYLFTGLQGTTMHKQLQYTAIRRLFINVRRRAGIEKRIYPHLFRHTRASMLASKVPEAPRENQMGWVHGSQMTAIYVHLSGRGQDNAILKAYGIHVDEDRIIEEKPKKCPRCDHLNASTALYCTNCFMPFNEKLALEYKDKENNIVSTLKSSSVIPGMTKSILEKAPEGFKNKMIEEILEEILKDPELLKRFKEESRNGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N226</accession>
    <name>A0A1V0N226_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD kinase</fullName>
            <ecNumber evidence="8">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nadK</name>
        <name evidence="9" type="ORF">FAD_0266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>NAD(+) + ATP = ADP + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141436.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N226"/>
    <dbReference type="STRING" id="74969.FAD_0266"/>
    <dbReference type="GeneID" id="31675775"/>
    <dbReference type="KEGG" id="fai:FAD_0266"/>
    <dbReference type="OrthoDB" id="77798at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002255">
        <property type="entry name" value="PRK01185.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF43">
        <property type="entry name" value="BIFUNCTIONAL NADP PHOSPHATASE_NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="6 8" id="KW-0521">NADP</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="170"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="271" mass="30122" checksum="201F599612E53E41" modified="2017-06-07" version="1">MKIGIIARINCHSCIKIARRIIELIPESWELVLEDKLAKALNMKGVNFKDIDADIIIVVGGDGTILRTAQLSRGKILGINVGGLGFLSEVEIGNIEESIYNLIKGNYKTYEVMKLNVYVNDQLFGKGINDVVIHTARISKIRKFSVYINDRFMENTSADGVIVATPIGSTSYSYSAGGPILIPSLKAMVISYIAPFGSRLRPIVCPDDSKITIKIIGRFSSLVIIDGQREAVVNGNDRIDIRVSDERLTFIELKNSFYDRLREKLIKDVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N233</accession>
    <name>A0A1V0N233_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141455.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N233"/>
    <dbReference type="STRING" id="74969.FAD_0290"/>
    <dbReference type="GeneID" id="84218790"/>
    <dbReference type="KEGG" id="fai:FAD_0290"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="142" mass="15723" checksum="C9562B5E78341ECE" modified="2017-06-07" version="1">MNRYNTFFSAGLAIVVLTYLFIFLLPGNSLSKYFQSGYYYGIIPRIFPIFLIFGDVFVVAGLLFPLRNFNKHKDYLVTAAAIFIVAGVLFALVLHVSPLDGSQDNGLKAGYLIVEGVILLFFTLIISYYISADSLGSDNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N236</accession>
    <name>A0A1V0N236_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps15</name>
        <name evidence="7" type="ORF">FAD_0245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887263.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N236"/>
    <dbReference type="STRING" id="74969.FAD_0245"/>
    <dbReference type="GeneID" id="16025408"/>
    <dbReference type="KEGG" id="fai:FAD_0245"/>
    <dbReference type="OrthoDB" id="6533at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="144" mass="16874" checksum="38F736F8221450B1" modified="2017-06-07" version="1">MARMHTRKRGKSRSTRLVLAEKPSWMQNDDEIKEEILKFRKDGLSNSMIGIKLRDQYAVPGVRPVLHQKMGKILEENGIKDEIPEDLAFLLKRYKNVSQHLALNKKDISNKRGSQLIMSKILRLMRYYKRTGRLPADWSLKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N244</accession>
    <name>A0A1V0N244_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquione biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_201800959.1">
        <property type="nucleotide sequence ID" value="NZ_DAIEUE010000074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N244"/>
    <dbReference type="STRING" id="74969.FAD_0298"/>
    <dbReference type="KEGG" id="fai:FAD_0298"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050154">
        <property type="entry name" value="UbiB_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566">
        <property type="entry name" value="CHAPERONE-ACTIVITY OF BC1 COMPLEX CABC1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566:SF113">
        <property type="entry name" value="PROTEIN ACTIVITY OF BC1 COMPLEX KINASE 7, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="108"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="501" mass="57446" checksum="B8031318939D1344" modified="2017-06-07" version="1">MNRIEMRYLAKLLPVFLRFSSDRKKSKKQEEYDYKIENHGRAAVNAFIELGPTFIKLGQVLSARPDLLPKEYLKAFSDLQDKVPPDNFVYAKQIIEENVGKMETVFESFDENAISGASLGQVYRAKYKGRDAAVKVNRHNIDNVLKRDLIIIKKLLNMFKRFIDNYLYISISNVLSDFSARIYDETNYLVEAENIKRIGNNIKKYDIIIPEVLFASRQVIILTYIGGIKVTDVKKLKEKGIDLPKLAHNLDLTFIRMLLRNDIFHADPHPGNIAISDDGKIILYDFGMVGKLDDDTRFKLLKLYDGLINKDPDTIMDSLLQLNALSPAANRGIIRKGIELSIANLSGANVNEMDIRELLEIANNVIFEFPFHLPRELVLYMRMSSLLEGICKTLDPNFKFVLVLRDILYNEGMLQELYLKEMNEFAQKSIISIEKGLDVLPLLKRALEERNGETNENKKLPSTVFLSAILIAMVLFSRSHPVISYIVIIIDIILFAYIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N245</accession>
    <name>A0A1V0N245_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methylmalonyl Co-A mutase-associated GTPase MeaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0300</name>
        <name evidence="8" type="ORF">HLB00_04285</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000147">
        <property type="protein sequence ID" value="NOL60052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141470.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N245"/>
    <dbReference type="STRING" id="74969.FAD_0300"/>
    <dbReference type="GeneID" id="84218800"/>
    <dbReference type="KEGG" id="fai:FAD_0300"/>
    <dbReference type="OrthoDB" id="21324at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052040">
        <property type="entry name" value="GTPase/Isobutyryl-CoA_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43087:SF1">
        <property type="entry name" value="LAO_AO TRANSPORT SYSTEM ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43087">
        <property type="entry name" value="LYSINE/ARGININE/ORNITHINE TRANSPORT SYSTEM KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03308">
        <property type="entry name" value="MeaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="314" mass="34672" checksum="B0C617A531909CA6" modified="2017-06-07" version="1">MNIERLTDGILHGDYRSIARSISLIENSGYELRKEIISRIYRHGNAKIIGITGPPGVGKSTLIGNLAPKLSEHGKVAVLAIDPASPFSGGSILGNRIRMQTALSKKNIYMRSTSNRLFNGGLSEYTWDIIKILEAAGNKFIILETVGSGQSDVDVMNIADITCVVLAPGLGDEIQAIKSGIMEIGDIFIINKIDREGSYMAIKDIRESLNMSNKLSTPVIGLNSITGENYGELIDNILRMDKKNVKEKYYRKLKMTVMETIYSDYSKYIDSIEDDKNVPDEDPYTMAEDILKSRPAGGERPEIRNTENSGETGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N268</accession>
    <name>A0A1V0N268_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141433.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N268"/>
    <dbReference type="STRING" id="74969.FAD_0264"/>
    <dbReference type="GeneID" id="31675773"/>
    <dbReference type="KEGG" id="fai:FAD_0264"/>
    <dbReference type="OrthoDB" id="12267at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051598">
        <property type="entry name" value="TSUP/Inactive_protease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN MJ0441-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701:SF2">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN YJNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="283" mass="29723" checksum="95EF8095545EF760" modified="2017-06-07" version="1">MIDVTLIQYILAIISGIAVGFSLGLIGGGGSILAVPLFIYFVGINHPHLAIGTTALAVGITAYINFAQHLRRKNANIKLGGVFALVGIVGVLVGSTIGLIIKGGELLFFFSMLMIIIGIYMYISKCRAVPNEDCKELAKQTNYGKVSGYSLIVGFASGFFGIGGGFLIVPGLLASSKIKINMAIGTSLLAVGTFGIVTAIRYSIVAPGLQFISSGMIGDVLFLVAIVYVIGGIFGGYLGTKLSVNLGGRKGTLRKVFSIIIILVGIYVAYESYPALVHMLFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2A8</accession>
    <name>A0A1V0N2A8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2A8"/>
    <dbReference type="STRING" id="74969.FAD_0369"/>
    <dbReference type="KEGG" id="fai:FAD_0369"/>
    <dbReference type="OrthoDB" id="147673at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOG1 N-terminal helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="178"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="339" mass="38983" checksum="6ED152D15BE82203" modified="2017-06-07" version="1">MKRILTSLKLGCMFDYIPTVLRSQEIIDKSFHKASNIVEPYFPKKEMKIRKEVTDRISTIESISTGHLDKIIRKFPTIETLHPFYFDLIDLMFDVDKYKLSLGNVQWTTDKIKDFSTVYIKKLKGVKTINEMNNIMKQYYGRFSSLIKNINKDLLYLGECRNYLRRLPGIITDIPTFIIAGIPNSGKSSLIQKLTGTTPDIASYPFTTKEILIGYKNIGTRRVQFIDTPGILDRPMDDRNDIERRAIIALSKIEGTILFLFDYSGTSSYTEDQQNNLFNEISGSFPNKIIRIQTKIDISERKENKCISSVTSPGLKELDDVVIAEVENFYAARNQETGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2B2</accession>
    <name>A0A1V0N2B2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">type II site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="6">3.1.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.21.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.21.4" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141484.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2B2"/>
    <dbReference type="STRING" id="74969.FAD_0313"/>
    <dbReference type="REBASE" id="195973">
        <property type="entry name" value="FacYORF312P"/>
    </dbReference>
    <dbReference type="GeneID" id="31675822"/>
    <dbReference type="KEGG" id="fai:FAD_0313"/>
    <dbReference type="OrthoDB" id="109475at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019045">
        <property type="entry name" value="Restrct_endonuc_II_HinfI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09520">
        <property type="entry name" value="RE_TdeIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="259" mass="29533" checksum="B524820CB94F5942" modified="2017-06-07" version="1">MSLTEIQIKNVENVLRNALRNKFQTYKPETSSMPFHVRLLGKDRLALYSFIHSLSTNFGTSIFEPVAVTLAKGRFKNVKSHTSVGDYISTQSQNEIQRIIDNLITASSSPNKIKEIEAIRKVCKSGDMVRVKPTLVDLFLEDKNGVFYLFDLKTAKPNIGNFKEFKRTLLEWAAVILASNPDSYVNTLIAIPYNPYEPAPYNRWTMRGMLDLSTELKVAGEFWDFLGGEGTYKELLECFERVGIELRSEVDSYFASFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2B5</accession>
    <name>A0A1V0N2B5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Regulatory protein moxR related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0357</name>
        <name evidence="4" type="ORF">HLB00_08490</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000318">
        <property type="protein sequence ID" value="NOL60860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141533.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2B5"/>
    <dbReference type="STRING" id="74969.FAD_0357"/>
    <dbReference type="GeneID" id="84218855"/>
    <dbReference type="KEGG" id="fai:FAD_0357"/>
    <dbReference type="OrthoDB" id="24581at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050764">
        <property type="entry name" value="CbbQ/NirQ/NorQ/GpvN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42759:SF1">
        <property type="entry name" value="MAGNESIUM-CHELATASE SUBUNIT CHLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42759">
        <property type="entry name" value="MOXR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002849">
        <property type="entry name" value="AAA_ATPase_chaperone_MoxR_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-3" evidence="1">
        <location>
            <begin position="41"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="ChlI/MoxR AAA lid" evidence="2">
        <location>
            <begin position="232"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="317" mass="36360" checksum="664A46975A79F440" modified="2017-06-07" version="1">MEETENIRDTIIDMETSIGNTVIGSSRIVRFMLISLFTNNHILMESVPGLAKTMLASEFSKHLGLQFKRIQFTPDMLPSDVTGNMVFNPETRKMEFREGPVFSNIVLADEINRTPPKVQSALLEAMEEKQVSVYGLTTKLPSPFLVIATQNPIEQEGTFPLAEALMDRFLFRYYIDYPDREDEIKILKSIYRNAAKKYNTLDSATILHYRNLVNEVYVNEEIIEYIINIIRKSRESDMVYLGASTRTAVKYLNAARANAMLSGRKYVIPEDVIFIAREILNHRLIMRPEALIDSEADYRKIIYNVIDSIINSVEAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2D3</accession>
    <name>A0A1V0N2D3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <shortName evidence="15">FBP A/P</shortName>
            <shortName evidence="15">FBP aldolase/phosphatase</shortName>
            <ecNumber evidence="6 15">3.1.3.11</ecNumber>
            <ecNumber evidence="15">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fbp</name>
        <name evidence="16" type="ORF">FAD_0332</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6 15"/>
    <dbReference type="EC" id="4.1.2.13" evidence="15"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887351.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2D3"/>
    <dbReference type="STRING" id="74969.FAD_0332"/>
    <dbReference type="GeneID" id="16025498"/>
    <dbReference type="GeneID" id="84218831"/>
    <dbReference type="KEGG" id="fai:FAD_0332"/>
    <dbReference type="OrthoDB" id="5829at2157"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02067">
        <property type="entry name" value="FBP_aldolase_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041126">
        <property type="entry name" value="FBP_aldo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE/PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341:SF1">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015647">
        <property type="entry name" value="FBPtase_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="Sulfolobus fructose-1,6-bisphosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 15" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton acceptor; for FBP phosphatase activity" evidence="15">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor; for FBP aldolase activity" evidence="15">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DHAP; for FBP aldolase activity" evidence="15">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD84254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="381" mass="42389" checksum="085FFE0718ABEDD5" modified="2017-06-07" version="1">MKTTISHIKADIGSLPGHTVVYQPVVDEVENYVKNNSEGLISDFHISHIGDDIQITMVHTRGADNPEIHKLAWDAFKAGTEVAKKIGLYGAGQDLLKDAFSGNIKGMGPGVAELEITPRKAEPFIVYMMDKTEPGAFNYPIYKMFGDPFNTPGLVIDPNMHMGFKFEVWDIYNGKKIYLSLPEDTYDLLAFIGSKSKYVIKRVYTKNTHTKLPDENVAVITTDKLSFIAGEYVGKDDPAGIVRIQSGLPASGEALEPFANSYLVSGWMRGSFNGPMMPVGMDNAQMTRFDGPPRVMALGFVMKEGKLAGPVDMFRDVAFDYARNEALNMANYMRRMGVFEPHRLPDEDMEYTALPKILEKRAQDFKKIEDKGANSEMKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2G6</accession>
    <name>A0A1V0N2G6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2G6"/>
    <dbReference type="STRING" id="74969.FAD_0376"/>
    <dbReference type="KEGG" id="fai:FAD_0376"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052924">
        <property type="entry name" value="OsmC/Ohr_hydroprdx_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="159" mass="17273" checksum="2815EAD47B9F52FF" modified="2017-06-07" version="1">MVELEKTENKIKSSGGHLFVEKHINGEFNLSGSPMFTAELGSEKAKFILGADEPGILGGQGVHATPLNYLMMGVMSCFASTVAIQAAKRGIVLKKLKFKGHLYYDIGPVVVESDFPIIKSLKIEVEADQDIKVVLEHSKKACPALYAIMNPIPTEISQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2G7</accession>
    <name>A0A1V0N2G7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FAD_0378</name>
        <name evidence="15" type="ORF">HLB00_00640</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Berkeley</strain>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 28986</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000016">
        <property type="protein sequence ID" value="NOL59346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887399.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2G7"/>
    <dbReference type="STRING" id="74969.FAD_0378"/>
    <dbReference type="GeneID" id="16025545"/>
    <dbReference type="KEGG" id="fai:FAD_0378"/>
    <dbReference type="OrthoDB" id="4488at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005002">
        <property type="entry name" value="PRK06392.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331:SF1">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="13">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="150"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="NOL59346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="327" mass="36177" checksum="1D0F191F6D87EC85" modified="2017-06-07" version="1">MDVSLVGLGHIGKAVVGILNENHEYFKTRFGSDIHVISVSDSKTTVYDKNGLNLDKVLMYKERGELDEVADVMKMEDIYSLNSDVIVDMSPATKDGLAGMRMYKNAFDSGKQVVTCNKAPLALHWKEIMESSRKQKKNILYESAVGGGVPLFNLNRYSLKSSKLLEFKGQVSSTINFVLNHLMGNVDFHEAIKTAQSMGIAETDYHDDTNGLDGARKTVIIANALLGLDYTLKDVEYDGIENLDNIEYMRNSGEVYRVLSHITAGTNPIIESKIFSIKPGDSMAAMDSLSMGYLEKTDNNDDLMVFEKHDGPLETAAQVVNDILLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2H7</accession>
    <name>A0A1V0N2H7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="6" type="ORF">FAD_0388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141560.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2H7"/>
    <dbReference type="STRING" id="74969.FAD_0388"/>
    <dbReference type="GeneID" id="31675896"/>
    <dbReference type="KEGG" id="fai:FAD_0388"/>
    <dbReference type="OrthoDB" id="15305at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009977">
        <property type="term" value="F:proton motive force dependent protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371:SF0">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="274" mass="30821" checksum="913926B4D766A97C" modified="2017-06-07" version="1">MENQLLNYLVKYSDEIRARLIKILEVFGILFGIFVIFRLQYISLLGYRFMFLYPDPYDNIGAQILFLLKAHTLTTDTTLLVLKPVDGVMADFYTCMAIALIISMPVIIYEVSKFIDPALKTSEKEMLRSIILPASLLFFAGAFVGIYFIAPILFKIFASFDIGVGADVTMGISSFVSFMFMYTIAFGLSFEIPVFMVGLSRFGIVTADTWKKNWRYAVIGSLVYGMIFSPGVTGFTMVVIAIPMIALYFAGIHFAINAEKKFEEDQAYSNSADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2I8</accession>
    <name>A0A1V0N2I8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940591.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2I8"/>
    <dbReference type="STRING" id="74969.FAD_0396"/>
    <dbReference type="GeneID" id="31675905"/>
    <dbReference type="KEGG" id="fai:FAD_0396"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017271">
        <property type="entry name" value="Tscrpt_reg_HTH_MJ1545_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037724">
        <property type="entry name" value="TF_HTH_MJ1545_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="205" mass="23091" checksum="AB83BFB743D20A5C" modified="2017-06-07" version="1">MDISEKIAGEITISDTPGVTIKKWREEFGISQMELSKFMDVSPSVISDYESGRRKSPGANSIKKIVDALVKIDESRGGHLVRRYNSGIPSDALLDIKDYDHDIELRYILTKIRGTPCSTANLKRNIRGYTMIDGIKAVLKFSYAEYTKLYGWSSQRIIFITDVSIGRSPMIAIRAHPLKPAAVVYVKPDNVDELAIKLLKLKIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2J0</accession>
    <name>A0A1V0N2J0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF3494 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ice-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887486.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2J0"/>
    <dbReference type="SMR" id="A0A1V0N2J0"/>
    <dbReference type="STRING" id="74969.FAD_0431"/>
    <dbReference type="GeneID" id="25398814"/>
    <dbReference type="KEGG" id="fai:FAD_0431"/>
    <dbReference type="OrthoDB" id="57559at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021884">
        <property type="entry name" value="Ice-bd_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11999">
        <property type="entry name" value="Ice_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="64487" checksum="9F87DEF78C42F0FA" modified="2017-06-07" version="1">MYKKHTIKITLVILISIILILSSSMLFLGQSQNSGNSGVSAAPFLSGSYNVSFNETGLTSGTQWNVVLNGTSRTSTSSSIVFSEVNNIYSYTIGNVSGFSVKSVSPASPVTVNGAAITVNVSFTKLAPVSISPVNLGTAGNYAILAKTGISNTGTTSIVGNIGVSPASSTYITGLSLTMNSSGQFSTSSMVTGNVYAATYASPTPSTLTTAVGDMQTAYTNAAGRTNPNYVNLGAGDLNGMTLVPGLYKWGTGVSISTSITLTGNSSSVWIFQISGGLTFGNGAHIILSGGAQPQNIFWQVASGATIGTGATFYGTILSQTAITIATGSSMTGLALAQTAVTLQSDTITAPLEPQSITAAMYGVTFTEAGLPSGTQWNVTLNGVLLSSTVPTISFSEPNGTYAFSVASSTADKIFPSTGSIIVNGEIAYQGITFAAPNQATYTVAFNESGLASGTQWGVTLDGITTTTISSSVNFTMTNASYPFSIIVPADYSATPSTGTETVNGNNITVLVTAVLIVYPVTFKETGLPSGTTWYLNITSMASSGPLTGTTYTVSLLNGSYAYTASSTDSAYHAVKGTFTVSGHSTSETAKFSKVSTSISNTDIYIIVGIVVALAVIGTAVAIMLRKGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2J6</accession>
    <name>A0A1V0N2J6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0443</name>
        <name evidence="2" type="ORF">HLB00_03835</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000124">
        <property type="protein sequence ID" value="NOL59963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141598.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2J6"/>
    <dbReference type="STRING" id="74969.FAD_0443"/>
    <dbReference type="GeneID" id="84217028"/>
    <dbReference type="KEGG" id="fai:FAD_0443"/>
    <dbReference type="OrthoDB" id="56816at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="156" mass="17571" checksum="BAF0400BA7E31AB9" modified="2017-06-07" version="1">MAEENKETETTEDENVVRKTISIKGVSADLYRRIQKISNDTGKTIGQVTDDAYKSFMGTVENAKHLSDGFMKGMKEGSSQFIENIKELEITGNDLKEIGRKIIFKNIESLTFKDIDNETFDKYVNAIIMVKTVTIPKGLSKAKILLKGNFIDKIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2J7</accession>
    <name>A0A1V0N2J7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141592.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2J7"/>
    <dbReference type="STRING" id="74969.FAD_0438"/>
    <dbReference type="GeneID" id="31675947"/>
    <dbReference type="KEGG" id="fai:FAD_0438"/>
    <dbReference type="OrthoDB" id="57355at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="2">
        <location>
            <begin position="70"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="274" mass="30276" checksum="A083EAE002921550" modified="2017-06-07" version="1">MKIASVTIDNKNHLALYREGKLALLDDYGIKATSVAELSHDDFAKLKDINRFQDYTFSYNSIIDQKSSLLCIGLNYKSHVSEHAGGKIPETPVVFSKANNAFTGNHSIVQTGNGMHVDYEGELCVMIGKTARNVGEANALNYVLGYFIGNDVSSRLMQYKTTQFFLGKSFDNFYPNGPYISIGEINDPQNLTIQTRVNGELRQDSNTGLMIFPVNKLISYISQFMTLRPGDCISTGTPAGVIMGMPESNQKWLGKGDKVEVQITGLGKLETTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2L3</accession>
    <name>A0A1V0N2L3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0407</name>
        <name evidence="3" type="ORF">HLB00_05030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887439.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2L3"/>
    <dbReference type="STRING" id="74969.FAD_0407"/>
    <dbReference type="GeneID" id="16025585"/>
    <dbReference type="KEGG" id="fai:FAD_0407"/>
    <dbReference type="OrthoDB" id="120822at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07514">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01487">
        <property type="entry name" value="Pglycolate_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01482">
        <property type="entry name" value="SPP-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="NCBIfam" id="TIGR01487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="223" mass="24842" checksum="F1ABF59848F8D183" modified="2017-06-07" version="1">MIKIMALDVDGTITDQNRIICPEAITSIKKGIESGLQISLISGNVIPVMYGLKTFLGINAPVFGENGGIMYYNGSIEKFFDKTKPLEFLEYISSRSLATPYFTNQWRETSAAFSMDPGNEAIVSKEAEKWNLEIVNSKFTWHIMNPGQNKGYAVEILKKMFNANWDEILVVGDSDNDNAMFTLPVKKACPDNATDSLKSISDYVSPESYGYEIGDVMAKFNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2R5</accession>
    <name>A0A1V0N2R5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class-III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141658.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2R5"/>
    <dbReference type="STRING" id="74969.FAD_0538"/>
    <dbReference type="GeneID" id="31676044"/>
    <dbReference type="KEGG" id="fai:FAD_0538"/>
    <dbReference type="OrthoDB" id="6534at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF58">
        <property type="entry name" value="LEUCINE_METHIONINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="437" mass="48888" checksum="8EF2C25A36DB8A57" modified="2017-06-07" version="1">MALNDYKNLPKIITDVPGPESKLLLQRQREMESSTVIYPDSFPIAIKRAENSLIEDLDGNIFIDWVSGISVLNLGFNDKIRDAVKAQLDDIWHALEIPTEVRINFLEALRNSFPPEMRNYKTIFGISGADACETAINIAHAIRKKNAPTIAFEGAYHGVSGGIIAATAGRKYREAVYSDGFKIIRVPYPYKLWYDYDVSDIISIMKKIMDDGEAGYDRPDSVIVEPVQGEGGYIVPPDGFLKAIREFCTEYDLTMIVDEVQSGVGRTGKMWAFEYENITPDIVCVSKSIGGGLPVSLVYYRDDYDKKLPKPFHLGTYRANPLAMAAGITVINEVPKYFDKVKSSGKEMLNKFNKIDSNLIGEVRGKGYMIGIELVDNGKPMNSKHMMELKHELLQNGLLMHTCGHYGNVFRFMGALNMPDELINTGINIFGKVLRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2R8</accession>
    <name>A0A1V0N2R8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0480</name>
        <name evidence="7" type="ORF">HLB00_08835</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000332">
        <property type="protein sequence ID" value="NOL60924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887536.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2R8"/>
    <dbReference type="STRING" id="74969.FAD_0480"/>
    <dbReference type="GeneID" id="16025683"/>
    <dbReference type="KEGG" id="fai:FAD_0480"/>
    <dbReference type="OrthoDB" id="8183at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="195" mass="22619" checksum="65E9A101710B84E7" modified="2017-06-07" version="1">METSYSLIRNEWKHLKKSSIYGLQKERMISWRRGNSIERVDRPTRLDKARNVGYKAKEGYIVVRARVRRGGQHKPKIMGGRRPRRLAYTKMTLKKNIQVIAEERVADKYPNTEVLNSYYVGEDGLYKYYEVILVDKATPAIYNDSKISWIVEPQNKGRAYRGLTSAAYKNRGLGHGRLGSDKSRPSIRANGRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2W6</accession>
    <name>A0A1V0N2W6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0566</name>
        <name evidence="6" type="ORF">HLB00_00660</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000018">
        <property type="protein sequence ID" value="NOL59350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887623.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2W6"/>
    <dbReference type="STRING" id="74969.FAD_0566"/>
    <dbReference type="GeneID" id="16025773"/>
    <dbReference type="KEGG" id="fai:FAD_0566"/>
    <dbReference type="OrthoDB" id="10712at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42756">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42756:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OF EMRAB OPERON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH marR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="143" mass="17014" checksum="BC83F06B36F95B75" modified="2017-06-07" version="1">MDKISSYDVWREFLRTWKTWYKASEKNLMSMGVSTVEYRILKNLTERGALPMIELANINMVTQGWITGVIDKLEKLSYVMRERSDSDRRVINITVTPKGKAFFKTIESRHLKFIDDTLRNFSYEERYNILNFLKKIETNVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Z7</accession>
    <name>A0A1V0N2Z7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">dnaK</name>
        <name evidence="9" type="ORF">FAD_0533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887590.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Z7"/>
    <dbReference type="STRING" id="74969.FAD_0533"/>
    <dbReference type="GeneID" id="16025739"/>
    <dbReference type="GeneID" id="31676040"/>
    <dbReference type="KEGG" id="fai:FAD_0533"/>
    <dbReference type="OrthoDB" id="9944at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10234">
        <property type="entry name" value="ASKHA_NBD_HSP70_DnaK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000001">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000071">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="575"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="579"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="628" mass="67834" checksum="6C08BD4029275078" modified="2017-06-07" version="1">MSKIIGIDLGTSNSAAAVVISGKPETIPAAEGVSLGGKSFPSYVAFTKDGQLLVGEPARRQALLNPEGTIYGAKRKMGTDFKYKIFGKEYTPQQISAFILQKIKKDAEAFLGEPVNDAVITVPAYFNDNQRQATKDAGAIAGLNVKRIINEPTAACMAYGIDKLNETLKILIYDFGGGTLDVTVMDFGQGVFEVMSTSGDTKLGGSDMDEAIVNFLADDFKSKEGIDLRKDKSAYIRLRDAAEKAKIELSTVLESDINLPYITATQDGPKHLEFKLTRAKLEELIAPIVGKSAASLDKALEGAKLSKGDINKIILIGGPTRMPYVKKYVEDYFGKKSEGGVDPMQAVATGAAIQGGVLMGDIKDIVLLDVTPLTLGIETVGGVMTPLINANATIPTKKTQVFSTAADMQTSVEIHIVQGERPLVKDDVSLGNFVLTGIAPAPRGVPQIEVTFDIDANGILNVSAKDKGTGKSQSISISASNKLSKDEIEKMKKEAEQYAEEDKKEKETIETLNNGESLAYTVEKTINEAGDKLDNETKDKIKGIIKDLKDAVEKKDVDKVKEITENLTKEMTEVYTKMAQAQQPDQGAGQQSEQQSEQQGEEGSSQEQNNNEQQSDDSTVNTDYKENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N377</accession>
    <name>A0A1V0N377_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase subunit K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887684.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N377"/>
    <dbReference type="STRING" id="74969.FAD_0626"/>
    <dbReference type="GeneID" id="16025833"/>
    <dbReference type="KEGG" id="fai:FAD_0626"/>
    <dbReference type="OrthoDB" id="56168at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004320">
        <property type="entry name" value="PRK05715.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434:SF16">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="99" mass="10819" checksum="517F607667F16489" modified="2017-06-07" version="1">MNIIYILFLSMILFTIGIYGVTTSKVGMKVIISLEIVLNAALLDVVGVATLYYSTSVVVFALFVIAIGVIESTVGIAIFTLISKKYGKINISLLRDIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N390</accession>
    <name>A0A1V0N390_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase subunit J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887683.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N390"/>
    <dbReference type="STRING" id="74969.FAD_0625"/>
    <dbReference type="GeneID" id="73909250"/>
    <dbReference type="KEGG" id="fai:FAD_0625"/>
    <dbReference type="OrthoDB" id="124473at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="entry name" value="NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="73" mass="8068" checksum="8E218A7EF259B266" modified="2017-06-07" version="1">MKNKAQKIAAIVFIIVIGINLLTINKSFAIKPQDITDIGTLLFSTYIVPFELLSVLLVASIIGVMYIVEDDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3A5</accession>
    <name>A0A1V0N3A5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XshC/Cox1-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0726</name>
        <name evidence="4" type="ORF">HLB00_01130</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000031">
        <property type="protein sequence ID" value="NOL59440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141851.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3A5"/>
    <dbReference type="STRING" id="74969.FAD_0726"/>
    <dbReference type="GeneID" id="84217349"/>
    <dbReference type="KEGG" id="fai:FAD_0726"/>
    <dbReference type="OrthoDB" id="33067at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052698">
        <property type="entry name" value="MoCofactor_Util/Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30388">
        <property type="entry name" value="ALDEHYDE OXIDOREDUCTASE MOLYBDENUM COFACTOR ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30388:SF6">
        <property type="entry name" value="XANTHINE DEHYDROGENASE SUBUNIT A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC- CoxI" evidence="1">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC Rossmann" evidence="2">
        <location>
            <begin position="125"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="248" mass="27828" checksum="ADEDF172CCE3E60E" modified="2017-06-07" version="1">MYDDIIPLQTSLQNNKKDYAIATVIKTAGSSIAKPGFKILASGKNILYGTLGSPSLDKVVLGELNASIEKQETKYLKIALDKDNKTSDYSMNTTCGGMIELFIEPYVHRRNIVMLVESNDDKLLEAMMGLMDYTGMEPVVININKKEETDKLMSEDYSEDFVVLLTKTENEIKFISHFLKNKPVYLSIVSSKNRFNKDIEQVKTQYPGLDTSLIKCPAGIDIKAITINEIAISIVAEIIKEKNLHHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3A6</accession>
    <name>A0A1V0N3A6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IS605 OrfB family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3A6"/>
    <dbReference type="STRING" id="74969.FAD_0736"/>
    <dbReference type="KEGG" id="fai:FAD_0736"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010094">
        <property type="entry name" value="Transposase_put_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01765">
        <property type="entry name" value="tspaseT_teng_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="5">
        <location>
            <begin position="157"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="6">
        <location>
            <begin position="280"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="374" mass="42771" checksum="43FFCE2A5EA1AF31" modified="2017-06-07" version="1">MNIVLKTLQIKLLPDDNQKALLLGTFKKFNEACNFVSRIAWDNKIYNKISLQKLVYYDIRNKFGLSAQLTIRVIAKVVDTYLTDRSVFHEFREYGSIVYDQRIMSFKSMYEVSLNTIKGRIRIPITIGKYGEIPFNRMRGQCDLVRKHKIFYLMVSVDIKEQPVIEPKNVIGVDMGIVNISVDSTGKYYSGDRISEVREHNSDLRSRLQSVNTKSAKRHLKKLSGKEHRFATNTNHIISKEIVNKARGTSSAIAIEDLSGIRMRETVKKGNKYIHNSWAFYQLRLFIEYKAREAGIPIIVIDPHNTSRECPNCHTISKKNRPERSAFKCISCGLEGEADYIASLNIRNRAVANQPIVAGDFFVHCDTPVASSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3B3</accession>
    <name>A0A1V0N3B3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3B3"/>
    <dbReference type="KEGG" id="fai:FAD_0681"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="75" mass="8947" checksum="7453A7C9472CEAAD" modified="2017-06-07" version="1">MDSIDSDIRELYKQNKRIPPEKFMIILLTVMSINSAIIIVSLYQKSLFIRIVLELVSGILMVSYFLWFFLRIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3B8</accession>
    <name>A0A1V0N3B8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA C-acetyltransferase (Acetoacetyl-CoAthiolase) (AcaB-10)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141805.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3B8"/>
    <dbReference type="STRING" id="74969.FAD_0698"/>
    <dbReference type="GeneID" id="31676200"/>
    <dbReference type="KEGG" id="fai:FAD_0698"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF2">
        <property type="entry name" value="LIPID-TRANSFER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase C-terminal" evidence="2">
        <location>
            <begin position="243"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="383" mass="42204" checksum="41DC2F41504CEE2E" modified="2017-06-07" version="1">MIRGFSEAIYKNYDGTAYEIMNEALNKSLSMAGLERKDIDGFMTTFLPGVFDGNVYMHFFPDQICNYLGIKPKYIDSMEYGGPSVLSAFWRAEHIIKSGVAENILLLFGGKGSAVRKKKQTVDSIENLYSDITNTPYKPLLSGYNYTNPVSDYALLAQRHMKIYGTTDEQRASLIVKQRENANRSGYSMFTGSITVEDVLGSPIISSPLHLLEIVYPVDGFHAFIVSKNSGKLREISILKYGEAHQSALPPEIDDITITPAAESSSSFRGDIKKCDFYELYDSFSITVMIQLENTGIVPPGKSGEFLEKNSISVNGDFPLNTGGGSLNRGQPAYMSGSVLLYEALLQMNGMAGRNQVKTPDKAFINGMGGWARNHSVSMILGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3E6</accession>
    <name>A0A1V0N3E6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">2-oxoacid:ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">2-oxoglutarate ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_0713</name>
        <name evidence="13" type="ORF">HLB00_07230</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000265">
        <property type="protein sequence ID" value="NOL60620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143149.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3E6"/>
    <dbReference type="STRING" id="74969.FAD_0713"/>
    <dbReference type="GeneID" id="84217336"/>
    <dbReference type="KEGG" id="fai:FAD_0713"/>
    <dbReference type="OrthoDB" id="30755at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03375">
        <property type="entry name" value="TPP_OGFOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053399">
        <property type="entry name" value="2-oxoacid:Fd_oxidored_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051457">
        <property type="entry name" value="2-oxoacid:Fd_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041171">
        <property type="entry name" value="Oxoac_fdxbeta_Archa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48084">
        <property type="entry name" value="2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48084:SF2">
        <property type="entry name" value="PYRUVATE FERREDOXIN_FLAVODOXIN OXIDOREDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="10">
        <location>
            <begin position="55"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate ferredoxin oxidoreductase beta subunit C-terminal" evidence="11">
        <location>
            <begin position="206"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL60620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="316" mass="34611" checksum="33E4B73C9CF02B72" modified="2017-06-07" version="1">MQKSVSDKGSGYNFRNNITIDWCPGCGDFGIVSAVTQALSAMKMDPQDVVAVSGIGCSGKTPHYLNIAGTHTLHGRAIPYAVGVKLANPNLNVLVMGGDGDLLSIGAGHFVGEGRRNSGVKVLLYNNSVYGLTKGQAAPTLPLGEKVKSLPRPNILGKINPITLAMASGYSFVARAFSSEIKQLSELIQRAIKHEGSAVIEVLQPCPTYNDVNTLDWYRQRVYKLEDDKSWDPVVNSKEEDEAKFDRGYRKSLEWGDHIPIGIFYENNTIPSYTKRLAGVIPDYLKYPPALQDVSDRDGYTIVDPIKTFSENDIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3F4</accession>
    <name>A0A1V0N3F4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily multidrug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0778</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141956.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3F4"/>
    <dbReference type="STRING" id="74969.FAD_0778"/>
    <dbReference type="GeneID" id="31676280"/>
    <dbReference type="KEGG" id="fai:FAD_0778"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17321">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF46">
        <property type="entry name" value="BLR6921 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="7"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="464" mass="51020" checksum="0FF8138F08317173" modified="2017-06-07" version="1">MDHRYGILTVTTLSTLMAAIDSTIVYLALPAMGQTFHSGISYLTLVVAAYIISTTVMLVPAIEITKRIGNRNFYIIGFSIFTVSSLIIAVSLNIAMVIIFRFVEGIGAGIMTSSDIPIILGAFRKGERGKAIGLNSIAWSIGTLIGPVLGGFLVAINWRYIFLINVPIGIGTMFAGYKIIKKDKVDKLPIKYKSTISMALFLIPLIMGIALINEYYLLIALIILPVFIYVQIKQPVIDRKLLGNIRFSLITLASFLESFVFFSVLFALSLYFQSDLGLSSIDTGLIIFTYPVASIVSSPIGGILYDRYRHPETIMAIGTILECVPVLIIGIYLKYIPELLLIAGFGGSFFWSPSTTMITDALGEKFRVQANNAMFILRNIGIITAISILPLFILHFSRINVSIGEIFVSKARIDISAGIGAYLVFTAIISLSSLIFIFVYHRRARSSNTMDTAGVVDLQHRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3F6</accession>
    <name>A0A1V0N3F6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon monoxide dehydrogenase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141892.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3F6"/>
    <dbReference type="STRING" id="74969.FAD_0740"/>
    <dbReference type="GeneID" id="31676243"/>
    <dbReference type="KEGG" id="fai:FAD_0740"/>
    <dbReference type="OrthoDB" id="57164at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead" evidence="3">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="679" mass="74637" checksum="735F6443F6EEAAC8" modified="2017-06-07" version="1">MDYRDRYVDGKGKYIDDMTFDDMLYMNVFRSPYGKAKIKSVKGGFNASELKLFYKSSMGEMASLGGKSNSAYLEPVFAIDNVNYEGQPIAAVFGKTRYESEDLLNTVSVDYEPMQAVSGIDESLKAPPMHEGTENNILAEAELGEDFDENDIDFDLTLEDTFFNERIIANSMETRGCIADYKDSKLTFYVSTQSVQSVKAGLVQALGMKPEDVRVIQADTGGAFGSKGSFYPEYVMAAYASKKYGKPVKWIETRKEHLEAAYPGRGAKARIKIYARNDGRITGIKGDVYVDAGAYDAGTGGFASRFIAYQITGPYHIEKAYMRAYSVLTNKAPMGPYRGAGRPEAAFFMERMMDLLADRLQMDISEVRLVNASTEPFTSPTGLTVKEATRPFLEKALAEVNYSKISREEKTGIAFFVLIPASRPGESARIDVSNGKITAQLGGNVHGQGHELFVKSILENELQVEQNLISLENGDTAEMESGVGSWGSRTAIAGASALMKVAGQIKEQVIKKYGKYSPEKLLSGNYSAYDFLKIDYDVNSVNFNMITAERNRNGLVTMKDWYSYYDLGHVLSPVNVIAQITGGVLEGVGQMFSESLRYSPEGQLMTTSISDAGLLTSDYAPNCHIKWVENGSPSPSQAKGLGEAPTIGTPAALARAVELITRNRVVNTPIKLEDIENFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3G3</accession>
    <name>A0A1V0N3G3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glyS</name>
        <name evidence="12" type="ORF">FAD_0789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141979.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3G3"/>
    <dbReference type="STRING" id="74969.FAD_0789"/>
    <dbReference type="GeneID" id="31676291"/>
    <dbReference type="KEGG" id="fai:FAD_0789"/>
    <dbReference type="OrthoDB" id="6113at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000002">
        <property type="entry name" value="Glycine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="4"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="474" mass="54994" checksum="7D3EB6E32A94BBDC" modified="2017-06-07" version="1">MYDDIVELAKRRGFFWPSFSIYGGFAGFYDYGPLGVLLKDNIIRTWKESYMEDGAIFLDSPNITPEPVFRASGHLARFSDLAAECEKCKSKFKFESVLAFNKQDIIPANLEEAKKIASDTYLKCPVCGSRITNIYDFNLMYKVSGDYYLRPETAQGIFVNFKLLFNYNRGKLPMIVGQAGKGFRNEISPRQSLIRLREFNQCEIEVFLDPENLEFKSLYDYKKIKIKPNTGEELDITVKEAFERGLISSQAFAYFVLKTQNILENIGIESSKLRFRQHDPDERAHYASDSWDAEGLIDNEWFEIVGIANRTDFDLNNHQSSSGETMTTKIEEREFIPYVIEPSYGIDRILLTLMAQSLETRDGKNVLKIPYPVAPYHFAVFPLMKKENLKEKAEYIYENMKKQDKYIVYDEAGTIGKRYARQDEIGTPYCITVDYQTLEDNTVTVRSRDTAEQKRIKIEELLDLDFINSYIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Q5</accession>
    <name>A0A1V0N3Q5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative molybdopterin-guanine dinucleotide biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mobA</name>
        <name evidence="3" type="ORF">FAD_0900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142149.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Q5"/>
    <dbReference type="STRING" id="74969.FAD_0900"/>
    <dbReference type="GeneID" id="31676403"/>
    <dbReference type="KEGG" id="fai:FAD_0900"/>
    <dbReference type="OrthoDB" id="28434at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19136">
        <property type="entry name" value="MOLYBDENUM COFACTOR GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19136:SF81">
        <property type="entry name" value="MOLYBDENUM COFACTOR GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MobA-like NTP transferase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="181" mass="20995" checksum="E62801475DE04B73" modified="2017-06-07" version="1">MIAIIFAKNSQRLQNKHNMEICGEKMIDRISRILSETGRFSSIILFTKNFSLKSKFAVTEEDNTDGILFDSILYCIERYHEFLAIGGDMPYIDKGSIENILDNYKGNSVAYMSDNFYQPLFAIYSTDVEQPMLKYRKNGKGSIRKFMDEYSVSYIEGDQEKLKSINTEKDLIEARKNLRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3R6</accession>
    <name>A0A1V0N3R6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine amidotransferase class-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951110.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3R6"/>
    <dbReference type="GeneID" id="31676352"/>
    <dbReference type="KEGG" id="fai:FAD_0852"/>
    <dbReference type="OrthoDB" id="350529at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42824">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42824:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YAFJ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="230" mass="26251" checksum="B382298C7E6F0AF1" modified="2017-06-07" version="1">MFGYVGYSNEELDELYSALIEASRKDKIGEKYGYSSHDDGFGIAVYTEDNLFHFRSTKPIYKEKLNLPEFNGKIYAIFHALNAHDKDLISPIFEHPFIASNGNQVMYMAHNGVVDKQQLMENLGIKGVYNDTEAALEYLNKNGLNSISDLEDYTKSSLNVIILNLDKKSRSGTIYFKNFYHYKSKSDYLDMYTAVLPHGKAVVSSTLTLYGIDRYARVNTQSMTNLEEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3S7</accession>
    <name>A0A1V0N3S7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEPN domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">HEPN superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0918</name>
        <name evidence="3" type="ORF">HLB00_04070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000136">
        <property type="protein sequence ID" value="NOL60010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142184.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3S7"/>
    <dbReference type="GeneID" id="84217481"/>
    <dbReference type="KEGG" id="fai:FAD_0918"/>
    <dbReference type="OrthoDB" id="101044at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="128" mass="15319" checksum="66EAB25E725926E1" modified="2017-06-07" version="1">MSFSEAEILRKRASDFLEEGGHLIDIKKYDLAIFNLEQYCELILKYKMLIKLGYYPRTHSLKELINKLSELDDNIKDLVNNEKDLLYIGRLTDAYISARYMPFEFDEKETKNVYKFIVEVFNKYVNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3V5</accession>
    <name>A0A1V0N3V5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="4">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142103.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3V5"/>
    <dbReference type="STRING" id="74969.FAD_0873"/>
    <dbReference type="GeneID" id="31676377"/>
    <dbReference type="KEGG" id="fai:FAD_0873"/>
    <dbReference type="OrthoDB" id="2990at2157"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00438">
        <property type="entry name" value="cupin_RmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="RmlC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="DTDP-6-DEOXY-D-GLUCOSE-3,5 EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047:SF2">
        <property type="entry name" value="THYMIDINE DIPHOSPHO-4-KETO-RHAMNOSE 3,5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="179" mass="20716" checksum="60D0448BD042F736" modified="2017-06-07" version="1">MPFEITSDPLIKDVKIVNSKKFEDNRGFFEEVYREKILKDLNIQNKFAQVNLSFSKKNVFRGFHFQLNPAPQGKLITVVSGKIIDYGINLRKSSKSFKSHVEYEITTGKMIYIPEGFAHGFLALEDSYVLYLTTNEFNQSLDSGIRYDDKELNISLPDNIIISEKDKKLKYLNELALDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Y8</accession>
    <name>A0A1V0N3Y8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142279.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Y8"/>
    <dbReference type="GeneID" id="31676481"/>
    <dbReference type="KEGG" id="fai:FAD_0982"/>
    <dbReference type="OrthoDB" id="371918at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295:SF19">
        <property type="entry name" value="ARCHAEAL ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="43"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="229"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="447" mass="52453" checksum="90AE427D1DABC8E0" modified="2017-06-07" version="1">MKTQEELISILSNYNFWNKDIDTGVPRDNYVNNILRFLIDINIVTETGIRRSGKSYIARQVVNRWIRSHNKFDTLIINLDDERFIDADYNLLLDIYDAYSNLVKKSDNILIVLDEAQEIERWERFVRGLSEKGVKFLITGSSSKLLSSEFSTLLSGRSININIMPLSFTEFLSFNNIKISEQNAILFNMEKIAKLLEEYIKYGGMPAAVLHKDIKEDLIISYFDTIIIRDIIERYNVSNEHNLRYLIMYYLTNISSTITYNRISSSTKNNNRAIPVKSVQRYSNYIESTNIISFLDMFSYSLKEKENSPRKIFSVDNSFPYIIGFNFSENKGHFIENIVFQELLRNKYLLNFDLYYYKNGYETDFVIKLKAFIIPFQVTYKLNEGNIQREIKGITNFCKNFNLNSGVIINYNVEKVETVDGIQIQYVKLLNFLLNSNTYLLDLFHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Z2</accession>
    <name>A0A1V0N3Z2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142297.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Z2"/>
    <dbReference type="GeneID" id="31676490"/>
    <dbReference type="KEGG" id="fai:FAD_0991"/>
    <dbReference type="OrthoDB" id="56801at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="SLFN-g3_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Schlafen group 3-like DNA/RNA helicase" evidence="1">
        <location>
            <begin position="262"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="636" mass="73471" checksum="3E4259C26AEEE26C" modified="2017-06-07" version="1">MRLYQNSAQELINDLNYNKLSDKLKQSFVAYYGHNPSQGEYNAWNNSFQFIKNELQENKLYNIYVVIEYELPYSARRIDVILMGHGTENFKNIIIVELKQWSSAKLSEIEGNVITYVGHQEREVPHPSEQVAGYYYYMKDFMEIFNRDDYGLYGCSYCHNYSQTDKTLLDVSFNNVLSKFPLFTRDDFKKFGDYLKDKLSNGNGLDVYNDFITGDIKPSKKLIDYTSDILRNQKVFSLIDDQILANNTIIDRAKKAATFKHKSVIIVEGGPGTGKSVIALNAMAELLSKGFKVYHATGSKAFTSSLQKIVGSGDMRSVKNFFLYFNSVSHAITNEIDVLIADEAHRIRKSSNNRYTRPERRSTLPQIEELINSAKVSVFFIDEHQLVRPEEIGSIKLITEAAKKFGAKVYNFQLKTQFRCSGSDGYLNWIDSLLNINDTGNEFLSKNEKMEFKIVDDPQILRDEMNLRNSKNTNSARMVAGFCWPWSNPNENGTLVDDIVIGDFKATWELKDFAKIKFTKKPETPAWNLWPIDPSCSNQVGSIYTIQGFEFDYIFLIWGNDLVYDYSINDWVGKPENSKDPVIRKGKEKFTEHVKNIYRILLTRARYGVYVYFVDADTRKFVESRIEMYMVKNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Z3</accession>
    <name>A0A1V0N3Z3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated Cas4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas4</name>
        <name evidence="2" type="ORF">FAD_0940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Z3"/>
    <dbReference type="STRING" id="74969.FAD_0940"/>
    <dbReference type="KEGG" id="fai:FAD_0940"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37168">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37168:SF1">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF83" evidence="1">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="146" mass="17110" checksum="D4720D690523B8B9" modified="2017-06-07" version="1">MSLKNFYIIDKNQFVAHGDYLSKKKRRYGFTNIKLGRNVLDNLEITPNDNYIVHEFKRGKKVLPGDIFQVLHYMNILRTKGYTVENGEIHTLGSKDIKIIKLDEDAINELNTVYTELEKLRNEIIPDPIRNYYCNHGCSYSSFCWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N406</accession>
    <name>A0A1V0N406_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142309.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N406"/>
    <dbReference type="GeneID" id="31676496"/>
    <dbReference type="KEGG" id="fai:FAD_0997"/>
    <dbReference type="OrthoDB" id="58087at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010397">
        <property type="entry name" value="DUF996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06195">
        <property type="entry name" value="DUF996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="233" mass="25343" checksum="60D0045E9F625520" modified="2017-06-07" version="1">MNNAQKSQELKQARTYGIMGVILEFAGVPVFLIFKELGFIISIAGLILLFLAGKSISNYYSNQTPFKYMLYSLISGAILAVASTGLLVLVYVPGVSSATGANSISVINTSFLTLLLLVLFLFLVPGIVSIIFQYIAYNRVGKLIGSDEFHTASLFLLTGTISTITSIAIFIFYSDIPNNAMLLDIVRIIIFIGIVPILRGIVRLIVAFAKLPGEAKPSENNQNPNQSTYNEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N447</accession>
    <name>A0A1V0N447_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS605 OrfB family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142269.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N447"/>
    <dbReference type="STRING" id="74969.FAD_0976"/>
    <dbReference type="GeneID" id="31676475"/>
    <dbReference type="KEGG" id="fai:FAD_0976"/>
    <dbReference type="OrthoDB" id="56643at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF11">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE RV2885C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas12f1-like TNB" evidence="2">
        <location>
            <begin position="243"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="349" mass="39817" checksum="14E92A477F718EA0" modified="2017-06-07" version="1">MILTYKIKHGKDFSEELNKARLIAEFAIKTKSITSKDVKQFGLKSAISNQILRKYSRNWKAKDVHRIKLTVPHQGIKCSHEDRTITITPLKLELNYYFRNDFDKISQIELDNKFAYVSINIPDNNLIEPNGYLGVDRNTTGHIAVAGNPETGKIIKLGKEAGHVHKKYKNMRKNLQKKGKNRKAKRIKNRESRIVKDINHKVAKKIVQEAKNNGMGIKLEYLNGIRNAKSSKSFRYSLNSWSFYQLKTMIEYKARLLGIPVVYVDPYNTSKECSRCGQIGNRSGKSFKCPNCGHVDHADANASFNIALRPVFEEGIDQLYVDSDAYKGNTDIPKEATLGTETTLEHHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N449</accession>
    <name>A0A1V0N449_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142303.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N449"/>
    <dbReference type="STRING" id="74969.FAD_0994"/>
    <dbReference type="GeneID" id="31676493"/>
    <dbReference type="KEGG" id="fai:FAD_0994"/>
    <dbReference type="OrthoDB" id="57234at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050189">
        <property type="entry name" value="MFS_Efflux_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124:SF3">
        <property type="entry name" value="CHLORAMPHENICOL EFFLUX PUMP RV0191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124">
        <property type="entry name" value="PURINE EFFLUX PUMP PBUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="7"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="396" mass="42188" checksum="C4F0B5F7CFAA72BD" modified="2017-06-07" version="1">MDEKWFKLLSYWFLLFTIGFGWFILAPLVPELSSSFNVGLSSILLLVSTYGYTMVVLGLLAGWLSAKFTVKSSLYTAAGLSIIGLIGRALSPDYLSFLVTGIIAAAAYPLAMAPVGSVADSLFHDRSHTVIGISVGMLFLGMAFGSFFGPDIFTALGLKGAMWIPVILAIIAVIWLVPGIRGYPTSYKGRSLRGAFRIGMVKNWYIGLAISAMSVMFGSLGSTVLLLHHMATAQALAYGGLLGGLAFLGSALGALILPPVFEKYNRIRTGLITTGVLMFIFTAVMTLSLSYSTIVILIGAGYFFFGIFGNAYWSMAMTLTTRYVTDPAQAGFATSMYSVFTNLGVAFIPVFLGPEFGSLATIAVGVSVVLAIEVVAMILAPFLKVRASGAKETTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N450</accession>
    <name>A0A1V0N450_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142285.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N450"/>
    <dbReference type="STRING" id="74969.FAD_0985"/>
    <dbReference type="GeneID" id="31676484"/>
    <dbReference type="KEGG" id="fai:FAD_0985"/>
    <dbReference type="OrthoDB" id="7773at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="269" mass="30459" checksum="27BF4101DE45274C" modified="2017-06-07" version="1">MYAEKIYLLDYGWLGGDCGWFLPGAAGGAMTYSNRNPEKKWIEIPVSGALIQHKDGYILFDTGISPEAMKTHEKGLMEAFPITRISDENKLENQLKKINVKPADISFVVISHLHLDHIGQAGIFKDLKTPIIVQKTELESALSLLWQGKGGAYDISDLDPLRNANWFPINDEKFEIMDGVEAEFTGGHTRGHQVLNVKTKNKKYIFTGDYLHLPEEYNTESKGWLLSNANEWQDYMGKLKLKGKTGTNMVIGHDPDLWNKYPRAPNYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4B8</accession>
    <name>A0A1V0N4B8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-hydroxy-acid oxidizing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Lactate 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1093</name>
        <name evidence="8" type="ORF">HLB00_00875</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000025">
        <property type="protein sequence ID" value="NOL59392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886198.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4B8"/>
    <dbReference type="STRING" id="74969.FAD_1093"/>
    <dbReference type="GeneID" id="16024323"/>
    <dbReference type="KEGG" id="fai:FAD_1093"/>
    <dbReference type="OrthoDB" id="56968at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03332">
        <property type="entry name" value="LMO_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000029">
        <property type="entry name" value="L-lactate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037350">
        <property type="entry name" value="LMO_FMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF143">
        <property type="entry name" value="FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASE PB1A11.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="388" mass="43241" checksum="AF39857BA19991DB" modified="2017-06-07" version="1">MTQFGLDYQLKIYLKMDADSDLPVSLESWRSSARMALQDGPWGYLEGAAGSEDTMIENIKAFSRYRIRPRYLHDVENRNQSITLFGRKQDSPFIIAPIGVQSIIHKDAEYASAGAAASLGMPYILSTVSSTSIEDIAAKFPESEKWFQLYPGKDENVMKSMVNRAEKAGYKVIVVTVDTTMLGWREQDIKNAYLPFLQGEGIANFITDPEFLKMLETSPENNMQAAIEEFLMVYVNPSFTWDGFRKIRSWTKLPILIKGISSEEDVHTAVKYGADGVIISNHGGRQVDGSISSLEALDEITGENKPEFTILFDSGIRHAADAMKALALGASGVLIGRPYCYAMAVAGQRGIERYLNQLRAEFDLQMALSGYSSISQLGRHTIYKKSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4D0</accession>
    <name>A0A1V0N4D0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142461.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4D0"/>
    <dbReference type="STRING" id="74969.FAD_1075"/>
    <dbReference type="GeneID" id="84217674"/>
    <dbReference type="KEGG" id="fai:FAD_1075"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043958">
        <property type="entry name" value="Ta1207"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19020">
        <property type="entry name" value="Ta1207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="312" mass="36133" checksum="BECA85D79B4E0261" modified="2017-06-07" version="1">MKPVNFDLKLSKYFDISINFNSRQIALFRATGYNSAGCLIRDGHDFLFNLFIPKTDDITALKPFFQLVDIEEKARYYFYSEKIQDPYLSGFLGDLDSINGLVISYAGIESGKLKLQGFMHTNSETDFSNLLSKYNYMQVNIEKLTFKPSMGFYNFMKNMEIPLKSITISLPMSEFSQYQIIKVLKGTNTVIQYVDNITKGGKFRIILYSDSNLGNVEGIKVISDIDHIYETSIDESILVLFASNIIKNNITSNFTFMYESEDKLLLNFIVPEFMAKEYFRLIVDTEIDLKNFEWVTLESYGDLDNFERLFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4D5</accession>
    <name>A0A1V0N4D5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142471.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4D5"/>
    <dbReference type="STRING" id="74969.FAD_1083"/>
    <dbReference type="GeneID" id="31676581"/>
    <dbReference type="KEGG" id="fai:FAD_1083"/>
    <dbReference type="OrthoDB" id="42776at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="129" mass="14985" checksum="A1A94B56BE988A9B" modified="2017-06-07" version="1">MTTEEILKKYRDIAVVGISDKPDRASYQVSKYLMENGYNIIPVNPALEKWEGKRVYKDVKSIDGNVDVVDIFRKPEFVEEIVKDSKGKARVIWMQEGIVNEDAKKRAMDMGMEVIMDKCMKKEHEKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4E4</accession>
    <name>A0A1V0N4E4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1078</name>
        <name evidence="7" type="ORF">HLB00_06125</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000209">
        <property type="protein sequence ID" value="NOL60409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886184.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4E4"/>
    <dbReference type="STRING" id="74969.FAD_1078"/>
    <dbReference type="GeneID" id="16024309"/>
    <dbReference type="KEGG" id="fai:FAD_1078"/>
    <dbReference type="OrthoDB" id="15347at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF5">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="69" mass="7505" checksum="0B6D3B23D1A764F4" modified="2017-06-07" version="1">MEVKVKSEMDVDRGLCDYCGACVGMCPTDAINLDETVIAINEDKCIKCEFCVIGCPTGAISAEWFHAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4I4</accession>
    <name>A0A1V0N4I4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Daunorubicin resistance ATP-binding protein DrrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142525.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4I4"/>
    <dbReference type="STRING" id="74969.FAD_1141"/>
    <dbReference type="GeneID" id="31676639"/>
    <dbReference type="KEGG" id="fai:FAD_1141"/>
    <dbReference type="OrthoDB" id="87732at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582:SF2">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="279" mass="31278" checksum="1F760B595537AAFA" modified="2017-06-07" version="1">MIQIRELEKEYGKHQRALDHITQDLDSGIVSIIGKNGAGKTTLLRILSTQLKSSSGDAFIDGLSINKDIKEIRNKIVSIPQEASPIGILTAYEQVFLYLTGKGFSFHSARQESRMALKVVGLGDKMDVPTDILSGGMKRKMFVAMALGYNAETVFLDEPTTGLDPLSRMETWGAIKELTGNVVLTTHYMEEATELSRKIYMMDSGKFIGSGTADELLYDLRGKVRIESKEQMQGSYRIGNIYVKYVDKSDLDRYENLYYSIKQISIEDLFITRGVDLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4M2</accession>
    <name>A0A1V0N4M2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Riboflavin kinase</fullName>
            <ecNumber evidence="5">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FAD_1183</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>riboflavin + CTP = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142561.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4M2"/>
    <dbReference type="STRING" id="74969.FAD_1183"/>
    <dbReference type="GeneID" id="84217778"/>
    <dbReference type="KEGG" id="fai:FAD_1183"/>
    <dbReference type="OrthoDB" id="30955at2157"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706:SF1">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="12 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="18">
        <location>
            <begin position="98"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ARD85057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="220" mass="25088" checksum="A9BFD814CC7B54F1" modified="2017-06-07" version="1">MDYNLYNTIKILKKLSGSGNTVYISSGELAEELGVSQQTSSRFIIELADKKYIERTLQNRKQKITLLEPSLDLLYSELNQLNSILEMRQEFNLKGEIQSGLGEGKYYISQEGYMAQFLDKLGISPYPGTLNIKIFPEYENVLRRIRSADGIHIGGFKDKERTFGGVKCFSGRIDGTGAWLIFPERSNYTDIVEIISDKFLRKDLKLQDGDELNIRVALDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4N9</accession>
    <name>A0A1V0N4N9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142570.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4N9"/>
    <dbReference type="STRING" id="74969.FAD_1191"/>
    <dbReference type="GeneID" id="31676689"/>
    <dbReference type="KEGG" id="fai:FAD_1191"/>
    <dbReference type="OrthoDB" id="7466at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="239" mass="26576" checksum="CDCD52A6797E5B96" modified="2017-06-07" version="1">MERKYCTTRYGKLSYLDGNSGYPVIFLHGFGGTGNTWLKTAPYLEKCIRPVLVDLLGHGHSDKPDIEYIVKQQAESIVDLISTLEVSKFSIAGNSYGGWITLKLASGMLEPDMIFPVDSAGISPALSNGSRENMNRVLDSILKLRNYNNRNALERIMENNKKQEEKISDTALGNIKSKTTIIWGSADNIIPVSYGYAMESKISGSELIVMPDAGHTPFIDMPEEFAEIINRKIKEYALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4R6</accession>
    <name>A0A1V0N4R6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Inorganic phosphate:H+ symporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_1260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142700.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4R6"/>
    <dbReference type="STRING" id="74969.FAD_1260"/>
    <dbReference type="GeneID" id="31676758"/>
    <dbReference type="KEGG" id="fai:FAD_1260"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051084">
        <property type="entry name" value="H+-coupled_symporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="403" mass="44249" checksum="E8510CAC20180422" modified="2017-06-07" version="1">MKDLENIHLSEKISRMPWNSKHWIIFFTVSISFFMWGVTLAIAPLITTWYFVPQFSYYYIIGAAPAGLLAGNMSMGYISDRLGRKNIFLLTMGITVAGLIGIGASYNYIALIIFVFIAEFGLGGDETLSLAILIEYLPLKSRGFAIVESSNMANIGVTAISGLFLVYPSSVITQKILLIAIAIIAGGAALFARYHMEESGLWNLSKKLNEKLEITPRNTLKFLALTFMGMAIIVGFAFSDLVIGPFHFPEDTGLIIFFSVLAESLTGVIGGYYLGKSKRKSIAITGFSGLLISWAVIIIFLNSIIANLYLLLLMLAISSIFGEIGWAARELLEPENFISKYRGRGIGIIRSAGYVLYIIFIFALINASISTYAYFILAVYIAGFAGSLLYAGTGKETRFIPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4S0</accession>
    <name>A0A1V0N4S0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dihydroorotate dehydrogenase electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_1255</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="11">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142680.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4S0"/>
    <dbReference type="STRING" id="74969.FAD_1255"/>
    <dbReference type="GeneID" id="31676753"/>
    <dbReference type="KEGG" id="fai:FAD_1255"/>
    <dbReference type="OrthoDB" id="35401at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06220">
        <property type="entry name" value="DHOD_e_trans_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="entry name" value="Dihydroorotate dehydrogenase, electron transfer subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050353">
        <property type="entry name" value="PyrK_electron_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000796">
        <property type="entry name" value="PRK00054.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43513">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE B (NAD(+)), ELECTRON TRANSFER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43513:SF3">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE B (NAD(+)), ELECTRON TRANSFER SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD85123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="247" mass="27146" checksum="1188C84644440829" modified="2017-06-07" version="1">MKYFTIKENIRESRDVNTLTFEDDIKIKPGQFIMAWAPRINYIPLSFSSVSQIKSITVKIYGEASAYLAGLKPGDKLFYDGIYGNGYDVVQGKKLLIGAGSGIASLIPLIDEDTTGIISGKTGNDILFSSKFKKEKLHIVTDDGSMGKKGFVATAMDGLDIESFDMVYVCGPEIMMFSVLNYLKGMKVNCQFSLERSMKCGIGLCDSCSINGFQVCRDGPVFSIEKLKSMDEFGRTKLTSSGKRVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4T9</accession>
    <name>A0A1V0N4T9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1248</name>
        <name evidence="2" type="ORF">HLB00_03030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000097">
        <property type="protein sequence ID" value="NOL59809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142666.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4T9"/>
    <dbReference type="GeneID" id="84217843"/>
    <dbReference type="KEGG" id="fai:FAD_1248"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="83" mass="9826" checksum="229B931E6137F688" modified="2017-06-07" version="1">MDSTEDMKKLEDNITEQLDNFRQTAEKNFNEIYDKLNNQKLSEENEENLSLALTMMEALGIDILHLIRDYEDLVDYLDVLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4U1</accession>
    <name>A0A1V0N4U1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1263</name>
        <name evidence="3" type="ORF">HLB00_02950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000096">
        <property type="protein sequence ID" value="NOL59793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142702.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4U1"/>
    <dbReference type="STRING" id="74969.FAD_1263"/>
    <dbReference type="GeneID" id="31676761"/>
    <dbReference type="KEGG" id="fai:FAD_1263"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="1">
        <location>
            <begin position="183"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="366" mass="42019" checksum="CD83D6C34E566410" modified="2017-06-07" version="1">MIAITFVIPSSLDYNGGIEKTIARYNSYTTDDFKKIVLQGVPGGNNKDVYGINSVYSKLIISTSGKLNFLVRAMAPFILKFDRLLNYRVIRNIENNSQVIYLTNDDYYYLFAHGKFFVWSEHGNIPSSYTGIKPLNNAIYALIKDKLIFRKIKAMHLINCYNMNLAPFKNTFCVPNGVDTSHFFPSERAHSSIRLLFVGRLEKSKGIDKIVNVFKQNLLNIEFTVVGSGELESLFSTPVKNVNYVKNPDNEKLAEIYRNSDAFIFPSMLENFGNVVLEALSSGLYVIGSESLRPRFDDIEKMNFLEYIESTESAILKSLEDLDRKIEYTGKYENRIKMHNYIAGKYGWDVVLPQFYNKMKNAYYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4U9</accession>
    <name>A0A1V0N4U9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metF</name>
        <name evidence="2" type="ORF">FAD_1258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142696.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4U9"/>
    <dbReference type="STRING" id="74969.FAD_1258"/>
    <dbReference type="GeneID" id="31676756"/>
    <dbReference type="KEGG" id="fai:FAD_1258"/>
    <dbReference type="OrthoDB" id="28177at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38755">
        <property type="entry name" value="5,10-METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38755:SF1">
        <property type="entry name" value="METHYLENE-TETRAHYDROFOLATE REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="224" mass="25343" checksum="9A47B3C4B1A80425" modified="2017-06-07" version="1">MKTYAEIYPSKNLNNINDAIDALESFDGFNIPDNPLGYPTMPPEVIGYIIRQKFPGKDIIINQRLKDINELKVRSIITASKAINASIIFTQGDTPKFGKEFNEVSSSYAMKLAIHRGVESGLILSFKKPLNEILQRMQLKSNIFLVINMDNPSMLENLGTSRLIPYIIVKTKKNANILNKINQTSVDLEDLAIYMDTLNKYSLKGVLFSVPGDNETMENIRDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4W6</accession>
    <name>A0A1V0N4W6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886413.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4W6"/>
    <dbReference type="STRING" id="74969.FAD_1312"/>
    <dbReference type="GeneID" id="16024538"/>
    <dbReference type="GeneID" id="31676805"/>
    <dbReference type="KEGG" id="fai:FAD_1312"/>
    <dbReference type="OrthoDB" id="10490at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204:SF37">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR YODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="102" mass="11300" checksum="DCD15941322C5E58" modified="2017-06-07" version="1">MKTDDCPLSIALRPLRGKWEPLIIKYLSINGSSGYSEISNSMENITPKALTEALGKLSTEGIIGKNIISSKPVRVMYYLTDKGKAMIDPLDTIESLNKNRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Y4</accession>
    <name>A0A1V0N4Y4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MobA-like NTP transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142793.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Y4"/>
    <dbReference type="STRING" id="74969.FAD_1317"/>
    <dbReference type="GeneID" id="31676810"/>
    <dbReference type="KEGG" id="fai:FAD_1317"/>
    <dbReference type="OrthoDB" id="9782at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19136">
        <property type="entry name" value="MOLYBDENUM COFACTOR GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19136:SF81">
        <property type="entry name" value="MOLYBDENUM COFACTOR GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MobA-like NTP transferase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="174" mass="19525" checksum="D85A1909B3232216" modified="2017-06-07" version="1">MDRQYTQVDAIIMAGGKGSRMGTAEKMLLKVNGEKVIDAIIKILQNLNFNISLCISENTRFLDGYHSLRTIMGQGDYALDLNYAIKTCSLPVLIVPSDVIIKPDMIHDFVTSASSLDTAIATLIVNNKLSGISMFFKKPETGNLPYKNIEILRDDFFNLNCPDDYKKALHRFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N516</accession>
    <name>A0A1V0N516_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine adenosyltransferase</fullName>
            <ecNumber evidence="2">2.5.1.6</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="1">S-adenosylmethionine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1338</name>
        <name evidence="2" type="ORF">HLB00_03180</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000101">
        <property type="protein sequence ID" value="NOL59836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143173.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N516"/>
    <dbReference type="STRING" id="74969.FAD_1338"/>
    <dbReference type="GeneID" id="84217950"/>
    <dbReference type="KEGG" id="fai:FAD_1338"/>
    <dbReference type="OrthoDB" id="204488at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.280">
        <property type="entry name" value="S-adenosylmethionine synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.340">
        <property type="entry name" value="S-adenosylmethionine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042543">
        <property type="entry name" value="AdoMet_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027790">
        <property type="entry name" value="AdoMet_synthase_2_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042544">
        <property type="entry name" value="AdoMet_synthase_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003364">
        <property type="entry name" value="PRK04439.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003366">
        <property type="entry name" value="PRK04439.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36697">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36697:SF1">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01941">
        <property type="entry name" value="AdoMet_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="404" mass="44635" checksum="23B5662B1305763F" modified="2017-06-07" version="1">MESQLKVERNIQVEAIKQSPTMSREVEIVERKGIGHPDSVADGIAESVSRALSKYYLKQYGRILHHNTDQVEVVGGQADPKFKGGNVLDPTYILLSGRATASVGNERIPVKSLAIKSAKDYLREHFPDLDIDSDVMIDSRIGNGSVDLRGLYDTRKFKANDTSFGVGFAPFTDTETLVKLTEKYINGDLKKSLPAIGYDIKVMGFRKGRTINLTVAAAYVDKYVKDPSEYYAIKDELVNKIKDNAVKYTDEDVQVFVNTGDVKSDSVYYLTVTGLSMENGDDGSVGRGNRVNGIITPYRPMSMEAAAGKNPVTHVGKLYNVLSNQIADKVVKEEGGDIKEVLVRIVSQIGRPVDEPHVASLQLIYEDNVDPSKHKNNIRAIADDKLAHIEELTQMFVDGKADVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N555</accession>
    <name>A0A1V0N555_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine-hydrolyzing asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142857.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N555"/>
    <dbReference type="STRING" id="74969.FAD_1364"/>
    <dbReference type="GeneID" id="31676856"/>
    <dbReference type="KEGG" id="fai:FAD_1364"/>
    <dbReference type="OrthoDB" id="8692at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="242" mass="27925" checksum="880953AB279F46A7" modified="2017-06-07" version="1">MQNIVDNVYNELKAAVEQTADKPCAIAYSGGLDSSLLLALSGYRYIPYTLGFSDSRDIENVDDASSILKINPKIILLDEIDIEGYISQLLKIDPKITKMEMGYELVLFILMDFIPEKYVVTGQGADELFYGYRRFIDNPRLKNDTYINRLFNVTLPREKKMAEYYDKELITPYLSPGMLKIRHYITREDNIEGNRNKLILREIAAKTSLPEEIYNRSKTAAQYGSGINKYLLRQSDKIFRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N566</accession>
    <name>A0A1V0N566_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase of the PP-loop superamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142863.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N566"/>
    <dbReference type="STRING" id="74969.FAD_1374"/>
    <dbReference type="GeneID" id="31676866"/>
    <dbReference type="KEGG" id="fai:FAD_1374"/>
    <dbReference type="OrthoDB" id="33422at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054306">
        <property type="entry name" value="TtuA-like_LIM_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22082">
        <property type="entry name" value="TtuA_LIM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="2-thiouridine synthetase TtuA-like N-terminal LIM" evidence="5">
        <location>
            <begin position="2"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="311" mass="35449" checksum="55B941F2650EBFD3" modified="2017-06-07" version="1">MECSICGATAVYEVKYNGSALCKNHFITYVEKRVKREIREQVDFGSKKTRISVAISGGKDSSATLYLLHKILSERRNLELTAFTVDEGIEGYRSTGLEKARKLCENLGIEHNVISYKENYGYSLDEIMKIDKKTISCSHCGPMRRQLMNRISEYTESDYVALGINLDDYAQSILMNVAKGDVARYARMAPHSYTREGLVPRILPLRKIPEKEVVLYAILNGIDFDSSWCPYYSMAQRNSFRDIIEKLEKETPGTKFAIVKFFDETRKSIREHYVNENVKLNSCKICGAPTPGEICEVCSDLEHIRAIDNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N592</accession>
    <name>A0A1V0N592_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142873.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N592"/>
    <dbReference type="STRING" id="74969.FAD_1396"/>
    <dbReference type="GeneID" id="31676888"/>
    <dbReference type="KEGG" id="fai:FAD_1396"/>
    <dbReference type="OrthoDB" id="42542at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01309">
        <property type="entry name" value="Met_dep_hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="231"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="376" mass="42009" checksum="43264B566FFC3B8B" modified="2017-06-07" version="1">MKAVKANVLYDGNKKQKNVYVCFEGNTITEVTETKPYGEIIGEGVVTPAFIDPHSHIGLDRAGEPPYESEANDKLDSMLPLARAIDGVYMDDHAFTESVESNVIYSVVLPGSGNILGGMGSLIRNFEKNTKDAFVSDIGVKMALGYNPRSTTEWKGTRPTTRMGVAAIIRENFLAAQKAANLMSNGKKTIDEIDPKTEFFIKLISGEYKIMCHLHKEDDALFLMSLVDQFGIKPIINHGMDFHSEKIFEEIKKRDLSLVYGPLDSHPYKVELKHETWRNAELVKKSGVRFALISDHPVILQRNLFLTTRHFMRFGASKEQCISYVSSRPAQILGLDNLGTVEPGKLASFSIWNKDPFELDAYPAMVFGEGKLVHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5B4</accession>
    <name>A0A1V0N5B4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2004 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1464</name>
        <name evidence="3" type="ORF">HLB00_04490</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000152">
        <property type="protein sequence ID" value="NOL60093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886569.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5B4"/>
    <dbReference type="GeneID" id="16024694"/>
    <dbReference type="KEGG" id="fai:FAD_1464"/>
    <dbReference type="OrthoDB" id="56553at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1980">
        <property type="entry name" value="Uncharacterised protein PF09406, DUF2004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018546">
        <property type="entry name" value="DUF2004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09406">
        <property type="entry name" value="DUF2004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2004" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="124" mass="14908" checksum="FFE1652BBFCCED24" modified="2017-06-07" version="1">MKGVEIAFQTNKDGENDIVTALGNLTGNYFKNEENMDITWRIFHVTLDKEKYYRVLYKGEKISELHPENRKKIKEKFDQLSRTDYNALMAQYEKESRKQGFEKIGIKELTEEYDLWQDPLWNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5B9</accession>
    <name>A0A1V0N5B9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142902.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5B9"/>
    <dbReference type="STRING" id="74969.FAD_1437"/>
    <dbReference type="GeneID" id="31676929"/>
    <dbReference type="KEGG" id="fai:FAD_1437"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="530" mass="57495" checksum="AC10BF227D017835" modified="2017-06-07" version="1">MKHEYIVFTSFIVVIMFIIMAFSGITSQQNSQNNDISTSVIKPLSYGLTADKWSVSGKTCAPSSATIGNTVTLKIDVTSFSESKCAGPTIMYFYVNYKNVHTVDVSSTGVYTYNWNVGLNYGNINFHAEYLSESAWEDCPARLGFKPMVFFRNAYSTFGDSTIHVKKYLDVTGYDGNGSIYLSNICGAPGGLFYSIYHNFNITDSSGIYHGDNEANKSIIVGKTAYIESDNGKHLYISLNLTDVGAGAQSCSFDAKSGLSTCTRPYKLVTDLQTSGAPSDVSVQFCNNEEVGYNVTDMDSKSATEMQDEVSLIGDGFSLIPVAGYAVTGAQAAGTAYNLIHCVTTKPINGYATGNNLADIKYCITGGSMSGDSYVKNGQNVYASGIEANIKVPNSQLNSNFKIDIKYATEYECGSRLITDTRATTTQTINAVPASAICGSVGQSNTSQVRDPNLTSSLYIENANTHTFYNATIKNGTFLFFAQPDTTYKLYYMDNGKLHEFYHISNNKITGLNSITTSSAGNSTPLNIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5C2</accession>
    <name>A0A1V0N5C2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YrhK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142909.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5C2"/>
    <dbReference type="STRING" id="74969.FAD_1446"/>
    <dbReference type="GeneID" id="31676939"/>
    <dbReference type="KEGG" id="fai:FAD_1446"/>
    <dbReference type="OrthoDB" id="57486at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025424">
        <property type="entry name" value="YrhK_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14145">
        <property type="entry name" value="YrhK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="YrhK" evidence="2">
        <location>
            <begin position="256"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="319" mass="36477" checksum="7B7142E138DF2B1D" modified="2017-06-07" version="1">MLEHVDTGTHLYFLHMLQDNGMGIQFKWKEIKDISVAIFGDSIFDDIVKNEIVDTCSDNEILEVTNLNNIDSNLPRSQRESLYSAIIKFLSTDENVPGIMEIIYASRKIGRAIIDSINMNIIINKLEDRYINLRIAMAMASSMDFYYSVPFRSFCKTRLDKVQFSFDNYEKYLGDMWFIKIVLAMKDNTGEGLAYVKFPENSRLNYIETINGMAAGGLLASLFLHSAEFLSDTRVISAINRYEYNEIKKQRAGKFYGWVAIGNDVAIGLEFLSGSILFLSQADYFYGVYLFIAASIQLLVKPGIEIFRRARVSTMKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5E4</accession>
    <name>A0A1V0N5E4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142921.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5E4"/>
    <dbReference type="STRING" id="74969.FAD_1458"/>
    <dbReference type="GeneID" id="31676951"/>
    <dbReference type="KEGG" id="fai:FAD_1458"/>
    <dbReference type="OrthoDB" id="55804at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="155" mass="17518" checksum="F51AEAA2E0AD259F" modified="2017-06-07" version="1">MDVIDPDARIADLLGLLYVLNNIFDGKTDLYQMEKEMEVDLDDLMPIVYTASNIGLVNAESGDISISQKGIEYIKSGMNTRKQIIRDSLKNIEPFKTAISMSEFTLEDIIDKLKENDVPTFNNPDGTHDLEVILIEWGIYSRLLKKTDDGFQVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5F5</accession>
    <name>A0A1V0N5F5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142941.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5F5"/>
    <dbReference type="STRING" id="74969.FAD_1521"/>
    <dbReference type="GeneID" id="84218114"/>
    <dbReference type="KEGG" id="fai:FAD_1521"/>
    <dbReference type="OrthoDB" id="2305at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02068">
        <property type="entry name" value="radical_SAM_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026447">
        <property type="entry name" value="B12_SAM_Ta0216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051198">
        <property type="entry name" value="BchE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04190">
        <property type="entry name" value="B12_SAM_Ta0216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43409">
        <property type="entry name" value="ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43409:SF7">
        <property type="entry name" value="BLL1977 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00326">
        <property type="entry name" value="5''-pyrrole_methytransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding" evidence="8">
        <location>
            <begin position="26"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="555" mass="63178" checksum="DC011A5465A9D60E" modified="2017-06-07" version="1">MDADISLVHAPSIFDFRTRDIKLGPISDVIPSTPVFEMYPVGFISMLNSLISSGYNARICNVAAMMVSSASFDPVKYLKHVKSKIYGIDLHWLPHANGALKVAKIIKDLHPDSKVLLGGFSASYFADDIMTHYGYIDYILKGDLQETNIVKLAGAEDSYQALDRVPNLIYRKNNRIIHNKIEYSSIDDVFLNYGLLMKNAIKYHDIKGHLPYASWLDNTEAMTVIEHGCSFNCAFCGGSNFAYKNNYNSVAPLYRKPSVIAEEISLVEEMLGSPVFITGDMNNAGEKFYSSLFKELKDRKVSLPLLTEYFTPPGKEYLNELSHRFPDFTVEISPESSSEVIRNRNGRPYSNKGLEDFLQNAVTAGAKKIDVYFTIGMSGQTVNDVNADIDYSEKLMKKFSSAKEKLYTFISPLTPFIDPGSLIYEHPETYGFKITAKTITDYFNLLENGKIWTDFLNYYTNWMSVEQIARATYESEIRMIKMRQSLGLLKDVDADEIVKNITAYMHGDDYISNENKSSHLSYIEKDVEWSNKHKLTRDSFLISIYKDYNDFKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5F8</accession>
    <name>A0A1V0N5F8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transketolase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Transketolase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1476</name>
        <name evidence="6" type="ORF">HLB00_03100</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000098">
        <property type="protein sequence ID" value="NOL59821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841435.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5F8"/>
    <dbReference type="STRING" id="74969.FAD_1476"/>
    <dbReference type="GeneID" id="16024707"/>
    <dbReference type="KEGG" id="fai:FAD_1476"/>
    <dbReference type="OrthoDB" id="6779at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000129">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051157">
        <property type="entry name" value="PDH/Transketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF1">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="317" mass="35000" checksum="2C904721C0182EE1" modified="2017-06-07" version="1">MEKMDRMESLRDAYGKELASLGEKNKDIVVLDADLSSSTKTGVFGKKFPERFFNMGISEQSMVSAAAGLSLAGKTVFASTFAVFLSNTYNVIRQSICYNEAPVNFVVTHSGISLGEDGPTHQILEDVGIMSGLPNMKVIVPVDSIETVSVIDYLAARKTSPYYVRLTREKFPVLNDENYEFKEGKSVTFRDGSDVTIMGYGIMVSFALKAAEQLKNRGIDARVINMSSIKPLDRPAIIKAARETGKIVTAEEHSIYNGLGSRVAEVTSEEYPVPVMRIGMPDIFGKSGKGMELFDYFHIGVNDIVEKTDRFFKGDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5G2</accession>
    <name>A0A1V0N5G2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transketolase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142924.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5G2"/>
    <dbReference type="STRING" id="74969.FAD_1477"/>
    <dbReference type="GeneID" id="31676970"/>
    <dbReference type="KEGG" id="fai:FAD_1477"/>
    <dbReference type="OrthoDB" id="25494at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47514">
        <property type="entry name" value="TRANSKETOLASE N-TERMINAL SECTION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47514:SF1">
        <property type="entry name" value="TRANSKETOLASE N-TERMINAL SECTION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="275" mass="30113" checksum="9BB8B230632558C5" modified="2017-06-07" version="1">MESYTINDLNATAREIRKEIIKMVYSAKSGHPGGSLSIADVITALYFKEMNIDPEKPDKPDRDILIMSKGHASPAEYAALALRGYFPVELLEGFRKVNSKLEGHVHRGIPGVESSTGSLGQGLGVAIGFALSSKLDSKPNKIYAILGDGEMEEGNIWESLMAASKYHLGNLTAILDRNMIQLDGFTEDIMPLGNVAEKVAPFGWEVITINGNNMDEVVNALEYAKKPRDRPLFIVANTIKGKGVSYMENNPKYHGSPPANEEEYVQALKEIEGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5I1</accession>
    <name>A0A1V0N5I1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1560</name>
        <name evidence="3" type="ORF">HLB00_00980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841465.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5I1"/>
    <dbReference type="GeneID" id="16024831"/>
    <dbReference type="KEGG" id="fai:FAD_1560"/>
    <dbReference type="OrthoDB" id="56361at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40810" checksum="F1DC695BC576BEAA" modified="2017-06-07" version="1">MSFSYLEANGVFLKIVIAAMVTFLFSEFIAIYPIFSNYEKHKTVVLKHIVPIWEITGTMIVFFVVELELIYSGLVPISSYLFIPVIGLFVALLILRNVAIIYSEFIWKKVDSKPLMMFYSAATFLMVIGFVTAIAALMVGNSVSTAIPSLPPLLHLDLTNLSKSYVDYIALLTAPVYSAVYWEFLFGTLFIAFGMSQVFYRIAKRTSYIPLFTIILGLFLNVNAWNVVATLAGAKFMGDYMILPVIITIAIPLLYMYKPTTNLASYKPFWFIVMTIAVLFLELPITRIAGGAYSINTFASPNSMLVANFWLSMIGGILFLLLMIMYAYVYNSGRMSINPDKIEKTNKSNAEATEQAGKNEAQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5I2</accession>
    <name>A0A1V0N5I2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VapB-type antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Y</strain>
        </source>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A1V0N5J1</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
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        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="1 2" key="1">
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                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
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    <dbReference type="AlphaFoldDB" id="A0A1V0N5J1"/>
    <dbReference type="STRING" id="74969.FAD_1513"/>
    <dbReference type="GeneID" id="16024779"/>
    <dbReference type="KEGG" id="fai:FAD_1513"/>
    <dbReference type="OrthoDB" id="378975at2157"/>
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        <source>
            <dbReference type="EMBL" id="ARD85365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A1V0N5N6_9ARCH</name>
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    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
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        <lineage>
            <taxon>Archaea</taxon>
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                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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    <dbReference type="KEGG" id="fai:FAD_1566"/>
    <dbReference type="OrthoDB" id="88693at2157"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="53"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="347" mass="41078" checksum="58B1B6EF1AA48555" modified="2017-06-07" version="1">MDTFSDFMNYLDRNSDSMKKDLKLDKTSSIYKFYRDLFNSNYIKFKPSDPGKIDAAATDSSEFLRMLYNGKNIVIVRAFTLYNNEVTSDFHADLVAVDPVDQRNFTILLMEHSEHKSMLKFLDEHSPEYLFVDGSLKGRLSHRIETLPIEKYENFMYEYMKTLKELIRKSYEKGTTLIFMAKSSYTECFKKYLLETARNDPETMKIKEKESGIYRNDHYLIKSFAEESGYTTPVMYRKNLEGTDINYVSFDILPDPVDLPIKVQVLSKGFIKEDLDRKPYNLDEKIINILFYGYTGYKVYNLWLVDVDKKVKFRSVEMEKIYMRALERKLGIPFYETRGERRARIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Q7</accession>
    <name>A0A1V0N5Q7_9ARCH</name>
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        <recommendedName>
            <fullName evidence="3">RidA family protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
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                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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    </dbReference>
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    <dbReference type="STRING" id="74969.FAD_1578"/>
    <dbReference type="KEGG" id="fai:FAD_1578"/>
    <dbReference type="Proteomes" id="UP000192050">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13002" checksum="23833E295D418BDF" modified="2017-06-07" version="1">MHKSIVVEGLGRGGPYAHAVIAGETVYISGQTGQNENNQKDFKAQFRASMEKIEKIAESAGKSTKDIVKIGVYISDKSYFKEMNEVFGEYFKDSPPARTTLVSGFVADGILVEIDAVLH</sequence>
</entry>
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    <name>A0A1V0N5S1_9ARCH</name>
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            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 4">
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ARD85482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5S1"/>
    <dbReference type="KEGG" id="fai:FAD_1638"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="116" mass="13294" checksum="2B594388D3E89D41" modified="2017-06-07" version="1">MFGNIYTPNIAFFIYFIIIFAVLSISLTISFRRHRSDWSKSGQYFTLFIILASGIIAITLIVIGYPYSDRVFEYNSIQSRRYMLVVIYGVISLLIGLAGFIILRVKESKKGKLPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1V0N5V8_9ARCH</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="fai:FAD_1625"/>
    <dbReference type="Proteomes" id="UP000192050">
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052533">
        <property type="entry name" value="WalJ/YycJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47619:SF1">
        <property type="entry name" value="EXODEOXYRIBONUCLEASE WALJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47619">
        <property type="entry name" value="METALLO-HYDROLASE YYCJ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="244" mass="26955" checksum="DE20FBCEA3782D0B" modified="2017-06-07" version="1">MLSSGSRGNSTIIWDEYDAIIIDCGISMKKFSEKTSQFQIDGLEKSIFISHEHSDHSAGAKAISRKLKADLYSRSGTLEKLHLENSYSINGEVAIGNFTVTPVHVNHDAVDPVVYVIRNRGVKISVVSDLGIMNDELLDEMKNSNIMAIEANHDPEMLKNGPYTEALKRRIRSDHGHLSNEQSAEAIYSSASDGTSIILTHLSEKNNTPDIAINTVKSYLANRHKGYKSLEAASQEFGSTLYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5X2</accession>
    <name>A0A1V0N5X2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CofH family radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1710</name>
        <name evidence="10" type="ORF">HLB00_00095</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000005">
        <property type="protein sequence ID" value="NOL59239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143044.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5X2"/>
    <dbReference type="STRING" id="74969.FAD_1710"/>
    <dbReference type="GeneID" id="84218330"/>
    <dbReference type="KEGG" id="fai:FAD_1710"/>
    <dbReference type="OrthoDB" id="8186at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00423">
        <property type="entry name" value="CofH family radical SAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="FO SYNTHASE (COFH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076:SF1">
        <property type="entry name" value="LIPOYL SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004762">
        <property type="entry name" value="CHP00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00342">
        <property type="entry name" value="cyclic_dehypoxanthine_futalosi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01064">
        <property type="entry name" value="F420__menaquinone_cofactor_bio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01389">
        <property type="entry name" value="menaquinone_synthsis_involved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="53"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>(3R)-3-methyl-D-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:64642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>(3R)-3-methyl-D-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:64642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="365" mass="41179" checksum="DCC0DC2EDE214020" modified="2017-06-07" version="1">MISYGYIDTIEDKIKNGETLDENEIVSLYDSTSLRDLGRLARGITDKISGNRVSFVSNLILNYTNVCNVRCHFCAFYRTQNDGDAYTLSIDDVVNEIKTYYEPYGIRQLLIQGGVNSFLDLDYYTELFGRIKKEFPGLGIHGLSTAELHFISLKAHIPMKDLLIKLRESGLETIPGAGGEILDGSVRKRMGRPEASGRQWLEIMETAHKLGIHTSATMMFGHLETSLDKAHHLLSILELQKKYHGFLSFTPWNFEPGNTELAKEGYKYRSGGVSVLKNIAIARIVFNNELPIIQSSWLTNGMQMAQMAILFGANDWGGTIYDEKVIPATGKQVGNLRKEYIINSIKQINMVPVERDNMYNPVKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5X6</accession>
    <name>A0A1V0N5X6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795598.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5X6"/>
    <dbReference type="STRING" id="74969.FAD_1691"/>
    <dbReference type="GeneID" id="31677183"/>
    <dbReference type="KEGG" id="fai:FAD_1691"/>
    <dbReference type="OrthoDB" id="6995at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="69" mass="7687" checksum="40FEAD30464AC6BF" modified="2017-06-07" version="1">MPEHYTKTLEELRKLTFIKSLFSTSGDHSAIAIVISKLYGKSLNECIAEIEATEGVRNVYPSIVNSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N624</accession>
    <name>A0A1V0N624_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143048.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N624"/>
    <dbReference type="STRING" id="74969.FAD_1714"/>
    <dbReference type="GeneID" id="31677205"/>
    <dbReference type="KEGG" id="fai:FAD_1714"/>
    <dbReference type="OrthoDB" id="57271at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="439" mass="47399" checksum="BE99CEA5FAA231D3" modified="2017-06-07" version="1">MKYKVLIATMIAVVMVFSVFAMVPLSSGSQANSPALSGPSAAGFNDSIHTHFKNNYGAKLMYNSTTGMVMGKYLTADFNSSTGVFSNVTYNLTSTVLISKMYSNGTSIKGISSPILRFSTNSRTAYRIGNMFIMMNSTSFYVLHNNPTLESNMMVNGNLTLVVPSTANISYSTSNNTQVSISANNSLNAQANSNVFGNANMADHVMVNFNNTINAGRQMIVIDNNGTIAMLFIHNGNFKITNNTITISSNTSSGPVLVNMVAPPGLQKISNNSMVLSNIIHGRISSEIALNLVNGTIANSTINYNSSTHFVYTGKSSSTTSFDINSTVNHHTIVAVFIGNNVTKNTGHAYVKFDGRIATYVSMSTLVNETSSTHAYYSYTNTSSGMYVFMYVPHFSNHTMVVSNTPFHNTDYTEYYIGGGIIAVLAIIGVAAYAIKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N630</accession>
    <name>A0A1V0N630_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143032.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N630"/>
    <dbReference type="GeneID" id="31677187"/>
    <dbReference type="KEGG" id="fai:FAD_1695"/>
    <dbReference type="OrthoDB" id="9187at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8945" checksum="79A21F72BA20151D" modified="2017-06-07" version="1">MPSKNISISDEAYNKLKKLKGKNESFTAVINRLFSTITLLELRGTISNEDANGMRNSIVESREARREKIEKLFERWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N654</accession>
    <name>A0A1V0N654_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">2-oxo acid dehydrogenase subunit E2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase subunit E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1758</name>
        <name evidence="10" type="ORF">HLB00_08570</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000319">
        <property type="protein sequence ID" value="NOL60876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143071.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N654"/>
    <dbReference type="STRING" id="74969.FAD_1758"/>
    <dbReference type="GeneID" id="31677249"/>
    <dbReference type="KEGG" id="fai:FAD_1758"/>
    <dbReference type="OrthoDB" id="56234at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL60876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="384" mass="42334" checksum="0A0FD8FD6D3B6830" modified="2017-06-07" version="1">MYTVSLPPIGEGIQEGEIVKWTVKPGDSIRKDDELVEVMTDKITVKIPSPVAGKVSKILIKEGETAMIGDAMVEIDSPDESNSPEKPAEKPATTAHQEVSVSTDEKIPSVKATPAVRAYARSKNVDILKVKPAAQDGRITKEDIDAYMKQPAEPVAQKAPSEEDEVFTPTGIRKLIFDKMTKSKQIIPHFTITDFIDTENIEKAINQYSKKKYVSFTAFFVKAVTVAFRDFPKLNAVYNENDRTYTIKKKYNIGVAVDSPAGLTVVVVKDVASKNIFQISEEIKDMAERARNGKLGLQDVQGSTFSVTNIGSIGGIMATPIINYPEVAILEINTRTSGFVNGELKHGLYLTLACDHRLIDGAEAARYLEKLKEVLEYPLMYIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N664</accession>
    <name>A0A1V0N664_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipoyl synthase</fullName>
            <ecNumber evidence="8">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lip-syn</fullName>
            <shortName evidence="8">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">lipA</name>
        <name evidence="10" type="ORF">FAD_1755</name>
        <name evidence="11" type="ORF">HLB00_08555</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000319">
        <property type="protein sequence ID" value="NOL60873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886897.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N664"/>
    <dbReference type="STRING" id="74969.FAD_1755"/>
    <dbReference type="GeneID" id="16025030"/>
    <dbReference type="KEGG" id="fai:FAD_1755"/>
    <dbReference type="OrthoDB" id="145957at2157"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="44"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL60873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="284" mass="31849" checksum="9C952FA2B93F57E1" modified="2017-06-07" version="1">MMRVPYKVNLPTGERYSFIKNTINSRQLNTVCEEAHCPNISECWESGTATFMVLGSNCSRGCRFCAVTHGNMLPLDPDEPQKVYDSIKLMNLDYVVITSVDRDDLPDKGSSAFARVIEKVKELGIKIEVLIPDFGGDHADLDRIIAAEPDVIAHNIETVRRLTPSVRDPRAGYDQTLSVLKYIKGSMKGVITKSSIMVGLGETDEEVEETMMDLRNAGVEILTVGQYLRPTKKQLEVVEYSPMSRFKHFEEAGYEMGFSFVASGPLVRTSYRAAEGYIKMRDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N667</accession>
    <name>A0A1V0N667_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N667"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000046">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
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        <property type="entry name" value="PRK06460.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39829" checksum="48A8DA447C433063" modified="2017-06-07" version="1">MTSNRAYAAPLTYPIYQTSSYVVPEGEKYRYSREYNPTVENLGIKIKEMEGAEDYNVFSSGMGAITTTLLSLSKPGDRILTHLDTFARSYHFIRDFMGKWGIKPDIANPGTENIINGIKKGTGIVFIESVTNPILRVNDISTISEKCHDVGAILVVDSTVPTPYNVKSLKLGADIVVHSSSKFIAGHNNVISGLAAGRKDLMEKIDAMRRTLGTSLDPNSAFLTENGMKTLGIRMEKINSNAMEIATELQKNPEISRVIYPGLSEHPDHEIAKKYMKGYSGIVCFKVKTDPEKFIGKLEKIVPANTMGGTETVISTPASMSHRSLTSEELNVLGVDSTFMRLSVGIEDPDEIVRDINRALND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N677</accession>
    <name>A0A1V0N677_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Drug:H+ antiporter-2 family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886892.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N677"/>
    <dbReference type="STRING" id="74969.FAD_1750"/>
    <dbReference type="GeneID" id="16025025"/>
    <dbReference type="KEGG" id="fai:FAD_1750"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17321">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF46">
        <property type="entry name" value="BLR6921 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="8"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="576" mass="61813" checksum="34A6D68FC51C1A14" modified="2017-06-07" version="1">MVEEKWVALSNTTIGVLMATINMSILIIALPAIFSGIHLDPLKSNSFVYLLWILMGYMIVTAVLLVTIGRLSDIFGRVKLFNLGFLIFTIGSILLYLTPGKGDTGALELIFFRIVQAVGGSFIFANSYAIITDNFKKEERGFALGINAIAATAGMSIGIVVGGILATINWRYIFLVSVPVGILGTVWSYLKLKETSPKIKQKLDIPGNITFAGGLIILLVGVTYGIAPYKSSPMGWGNPWVIAALIIGAVLLVLFPFVERKVKQPMFNLSLFKIRGFATGSFAGMISSMGMMGFMFMIIILFQGIWLPIHGYHYASVPFWAGIYMLPMTIAMGIFGPIAGRFSDRHGQRWLASFGLIVSGIALLLLVLLPADFIYIFMGILLFVFGAGMGMFTAPNTAAVMSSVSPDVRGSASGMLTTLRNVGTTASMGIFFTILILGLTTSLPHTLSSAVISAGGGSTLAGEMSKLPPTEAIFAALLGINPGTVILGLLPAHVVSSIPTSAQHIIEARTWFPTIFAPAFIKSLHIVFYVGAAIVFAGAIISILREPLSKSKKTKADKKSAKDQSELPDKAVKMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N692</accession>
    <name>A0A1V0N692_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1792</name>
        <name evidence="3" type="ORF">HLB00_07985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000298">
        <property type="protein sequence ID" value="NOL60765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841529.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N692"/>
    <dbReference type="GeneID" id="16025071"/>
    <dbReference type="KEGG" id="fai:FAD_1792"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="202" mass="23510" checksum="101BD188CF867C0B" modified="2017-06-07" version="1">MRKSTIKYLVILIVIIIIISFTGYNFETEPKTNIKTTIDQKQLKNCIAKNITYELKYVNLTYGKSKVEYVIEYWYIPQIYTTGESGYIGNIQVYKLNQTLNFPLTSTAIEIKNINLKLNNFPGLFNKPAAYTWNNKTIEWSLCTVFHSSDNNSIYVSFNIVPVYNVWIYHFTGKPITFNYNYTLESRPSLYNNTVSQVGTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6A0</accession>
    <name>A0A1V0N6A0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1059 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1767</name>
        <name evidence="2" type="ORF">HLB00_04115</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000138">
        <property type="protein sequence ID" value="NOL60018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021787545.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6A0"/>
    <dbReference type="STRING" id="74969.FAD_1767"/>
    <dbReference type="GeneID" id="84219152"/>
    <dbReference type="KEGG" id="fai:FAD_1767"/>
    <dbReference type="OrthoDB" id="9023at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="65" mass="7921" checksum="EE7B246D1D4033C4" modified="2017-06-07" version="1">MTYYFKCKDLGWNCSFENHAEKREDIFPRIRIHFHYAHATNDIDEETMKKIESVIYEGEEYKGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6B4</accession>
    <name>A0A1V0N6B4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Alpha-IPM synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hcs</name>
        <name evidence="11" type="ORF">FAD_1836</name>
        <name evidence="12" type="ORF">HLB00_06905</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000246">
        <property type="protein sequence ID" value="NOL60559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886984.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6B4"/>
    <dbReference type="STRING" id="74969.FAD_1836"/>
    <dbReference type="GeneID" id="16025116"/>
    <dbReference type="KEGG" id="fai:FAD_1836"/>
    <dbReference type="OrthoDB" id="6555at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07940">
        <property type="entry name" value="DRE_TIM_IPMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000010">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF9">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL60559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="388" mass="43538" checksum="33C51E583050DBC5" modified="2017-06-07" version="1">MYFYGGGSYSDFFNMGEYSRMGYEFNRENISIFDTTLRDGEQTPGVSFNTDQKYKIAKMLYDAGVNIIEAGFPAVSNDEMKSIKKINHDMENICSLARCNRNDIDKVIESDSRIIHLFIATSDIHMKYKLKKTREQVFDSIMESIDYARSYGMRIIFSPEDATRTSMDFLKQIVSSIKVETINFPDTIGIMNPISMYYFINKIKSFTSTGISIHCHNDFGMATANTLAGLMAGANEAQVTVNGIGERAGNASLEEVVSSIYGFLNSYTDIKMEKLYSISKYVSAASGIIPQKNKAITGENAFSHEAGIHVQGIINNPKTYEAINPEIFGLNRRIVIGKHSGKAAIKYILENNGMHKTDDEIDNILQIVKKEGNKTIDDKFLLEVARNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6E2</accession>
    <name>A0A1V0N6E2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lysT</name>
        <name evidence="6" type="synonym">leuC</name>
        <name evidence="8" type="ORF">FAD_1837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143115.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6E2"/>
    <dbReference type="STRING" id="74969.FAD_1837"/>
    <dbReference type="GeneID" id="31677327"/>
    <dbReference type="KEGG" id="fai:FAD_1837"/>
    <dbReference type="OrthoDB" id="255at2157"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001614">
        <property type="entry name" value="PRK00402.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="7">
        <location>
            <begin position="7"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="7">
        <location>
            <begin position="283"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="413" mass="44643" checksum="BF41C86FC5851367" modified="2017-06-07" version="1">MSKTAVEKIFSEKSGTDSKSGDYIVANVDYVMANDITAPIAIDAFNELGMKPKSDKIIIIPDHFVPPKDINSAKQYKKSKDFALENGTWFYDIGHGGVCHQVMMEKGFAAPGRLIAGADSHTNTYGALSAISTGIGSTEAGVIFATGKMWFKIPETIKINLTGKPGKGVEGKDIILHVLSKIKNGGAAYKCMEFSGNIKYIDINERMTMANMTTEAGAKCSFFDTDEKTIEYLNRRNTGSYKIVKSDENADFSQTFNIDMNNIEPSIAIPNSPDNVRIASAIHEKIDQAYIGSCTNGRIEDIRKAAAILKGRKVNRNVRLMVVPASQEVYNQALMEGLINTIVEAGGYFSGTTCGACLGGYMGVLGPDEVCISSTNRNFIGRMGDKTSKVYLANPSIVASSAILGRIGTPEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6F6</accession>
    <name>A0A1V0N6F6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1827</name>
        <name evidence="7" type="ORF">HLB00_09770</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000435">
        <property type="protein sequence ID" value="NOL61104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143111.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6F6"/>
    <dbReference type="STRING" id="74969.FAD_1827"/>
    <dbReference type="GeneID" id="84218451"/>
    <dbReference type="KEGG" id="fai:FAD_1827"/>
    <dbReference type="OrthoDB" id="87732at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03230">
        <property type="entry name" value="ABC_DR_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050763">
        <property type="entry name" value="ABC_transporter_ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42711">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42711:SF5">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL61104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="298" mass="33610" checksum="51E7551B4A61D8E2" modified="2017-06-07" version="1">MIEILHLSKSFKNFKAVSDLNLEINNGQIMGLAGLNGAGKTTTIRAACGIIFPTSGTITVNNFDIVKEKIKASRNIGWVPELPNFEPDARPVPLLKYYAGFYGIKPDEAEKNAIEMMKQFDIYNYRNRKLKYYSQGMKKRFALIAAMIGNPDNYLFDETLNGLDPNGVKEVRDLIINLKKQGKSILLSSHILSELQNVADKIAIVKNGSVVKTLSRDDLMHLGTTGTKIHIKNPDAGMEKILSEFGEFTSDGTYYYIKNNGEVDVSELNRQLVIKNYRVDYISMENETLEDYFLNMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1B6</accession>
    <name>A0A1V0N1B6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">polB2</name>
        <name evidence="9" type="ORF">FAD_0002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1B6"/>
    <dbReference type="STRING" id="74969.FAD_0002"/>
    <dbReference type="KEGG" id="fai:FAD_0002"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05531">
        <property type="entry name" value="POLBc_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004416">
        <property type="entry name" value="PRK05761.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="8">
        <location>
            <begin position="291"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD83938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="639" mass="73909" checksum="A6AD4DC82E50AFBD" modified="2017-06-07" version="1">MDMEKIINATGSDVIELWIYRNGKIIKKYFNNRTWIFVSGEPYYLTMLEKSLDATNYIYRYTTMNDIYGLQNGIQIYLSPSKSSDMGSRIEESFGSRLKIYNADINNILRFMVSRGMEFYSLENPYEEDISLPAAVIEPVSTRGRIKYVAINGNIYSSNIYEETKRAIEENIIIIYRNYQNEFSILLDQMKKHGYYINARFYRERTFESYGRHSYMPGAVKIRDRICIDYDSFVYRESGISGLFELSRVSSLPVEIVSSITPGTVVSSIEEKEALKRKILVPFRKDDYEIAKNPAELFSADAGGIVFNPEPGIYSDVYEIDFSSMYPGIIVEYGISPESISGGNTAYLSQFLRGLLDRRLLYKYVNGRSDIYASRNKALKILLLNSFGYTGYKNAKFGRIDVHEKITGIGRKIIADSMRISEENGFTVLHGVVDSLWLSGNGDIDKTLKEIYDKTGIPIVLDSNYRWIAFMPQANGIGSANRYIGLRKDGTFKVRGIELRRRDSPPLVRKFQEQALDALNCSFDELPLKKEKLDDLKNRYMKLENFPIEDFRIEFGINRHIDDYKTRNSTYYLMKSLGREKMIYPGMVISGIVVDKKHNIIKSHSEFFDRKYYENLLKRSFKPFDFIISESANKIPDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1G5</accession>
    <name>A0A1V0N1G5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDGSH iron-sulfur domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0059</name>
        <name evidence="7" type="ORF">HLB00_07410</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887068.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1G5"/>
    <dbReference type="STRING" id="74969.FAD_0059"/>
    <dbReference type="GeneID" id="16025204"/>
    <dbReference type="KEGG" id="fai:FAD_0059"/>
    <dbReference type="OrthoDB" id="5781at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD83992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="69" mass="8045" checksum="8B0DFB45A304DA05" modified="2017-06-07" version="1">MSRIVLHERDKPYMVKVGDKEVHICACGLSENKPYCDGHHMKTVDEDGKLYVYDHNGDRLEVSSFYKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1I3</accession>
    <name>A0A1V0N1I3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl31e</name>
        <name evidence="6" type="ORF">FAD_0077</name>
        <name evidence="7" type="ORF">HLB00_07320</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141295.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1I3"/>
    <dbReference type="STRING" id="74969.FAD_0077"/>
    <dbReference type="GeneID" id="31675589"/>
    <dbReference type="KEGG" id="fai:FAD_0077"/>
    <dbReference type="OrthoDB" id="10127at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00410">
        <property type="entry name" value="Ribosomal_eL31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002258">
        <property type="entry name" value="PRK01192.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="90" mass="10276" checksum="C083ED0C9967AF34" modified="2017-06-07" version="1">MAENNELSTEELITVSLRGARSSSRRRRADTAIGIIKEAVSRYTKSEAEKIWIDNKVNELIWDRGREHIPTKISLKIIKLEDGTTEIILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1J2</accession>
    <name>A0A1V0N1J2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1J2"/>
    <dbReference type="STRING" id="74969.FAD_0087"/>
    <dbReference type="KEGG" id="fai:FAD_0087"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="112" mass="12581" checksum="0E8323CA7BB4C460" modified="2017-06-07" version="1">MQHTTCSGSVYIPYSLSYSLFKFKGKEINSKMIPEKMRINGINARGLLLTIKGKKSKKPALASPSTARVKRMANPDNIRRIPAYKLFELPFFPCILIPPPEFIAGTLFSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1K0</accession>
    <name>A0A1V0N1K0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Exosome complex exonuclease Rrp41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_0040</name>
        <name evidence="13" type="ORF">HLB00_02705</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'-&gt;5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000086">
        <property type="protein sequence ID" value="NOL59744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141261.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1K0"/>
    <dbReference type="STRING" id="74969.FAD_0040"/>
    <dbReference type="GeneID" id="84218531"/>
    <dbReference type="KEGG" id="fai:FAD_0040"/>
    <dbReference type="OrthoDB" id="24266at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016896">
        <property type="term" value="F:RNA exonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11366">
        <property type="entry name" value="RNase_PH_archRRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011807">
        <property type="entry name" value="Rrp41"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02065">
        <property type="entry name" value="ECX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="153"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD83975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL59744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="240" mass="26330" checksum="F876DF935689CF6D" modified="2017-06-07" version="1">MEGNIKLMREDGLRLDGRSLNEMRPIKIQTGVVDRADGSAFIEWGANKIIVAVYVREAYPKHAQNIDRAIVKARYNMSGYSVEERKRPGPDRRTMEISKVVSEALSSAIVLEKLPRAEIDVFIQVLEADAGTRIASLTASSVAVADAGVPMRDLVVGCTAGKADGKIVLDLSKDEDNFGQADIPMAILPRTGKVVLLQLDGDVTEEEFNEATSMMMDAMPRISELQRNALMSKYSIEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1M2</accession>
    <name>A0A1V0N1M2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaredoxin related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141358.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1M2"/>
    <dbReference type="STRING" id="74969.FAD_0120"/>
    <dbReference type="GeneID" id="84218610"/>
    <dbReference type="KEGG" id="fai:FAD_0120"/>
    <dbReference type="OrthoDB" id="35385at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02975">
        <property type="entry name" value="PfPDO_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02973">
        <property type="entry name" value="TRX_GRX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011903">
        <property type="entry name" value="TON_0319-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02187">
        <property type="entry name" value="PDO_seleno_TRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37170:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37170">
        <property type="entry name" value="GLUTAREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="4">
        <location>
            <begin position="137"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="220" mass="24825" checksum="D23EC4C66C341819" modified="2017-06-07" version="1">MSLIRDEDAKFLREDFDKKLKNTVDLVVFTSESSDCKYCKDTISLVDEVGALSDKINIVKYVYEKDKEMVEKYGVEKYPATIVARHDDKDGRIIYYGIPSGYEFGSLIEDLENVSVGEADVSKKAVDLISKIDKPITIKVYVTPTCQYCPKAVITAHKFALMNKNIKSEMIESLEFDKEASDAGVSAVPHIVINDDVTFPGAYPDDQFAEYVMEAYNHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1M6</accession>
    <name>A0A1V0N1M6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tryptophan synthase</fullName>
            <ecNumber evidence="4">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141340.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1M6"/>
    <dbReference type="STRING" id="74969.FAD_0105"/>
    <dbReference type="GeneID" id="31675617"/>
    <dbReference type="KEGG" id="fai:FAD_0105"/>
    <dbReference type="OrthoDB" id="25658at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406:SF1">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE ALPHA CHAIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE, ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="244" mass="28366" checksum="15D0BDC64EB7838A" modified="2017-06-07" version="1">MKNLIPYFTLGYPDNETLSHFLDLIPVDKINYIEFGFPSNDPRYDGPVIRKTHNVGNINFSDDFYKKYFDYFHKNHVKMYSLSYYSDIKARFDDFIDYLQKRNFSGIIIPDLIIDYYSEGKEIINKLNDRGFEYIPFFSPSTPDSIIKNVSSMTKSWIYYGLQPSTGIDIPYELDYTTERINELLPGREITYGFGIKTDDDIRNLMKNGGSGVAIGTYLIKMTEAGDENGFIDYINKMRGVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1P2</accession>
    <name>A0A1V0N1P2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="14" type="ORF">FAD_0106</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141341.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1P2"/>
    <dbReference type="STRING" id="74969.FAD_0106"/>
    <dbReference type="GeneID" id="31675618"/>
    <dbReference type="KEGG" id="fai:FAD_0106"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052684">
        <property type="term" value="F:L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006316">
        <property type="entry name" value="Trp_synth_b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009057">
        <property type="entry name" value="PRK12391.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01415">
        <property type="entry name" value="trpB_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF6">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500824">
        <property type="entry name" value="TrpB_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="72"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="417" mass="45585" checksum="C63F5D4EE913FF7D" modified="2017-06-07" version="1">MITAMNKEIIPDNWYNVVPDLPEPLAPPRDSKSDISSINLLNKILPKEVLKQEFTFKRYEKIPDEVMEAYEQIGRPTPLIRAKNLEKKLGYSGKIYYKYEGATATGSHKINTAIPQAYYAMKEGVKGVTTETGAGQWGSATALAASLYGLPSQIFMVKISFEQKPLRKTVMNLYNGNVVASPSTLTAYGRKILKEHPDTPGTLGIGISEAVEYALDNDYRYMVASVMNVSLTHQSVIGQETKKQLELIGEHADVLIGCVGGGSNFGGFTFPFIPDGDDTEIIATTANEVPKFSKGDYKYDLMDSAGILPQVRMYSLGADFVPPTIYAGGLRYHGASPSLSLLINKGRIKSDEVTEEEVKEALRTFANTQGIIAAPESGHAIASAIKYVKAHINEKKTIVVNVSGHGYLDLSIFGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1P3</accession>
    <name>A0A1V0N1P3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141365.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1P3"/>
    <dbReference type="STRING" id="74969.FAD_0127"/>
    <dbReference type="GeneID" id="31675639"/>
    <dbReference type="KEGG" id="fai:FAD_0127"/>
    <dbReference type="OrthoDB" id="64652at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050764">
        <property type="entry name" value="CbbQ/NirQ/NorQ/GpvN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42759:SF1">
        <property type="entry name" value="MAGNESIUM-CHELATASE SUBUNIT CHLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42759">
        <property type="entry name" value="MOXR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="493" mass="55487" checksum="824AE1809D4AF097" modified="2017-06-07" version="1">MGTYVNYTEYPDTSFIKIPSNPLDRVIGQEEAVRLALIAAKQRRNLLLVGPPGVGKSMIAQAMSFYISRPEEEIRVVHNPSYPERPFIEVRTIAEIENEKHEMNSIEGEIIEPKDAPDNVAQRLGYKCPHCGFYSSPTESVCPNCNNPKVVNNTQGPFNDVFNVIGVAFGVNNNNDRVTQTRKVGDKEQIVVYEKYGDKIRVLDEKTLERRRKLEKKSPSKVIVPIDRNPFVLATGASETELLGDVRHDPYGGHPQLGTMPYERIVAGSVHMAHEGVLFIDEITHLGNLQRFILTAMQERKFPIVGRNPQSAGASVKVDDVPTDFILVAACNIQDLQYILSPLRSRIVGNGYEVLMENSIPDTKENRMKYLQFIAQEINVDGKIPHMTMDAADLIINEGRRRALEEHKSNALTLKLRELGGLIRASGDMSIENGHKLIEKSDVKEALSLYVPVEEKIKKYYGSMNNALGEEATGSQRGEYYNYYNNSEDRSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1S6</accession>
    <name>A0A1V0N1S6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141352.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1S6"/>
    <dbReference type="STRING" id="74969.FAD_0114"/>
    <dbReference type="GeneID" id="31675626"/>
    <dbReference type="KEGG" id="fai:FAD_0114"/>
    <dbReference type="OrthoDB" id="56235at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="205" mass="24583" checksum="D12D4314A65CEFF0" modified="2017-06-07" version="1">MMHKINDRFYIFGGVKGLVRDGDELRKELLEKRPDIVFITIAPEQVDGMKEFLEDPFEMNLSDYEILYGINLSRYGEVMTPSPVYIEATRYCKENDIEMIGLDMDEGEYQIIYSKYVKTTDLLRHSMRKKKVSKYKFDAETPEEFVESWNNVVDLKSFKKVNAERKKYIIERIDSLQKEYSDRNIFCIVDYDYYKDVLNHFENRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1T4</accession>
    <name>A0A1V0N1T4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps6e</name>
        <name evidence="5" type="ORF">FAD_0136</name>
        <name evidence="6" type="ORF">HLB00_02905</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000095">
        <property type="protein sequence ID" value="NOL59784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887142.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1T4"/>
    <dbReference type="STRING" id="74969.FAD_0136"/>
    <dbReference type="GeneID" id="16025281"/>
    <dbReference type="KEGG" id="fai:FAD_0136"/>
    <dbReference type="OrthoDB" id="7793at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_eS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_eS6_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003294">
        <property type="entry name" value="PRK04290.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="129" mass="14218" checksum="35AC8325152326D8" modified="2017-06-07" version="1">MVVAVIADRNSGKTYKKDISEDVLGSLAGRKIGEEIDGIFFEMPGYKMKLTGGSANDGFPMKKDLSIMGKKRILITYNKGRKGKNGVRKRVTFRGNTIGSDISQLNLVITQYGTKPLDAKEETEEKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1X3</accession>
    <name>A0A1V0N1X3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141385.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1X3"/>
    <dbReference type="STRING" id="74969.FAD_0166"/>
    <dbReference type="GeneID" id="31675677"/>
    <dbReference type="KEGG" id="fai:FAD_0166"/>
    <dbReference type="OrthoDB" id="11182at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00604">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022851">
        <property type="entry name" value="SUI1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002096">
        <property type="entry name" value="PRK00939.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="99" mass="11182" checksum="8B6D3F6E5E1A2FFF" modified="2017-06-07" version="1">MKDKDFTGMPKELQPWEGFNRDSKLIKISVDKRRYGKLVTVIDGIDPKTENINDIAKTLKKKAASGGTVKDGRSIELQGDHRDVMKKELESMGFKVQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Y5</accession>
    <name>A0A1V0N1Y5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141418.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Y5"/>
    <dbReference type="STRING" id="74969.FAD_0223"/>
    <dbReference type="GeneID" id="31675732"/>
    <dbReference type="KEGG" id="fai:FAD_0223"/>
    <dbReference type="OrthoDB" id="372084at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01298">
        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004995">
        <property type="entry name" value="PRK06380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="51"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="416" mass="46096" checksum="218032B4C584A67B" modified="2017-06-07" version="1">MSILIRNGTIITENDNRDILHANILVDGNKITYIGSEELPHDNEIDATGKVILPGFINTHTHVGMSGFKGLLDDMVLSEFLDKTSKLDSQRTEEGIYNSSLLGMNEMINSGITSFVDLYYSEDVIEKAVEKTGMRGFLAWATLDQEFTTQKGDPVKNAESFIKKKHPDTVTPMAGIQGIYVSSDENYFRVKELSEKYNVMVHTHLSETRKEVYDFVKTHNERPVEHLGSIGFLSDKLIAAHCVWITLNEIKLLSKYNTSVSWNSISNAKLASGGIAPVPELLSNSVNISLGTDSSGSNNSLNMFEEMKYSAISINNDRWSADTVKSQQILDMATRNAGMALHAPIGIIKEGYLADLIVLDMEQYNTMPYTDSNIVNNIVFSANSGNVEQVMVNGKIIMKKDSSKTGVSFFSGLNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Z2</accession>
    <name>A0A1V0N1Z2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type I restriction-modification system methylation subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Z2"/>
    <dbReference type="STRING" id="74969.FAD_0248"/>
    <dbReference type="GeneID" id="16025414"/>
    <dbReference type="GeneID" id="31675756"/>
    <dbReference type="KEGG" id="fai:FAD_0248"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="N6 adenine-specific DNA methyltransferase N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="139" mass="16287" checksum="D33143C4CEF83AB2" modified="2017-06-07" version="1">MAVDCFRKITKNDLVKLMDNAADLVRTSVDYKYILILLFIKRLSDGWKEEVEDAMSKIMEEAGIDESEAGKRAVSNEFHNFMVPENALCNNIRKDREKLKENMSRGINEIAKENKELDEIVNRIDFIDLRLQSIFYYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N240</accession>
    <name>A0A1V0N240_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N240"/>
    <dbReference type="KEGG" id="fai:FAD_0253"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="106"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="256" mass="29795" checksum="E575B9F090BE6AD5" modified="2017-06-07" version="1">MFKHVNKILKKHCNKISRESKVEGIGIDSYSKKFNLSAHLSILAKGIIKKNDLTDIAYNNGISKSQLSKLNNKRPYTISEKVFYSLLNTFIKAHRYDIYHDYLDKLYSILAIDSTFIETMVNGSGIYQREKRRNGIKIHIAAKTNHYALPLKAIITPANVNDSKVFDDLLWHINEYMSGNTVLTFDLGYYSYDRLKELKENNINFVSRLRKNADYTVIKEETFNSKIVGFRNGLELRLVSPDIDNKRREYDLFHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N285</accession>
    <name>A0A1V0N285_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00270 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0283</name>
        <name evidence="3" type="ORF">HLB00_04375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000149">
        <property type="protein sequence ID" value="NOL60070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887305.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N285"/>
    <dbReference type="STRING" id="74969.FAD_0283"/>
    <dbReference type="GeneID" id="16025451"/>
    <dbReference type="KEGG" id="fai:FAD_0283"/>
    <dbReference type="OrthoDB" id="11138at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004451">
        <property type="entry name" value="MJ0586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058562">
        <property type="entry name" value="MJ0586_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00270">
        <property type="entry name" value="multiprotein bridging factor aMBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26602">
        <property type="entry name" value="HVO_2718_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="94"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="150" mass="17199" checksum="F12AF980D83279A2" modified="2017-06-07" version="1">MNCEMCGVSSDKLIKVKISGAILNVCPQCAKFGEPVEEKKLNKISENVTIKFPEKKINVVTYKKPFKKPVTTKKPVHRENVEELDVVEDYADLIKAKREEMNMTQDELAKKIFERKNVLSNIERGELLPDIATARKLEKVLNIKLLEKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2A1</accession>
    <name>A0A1V0N2A1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH15-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887380.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2A1"/>
    <dbReference type="STRING" id="74969.FAD_0361"/>
    <dbReference type="GeneID" id="16025526"/>
    <dbReference type="KEGG" id="fai:FAD_0361"/>
    <dbReference type="OrthoDB" id="36362at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF13">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="283"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="584"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="637" mass="73223" checksum="28717EAA1ADE4F12" modified="2017-06-07" version="1">MVRYIPLGNGKMLLTFDEDYRIVDFYFSETASGNHAAGHPFMYGVSVDDNFKWIDRNQIDSMDYYDHTMVGTVNYSSDGINFENKDFVDIYRNVYVRFITISNNSGVKKNVKLFFHQNFYIYGNDIGDTAAFYPEFNGILHYKEKRYFMASTIDQNGKSIDQYATGVKDVGNLKGTWKDAEDNELSMNPVSIGSVDSVLRHSFDIEAESKFYLYYYIIAGENYEDIEEISMDINLEYMEKLNRRTTNYWELWSSKVLPGLDSETNAIFRRSLFIVKSHSNSIGAIAASCDSDILKISHDGYYYMWPRDASIAAYALSIAGHTESGRKFFSMSTSLMSGKGYMYHKYNMDGSPASSWLPHIMNGKEIYPIQEDETALLIYVLWEYFKKYNDIGFTAPFYESIVIRAAEFMTGFVDADGLPRESFDLWEERYGIHAYTVSTTFAALKAASNFAGVFGDQALSRKYSDAADRMVNAFDQKFYSDEYRRYARAIINGKLDFTVDSALSSIAIFGMKNPTDSRVLSTMEAIMEKLWVNGSGGIARYENDNYMRIREDSNITGNPWIITTLWMARYYIRIGNLEKSWSLIEWVKSHRQKSGIFSEQINPYTGEPHSVSPLVWSNAEFIIAILEYSSAYRNQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2A9</accession>
    <name>A0A1V0N2A9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141547.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2A9"/>
    <dbReference type="STRING" id="74969.FAD_0371"/>
    <dbReference type="GeneID" id="84218869"/>
    <dbReference type="KEGG" id="fai:FAD_0371"/>
    <dbReference type="OrthoDB" id="55777at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="79" mass="9072" checksum="B7991FCAE908C31A" modified="2017-06-07" version="1">MNVDDQREVICGGDPDNYLKAYLKGLYFDLDDGQEIKVIFSSEKFPFNNEKFSEMVKAAKLKLLNYSGTEDTKTLIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2C9</accession>
    <name>A0A1V0N2C9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887352.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2C9"/>
    <dbReference type="STRING" id="74969.FAD_0333"/>
    <dbReference type="GeneID" id="16025499"/>
    <dbReference type="GeneID" id="31675842"/>
    <dbReference type="KEGG" id="fai:FAD_0333"/>
    <dbReference type="OrthoDB" id="38899at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051169">
        <property type="entry name" value="NADH-Q_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42913:SF3">
        <property type="entry name" value="64 KDA MITOCHONDRIAL NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42913">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="330" mass="35657" checksum="B6052C394CFBC897" modified="2017-06-07" version="1">MAGKIIVIGGGIAGISAKLRNRKSKLMDENPFMIMAPRIIDTLRGKSVDFPRIKRNLDYTGKATGIDLEEKTVNINGKNIAYEKLVIATGHSQKYDFINGSKYIHGFSGLEDALYLRNQLVNRKKIVIIGGGYLGVEVAGAMQNASITILEAGNRILAGLPLKFSDYATQLLEKNGVNIELGNPVDEVKKDCVVSGTKKFNSDITLFAGGFTGNLPEMKQELKTKNSRIVVNSFLQSVDYPDVYAAGDSMLVDNGGFIPMSAIIARSSGITAMENAMGGTKPFVPNNFANIIRVGDQYFGTIGNIFVHGSIAHIIKEAAVALSINHAREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2H6</accession>
    <name>A0A1V0N2H6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795611.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2H6"/>
    <dbReference type="STRING" id="74969.FAD_0386"/>
    <dbReference type="GeneID" id="31675894"/>
    <dbReference type="KEGG" id="fai:FAD_0386"/>
    <dbReference type="OrthoDB" id="5623at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="119"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="358" mass="38077" checksum="14F2E47CE33F563E" modified="2017-06-07" version="1">MANDKNYIPEPEKRAFLKGAGLSIAALLIGGISVERYVVPKDRGVPVMDNFPLAVLEDPSGSRITIKDVIEYAAASKSSTSTPMLVFDYPLQDEPNFLLVLKDVQVTTPDKSIVPTSGYSPISPSNKAPMDGIIYISYGGHNYSIMALSGICQHLGCVPPFLDYHPGQSIPFESKLIGYKSDAPGTPAQWPDYGLIYCKCHGSQYNPLWGGRNLYNNGPASSPANHSLPQIMLATDSYDSSGSGKIYAYGINSSNAVIRTHLQFPGGETYGSQVKSEDLTGGTAIRTASDSVASKTVSTLYTGNTTSSTPPKLSVSALGLNSNSSGVILYRTTVVSNEASNTQNWKGSFSGSTSTNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2J5</accession>
    <name>A0A1V0N2J5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps27ae</name>
        <name evidence="8" type="ORF">FAD_0457</name>
        <name evidence="9" type="ORF">HLB00_10020</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000442">
        <property type="protein sequence ID" value="NOL61153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887510.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2J5"/>
    <dbReference type="STRING" id="74969.FAD_0457"/>
    <dbReference type="GeneID" id="16025659"/>
    <dbReference type="KEGG" id="fai:FAD_0457"/>
    <dbReference type="OrthoDB" id="25142at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_eS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_eS31_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001669">
        <property type="entry name" value="PRK00432.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS31" evidence="7">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL61153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="51" mass="6047" checksum="372657A9FDFE72F2" modified="2017-06-07" version="1">MEKRELYAVEADKIVRKRRTCPRCGAGVFMAEHSDRYTCGKCKYTEFKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2K2</accession>
    <name>A0A1V0N2K2_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">MutT family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">FAD_0448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ARD84363.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="74969.FAD_0448"/>
    <dbReference type="GeneID" id="31675957"/>
    <dbReference type="KEGG" id="fai:FAD_0448"/>
    <dbReference type="OrthoDB" id="40462at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
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    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="141" mass="16224" checksum="CC021563E8E7819B" modified="2017-06-07" version="1">MKTYPKVAVGGVITLENKILLGKRRDEPDRYKWAIPGGKLELNETIEEGLKREMLEETGLTVEVESLLGISEIIRKDFHYVILDYKCRPVKGIEQAGSDALKLKYFDMESLDNSINESTMEFIKEMKKSTNFIHIIKKDID</sequence>
</entry>
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    <accession>A0A1V0N2M5</accession>
    <name>A0A1V0N2M5_9ARCH</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="1" type="ORF">FAD_0488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="74969.FAD_0488"/>
    <dbReference type="KEGG" id="fai:FAD_0488"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="150" mass="17418" checksum="D1D9FEEC85AED109" modified="2017-06-07" version="1">MSLIVRTLIRLSDHEMENELASKVYINVPKKVLEMYTIKVGCLLNGTIEQIKKFIDENESLNPQIRTGPKDYTQIIGSRVKMIFYSGQGEEAKDYLFFPKQIAIKLTSYAIFPNDYIVKLKLDFISCGWKHTKLYSQTSVNVDDTEQYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2P4</accession>
    <name>A0A1V0N2P4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha, alpha-trehalose-phosphate synthase (UDP-forming) related protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Trehalose-6-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0494</name>
        <name evidence="2" type="ORF">HLB00_03950</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000130">
        <property type="protein sequence ID" value="NOL59986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2P4"/>
    <dbReference type="STRING" id="74969.FAD_0494"/>
    <dbReference type="KEGG" id="fai:FAD_0494"/>
    <dbReference type="OrthoDB" id="79955at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="445" mass="51580" checksum="C68D286F3CB03AF3" modified="2017-06-07" version="1">MKKILVVTSRAPFSYRYAPGGDVRIYNVGGVATALSTMLKGTGGTWVCWGDGKNDMAHQEETTDGYKIARVFLNKTEKFGFYNSYSNRVLWPLFHYFRNNIHFDSTAFKYYYIANEKFAKKIKENITPDTIIWVHDYQLMMIPSILRTMDISNYIIFSWHIPWISPEFFSILPEAKFLAQSISKSNLVTFHTRLYEKNFFNTLEYHEIKVKNRLKTLAIPLGIDKNFFHLSKTMAIKPKKEKASIIFSIDRLDYTKGLLQRVKAIEKILSYRKDLIGKLVYLMNVTPSRTGIPEYDEIKEQLEMEVGRVNGLYSTTSWVPIIYIYRKISQKYLVSLYARSDIALITPLMDGLNLVSKEFVATTDKGVLILSKFAGAAEYMDGALIVNPNNINELASAIVRAMEMDGEEKMSRLKRMKKDVYVKNSNWWYKRILTTAERQWHVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2S1</accession>
    <name>A0A1V0N2S1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2S1"/>
    <dbReference type="STRING" id="74969.FAD_0530"/>
    <dbReference type="KEGG" id="fai:FAD_0530"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="184" mass="21299" checksum="0B7AA2DFFEFECD84" modified="2017-06-07" version="1">MDTLRNELYNNSRDIIKLLEERREIAGKIGECKVAGGLKIRNREREIEILKSLSYDHFTEFVLNLLFEFSINYEVLNRNSADSVKYSRILNGVKYIEYRSERDNLIFLLSRILNPGTVVLCDYHEISKILISAGHHIANAIEKPDLVIYMDGRENQEIIIKDGSMLISENFLASKANIYTVEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2S9</accession>
    <name>A0A1V0N2S9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141630.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2S9"/>
    <dbReference type="STRING" id="74969.FAD_0487"/>
    <dbReference type="GeneID" id="84217070"/>
    <dbReference type="KEGG" id="fai:FAD_0487"/>
    <dbReference type="OrthoDB" id="77269at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="134"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="365" mass="41174" checksum="27A529702076D192" modified="2017-06-07" version="1">MTETKIDHVSLLIRKAIEEESSGNKNEAAKTYKAAYKEVLEIASRSTGKIKQKRLEQAANLKKIYESIGGEAVEEDRISEGKKILGTLNIEPPEIPKVTFQDVAGLENVKTEIMSKIIYPMRYKELSQEYNIEFSGGMLLYGPPGTGKTFIVKAIANEVKANFINVNPSTLYSQWFGQFEKNISLLFRAAYLLSPSILFFDEIDTLVPKRSGSESDAARRGVSQLLTEVGGLTSQKDRNVFIIAATNNPWGIDEAIMRPGRFDVKIYIPPPDYESRKKIFQLKLSEVKHIDHIDYDELANKTERYSGADIEFICKKAVQNVFMEVIKTGNKIDVSTDDLLEVISQIRPSIDAGLLRKYQDYILNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2W7</accession>
    <name>A0A1V0N2W7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FeS oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887585.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2W7"/>
    <dbReference type="STRING" id="74969.FAD_0528"/>
    <dbReference type="GeneID" id="16025734"/>
    <dbReference type="GeneID" id="31676035"/>
    <dbReference type="KEGG" id="fai:FAD_0528"/>
    <dbReference type="OrthoDB" id="105445at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005909">
        <property type="entry name" value="RaSEA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01210">
        <property type="entry name" value="archaeosine biosynthesis radical SAM protein RaSEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004954">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Elp3/MiaA/NifB-like radical SAM core" evidence="7">
        <location>
            <begin position="43"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="351" mass="40665" checksum="ECC4CAC42BF2AB98" modified="2017-06-07" version="1">MVVRDYSLYIKSLMHENNRKNDVDKPVSIWKELDRLRGSPEKTMVCIFRTTGCAWYKFTACSMCGYFNDTSPEIVDENLMRQVDTLYDSLNDTKVLKIFTSGSFLDPNEVHPAVRDYFIDRMKDKVDKLLVESRTEYIKPETLQPFKKAKIDLRIAIGLESADDYIMKYSVNKGSTLKKFIDAAKILQQEKIELRTYLLFKPPFISEKMAIADIEKSVSIVAPYSADISINPMNIQKNTLVEKLWKKGLYRPPRLYSLAKILIDLGSQYPVLSYPTGGNKERGVHNDKYDGKLLDLIMQSSLDHDFGELSDYYNSLDLEDYRYDLDLEDKMFFQGDYMTLLKRLSGSSITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2X8</accession>
    <name>A0A1V0N2X8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940597.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2X8"/>
    <dbReference type="STRING" id="74969.FAD_0537"/>
    <dbReference type="GeneID" id="31676043"/>
    <dbReference type="KEGG" id="fai:FAD_0537"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="150" mass="17318" checksum="E256D1825060BE6E" modified="2017-06-07" version="1">MDSFDLRILKEISRDSRKPLKEIGKAIGIYSASAISRRIKEMQENNVIKGFKAEIDFGKLGYNFVTATFVRAKYGIEYHDIVAEKIMKIKGVIDVLFLLGDIDFYILCATKTKDDYVIILNELEKITEIERSDTHTVLNIYKYHDIANIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Y4</accession>
    <name>A0A1V0N2Y4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protoporphyrin IX magnesium chelatase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141712.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Y4"/>
    <dbReference type="STRING" id="74969.FAD_0586"/>
    <dbReference type="GeneID" id="31676090"/>
    <dbReference type="KEGG" id="fai:FAD_0586"/>
    <dbReference type="OrthoDB" id="25914at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="MAGNESIUM-CHELATASE SUBUNIT CHLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF9">
        <property type="entry name" value="MAGNESIUM-CHELATASE SUBUNIT CHLI-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="448"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="612" mass="68722" checksum="0F7AB58E48D53EB0" modified="2017-06-07" version="1">MRTYPFPFSAIVDNEDIKLGLIVNAIDSNIGGLLITGPKGIAKSTMVRALSSILPEVKAVKGCRFHCDPDGDLCDECLEAKKKGELKTENMKIRIINLPNSTTLDRVVGSLDISHAIKGESVLREGLIGEANRGILYIDEVNLLDDSIVDSILDSAASGINIVEREGVSYTHPARFILVGTMNPEEGELRPQLLDRFGISVEGKMPESPETLLDIADRVEEFDSDRESFIEKFRAPDREIQLKIVNARKLLPYVKIKREYRVFIADLVIKNSLSNRAMISTVKTAKAIAAYYGRTEVNEDDLKKALQFALNHRMKEKGKSRPDYNFNDPGNNGDNTDDNQEQDSASNQSTPTDQKNHEAGRNGEEKQQKQKENRESTVHNLEVNPGKKIETKKSGRSGRAKQFRHRGRKSGTYMDIRHSLLNTWSSGFRMINEKTIVMKDSYSKGSIPFIIAIDSSRSMNFSSRIEIAREFSDMLLKKLYIMRSRVALIKFAGERSEVLMNFSRNFTALKNIIDNISSGGKTPLYDALENIYKLSSYEKLKTVSLLVTDGRGNVFPGNARENLMEISKKIKPLSSMYIIDKNDNKFLPTYNGIISSYAGAKIINNIENIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Y9</accession>
    <name>A0A1V0N2Y9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphoglucomutase/phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_0602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141718.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Y9"/>
    <dbReference type="STRING" id="74969.FAD_0602"/>
    <dbReference type="GeneID" id="31676106"/>
    <dbReference type="KEGG" id="fai:FAD_0602"/>
    <dbReference type="OrthoDB" id="10363at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000001">
        <property type="entry name" value="Phosphoglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000003">
        <property type="entry name" value="Phosphoglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43771">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43771:SF1">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="9">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="154"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="257"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="8">
        <location>
            <begin position="372"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="446" mass="48732" checksum="4B2FBF41A686C7B9" modified="2017-06-07" version="1">MKQPELFGTNGIRGVPNEDLTTDLAMGIGKAIGTFFNGGKIAIAKDTRISGDMFMLAVASSIMSTGSDVIYVGELPTPGLQYYCKSKGIPGVMITASHNPPQYNGIKAIDKDGTEIDEESEIKIEDIYNGKLFKQASWEKIGTYNYDSTAIGLYMDSIVSMVDEKAIKERRLNVVIDTGNGASYYTSPTILAKLNCHVVSLNANPDGKFSSRNSEPKPENLVDLISVMKTGKFDLGIAHDGDADRCVFIDEKGNYIDGDKSLALIVKHTIQKGDIVVTPVSSSDALENICREKGAKLISTRVGAPIVARAMIDNNASIGGEENGGIIYGKHQFCRDGAMTMALMLNLLTHENKTVSSLLEEIPDYTMAKSSVARKKSWGEIKKLLMENFSGKKMDFTDGVKIFDEDGWTLIRPSGTEKIIRIFSESPSKSLAEEYNKTYMDFLANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Z2</accession>
    <name>A0A1V0N2Z2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0611</name>
        <name evidence="3" type="ORF">HLB00_09665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000431">
        <property type="protein sequence ID" value="NOL61084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887669.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Z2"/>
    <dbReference type="STRING" id="74969.FAD_0611"/>
    <dbReference type="GeneID" id="16025818"/>
    <dbReference type="KEGG" id="fai:FAD_0611"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL61084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="112" mass="12334" checksum="49189559D2BB2196" modified="2017-06-07" version="1">MDIKKYIRLKNDIETVIGIIIGFVFGAKFVAFLYPYLLHYSTAGITISQSVYAPIIALVTGIILFFGIRTLAYLISSMFLGAGIGIALFEFTGFNMLSTLILISHAMLTMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N311</accession>
    <name>A0A1V0N311_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887699.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N311"/>
    <dbReference type="GeneID" id="58788988"/>
    <dbReference type="KEGG" id="fai:FAD_0639"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="entry name" value="DsrEFH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="57" mass="6043" checksum="D589AACE011E6BDE" modified="2017-06-07" version="1">MIGLNLANHLNDETRVILFGESEKLAASGDADVTGLIKKLQEKGVIPIACSGYAENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3B5</accession>
    <name>A0A1V0N3B5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Monocarboxylic acid/H+ symporter MctP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141779.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3B5"/>
    <dbReference type="STRING" id="74969.FAD_0677"/>
    <dbReference type="GeneID" id="31676178"/>
    <dbReference type="KEGG" id="fai:FAD_0677"/>
    <dbReference type="OrthoDB" id="19182at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10322">
        <property type="entry name" value="SLC5sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF8">
        <property type="entry name" value="MONOCARBOXYLIC ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="505" mass="54418" checksum="F1612411D392DD97" modified="2017-06-07" version="1">MFTDLDLALFFAIIIIVLFAGYMAYFWRKPADMDAKGEWSLGGRRFGTVVMWFLLGGDLYTAYTLIAVPGAAATAGVGGGAFAMFAIAYGVMIYPIVYGTMPKLWNVSKRRGYITASDFVKDRFSSRSLAMLIALTGVLAELPYIALQITGIKYVLASLSLPITISLIIAFILVAGFTFVSGLRGPALTSILKDAIIWVAVIVIIIYIPIKLGGFGAIFGKAATISPHLLNISPVIDVGYTTLALGSALALFLYPHAITGTLGAKDSKTIRRNASLLPLYNVLLMFVAIVGIMAVVYFNKYPTVSSEALPRLVLDLFPASFTAFAFAAVVVGSIVPASIMALASANLLTRNVYLEYINPKASERTQTNLSRVLVIVVILAALAFSLVPAASGEIVYLQTIGGAFIMQTLPAVYLALFTRKLNKYPVAAGWAVGLTTTIVMLAQLDFKSSLYKDFHFVYIGVFALLLNLIVVGIGMAIMKGMNKVKDEGIIDNSEFEDIENMEEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3C4</accession>
    <name>A0A1V0N3C4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor biosynthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">moaB</name>
        <name evidence="2" type="ORF">FAD_0756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940627.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3C4"/>
    <dbReference type="STRING" id="74969.FAD_0756"/>
    <dbReference type="GeneID" id="84217376"/>
    <dbReference type="KEGG" id="fai:FAD_0756"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232:SF2">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="156" mass="18021" checksum="E3FC6A9D3C46F3CB" modified="2017-06-07" version="1">MHIHHEEHEYNLRYRIITVSSSRTRDTDISGDKMESYIGNNSSRSLVRDDEKEILSEFFLNYSDTDVFIYIGGTGVSRLDRTSMALRKIVDKEMPGFGELFRQKSGGIFPYLSDASLFIYREKIIFTLPGSADAQEIAYSIIKEIVPHLYHEITKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3E3</accession>
    <name>A0A1V0N3E3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0769</name>
        <name evidence="3" type="ORF">HLB00_06745</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000239">
        <property type="protein sequence ID" value="NOL60528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141944.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3E3"/>
    <dbReference type="GeneID" id="84217389"/>
    <dbReference type="KEGG" id="fai:FAD_0769"/>
    <dbReference type="OrthoDB" id="371687at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="194" mass="22508" checksum="525DF1F462E4C067" modified="2017-06-07" version="1">MDEKYREILEAFRNPTKMKIITLLVNNNKMTVTGMSKYIKTTRSNLYQVVSNLVSSGIVNEPEIRPKKNYVEKYYSLNDDYFAFHDENIDDEITGLPDSEYREILSSFFMAQSLNLEIIGKSIEAMTQKEIQNMRKHEKYTVFSYGTCSNSVFEKLSIAVKNELKKSVDDSGNEGMFLFLMLPSLFPDTLNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3G4</accession>
    <name>A0A1V0N3G4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="8">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cbiA</name>
        <name evidence="11" type="ORF">FAD_0799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cob(II)yrinate + 2 L-glutamine + 2 ATP + 2 H2O = cob(II)yrinate a,c diamide + 2 L-glutamate + 2 ADP + 2 phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887899.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3G4"/>
    <dbReference type="STRING" id="74969.FAD_0799"/>
    <dbReference type="GeneID" id="16026019"/>
    <dbReference type="KEGG" id="fai:FAD_0799"/>
    <dbReference type="OrthoDB" id="8896at2157"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05388">
        <property type="entry name" value="CobB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03130">
        <property type="entry name" value="GATase1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA/CobB_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002204">
        <property type="entry name" value="PRK01077.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="COBYRINATE A,C-DIAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873:SF1">
        <property type="entry name" value="COBYRINATE A,C-DIAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobQ/CobB/MinD/ParA nucleotide binding" evidence="9">
        <location>
            <begin position="6"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CobB/CobQ-like glutamine amidotransferase" evidence="10">
        <location>
            <begin position="250"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="8">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="453" mass="49909" checksum="9120C73DAAAD93AB" modified="2017-06-07" version="1">MGIKGLMIAAPSSGTGKTTVSIGIMKALTDMGLKVQPFKVGPDYIDTGFHYFASGNESHNLDSVMGSNNTVKEIYYHNSEGKDISIIEGVMGLFDGKAGNSLKGSSFEISRILGIPIVMVIDISASGRSAAAVVKGFRDFDKRALLKGVILNRAGSDYHCSMVKEAIETTTGIKVLGCIKRNNELKLGSRYLGLVTAAENQINDAYLKNLSSLIRKSIDLEQIVKISSTASKPSKYKPVIYNRREKEKCTIGIAYNKAFTFYYPENIELLKKFGAKIIYFDPVIDRKLPHMDGIYIGGGYPELYAGELSGNSALLAEIKEKIDDGMPVFAECGGYMYLSESINYGDAEYPMVGAIPARTHMEGLSLGYRKIYPAAPGEILKEGEKAMGHEFHYSRIVFNKSHSEAYKFENGKSEGYSSKNILSGYAHLYFPSNQNVPKRFVKQCVEYKNKTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3I5</accession>
    <name>A0A1V0N3I5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Benzoylformate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141912.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3I5"/>
    <dbReference type="STRING" id="74969.FAD_0751"/>
    <dbReference type="GeneID" id="31676254"/>
    <dbReference type="KEGG" id="fai:FAD_0751"/>
    <dbReference type="OrthoDB" id="6837at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="185"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="371"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="507" mass="55979" checksum="2C5AFBC34E4D49A5" modified="2017-06-07" version="1">MLGYTIFTKSLKNMKLTPVFGNPGTTEIPMLEGVSSDDYILTLHDSISVGMADGRAQLTRKPSFVNLHSILGVGNSMAFIYSAFVHRVPVIITAGEQDSRHIFYDPLLSGNIGDMISPYVKYKFEVNSANDIEKSIRRAYISSMTPPYSLSFLGFPMDIMGEEGKYSGLNMPYINSNVVDINAVKSIAEKINNSNNPVMVTGYELDMYGGIQYARDLAGKLGIPVFAEPFASRAPFHSGDKNYAGDLPPVAALINDKLSGYDLIIIVGGDINLYPYSMADLLEGKEIIKIGMDISGKIGDSYFMNPAAFLQSAIEYIKPRKPSVMPGKPAIDKNSQIQRVMLKISKNFGDYTISDESISASPFLRNIVGYKPDSYFIGKSGQIGWALPAAAGMATVKDNVLCVIGDGAFMYTSQTLWTIKNYNLPVKIIILDNHGYGILKKFSDVNYNESKKYLSFSIELKKVLDSFNIESRENDETMEDIEWLRNIKGPAALIVNVDKPYGYNLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3J4</accession>
    <name>A0A1V0N3J4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142020.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3J4"/>
    <dbReference type="STRING" id="74969.FAD_0823"/>
    <dbReference type="GeneID" id="31676324"/>
    <dbReference type="KEGG" id="fai:FAD_0823"/>
    <dbReference type="OrthoDB" id="359449at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="ASPARTATE-GLUTAMATE RACEMASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198">
        <property type="entry name" value="GLUTAMATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="Aspartate/glutamate racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="230" mass="25353" checksum="D8E6D7EC80B20D67" modified="2017-06-07" version="1">MEINIGIIGGMGPKATNQFLDRITELTEAANDQEHVRYILYSDPEIPDRIGAYFNGTKSPVDAINKGIDFLERNGITTIAIPCNTAHIWFSEFKAGVNLLNMVDLTVKAILDSGYKHPGFLATTATIKSRLYIKNLEEAGISAIIPEQEDTVMQAVKLVKLGEISRAKATLKPVVKELEDNGSDSIIMACTEIPVILNREDTELPLIDSDRILAEKIILSAGKRLKPYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3J6</accession>
    <name>A0A1V0N3J6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MutS-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141940.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3J6"/>
    <dbReference type="STRING" id="74969.FAD_0765"/>
    <dbReference type="GeneID" id="31676268"/>
    <dbReference type="KEGG" id="fai:FAD_0765"/>
    <dbReference type="OrthoDB" id="146065at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="4">
        <location>
            <begin position="323"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="496" mass="55918" checksum="71BDCF940751B896" modified="2017-06-07" version="1">MIKTYLLDSDGVDRYKEDLPWNSDSLIGDLGLNPILNAMSSGDQFLLKNSTTFILNSLNSIENIKYRQQVMQDFIEHRDYADKIYNITVSFITEAQKQFFWFSDNASLSMQISIGIIKLFSEKIAEIREIIGNMIGEAKSTGLKKFYSTVSDTFGPEYMATILENLERLQFKDGITMSVSLGMGNEGKDYILHKPDTGKKNIKQIVGDKIGQHYTYTLPERDISGGEEITDIRNRGVKKTAMVLKRSAQNCMEFFKELRCEIGFYISSINLLEHLKSRSGQYCFPEPQETESTALEFSGLYDLGLMLTTNSKIVPNNLDGDGKNLFVITGTNRGGKSTFLRSIGQAQLMMQAGMFVAAESYSGSVVSGIFTHFKHEEDKTMERGKFDDELSTMNLIADHIRRNSLILFNESFSSTNTREGAEVAMGITKALLESGIKIFFVSHLFEFASAMMEQNNESSVFLIAERADNGEHTYRIVEGSPSITGYGMDLYRKIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3N4</accession>
    <name>A0A1V0N3N4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein GlmU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142108.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3N4"/>
    <dbReference type="STRING" id="74969.FAD_0876"/>
    <dbReference type="GeneID" id="31676380"/>
    <dbReference type="KEGG" id="fai:FAD_0876"/>
    <dbReference type="OrthoDB" id="57352at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04189">
        <property type="entry name" value="G1P_TT_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005908">
        <property type="entry name" value="G1P_thy_trans_l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01208">
        <property type="entry name" value="rmlA_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42883">
        <property type="entry name" value="GLUCOSE-1-PHOSPHATE THYMIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42883:SF2">
        <property type="entry name" value="THYMIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="265"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="351" mass="39048" checksum="B377E734948445E1" modified="2017-06-07" version="1">MKGIILHGGAGTRLRPLTHTGPKQLIPIANKPMSQYVLEYLTDAGINDICMILGDISPEKVKDYYGDGSEFNCNIQYIDQGAPLGIANAISLTSNFVGNDKFVVILGDNLIEGKIKTFMDKFEKYNYDAFIVLTKSMHPKDFGVAEFRNNKLVNLVEKPENPPSNYVLTGIYFFTPLIFDYIKKLKPSWRNEYEITEAIQLLLKDNKNIGYDIIDGWWKDTGTVDDILAANMLILDRGRNIEERANVKGKVAIGKNVVLSDDSLIRGPAIIGDNTVIQDKTFIGPYTSIGDNCTIKKASIENSIIMDNSNIDTENTIVDSIIGENSVIMNANLLKPAGKRLLLGENSRIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3N8</accession>
    <name>A0A1V0N3N8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FAD_0824</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142022.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3N8"/>
    <dbReference type="STRING" id="74969.FAD_0824"/>
    <dbReference type="GeneID" id="31676325"/>
    <dbReference type="KEGG" id="fai:FAD_0824"/>
    <dbReference type="OrthoDB" id="56891at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD84724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="466" mass="52182" checksum="C324EB0A5CD1CD97" modified="2017-06-07" version="1">MLKQFPENGMDIQKIHETLDELGKNDIKNSRGRLFTYFYDPGIDELNKLQDIFLKFSNRNGMDYHAFPSTLKLENDVIAMMASLLHGKEGSAGTFTTGGTESIILAMKAARDRFFEKHHGVPEVILPVTAHPSFSKAVEYLGLKEIRLPVDEHYLADPELMRKAITENTAMIVGSAPSFPYGTIDPVKELSDIALENNLWLHVDACVGGMILPFLKRLGHNVQDFDFTLPGVSSISVDLHKYGFTPKGSSVIMYKNEELRKHQIYVNAKWPGYPMSNAGMQATKSAGPLAGTWAIMNYLGYKGYTDLASKTLSAYKTLTKGIENIGYEITGKPDATIFAFQDNNNSIFTTGVNMIEKGWYPQIQPSNLELGLPSTIHLNVCPVHVEVADEFLSDLENIHKNAGKDSGSRELAVESRDKAVDYLVNLIEQNPEKKTLFFHMIYNLDPEKGEEIFRKITDMDFHAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3P8</accession>
    <name>A0A1V0N3P8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3P8"/>
    <dbReference type="STRING" id="74969.FAD_0879"/>
    <dbReference type="KEGG" id="fai:FAD_0879"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045384">
        <property type="entry name" value="DUF6527"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20137">
        <property type="entry name" value="BubE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="132" mass="15662" checksum="D291BB1BED1EC51F" modified="2017-06-07" version="1">MSIMKKIRIIRPEFVEFIPDDIKEGVLYISIRYNTATHRCPSGCGEIVVTPITPTDWTLIWNGESVSLYPSIGNWSLPCESHYWIRENRIVWARKWNIQEIEFAKDIDDSNKAYYFKHKKKNLDKVDKNRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Q7</accession>
    <name>A0A1V0N3Q7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142056.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Q7"/>
    <dbReference type="GeneID" id="31676344"/>
    <dbReference type="KEGG" id="fai:FAD_0844"/>
    <dbReference type="OrthoDB" id="29061at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="405" mass="43558" checksum="1BBFD1E25430DFC3" modified="2017-06-07" version="1">MSLTAREIGIKSRLGLFVIFVAGALPALIVDFDGSAYTYAAPYIISNVHLPLYFLGILISGYAAGIAIFSLIGGFLFDRFSPKITVTVSILIFSIFTIATGYSTTAIEVLLSRLIVGFGVGMFQASSIGVLGDANPEFRGSGTMLWGVLAGVGTTAAPYIFLPFLPDYHLPFLISGVLGFIVAIIFFMIIPSVFKKETKAKNPLKLALNKYTIFPILAMFFFGFTLLNMLGYYSEFLLTIIKFSSAEGAVLISMLGVGGIIFGLPAGFASDKIGRKPILVIGILLVFIAIVTITYAPKNYIAFIFLTIMFGTGWSIFSVLTPASGQDMVKDEAVGSASGAILMFFNIGGIIGPLLLASYITVTTFRSGMLYFMIIPAAIALIITLFMKFPKSTKEVAKEQIKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3R2</accession>
    <name>A0A1V0N3R2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142121.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3R2"/>
    <dbReference type="GeneID" id="31676389"/>
    <dbReference type="KEGG" id="fai:FAD_0884"/>
    <dbReference type="OrthoDB" id="57982at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="225" mass="26418" checksum="B5919506FA0616CD" modified="2017-06-07" version="1">MKDKPKYYNCLEQIKSGIYLNNTRGEIGRKERDFEADELLIKYFNNCDFASIESDIILTVFEDTTTTLIQAIESYRYGQFDSSMVMVRSAIDAATYASITMEPVYDHNLNRLISINPIDGITSYKKYNKVDRRIKEIIDKGFLTNNETDELFKIRDEGNFSAHYFKINKEHFNDIIKIYGTKHELPEDLPRQFTTEKDNQSSLLRAFEIITTLQNNYLKFYKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3U5</accession>
    <name>A0A1V0N3U5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143151.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3U5"/>
    <dbReference type="STRING" id="74969.FAD_0862"/>
    <dbReference type="GeneID" id="31676362"/>
    <dbReference type="KEGG" id="fai:FAD_0862"/>
    <dbReference type="OrthoDB" id="374875at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052546">
        <property type="entry name" value="Transposase_8_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33609">
        <property type="entry name" value="LOW CALCIUM RESPONSE LOCUS PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33609:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="89" mass="10300" checksum="228467D3D9A8253B" modified="2017-06-07" version="1">MEKFTADEKAAIVMESFTANNIAELCRRRGVSVSNFYKWRDKFIESGKQGFYGSGVNNGYEKEIEKLKRLVGDQALVIDELKKNYRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3V9</accession>
    <name>A0A1V0N3V9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Cas10d (Csc3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cas10</name>
        <name evidence="1" type="ORF">FAD_0944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3V9"/>
    <dbReference type="STRING" id="74969.FAD_0944"/>
    <dbReference type="KEGG" id="fai:FAD_0944"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="884" mass="101928" checksum="B3B85D1A031751BF" modified="2017-06-07" version="1">MEWATNSIFSPLWMDPDFMKCAKGGNEKDSYANKSDMFYLIHIFSGTAMALKVFDYKYLNKNPEEEIENITKKLKRSIFGYLFHDFNKLSNYEENKYMRDKSELDTQLEKFSSIMAELELSKDDVYFIAFATEKGTQYISNSIDVSLEHNLQFESSFSRLADTLSSIFSDNNDNIKDIYFNNAPCIPKSRIQKINITNTTFITTSSFLKKIIIQNIEKNNGFYLWSTLNSIYYVRDTAISLDVKILANELTREIGIKAHLENGITLTDRKIDISSSNIGSINKEILLKFVADGTKFKQVLHLENIPLRDEMRHNAEIYSDHIANLESFSINFHKDMPENKKRTPRSVREYVEAETYYDSNSIDMEESGKIQERLHAFYIRYVQLKTTLKSEQAYMIRNKLDDILDDNISILENFLPKNNKSKSAFLIPLLLAGKENNKINWDNIESDILTDINAGSKSENNEEIVSEIINIILNVNNINLPAVPDKISMSMISGYPAKTAAHIENLFGLGTNSFNNRLPTSGISNGKIDPYTIYEFSLRHVLAPKVGAKYSSAILFLSFPGAIPFMNMDKFLKLSSNVESDLKVNNIVLTLDDANAKLDNFLFDSTYYIYLNDPKKDSDILRYLVNVIEIALRSKLHALLSFSNNIFYNSWNETILVELESSLLNGMRWNKIRCNNISLIKKEIYFFLNAARKNNKFDYDNASVIIKDYLRDNFSLSYYVHGQFFNGYHNILSGKDKIDLMRKLVYGNKGDKMEKIEKLGETAAELRRLPRKSSGSERGWMVRDSLEVMEKMKAETKINELSDLKDFVSGYMSKNLERLLKRDRPDLDLKPHSENILQFTDLLFSLINEEFKGKIPAGITRSYLVDAFEIEYELASDMKRNKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3W5</accession>
    <name>A0A1V0N3W5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951114.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3W5"/>
    <dbReference type="GeneID" id="31676388"/>
    <dbReference type="KEGG" id="fai:FAD_0883"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="209" mass="24691" checksum="89D0CE46AB925237" modified="2017-06-07" version="1">MKYVKQQGRQGKGRKLGIFLNENIKDKIIFYDMETITIGANWAEGLSVENFPIFAITKNKKILFFLPPPKSSTYKKSDNIILLPDYTIHFRINKESHFFQYSISQNLKINYDIDYIYHTYFIAPEKDEKYLIMSLLMFMLLFPFTELLFLILHLNSFSYLFDILEVEVVLILTTSFAQLRTKFINYRIWTAISIILMGILFVTGLVYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Y4</accession>
    <name>A0A1V0N3Y4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142163.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Y4"/>
    <dbReference type="STRING" id="74969.FAD_0907"/>
    <dbReference type="GeneID" id="31676410"/>
    <dbReference type="KEGG" id="fai:FAD_0907"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="183"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="352" mass="40465" checksum="BD78437CA23763F8" modified="2017-06-07" version="1">MKVKVINSSQKFSSIWLYSRNLCKVDNKNVSVLDAYNEFNGINLMKREFQIGVDSCLGGLFLRQELDDKDYDILHYANQTISPVKTKKVQIVTVHDNPYTFLQSGIYSSYTSTEKNFKKLIKYNIVLIKNRFLKRNMDRYKEFENVLTNSNYVGKSLREYGFTGNIKTIYLPVSPYFEKLQHKHEIRKELGLPDNRILLLSVSNNATRKNLALIEKAMKILPDRFSLVRVGTPIGNSITFQNVSNENLNKIYNACDVLLMPSIEEGLGLPIVEGFATGIPIVASDIEVFHEIGKDAVEYINPLEMQSLISGINNALENKDKMISKADKIVPQFSFQLFKEKMLDYYKKCYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N489</accession>
    <name>A0A1V0N489_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142393.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N489"/>
    <dbReference type="STRING" id="74969.FAD_1036"/>
    <dbReference type="GeneID" id="84217633"/>
    <dbReference type="KEGG" id="fai:FAD_1036"/>
    <dbReference type="OrthoDB" id="55814at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07952">
        <property type="entry name" value="ED_3B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="1">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="257" mass="29449" checksum="2D27852423CC1232" modified="2017-06-07" version="1">MVLNNIYMIPHGDELIDIPDEDSRKLSNALKELTENDSSDVLVILSPHGVNLSKNIAVVNTEYFKADTQLKNTYLDFKVQNERKLTEDIIKSTRDTTEELRFITYSGDISVFPLDFGSSIPLSFFKQRNIVLIGQSRINDRGRLINFGKSLYNTVQAYNKKVSIIISADQAHTHSDKGPYGYSQNAEKYENTVKHCFETGSFEALYKIEQEIIDTGKPDSFWNLMVMYGILQASGRKMRLDYHYVEIYFGMMLAHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4B2</accession>
    <name>A0A1V0N4B2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenosine kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Adenosine monophosphate-protein transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1103</name>
        <name evidence="2" type="ORF">HLB00_09095</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000372">
        <property type="protein sequence ID" value="NOL60974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886207.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4B2"/>
    <dbReference type="GeneID" id="16024332"/>
    <dbReference type="KEGG" id="fai:FAD_1103"/>
    <dbReference type="OrthoDB" id="371841at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1520.10">
        <property type="entry name" value="Ta1353-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007153">
        <property type="entry name" value="Adenosine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036902">
        <property type="entry name" value="Ta1353-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155">
        <property type="entry name" value="BLL5354 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155:SF1">
        <property type="entry name" value="BLL5354 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04008">
        <property type="entry name" value="Adenosine_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103165">
        <property type="entry name" value="Ta1353-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="160" mass="17774" checksum="3313BC548C8FE316" modified="2017-06-07" version="1">MEIVAVEINKPEDVNIILGYSHFIKTVEDMNEIIKTTIPGCEYAIVFSEASGDKLIRYEGNNKELIDCGIENIKKISAGHTFMILLRNAFPINILPQLKMTQELGAIFAATANPIKVILAKTENTNAVIGVADGYSPVGVETDKDKEKRRKFLRDIGYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4C7</accession>
    <name>A0A1V0N4C7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1116</name>
        <name evidence="4" type="ORF">HLB00_00380</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000011">
        <property type="protein sequence ID" value="NOL59295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886221.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4C7"/>
    <dbReference type="STRING" id="74969.FAD_1116"/>
    <dbReference type="GeneID" id="16024346"/>
    <dbReference type="KEGG" id="fai:FAD_1116"/>
    <dbReference type="OrthoDB" id="168391at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF287">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="412" mass="47059" checksum="D21A72654C4F3A42" modified="2017-06-07" version="1">MKYDVVVIGAGITGLSSAYHLKKKDSSLKILVVDKFKTFSQGNTAKSAAAFRDFFTLRENQVMAQTAINFYKHLQNDMDVDLGMKFTGYLFLFDHEKARDFISKYPHSRFVDEDLSEIFNLNIDKDTREVMGIDSIKSAVIDENAGIIEPDLLSKWYYDRLLEMGVNFMFNTFVKKLVLAPDTSLNYPGEPFNWQKSEIKYAETDKGILESDFYVLCTDVWTTALLNPVGIDSHLRPKKRQIFQITSPGIQKLIGKNIFNDSGVFPFTIFPTGVYMRPYPQANSFWTSLADELNRDFSFTENPEPEPDFYTYNIKPILDNYFPASEDSRITASWAGYYSYNTIDFMPYIFNEINLIVVSGSTGGGIMKGDSIGRIVAARYDHKNTTTLYGGKKINNTYTGRYRSTKIEDMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4D1</accession>
    <name>A0A1V0N4D1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylisocitrate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142491.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4D1"/>
    <dbReference type="STRING" id="74969.FAD_1122"/>
    <dbReference type="GeneID" id="31676619"/>
    <dbReference type="KEGG" id="fai:FAD_1122"/>
    <dbReference type="OrthoDB" id="43639at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="260"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="429" mass="47851" checksum="145616ADD12DDAB4" modified="2017-06-07" version="1">MAIENKLAEFITGVSYNSLGEDVKHEVKRRFIDALGVAYSSMDSPAALKIKKMIGLYPGNAKIIGMGTSSPDYSAFLNSLFIRYMDFNDTYLSLEPLHPSDMFGPLVSLSSIFNKTGKDLITAAAVGYEIGTRLCDSTSLRAKGYDHVNFTEIAMAAALSRLLEFDESQTINAISIALVPHVALRQPRVGGLTMWKAGAAANSARNSVFGTLATLYGFTSPTEPLSGKMGFKNIVAPDMDFSKLEGSKVNGIMRTYVKKYPVEYHAMAAVEASLKLVNDIDLHHTDSIEVYTYEAAVSILADKEKWHPENKETADHSLPFIIASTLVNKDFWVNNYNDIRNKQISELMGKIHVTELKEFTEQYPDKLPIRLEAKCNGKKIESEIEIPRGHYKNPMDDREIESKFVRLTGITDSLKDMWTMEDREVSELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4F3</accession>
    <name>A0A1V0N4F3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142479.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4F3"/>
    <dbReference type="STRING" id="74969.FAD_1107"/>
    <dbReference type="GeneID" id="31676605"/>
    <dbReference type="KEGG" id="fai:FAD_1107"/>
    <dbReference type="OrthoDB" id="110773at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053172">
        <property type="entry name" value="Tn903_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053520">
        <property type="entry name" value="Transposase_Tn903"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033579">
        <property type="entry name" value="transpos_IS5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631:SF3">
        <property type="entry name" value="ISSOD12 TRANSPOSASE TNPA_ISSOD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="129"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="308" mass="36252" checksum="935F3B069F5009E4" modified="2017-06-07" version="1">MTPQINNKINRSIKRYWIGSNRRWEKYNESLADRIEYLADLSFIRDYDSLLEENNNGKIGHPYKVPDALIMYLARLRSIFNVPFRSLEGMLRSLAIIANIKSISYSEIFRRIRRIKPDLNSNINSKLDCIIDSTGSKITIRGDYLRHKWHRKRNGWLKLHVIISLKDVTVLSFTITDEHTHDSKAARKLLSKMKNNILRIFGDRGYDSKYIYNMFGYNAIIPPRKNASTKSRGSSTRARIVRYIKKNSMEQLKENNSYGKRWLVEIYFSGLKRVMSEVIKAKKIEYIVQELALKVVNYNIMRGMTHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4G2</accession>
    <name>A0A1V0N4G2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylisocitrate lyase</fullName>
            <ecNumber evidence="6">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4G2"/>
    <dbReference type="STRING" id="74969.FAD_1121"/>
    <dbReference type="KEGG" id="fai:FAD_1121"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012695">
        <property type="entry name" value="PrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02317">
        <property type="entry name" value="prpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF5">
        <property type="entry name" value="CARBOXYVINYL-CARBOXYPHOSPHONATE PHOSPHORYLMUTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="264" mass="29395" checksum="FECD11B2F915DC14" modified="2017-06-07" version="1">MLAERKGFKAVYLSGGGLTASMGLPDLGVITLTELTNMVRGIHEITDIPIIVDADTGFGETLSVYRTVKLLEEAGASAIQIEDQVSPKRCGHLNGKEVISRDNMVEKIRAANAARKNALIIARTDSRAVTGMEDALSRAKTYIKEGADIIFPEALTDRTEFKYFADNTDFPLLANMTEFGKTPFIKAGEFQEMGYRIVIFPVTLFRIAAKAMDLALDALKKDGNQEKIIDQMMTRKEQYEVINYDFYQDFDKNISDKPSKANDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4H2</accession>
    <name>A0A1V0N4H2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142552.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4H2"/>
    <dbReference type="STRING" id="74969.FAD_1164"/>
    <dbReference type="GeneID" id="31676662"/>
    <dbReference type="KEGG" id="fai:FAD_1164"/>
    <dbReference type="OrthoDB" id="43333at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09836">
        <property type="entry name" value="CBS_pair_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="141" mass="15246" checksum="AE7F8C114D83A2A4" modified="2017-06-07" version="1">MTLEISNIMQKHPAYIDGASTIYDGAKKMTEENKGSLLLGSAESMKGIVTERDIIKAIAGGKSLTAPVGDVATKENLIVVHEDDSITKAAVLMSKHNIRHLIVKSENGAVTGVLSTRDLMRESYTLKELANVKNSDWFGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4K9</accession>
    <name>A0A1V0N4K9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_1160</name>
        <name evidence="12" type="ORF">HLB00_05730</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be a 3Fe-4S cluster-containing protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">To ferredoxins from P.putida and C.tartarivorum, ferredoxin I from A.vinelandii, ferredoxin II from D.desulfuricans.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="95" mass="11017" checksum="147799762AA11785" modified="2017-06-07" version="1">MRTEEKLYTLRYKKDDKSHLGIKDVNTCLECTERFGEPQPCVSICPANVFTWENNRIIIGYENCVECGASRIACPYDNIDWNYPRFGKGIALRYA</sequence>
</entry>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
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            <end position="234"/>
        </location>
    </feature>
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        </source>
    </evidence>
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                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Y</strain>
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    <dbReference type="STRING" id="74969.FAD_1204"/>
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            <dbReference type="EMBL" id="ARD85077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="86" mass="10184" checksum="69F98492E6FD6AB6" modified="2017-06-07" version="1">MPVDKQQFESSGTNSIGATVLEFLEENTVNAYTLKEIDEHIAKNHDNLIIHMELTFLVWSDKIEYRDIYNQDGKLVRYFRFKESKK</sequence>
</entry>
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    </gene>
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        <lineage>
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                <person name="Tatusov R.L."/>
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                <person name="Golyshin P.N."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="225" mass="24565" checksum="2C1EBE6B52F53BFE" modified="2017-06-07" version="1">MKVFLDSSDINEIREISDYGFIDGVTTDPVSIAREVSKGSTTEQVITSIIKAVNGEVHIQVVSQDYDSIMSQAFKIHSLGMNVIVNIPATFTGIKAMLKLNEKKVKCSALSVYNTVQAIMAAQNYPEYVSIKTGKIKNTAEDGMELAYNVNQTFKNCGFDAKVLVGGISKLEDITRAGIMGAGAISVTYPLLKQVEGDINMGTEIAEQMEAWNKIAESSRTFFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4R4</accession>
    <name>A0A1V0N4R4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1230</name>
        <name evidence="3" type="ORF">HLB00_07035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000254">
        <property type="protein sequence ID" value="NOL60581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142641.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4R4"/>
    <dbReference type="GeneID" id="31676728"/>
    <dbReference type="KEGG" id="fai:FAD_1230"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="260" mass="29959" checksum="C8162430CFE2EDF3" modified="2017-06-07" version="1">MVSAKKQLEDFQEQLQTMHANLEAVQAENQELTSRINELNNKIAAGLKREEDLKNQNESLKSSLLDTNEALESFKKQNEDIQHELADKNTMLESTAEKTQTMEEEIENLKIENSKIQEDMENTTASSQKISSELKEKIDRLQKYISELESKDSQSQKAINELSSTGREQSAQIKSLQKEIKDKNSLIEELDLHNYELNHDLKTSEIKEKSLRETMELLNAANDNFKGLLEKYRFLLENNITVKKRSMSTKKPVKPKKTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4R8</accession>
    <name>A0A1V0N4R8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1225</name>
        <name evidence="10" type="ORF">HLB00_07080</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000257">
        <property type="protein sequence ID" value="NOL60590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142633.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4R8"/>
    <dbReference type="STRING" id="74969.FAD_1225"/>
    <dbReference type="GeneID" id="31676722"/>
    <dbReference type="KEGG" id="fai:FAD_1225"/>
    <dbReference type="OrthoDB" id="27922at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF1">
        <property type="entry name" value="NAD(P)H SULFUR OXIDOREDUCTASE (COA-DEPENDENT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="320"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL60590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="438" mass="47695" checksum="52DF9E4790C0403A" modified="2017-06-07" version="1">MNIVVIGGGAAGMSAASKARRMDKTARITVIEQTGYVSYAECGMPYYLSGYFEDSGELLHYPLSEFTEHRNLEVITGTKVEYINPGEKYVFAGNKKFPYDKLVIATGAEPRIPDEFKGYAYALRNMDDAIGIKEKIKGLNNVTIIGAGVLGTELFSLLSHKFKVKLISKHEYVLPHMDSDMGNILTSIVNESGNEIEYNSIPSAISGTPGNYQVTTGNGPFNTQIVIFATGIKPSTELAEKAGLELTADGLIKVNDFLQTSNSDIYAAGDNVATKNIVTGSYGYYPLAQIANKMGRTIGINMFGNSRVFPGALGTTIINVFGYQVGYTGINEATAKKTGIDYGSVYIKAKSKSNYLHGSNIFLKIIYNKKTEEIMGGQIIGKDNAAWRLNVIATAISGHMNLYDLLYNDLGYEPEYGPVWDPIIISASLALDKENKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Y1</accession>
    <name>A0A1V0N4Y1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="4">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FAD_1287</name>
        <name evidence="18" type="ORF">HLB00_03300</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Berkeley</strain>
            <strain evidence="19">Y</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000103">
        <property type="protein sequence ID" value="NOL59860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142760.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Y1"/>
    <dbReference type="STRING" id="74969.FAD_1287"/>
    <dbReference type="GeneID" id="84217882"/>
    <dbReference type="KEGG" id="fai:FAD_1287"/>
    <dbReference type="OrthoDB" id="23624at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005036">
        <property type="entry name" value="PRK06451.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504:SF1">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="18"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="313"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="14">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="14">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-succinyllysine" evidence="15">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-succinyllysine" evidence="15">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="15">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604439-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604439-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR604439-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR604439-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ARD85155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="NOL59860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="392" mass="43860" checksum="0DA65C896DCAF40A" modified="2017-06-07" version="1">MAKITFENGKWKVPDNPTILYTDGDGIGPEIMDVTRKVVDAAVKKAYKNKKIEWKEILVGDKALKEKNDRFPEESQEAIKQYRVLLKSPLGTPIGTGFKSINVRIRVMLDLYSNIRPVSFMKGLESPLKHPENVNLTIFRENTDDLYTGIEYKYDSKEAAEIRKFFKDKLQVDISDDSGIGIKPMSKYKTQRITRAAAKFAIENNKKKITIMHKGNVMKYTEGAFREWAYETLQNEFGNYTSTDDSSKILVNDMIADNMFQQIITRPENYEVILAPNIDGDYISDAAGALIGNIGTLGGANVGDDAGMFEAVHGTAPKYAGQNVADPLGLIRGAQLMIKYLNWHEAFDVIEKAIGEAIETKKVTKDLAKFFDVPAMGTKEFGDSLVKIIDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Y9</accession>
    <name>A0A1V0N4Y9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142791.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Y9"/>
    <dbReference type="STRING" id="74969.FAD_1315"/>
    <dbReference type="GeneID" id="31676808"/>
    <dbReference type="KEGG" id="fai:FAD_1315"/>
    <dbReference type="OrthoDB" id="1018at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="196" mass="22681" checksum="1EB07F9B21C7F9D5" modified="2017-06-07" version="1">MKDYYLEGEEKFGFFTTSFYNRVAWRLLKKLYSFALDEMKDMEPSSILDIGAGPGKLSLMVSQKFPHAEFFAIDPSLNMVKAEQKNFEKAGIKASCKPGSSRDIPFDNKFDLIYTTLSFHHWQDRDSNIKYILSKLADNGTFLIIEFMQEYYKSSMSLHGKHSISKKYAESLNFDGYEREINTSGEFISLKFKKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N530</accession>
    <name>A0A1V0N530_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142872.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N530"/>
    <dbReference type="STRING" id="74969.FAD_1387"/>
    <dbReference type="GeneID" id="31676879"/>
    <dbReference type="KEGG" id="fai:FAD_1387"/>
    <dbReference type="OrthoDB" id="358920at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="320" mass="37050" checksum="ED0E0C76C16FCA1B" modified="2017-06-07" version="1">MNNKYDIDNGLHVVIGATGAYGYAVTKILLKNKINVRAIVRNEEKALKLFPKDVDIVKSDIFNMDKIIKDLKGASVIYIANNFPYKNWQNYYISTENILKGAETSNSTVVFPGNVYGYGKFDYLPVNEEHPLNANGKKGILRNNIEKLLFEYYKKDKIGLVIPRFADFYGPNVTNDLYGGMFIKAMKNKKAIWPVNPDIPHNFTYIDDAAKATLLLLRNINSYGKVYHVSGDIITAREFINKIYNRLNLKIKLKVISKLDLKLLAHFSSNINEIMELIYEYSEPYILDDRKFLNEYPEFRHTTYDDGINNTINWFKNEYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N541</accession>
    <name>A0A1V0N541_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase mutator family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0837</name>
        <name evidence="5" type="ORF">FAD_1392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142046.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N541"/>
    <dbReference type="STRING" id="74969.FAD_0837"/>
    <dbReference type="GeneID" id="31676883"/>
    <dbReference type="KEGG" id="fai:FAD_0837"/>
    <dbReference type="KEGG" id="fai:FAD_1392"/>
    <dbReference type="OrthoDB" id="56934at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033543">
        <property type="entry name" value="transpos_IS256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217:SF8">
        <property type="entry name" value="MUTATOR FAMILY TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="386" mass="45740" checksum="E65B0FD2E2E150AE" modified="2017-06-07" version="1">MENTDINISDIENIDIDKLLRNAIKERIEKLMEIELNAYLENNPGIKNGKYKRDLKTKYGEIKQLNIPRDRESNFHTQVIEPYNRSIGMEDLIVSMYSNGISTRRIAGIMEDILGNKYSKSTVSRITDLTIEEVYKFINRPLDKRYIAVFLDGLFFYLRRGNVDKEPVIFALGIKETGEYELLGFYLTVKESHNTYKDVLEDLYNRGLKEPLLIVADGIKNLDEEVMEIYPRSEFQLCTIHYARGLKSNVREKDIDEITIDANKMFKCDNKEEAIIKFNDFKYKWENKYPKVIYNTEKNLGKLLRFYNYPSSIWRSLKSTNAIERFNGEVRRRVKTISSFPDEDSAMKVFYYKSIEYNSKHAFRKMNGYYKCNDEIKEMFNRRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N564</accession>
    <name>A0A1V0N564_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886083.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N564"/>
    <dbReference type="STRING" id="74969.FAD_1432"/>
    <dbReference type="GeneID" id="16025754"/>
    <dbReference type="KEGG" id="fai:FAD_1432"/>
    <dbReference type="OrthoDB" id="136106at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614:SF2">
        <property type="entry name" value="TRANSPOSASE IS4-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="168"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="458" mass="53042" checksum="059D1379DEE69AF8" modified="2017-06-07" version="1">MNNMPDWVLEHKGKGIEIRRFGDRYYAYESSSRYDKDLKRARKVTGKYLGVVTPAGIIKKSDVSGIRGDYEYGNIALLYGIAGKTVLPVLKQVFPYMYDRIIIYVILRDIQPLPMKSLRYLYEKTYLSRMYRESMSPGSISGMLSSLPQEGMVNAMGKLTEKGEYVLMDSTAIFSRSDNISFLEPGHNSKEIHLPQINVMMLFSSTRTLPTFIRVLPGSIRDVSAMANTIDMAGIEKCVIVADKGFFSADNIKKLKKRHLSYIIPLRRNSSLVPDTDDFLGVFMYNGKPVKYWKPENGVYMFEDPVLKSEEERDYLIRIHDNIRPKSSYYDHSGDFGKLYLLSDINDEPERIYRLYKDREYVEYAFNVYKNDLEADRSYIRDDHMLSAYMFLNLLSLYLHFQVLNMIDGKYSVKDVLLILSRIKIYNTGKTEMVSEIPKKAKELISKLGIDLDILRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N568</accession>
    <name>A0A1V0N568_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RimK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142871.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N568"/>
    <dbReference type="STRING" id="74969.FAD_1383"/>
    <dbReference type="GeneID" id="31676875"/>
    <dbReference type="KEGG" id="fai:FAD_1383"/>
    <dbReference type="OrthoDB" id="33241at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043774">
        <property type="term" value="F:coenzyme F420-2 alpha-glutamyl ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054562">
        <property type="entry name" value="LysX/ArgX_preATP_grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="Rp_bS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621:SF2">
        <property type="entry name" value="COENZYME GAMMA-F420-2:ALPHA-L-GLUTAMATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 MODIFICATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22626">
        <property type="entry name" value="LysX_preATP_grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="90"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="274" mass="30651" checksum="2A23C3181ED24905" modified="2017-06-07" version="1">MLTFIYDSISWEEKELIKGLQSESIKLNLVNAKDNALNLTGKLDFEGPAVIRCMSSRRSLYYSYILESHGIKTINSFNTFSIAGNKVFTTSYLYKNGIKTPETSVSFSHDNALSTADNMGYPVVFKPASGSWGRMISLLENENIAETVFSMNDMVNENSYYLQKYVKRPPRDVRAIVVGDNISATIYRYSGEGWKTNLALGGKVEKAVLPESQLDILIRVAHLFDPGIIGIDAMETDEGLVVHEINSRVEFKGASKVYGNKIINDIVQYLKTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5A3</accession>
    <name>A0A1V0N5A3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Demethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menG</name>
        <name evidence="1" type="ORF">FAD_1416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142890.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5A3"/>
    <dbReference type="STRING" id="74969.FAD_1416"/>
    <dbReference type="GeneID" id="31676909"/>
    <dbReference type="KEGG" id="fai:FAD_1416"/>
    <dbReference type="OrthoDB" id="15246at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="220" mass="24379" checksum="6AFCB5C0B36A7FC2" modified="2017-06-07" version="1">MDNTSNKYYEDLKSKLYSAVISDSLDSFGFREQTMSPEIRPLNENMIVVGRAKTVLAADVYHIPEKHYFKQIEVLDSIRQGDVFVASVSGSKRSAFWGELMSTATKVAGGRGAVIDGLSRDTKKIIKLDFPVFSVGFRPTDSLGRNDVIDYDVPIECGGVKVNSGDLIFGDVDGVVVVPREIEKNVIQAALDKVDGENKVRDEILHGVKVSEVFRKYKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5C0</accession>
    <name>A0A1V0N5C0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142923.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5C0"/>
    <dbReference type="STRING" id="74969.FAD_1474"/>
    <dbReference type="GeneID" id="31676967"/>
    <dbReference type="KEGG" id="fai:FAD_1474"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="15"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="459" mass="48484" checksum="B85D4C1B133A1D5C" modified="2017-06-07" version="1">MKSSLKKDSLSLSNVIFQGVAGSAPAGAAVATLTGSAAFALGSLPLSAVVAFIIVLINAVIINRISRHVAGAGGYYAYSREGIGNFAGIFTGWMYIMYQIMSLAFIGLSVAIFLPALLGTVFGIDIPFYSWVLLLILIMGFGYFVSFSGVRNSVRYAMVMATIEVVVVAAVSIIIITAKPSINTVSVFTPVYAVHGFTGVMLGVLFMYTAFSGFGTATPLGEEAKNANAVIGKGVLISAIVLGLFFTLVSYAFTVGWGPTRMLTYSTELVPGIILAKNYLGLAGAIVITVLFVNSLFTDSVVFTNSLSRVVFSMSRDNVLPGILSSVHSHRQTPHVAAGVMVIISFIIGVISVITLGGFNAFLFAGIAATLSALLVHMIANASLAGILHKMKLKMNIAMDVVLPAVSIVILAFVFYGSFISIDNVVIIASVSFIVWAIAGLIYSAISRKYLMHVQISQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5D7</accession>
    <name>A0A1V0N5D7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Monovalent cation:proton antiporter-2 family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_1494</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142929.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5D7"/>
    <dbReference type="STRING" id="74969.FAD_1494"/>
    <dbReference type="GeneID" id="31676985"/>
    <dbReference type="KEGG" id="fai:FAD_1494"/>
    <dbReference type="OrthoDB" id="12029at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04603">
        <property type="entry name" value="CBS_pair_KefB_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="473"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD85350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="534" mass="58135" checksum="7709B648CF307732" modified="2017-06-07" version="1">MYGLSDSLLALLFIGALLLLAKLGEGLFEKFRIVSYVAAIIIGIIIGPGVLGLITILPNISLFISLGINFLLFTGGALEFKELETKKLLNPSNILTGVIEFILPFGLISFVVYYIFHSVLIALIVGLVTGMSSAGPLTRLLTDTGLNHTEEGNSIFQQVVTMEISGVILFSFLADLYGKVVTIYLVLKIAMELVVSLVFILLFSRYVLTRLLVKIDFSARANETVIAVIIGFVLVLGFVGQLYGFNSAIIALFIGISLREFINERPLVAEKVSTFTYGFFEPLFFIGLGLYFVKITLPLITLGLLIFAIAIILKPIAGTITSRFMHVDTWKNAFGTSVHGGVDAALLVVALGLSLIGRYDYSAVMIAITLLTVVIPALFNVKAPVVKTKKSNYVWEMVNAEFKNLKACDIASSFQSVSVNSKNPISLAFKMCTDLNARAVIVINSKLKVLGQLTLSDMVTMGHNQLRTLSVYQGKIVPAAKVLCDSPATDLIKIFKEYDPPIVAVVDKSGKFIGTILEREILKHVAGILDSDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5E1</accession>
    <name>A0A1V0N5E1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1485</name>
        <name evidence="2" type="ORF">HLB00_03045</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000098">
        <property type="protein sequence ID" value="NOL59812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886592.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5E1"/>
    <dbReference type="GeneID" id="16024717"/>
    <dbReference type="KEGG" id="fai:FAD_1485"/>
    <dbReference type="OrthoDB" id="41780at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="entry name" value="DsrEFH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DsrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="DsrEFH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="114" mass="12648" checksum="03DA7227213243E0" modified="2017-06-07" version="1">MSGKYLIIISSGLDQKGKMIVGLNFAKNIYRKKLAEDVKVVFFGPSEESLAKHDPDVDTLLKILRDMNVIQIACSGYAVAKNVSEDISKIGMKLEDVSDTITNFADQGYRIITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5G9</accession>
    <name>A0A1V0N5G9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="2 5 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="2 5 6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142942.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5G9"/>
    <dbReference type="STRING" id="74969.FAD_1523"/>
    <dbReference type="GeneID" id="31677014"/>
    <dbReference type="KEGG" id="fai:FAD_1523"/>
    <dbReference type="OrthoDB" id="4696at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000008">
        <property type="entry name" value="Ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="8">
        <location>
            <begin position="145"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="301" mass="34300" checksum="625A649CCF54F715" modified="2017-06-07" version="1">MKRDILSVADMENDFDQIIGTSIKLKKDRTIKFSDKKLLGMIFEKPSTRTRISLEAAMEQLNGHAIYLSPHEMHLGDGETIADTARVMSRFLDIISYRAYDYRNVRELAKYADVPVLNALDNMEHPLQIVADFMTIMEKKHRLENLKLAYVGDGNNVSNSLLLGAALTGMDISVACPEHREPDRDILYRAKDLALKTGSRIEILRDARTAVDSADIIYTDVWVSMGEEKEKDQKEKLFKGYQVNEELADFADKNYIFMHCLPARRGLEVTDEIIEGIHSVVFDEAENRLYSEKGVIYTVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5H0</accession>
    <name>A0A1V0N5H0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">nrdA</name>
        <name evidence="15" type="ORF">FAD_1541</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142950.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5H0"/>
    <dbReference type="STRING" id="74969.FAD_1541"/>
    <dbReference type="GeneID" id="31677032"/>
    <dbReference type="KEGG" id="fai:FAD_1541"/>
    <dbReference type="OrthoDB" id="6188at2157"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050862">
        <property type="entry name" value="RdRp_reductase_class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43371:SF1">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43371">
        <property type="entry name" value="VITAMIN B12-DEPENDENT RIBONUCLEOTIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14890">
        <property type="entry name" value="Intein_splicing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="13">
        <location>
            <begin position="548"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127954" checksum="130BCC7F9AF291D7" modified="2017-06-07" version="1" precursor="true">MNKVLNTVIKRDGSSVPFDKKKIAMAIFKAMLSVKIGSMEEANKLADYVAQELETSSEVPTVELIQDTVEKVLMTRRINDVSYIAAAKAYILYREKRNTIRQEKEFIGVKDDLKLSLNAVKVLEARYLFKDSEGKIIETPKQMFHRVAVHLGIIQGLYDYISYRKTGKLNEKGTVYTGITKTQDEELQRAFNELKKEKAIDGTYTEFIDFIKTKKNMINYWIEKFENMMIKLEYVPNSPTLMNAGGPLGQLSACFVLPVDDSIDSIFDTLKATAEIHKSGGGTGFSFSRLRASDDIVASTKGVASGPVSFMRIFDVTTDVIKQGGKRRGANMGILNYNHPNIMDFINSKDVENKILSNFNISVGVNDEFFEKLDNDENVDLINPRDGKVTGRVKATTLWNSIIDHAWLTADPGMIFLDEINKKNPVKNIGYIESTNPCVTGDTKIFTSEGVKKARQLYEEGNPLNVKIDGRFGGEFKPSSNVIYTGFKDIYKIQTKEGFEIKVTGDHKIYSEKNGWTEALNLKENEKIRILNEGGSFGSSGTLEEGRVLGWLVGDGHINNGNNNDRAVLNFYSQDRVFADTFRKYVNDIVRPATNNREYNVGMVNIESRNCITIASERLKEFASEYDLIEEKLNVPDKVFAGSMELQRGFLQALFEADGTVYSGQKSRHSVRLGSISLNLLKQVQMLLLNFGIYSRIYQNRKKAGMRMLPDSNREMRLYATQDFHELNISAENLIKYADSIGFISERKNSKLNGAVNSYKKAPVKPSWLARVDKIEYVGREDVYDLVEPSTHSFVANGIVVHNCGEQPLLPYESCNLGSINLAKFVEDGKFNYERYRETIDVATRFLENVVDANKFPVESIKNMTRKTRKIGLGIMGFADALIMLGIPYNSNEALEFAENVMKTLNDESHMESQKLAAERGVFPGWYGSEYEEKGIKMRNSTTTTIAPTGTISIIAGCSSSIEPLFALAFVRHVLNGQELLEVNPLLENALKSRNLWTQELMEKIAETGKLGNLDLPEDVKNLFITAQEIDPDWHVLMQATFQKYCDSGVSKTINLPFDATREDIAKSYRLAKELHCKGITVYRDRSKSQQVLYAGTNQKKSDEEHKIDLTMKMPDKLLKLGATFDPACPTGKCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5H9</accession>
    <name>A0A1V0N5H9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isovaleryl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="4">1.3.8.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_1551</name>
        <name evidence="16" type="ORF">HLB00_00940</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Berkeley</strain>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:12276"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57345"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.4" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5H9"/>
    <dbReference type="STRING" id="74969.FAD_1551"/>
    <dbReference type="KEGG" id="fai:FAD_1551"/>
    <dbReference type="OrthoDB" id="275197at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000007">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="13">
        <location>
            <begin position="113"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="12">
        <location>
            <begin position="214"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="NOL59405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="374" mass="41426" checksum="4CC7CBAABDB7C1CB" modified="2017-06-07" version="1">MIQQSAKEFAEKEIIPVAAKMDRENFFPRELFRKMGKEGYLGVTIPEQYGGSGSDYVSQAIIEEEISYASGSLGLSYGAHSNLCLDNLYRNGSEYLREKYLEKLCSGEHVGSLGMTEPSSGSDALSMKTSATMDKGNFILNGSKTFITNAPYADIFLVYARTGENITPFVVESSDRGFSRGQEFDKTGMRGSPTGTIFFNDIILPENRIVGKLNGGRNVLLSGLNLERAVLAFNSIGIARRALDLAIGYASERKQFGRPISDFELVQEKLAYMYTKFESSRLFAMEALKRVQEDRMDSLDAASAILYASESSEYIAREALQIFGGYGYIKDFEIERVFRDSILLTIGAGTNEIRKKVISEALIKKYGKGGKSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5I4</accession>
    <name>A0A1V0N5I4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="9">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA wyosine derivatives biosynthesis protein Taw1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">taw1</name>
        <name evidence="12" type="ORF">FAD_1512</name>
        <name evidence="13" type="ORF">HLB00_07725</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Berkeley</strain>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000289">
        <property type="protein sequence ID" value="NOL60717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886651.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5I4"/>
    <dbReference type="STRING" id="74969.FAD_1512"/>
    <dbReference type="GeneID" id="16024778"/>
    <dbReference type="KEGG" id="fai:FAD_1512"/>
    <dbReference type="OrthoDB" id="68499at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01921">
        <property type="entry name" value="TYW1_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023993">
        <property type="entry name" value="TYW1_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03972">
        <property type="entry name" value="rSAM_TYW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="60"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA wybutosine-synthesis" evidence="11">
        <location>
            <begin position="239"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="NOL60717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="325" mass="37199" checksum="A8166D3B76323B31" modified="2017-06-07" version="1">MINNYEAVYKKQHYGLVGSHSAVKVCHWTKSELLGKAPCYKNTFYGIKSHQCIQMTPALNQCSENCDFCWRFQGFDSMHINEEDDPEFILEESIKAHLKLISGFKGNPKVKKELFEEASHPRHMAISLTGEPTLYTRLGELIEAATRRGITTFVVSNGTMPKVLETLNPLPTQLYITVAGPTKEIFNDVLHPAIGNAWENFNKTLDLLPSLDTRTVIRHTMVKNVNFPFYDEYEKMDRRADPDFIESKGYVHVGQSEGRLTAENMPSHDEIMEFSSTLAKRLGYTEYADRFESRVAMIAKHPEDAKIDVDREIRKTLDKLEITEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5I9</accession>
    <name>A0A1V0N5I9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1544</name>
        <name evidence="9" type="ORF">HLB00_03555</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000114">
        <property type="protein sequence ID" value="NOL59909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886684.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5I9"/>
    <dbReference type="STRING" id="74969.FAD_1544"/>
    <dbReference type="GeneID" id="16024813"/>
    <dbReference type="GeneID" id="31677035"/>
    <dbReference type="KEGG" id="fai:FAD_1544"/>
    <dbReference type="OrthoDB" id="57573at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="15"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="421" mass="46070" checksum="21E2A40B5B64DB5C" modified="2017-06-07" version="1">MERQVKKKPVANAYYISIGAISIFVASYNIAIISVALKPIENAFQTGTGIVYLLGALIFVGAMIGAIISGVFSDRFGRVSILTIDIVTFIGAGIGSALSTNIAMLMFFRTLVGVGVGIDYVVIFTYISEILATKNSTRNLALIMFFANFGILFSYLIGGTLLTLGSTGWRYALLSGAILAIVPLIMRSRLKESTLWKFKRIKSIKTILKDVTSRENRKYLYRFSIPWFLYQIGDQSLTMFLPFILISALGISVVSGAFSAVLVKAFTIPASIVAFLIIQRLGTRKLQATGFIIRSVFLGILGFGLYFALRFTGIEIIILLGFAFFFGSMGPDKTTVIMPVEKYDESIRGSGQGFNEMAGRFGGLIGILAFALFGMAGIDIGLIFLSITCILGFIITVICRDKNIVENISKNAKEEYYARTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5J9</accession>
    <name>A0A1V0N5J9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1507</name>
        <name evidence="6" type="ORF">HLB00_07750</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. RimJ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000289">
        <property type="protein sequence ID" value="NOL60722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142937.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5J9"/>
    <dbReference type="STRING" id="74969.FAD_1507"/>
    <dbReference type="GeneID" id="84218100"/>
    <dbReference type="KEGG" id="fai:FAD_1507"/>
    <dbReference type="OrthoDB" id="120213at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF8">
        <property type="entry name" value="[RIBOSOMAL PROTEIN US5]-ALANINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="177" mass="20086" checksum="AE496DB17F856FB7" modified="2017-06-07" version="1">MADYTIKSGNIVITTKFPREHINEFVSCANDSSLGLNLMSHGFHYPYTEEDAMEFIDKNREVEGESFAIDFYIIYENNVAGVIGLSDIDYDNSRSHVGYWIGKDYRGKGIATEALKAVIYFAARTLRLHSLYTSALIDNIGSIIVLTRNGFSIDGISKDCFMYDNRFYSAFMFSQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5P2</accession>
    <name>A0A1V0N5P2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5P2"/>
    <dbReference type="STRING" id="74969.FAD_1577"/>
    <dbReference type="KEGG" id="fai:FAD_1577"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01081">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31648" checksum="B6036CE62F4189C8" modified="2017-06-07" version="1">MQLYPMSDFEIVGAEDFFATIYRRGAYVGQIVKNGKKILKETEDGVDIKGGIPILVPYGDLVRDAKYTFHGTEYHLPKNAHVVGNYRDSIHGLTRSQEWNVKKRNDNSISLFTEINDPGYPSILGVEITYTIIEGSFDASISVVNTGEMPAPLVIGAHPYFITSGPWKLHHQERIQMLNYPDGVFPDGKLMDYSFNDIDNPEKLNLDSSFVGGGALKLESKYSTIILERINMTYFEVYNGTFAGKDSVALEPLTGAIDAFNNGMGLKELASGEKFKCGFRITVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Q8</accession>
    <name>A0A1V0N5Q8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein uL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpl1</name>
        <name evidence="13" type="ORF">FAD_1619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Binds directly to 23S rRNA. Probably involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Probably involved in E site tRNA release. Binds directly to 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886750.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Q8"/>
    <dbReference type="STRING" id="74969.FAD_1619"/>
    <dbReference type="GeneID" id="16024884"/>
    <dbReference type="GeneID" id="31677108"/>
    <dbReference type="KEGG" id="fai:FAD_1619"/>
    <dbReference type="OrthoDB" id="10382at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000005">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_A">
        <property type="entry name" value="Ribosomal_uL1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023669">
        <property type="entry name" value="Ribosomal_uL1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003244">
        <property type="entry name" value="PRK04203.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 11 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 11 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4 11" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD85463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="214" mass="23797" checksum="372E536C1114EF09" modified="2017-06-07" version="1">MENSIIENLKELKELKKRNFDESIEVGINLKDVDMVDPKNRINEEIILPAGRGKDLKVAVIASEEMRTKAKNADYLYSVEDLNNFSDNKKSFKKIVKGIDFFVAESTLMGNVGKNLGIILGPRGKMPKPLPPGQDPSALIENLKKSVRARSRDKITFHVPIGTKAMSNEDLFTNLNTVLKRIISHLDKGKGNIASAYIKSTMSKAITINLGDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5S5</accession>
    <name>A0A1V0N5S5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl44e</name>
        <name evidence="5" type="ORF">FAD_1654</name>
        <name evidence="6" type="ORF">HLB00_04435</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000151">
        <property type="protein sequence ID" value="NOL60082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886791.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5S5"/>
    <dbReference type="STRING" id="74969.FAD_1654"/>
    <dbReference type="GeneID" id="16024923"/>
    <dbReference type="KEGG" id="fai:FAD_1654"/>
    <dbReference type="OrthoDB" id="52456at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01476">
        <property type="entry name" value="Ribosomal_L44e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004425">
        <property type="entry name" value="PRK05767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="93" mass="10993" checksum="D2D915B96E4680C1" modified="2017-06-07" version="1">MKMPKQIKTYCPYCKKHTVHDVERVRKRKASELRAGQRRFRRVTSGYGGFPRPRYEGREKPTKRIALRLKCTVCKKSITPPTQRAKKFEIVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5T3</accession>
    <name>A0A1V0N5T3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143008.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5T3"/>
    <dbReference type="STRING" id="74969.FAD_1664"/>
    <dbReference type="GeneID" id="31677155"/>
    <dbReference type="KEGG" id="fai:FAD_1664"/>
    <dbReference type="OrthoDB" id="275197at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000026">
        <property type="entry name" value="Acyl-CoA dehydrogenase medium chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF37">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="233"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="385" mass="42420" checksum="27082EF1D1535842" modified="2017-06-07" version="1">MDFSLSDEQKLLRKNTAEFLEKNLKPFVREIDNNGEIPVEFFRKAGENGIISPLIKLKYGGPSLSFMDSVIISEEIARIDTSMATSVYYLLNTSWAYVLQKYGKQELKDKLLPEIANGSRFIGIASTEPSGGSDVANITTTGRIENGKVIINGEKMYISGAVEAKKNGGGHLTLVKTKEGVGHKGITMVYVPANADGIEITKLNNMGRMGISTSGIKYTNVEVPEENIIGEINEGFYYSMDGFNHARIMVAAACNGLSYKMLEEGLNYIKERKAFGKHLSDFEAISFEAADLRTDIEMAALLNYKAAYLADVEDPDFYIYSSMSKLKSPQIAMDTTKKVMMWFGAYGYTKDSGIEMAARGIFSYLVGAEGALNIMKVIISKAILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5W5</accession>
    <name>A0A1V0N5W5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1641</name>
        <name evidence="4" type="ORF">HLB00_07220</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000264">
        <property type="protein sequence ID" value="NOL60618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142990.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5W5"/>
    <dbReference type="STRING" id="74969.FAD_1641"/>
    <dbReference type="GeneID" id="84218233"/>
    <dbReference type="KEGG" id="fai:FAD_1641"/>
    <dbReference type="OrthoDB" id="56422at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="193" mass="21954" checksum="E4A613E451E47ED4" modified="2017-06-07" version="1">MDEDLWSILIALENNTRREMLKTLANYNSYGLELSRMIGVSQQAINKQLEILEKLGLICTDGSIPSTMGPPRKVYRSMGFSTIIIDYSKNFMKIKKMDIDYGDENIEGNNSDLVNKLNNLNGEIDKIDRERNLLSSKKDAIIGMLKERASGFDNFYRKVIYGYLETMDISIVAHNMGIPEELVKGIVDKFLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5X3</accession>
    <name>A0A1V0N5X3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">tRNA (guanine(10)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="13">2.1.1.213</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA:G10 dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FAD_1651</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43124"/>
            <dbReference type="Rhea" id="RHEA-COMP:10355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10358"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.213"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the methyltransferase superfamily. Trm-G10 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.213" evidence="13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5X3"/>
    <dbReference type="STRING" id="74969.FAD_1651"/>
    <dbReference type="KEGG" id="fai:FAD_1651"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160101">
        <property type="term" value="F:tRNA (guanine(10)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000251">
        <property type="entry name" value="Putative RNA methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053943">
        <property type="entry name" value="RlmKL-like_Mtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF21">
        <property type="entry name" value="N2-METHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="15">
        <location>
            <begin position="143"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD85495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="317" mass="36294" checksum="120F9F4C2CE8729A" modified="2017-06-07" version="1">MELSGENIEIAYTEIKSIQETYKNFQIIFLSGKFALIDGDPAKVMNSAFTNYISRVINESDDYKNFTGTEIPDGFFYVRVIGKAKTETEGIESEIGRNLGGKGRISFKNPDFIVRAIFLDKWYLCILTYERDKKRFEERRAPMRPFFSPVSLHPKYARYLVNTSGTVEGDTLLDPFCGTGGILIEASMLGRKIIGNDSELNMVMGTKLNFKYFGIENYKMYNLDIASLSLDKKVDGIVTDMPYGRSSGVNNHDIVELYKESFIKFNELLKSRGKCSIIVNNTQFLDYAVKYFNIEKIVPVYQHKSLIRQFVILSRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5X7</accession>
    <name>A0A1V0N5X7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase with FAD/NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fixC</name>
        <name evidence="6" type="ORF">FAD_1660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143003.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5X7"/>
    <dbReference type="STRING" id="74969.FAD_1660"/>
    <dbReference type="GeneID" id="31677149"/>
    <dbReference type="KEGG" id="fai:FAD_1660"/>
    <dbReference type="OrthoDB" id="7950at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059103">
        <property type="entry name" value="FixC-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-QUINONE OXIDOREDUCTASE YDIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624:SF2">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-QUINONE OXIDOREDUCTASE YDIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26311">
        <property type="entry name" value="ETF-QO_FixC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FixC-like C-terminal" evidence="5">
        <location>
            <begin position="362"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="421" mass="46535" checksum="776C471356DDD88C" modified="2017-06-07" version="1">MDYDVDVAVVGGGLAGISAAISAAKNGLSVIVLERGEHSGSKNVSGGRMYIHSLKTLLGDRYRDAPLELPIKKETFEIYTGNNKASFSFENKETENSYSILRSRFDAWFASEAENLGVPVSYSTLVSGIDREDGGLVVKSDRGDIRTPLVIESDGAAGFASRYLGIRKEKAFKMQPVKNLQENPDFMPKQFMVGVKEIVDKKPDADYGEAKTILGLSNGVKGGGFAYTNKDSTSIGLTLKLDSLEGHSEKAFDLIEDFREKLGIEGKLLEYSAHLIPFYRFETLPARYVDNLMVTGDAAGFLINDGFTIRGMDNAIESGRLAGEAAKKITDSGDFKDTYIYEQMLENSFILKDMQAASRISTLFGNERTFDAYPKMMAGILERMFTVTDNPRENIKSVLMDEIKKNNIGYYTLLQDMLKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5X8</accession>
    <name>A0A1V0N5X8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VapB-type antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886833.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5X8"/>
    <dbReference type="STRING" id="74969.FAD_1692"/>
    <dbReference type="GeneID" id="16024964"/>
    <dbReference type="KEGG" id="fai:FAD_1692"/>
    <dbReference type="OrthoDB" id="377567at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="78" mass="8947" checksum="BA60F94BE30A1DD0" modified="2017-06-07" version="1">MVKTTINLDDEIYAEIVRESIEKYGSTKNMSKIINQRLGNKKSDTGKSGKRITFNVREDLASLDADKEIKKGWKARDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N600</accession>
    <name>A0A1V0N600_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143066.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N600"/>
    <dbReference type="STRING" id="74969.FAD_1739"/>
    <dbReference type="GeneID" id="31677230"/>
    <dbReference type="KEGG" id="fai:FAD_1739"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010266">
        <property type="entry name" value="NnrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05940">
        <property type="entry name" value="NnrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="399" mass="43466" checksum="DC9C9669E142C7F8" modified="2017-06-07" version="1">MPDPIALKKKGAGLPVQHPPRIVYIGILLSALSLAAGFLTGIAALAVNNGYPSIIPLANGITFHPDLMVFGAVGGLLISEKLELMEKFPLIRNIPISRPIVAFLFGGVFILSLGILSSYAVARYAGLLLVVAASLLFLLFMSSNVNHGDKRIKLVFAAAIASMSLAAIGNMNSLLYSDVKLTFLALLFPILYILAERMELGFVRGMGARIMALQAYIAWFAVGMAFVSVEVPDKFISRFAMVLSIILVAILTGISIKFDPAFRKIKRNGRFQHFMRAGIQISFFWLALGLILFMLQAIIGHGYLDPATHSIAIGFIGSFIVAHSPVIFPLTFKKKAIQENVTFLPLIMITIANVSRVFGDLAIPYTSLGETFSYVSGYLLLFAILLFVYNIKKIMVSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N612</accession>
    <name>A0A1V0N612_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1704</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143038.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N612"/>
    <dbReference type="STRING" id="74969.FAD_1704"/>
    <dbReference type="GeneID" id="84218324"/>
    <dbReference type="KEGG" id="fai:FAD_1704"/>
    <dbReference type="OrthoDB" id="27277at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="202" mass="22376" checksum="8B4902D7FB8B737C" modified="2017-06-07" version="1">MYNIVVLASGNGSNFQAVVDAIDNGVINDAKISKLICNNKRAYVLQRARNSGIMPVLVDSKKEDYNNIISEILAAENPDLILLDGYMKIIPDNIIDAYPFKMINLHPSLLPAFGGKGYYGGKVHEAVIKSGARFSGCTIHFATKDVDNGPIIDQRVVEVSDSDTPESLEEKIHEEEHKALVYSINLLITKRYSINGKRVIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N620</accession>
    <name>A0A1V0N620_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143025.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N620"/>
    <dbReference type="STRING" id="74969.FAD_1684"/>
    <dbReference type="GeneID" id="31677176"/>
    <dbReference type="KEGG" id="fai:FAD_1684"/>
    <dbReference type="OrthoDB" id="374223at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="163" mass="18439" checksum="06CBFBF87C4C0729" modified="2017-06-07" version="1">MRLIIDTNVILAYLISGSGSSANGKVCKRVVNGSDKAFTCDILYGELKRLLDLDPDLVEKISRSGKKEGDVFRALNNVRPEYLNSRLDPYVMQLNFIKTENLTIDPTAIQDVGNDWYMISIAKSVSIDYIVTWNTKHVLRYATVNGIDVNRILEPPKYLELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N627</accession>
    <name>A0A1V0N627_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1743</name>
        <name evidence="2" type="ORF">HLB00_03905</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000127">
        <property type="protein sequence ID" value="NOL59977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886885.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N627"/>
    <dbReference type="STRING" id="74969.FAD_1743"/>
    <dbReference type="GeneID" id="16025018"/>
    <dbReference type="KEGG" id="fai:FAD_1743"/>
    <dbReference type="OrthoDB" id="384860at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="299" mass="34032" checksum="0D9AC396B7BAA801" modified="2017-06-07" version="1">MLEIKNYITKKYEQGNDNIETLISLMNTFVSEIYGSSVAVDPDSIENIEKLHAYIDVFQQKILGNTLLIRKFSHIFYISAEQVNGRANFTGPDRKTAIKLLEDVKSSLTAAGEAKLLESIASNLSRIGEVQMSLTPVMEILRELVEKKRLILVSDKKSDAKRLKYFNEVGDLAIFSYEYKYGACIIEPGPEFDAVASEGIENLLSYVMSHRILYISGISSLKPYLRTAYSYYSLCSLAGHMMEISSEDLRKEYGELYGREPDKLKFKNYIESLYNSNVFTNIDTKINGDKTIFENFIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N637</accession>
    <name>A0A1V0N637_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAGO protein related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N637"/>
    <dbReference type="STRING" id="74969.FAD_1779"/>
    <dbReference type="KEGG" id="fai:FAD_1779"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050638">
        <property type="entry name" value="AA-Vitamin_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32322">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32322:SF18">
        <property type="entry name" value="S-ADENOSYLMETHIONINE_S-ADENOSYLHOMOCYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="135"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="284" mass="31643" checksum="0AEDB5CFD99D36AB" modified="2017-06-07" version="1">MVISWSINYPVIKIALNYTGPFTLLFYRILFSSIFIYIIFRPKLHLRITKAEIIPLFILSLLNVLIWMELWFLAETTISASLTSIIIYTYPIISTLMAIVFLKEQYNKYVFLGIGIGFAGLLVIFSNSLLSGFKPGIIIALLGAIVWAIGTIYFMKYHVKRDRESTNFFQMGFALLPSLLIAGIATPSISIFEPSLILILLVLIIAIPGTAVAYFAFLHLNRKYGVSTVSSFLFLVPALSVVFSIIILNEIPSFYEIIGLALVGIGIYFSARGTKIKASAKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N661</accession>
    <name>A0A1V0N661_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1736</name>
        <name evidence="3" type="ORF">HLB00_03865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000125">
        <property type="protein sequence ID" value="NOL59969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074044.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N661"/>
    <dbReference type="STRING" id="74969.FAD_1736"/>
    <dbReference type="GeneID" id="16025011"/>
    <dbReference type="KEGG" id="fai:FAD_1736"/>
    <dbReference type="OrthoDB" id="46008at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050407">
        <property type="entry name" value="Geranylgeranyl_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685:SF22">
        <property type="entry name" value="CONDITIONED MEDIUM FACTOR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="380" mass="42442" checksum="61D801422678D4BC" modified="2017-06-07" version="1">MYDVIVSGAGPSGSYLSYLLSRNGYKVLQLEEHREVGKPVECTGLVSERVFKYVNSRSMVNEVHGANVFFPNGKSIHISKGEKTIVMYRDDFDKDVSAMAIGAGADTRINARVLDAKVNDSYGEVKYRENGEIKYARANIIVGADGANSRIRLSLNYERPKKIISTYQVDSSFHLDDQDDVNVFIGSENSKGFFGWAVPSGEITRIGVGVDHVTAIKYFRNINVKFNRSQILGINAGPIPINYLSKTYGNRSLLLGDAAGIVKPLSGGGIYTGIISAKNAYTAIDQSFNRNNFSEDALKAYQKLWKREIGRELFIDAKIQQYFSKISTNDTLLNKIYDTINREDIIRRINSLGDIDYPAKVVFSILMRKPQLIKYFLFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N663</accession>
    <name>A0A1V0N663_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="5">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hisS</name>
        <name evidence="8" type="ORF">FAD_1768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143078.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N663"/>
    <dbReference type="STRING" id="74969.FAD_1768"/>
    <dbReference type="GeneID" id="31677259"/>
    <dbReference type="KEGG" id="fai:FAD_1768"/>
    <dbReference type="OrthoDB" id="8659at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707:SF1">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="32"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="273"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="429" mass="49425" checksum="187BB3420EA5248D" modified="2017-06-07" version="1">MKVEKLKGFRDHYPEDMEVRNYFFKKITNAAENFGYQLIDFPSLEPLDLYRLKSGTEIVNQTFSFTDKGGREVTMIPEATPSTVRLLTARKDLPRPVRWYSFPKVWRYEEPQEGRFREHYQFNADVFGLDSEEADAEIVGLASSILDYLGLSGVYEININDRFLMEYVLKDLNIEDIPDAFSIIDKYKKVDKSSFVEAFKGIGAGEDEIKKILSLLGEKVDIGNLEKKIKRVVNNYEEIKPRIERIKKTFDLIGLYTESKINFDFSIVRGLSYYTGIVFEAFDVKGELRAILGGGRYDGLSQLFTQEKIPAAGFAIGDAVIELLLKRQNLWLKRNMKESYYICNLSSENYDYIIKIASVIRSLNKIAVVDMTHRKISSQMKSASDFDFAIIIGEREIEEETMTVKNMHSSEQSTIGYDEFFLKLRSGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N670</accession>
    <name>A0A1V0N670_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1783</name>
        <name evidence="2" type="ORF">HLB00_08030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000298">
        <property type="protein sequence ID" value="NOL60774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886931.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N670"/>
    <dbReference type="STRING" id="74969.FAD_1783"/>
    <dbReference type="GeneID" id="16025062"/>
    <dbReference type="KEGG" id="fai:FAD_1783"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="85" mass="9637" checksum="4653700E382EAC01" modified="2017-06-07" version="1">MDCENVLEILGNTEMTQDQIADKMIGKYSTSDNSKAGYLKIGAQILVENELEFLLNEMVDSNKLGIKKVQNGLLERVYYYARNPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N698</accession>
    <name>A0A1V0N698_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsuE family. Isf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143104.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N698"/>
    <dbReference type="STRING" id="74969.FAD_1814"/>
    <dbReference type="GeneID" id="31677304"/>
    <dbReference type="KEGG" id="fai:FAD_1814"/>
    <dbReference type="OrthoDB" id="9059at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="184" mass="20834" checksum="B880933916CD8002" modified="2017-06-07" version="1">METIKIAGFGGSLRKESYSRYLLENAVGLMPENSKLEILDIKNFPLMNQDEENNYPENVKKFKRQIKESDGVLMVTPEYNYSIPGYLKNVLDVASRPYGDNPFNGKPVAIMSSSIGMLGGSRAQYHLRQVCVFLDMIPVNTPEVFLTFAQDKFDEKGKLKDEMTAKFAGQLLQNLVNLARQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6A5</accession>
    <name>A0A1V0N6A5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-sulfur cluster assembly factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative aromatic ring hydroxylating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1780</name>
        <name evidence="3" type="ORF">HLB00_08045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000298">
        <property type="protein sequence ID" value="NOL60777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886928.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6A5"/>
    <dbReference type="STRING" id="74969.FAD_1780"/>
    <dbReference type="GeneID" id="16025059"/>
    <dbReference type="KEGG" id="fai:FAD_1780"/>
    <dbReference type="OrthoDB" id="371709at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052339">
        <property type="entry name" value="Fe-S_Maturation_MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42831">
        <property type="entry name" value="FE-S PROTEIN MATURATION AUXILIARY FACTOR YITW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42831:SF1">
        <property type="entry name" value="FE-S PROTEIN MATURATION AUXILIARY FACTOR YITW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="100" mass="11354" checksum="D5AFAEDDC8DE625C" modified="2017-06-07" version="1">MVTKEEVLEALKEVSDPEIGMDVVNLGLVYDVEITDGNRVYIKMTMTAPTCPVTPWILSEAQKSVENLADVEAADIELVWDPQWNPEMMTDYAKEQLNMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6A9</accession>
    <name>A0A1V0N6A9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc-containing ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_1852</name>
        <name evidence="14" type="ORF">HLB00_05560</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Berkeley</strain>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="10 11">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10 11">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000186">
        <property type="protein sequence ID" value="NOL60299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887001.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6A9"/>
    <dbReference type="STRING" id="74969.FAD_1852"/>
    <dbReference type="GeneID" id="16025135"/>
    <dbReference type="KEGG" id="fai:FAD_1852"/>
    <dbReference type="OrthoDB" id="23833at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009157">
        <property type="entry name" value="Fd_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053687">
        <property type="entry name" value="Zinc-ferredoxin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041165">
        <property type="entry name" value="ZFX_Thplmales"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF6">
        <property type="entry name" value="L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000068">
        <property type="entry name" value="Zn_Fdx_Sulfol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10 11" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="2 10 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000068-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD85688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="NOL60299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="144" mass="16112" checksum="A046AF733E1EB8DB" modified="2017-06-07" version="1">MVQREDVDFDPKHIDENFMSDEKNYPVTGEEDGLKVRAGGMQRMDDNGKPYPTKLGIHGTTVAVDWDGCIADGSCMDVCPVDLFEWKLNPGNSGTGNDKKVEKGTPEWEKYRTDKSNPVRESECIFCMACVTACPWSVIKVNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6D0</accession>
    <name>A0A1V0N6D0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143113.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6D0"/>
    <dbReference type="STRING" id="74969.FAD_1833"/>
    <dbReference type="GeneID" id="60420018"/>
    <dbReference type="KEGG" id="fai:FAD_1833"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="94" mass="11446" checksum="0001D5E5AA589956" modified="2017-06-07" version="1">MKKKKRIESWLKNKFKKLFINFSGLWINKYIGFYCNGMLKRGFGVAKAINYKALVYFQWKLFIYKCYESKKLLIEMKNNTRTYIGGRGVYFLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6D3</accession>
    <name>A0A1V0N6D3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1857</name>
        <name evidence="2" type="ORF">HLB00_05535</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000186">
        <property type="protein sequence ID" value="NOL60294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887006.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6D3"/>
    <dbReference type="STRING" id="74969.FAD_1857"/>
    <dbReference type="GeneID" id="24787188"/>
    <dbReference type="KEGG" id="fai:FAD_1857"/>
    <dbReference type="OrthoDB" id="350804at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="74" mass="8656" checksum="02DEF369639FB825" modified="2017-06-07" version="1">MEQELKMLTPSTRLVFMMLRQMKVARLCQIIESTGLSRRSVLYSVKKLNSLGLIEISICLSDTRQRFYCIKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6E9</accession>
    <name>A0A1V0N6E9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1855</name>
        <name evidence="3" type="ORF">HLB00_05545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000186">
        <property type="protein sequence ID" value="NOL60296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887004.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6E9"/>
    <dbReference type="STRING" id="74969.FAD_1855"/>
    <dbReference type="GeneID" id="16025138"/>
    <dbReference type="KEGG" id="fai:FAD_1855"/>
    <dbReference type="OrthoDB" id="111898at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33930">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE AHPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33930:SF2">
        <property type="entry name" value="BLR3452 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="112" mass="12533" checksum="923CA30387ECD3BF" modified="2017-06-07" version="1">MDAGKKMEEVGRVMQSISEDNKEYMGAFMGLMQNTMRAGTLSVKQKELIALALSIAARCEWCISYHVKSAIEAGATKKELMETGYVVVLMYGSQAMMELNSMLDAIEKFYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6G3</accession>
    <name>A0A1V0N6G3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homoisocitrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hicdh</name>
        <name evidence="8" type="ORF">FAD_1839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143117.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6G3"/>
    <dbReference type="STRING" id="74969.FAD_1839"/>
    <dbReference type="GeneID" id="31677329"/>
    <dbReference type="KEGG" id="fai:FAD_1839"/>
    <dbReference type="OrthoDB" id="6813at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="356" mass="39860" checksum="457083533EB3287D" modified="2017-06-07" version="1">MVDIAVIPGDGIGKEIIPQACDLVTSIDPSVNFTFYNISSERYINEGITIKDSEIDELKSYNSIFFGAIGDFRVKPGIMEQGVILRLRKELDLYMNIRPAISFSRITGNNIHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKNLKRFFNMAYKIADTETVTITDKANAVDMYSLWREIAIEESEPAGKKINFEYADSLAYNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPSGNIGDYSSMFEPVHGSAPDIAGKNIANPVASILSCIMMLKHLNQTETAGIMEKSVENVIRNGTIPIESGGNAGTHEFINKVKNYCTMTKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1K1</accession>
    <name>A0A1V0N1K1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Thymidine kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tdk</name>
        <name evidence="11" type="ORF">FAD_0066</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>thymidine + ATP = dTMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1K1"/>
    <dbReference type="STRING" id="74969.FAD_0066"/>
    <dbReference type="KEGG" id="fai:FAD_0066"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="THYMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441:SF0">
        <property type="entry name" value="THYMIDINE KINASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="187"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD83999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="216" mass="24382" checksum="BC32BA9FE4BA6976" modified="2017-06-07" version="1">MLVKNLYELIILTIMKNIIIGKLTVITGPMFSGKTSRLIELLEREILAGRNTLLFKPEMDKRYDTTFVTTHKGMRLPAIVLNTDNEGVEKMYNLSKNVDVIGIDEAQFWNHGSILPEIADKIASENKIVYAAALNKNHLGNPFKTSMDIISRADQVYSLTAVCAKCGEDATFSQRILNGKEIFGEQIKIGGMESYEPRCRKCFVYPDVSEVQRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1L9</accession>
    <name>A0A1V0N1L9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Slipin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Stomatin family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0049</name>
        <name evidence="8" type="ORF">HLB00_02655</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000085">
        <property type="protein sequence ID" value="NOL59734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887060.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1L9"/>
    <dbReference type="STRING" id="74969.FAD_0049"/>
    <dbReference type="GeneID" id="16025195"/>
    <dbReference type="KEGG" id="fai:FAD_0049"/>
    <dbReference type="OrthoDB" id="10752at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD83984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="281" mass="30641" checksum="3835A8E98CF9D5FC" modified="2017-06-07" version="1">MVAIDVGEVILILVLIIIVAIILSGIHILKEWQRAPVLTLGRYTGLKGPGLVYVTPIISKITVVLSTRIQAVAFKTESTFTQDNVPVNVDAVMYFQIIDPDKAVLNVENYAAATQLAAQTTLREVLGKSSFDEILSEREKIGESARQIIDEKTEHWGVKVSSVEIRDVLVPQTLQDAMSRQAAAERERRSRVTLALAEVEAAGKMVDAAKQYANNPTAFQLRWMDIVYQIGLEGKGSLIMIPQNVPTVGDTSQFFTATALNNILSKSTGNVGNSTNSGSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1N5</accession>
    <name>A0A1V0N1N5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Probable cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobQ</name>
        <name evidence="10" type="ORF">FAD_0084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141305.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1N5"/>
    <dbReference type="STRING" id="74969.FAD_0084"/>
    <dbReference type="GeneID" id="31675596"/>
    <dbReference type="KEGG" id="fai:FAD_0084"/>
    <dbReference type="OrthoDB" id="53136at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001989">
        <property type="entry name" value="PRK00784.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="COBYRIC ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343">
        <property type="entry name" value="DETHIOBIOTIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobQ/CobB/MinD/ParA nucleotide binding" evidence="8">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CobB/CobQ-like glutamine amidotransferase" evidence="9">
        <location>
            <begin position="247"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="473" mass="52316" checksum="6D58A4761D6207F6" modified="2017-06-07" version="1">MVKMIQVLGTSSDSGKSTLAMSLCYYFSRKGYRVAPFKAVNMSLNSISLKDSSEISRAQWLQAIAAGAEPSKYMNPFLIKPEGMGKSQIVVEGKSIGSMKIEEYYSYLKNNAEAIIKGAIDRLSGEYDIIISEGAGSAAEINMQDRDFANSYVSSMYGTPAILISDIEKGGVFASLYGTVKLMPDSNLVKYLVINRMRGNSDMLSPGILKLEELTGKKVIGVIPYSGISLPGEDSLNYNKPAIQNHRICIIKYPHMEVYSDFDPFYLLNIGFTFVDKDNIDALDRCDVIILPGSKLVGEDLHYMEKYGIASKLISLQATKTIIGICGGYQMLGKRVIDNDNVESGEREIKCLEILDIDTEFKNKKITGAVNYTLNDKIFPGGIHGEGYEIHYGSIVRNMEPPLAYIDGKPEGSVRGNIYGTNIHGIFENRALLNRLLNIESGDYRKTMIKNIAATSKLFTGNMNMELLEDLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Q8</accession>
    <name>A0A1V0N1Q8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SoxB-like sarcosine oxidase, beta subunit related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141359.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Q8"/>
    <dbReference type="STRING" id="74969.FAD_0122"/>
    <dbReference type="GeneID" id="31675634"/>
    <dbReference type="KEGG" id="fai:FAD_0122"/>
    <dbReference type="OrthoDB" id="168391at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF287">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="402" mass="43609" checksum="36ED1F9ED6408C0B" modified="2017-06-07" version="1">MASDRHINSVIVIGGGSSGTSIAYNLANRGKKVRLIERGNIASGNTGKSSALVRTHYSNELISSLALYSIREFMNFGNTGYSGFTKTGMVFPFKGSNALEASKNFKMLKSLGINEKEISLKEVKEFFPDISTEGYDYILYEPDSGYADPVATSNAYASAAKNLGAEIVTGKSVKTVSSDNSGAYVETYKGEKYSADAIVLATNTWTNDLLQRSGVSSADLLPIYASVHDTIYLRRPEEYTGIKPTLWDPQNSSYYKMEGASITAIGSLDPAIDTREFDPDGDIENHITDEYIEQYLGKLTDRLPGMANASVISTVSGLYDMSPDGQAIIDSLAGVGLDNVYVCAGLSGHGFKLSPAYGRIVADMLTVNEPEKALFDWRNFSASRFKSKKPIKSMYSGIGTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1R4</accession>
    <name>A0A1V0N1R4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative HTH-type transcriptional regulatory protein FAD_0115</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141353.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1R4"/>
    <dbReference type="STRING" id="74969.FAD_0115"/>
    <dbReference type="GeneID" id="31675627"/>
    <dbReference type="KEGG" id="fai:FAD_0115"/>
    <dbReference type="OrthoDB" id="31424at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00584">
        <property type="entry name" value="HTH_type_cro_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020886">
        <property type="entry name" value="MTH_967-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059051">
        <property type="entry name" value="MTH_967_PDDEXK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26553">
        <property type="entry name" value="PDDEXK_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="306" mass="34579" checksum="0D6D6EC59A3D1EA8" modified="2017-06-07" version="1">MDQRQQLIRDIYDFLKRNDFVVSEPDLYGLVTFDLICRIGDERYILKILYNVNTFSRIGVVPLIKMSAMTGSKTLIIGEKAGNNMLERGVLYFRHGVPILSFESFKDYIAGEPPFIYSAPGGFYVGINGQKMRILREQNNYSIGYIAQKLGVSRRSVSLYESGSSATIDIYLKLESILRGDISRNVDVSISNEEPMPVNAASGFINEVLTVMNNIGYISEYISRNPFDGLSYNSDSHLIIGAFNSVNENTNRIVSIKKISEVLGDIPVLINKENSNKRNIHGCTIISFNELRKIYDVDSFNEFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1U1</accession>
    <name>A0A1V0N1U1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl22</name>
        <name evidence="7" type="ORF">FAD_0163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="4 6">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887168.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1U1"/>
    <dbReference type="STRING" id="74969.FAD_0163"/>
    <dbReference type="GeneID" id="16025312"/>
    <dbReference type="KEGG" id="fai:FAD_0163"/>
    <dbReference type="OrthoDB" id="314984at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_uL22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057265">
        <property type="entry name" value="Ribosomal_uL22_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003260">
        <property type="entry name" value="PRK04223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="149" mass="16768" checksum="B3A3D8E0427D96C8" modified="2017-06-07" version="1">MKGYSIDKMPEKHARAQVKETDISLKDAVNVAHFIRNMDLEAAKNALNLVVEKKMAVPYFRYLDSVSHRKGIGPGRYPVKAVKSFQKLLDDVSANAEFKGLTDDLKIFHISASKGRMIKKFTPKAYGRAGANFKDLINLDIVVIENEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1V5</accession>
    <name>A0A1V0N1V5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable transcription termination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusA</name>
        <name evidence="8" type="ORF">FAD_0204</name>
        <name evidence="9" type="ORF">HLB00_05820</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in transcription termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000196">
        <property type="protein sequence ID" value="NOL60350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887207.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1V5"/>
    <dbReference type="STRING" id="74969.FAD_0204"/>
    <dbReference type="GeneID" id="16025350"/>
    <dbReference type="KEGG" id="fai:FAD_0204"/>
    <dbReference type="OrthoDB" id="4116at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_A">
        <property type="entry name" value="NusA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058582">
        <property type="entry name" value="KH_NusA_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010212">
        <property type="entry name" value="NusA_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01952">
        <property type="entry name" value="nusA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26594">
        <property type="entry name" value="KH_NusA_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NusA-like second KH" evidence="7">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL60350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="143" mass="16718" checksum="7F7CE8DFCBB9190E" modified="2017-06-07" version="1">MNEITLDNQTIGFIKLFESYTRTNVFECLENEEMVLFVVGEHKLADIFKKHENIIADLKAKINKRIVMAEFSPDLLTFTKNLFYRYGVNEINLIWKDNITNIFVGIAPENIGKAIGKDSRNIKLMRDAISRYFKIKNVIIKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1W4</accession>
    <name>A0A1V0N1W4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1W4"/>
    <dbReference type="STRING" id="74969.FAD_0217"/>
    <dbReference type="KEGG" id="fai:FAD_0217"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="105" mass="12273" checksum="4CE5B92E997B2301" modified="2017-06-07" version="1">MNESRMSDQSNINRLIEKARSNTLRDIPVVLVPVWQIKIRERFGINIDREIAEYIVLAVHENGTWKRQRAVRKIEKILIERGNEMPVAKRLAKNILEMAIGNPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Z0</accession>
    <name>A0A1V0N1Z0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FAD_0201</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887204.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Z0"/>
    <dbReference type="STRING" id="74969.FAD_0201"/>
    <dbReference type="GeneID" id="16025347"/>
    <dbReference type="KEGG" id="fai:FAD_0201"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05145">
        <property type="entry name" value="RIO1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR018935">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD84129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="254" mass="29562" checksum="7621DEE457605800" modified="2017-06-07" version="1">MNDKSALKQLIESDEFSNRLNLDRKTYGLVFDRRTLNAIYEVIKKYDIDYIDFPISSGKESLIFNVKLRNGITRALKIYKMSTLKFSNTMEYIKGDYRFDKEKINRSNLVFVWAQKEFTNLQSLRDSGVHAPKPYGFYKNILLMSYLGSSKGPALQIKDLNGGFDEIYVKLREAIWKMYNKAGIVHADLSEYNILYYRNNPYIIDVGQSVSTKHPMALEFLKRDIKNISTFFIKKGVKCDPIELYSYVKGDTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Z1</accession>
    <name>A0A1V0N1Z1_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="3" type="ORF">FAD_0246</name>
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        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
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            <taxon>Archaea</taxon>
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        </lineage>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="74969.FAD_0246"/>
    <dbReference type="GeneID" id="16025409"/>
    <dbReference type="KEGG" id="fai:FAD_0246"/>
    <dbReference type="OrthoDB" id="36101at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="1">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="353"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="443" mass="48785" checksum="255E8182FA994449" modified="2017-06-07" version="1">MIYDILGDSLFNILHQAGEKLKEEKYVRVLAHYDGDGVSSSIILLKALERLDIKYHLSYIKNLDNEGFRSLYEEEADSLNIIVDAGSSQIPAIADHSNFIILDHHFYNKTETSCININARDFGINGTRDACGATMAYIFALALDENNRDLFPFFMSGVMADKQDIGGLSGLNKDLYSEYNSYKTHHTLNLEGTISDAITYSIDPFFDGLTGHPDEVKKFLESNGIDPDKNIIDLTTDENKALGNRLALKILENNVGSDAIKYLEGDVLYFDNLGFSSKELNSIIDGNARIGLQSLPVQYFLGDNSAGNDMVANVKIFKTKLIDYIYRAKSDLKEEKYLRYFYAPESEMAGPIAGAIALYTVKPDKPVIGFNSGTDDVKISSRGSRYSVSRGLNLSEVMKTACAAAGGSGGGHDIAAGGVIPKGREKQFLDAANEMIKSQIKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N201</accession>
    <name>A0A1V0N201_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141409.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N201"/>
    <dbReference type="STRING" id="74969.FAD_0213"/>
    <dbReference type="GeneID" id="31675723"/>
    <dbReference type="KEGG" id="fai:FAD_0213"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="442" mass="49501" checksum="7FA830A8D6C59F7C" modified="2017-06-07" version="1">MNSYKTISDAPSTPFVRKITVLSSMGVMMDGYTLTVFSYALLYLINVMSLKSYEISIMGISSIGGVLIGSLISGYIADIYGRRFIYIYDLFLVSIFIFLTGFATNYINFSILELIVGIGIGADYPVSSSIQAEFSPTKSRGKFMFFNIFSFSIGSLIFLGLAVPLVLFTGVNAWRYMYMIGAVFPILVLFSRKKIPESPYWVQHKYGKEAGEGAKKQFEASTGYTIEGLPDVSREKTRFRDIFKGKYAAYIMFITVAWFSYDIVSYGIWTYSPLIFSTEITSYYADLYVVFTGMAESIPVVVGFLIAIYYVDRIGRRLLLIIGFLGAFAVLILFFFVNQYMVVGLLMTFSAFGFVHFFHNVGPSPITYTYPLEIFPTRIRGTAMGFATSVSRIGSIVAVFSFPIIDALYGLKAIIIFFAIFEFIGLAFTLKYAPETNGKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N206</accession>
    <name>A0A1V0N206_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate-starvation-inducible PsiE family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_081141392.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="InterPro" id="IPR020948">
        <property type="entry name" value="P_starv_induced_PsiE-like"/>
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        <property type="entry name" value="PsiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="113"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="119"/>
            <end position="139"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16753" checksum="AC20E5B142E8B569" modified="2017-06-07" version="1">MEKQFDKKFINIVSLLLRSLLLIAFVAVILHMFIGIYYSVVGAVNSPSSIETYIYSFIDIIVEDSLLAVVIFEIYESVVEFFHGEGDTILYIINGAISFTAREIIVTVFTVHIFRIVNVYEIIGFSILIFALVASRYLLVISGAGKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N220</accession>
    <name>A0A1V0N220_9ARCH</name>
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        <submittedName>
            <fullName evidence="9">Putative serine protease</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
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            <taxon>Methanobacteriati</taxon>
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            <taxon>Thermoplasmata</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NfeD1b_N"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141322">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
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            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
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            <end position="362"/>
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            <end position="198"/>
        </location>
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            <begin position="240"/>
            <end position="361"/>
        </location>
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        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24961"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ARD84200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="436" mass="46211" checksum="C532B0A509CB3E3E" modified="2017-06-07" version="1">MTKPKGLIIVLIIFIFLLMVASSAGHATGPAENSYKAGNGKVVLFINLTGTVSAGTTNMFRSELANIDNSSVKAVIISVDAGGGMLQQALDIDKYINSTENKGITVYAYVLPGGSATYTATYVTMDATGLYMAPGTMIGLSQPDLVGGTSTQEQNDIIQMGHVMESMALAHNRNGTAASSMVLNDSEYSSTQASNIKLSDGNFASMNAMLVGLNLSAYGKEYVHQSVYDNFLGFIANPLIAGIFILIGIVAVFLDLYHGTIVLSVIGVVMIGLGLLGADIINASVFGLILLLLAGILIFLEFKTNHGIALLSGLITGIAGIYFLASSYGTSSPGYSPAPFGESFYMFSIAIILIGILLIIYISKILKSQRREIYTGAESLIGHSADVVTPMKRNGKGFVMIDGVQWEAINIGVDVNRSEKVVIIERKGLTLIVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N227</accession>
    <name>A0A1V0N227_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N227"/>
    <dbReference type="STRING" id="74969.FAD_0234"/>
    <dbReference type="GeneID" id="31675743"/>
    <dbReference type="KEGG" id="fai:FAD_0234"/>
    <dbReference type="OrthoDB" id="385154at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="445" mass="49729" checksum="20A1A5991005A471" modified="2017-06-07" version="1">MKSVNLRGAVMQSFTSIGPMLDFIALFSIISAYSGSMLPFVVIFSFLLSYFTLYTIYSLSRIYVTNGGYYSYVGNALGRGAGFFVLLLYIIYSVLTVPNISLFISGFSYSILELAGFTAPVLKYVLLLIFIGTVYYVVSRGLKVSITYTLIAGFLEIAFIILMSIIFIIYRSPGFSFSGINFSFNPFFFGVIFGILAFSGGGSSIFISEQTASSHINTPKSLFLSFTISGIIMAVSAFALLMFAGFAGLRAYESNSFYITELVQARLGTPFLILFSFFGIMSAFNLSVSYLNAFVHMVPKFYHDFNLKGEFNRNKLIAILSVTSAGIAIFSGYYGGFFNSFVIIAGIISFVYIIIHIISNISLIKIFRRKKFFMPVLSSIILTIAFILSFSGNTGYYAVINYFLIGFIMISAFIVILVRKIIPRFYMAIRFEYYARINELPEHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N232</accession>
    <name>A0A1V0N232_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887237.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N232"/>
    <dbReference type="STRING" id="74969.FAD_0229"/>
    <dbReference type="GeneID" id="16025382"/>
    <dbReference type="GeneID" id="31675738"/>
    <dbReference type="KEGG" id="fai:FAD_0229"/>
    <dbReference type="OrthoDB" id="57073at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40933" checksum="5C42E9E4C9BFAA9E" modified="2017-06-07" version="1">MDELNLINRLNRGISYIGIAIAVLGFFFTIPFLIKDINSIIGVSGSYFYLHITVTSNLAYIFLISGIIIVLASFTPFIYNSTKFASFDIKNNEYYFSALAVYMALLVFSSVIIEVFDPSIAVSPVSKMPLGEQNFIYLMSSVFQVLIFEFIPITILIAIILLATKKFKFSSFLNPYGHVKEYLIVFMILPAAVAVLITNYNIYDSILIYLSTLALSFIYIRYGLLRSVFASFVSSFIEFALTAFAGNVIVSSITSVFIFIWAFLGLYTVTFYIVDRNRKASRERGTDEPAQSGEPNTAAKIQPRIKTPPDELWIRSACPNCGNVEYRIGPDMSLECTKCGQKLDKDYTGPYNIIINNIIGRRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N237</accession>
    <name>A0A1V0N237_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0276</name>
        <name evidence="4" type="ORF">HLB00_06440</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000224">
        <property type="protein sequence ID" value="NOL60470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141446.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N237"/>
    <dbReference type="STRING" id="74969.FAD_0276"/>
    <dbReference type="GeneID" id="84218774"/>
    <dbReference type="KEGG" id="fai:FAD_0276"/>
    <dbReference type="OrthoDB" id="56239at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071713">
        <property type="term" value="F:para-aminobenzoyl-glutamate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046657">
        <property type="term" value="P:folic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="165"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="387" mass="41890" checksum="305B8BC111CC54C6" modified="2017-06-07" version="1">MDIDSIIIQHKNSILSISDKIYNFAELGSREYKSSTLMMDELKKEGFTIVNPYMGMDTAFRAEYGVGSPVVGILMEYDALPNGHSCGHNLISAWAYGTAIVLKNFISSGKIVVFGTPSEEGIGPYAGSKAIMAKSGAFNNVDFVIGMHPDDRWAVGSKALADSEMEFIFHGRSAHMAASPCYGINALDALVTTYSAINNMRDLAKGDKNIVVGMVIRDGGKASNVVPDRAAMEVDLRSSDSSFLVEFIEKIKKLAKGISDGYGTTLEIKDLMPMYTEYKANRVIDGVLYDELEKIGIDAFNIDDSDESASGSTDEANVSLAVPTGHIDLKIGTGLPGHSDQFREAANPARAGENLIIAIRAASSAILKIMQDKQRLNKIKEEFDNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N250</accession>
    <name>A0A1V0N250_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141434.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N250"/>
    <dbReference type="STRING" id="74969.FAD_0265"/>
    <dbReference type="GeneID" id="31675774"/>
    <dbReference type="KEGG" id="fai:FAD_0265"/>
    <dbReference type="OrthoDB" id="56009at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21311" checksum="2192FBACD6F3DA1C" modified="2017-06-07" version="1">MAKVSDSVKVIVSNSLIYSMAISSGLCNYTKIAENIKDKVEAMTGKNVKFNTIVKVLANMKTEKPEYTDDLEILKRSSLTIEYEYSILYFDDIKKIPENSILVMKESNIYICIANTGNQQSKIALIKIILPKQSSFTPGLTLLITDYLMTYGIKFTNIYRLDTEIWIIIDNSNAGKALYRLSTLLHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N253</accession>
    <name>A0A1V0N253_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase</fullName>
            <shortName evidence="6">PvlArgDC</shortName>
            <ecNumber evidence="6">4.1.1.19</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit beta</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit alpha</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="primary">pdaD</name>
        <name evidence="7" type="ORF">FAD_0310</name>
        <name evidence="8" type="ORF">HLB00_04590</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-arginine + H(+) = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="6">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PdaD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000157">
        <property type="protein sequence ID" value="NOL60113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887330.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N253"/>
    <dbReference type="STRING" id="74969.FAD_0310"/>
    <dbReference type="GeneID" id="16025476"/>
    <dbReference type="KEGG" id="fai:FAD_0310"/>
    <dbReference type="OrthoDB" id="30748at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:L-arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="entry name" value="Pyruvoyl-Dependent Histidine Decarboxylase, subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01404">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00286">
        <property type="entry name" value="pyruvoyl-dependent arginine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438:SF1">
        <property type="entry name" value="PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005216">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00055">
        <property type="entry name" value="Pyruvoyl-Dependent_Histidine/A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="Pyruvoyl-dependent histidine and arginine decarboxylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_5044508777" description="Pyruvoyl-dependent arginine decarboxylase subunit beta" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044508778" description="Pyruvoyl-dependent arginine decarboxylase subunit alpha" evidence="6">
        <location>
            <begin position="42"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic)" evidence="6">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="6">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="179" mass="19729" checksum="31AAE475A1655F91" modified="2017-06-07" version="1">MLLPKKIFFTRGIGRGETQLQSFENALRDADIAAYNLVSVSSILPPYAEIVDKSEGIKLLSYGQILFTVLARNSSNELNRMISSAIGVAVPSDRSKWGYLSEHHTFGQTENDSGHFAEKLAAEMLASTMGLDDHLKWEDKKNEYVLDDKILTTKNIAATTVVLKPDEWATVIAAAVLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N271</accession>
    <name>A0A1V0N271_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N271"/>
    <dbReference type="STRING" id="74969.FAD_0330"/>
    <dbReference type="KEGG" id="fai:FAD_0330"/>
    <dbReference type="OrthoDB" id="6486at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002252">
        <property type="entry name" value="PRK01175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="248" mass="28084" checksum="9CE0845CD0101290" modified="2017-06-07" version="1">MEGTNNEEEAFLSLRRSGFESEYVHVSEIGKKKFEDYDLLFIPGGFSAGDYVRAGAIFASRLAPHINELNKFVDSGKILIGVCNGFQVLSELGMIPDTGTERKRTMVLGTNDSDRFECRYTYIKYTSKNKIFRRHFEGKILQVPVAHMEGKVIFDSKKTLDSVIENDQMIFQYTDINGTDSSYPWNPNGSVMDIAGLTNREGNVIGLMPHPERVYYGFQMMNDGNKHKNGTGEVFFNSLYEYTKKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N284</accession>
    <name>A0A1V0N284_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nop1</name>
        <name evidence="7" type="synonym">flpA</name>
        <name evidence="8" type="ORF">FAD_0282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141452.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N284"/>
    <dbReference type="STRING" id="74969.FAD_0282"/>
    <dbReference type="GeneID" id="84218781"/>
    <dbReference type="KEGG" id="fai:FAD_0282"/>
    <dbReference type="OrthoDB" id="6244at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="220" mass="25336" checksum="D8C723314869D9E8" modified="2017-06-07" version="1">MKKHAQPLQINNRRIVNDRGKIFTVSGFNQSIYGEKIKKSGGFYLREWNPRRSKLGAALLKGFKSMPLKEDSSVLYLGASTGTTVSHVSDICFRGMVFAVEFSYDSFVKLYTLAEKRNNIYPILEDANLPEKYEFLIDGPDVIYQDIAQRNQIQIFNENSKKFKNAEKAMLIIKARAISSNRPEKSIVNSAIREIKDFKVKEIIDLKPYDIGNYFVYLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N293</accession>
    <name>A0A1V0N293_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-1-phosphate dehydrogenase [NAD(P)+]</fullName>
            <shortName evidence="11">G1P dehydrogenase</shortName>
            <shortName evidence="11">G1PDH</shortName>
            <ecNumber evidence="11">1.1.1.261</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Enantiomeric glycerophosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">sn-glycerol-1-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">egsA</name>
        <name evidence="15" type="ORF">FAD_0289</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sn-glycerol 1-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sn-glycerol 1-phosphate + NADP(+) = dihydroxyacetone phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycerol-1-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.261" evidence="11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887311.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N293"/>
    <dbReference type="STRING" id="74969.FAD_0289"/>
    <dbReference type="GeneID" id="16025458"/>
    <dbReference type="KEGG" id="fai:FAD_0289"/>
    <dbReference type="OrthoDB" id="8656at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106357">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106358">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08173">
        <property type="entry name" value="Gro1PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00497_A">
        <property type="entry name" value="G1P_dehydrogenase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023002">
        <property type="entry name" value="G1P_dehydrogenase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002022">
        <property type="entry name" value="PRK00843.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="GLYCEROL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616:SF5">
        <property type="entry name" value="GLYCEROL DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD84211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="350" mass="37627" checksum="DA2D8A2D92381475" modified="2017-06-07" version="1">MEFNKTKAMHFPNDVYIGHNAIDSMRIVAEKNLKSGTILVITGQKTYRIAGEAVVNKLEGLKHYVLFSGNATMDAIKSAREEIADIKVGLVIGVGGGSKIDMGKKIAFDLNVPFISFPTAPSHDGIASPRASIYDGKSFLSIEAAMPTAIVADTEIMAKAPYRFAAAGASDVIANITAVMDWKMANRIKGEIFSTTAAVISEYSSRELIENANMIQPGLEASIWMITKQILASGTAMAIAGSSRPASGSEHLFAHALEILGSGNAMHGEQVAMGSLVSMYLHGGDWKMLYDTYKKIGVSTKAKDYGIPDEIAIKALSIAHRLRPQRYTILGETDLNEEVSRNALKLTGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2A5</accession>
    <name>A0A1V0N2A5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp 20 family small heat shock protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0299</name>
        <name evidence="5" type="ORF">HLB00_04290</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000147">
        <property type="protein sequence ID" value="NOL60053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141468.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2A5"/>
    <dbReference type="STRING" id="74969.FAD_0299"/>
    <dbReference type="GeneID" id="84218799"/>
    <dbReference type="KEGG" id="fai:FAD_0299"/>
    <dbReference type="OrthoDB" id="198277at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041799">
        <property type="entry name" value="Hsp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="126" mass="14779" checksum="476C4F624A47E250" modified="2017-06-07" version="1">MYRPLKYYSDEFMKNINNRAKEIMTFMYPPVTMYEDNGYIGIEADLPGFSREDIKVTLEKNAIVIRAEREIKPEGTVFENQRPEKVFKRMSLPMEVDTEQEFSAKYNDGVLSLKIPVKNVKTVKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2A6</accession>
    <name>A0A1V0N2A6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
            <shortName evidence="6">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">serS</name>
        <name evidence="11" type="ORF">FAD_0347</name>
        <name evidence="12" type="ORF">HLB00_01460</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000040">
        <property type="protein sequence ID" value="NOL59505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887366.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2A6"/>
    <dbReference type="STRING" id="74969.FAD_0347"/>
    <dbReference type="GeneID" id="16025512"/>
    <dbReference type="GeneID" id="84218845"/>
    <dbReference type="KEGG" id="fai:FAD_0347"/>
    <dbReference type="OrthoDB" id="35932at2157"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="159"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="7">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL59505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="443" mass="50994" checksum="6E171CE63E9CFCB1" modified="2017-06-07" version="1">MIDIKLLRSDKERFYNSCRARGFDLNILDEFFSLDLKWRENLKILNTYKHDKNIITADISSLVKKGENIDNLKLEVEKINKKISLLEEEQNDIESKRNELARLIPNLLAEDVPICKGDENSKLVRYVGNARVFKDDIENFREGSGNSKDYTVIDKKPVDHQTLMEKYNLADIERAGKIAGSRFYFLKNRLFKLELALINYGVDFLSQRNFTVMEPPFMINYASMSGATDIETFKESLYKIEGDDLYLIATAEHPLASMLSGEILEESELPLRVSGVSPCFRREAGAHGRDTKGIFRVHQFNKIEQFIYCRPEESWDFFDELVKNSEDIYKSLGLPYRIVNICSGDLGSLAAKKYDIEVWYPSQGKFREVVSASNDTDYQARSLNIRYRAKDGNKFAHTLNSTAIATERVLVAIMENFQEDDYIKVPDVLVPYTGFSRIGMDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2D8</accession>
    <name>A0A1V0N2D8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0346</name>
        <name evidence="5" type="ORF">HLB00_01455</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000040">
        <property type="protein sequence ID" value="NOL59504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887365.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2D8"/>
    <dbReference type="STRING" id="74969.FAD_0346"/>
    <dbReference type="GeneID" id="16025511"/>
    <dbReference type="KEGG" id="fai:FAD_0346"/>
    <dbReference type="OrthoDB" id="34502at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049142">
        <property type="entry name" value="MS_channel_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221:SF1">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21088">
        <property type="entry name" value="MS_channel_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="Mechanosensitive channel protein MscS (YggB), transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel transmembrane helices 2/3" evidence="3">
        <location>
            <begin position="95"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="2">
        <location>
            <begin position="137"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="393" mass="43513" checksum="3B1A51907BC28E74" modified="2017-06-07" version="1">MAIDKHKLGKMRNEVLKIVVEVIIGIVLALLAGFAIDIVINKFLPQYKSYQPFIVEAVHAVIILIIGFLVVGSFLKYLKEALIKTNRSLYGVSLIIRIVFYIIILALVMSAFHISVTGILAGSAIGGVVLGLAVQTVASNLLSSIFATSTNTIKYGEVISVNSWVWSIETTGKIIDVKTLFSQMLTKDNNIIYLPNSEILGNSVITEFRTKNGSYTYPLNITVQADVPADQILSQIKENNDFSDIKFFLSTKNGVSNTFEALIVFNEVTELNEKIARANNALDSAYWNIKSKFNVLGPNAMWESPENVYPLTVTLNSDVPSEKLIDEAIKQIPNSEVILLTRGASTNVYLAKVKIAGKEVDKVINDTNLSFERIYNKLKADNDNTHKDDTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2E0</accession>
    <name>A0A1V0N2E0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141508.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2E0"/>
    <dbReference type="GeneID" id="31675844"/>
    <dbReference type="KEGG" id="fai:FAD_0334"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="358" mass="41064" checksum="F457B9D3336DD78F" modified="2017-06-07" version="1">MDENDLNELKYIFSYLVDSFSYEVERDKKSGEIENMTRMLENDKKAIDKMKKGMRENMDEFVVIYNDFKVNEEKIMDYISSVTDQYYTKHSQDILSTISQLQHETENYIENGVKAMNQFFSLNPLTILNSSIEISAGKDAFDIRQSIQSSYGISYIFSLEPALSQFMKNPYFSSLYTGIKIPVLIAGDGSVNYENLDSYKLSGAKLSENILDCSFYNETSGNFIDFKYKISGPDIEIVFANNGEKVKITDNPDFMSHMDVKIMDDALGKLANEITGLTGKDRHLVSLKIDGEEILTTMSFEKIFFRIIKSDYIKSLVKELPENCENCENPDSISKELIRHRIHIIGKDEDYILSTLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2K7</accession>
    <name>A0A1V0N2K7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0405</name>
        <name evidence="2" type="ORF">HLB00_05040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000171">
        <property type="protein sequence ID" value="NOL60201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887437.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2K7"/>
    <dbReference type="STRING" id="74969.FAD_0405"/>
    <dbReference type="GeneID" id="16025583"/>
    <dbReference type="KEGG" id="fai:FAD_0405"/>
    <dbReference type="OrthoDB" id="129677at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8424" checksum="9D9201B4EDB25073" modified="2017-06-07" version="1">MKTFLKVIFNSEGTKPSEIVGRLRSLGFSLIKGEQDMVYEWPDSATADDAIWFADKIQATLQGFNVYFEIETLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2L2</accession>
    <name>A0A1V0N2L2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141628.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2L2"/>
    <dbReference type="STRING" id="74969.FAD_0486"/>
    <dbReference type="GeneID" id="31675995"/>
    <dbReference type="KEGG" id="fai:FAD_0486"/>
    <dbReference type="OrthoDB" id="53394at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="121" mass="13828" checksum="4CF31BA987FECD33" modified="2017-06-07" version="1">MHGNKKIIWLIIGLAIFVVALSMVSFFLYGRPDIATRYSGVYPSATGFPGRFAFIIMPVMAIISILILILFVRFIMRMAGGSSCRRDMIYDNSEAILRERYAKGEISEEEYKTRLNNLKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2M9</accession>
    <name>A0A1V0N2M9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-5' RNA ligase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141593.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2M9"/>
    <dbReference type="STRING" id="74969.FAD_0439"/>
    <dbReference type="GeneID" id="31675948"/>
    <dbReference type="KEGG" id="fai:FAD_0439"/>
    <dbReference type="OrthoDB" id="383452at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13563">
        <property type="entry name" value="2_5_RNA_ligase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20798" checksum="EB6C7430C6A858B9" modified="2017-06-07" version="1">MQYTLILKPSLSARRKITAKKKRLEKLYGYTGSLSNKGVHITMAYLRNSRFLDVNPIITLCGKTAPFTYEIGEVGYFEKVRKGKISYIVFLNVIPSPEMYEFHEGLIKALGDNTTEVGKFIPHITLIRKNVNENNLNEIVKFCENLKIDCKFLSTYLILGKRSSEYSRWHFEHIDFHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2P7</accession>
    <name>A0A1V0N2P7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Spt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpoE</name>
        <name evidence="2" type="synonym">spt4</name>
        <name evidence="4" type="ORF">FAD_0460</name>
        <name evidence="5" type="ORF">HLB00_10005</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of Spt4 and Spt5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Spt4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000442">
        <property type="protein sequence ID" value="NOL61150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887513.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2P7"/>
    <dbReference type="STRING" id="74969.FAD_0460"/>
    <dbReference type="GeneID" id="16025662"/>
    <dbReference type="GeneID" id="84217043"/>
    <dbReference type="KEGG" id="fai:FAD_0460"/>
    <dbReference type="OrthoDB" id="275101at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00949">
        <property type="entry name" value="Spt4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007178">
        <property type="entry name" value="Spt4_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038589">
        <property type="entry name" value="Spt4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041664">
        <property type="entry name" value="RNAP_arch_Epp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="3">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL61150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="63" mass="7158" checksum="FF56F1AAB52172B0" modified="2017-06-07" version="1">MKKAYKACKICKRLTTEDVCPVHGEERTKVDWFGFLIINDINSQIAQKAGITEKGIYAIKVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2P8</accession>
    <name>A0A1V0N2P8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP-dependent dephospho-CoA kinase</fullName>
            <ecNumber evidence="6">2.7.1.237</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-coenzyme A kinase</fullName>
            <shortName evidence="6">DPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3'-dephospho-CoA + GTP = GDP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="2.7.1.237"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GTP-dependent DPCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.237" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887512.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2P8"/>
    <dbReference type="STRING" id="74969.FAD_0459"/>
    <dbReference type="GeneID" id="16025661"/>
    <dbReference type="KEGG" id="fai:FAD_0459"/>
    <dbReference type="OrthoDB" id="15447at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00590">
        <property type="entry name" value="Dephospho_CoA_kinase_GTP_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007164">
        <property type="entry name" value="GTP-dep_dephospho-CoA_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732:SF1">
        <property type="entry name" value="GTP-DEPENDENT DEPHOSPHO-COA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732">
        <property type="entry name" value="UPF0218 PROTEIN TK1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04019">
        <property type="entry name" value="DUF359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006533">
        <property type="entry name" value="UCP006533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="168" mass="19180" checksum="30A081BD4E22CF82" modified="2017-06-07" version="1">MPLKLDRNIVIGSRERKYIQDFKYSLCSVDDIRELALKNKIISVGDVTTENLKNAGIKLNLQIVDLVTKRDGKRFMHEEGSITVSNPPGIISIDLMNKIYEFISTGVHGRIEVDGEEDLAVIPIIFYADKNTVIVYGVPDVGMAYIKVNDEIKERIKEMIMEMYRNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2R2</accession>
    <name>A0A1V0N2R2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0519</name>
        <name evidence="2" type="ORF">HLB00_00550</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000014">
        <property type="protein sequence ID" value="NOL59329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887577.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2R2"/>
    <dbReference type="STRING" id="74969.FAD_0519"/>
    <dbReference type="GeneID" id="58788986"/>
    <dbReference type="KEGG" id="fai:FAD_0519"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="53" mass="6263" checksum="968D743A76B7D172" modified="2017-06-07" version="1">MYNKDSKTKTGYNLKGILRKISFNREIEKALTEDRYCKDTALVYFERLEGKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2R7</accession>
    <name>A0A1V0N2R7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887586.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2R7"/>
    <dbReference type="STRING" id="74969.FAD_0529"/>
    <dbReference type="GeneID" id="16025735"/>
    <dbReference type="GeneID" id="31676036"/>
    <dbReference type="KEGG" id="fai:FAD_0529"/>
    <dbReference type="OrthoDB" id="358920at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="212" mass="24417" checksum="42CCC66D5A3592F2" modified="2017-06-07" version="1">MHLLIVGSEGRLGRTLMKIFPGSSSIDLENEDQLQSELTKADFALLAVPLEETVNIIRSFPEYRGFVDLTSMKYNMEEFSGHIISIHPLFGPESYKTNKTIIFINDISTPDSLDKVKELFNGYRIISMNAREHDYLMSELLVKPYILSYISEASNTDIVTGSYIKFLEIEKIKHNENTEIFLDTIKYNERAMEIIINIEKKLDELKKLIGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2U1</accession>
    <name>A0A1V0N2U1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Segregation/condensation protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141682.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2U1"/>
    <dbReference type="STRING" id="74969.FAD_0551"/>
    <dbReference type="GeneID" id="31676057"/>
    <dbReference type="KEGG" id="fai:FAD_0551"/>
    <dbReference type="OrthoDB" id="53244at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29674" checksum="59258B5146878DD5" modified="2017-06-07" version="1">MERDEILKALITQDVGEDLSYYNEILNSTEDNIDYPDILSQTVSKIFRLVLTGKLDPWSVNISEFKNIFAREKNENFEIAGILISSAWHVLYEKSIYMVQRAIYEDPDSPEEYAEPEDGMDIFNTDDTTIGTMPDLRVPVIHQEEAKVTLKEFLSAMKSVYRNSEKKVVEEEPEDIPDIDEDIIARSNTDAVDEGIKDTLQKISHYMNPFFVEDYWGNTKYERANFILFLLFLERGGKVTLNQEEPFGNIEVIKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2V1</accession>
    <name>A0A1V0N2V1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0503</name>
        <name evidence="3" type="ORF">HLB00_09595</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000426">
        <property type="protein sequence ID" value="NOL61070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887561.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2V1"/>
    <dbReference type="GeneID" id="16025707"/>
    <dbReference type="KEGG" id="fai:FAD_0503"/>
    <dbReference type="OrthoDB" id="114121at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02238">
        <property type="entry name" value="cupin_KdgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052535">
        <property type="entry name" value="Bacilysin_H2HPP_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025499">
        <property type="entry name" value="KdgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112:SF1">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029883">
        <property type="entry name" value="KdgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL61070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="118" mass="13695" checksum="C9481BF4749E19D2" modified="2017-06-07" version="1">MAEIVKYRWDNVKKEKLSETFYRQMVYGDKVMVAQLDIRKGSIVPEHSHENEQITWIMKGKLHFKIGGKEMDVGAGEVLIIPSNTKHEAIALEDTLDIDIFSPRREDWISGTDSYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N300</accession>
    <name>A0A1V0N300_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951097.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N300"/>
    <dbReference type="STRING" id="74969.FAD_0607"/>
    <dbReference type="GeneID" id="31676112"/>
    <dbReference type="KEGG" id="fai:FAD_0607"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1168" mass="136977" checksum="BA3106A89DD25390" modified="2017-06-07" version="1">MIAVERLMVRKKLKTMLKKSIEKNNIDIFTGFIIKEKNAIREVYDTQISDILLNALRDAEISADLYSALTYIDDKSPLILEYKALKLYSDGKIDDFIHFVTSNIDILSLANVKKDFDELINKSQPEKAVEYLSIAGVFDEGIFKEYFATMPGEQEIRRLTALFQTNGSINDLEKILSICISKIPYSTCYFSLADIYVEFNQKDKLKELLHDILKNRIHYNNIDIRKYYSYLGEYEKVVEFSDVNEPDNALLADAYYHLGYYENALKIYKYIYYNEDKNVLERIIDITYAIKDYYSLINYINLIEKNLGTNKKLLLYKIESEIVLDLYSEAELDLNRYRSNFGDDTEVLELFAKYFRAVDNQEMLYKIAIQLIEKGNTDHENYRIIVNYLYENQEYSKILSYVTEKNLINEFKPEYCSSLIYLNRIEDAIEIITTERSLLDSGRVVDGIFEKIKTNENIRKFNSINKQGTILEMVISYMQGRKNFDYMKYAGKVKNAGSLAGIYILATSTRKDNFFDRRYIRNLLDIDRYQIISSILSNIESIKNGEDIGDMNDSRYFLYPITKALIKTKRYHEASTILDSLYSKDPDAFYYYFRAYIEFQDSNFGDAIKHVEEAISVLDNVDFLALRINIALAKNTNAETYTKSAIDLGFTDIFGMIYNFVVSRNIDVSEEFREYLEKIDIKNVYLYRLKSYCLRDYKSVLKYSALSLLYGGNSEDVVNHYSILKKDNELTAVYFLEHYKNKYYEGYIILSSYYYSKRILKKSLEYFNLAYVRNSIAVKNPLFQELFMGVPLSSAIINAMESTGEWFHLMVYYYNRKEFGKVREITQYHYNNIKIPEFLITRAWENMPVKTFMVGLFNKSHDKILGELLANKFDELELYEDEIDILKTLISYYPDENILFERLINSLIQNGNLNEALETTYDRFHEKKDISSFNRMVHIFYDLRDYSSLANIFNNNREFVNAENIKYWIYSQIKLFNYAATRALMHDYHGIINVDTSESINSKLRSSYRTRMIVEVTKKVFDTEYVDQKVSQPAELSAMVPAYLANDVYEFITNKEPYSYIDAKEYNNESVNIIGRLNTIGISDIRDIKIYHIYKVTGNVIKSKNFYIFIKRCMEGYYKIEKLSENGGSINSGDMGNEPDIIKIITKYNVGLMDAIYIAGKMKNGMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N319</accession>
    <name>A0A1V0N319_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141683.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N319"/>
    <dbReference type="STRING" id="74969.FAD_0554"/>
    <dbReference type="GeneID" id="31676059"/>
    <dbReference type="KEGG" id="fai:FAD_0554"/>
    <dbReference type="OrthoDB" id="358785at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42731:SF4">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42731">
        <property type="entry name" value="SLL1084 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="205"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="540" mass="60930" checksum="F4F6D64164F7B2E3" modified="2017-06-07" version="1">MAKVILTSDRGTFTDYGGVSVLGYVACMPNNIVPKLLMDKFFAPPAKYNRGEPLHVPYPLRKIEASLVNAGISDIKIVSPERLEKEVNEDTKVVGINVHDPYGLSPVTFKLTMLFGGQMSWTARYFEELADVVRKLKQKYNFRVIVGGPAAWQIGLNKPDFVDTIFNGEAEIDFPVLVKKSLDGESLPAEITGRMPDITHIPNIIKPGRFGEVQVTRGCPRGCSFCSITPETYRTIPMENVEAEASLYLKNGYKDIEFITDDIMLYGQKKLTVNHDAIVNLFSTVKKMGARYLTFPHISAPAVLVSPDTLFEISEIGGLKEYGAEAPVVGLETGSTKIMHKYMNAKPYPWKPEDWKDVIVKATSIMNQASVFPCYTMTIGYPEETEEDLQQSIDIVQSIIDSNYTAWIFPLPVIPMTSSRISKNPFPYMEKLPAGYWDLLYEAWKYDFRTTKQVIPNMVKRMNPVTRRIIDLMNDAVFDNLDKIFKQLAETKGKKSADFTDINMNTVTGFLKTVYWITRYTAGKEIKNKKVSSLTNEARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N325</accession>
    <name>A0A1V0N325_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase D-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141741.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N325"/>
    <dbReference type="STRING" id="74969.FAD_0642"/>
    <dbReference type="GeneID" id="31676146"/>
    <dbReference type="KEGG" id="fai:FAD_0642"/>
    <dbReference type="OrthoDB" id="56599at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09128">
        <property type="entry name" value="PLDc_unchar1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase D-like" evidence="4">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D-like" evidence="4">
        <location>
            <begin position="194"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="318" mass="36010" checksum="CB72E4A09A086FEB" modified="2017-06-07" version="1">MSYKVYVEPDDGVKPFVNLIKKARRFVYINSYLLDEPEILKAISDAVKRKVDTRLMVDGRPYGINGSDGTHAEIDNLRKTGAKVKVAPERFEKPNVFDHAKYMVSERQAEVGTPNFTEAAFSSNREYFTITSDKKIIKSLKTIFLADFENKAAGEMPRKYLIVSPGSEKALGDFISRERKLLIETEEMGDDKEILKVLMDKGRKVKLIVPSSISSTDIDDIKQLKKHGVKVKYMPANKLYMHAKMIAGKKIFIGSENFTRSSLNRNRETGIILSGLLKTSRLKNTFASDWRKARKSLKLARATTSSKNKRYGVKKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N332</accession>
    <name>A0A1V0N332_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CobN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141711.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N332"/>
    <dbReference type="STRING" id="74969.FAD_0585"/>
    <dbReference type="GeneID" id="31676089"/>
    <dbReference type="KEGG" id="fai:FAD_0585"/>
    <dbReference type="OrthoDB" id="192131at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119:SF7">
        <property type="entry name" value="MAGNESIUM CHELATASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="MAGNESIUM-CHELATASE SUBUNIT CHLH, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobN/magnesium chelatase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1136" mass="130030" checksum="37F6B715EB88E655" modified="2017-06-07" version="1">MKFAVLIGWNGSVIQSFLHAGEETGNEIKIKYPRLDPVDKEFIDFVRDADAVFIHHFSGENIYSNILEDIESVIKGKKNVIAIDPILSNYSTVSKFVEEKVSNYYFYGGYENIKNMVLFIENTITPRHYEEPVEMPFSGIYEYGNTEFPKKVGILFYRTAWVDRDTKIIQYIIDNLNNNKISAIPVFTNGFGDRSRGIMSAEECINTYFYSDGKPVVDAVINLLSFSLIKKEDKSTLMNLGVPVFQGLIYYYKEEKEWLDSSGLDVVSTIMSAMLPEMDGTIEPVLIGVIKKIYDRGTIYRELVPVKEQAQYMINRIRKWVNLRYMKNSEKKIAIILHSGSSFKDLEANIGTATGLDTLNSVSSIMSLLRENGYNMDYLPENGESLIKTIMEKKAIPEGKWTPVEEIINKGGSVYGMPVKEYMKFFRELPEDSQDMIIKRWGELNTERDYMLLNGTMHIPGIISGNIFIGIQPKRITFADNDNSIRSIHDSLTPVTHYWLAFYKWIQEIFRADAIIHVGTHGTLEFTPGKGLGLSPSDFPEISIGEIPNLYLYSTNVPGEGIIAKRRSYAVLLDYITPPTAYDDVPDDIKELEDLIDDYEETEKAENTSRETMILEKIQKISDKIGLSIDFKDAHKATHEIEHRLNLFKDSIISKGLYIYGKDIDKDDLKDYVTTATRFDESLSKKYGKEEAENQIMAYLNEGTPIPELETGIIEKLKFSPENEKNNLLMALNGKFIEPGVSGSLTRGRYDVLPSGRNFYAVDPFKIPSHSAWQVGVILANKLIENEYKKNNKFPETIGFVLWSTDAYRSDGELISQILYTIGVEPVWQEGTKKVKDVKPIPLDVLKRPRIDVVVESSGIVRDNLFNIIELIDLAIKKVSELDEDDDVNFIVKHHKKYGHLDRIFSSKPGSYGSGVNNAIESSKWENENDLADVFTEWMGYSYGKNNFGRESKDELLSISKDIETIIHKREIDEIDINDDSCNYSYAGGFYLMAKKSGSKPSLMFEDTFNPNKPQVRTMKEEIERTAIGKLLNEKWIEAQKNFGYRGATEMLKKIEHLYGWGATTGMVNDNIFNNIANKFVLDREMKEWFKKENPWALSEITSRMIEAYKRDIWHASDSMKEQLEEEYMEIEGENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N352</accession>
    <name>A0A1V0N352_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NAD(P)H-quinone oxidoreductase subunit 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ndhC</name>
        <name evidence="8" type="ORF">FAD_0618</name>
        <name evidence="9" type="ORF">HLB00_04675</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000162">
        <property type="protein sequence ID" value="NOL60129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887676.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N352"/>
    <dbReference type="STRING" id="74969.FAD_0618"/>
    <dbReference type="GeneID" id="16025825"/>
    <dbReference type="GeneID" id="31676123"/>
    <dbReference type="KEGG" id="fai:FAD_0618"/>
    <dbReference type="OrthoDB" id="9823at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005022">
        <property type="entry name" value="PRK06432.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058:SF9">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL60129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="144" mass="16748" checksum="98F06F9AEE8FFF33" modified="2017-06-07" version="1">MILGYASIVITIIILVLALYLLFKVLPTIGGNRYKKGGIKFNRKEIARNISLEDNPPAEDDSYLQPYESGEVAVEYAEGHITVQYYVIIFLFILFDIDMLLLFPWAFDFYALGIIPFIETLIFMAMPLFVVFYAYKKGYMRWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N355</accession>
    <name>A0A1V0N355_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S2P/M50-1 group multipass membrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141723.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N355"/>
    <dbReference type="STRING" id="74969.FAD_0606"/>
    <dbReference type="GeneID" id="31676111"/>
    <dbReference type="KEGG" id="fai:FAD_0606"/>
    <dbReference type="OrthoDB" id="86131at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052348">
        <property type="entry name" value="Metallopeptidase_M50B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35864">
        <property type="entry name" value="ZINC METALLOPROTEASE MJ0611-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35864:SF1">
        <property type="entry name" value="ZINC METALLOPROTEASE YWHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="6">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="204" mass="22101" checksum="B39E9240314D5CFB" modified="2017-06-07" version="1">MMYNRNNEGNDIIIAVIVLTIAFTLMINGGLRGVPDIKTLEIEVLIGFSVTVTAFLMHEMAHREVARRLGAVAFFKLWPVGILLALITSVFGFIFAAPGAVQFAGLYDRDSEGKIALAGPGTNIIIGVIAFLAVTFSGITGVASTILIWVAWLNLWFALFNLIPFPPLDGSKVFYWNSKIFAGVFLLAIILNIVDGFLPAILGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Amino acid transporter</fullName>
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    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
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    <reference evidence="6 7" key="1">
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            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
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    </dbReference>
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    <dbReference type="KEGG" id="fai:FAD_0636"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052962">
        <property type="entry name" value="AA_Transporter_AGT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47547">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47547:SF1">
        <property type="entry name" value="ASPARTATE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="344"/>
        </location>
    </feature>
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            <end position="369"/>
        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
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        </location>
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        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
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        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ARD84547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="568" mass="62050" checksum="9D8887D77F9900C1" modified="2017-06-07" version="1">MVGSGWLLGVLAGPAYAGPASILTWVVAGVFFIILALVFSELGTLFPYSGSLVRFNEFSHGPVSNFYLGWAYMIGAIATPPVEAAALTGFISSYVPGIYNSSVALLTPLGVIVALALLGLFIIVQYAGVNVFGKSNAVMTWFKMAAIILTIIFVFAFIFHARNFFALSHGFLPYGPSSVFAAMVPAGVIFSYEGFRQGLDYAGETKNPKRSVPLGMISAMLAAMATYIMLQIVFIGAVNWKAAGVPVGDWSGLLSSTWSANPFFYAFHSTDETLLIGFSIFLIIVAVVSSASTLGVYVGSSARSLYGMAKMNYIPAFFGKIHPRFRTPWISLVVTFIIGAMFLLPFPSWYALVGINSSFTVFAYLAAGITNTSLRKTAPEMERPFKTPFLTVMAPLAFVIASMLVYFSGWSTVALLLLIVDGGLPIFLLSRYGRETFHINMRSASLFSAIYWVIFIFIGIIYALSLLPFEEYFALFSATILVTPYLLYRMSGRTASIHIRASIWIVVYSIILGIMSYYGSLGINAIPFPYDYIIMAIMSLTIYFIAINTGYHTDKLKEYQSTGGVTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3A0</accession>
    <name>A0A1V0N3A0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3311 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3A0"/>
    <dbReference type="KEGG" id="fai:FAD_0676"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11755">
        <property type="entry name" value="DUF3311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="6182" checksum="2DDA29FEC6BD241C" modified="2017-06-07" version="1">MVAGVTIYTRVKPELGGIPFFYWYQLVWIFIAAALTSTVYFIENSEKKRKVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3B6</accession>
    <name>A0A1V0N3B6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141904.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3B6"/>
    <dbReference type="GeneID" id="84217366"/>
    <dbReference type="KEGG" id="fai:FAD_0746"/>
    <dbReference type="OrthoDB" id="57128at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="61" mass="7250" checksum="1C5E63BFCA5B137E" modified="2017-06-07" version="1">MICEDLGYMILYNRSGRSVILTHDETVDLCLKAQESGLELPKYIMKNYMKDLKLIKFRYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3F0</accession>
    <name>A0A1V0N3F0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aconitate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3F0"/>
    <dbReference type="STRING" id="74969.FAD_0701"/>
    <dbReference type="KEGG" id="fai:FAD_0701"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006757">
        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009520">
        <property type="entry name" value="PRK12881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="7">
        <location>
            <begin position="57"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="8">
        <location>
            <begin position="651"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="830" mass="91547" checksum="DF6C3B443C0E4DAE" modified="2017-06-07" version="1">MNINERNLKYFPLAQLAGKYDIENLPYSLKILLENVLRNYDGVDIDERSIENIARMKSGSEMAFKPSRVVFQDYTGVPILVDLAAMREYYKENKLNADDVNPATKSDLVIDHSIIVDSFRGEEPIILNMKDEFERNVERYDFLKWSQQSFKNVRIVPPGHGIVHQINLEYLSSVAVIEKDEIFPESLIGADSHTTMIGGIGVLGWGVGGLEAEASMLNEPYFMNVPDVIGVNIKGSMPTGVTPTDVVLYITKTLRSKNVVGKFVEFYGNISELTAQDRATISNMAPEYGATIGYFPVDSETLKYLKGTNRSTESVEKYFKEQGLFYNGPKKYTDTVEIDLSKIKSAVAGPKNPDELINIEDLKGKIEDLLKEGNDGKLVKNGAVVLSAITSCTNTSDPFVLLGAGLIAKKAIEHNLTVANTIKISLAPGSKVVTEYLEKAGLMKYLNRLGFELVGYGCTTCIGNAGPLIPEVQDDMLKNNVKTFAVLSGNRNFEGRINPYIAGAFLASPMLVVAFAIAGKMNIDLINEPIGNDNGKPVYLKDLWPTNDEIKEYFHLAMDPEVYKKEYGDVFKGDNNWESMKSSKGLLFDFKEDSSYIKMPPWMYMEPVTDIKNGGILAVFGDKITTDHISPAGPIAKDSVAGKYLASMGITEMNTFGARRGNHEVMLRGGFSNTKIRNLMVSHTGGNTIYYPDGQEMSIYDAAMKYMKNKTPLVIFAGKQYGSGSSRDWAAKVTALLGVKAVVAESFERIHRSNLVDMGIVPVQVDKLPDLKGDEVVNIDGINNISIGKELNISINGKTLKGKALINTNAELNYVKTGNILKYIALSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3F1</accession>
    <name>A0A1V0N3F1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141794.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3F1"/>
    <dbReference type="STRING" id="74969.FAD_0689"/>
    <dbReference type="GeneID" id="31676190"/>
    <dbReference type="KEGG" id="fai:FAD_0689"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="113" mass="13177" checksum="93D3EA7B9A238CBC" modified="2017-06-07" version="1">MKEINKIRLKISFIPIAILIILIFLPLPFYFAGLFSYFKIMPLIILISAFFIFFVGAWWDFGANEYIKNLIVGHVELSENDLKYINRQQLIITLIYILIGLLYISIAFVLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3F3</accession>
    <name>A0A1V0N3F3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diphosphomevalonate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887886.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3F3"/>
    <dbReference type="STRING" id="74969.FAD_0787"/>
    <dbReference type="GeneID" id="16026006"/>
    <dbReference type="GeneID" id="31676289"/>
    <dbReference type="KEGG" id="fai:FAD_0787"/>
    <dbReference type="OrthoDB" id="275333at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048471">
        <property type="entry name" value="M3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048470">
        <property type="entry name" value="M3K_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040848">
        <property type="entry name" value="mev_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21433">
        <property type="entry name" value="M3K_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Mevalonate-3-kinase C-terminal" evidence="3">
        <location>
            <begin position="189"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="322" mass="36214" checksum="A87D59F81B2350D3" modified="2017-06-07" version="1">MEKYYVEVKAYPTIGILLLGGVSDNKKRLPRHTTAGIAYTGLDDDIYVKTDLYLSNQKSGIINGKEVSPDSPRSPFVVIDKYRHEILMRHPEYSEVSFVSENKNVISGSSDAGAAAIGECIQSIFEYNINIFNFENDLQQISESAGRSMFGGFTINHANGKESLTDEILGPEDFEDFVIVACKFSEDRKPSDTIHSNIINHEKYAERVKNSELRAKELEKMADSGDIKGIFEAGEKDTQEYHSMLREVGVSIITDEMQRLIEKVEELKAEFWNAYIVTGGTNVFVAVERKNMEKMKNAAMEFKCTPVYLKVAGKPDVISKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3I9</accession>
    <name>A0A1V0N3I9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141854.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3I9"/>
    <dbReference type="STRING" id="74969.FAD_0730"/>
    <dbReference type="GeneID" id="31676232"/>
    <dbReference type="KEGG" id="fai:FAD_0730"/>
    <dbReference type="OrthoDB" id="387683at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="763" mass="85220" checksum="E489C357971540BF" modified="2017-06-07" version="1">MRLKPFHVMVVIFILIFVTVFPVHASDGFNNAISPTYISGDKTTTQVSNVSNGGVNIVTSSSTPSYYIENESACNSTEYTFNVTGGINPDNNGGTENYIILKQENKTLFSISYGRKDTITTVSGSQDYNGILNLSGENIMYSVHIIMNNDIQNHALIWEGKEPAIPHVIALKNSYNPGNISFMFGGQFSNQTIGKLSVKHYTGLLLPGSQNTHKLTYKKSFILNPAPIKKNQTAFLDSSLNSIIYIHYKGVIERYNYYTNNYSTLGEIHNFQTENISSIQSGSHYIYYTWNNSFTSIYTINKTDLSVENYTYRNYNMTHLLFFNGNYVFYNLNGDMTFANGDKINIANVSILKVNVSRAINIIAKNKTGIESYTVTVDGQILNTGEQGITGHYNIKYFYINNGISSYFERGNLSRSINGYLYYHFSYIANNIGIDNGNIVQSSQGSVEALGVNAPDTMSSSNGTIIAANGQNIELYSNFTIASPYKITIRSVNEKVEFNSTILTLDINSGLPYHIVAVALNKTYNTNNSTLNLTFTGIHSGYYTIDFMAANIAGYTYNSSYVFQYNDSKYISNNTVTAINNVRIINDNGKFYVKINGNLIANATIAWYVNGKYSNTGKSLTTKLSTGIDKISVKITDGGKTYTDSRIVYYTGNLPYYAGFTGVFAILAIFLFETLYFNNKNVDELIIELNGSTLKKILKSGRRKRISGKLIRSRIKALNISGKISIERDMDNHKFIFADKSFIKSTREPVHGNRNSENNNGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3J2</accession>
    <name>A0A1V0N3J2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142018.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3J2"/>
    <dbReference type="STRING" id="74969.FAD_0822"/>
    <dbReference type="GeneID" id="31676323"/>
    <dbReference type="KEGG" id="fai:FAD_0822"/>
    <dbReference type="OrthoDB" id="27170at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="431" mass="48164" checksum="07274C92C8DD194E" modified="2017-06-07" version="1">MDSQHKSLPHRNWSRIDTWAFISFAMGMFIESYIFGMSSIATTWVKIPDSYKALLLSWSPLWLIIGIGIAGPVSDRIGRKQVFYITMSLYAIGAIGITFSYTFYLILIFLGILLFASGGEMNTIMALSQEIMPRQHRSSTMLLELNFIPLGGLVLAAVAFSSLYSSIYFQRLMVALTIIIVLVVLVASRRYLPESFLWLASKGKKEQAIADAKKYYGEAGYLERTDNTKDLSDSRDLNKTSHFWLKFFATLTTAFAGTTGFGLIAYELGPIIFPNLTDLILLVSSVAAFAMGLIGFFGEKISRKSMLLWGNLGALAFTIITYELIGTWSKYIILFWALVVILNAFVQLGYLAEDTLKSEVWATKSRGSLTALVRFLGIGLYIPTIYITYTYNIYQYMLFNILVWVIGSAGAVAWYILGKETGKGIPIELAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3L5</accession>
    <name>A0A1V0N3L5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="fai:FAD_0843"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
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    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="385"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="594" mass="67610" checksum="18269CD082F22333" modified="2017-06-07" version="1">MKIMDAEKAYSIRLAGEIVTEGDKTFFTEKYIKGTKYSSNIYSIVSKNIMQVTNGGAEKMPFYKDGVLYYIKYSEETETLMKLKSLSEPEIICTFYKIKKYLISEHGIFVIALEKTDDSKPFATTRIKYRFNGRGLLRSKYSLYAVDKAPHKIYSGDFDVEDIQCNNSRFIIQTTEESDDDGMSNLYEINKDGNKIKKITGKPGVIHGYSISDKGRIAVSMHENLNPWEVNRIAYPEEGKYLLVGKDSNDSILTDLFFTPSYKMKYNGDVLYAIAQEGSSSSIYAIEGEKVTKRTEVRGKLIDFDVAGVSGKEKISYIYSTPEHPSMVVNGDSYNINEEVAGIAPYVEGMDNGEYFFMLKDPAAPTLVFIHGGPQTAYGYLYYIEFQYFYQNGYNILYTNPPGSTGYGQPYEEECVGDWGNKDFEYIKKAMKSVMEKYKVVDNFAVTGGSYGGFMTNWIVTHSNIFKCGISERSISNMLSMVGTSDIGYWFNTLQLKITDPYSAEGIKKLMEYSPISYIKNVKTPVMLITGEEDYRCPIEQAEQFYVALKLNNVDAELVRYPGDNHEHARSGVPENMKDRLTRKLAWFDKYLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3M1</accession>
    <name>A0A1V0N3M1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142070.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3M1"/>
    <dbReference type="STRING" id="74969.FAD_0854"/>
    <dbReference type="GeneID" id="31676354"/>
    <dbReference type="KEGG" id="fai:FAD_0854"/>
    <dbReference type="OrthoDB" id="110773at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053172">
        <property type="entry name" value="Tn903_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053520">
        <property type="entry name" value="Transposase_Tn903"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033579">
        <property type="entry name" value="transpos_IS5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631:SF3">
        <property type="entry name" value="ISSOD12 TRANSPOSASE TNPA_ISSOD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="128"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="307" mass="36369" checksum="C519A7010A2EDC8F" modified="2017-06-07" version="1">MCRVKDNKINRSIKRYWIGSNRRWEKYNESLVDRIEYLTDLSFIKDYDTLLEEKNSGKIGHPYKVPDALIMYLARLRSIFNIPFRTLEGMLRSLAIIANIKSISYSEIFRRIRRIKPELNNINSKLDCIIDSTGYKITIRGDYLGHKWHRKRKGWIKLHVIISLKDVTVLSFTITDEHTHDSKAARKLLSKMKNNILRIFGDRGYDSKYIYNMFGYNAVIPPRKNASTKSRGSYARAKIVRFIKKNSMEQWKENNSYSKRWIVEIYFSGLKRVMTEVIKAKKIEYIIQELALKVVNYNIMRGMTHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3P6</accession>
    <name>A0A1V0N3P6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily multidrug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142010.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3P6"/>
    <dbReference type="STRING" id="74969.FAD_0815"/>
    <dbReference type="GeneID" id="31676317"/>
    <dbReference type="KEGG" id="fai:FAD_0815"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17504">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF192">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="14"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="490" mass="53007" checksum="F93247A57200D5E8" modified="2017-06-07" version="1">MEEQTYDKKYARFVLALFAMIIVAVMYVEGMLTPSLPSIAEGFHITVDQVSLVLSTYLLTGVALSPIVGKLADLYGKKKMMSIVMLIYAGAVSVTGFSPNFTFMVISRAVQGVGLTIMPLGMAMVREEFPRKMVPRAQALISGMFGVGFAVSLPLGSFISNYYGWRMTYHTAIPFIVALAILTLWKVKESRYRRPDVKVDYVGAIALGVPLALIVLAMSEGSSWGWHSLLFLGMAITGIVLLIPMFIYERHYYHHGGEAIFDMKLLSKRNVLIANISLTISGIGMYLSMQALSYRFETPEPYGFGFSILETGISMVAFAAGMIVFSIVTGKLISRTGIKPLAIAGSIVSAIGFFMLSASPGLVMTLADEAIIGSGMAIMNASIINLLVLSVEARDMGLATSMNSTFRYIGSSIGAPIAGTVLSLYTAVDVVHSATGNVIFSFPDATAFKYAFMIGAFTFVISAFVVLLSKEVLGRRMEVVKKSTVTPSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Q3</accession>
    <name>A0A1V0N3Q3_9ARCH</name>
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        <submittedName>
            <fullName evidence="4">DUF4147 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0831</name>
        <name evidence="4" type="ORF">HLB00_05155</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
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            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000175">
        <property type="protein sequence ID" value="NOL60222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142036.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Q3"/>
    <dbReference type="STRING" id="74969.FAD_0831"/>
    <dbReference type="GeneID" id="84217452"/>
    <dbReference type="KEGG" id="fai:FAD_0831"/>
    <dbReference type="OrthoDB" id="10741at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="entry name" value="Glycerate kinase, MOFRL-like N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="entry name" value="MOFRL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054996">
        <property type="entry name" value="Gly_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040791">
        <property type="entry name" value="gly_kin_Thpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227:SF0">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
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    </dbReference>
    <dbReference type="Pfam" id="PF05161">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82544">
        <property type="entry name" value="GckA/TtuD-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOFRL-associated" evidence="2">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="314"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="423" mass="46577" checksum="BE09263E197A140C" modified="2017-06-07" version="1">MQILNMDNIGTNSRRVYALEKIQNAINNLNPAAAMSRNFNVDTEKFDRVYVIGFGKASFNMYSGIRERVLKKLSYAGIIIPDDEVHNESYQELEILRGTHPYVSSLSVESSKKLLSHLDGLTEKDLVIVLISGGGSSLFELLETGIDVNDLKDISAEIMENDGDIYVLNRLRSSLSAVKNGKLAKYLYPASVAGYIISDVVYDNLNIIASGPLVNIPAPANLKELAKKYIKDARLRDIIEKVDISKTLDSKYFTNVKNTIVLKNRDFVDYIYSELEGEKINLGSNINGDVKVVSRDLTDILRNILEIKGEPFWFVCGGETTVTVTGNGSGGRNQELAVRVMENMGDNDFLFISMGTDGIDGKSIAAGGIVDNSTRIENLEEYLASSDTYTALSKAHGAIITGRTGNNVSDIMLGFYGRTNNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3X5</accession>
    <name>A0A1V0N3X5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3X5"/>
    <dbReference type="KEGG" id="fai:FAD_0894"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="63" mass="7594" checksum="89F5A5311F752EEB" modified="2017-06-07" version="1">MKSFKVKVNPEVLKWSIQTMNIPEDKIIESVHINKNTLNEWLYKYGRPIYVQLQKFSKLYMCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Y7</accession>
    <name>A0A1V0N3Y7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142293.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Y7"/>
    <dbReference type="STRING" id="74969.FAD_0989"/>
    <dbReference type="GeneID" id="31676488"/>
    <dbReference type="KEGG" id="fai:FAD_0989"/>
    <dbReference type="OrthoDB" id="135877at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="179" mass="20939" checksum="4BC44685EEB65BF1" modified="2017-06-07" version="1">MKELKKDLILKSAIKNFSINGYEASMDEIASDAKVSKGLLFFYYRSKENLIIDAAIKSVPLDVLNYIKAKEYSDIHSILYDLGTRFLDSYGNQDLRNLFLYTISNKNKYPEIKEKLKELCFTNFDEIFSKIKNISNLDFSLAKKRSFFGSLLCYLIWWNDNEQNIENYVEDLVNGFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N407</accession>
    <name>A0A1V0N407_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142332.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N407"/>
    <dbReference type="STRING" id="74969.FAD_1009"/>
    <dbReference type="GeneID" id="31676508"/>
    <dbReference type="KEGG" id="fai:FAD_1009"/>
    <dbReference type="OrthoDB" id="34235at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="161" mass="18790" checksum="F63C500FE6E9DD75" modified="2017-06-07" version="1">MDTVELLMLEHSGIRIIAYNNILQKGSAELMDFNKFLLNIHVNIEEAVVFPLLKENDSSTSKLINTLIADHKLIETLFNNLYKWKLSENPLFNVRLPLFYKTLTEHNSNEEILLFSRWKNINQEQQGIAMKNAHEIILSNDVENYAKETGISKEMMDYIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N412</accession>
    <name>A0A1V0N412_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas3</name>
        <name evidence="2" type="ORF">FAD_0941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142209.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N412"/>
    <dbReference type="STRING" id="74969.FAD_0941"/>
    <dbReference type="GeneID" id="31676445"/>
    <dbReference type="KEGG" id="fai:FAD_0941"/>
    <dbReference type="OrthoDB" id="36796at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="613" mass="70733" checksum="FD13AA829572DD4D" modified="2017-06-07" version="1">MSTIDIIFSINESYLSSSGTLHPFQERMKEFADYSNKKRVALLSAPTGSGKTFGFKNMVVDGFIMILLPNNLLSEDVYQDFNNVPIGVSLLNAKSVNQLLDKHKKEGFQDITKDKVIEELLSGSKICISNPEFFYYLILNKYKYYKLNDSLTDLLKDGLRLIIVDEVHVYSRDQINIILAILKLINNNIKIMFSSATIPNYFKNLVGLLFDEKNVLEISAEREYKKSPDNSILQGQLNVTIPAIYNITDFIKDRIGLLKNGYWFIIADSIRNIQSIYNVLAASSINKDEIGMISAYHDSGYLLYKEIFKNRKLRIIIGSNIIEQGVNPPRYFNNYVIEPGIDIKNFIQRVGRIGRNSTDSSNLYIIFKNPIGNVNDIGKINTIDDLFDFAAKKLPPKNLKYSARYIGVYASLISQYFSYKLQIVINDNINKDRDGAGFFSQYYRTRNTLEFIKKMQSDTKLYYNAIREVPEIKKIISWWEQYYTSITSFIPDTRKVEGFDIEEKVKFQYDYIWARKNKIIINENNGVILVKGFNDRPDYDFNVSVSGLPFYSQSVPFRDVSPYKARGYIIDKMRQCIGDTTSDIAEYQSFIESLKDIIMATADYERLSMEVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N415</accession>
    <name>A0A1V0N415_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142328.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N415"/>
    <dbReference type="STRING" id="74969.FAD_1007"/>
    <dbReference type="GeneID" id="31676506"/>
    <dbReference type="KEGG" id="fai:FAD_1007"/>
    <dbReference type="OrthoDB" id="46262at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="466" mass="53341" checksum="C8E206AE0D2D1C91" modified="2017-06-07" version="1">MSFKALVLFGSSTDLLESSFSSTLRLVESFDIDSVKILYSSFAEDQCIKLKELLQKVLKGESITIASEQINESGYETQFDRLIDSNTILSPTSGSKFYAFVSTKIAVEKNTTIIHTMFPFGPWKGMFYPFVPRFFQPVKTINGDIQPQEKVRNIFDNEEVVKKSISEFTHQKLGAYKISFRVGNMALKLNLNDPLNYYDGTPDVLTSLEISKNGVMSLNKTDPDSIIKFQFENKAKNFKLSYKKEGEFRQIEWSAFQDMKNLIKIAIDADLENLNKDNSGRNAISPADIIGLLGFEDIKVEGENLMERPIENLGDQVKGIVVDTNLVYSGILMYRGVKMMIPYCTYVEIANRRSELLKYDADNRIKYVYGTFLWESLTELMDRNQMLRTEAFFCDGVIPMIDPLLIKDCAIVTRDEGAYRHWLDIFPRNVMVMKATQNVSENRAKIVFALMLLSSMIRELKFSNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N458</accession>
    <name>A0A1V0N458_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_0995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142305.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N458"/>
    <dbReference type="GeneID" id="31676494"/>
    <dbReference type="KEGG" id="fai:FAD_0995"/>
    <dbReference type="OrthoDB" id="145578at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000007">
        <property type="entry name" value="Thioredoxin-dependent thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF4">
        <property type="entry name" value="AHPC_TSA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="163" mass="18045" checksum="C20569167CF25595" modified="2017-06-07" version="1">MALKNGDKAPDFKANDELGKIVSLADFKGKSSVVLYFYPKAETPGCTAEAKCFRDNWDAIKPLGAIVLGVSSDSEEKQKSFKDHHKLQFTLLSDKNKSIREAYDAKGFIIPARITYIIDKEGIIRGIHNSQMDPKSHIDFAIKTLKEISSTQAKNSPEAPGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N470</accession>
    <name>A0A1V0N470_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841317.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N470"/>
    <dbReference type="STRING" id="74969.FAD_1052"/>
    <dbReference type="GeneID" id="16024272"/>
    <dbReference type="GeneID" id="31676551"/>
    <dbReference type="KEGG" id="fai:FAD_1052"/>
    <dbReference type="OrthoDB" id="30774at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="169" mass="19313" checksum="1637A6E566F7B283" modified="2017-06-07" version="1">MEERSMDEIMEKISPLVTGNNVLDIGTGFGIVIKALINNKDLKITSIDPETWRFDELKNTFLTEIYENRLKLMNAYAENLPFRDNEFTTTISLFSAHHFKDIIKALDEINRVTSGTIIIADWGPESAGKTNPHSPEQLEIPMSKVKSHGIKNNYAVKDGSMWYMIYKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4A3</accession>
    <name>A0A1V0N4A3_9ARCH</name>
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        <submittedName>
            <fullName evidence="5">Radical SAM family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">FAD_1092</name>
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    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
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            <taxon>Thermoplasmata</taxon>
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        </lineage>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
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        <property type="entry name" value="rSAM"/>
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        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432:SF6">
        <property type="entry name" value="RADICAL SAM CORE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="SLR0285 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="29"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="275" mass="31453" checksum="A7EA826412A3CBFA" modified="2017-06-07" version="1">MPDNIKIIETNAKHALGKSGMAELDYAFNPYLGCFHGCRYCYAIDMSPAEAANNWGKVVFVRKNIIELLEHEARTYKKGIVGISTITDPYQSIEMKYRIVPEAIGILVKNGFYVTIQTKSPLILKDIKILEKYKKNIDVGITVTTINRKVSKILEPYAPDPFKRLNALKKLAETGIRTWLYLGPIANGVNDNIDDIDRIIEFCASTGTRIIYDSFQDFKGTVPYMAGTGYIKTGNEWWNSFRRAIEEACRRNNVICTSEEDEWKYEAQSRFRTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4A8</accession>
    <name>A0A1V0N4A8_9ARCH</name>
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        <recommendedName>
            <fullName evidence="1">Transcription factor S</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription elongation factor IIS/RNA polymerase subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FAD_1082</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
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        <property type="protein sequence ID" value="ARD84963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4A8"/>
    <dbReference type="STRING" id="74969.FAD_1082"/>
    <dbReference type="GeneID" id="16024313"/>
    <dbReference type="GeneID" id="31676580"/>
    <dbReference type="KEGG" id="fai:FAD_1082"/>
    <dbReference type="OrthoDB" id="72957at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10511">
        <property type="entry name" value="Zn-ribbon_TFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="3"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="101" mass="11303" checksum="32CB6BCE29022E37" modified="2017-06-07" version="1">MFCSKCGALMTPSRDKYICNSCGNEIPKAGTADQKIISKSSDKEIIMVAKEVNAEPLDSDAVCPVCHHTGAYYLLKQTRSADEPETKFYTCESCGHRWREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4A9</accession>
    <name>A0A1V0N4A9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TenA/THI-4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4A9"/>
    <dbReference type="STRING" id="74969.FAD_1056"/>
    <dbReference type="KEGG" id="fai:FAD_1056"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279:SF3">
        <property type="entry name" value="4-AMINOBENZOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PQQC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14518">
        <property type="entry name" value="Haem_oxygenas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01236">
        <property type="entry name" value="Haem_oxygenase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="225" mass="26453" checksum="54B89E3FB26FA89F" modified="2017-06-07" version="1">MYMQQSDFYGEIKRVVKSHSATDNDFINRFSRGDISDEEFKRFSIEFYHFTREWPEILAKLLVSTENENDAYELTGILVSELGSGDSGKRHELLYRRYLRSIGFKPEELVKREQLSTTKGWLDGMREYFSSDHAKALGAEFALENMAIPMWDKLLPGLKIMKERKYKDMDMLYFTFHRELESTHEDAMENVIGVHSNDQKEQFISSAKGMLDLEEKFWLGLADRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4E3</accession>
    <name>A0A1V0N4E3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1098</name>
        <name evidence="10" type="ORF">HLB00_00895</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000025">
        <property type="protein sequence ID" value="NOL59396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886202.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4E3"/>
    <dbReference type="STRING" id="74969.FAD_1098"/>
    <dbReference type="GeneID" id="16024327"/>
    <dbReference type="GeneID" id="31676596"/>
    <dbReference type="KEGG" id="fai:FAD_1098"/>
    <dbReference type="OrthoDB" id="372018at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000033">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="32"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="379" mass="42499" checksum="F24F67165212B994" modified="2017-06-07" version="1">MVSSRVNGINESATVSMSNKAAELKAAGKTIYSFGIGEPDFTTPEEIIDYAFKEAREGKTHYTPSAGIMELREKIAEKMKKKNNIDATASNVLVTPTKFSLNLALYSIIDPGEEVLLPAPYYVSYPDIIKLNQGKMITVPTDENYEFDFQEMKKYISPKTKAFMFNNPVNPTGKVYSEKSLRALADFILENDLYLISDEIYEDLIYKGRMFSPGSIEEMKDKTVTLSGFSKSYAMTGWRIGYMVAPLDIIKAANKVQQQTLTCAPSISQYGAMKALEDEESVAKMRQEFAKRRDLTVSLLKEIDGITLYEPEGAFYAFPGYSTEKADDKLSMELLEKYNVIVTPGSPFGAPGHFRISYATSQDVIREGIGRIEKYFNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4I6</accession>
    <name>A0A1V0N4I6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">ABC-2-type family transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1178</name>
        <name evidence="7" type="ORF">HLB00_05420</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000179">
        <property type="protein sequence ID" value="NOL60273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886280.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4I6"/>
    <dbReference type="STRING" id="74969.FAD_1178"/>
    <dbReference type="GeneID" id="16024406"/>
    <dbReference type="KEGG" id="fai:FAD_1178"/>
    <dbReference type="OrthoDB" id="87732at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43335">
        <property type="entry name" value="ABC TRANSPORTER, ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43335:SF4">
        <property type="entry name" value="ABC TRANSPORTER, ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="299" mass="33207" checksum="2EA125056891ABE7" modified="2017-06-07" version="1">MEIYLDSLTKNYRKIKALDSINLKIEGHGCTGLLGPNGAGKTTMLKLCTNIIKPSHGKVELNNVNVAIYPEKALEPVGALIEQPEFYSYLTGYEILEFTSKIKGIGKDEFKSEMKRLGELTGIDAYADRKTGTYSRGMKQRLALSVAMLGNPEIIILDEPTFGLDPKGMVDVRNIIKDIAKEHLVLLSTHLISEARELCDRTIIINGGKIEYDSAMSAERSLLKITATNSIDITGDKIKDYSRDGNVFIIEKNPSFSNYDIIGDLIKQGLKIEYVEKFDNLENIYVSVIGGKAKDNNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4I9</accession>
    <name>A0A1V0N4I9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="4">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">surE</name>
        <name evidence="6" type="ORF">FAD_1140</name>
        <name evidence="7" type="ORF">HLB00_04805</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000164">
        <property type="protein sequence ID" value="NOL60155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886244.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4I9"/>
    <dbReference type="STRING" id="74969.FAD_1140"/>
    <dbReference type="GeneID" id="16024369"/>
    <dbReference type="GeneID" id="31676638"/>
    <dbReference type="KEGG" id="fai:FAD_1140"/>
    <dbReference type="OrthoDB" id="26873at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="269" mass="29669" checksum="A533004679FB1676" modified="2017-06-07" version="1">MILVTNDDGFNAAGIKQLYKNASMVDDAVMVAPDSMRSASGMSITFTRPMRIQSLETYGINGYCVSGYPADTITVAQNIILKGKKIDLVASGINIGSNISLRSIYASGTISAAIAAALKGIKSIAFSMVTDQINGNEGPDFSKAGMYSRYIIEEFKKSGFPENADILNINFPAQITDETEIKVVPMAENVFHDYLEHNVDPNGKDYYWLGNTVEKTQDRNTDYYVLMEENNISVTPLSVYGHTVKNYEPTRKFFAGITKKIIENEDSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4J6</accession>
    <name>A0A1V0N4J6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142566.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4J6"/>
    <dbReference type="STRING" id="74969.FAD_1188"/>
    <dbReference type="GeneID" id="84217783"/>
    <dbReference type="KEGG" id="fai:FAD_1188"/>
    <dbReference type="OrthoDB" id="42691at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="268" mass="30908" checksum="3549EC7DB5113928" modified="2017-06-07" version="1">MGKDKPFKYKKYTANFEKQSILDYLGNNVIINENYESKAIELMQYITDKTDKHFSYNITGSAITALKQAHFSAKNGMASAAFENTRFFLERISLVKIISMMKTENNPYEIALEHMEWHRLIDKKFILYGLQQFTGRIWHYMGEKYVPTGNTIFLSGIPLCGNHSKAYTKYSRTVKEIEDEAGISIEEKCAKCGKEATRFTISLPKAGAILGMLGFYTGFDITKLGRFYGDYSRVLHPYGFYNYPGHFLINLWSIDFIRLGVELDKILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4M0</accession>
    <name>A0A1V0N4M0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1199</name>
        <name evidence="4" type="ORF">HLB00_09830</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000437">
        <property type="protein sequence ID" value="NOL61116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142583.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4M0"/>
    <dbReference type="GeneID" id="84217794"/>
    <dbReference type="KEGG" id="fai:FAD_1199"/>
    <dbReference type="OrthoDB" id="56669at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL61116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="92" mass="10477" checksum="03321FA3EF9FB1C9" modified="2017-06-07" version="1">MEEKEIDQAEINRENVEPKKKDERGVKAFVITMVGIVIVTAALTSGTYNGYDPNAYSVAITGFFVIVTIVMTAVWYRTKYDNYSYDPKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Q8</accession>
    <name>A0A1V0N4Q8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Acetolactate synthase</fullName>
            <ecNumber evidence="4 11">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_1250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Q8"/>
    <dbReference type="STRING" id="74969.FAD_1250"/>
    <dbReference type="KEGG" id="fai:FAD_1250"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
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        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005039">
        <property type="entry name" value="PRK06456.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="196"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="392"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="576" mass="62953" checksum="72BE758CEBC46616" modified="2017-06-07" version="1">MIGSKLLVDSLKREGTKSIFGIPGLYNMPMYDSLIEDIESGELRHILMRHEQAAAHAADGYARATGNVGVCTATAGPGVTNIVTGLITAYQDSSPVVAITGAVNRNAMGKLSFQESDTLGVSFPVTKYAVEVKTIEEIPVWVRNAFYIASTGRPGPVVVDIPRDIQMENIEKVEEPGKVNVHYKPFGTVINMDKVREMATNLLKAEKPVILVGNGVTWANATEEVLKLSEFLGCPVVSTLPGKSAVPADYPLYVGAMGYYGRAEASMVALESDLLLAIGARFSDRTFTSYEEMNDTKKIFMAINLDPTDFTKGIKPDVSMAGNAKVLVNELLKALSKMSRNGTRYAWNRRINELKEYYSQFSHPPDDGHMRPWKILKTLRESLPRDAILTTGVGQHQMWAETHWENLEPRSFFSSTGMGTMGFGLPCAIGAKVGKPEKVVVDYDGDGSFMMTGNNLATAVDENIPVIAVVNDNRTLGLVRQVQDMFQSKRIVGVDYGNSPDILKYAESFGADAFDANNYSDISEFIGKAIRDNVPAVIRVPVDKEELALPTLPPGGKLREVIVSDPRKGNKNTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4R2</accession>
    <name>A0A1V0N4R2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prephenate dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pheA</name>
        <name evidence="8" type="ORF">FAD_1206</name>
        <name evidence="9" type="ORF">HLB00_06245</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000215">
        <property type="protein sequence ID" value="NOL60432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142595.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4R2"/>
    <dbReference type="STRING" id="74969.FAD_1206"/>
    <dbReference type="GeneID" id="31676705"/>
    <dbReference type="KEGG" id="fai:FAD_1206"/>
    <dbReference type="OrthoDB" id="8755at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13631">
        <property type="entry name" value="PBP2_Ct-PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008865">
        <property type="entry name" value="PRK11898.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="188"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL60432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="270" mass="30349" checksum="890C89C37D0482D6" modified="2017-06-07" version="1">MKIGYFGEPGAYSHIAAIQMATGEYVSLESVRAVFMSLENGKISLAVVPVENSIEGAVNQTYDFLFRMNFYIIKEYYLRIKHCLIGHAGAKTDNITHVHSHPQALSQCSDFIYNHGMKPVSEYDTAGSVQIIKENYGLSHAAIASEIAANLNGMDILEKDIENNRHSYTRFFLIAKTPVKVSVPSKTSIVFSTKNKPGALYKILKILNDYGINMTKIESRPVQYTPFQYIFFIDIENNKNTDAAIADIQKSVEQFKILGTYETAYINDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4V2</accession>
    <name>A0A1V0N4V2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1273</name>
        <name evidence="3" type="ORF">HLB00_03230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000103">
        <property type="protein sequence ID" value="NOL59846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142735.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4V2"/>
    <dbReference type="STRING" id="74969.FAD_1273"/>
    <dbReference type="GeneID" id="84217868"/>
    <dbReference type="KEGG" id="fai:FAD_1273"/>
    <dbReference type="OrthoDB" id="205181at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF4">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY POTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="322" mass="37024" checksum="95751917DDD8B021" modified="2017-06-07" version="1">MNSIQKIEVPIEIRALKTANVYSINGDYNYIVDTGMSENGYRQIANTIDLSRIDMCIISHLHIDHIGGALYLEKNHNIPVYISKNDYDTIKNMVDNRQEYFSEYRNLMISNGVPEELFSNITEGNPVMKFMDYYASLNLNIIGNMAMKDTDIIDVPGHSPGSVAIYLKDIRAMVTGDHVLKNISPNISVYRNNVDYLGMYIESLKKIQNYDTEIAYPGHRDTFTNFAERIDQIIQHHEKRMYKISLELNTWKNAFELASSIAWSRGRKMDDMNNMEKNFAILETVAHLVHMERTGKIDSKYSGETILYHSIAGQFPPNQQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4V9</accession>
    <name>A0A1V0N4V9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142773.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4V9"/>
    <dbReference type="STRING" id="74969.FAD_1295"/>
    <dbReference type="GeneID" id="31676793"/>
    <dbReference type="KEGG" id="fai:FAD_1295"/>
    <dbReference type="OrthoDB" id="35688at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016878">
        <property type="term" value="F:acid-thiol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF1">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="457"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="545" mass="61448" checksum="A11F937E1C522128" modified="2017-06-07" version="1">MEKKKWFDIWPYYLPFTIDYPEMDIWEMLESPSRLYGNKNALVYYGNRIKYRELWQNVKNLSTYIKMMGFGKGDRIGIMMQNSPQFIISFFAISRSGATIVLMSPALDMETAEYIARDTNLKMVITTAELLKVPWDLHEKFNIPVICGLLKDYIKELDIPVPEFVLSDLDIRGVPWSEAVENRPDAGHVESGADAEALIAYTSGTTGIPKGCVHTNRSVISNAIGASIWRRLTSSAIELGAAPFFHVTGLSFSMLSPVYSGATIAILTRWNSEAAIEAIEKYRVTHFVSVAPMIVDLLNQKNLENRDFSSMRFIGGGGAAMPEILAEKMEDLFHIPFVEGYGMTETMGQTHINPPEHRKLQCIGIPQFGYDAKIISTETGTPVEEGTGEIVVRGPSLFTGYLNKPLDTMQAFVDIDGQKYLRTGDIGYMDNEGSFFVVDRLKRMINRAGFKVWPAQVDSLMLKHPDILEACVVGTPDPRNGEEVKAYVVLREPGRNKKISEMEIVEWAKKEIGGYKYPRIVEFIESLPKTATGKVDWRKLQEREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4X1</accession>
    <name>A0A1V0N4X1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142759.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4X1"/>
    <dbReference type="GeneID" id="31676784"/>
    <dbReference type="KEGG" id="fai:FAD_1286"/>
    <dbReference type="OrthoDB" id="386164at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="80" mass="9227" checksum="8BE822BAA4BE3EF5" modified="2017-06-07" version="1">MTVLSQADYERFTWKHRKLLFSYGVTVIIIKIATGYLNLKIGIGLNDTLTVLAIAGFLFLVELVLLYNYKKSIEKMNREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N523</accession>
    <name>A0A1V0N523_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA methylase N-4/N-6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142802.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N523"/>
    <dbReference type="STRING" id="74969.FAD_1325"/>
    <dbReference type="REBASE" id="195972">
        <property type="entry name" value="M.FacYORF1325P"/>
    </dbReference>
    <dbReference type="GeneID" id="31676817"/>
    <dbReference type="KEGG" id="fai:FAD_1325"/>
    <dbReference type="OrthoDB" id="57527at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA methylase N-4/N-6" evidence="3">
        <location>
            <begin position="402"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="811" mass="95849" checksum="F2E51740B85B2776" modified="2017-06-07" version="1">MVKNEVEFYQDLKNIFIGAKVEGNSGFVNLMRIKSAYFDKIFKLIQSDIDAKISEFPEFKEELFTRLHTFFKTYFSESGSIYFSYTPLKSKVYEKIYTNIQDVVLFWKTNMLYYVKTDNLWKSLSINYKIDNLEYKVVFDASQIEGKRANEKGEVVFELDKPDKIEDKVINFKSSYLVGGKKTKVSEILKGLNKTGIHITEEQLEELFHTFKKQTEVDYFINKDAKTFLREQFDLWLKNYIFDDDSVYSETRIKQLKILKNIAYNVIDFVSQFEDELVKTWNKPKFVLNSNYVITLDRIAEKDIEIINKILNNNGIDDQISEWKDLHLVDDNFNKNNIINMLDKSLNPDYKFLPVDTKYFKDIEFNIIKLFDDLDNELDGRLIHSENYQALNTILPKFKDKIQTIYIDPPFNKDKNADYLYNVKYKDATWITLLENRIRLAKDYLNEEGSIFVRCDYNGNMYVRLLMNDIFGGENFRNEMVVNRTQEFFKFSHGLNKFMVDTDTLFFYGKAGKSIFNEIKIKREIEKWWEPFLPGNPKDKDDCYRIVFKQKFPAPKGRKWGFSQDQIEELEQEDRIKIENGKIKYAPLGTTLKNNWTDIPGYSRHFDFPTENSEILLKRVIESTSNESDLVMDFFLGSGTTAAVAHKLKRKWIGIEMGEHFYDVVLPRMKKVLAYDKSGISKENDVKEKYNEKNAGGFFKYFNLEQYEQTLKNSVYLPSEPLYNLNDTSIYNQYVFFKDLKFLDKMEIDNKNNKIKFNFNGLYDNIDIAETLSLVKGKFIKSISKDEVVFNDAKIVFSDVDFTALKPLIWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N540</accession>
    <name>A0A1V0N540_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VapB-type antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142842.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N540"/>
    <dbReference type="GeneID" id="31676845"/>
    <dbReference type="KEGG" id="fai:FAD_1353"/>
    <dbReference type="OrthoDB" id="30861at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052975">
        <property type="entry name" value="Repressor-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34860">
        <property type="entry name" value="REPRESSOR-LIKE PROTEIN SSO7C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34860:SF6">
        <property type="entry name" value="REPRESSOR-LIKE PROTEIN SSO7C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="AbrB/MazE/MraZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="82" mass="9436" checksum="1AB133417214D8A9" modified="2017-06-07" version="1">MFEEEMTIGPKGQVVIPVALRKTLKITPGSKVIFKIDGDKIILEKLKMDSVNIFRNIAKKGKSVNEIKYNEYEDEIIKRNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N554</accession>
    <name>A0A1V0N554_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP sulfoquinovose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142861.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N554"/>
    <dbReference type="STRING" id="74969.FAD_1372"/>
    <dbReference type="GeneID" id="84217979"/>
    <dbReference type="KEGG" id="fai:FAD_1372"/>
    <dbReference type="OrthoDB" id="4907at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053578">
        <property type="entry name" value="UDP-sulfoquinovose_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041015">
        <property type="entry name" value="UDPsulfquin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="379" mass="43735" checksum="CBC1942BBD37E8AC" modified="2017-06-07" version="1">MKVLILGIDGYIGFPLALRLLDRGYEVYGADNFYTRRRVKNVGSKSAVKINSFATRNKKLNNAIKFYMGDVSNPKFVYDIIRDSGADAIVHLAEQRSAPYSMISLKTATETLDKNIESTMNIIYAVKDLNRDIHIVKLGSMGEYGTPNIDIPEGFLDVQFHGRSDKLPFPRMGQSWYHLSKIFDTYNLMLANRIWGLNVSDVMQGVVYGTRTPEITKYKLFTRFDIDQIYGTVLNRFISQAVIGYPLTVYGKGDQKRAFLSLEDSVECLNLILDHPAENEYKVYNQFDEYYPLNYLAETVKNRYESIYGKKVSINHVPNPRVEMEDHYYNPANQNLKDIGYRRQRSLEDEVPVMIKDVRNNINTVYSLKNVIKPSTNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N591</accession>
    <name>A0A1V0N591_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142908.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N591"/>
    <dbReference type="GeneID" id="31676937"/>
    <dbReference type="KEGG" id="fai:FAD_1444"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="198" mass="22951" checksum="6D38C90AFD5D6C81" modified="2017-06-07" version="1">MKTKATIGNYTVLLKSNLAQAIKVLYNTRKVIYYPANRDYPKLSEALDIFKLNINSMEDKGARVAIAFNGNFIYKKLDTDKKNSLIHFLDFLLLIPPPKFSIRKGKNTAIINEITVPKLSSILDSVLNFKFPRYWIDKQKEYESISIAIMRIINESDNNQSLPEPLWKIEQNLKEKDVESIKFYTAQIKEWISMGLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5B3</accession>
    <name>A0A1V0N5B3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YrhK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795589.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5B3"/>
    <dbReference type="STRING" id="74969.FAD_1428"/>
    <dbReference type="GeneID" id="60420015"/>
    <dbReference type="KEGG" id="fai:FAD_1428"/>
    <dbReference type="OrthoDB" id="57486at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025424">
        <property type="entry name" value="YrhK_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14145">
        <property type="entry name" value="YrhK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrhK" evidence="1">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="317" mass="37262" checksum="C6BA9A68C3125BE7" modified="2017-06-07" version="1">MDNNSLGDPLYFLYAIQRSPYGFNLKWKHVKPLISYMFGKEVFENLKNDQVINTYNDENILEIINIPDIKYNIPDAEKEILFHKFIDFVSGNKLISGIMKIMYLDRKIAQFIIDILNQNPDKTMDDLVEASAFPIVNLPDFYYSKAFADYCKPYIENFNLDMKDILKYLGREWFVKLVIILREGTFNNNSFSKSMENNCHEFISGVREIIENDYLAEIIVNLDLFLSDRSVNRAIMNYASRSVKEKFIKRFYDWLSIANDIMVGLEFVIGSIFFLPSEKQYSTLGVYLFIIGSTQLLIRPMINIARRIHIFFLHKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5C9</accession>
    <name>A0A1V0N5C9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="5 14">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FAD_1482</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the aTrm56 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="5 14"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142925.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5C9"/>
    <dbReference type="STRING" id="74969.FAD_1482"/>
    <dbReference type="GeneID" id="31676975"/>
    <dbReference type="KEGG" id="fai:FAD_1482"/>
    <dbReference type="OrthoDB" id="14397at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106059">
        <property type="term" value="F:tRNA (cytidine(56)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18083">
        <property type="entry name" value="aTrm56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00077">
        <property type="entry name" value="tRNA_methyltr_aTrm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003048">
        <property type="entry name" value="PRK03958.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009343">
        <property type="entry name" value="PRK12703.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="TRNA (CYTIDINE(56)-2'-O)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197:SF1">
        <property type="entry name" value="TRNA (CYTIDINE(56)-2'-O)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="HD" evidence="15">
        <location>
            <begin position="190"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="107"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD85340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="349" mass="38919" checksum="CF702EFD77365925" modified="2017-06-07" version="1">MITVIRIGHRPFRDKRITTHVALVSRAFGADRILVDEKDETLESTVNRVTENFGGNFSIKTGINWKKEFKDFNGVKVNLSMYGINVDDRIGAIRESVKGKDVIILVGAEKVPIDAYNIADYNIAIANQPHSEVSALAIFLDRFYEGKELEKKYEGKMNVIPMDNGKMVKFIPDEQQCMKLLYGEKADERIIEHVTTVYKLAMAIGKYAGANMELIRAGALLHDIGRTKTNGIGHAVAGADILREKNIDEAIVRIVEKHTGAGILPDEAKKLGLPDRNYIQETLEEKIVAQADNLVSGKKIVTLSDTVNSYHLKGLDEPAERIKKLHMELSSICGKDLDIIGKEVIMEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5D5</accession>
    <name>A0A1V0N5D5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine biosynthesis bifunctional protein HisIE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <shortName evidence="13">PRA-CH</shortName>
                <ecNumber evidence="13">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Phosphoribosyl-ATP pyrophosphatase</fullName>
                <shortName evidence="13">PRA-PH</shortName>
                <ecNumber evidence="13">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">hisI</name>
        <name evidence="13" type="synonym">hisIE</name>
        <name evidence="15" type="ORF">FAD_1448</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the C-terminal section; belongs to the PRA-PH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">In the N-terminal section; belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="13"/>
    <dbReference type="EC" id="3.6.1.31" evidence="13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142911.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5D5"/>
    <dbReference type="STRING" id="74969.FAD_1448"/>
    <dbReference type="GeneID" id="31676941"/>
    <dbReference type="KEGG" id="fai:FAD_1448"/>
    <dbReference type="OrthoDB" id="5853at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000001">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01019">
        <property type="entry name" value="HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023019">
        <property type="entry name" value="His_synth_HisIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000768">
        <property type="entry name" value="PRK00051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002747">
        <property type="entry name" value="PRK02759.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42945">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42945:SF1">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-AMP cyclohydrolase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-ATP pyrophosphohydrolase" evidence="13">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="203" mass="23202" checksum="C6561D8871F2AC00" modified="2017-06-07" version="1">MSDYDLKFEGLMPVVVQDSETKEVLTLAYMDEEAYRKSMETGLMHYYSRSKQRVRMKGEASGNIQEIKDVMIDCDNDSLLFMVKQKGAACHLGTKSCFREIGTPVVVGNINYSLEVLLELESLIAKTKNTPRKNSYTTELFESGEENIKKKVGEEAVESILAQGKDRIVYETADLLYHLLVFLSYENIKLSDIMDELSKRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5F2</accession>
    <name>A0A1V0N5F2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABM superfamily monooxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1467</name>
        <name evidence="3" type="ORF">HLB00_04505</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000152">
        <property type="protein sequence ID" value="NOL60096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886572.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5F2"/>
    <dbReference type="STRING" id="74969.FAD_1467"/>
    <dbReference type="GeneID" id="16024697"/>
    <dbReference type="KEGG" id="fai:FAD_1467"/>
    <dbReference type="OrthoDB" id="8690at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050404">
        <property type="entry name" value="Heme-degrading_MO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34474">
        <property type="entry name" value="SIGNAL TRANSDUCTION PROTEIN TRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34474:SF2">
        <property type="entry name" value="SIGNAL TRANSDUCTION PROTEIN TRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="101" mass="11803" checksum="4ACE2DE0925F0E79" modified="2017-06-07" version="1">MIHVGLYYKVKEGHNDDFVKTFNNVLELLKSKPETGFVDGKLYQEVDSPREYMIYTEWKSREAFKDFVEMKAFKDTTDYGKSILEGAPRNKIFGESNGQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5H6</accession>
    <name>A0A1V0N5H6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142932.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5H6"/>
    <dbReference type="STRING" id="74969.FAD_1502"/>
    <dbReference type="GeneID" id="31676993"/>
    <dbReference type="KEGG" id="fai:FAD_1502"/>
    <dbReference type="OrthoDB" id="380821at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="130" mass="14530" checksum="759F2074D2A4017A" modified="2017-06-07" version="1">MAAIIESTLKTEKLVKPINPDASNLYIPARSLKFSSKLGIENEIDMEGRILKVTGKEKYLNTDDLADLEGTPVRLYLNPGGCGPNDGIFFSRNAYKTLDAHSIIPEKYTIRLEIFSIGENEIKDDIEIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5H7</accession>
    <name>A0A1V0N5H7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF47 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142939.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5H7"/>
    <dbReference type="STRING" id="74969.FAD_1509"/>
    <dbReference type="GeneID" id="84218102"/>
    <dbReference type="KEGG" id="fai:FAD_1509"/>
    <dbReference type="OrthoDB" id="56776at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="entry name" value="Phosphate transport system protein phou homolog 2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="UPF0111 PROTEIN HI_1603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536:SF3">
        <property type="entry name" value="UPF0111 PROTEIN HI_1603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26111" checksum="C8896010CA4B883F" modified="2017-06-07" version="1">MVNYNFLKRILVVGEKNLLSRLSQYPLMGIESSSNLIFMLKNAPSDIEKYNEIVRQIEKKGDEMDINFRHEVTSGAISSSLMGNLLDLIEKCDDILDKCYFTSREINRFNINYSMTPDEVVIKEYAYGSFIKILEANKESLEFVHSILNENDLSNMRGDRKSIEAIEEQVDEIKDNIIDYTYKNSTKMSYIVFEHLNTLAHKLDDLLDDCEDISDLIFTIMLAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5I3</accession>
    <name>A0A1V0N5I3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA repair helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FAD_1503</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142933.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5I3"/>
    <dbReference type="STRING" id="74969.FAD_1503"/>
    <dbReference type="GeneID" id="31676994"/>
    <dbReference type="KEGG" id="fai:FAD_1503"/>
    <dbReference type="OrthoDB" id="27512at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD85355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="621" mass="72041" checksum="27F51CC565B195A7" modified="2017-06-07" version="1">MEKFTPREWQDALISTVSKNLEEKNKIAIEAPTGSGKTSFILYLAFITGKKLIYLTRTHNEFTRLYEDNQKYFNIPALYLYGKSKLCPLKERWYDSEDDGQKNVCKGCPLKDKTIKLDLKNIRSPESFLEDIEADSTELIRQDVESKALGRDTKGNLVTIKKENVKSYCPYYSVRSNMADAQIIAMTYNYLLNPSIRFNVFHGTEGEEMIDLNECYIVFDEAHNLDSVIENFGRTLQIKTVEKAIDMLVKDFPIENYNSYDRIEANLILENLLSNMSSTRGTDSLKLFKFSNDFASRIANLESLRAFSDEFEEKNENRPLNKRSRNYLENVYNFLYDYQRMENGSVYSTINNPEKKDLKLKLMYYDTSGYLSFLRDNSVIFMSGTMPSVDHISKVWNMENVLYLKVDSIFKNAGGLKQYHIVNGYTTLGRYRENLDDWAEMLRKYMQFAIDVYSKSDKSVLVAVPSYRILFGDTYTKTPGIGNYLPESMRANCVFENKKISYSYIEKKAKERKIIIFSVHGGKLLEGIQLVNRGKSLISDVIIAGLPLIPLDDYRKDKIKYLEKVLKKNAYNLLYYEFALIKVKQAAGRSTRSPEDTSSIWLCDDRFDEPFWQSNLLPNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5K5</accession>
    <name>A0A1V0N5K5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">APC family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1575</name>
        <name evidence="8" type="ORF">HLB00_09550</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000423">
        <property type="protein sequence ID" value="NOL61061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142962.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5K5"/>
    <dbReference type="STRING" id="74969.FAD_1575"/>
    <dbReference type="GeneID" id="31677066"/>
    <dbReference type="KEGG" id="fai:FAD_1575"/>
    <dbReference type="OrthoDB" id="44166at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL61061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="504" mass="55122" checksum="18C3A08145705CF8" modified="2017-06-07" version="1">MSESNKTRSTDSTSKELSKKSISLLGLVIISMAGTLAIIGPMEVSSFVGSAGPAAMWPVILGFLLFIIVSLPIFEYTKFTNFAGGYYGLAELGFGKAVGKYTALSNYTFYIFWQVTNFFAMSAIIVDSVYLLYNYMIPIWGWLLIGVAVLILTNVMSSLHPKILSKVLIYITIATTILVLGFVFYVILKSPYNSAYYVNPLNSYSGFTGIAKGTAIYGFFLFVGYGSTLFYSEEAKNGRKDVWKAIYIGLGISALVIALSAYSVVATVPSSKLGAISSSTLPELVSWIHYIPAPALLILSFIVVVISMLSFGAGAGSQSRLMWSMARDQFIDSIKLRKLSKNKTPTNAIILQFIVVIVFAFSAGGALVAIYGYSISTITIAWFAAGAGGTVVWYFHHFIPEFGLFPYINKHKELKYSFARKWIIGIVVPLGGTALFVYTFYLGIVSDLLEPYFSFMLIAVAALLGIVIYVTYKAKTNKLGESTVSYMAAEAEQVELSNDDETDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5M0</accession>
    <name>A0A1V0N5M0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1552</name>
        <name evidence="2" type="ORF">HLB00_00945</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000027">
        <property type="protein sequence ID" value="NOL59406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074037.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5M0"/>
    <dbReference type="GeneID" id="16024821"/>
    <dbReference type="GeneID" id="31677043"/>
    <dbReference type="KEGG" id="fai:FAD_1552"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="377" mass="42430" checksum="8669C8013629E59A" modified="2017-06-07" version="1">MKKKIIIGVLMVAIFLMSGFNIVTGIENTGANTAVTSLSSNSSVYNKNGNNLKNIENQKINIYKVGNYSILSCNNMLSRNNILNVDIDNHYYEIKWIVSMVAGNETFQLHFHNYNIIYTDNSIIVHGWDRYAGIYNVLSVNNKSLNSNIVIKSNVAAVYNIKFVEGNNIKNYRTVKLSDNYSASLINGIKTSWANEMGIFHNGILRINNNSYMLSLNFNNIKLNKGQAYSIDPAIKPMRLPVEPCTTTLTFKLYDNTLTKIDIYNIKNEIIVDGTDISYDAYYCLIDTANWHKVSCSTSHGNYYSTINACFMGYFGTFWLTAVSTEISLSSGVFHGTIKIAILELVDNVWIPYKSETVVNSQISAATDNSYKEYIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5M7</accession>
    <name>A0A1V0N5M7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1587</name>
        <name evidence="6" type="ORF">HLB00_01515</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000041">
        <property type="protein sequence ID" value="NOL59515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142971.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5M7"/>
    <dbReference type="STRING" id="74969.FAD_1587"/>
    <dbReference type="GeneID" id="84218180"/>
    <dbReference type="KEGG" id="fai:FAD_1587"/>
    <dbReference type="OrthoDB" id="46222at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43630">
        <property type="entry name" value="POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43630:SF1">
        <property type="entry name" value="POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="4">
        <location>
            <begin position="135"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="256" mass="29720" checksum="C28F6F9ADBE62FD3" modified="2017-06-07" version="1">MEGISAIITVLNEEKNIRDLMVSLISQEQPFEVIVVDSMSTDKTPKILKEYAEKYDFVKYYRKKTTRGGGRNYGASKSNYDYLAFIDGDAIAGEAWIKNLRALTQNYNLVAGKSINTGNMRYSMERFRLYYEGFEVTRPSSNLMYSKSLFQSIGGFDENFVTAEDIDMNIRAVKSGAKYAVCDTCIVYTKTRETFRDFKKQAYWNGYGRRQLKEKYGKTLELSHRLNMKDLFSPTYVIRNFYGLRGYMHCMLKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5N0</accession>
    <name>A0A1V0N5N0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl13</name>
        <name evidence="5" type="ORF">FAD_1597</name>
        <name evidence="6" type="ORF">HLB00_01560</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000041">
        <property type="protein sequence ID" value="NOL59523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886730.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5N0"/>
    <dbReference type="STRING" id="74969.FAD_1597"/>
    <dbReference type="GeneID" id="16024863"/>
    <dbReference type="KEGG" id="fai:FAD_1597"/>
    <dbReference type="OrthoDB" id="7668at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005004">
        <property type="entry name" value="PRK06394.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="137" mass="15392" checksum="5BEA296F12595A7D" modified="2017-06-07" version="1">MIYIDGDNHIYGRLSTYVAKQLLSGEEVVIVNASKIAITGSRKFILDKFNHRRNIGSVRKGPYYPRTPDQIMRRSVSEMLPIKKTKGLEALKRCKVYSGIPKSLTDVEFVKIDKAMNTNATGFITLGDISKILGENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5N5</accession>
    <name>A0A1V0N5N5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886687.1">
        <property type="nucleotide sequence ID" value="NZ_DAIEUD010000005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5N5"/>
    <dbReference type="GeneID" id="16024816"/>
    <dbReference type="KEGG" id="fai:FAD_1547"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="75" mass="8877" checksum="2E283F08CE001FE7" modified="2017-06-07" version="1">MIKYHFNNKYQEIFVMLMLSFTGLNALTIFNTIPLSIQKTFIFDVIDLTLIFLAISFLIAGSIEQYLKNRRRINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5N7</accession>
    <name>A0A1V0N5N7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase BadF/BadG/BcrA/BcrD type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142961.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5N7"/>
    <dbReference type="STRING" id="74969.FAD_1574"/>
    <dbReference type="GeneID" id="31677065"/>
    <dbReference type="KEGG" id="fai:FAD_1574"/>
    <dbReference type="OrthoDB" id="39947at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052519">
        <property type="entry name" value="Euk-type_GlcNAc_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190:SF3">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="326" mass="36012" checksum="4D5F7BFE746E7947" modified="2017-06-07" version="1">MKIMSVDGGATKTVAALYDSNEDKITSIGISGPSNYFSVPHEESQNNIVSAISSAYHNWKQDDIKFIVGIAGFGDSKKANEIGKSIMDRIFSNKPYILENDGICAYRMAHLFDDGGIFAPGTGSIAIYQHNNEINRLGGWGWFAGDEGSASWIGKRSITMAEEQYDGIIEGSSLIELLESYFHNDFIELINKFETAHPKREIAMLAPHISKLALEGDKASNVVINEAAGYDAKILHVLDNKLVNKSMALIGGTTGSDILIKNVKKYYNSKLKFYHGYDVCTGGLLIAADRNNIRIDKNFRDKLVSNVEELIKMVNPEDLKKYLGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Q2</accession>
    <name>A0A1V0N5Q2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">alaS</name>
        <name evidence="14" type="ORF">FAD_1634</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142985.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Q2"/>
    <dbReference type="STRING" id="74969.FAD_1634"/>
    <dbReference type="GeneID" id="31677123"/>
    <dbReference type="KEGG" id="fai:FAD_1634"/>
    <dbReference type="OrthoDB" id="7506at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="13">
        <location>
            <begin position="58"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD85478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="891" mass="102661" checksum="B772DD49BE1F692D" modified="2017-06-07" version="1">MVQDEFDLDFFRDNNFLRKQCIVCSSFFWTQNPGKKTCGDPACEGYSFIGNSPVDRKYSLDEMRQEFLSFFKEDKLPHTIIEKYPVVPRWRDDVLLVNASIYDFQPQVTSGLVPPPGNPLAMSQPSIRMLDLDLVGKTGRHLTSFEMLCHDAFNYENKYIYWKNETIEYSYRFLTEKLHVDGTEITYKEKPWFGGGNAGNAVEVFVRGLEVATLVFMDMKEDPDGEIDIEGTKYSMMPLKIVDTGYGLERLVWLSTGTPTVYESILGKTIEYIRKNSSAGDMDPEIMQKLSELSAEIDPYSESKLLKQVAPWLKEKHIYIDDEFLSRLKSVRSLYSLADHTKTLLLMFADYVIPSNVKVGYLARTLIRRSLKFMDDISFSQDFMDLMDFQHEIFSRIVSNYDRDFIKNIIDIEKEKYAEINKSAEGKVRKYIHSGKLELKDAITLYDSEGMNEDLISESFKKITGKDLELPDNFQEIVISRHETRHTKKKEMPQFPPVHTRPLYYDNTKISEFTGIVLYSGEKCIIPNQTAFYPEGGGQPCDLGYFIANGKKVNVVDVQKYNDSIVHFLDNNIPANSRVKGYIDYTRRKQLMIHHSATHLLLGIMRKYFGEHVWQSGVKKDIKESRIDITHYRKITLEDIRHIEDMCMEAIEQDRKITVSNVSWNPAIEKYGFRLFEGGVPVSSKIRVVTIDGIDSEGCGGTHLDSTAPIGFIKIMKVETLQEGIQRITFSAGPAAMRYVQLVYDTVQMEQEYLKVDTEDVYRQSLEIFHENLENRKLIDKYRKEKIEGILNSREPVHENIYVYATNLDRYEFNLLIQGIFRKNIKAIIINSETELTAIGIDAGVDTLISGLSTRNIGIKEKSRNRKLYTAICNPGINEKLIKEILVSINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5T0</accession>
    <name>A0A1V0N5T0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S2P/M50-2 group multipass membrane metalloprotease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Site-2 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1633</name>
        <name evidence="10" type="ORF">HLB00_02425</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000074">
        <property type="protein sequence ID" value="NOL59689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142984.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5T0"/>
    <dbReference type="STRING" id="74969.FAD_1633"/>
    <dbReference type="GeneID" id="31677122"/>
    <dbReference type="KEGG" id="fai:FAD_1633"/>
    <dbReference type="OrthoDB" id="57579at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06160">
        <property type="entry name" value="S2P-M50_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412:SF0">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="593" mass="65422" checksum="BD3F0B7B8E78D43D" modified="2017-06-07" version="1">MIESSTIDGIVKKYYDVSEVENTRYSMVFHIQGRGDEKTFGYLLDELAPVGATAFTNDFPDSQIIVINNGNVSRERRGLKTLMLFLSMAALIYTGSVYYSSYYSSDLIYRNIIYGTLFYAIPVISILLFREAGKYIALRKNHIKYNFPIFVPSPGLGTLGTINSNKNQFRDSKSMIEAGTFSLFFGFLASILLIIAGAAIMPYVNYSSAIHSPISVLNFPLVFPVALDHLFPAYIIPDPLELAGYVGIITTALNSMPVGFMDGGLVFSGILGKQFKYASYAGIAILLAASILYPYILILAVLSILLGIKGALPMNNFFKPRASVKWLALVIVVIVIILGFAPLPLHNTDSNNVAIPDSCYIMQQNNTGNVSVNITVQNHGVNISPLFSVTPGNFTVKGFTQNKADTIYTLELITYNHNYSGRKNFTITVDTGMSSVNKTVSVYFLKPDSNMHINKTMGPENLTVKEYKPFNITIFNNSNSTLNAQIIPIFNSTGLYMSLQNNLNAEINLNPHIPLGILQIYGGQNQTLTLVSYDPGNLKLIIMGQGGQAAIVNIHILPEPRPRTVSPPGIFPTINYTGYYEMQLGTIHPFYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5U5</accession>
    <name>A0A1V0N5U5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Transcription elongation factor Spt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nusG</name>
        <name evidence="4" type="synonym">spt5</name>
        <name evidence="8" type="ORF">FAD_1612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Spt5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5U5"/>
    <dbReference type="STRING" id="74969.FAD_1612"/>
    <dbReference type="KEGG" id="fai:FAD_1612"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06091">
        <property type="entry name" value="KOW_NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09887">
        <property type="entry name" value="NGN_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00950">
        <property type="entry name" value="Spt5_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="6">
        <location>
            <begin position="140"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR00405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="297" mass="33488" checksum="8F9971F1A60BF340" modified="2017-06-07" version="1">MEYDWLTADIPDVINAGCDKRIKQLEEKDDREKIIPLAITVKNIQGAKRKFNINIRTSLELQDPSIDWKLKLKDEYTLSSKKIEEITYDFDLDGNKSRDLGLEIDTPIGGYEGDRLDIDLSIKSEDGINSYNKKFSVNLVPVIKIAKCTIGKELDIAIDLSNHAERDREERMAMNKNARNEVMAVMSPYEIKGYFFIETMHADRVDVLSKSIRGFKGFVSGDIDISEIEKYLTPKPAVTGLEMGSLVEIVEGPFKGERAKITAIDAAKEEVTVQLIESMVPIPVTVKAEAIRNLDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5W0</accession>
    <name>A0A1V0N5W0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ribosome biogenesis protein Nop10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">nop10</name>
        <name evidence="8" type="ORF">FAD_1657</name>
        <name evidence="9" type="ORF">HLB00_04450</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000151">
        <property type="protein sequence ID" value="NOL60085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886794.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5W0"/>
    <dbReference type="STRING" id="74969.FAD_1657"/>
    <dbReference type="GeneID" id="16024926"/>
    <dbReference type="KEGG" id="fai:FAD_1657"/>
    <dbReference type="OrthoDB" id="7259at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00803">
        <property type="entry name" value="Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023532">
        <property type="entry name" value="Nop10_arc-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009623">
        <property type="entry name" value="PRK13130.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL60085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="59" mass="6770" checksum="DF36FB5AAB84FC17" modified="2017-06-07" version="1">MRTLIRICPSCKLYTMNDICSNCGTATVMAIPMKYSPADKFQKYRIKLLEDEHNGKNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Z1</accession>
    <name>A0A1V0N5Z1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143033.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Z1"/>
    <dbReference type="GeneID" id="31677188"/>
    <dbReference type="KEGG" id="fai:FAD_1696"/>
    <dbReference type="OrthoDB" id="57739at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="171" mass="19530" checksum="2749231586830838" modified="2017-06-07" version="1">MVKIIGSIDNAAHMNDTYYLIFTDNEMYQFLTMSAKERLSDMWHTTMGNPERMAPVVGNYSNYKVTQEEAENIVMENARRGKEIEDNLETKLSEVPPQYTVIPYSTVDKAELSGGTVVSLPEILLHANRKKLKFHLVRCNFHGRGKLTDEIFSQYKETLTTAFGSKLKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N629</accession>
    <name>A0A1V0N629_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lrp/AsnC ligand binding domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1769</name>
        <name evidence="3" type="ORF">HLB00_01195</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000034">
        <property type="protein sequence ID" value="NOL59453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143079.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N629"/>
    <dbReference type="STRING" id="74969.FAD_1769"/>
    <dbReference type="GeneID" id="84218393"/>
    <dbReference type="KEGG" id="fai:FAD_1769"/>
    <dbReference type="OrthoDB" id="8136at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="77" mass="8711" checksum="6A5B129BB9418129" modified="2017-06-07" version="1">MSVAFVLIRVIPGKEHEVYDRVSTLKYVTEIHPLLGEFDILVRIDTEDMSEIGKLIIQDIRSISGVVDTKTLAEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N632</accession>
    <name>A0A1V0N632_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1732</name>
        <name evidence="10" type="ORF">HLB00_00215</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000007">
        <property type="protein sequence ID" value="NOL59262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143064.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N632"/>
    <dbReference type="STRING" id="74969.FAD_1732"/>
    <dbReference type="GeneID" id="84218353"/>
    <dbReference type="KEGG" id="fai:FAD_1732"/>
    <dbReference type="OrthoDB" id="56630at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="Polyprenyltransferase_UbiA-li"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009609">
        <property type="entry name" value="PRK13106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="298" mass="33134" checksum="EF606838BA3BBA2E" modified="2017-06-07" version="1">MWDPGGAKDKKGKLYIILRFLRMEQTFFSLPMAYLGAFLAVRKIPAIRILILIFFALFFVRIAGMTNDNLADRFIDAKNPRTMTRPLVTGVITVKNAYALIAIGLAGYFISTYFINILAFSISPLGALVIMTYPYMKRHTAFANYQIASIQGLSVMAGAIAAVGLHSPVYIIYHMPWFFVFATIFWALGFDLYNHIPDIKYDRENKLHSFATLLGDRALQFAGLNQILSVSLAFAGDIVYRLGILSYATTTLHGAIMLSAFILAYRGNFGKAFYYNIYASVVLALGIIIDVALGLPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N672</accession>
    <name>A0A1V0N672_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1765</name>
        <name evidence="4" type="ORF">HLB00_04125</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000138">
        <property type="protein sequence ID" value="NOL60020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143076.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N672"/>
    <dbReference type="STRING" id="74969.FAD_1765"/>
    <dbReference type="GeneID" id="84218389"/>
    <dbReference type="KEGG" id="fai:FAD_1765"/>
    <dbReference type="OrthoDB" id="384961at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="17"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="170" mass="19114" checksum="7D47D2EB1A323742" modified="2017-06-07" version="1">MEKPGKSIVRLRNSIIPAIFIGITITFTILFLSLLHIYIIPIAKFIVFSSFASSCFLLFMEPEQKSSRLSKFVVSYIISGAIGIAGAFIEPYIGIYYTLAIVETIIAMLLVEARAMHPPAMGIAVVFILEKANVFALLFLFSGMVLIIIFDKFLNKFVYLFDDEVKKIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6A1</accession>
    <name>A0A1V0N6A1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uridylate kinase</fullName>
            <ecNumber evidence="4">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Uridine monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_1802</name>
        <name evidence="16" type="ORF">HLB00_07605</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Berkeley</strain>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000280">
        <property type="protein sequence ID" value="NOL60693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886950.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6A1"/>
    <dbReference type="STRING" id="74969.FAD_1802"/>
    <dbReference type="GeneID" id="16025081"/>
    <dbReference type="KEGG" id="fai:FAD_1802"/>
    <dbReference type="OrthoDB" id="372251at2157"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006225">
        <property type="term" value="P:UDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04253">
        <property type="entry name" value="AAK_UMPK-PyrH-Pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011818">
        <property type="entry name" value="Uridylate_kinase_arch/spir"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02076">
        <property type="entry name" value="pyrH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42833">
        <property type="entry name" value="URIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42833:SF4">
        <property type="entry name" value="URIDYLATE KINASE PUMPKIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD85641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="NOL60693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="225" mass="24535" checksum="164373D4259A0B6A" modified="2017-06-07" version="1">MNSVVISLGGSIISKERLNLKLMEEFSETMKSISTYDKFGIVVGGGKLARTYISDLKKYNVNDNILDEIGINATRINALAMTTFFDDVNSKIPTNINDAAEMLHNYRYVVMGGTEPGHTTDTVSTLLAERIGSKVLINATSVDGVYSSDPKIDNDAKKFSKLSYNEAISLSIKNSTGAGTNVFMDITSLTIAKRAGIKIFVINGFDLNEYKNILYNEKCGGTVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6C2</accession>
    <name>A0A1V0N6C2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4-type Zn-finger-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ZPR1 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1828</name>
        <name evidence="7" type="ORF">HLB00_09765</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000435">
        <property type="protein sequence ID" value="NOL61103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886978.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6C2"/>
    <dbReference type="STRING" id="74969.FAD_1828"/>
    <dbReference type="GeneID" id="16025108"/>
    <dbReference type="KEGG" id="fai:FAD_1828"/>
    <dbReference type="OrthoDB" id="14924at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004470">
        <property type="entry name" value="ZPR1-like_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00340">
        <property type="entry name" value="zpr1_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL61103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="166" mass="18821" checksum="F64049492EE8C463" modified="2017-06-07" version="1">MDEKKTESRCPNCNSFLYYIEADNEIPYEGKITIHTYVCKNCNYKNITIDRHEKGEPKIIKFKIKNKNDLKTIVYRSPDASVHIPELEAEISPGIASKGYITTIEGILTSIKEKLSIMGDDENINVLRQRIEGIISGAEESVTIILDDDSGQSRINSSRVEIIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6E5</accession>
    <name>A0A1V0N6E5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">gluconate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mandelate racemase/muconate lactonizing enzyme family. GaD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.39" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143106.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6E5"/>
    <dbReference type="STRING" id="74969.FAD_1816"/>
    <dbReference type="GeneID" id="31677306"/>
    <dbReference type="KEGG" id="fai:FAD_1816"/>
    <dbReference type="OrthoDB" id="42605at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047929">
        <property type="term" value="F:gluconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03316">
        <property type="entry name" value="MR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="391" mass="43453" checksum="EB6BA258FCDEFCBB" modified="2017-06-07" version="1">METIKNIEIYELGSPEEKSSPWSSTILILKLTSSDGRVGFGEAPTTMMTLPVKESMNEVARVFQGKNYFDIEKNLRDYYRNAFYVAKSVEETAALSAFEIASWDLIGKNLGSPIYNLLGGRFNEKIRGYANGWYSDCVSPEDFVSKAKSLVSRGYSAFKFDPFGSNYDKITVDGVKKAQEIVAQMRSSLGEGVDLLIECHGRFSPKYAIMAGKALEEYNPLFIEEPIHPELERFLPEFRARVDIPVALGERLLNKEDFARYISDGMVDVIQPDLTNSKGILEAKKIGAIAESFGISVAYHNAFGPVQTAATLNVDYTLPNFLIQESFEESWPSWKKNLFTGYSVENGTMALSGKPGLGIEVNEKLLENSKVSGMEPLGTEPPWVVSGTFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1F2</accession>
    <name>A0A1V0N1F2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Large ribosomal subunit protein eL21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl21e</name>
        <name evidence="7" type="ORF">FAD_0045</name>
        <name evidence="8" type="ORF">HLB00_02680</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000086">
        <property type="protein sequence ID" value="NOL59739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841567.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1F2"/>
    <dbReference type="STRING" id="74969.FAD_0045"/>
    <dbReference type="GeneID" id="16025191"/>
    <dbReference type="KEGG" id="fai:FAD_0045"/>
    <dbReference type="OrthoDB" id="6295at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_eL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_eL21_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003303">
        <property type="entry name" value="PRK04306.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD83980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="98" mass="10922" checksum="B360E2277AEE53CD" modified="2017-06-07" version="1">MTRMSNGTRSGSRSKLTKKIKQRGMPKVNSLLKKFEIGETVAVVIEPAIQKGMPFHNFQGRTGKITGMQGSCYILKIKIGNTERKIISAPVHLKRLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1G1</accession>
    <name>A0A1V0N1G1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit Rpo12</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpo12</name>
        <name evidence="8" type="synonym">rpoP</name>
        <name evidence="9" type="ORF">FAD_0043</name>
        <name evidence="10" type="ORF">HLB00_02690</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000086">
        <property type="protein sequence ID" value="NOL59741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887054.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1G1"/>
    <dbReference type="STRING" id="74969.FAD_0043"/>
    <dbReference type="GeneID" id="16025189"/>
    <dbReference type="KEGG" id="fai:FAD_0043"/>
    <dbReference type="OrthoDB" id="129238at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00615">
        <property type="entry name" value="RNApol_arch_Rpo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023464">
        <property type="entry name" value="Rpo12"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001605">
        <property type="entry name" value="PRK00398.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD83978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="43" mass="5010" checksum="8E15D4B4D64AC943" modified="2017-06-07" version="1">MYKCIRCGRQLEKTFGTTDIECECGSRVFIKERPSVEKIVKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1H2</accession>
    <name>A0A1V0N1H2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0005</name>
        <name evidence="6" type="ORF">HLB00_07120</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000258">
        <property type="protein sequence ID" value="NOL60598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887017.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1H2"/>
    <dbReference type="STRING" id="74969.FAD_0005"/>
    <dbReference type="GeneID" id="16025151"/>
    <dbReference type="KEGG" id="fai:FAD_0005"/>
    <dbReference type="OrthoDB" id="12184at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00317">
        <property type="entry name" value="cyclophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD83941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="151" mass="16728" checksum="25E9EACF989AF83E" modified="2017-06-07" version="1">MATAVLETSMGDIEIELFEKDMPVTAGNFRKLVEQGFYNNTIFHRVIPDFMIQGGDPTGTGMGGPGYKIKDEFTKNNRNDRGTIAMANAGPNTGGSQFFINVVNNNYLDKMHPVFGKVVKGLDVADKISKAKRDRNDKPLEKIVIKKAFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1H6</accession>
    <name>A0A1V0N1H6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative RNA-associated protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ribosome assembly factor SBDS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0038</name>
        <name evidence="6" type="ORF">HLB00_02715</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000086">
        <property type="protein sequence ID" value="NOL59746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141258.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1H6"/>
    <dbReference type="STRING" id="74969.FAD_0038"/>
    <dbReference type="GeneID" id="84218529"/>
    <dbReference type="KEGG" id="fai:FAD_0038"/>
    <dbReference type="OrthoDB" id="84504at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF4">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SDO1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="3">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="4">
        <location>
            <begin position="164"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD83973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="230" mass="26083" checksum="D449A74AD3A74197" modified="2017-06-07" version="1">MVNTDEAVIARFEYDSYKFEILVDPDAASRIRAGKIDIENDLALPEIFKDAKKGERTNEEILKRVFKTTDIGQIAIEIVKRGQIQLTTEQRKEMLELKRKQVINEIVREAINPQTNTPIPVTRIEAAMEEAKVRIDPFKSVDEQVQAVLKAIRPLIPIRMEKARMAIRLTGDAYGRLYGDISRMGTILKEEWSNAGDYICVIEIPAGMQGDLIDLINRKTSGDADVKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1I9</accession>
    <name>A0A1V0N1I9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141252.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1I9"/>
    <dbReference type="STRING" id="74969.FAD_0032"/>
    <dbReference type="GeneID" id="31675545"/>
    <dbReference type="KEGG" id="fai:FAD_0032"/>
    <dbReference type="OrthoDB" id="110773at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053172">
        <property type="entry name" value="Tn903_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053520">
        <property type="entry name" value="Transposase_Tn903"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033579">
        <property type="entry name" value="transpos_IS5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631:SF3">
        <property type="entry name" value="ISSOD12 TRANSPOSASE TNPA_ISSOD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="129"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="308" mass="36266" checksum="71316E168938D344" modified="2017-06-07" version="1">MTPQINNKINRSIKRYWIGSNRRWEKYNESLADRIEYLADLSFIRDYDSLLEENNNGKIGHPYKVPDALIMYLARLRSIFNVPFRSLEGMLRSLAIIANIKSISYSEIFRRIRRIKPDLNSNINSKLDCIIDSTGSKITIRGDYLRHKWHRKRNGWLKLHVIISLKDVTVLSFTITDEHTHDSKAARKLLSKMKNNILRIFGDRGYDSKYIYNMFGYNAIIPPRKNASTKSRGSSTRARIVRYIKKNSMEQLKENNSYGKRWIVEIYFSGLKRVMTEIIKAKKIEYIIQELALKVVNYNIMRGMTHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1J7</accession>
    <name>A0A1V0N1J7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5-oxoprolinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Hydantoinase_b/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0029</name>
        <name evidence="3" type="ORF">HLB00_07560</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000279">
        <property type="protein sequence ID" value="NOL60684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141250.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1J7"/>
    <dbReference type="STRING" id="74969.FAD_0029"/>
    <dbReference type="GeneID" id="84218519"/>
    <dbReference type="KEGG" id="fai:FAD_0029"/>
    <dbReference type="OrthoDB" id="8261at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF23">
        <property type="entry name" value="HYPOTHETICAL 5-OXOPROLINASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="510" mass="56503" checksum="61BCECFAE8EC5390" modified="2017-06-07" version="1">MTDWEIVGKATQFIAEEMGVALKRSAISPNIRERMDHSCAVLDSEGRIIAQAEHIPVHLGSFKIGSRNIINYMREKSITLKENEMLITNDPYISGTHLNDVTIIAPVYDNDKLFCYVINKAHNVDVGGPVFGSLNPEARNLYQEGLIIPPVVITPDIIRMILANFKDPETANGDLNAQISANRMGINRIKELMAKYGPDEIKSSWNSLIDHSRELSLMALKEWEAGEYKAIDYLEKGIEKINININLKISAGGVVADFEGTHGEIEYPLNAVEGVTFSAVAYAIRSAMQYSIPTNDGFYSVITIKAPERSLVNPERNYPVSGGNVETTQRIADVTLRALSEFLYYIPAASSGTMMNLMLGGKYGNKYWSYYETIGGGNGGRYDSNGESGIHSNMTNTLNTPVEIAEKEYPFFFTKNNLRKNSYGKGKYHGGEGIVRSFKVRSRTYISVIADRFIIPPWGLHGGFPGKTGKIYILSNGRKKSMPSKFSTVLEENDEVVIETPGGAAYGEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1K3</accession>
    <name>A0A1V0N1K3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-7-phosphoheptulonate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887107.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1K3"/>
    <dbReference type="STRING" id="74969.FAD_0099"/>
    <dbReference type="GeneID" id="16025244"/>
    <dbReference type="GeneID" id="31675611"/>
    <dbReference type="KEGG" id="fai:FAD_0099"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052899">
        <property type="entry name" value="Class-I_DAHP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006421">
        <property type="entry name" value="PRK08673.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009239">
        <property type="entry name" value="PRK12595.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43018">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43018:SF2">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="2">
        <location>
            <begin position="13"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="260" mass="28619" checksum="B643450D42F6B91D" modified="2017-06-07" version="1">MVDIKINDEIRLTDDKFLMIAGPCSVESEEQIIRVATQLRKIGVNVLRGGAFKPRTCPDSFQGLGEEGLKLLAKARDATGMAIITEVMDMDELPLVAEYADILQVGSRNSQNFSLLKKISRYDKPVLLKRGFGNTVDELISSSKYLSMNGNKRIMFSERGIRTFEQSTRFTLDISAIPVLHEKTEYPVIIDPSHPAGVNRYVEPLALGGTAAGADGLMIEVHPDPPKALSDSAQQLTVPQFQNLYTKVKNINAVLGKTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1N4</accession>
    <name>A0A1V0N1N4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of amino acid metabolism, contains ACT domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141355.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1N4"/>
    <dbReference type="STRING" id="74969.FAD_0116"/>
    <dbReference type="GeneID" id="31675628"/>
    <dbReference type="KEGG" id="fai:FAD_0116"/>
    <dbReference type="OrthoDB" id="30884at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="23127" checksum="7CCCFAA0C62CCA8D" modified="2017-06-07" version="1">MQLVFDEYFKIYPVKKRIVEGLYASGISIVNEKFYLNNIEIPLSSIATTLKVNRRTLYETIKFVNKNPVVKEIMENVSVLPDTKKISLLMKNEVVTIFIDKGMYFKVVPEIMRILEKQMSNIKEIYSINSDYETSFIRLIFYNEVEEEVFKKFNNVTGINKILIDSPREIDVICDKCEIKICPHKISTSFKEHSIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1N9</accession>
    <name>A0A1V0N1N9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VIT family Fe2+/Mn2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141290.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1N9"/>
    <dbReference type="STRING" id="74969.FAD_0071"/>
    <dbReference type="GeneID" id="31675583"/>
    <dbReference type="KEGG" id="fai:FAD_0071"/>
    <dbReference type="OrthoDB" id="42847at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01044">
        <property type="entry name" value="Ferritin_CCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039376">
        <property type="entry name" value="Ferritin_CCC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rr_diiron-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Rubrerythrin diiron-binding" evidence="6">
        <location>
            <begin position="16"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="329" mass="37051" checksum="6A214E0226BE0528" modified="2017-06-07" version="1">MVGTSNSRYQIKFLRDELTDMIFYTYMYRNTEDPELKENFKQLATIENEHANFWGQSLKSSNVDINKITYRKTKYFFMKIIRAIVGKNLIINLLEHGEYQSIRKYKTYLESYKQEDDYKKKVNDLISSEMQHEEIFANKISKSVKNIQKSRDFLYGMSDGLVEVLATLVGLSAIITSHIDIALSGVVVGISGTFSMTLGAYLAQKSESEYKIAMLNRKHIFSRSKGVENMINQYSSEATISALNTAISYITGAVIPILPFVFFQKYMAVALSVILVFIAQMISNSIVALSLNTPILKSGLRASLLALGAAAATFAAGEIFHIIFHISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1S8</accession>
    <name>A0A1V0N1S8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841599.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1S8"/>
    <dbReference type="STRING" id="74969.FAD_0158"/>
    <dbReference type="GeneID" id="16025307"/>
    <dbReference type="KEGG" id="fai:FAD_0158"/>
    <dbReference type="OrthoDB" id="6121at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_uL3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003261">
        <property type="entry name" value="PRK04231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="NCBIfam" id="TIGR03626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="330" mass="37253" checksum="5775D7D02411367F" modified="2017-06-07" version="1">MATPHHSRRGSMAYYPRVRAKKIGAEIRSWPEIEGKSKIQAFAGYKVGMTHIQVTDYRKTSVTAGKTIMVPVTVVEVPPINVIAIRYYEDGDNGLQVFAEKRAEQIEKEVFKRIPEIKNKEPKNIEIKDVADVRLLVNTNPQLVTGIPTKTPEIFEVRISGSTIADRIKLAEEKLGKELHFDDFNSTGSFVDVISVTKGKGFQGVVKRFGVKLLPRSNRKHRRMIGTLGPWHPDWVRNTVPQAGQVGLHQRTIHNIRIMKTATKEQVDEINVKGGFLKYGLVRNDYILLYGSISGPSKRLIKMRDPARQAVPNTDKVDITYISRESKQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1U0</accession>
    <name>A0A1V0N1U0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminoacyl-tRNA(Ala) deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">alaX1</name>
        <name evidence="6" type="ORF">FAD_0119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141356.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1U0"/>
    <dbReference type="STRING" id="74969.FAD_0119"/>
    <dbReference type="GeneID" id="84218609"/>
    <dbReference type="KEGG" id="fai:FAD_0119"/>
    <dbReference type="OrthoDB" id="11392at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053424">
        <property type="entry name" value="Alanyl-tRNA_Edit-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040865">
        <property type="entry name" value="a_tRNA_ed_AlaXM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="238" mass="27000" checksum="7130B92A629FA405" modified="2017-06-07" version="1">MTEKLYYNDMYGREFDASVISVEDNYVVLDKTLFYPTSGGQPNDTGILKTSNGEMKIIDVIQEDGEIRHIADRIENVTPGAHVHGVIDWDNRYIHMRYHTAVHIIDGVVNNDYKNGLLTGGQIYDDHARVDFSFDIIDRDLITQIISKAQDVINSGRKVFAREISSEEALKIPGLARTEPGRQLIEKLPVVRIIEIENFDFQADGGTHVKNTEEVGKIEMLKIENKGKGHKRLSFKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1X8</accession>
    <name>A0A1V0N1X8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887180.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1X8"/>
    <dbReference type="STRING" id="74969.FAD_0175"/>
    <dbReference type="GeneID" id="16025323"/>
    <dbReference type="GeneID" id="31675686"/>
    <dbReference type="KEGG" id="fai:FAD_0175"/>
    <dbReference type="OrthoDB" id="7144at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000008">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019907">
        <property type="entry name" value="Ribosomal_uL6_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004037">
        <property type="entry name" value="PRK05518.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03653">
        <property type="entry name" value="uL6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="7">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="7">
        <location>
            <begin position="96"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR03653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="181" mass="20583" checksum="BA68FF1BC2D92F21" modified="2017-06-07" version="1">MVNWKDKMELKIPEGISLDIDGTVINVKGKLGEASRNFRDKYVKVYKKENSIIIAVSKENKFTNGIIGTWYSELKLVFHGVSNGFKYEMKIDFTHFPMRVSVRGNELHVENFLGGKAPRIAKIKNCKVSVKGDRVIIEGIDKRDMGDTAANIERATYIKHFDARVFQDGIYLLKGVNPDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1X9</accession>
    <name>A0A1V0N1X9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps3</name>
        <name evidence="10" type="ORF">FAD_0164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds the lower part of the 30S subunit head.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1X9"/>
    <dbReference type="STRING" id="74969.FAD_0164"/>
    <dbReference type="KEGG" id="fai:FAD_0164"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02411">
        <property type="entry name" value="KH-II_30S_S3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000001">
        <property type="entry name" value="30S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_A">
        <property type="entry name" value="Ribosomal_uS3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027488">
        <property type="entry name" value="Ribosomal_uS3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="223" mass="24979" checksum="18E8CD45682B88A9" modified="2017-06-07" version="1">MMKEKKFVSDNIKKLLVTEYLQSENDSAGFGGMDMKRTPFGTNITLYVNRPGLVIGRHGSKIKAMTSILETKYGLESPQIEVKEVENADLNPQVISKKIALSLEKGWNYRKAGNTTLRRIIDQHARGVLIRIGGKISGERARTQKFMYGEIKYSGEPARAGVITGYSVAMLKTGAIGIYVRLLRQDYHLPDEISINTERKIPVPDKKSMPEESKEVEEDGTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N215</accession>
    <name>A0A1V0N215_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141400.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N215"/>
    <dbReference type="STRING" id="74969.FAD_0203"/>
    <dbReference type="GeneID" id="31675713"/>
    <dbReference type="KEGG" id="fai:FAD_0203"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052962">
        <property type="entry name" value="AA_Transporter_AGT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47547:SF1">
        <property type="entry name" value="ASPARTATE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="582" mass="62188" checksum="84D4488C253E49DE" modified="2017-06-07" version="1">MADSISEKTVIANSKLQDKRLKKALNTWDLYFLSLGGIIGSGWLFAAAASAGTTGPAAILSWIIGGVIVLFIALVYAELGSMIPRTGAISRYGHYSHGGVAGLFFGWTYFLSAVSVPAIEAEAVITYASSYIKGLSYSAPNPINPSATVALLTGLGILLAAILIVAFFALNYAGVRIMGKTNTGMTWWKLIIPSITIVMLAFLVFHTSNFTSPALGGFLPGNNSATIFEAVSTDGIVFSFLGFRQALDYGGEAKTPQRSIPRATIFSVLTGIVVYVLLQVVFIGAIDPTKLAAAGGWFGLVSSTPTTYAASVVAAPFAFLAKSSGIFALVVLTYVLYADAYVSPAGTLNVYAGTSTRTLFGLAEIGYFPKQLSVVSKKTHVPVLPIILSVIIGIIFLAPFPSWYALVGLITGATAFTYIVGGSALMVLRREADALKRPFKLPFAKILAPIAFIGATLIVYWSGWPTIPYLAIGIFLGIVVYLIILATHKVENVFTKENIKAGWWVPGFILVLTLLSYLGEGDYGGTNTLPYPYDFVVVIIVAIIFYLISIRSGYRTEEISDIIESGTQYIQEEDVTTTAGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N225</accession>
    <name>A0A1V0N225_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate--tRNA(Asp) ligase</fullName>
            <ecNumber evidence="9">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="9">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="9">D-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">aspS</name>
        <name evidence="11" type="ORF">FAD_0280</name>
        <name evidence="12" type="ORF">HLB00_06460</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000224">
        <property type="protein sequence ID" value="NOL60474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141451.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N225"/>
    <dbReference type="STRING" id="74969.FAD_0280"/>
    <dbReference type="GeneID" id="84218778"/>
    <dbReference type="KEGG" id="fai:FAD_0280"/>
    <dbReference type="OrthoDB" id="5908at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="133"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="9">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="398"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA discrimination" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD84202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL60474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="427" mass="49353" checksum="B39FAC3E49064559" modified="2017-06-07" version="1">MRTYIADIKTLDDGSDVTIKGWVQETRKIKNLMFIIMRDNTGSIQVTAKKDSMKNYDQLYDITRESVISVYGTLNKKSISKSGMEIQGIEIEILSIADTPLPLGVIDRVSADFDTRLNNRFLDLRKPEHLLIFQFESQLLFGIREFMNKENFIEVHTPKIVAAATEGGADLFRVEYFEKNAFLNQSPQLYKEILIASGFDKVFEVGPAFRAEKENTVRHLNEFTSIDMEAAFIDDKKAMEYLENAISYAVNRNIDLMHTKLEEYGYHLEKIETPFPRISYEDGIKYLNDHGLKLNFGDDFSPEANKILAEKFNGFYFITGWPSDMRPFYTHPDTNPALTKSFDLQLNDIEVTSGAQRIHNYKMLEDNFMKKGLNKNDFEFYEKAFKFGMPPHAGWGLGLERLVMNLLHLNNVRESTLFPRDRTRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N231</accession>
    <name>A0A1V0N231_9ARCH</name>
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        <recommendedName>
            <fullName evidence="2">UPF0179 protein FAD_0288</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0179 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
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    <dbReference type="STRING" id="74969.FAD_0288"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="UPF0179"/>
    </dbReference>
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        <property type="entry name" value="UPF0179 PROTEIN MJ1627"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPF0179 PROTEIN MJ1627"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03684">
        <property type="entry name" value="UPF0179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="146" mass="16647" checksum="1D25D294834F4105" modified="2017-06-07" version="1">MIKLNKISLIGVNLAKKDLVFTFRGPLAGKCDECKIRNVCFNLEPGKSYRIKEVKEQINPCFIYDTNKVSTIDVEEVENTYNVQNGKRLMEGSSMELRSMKCDYLTCPNIEKCNLLNLKGNKKIVVKKIIGKISCPKGYDMREVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N251</accession>
    <name>A0A1V0N251_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N251"/>
    <dbReference type="STRING" id="74969.FAD_0250"/>
    <dbReference type="KEGG" id="fai:FAD_0250"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="167" mass="18605" checksum="4A5C0F60FA30A860" modified="2017-06-07" version="1">MEYTGKIMTSRGHVFQFNGQGTHFLSIAIVAELSLLAVQFIIGMWMNLFAVYPSYNNAFPMYGMMDIMFSIPELMVHMMIGVLIGLLSLMIFMMTLMLGDYKSMVVSAIASISILLAGLSGLEFIFSNFQNNTFSFTMSIGFIIAVISFVFLLYSISIESKAAHLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N291</accession>
    <name>A0A1V0N291_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Archaeal Lon protease</fullName>
            <ecNumber evidence="15">3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-dependent protease La homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">lonB</name>
        <name evidence="17" type="ORF">FAD_0351</name>
        <name evidence="18" type="ORF">HLB00_01480</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Berkeley</strain>
            <strain evidence="19">Y</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13 15">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cell membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the peptidase S16 family. Archaeal LonB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="15"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000040">
        <property type="protein sequence ID" value="NOL59509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887370.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N291"/>
    <dbReference type="STRING" id="74969.FAD_0351"/>
    <dbReference type="GeneID" id="16025516"/>
    <dbReference type="GeneID" id="84218849"/>
    <dbReference type="KEGG" id="fai:FAD_0351"/>
    <dbReference type="OrthoDB" id="64652at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004663">
        <property type="entry name" value="Lon_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046843">
        <property type="entry name" value="LonB_AAA-LID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00764">
        <property type="entry name" value="lon_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20436">
        <property type="entry name" value="LonB_AAA-LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="16">
        <location>
            <begin position="440"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ARD84272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="NOL59509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="657" mass="71256" checksum="D903C777A041ADCF" modified="2017-06-07" version="1">MDSNNDDVEEWISKQGIKTTKEIEVPKLLFNQVIGQEHAGEVIQKAAMQKRHVLLIGEPGTGKSMLAQSMVDFLPKEDLEDVLCFPNPEDSNKPKIKTFPAGKGKEILRQYQIKAEREKKDRSKSLLFIVLSIILLGAILAIYLWVSGNTAVAIEVMFLAVIGAAFLYIIMAMNPAARMERAMVPKLLVGHNPNDKPPFIDSTGAHSGALLGDVRHDPFQSGGLETPAHERVEAGNMQKADKGVLFIDEINLLRPEDQQALLTAMQEKHFSISGQSERSAGAMVQTEPVPCDFVLVAAGNLDAIRNMHPALRSRIRGYGYEVYMNDTMEDSDDNRKKIVQFIAQEIAKDKKIPPFDDGAIIEILKEAQKRGGRKGRLTLRLRELGGLVRVAGDIAVTNKQPIVTADDVNQARNLSKPVEQQIADRAIEVKKLYKMFTGNGSAIGKVNGLAVMGSSDMSDFTGVVMPIVAEVTQAQHPHNGGVYATGKLGEIAKEAVQNVSAVIKKLSGKNVSDVDIHIQFIGTYEGVEGDSASVSIATAVISSLESIPIDQTVAMTGSLSVRGDVLPVGGVTAKVEAAIDTGLAKVIVPASNFNDIILDEAHKGKIQIIGASRIEEVLENALIMGPEKDKFLQKIKDIVNPATDIKKPAQRRGTHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2A0</accession>
    <name>A0A1V0N2A0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L40e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0331</name>
        <name evidence="6" type="ORF">HLB00_02000</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000053">
        <property type="protein sequence ID" value="NOL59607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887349.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2A0"/>
    <dbReference type="STRING" id="74969.FAD_0331"/>
    <dbReference type="GeneID" id="16025495"/>
    <dbReference type="KEGG" id="fai:FAD_0331"/>
    <dbReference type="OrthoDB" id="45138at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023657">
        <property type="entry name" value="Ribosomal_eL40_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003161">
        <property type="entry name" value="PRK04136.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L40E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL40" evidence="4">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="49" mass="5697" checksum="4FF8CF6E00A071BC" modified="2017-06-07" version="1">MPFAEAIERRLTRKICMKCYARNSINATKCRKCGYTGLRVKSKERKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2C2</accession>
    <name>A0A1V0N2C2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase family III protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141557.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2C2"/>
    <dbReference type="STRING" id="74969.FAD_0381"/>
    <dbReference type="GeneID" id="31675890"/>
    <dbReference type="KEGG" id="fai:FAD_0381"/>
    <dbReference type="OrthoDB" id="28444at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="313" mass="35510" checksum="A9FB53FCC69BE592" modified="2017-06-07" version="1">METVIDATRLIPGAITTRILSDRGYNVIKFEDTGKGDYMDELSPGANDFLNHGKKSICVDLKTSEGKKIFYRLIKNASVFIENFSEGVTERLGIDYLTLHRLNPQLVYCSIKGYRENPELPAHDINFTAFSGIGITLPVQIADAGSGIYAAMEIINHLKNRDYSKVTVNMSDIPLYFNAYNLFTENNVLNGKFPCYRIYQVSDGKVALGCLEQKFWANFTEAIQRKDLENSRLNLNINKEIENIFLQYNSMEILELGRKYNFPVSAVRAKEEIISGLNSEHAPGHGENTDEILKNNDYKNDEIDNLKNKKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2D1</accession>
    <name>A0A1V0N2D1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951093.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2D1"/>
    <dbReference type="STRING" id="74969.FAD_0324"/>
    <dbReference type="GeneID" id="31675833"/>
    <dbReference type="KEGG" id="fai:FAD_0324"/>
    <dbReference type="OrthoDB" id="84443at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF209">
        <property type="entry name" value="GALACTOLIPID GALACTOSYLTRANSFERASE SFR2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="483" mass="56304" checksum="CE7DCEAF64DA70C5" modified="2017-06-07" version="1">MLRKFPDNFMFGTATSPFQVEMGRSDNSISSESDWYKWSHDSNIIQKTYVSGDFPDDGPDFWNNYKRFIDASIDMGNNSIRIGIDWARIFKTSTESVDAVASKNEKGDVYAMSFPDNFIQRMDSIADNDAVKHYAEIMEYIKARNLKLILTAYHWPLPIWLHDPVKCNQDFANCREKGWADKATVEEFGKYTYYLYNKFHRYVDIWNTLNEPNIIAINGYVYGNLEGFPPGLSNFSIAVSVMRNLAYAHNIAYKIIKALDHSSQVGINVAVPYFQPEMDTPENRFIVNYVKHIFYDLYLNSALYGNFDNSLSGIFNESRPSEFAGTDFIGIDYYSRIRVRYVDNDNVDLRYRFAFLPCSKCSDNYWDIFPEGIRNVSRSVFNHYRKPVMILENGVADAEGSLRKEFIEKHLIELHKAIKEDYIPVKGYFHWSIVDNYEWARGYKDKFGLYKINNGEFVKTEASEFYSKICHDHGVEDSDFKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2H2</accession>
    <name>A0A1V0N2H2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="10">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">glnS</name>
        <name evidence="10" type="synonym">gltX</name>
        <name evidence="14" type="ORF">FAD_0370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141545.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2H2"/>
    <dbReference type="STRING" id="74969.FAD_0370"/>
    <dbReference type="GeneID" id="31675879"/>
    <dbReference type="KEGG" id="fai:FAD_0370"/>
    <dbReference type="OrthoDB" id="10470at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003169">
        <property type="entry name" value="PRK04156.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="95"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="402"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="547" mass="62737" checksum="A81DF42DCF10C800" modified="2017-06-07" version="1">MQQEIRKQVIKNAYMHGGKADISSVVGKLISINPDAKKDMKTLMGTIRKYVDEVNAMGADQLEEIVNTEYPDILIKEKKEERHELPDLPGVNGSVVMRMAPSPSGPLHIGHSRMAILNDEYVKRYGGKLILRIEDTNPGNIDPDAYTMIPEDLKWLGVDVTETVIQSSRMEFYYSEAKRMISEGYMYVIEENQQEFHDLKLKKVPVKERDADPSVNLEKFDKMISGHYSEGEAAVVMKTDINHPNPSIRDWIAFRINTTEHPLTGSKYSVYPTMNFSVSVDDHYLGLTHVIRGIDHLVNTEKQKYVFMYNNWKIPEYFHYGFITIPDTILKTTIIKEGIKSGKYSGWDDIRLGTLKALKKRGYNPETFRKYWVRSGMNKSNATFSWEIFDSMDREIIDYNTERYSFVPHPELISLQNAEPLKSHALLHPQRPDSGFREYSIPAQASVYFPGDEIDKINEGEVIRLKDLCVAVKKGNKLVYSNIEPEGRVKIIQWAPENSGDIQIFHPDGNIDKGKLEPLATEKRGVVQLERYGYVNLDGKNGYFLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2P2</accession>
    <name>A0A1V0N2P2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2P2"/>
    <dbReference type="STRING" id="74969.FAD_0499"/>
    <dbReference type="KEGG" id="fai:FAD_0499"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF7">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN YECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="191" mass="21158" checksum="645736E945D5E988" modified="2017-06-07" version="1">MGLEIDKKSTALVVIDLQKGIASMGRNLVPYDANTVIKNASELAESFRKNDMPVFLVHVVPDKRAMLNVLADDSAWSGSAEMPPDFSDIVPELGPRDNDVVISKKQWGAFYGTDLELRLRRGGIKTIVLCGISTTHGVESTARFAYEMGFQQIFAEDAMTAMTKEMHESTINNVFKKMGRVRKTSEIVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2P3</accession>
    <name>A0A1V0N2P3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Replication factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2P3"/>
    <dbReference type="STRING" id="74969.FAD_0452"/>
    <dbReference type="KEGG" id="fai:FAD_0452"/>
    <dbReference type="OrthoDB" id="335252at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="369" mass="41871" checksum="0D5A8DC687B61FE3" modified="2017-06-07" version="1">MAGPNGKPLNKHKGYEIMKINEMQGNLNNVEGKVKILSVDKREITTSRGDTVYYYGLAGDETGVLPYTAWEFPAPIKPGDVVQIKYAKTKVYNDRMRLYFDSKTEIMLKPGEEMEVKNTYKDVKLMDLTTKNPFVAVTGKISNMSGKEYNKAGKTFIIYNGFIEDDTSRVRISSFGKPLENGKVYRIVGARVSEFNKQLEISIGDKTEVFIENEDMDFQRYYKLFEVDNPAGGITIMGFIITLGTKSGIIKRCSECNKPLSNGVCPDHPEKPTKLDIFSYFTLDDGTKYIQCIAGKNAIMPFIGIKEEELPHYAGEIYRMLEEKLYGHAVKINADFIKNEEDLSLRVNSITNIEREDISREIEANQQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2R0</accession>
    <name>A0A1V0N2R0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferrochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141619.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2R0"/>
    <dbReference type="STRING" id="74969.FAD_0464"/>
    <dbReference type="GeneID" id="31675973"/>
    <dbReference type="KEGG" id="fai:FAD_0464"/>
    <dbReference type="OrthoDB" id="56534at2157"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="294" mass="33819" checksum="FAAC04CFAFB039C8" modified="2017-06-07" version="1">MKKVILLSYGSPERIDDVPEYLSGIFNGKPVPEKIMEENIKKYEMVNGISPSNQIIKNLKDKLGKLLARYGDFEIIDAYKHWHPGIEETVSSLDADYEEIIALPLFAFKSNNIRKSYEIPVKKAMEGKNMKLRFINGLDYSILASMWVSEISKYVYDFDNFLFTAHSLPLIDDESDYQASLERNAGKISDMLGIEKYYTAFYSQGPHGKWIEPSIYSKIDLFKEDKINNLLVSPIGFLYEHLEILYDLDVKYKEFLESQGIKYARARTPSDSDGMAILLKNAIMGVEGDKENYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2S0</accession>
    <name>A0A1V0N2S0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887529.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2S0"/>
    <dbReference type="STRING" id="74969.FAD_0474"/>
    <dbReference type="GeneID" id="16025678"/>
    <dbReference type="GeneID" id="31675983"/>
    <dbReference type="KEGG" id="fai:FAD_0474"/>
    <dbReference type="OrthoDB" id="7146at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09878">
        <property type="entry name" value="PIN_VapC_VirB11L-ATPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010335">
        <property type="entry name" value="PRK13764.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF147">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PIN" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="479"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00046345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="607" mass="67833" checksum="C2DBD9B8DEA5E5C1" modified="2017-06-07" version="1">MDYVPDTSVIVSGKFREYVAGKNDVRVILAEAMIAEIEHQANEGRSIGFTALEELKKLRELSDSGKIYIDIMGNRPMEWQIKNAHSGEIDNIIRNIALDNAATLVTGDHIQSIIASIKGINVIYIKGEEKDARDIQEFFDEYTSSVHLKAGMKPLIKTGKPGEVVLKELDYVVSNDELERIAYNIVQRGKFEDQSFIEMDMFGATVIQLKNLRIVITRPPFSDIMEITAVRPVVKTSIEDYKLDKRVMDRLQNKAYGILVAGSPGAGKSTFVTALAEYYASQNKIVKTMEKPRDLQVNDSITQYTTLEGDMEKTGDILLLVREDYTVFDEMRVTSDFKVYSDLRLAGVGMVGVVHSTRAVDAIQRFVGRIELGLIPQVVDTVLFIDGGKVSQVLTTDYQIKIPYGLNQEDLARPVIVIRDFLKNKPVSEIYTFGDQVVVIPVGDEKNGANPLFAIAAAKIREDMMKLLETDHVDVQIVSEGRVIIKVPDAKIPRLIGRKGETVTALEKSYGLKIDVDTLSDDVNVMQDALIEIKNKTIFIDVGSRNRPVKLYVDGIAMLSARSSAKGMIKLRINSDTGNTVYKYIKQGKKLQYMVMEESEPSSSHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2U3</accession>
    <name>A0A1V0N2U3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">2-oxoacid ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_0568</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141695.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2U3"/>
    <dbReference type="STRING" id="74969.FAD_0568"/>
    <dbReference type="GeneID" id="31676073"/>
    <dbReference type="KEGG" id="fai:FAD_0568"/>
    <dbReference type="OrthoDB" id="30755at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03375">
        <property type="entry name" value="TPP_OGFOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051457">
        <property type="entry name" value="2-oxoacid:Fd_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008820">
        <property type="entry name" value="PRK11866.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48084:SF4">
        <property type="entry name" value="2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48084">
        <property type="entry name" value="2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="10">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate ferredoxin oxidoreductase beta subunit C-terminal" evidence="11">
        <location>
            <begin position="199"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="285" mass="31653" checksum="BEC66D0B114283B7" modified="2017-06-07" version="1">MIPVTEYKGKVAPDWCPGCGNFSQLRAITMALSELDIKPENTVISSGIGCSSNMPEFINTYGFHGLHGRSLPVAEGIKWANKNLTVIAYGGDGDGFFEGSQHFYHAAKRNVNMTYMVSDNQVFGLTTGQASPTTPIGRITKSTPDGNIEPPFNPLHYALSAGATFVARGLSGNIKQLAELTKAAIQHKGFSFIDVFSPCVTYNKVEGYEFFRKTTYELKDNNRKDFYEAFKHASEWGEEANSIPIGILYDVDAPVYEDVDETLKEYNLKDTAPYKLTEEDLEEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2W1</accession>
    <name>A0A1V0N2W1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141647.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2W1"/>
    <dbReference type="STRING" id="74969.FAD_0513"/>
    <dbReference type="GeneID" id="84217096"/>
    <dbReference type="KEGG" id="fai:FAD_0513"/>
    <dbReference type="OrthoDB" id="25212at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005033">
        <property type="entry name" value="PRK06445.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF140">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE (ACETOACETYL-COA THIOLASE) (ACAB-5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="6">
        <location>
            <begin position="268"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="391" mass="42530" checksum="348CE09A02850226" modified="2017-06-07" version="1">MEDVYIVDYRRIPFSRARPRDPEKDVYNDLRMDKMLSELIRHSVSETKINPAEIEDVITGCAFQAGENWTYGGRHPVLLADLPVSVPAMSLDRACSSSLNATGIGALEIMAGKAGIIISGGMEHMTHVPLGVDNQFIKPNMELMANPKYSKFNMNVSYNMGLTAEKLAKLRNISRDEMDEYSYNSHKRAAKAYEDGFMKGEIMPVTVNGNTITSDLGIRKDTTLEQIKSLKPAYSEDGIITAANSSSLNDGASMVMLMSGKKLKEYGLKPMAKIVDFAAAGVDPTIMGEGPVPATKKVLERNNLKPEDIDYWEINEAFAVVVLNAVHAFNLDLNRVNIHGGGISIGHPLGATGARIAGTLARTLEDKKGDLGIATLCVGGGQGYSMLLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2X0</accession>
    <name>A0A1V0N2X0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ni,Fe-hydrogenase III large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887638.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2X0"/>
    <dbReference type="STRING" id="74969.FAD_0581"/>
    <dbReference type="GeneID" id="16025788"/>
    <dbReference type="GeneID" id="31676085"/>
    <dbReference type="KEGG" id="fai:FAD_0581"/>
    <dbReference type="OrthoDB" id="43567at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052197">
        <property type="entry name" value="ComplexI_49kDa-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43485:SF1">
        <property type="entry name" value="FORMATE HYDROGENLYASE SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43485">
        <property type="entry name" value="HYDROGENASE-4 COMPONENT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="2">
        <location>
            <begin position="168"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="384" mass="43279" checksum="550548ADDB96E734" modified="2017-06-07" version="1">MQYYKFGESSGRYIGRSKNYDIYASSIAPAVENTDQFADKNPGEIYFNYGPSAGGLRESVNFSLLTPGETIRDVIIHPEYKKRDLKILGDPVSRALLKVERINGFHAASNSIGYILAVEEALGIENSELNDMRIVELELERIRSNIDVIKGMCESAGFAVPEKQLLYLREEVARIISRAFGHRYFFSVNGFGTVSGDFSTIKLNAIEKQFRDIYDGLLSSKIFLDRIQENGIVKNENSTGPAARAAGFKFDARKDSKSLDYRNFTPVTESGADSFSRLVVRSEEVFEAINIIDSYGVKNIKTRTKNELTGSGKGSARIESPAGDIFYYVNIENGKLNDIQMVSPSYLNLRLFREALKNNNIFTDFFFVWESFGIWISELEVNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N309</accession>
    <name>A0A1V0N309_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141663.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N309"/>
    <dbReference type="STRING" id="74969.FAD_0544"/>
    <dbReference type="GeneID" id="84217142"/>
    <dbReference type="KEGG" id="fai:FAD_0544"/>
    <dbReference type="OrthoDB" id="34275at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF283">
        <property type="entry name" value="GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="37"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="103"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="312" mass="35232" checksum="5A835D0ED57E5059" modified="2017-06-07" version="1">MKVLAILPAFLDIENIKKSIDQIMPGLEIATNTEFEKNDADVVVITTFTPFGKKEMDKFPELKYIQVASTGYNNVDLKEVRRRKILLCNVPVANKDAVAEHVIGMSLALLKNFIPFDQQIKSGNWPLLTNSRELQGKTFGIIGMGAIGIKLVQKLIPFNVGIVYYDPRRLKPEDEELYGLTYLPLDELVKASDIISIHTPLSKETRSMFNESRFNLMKENSIFINSSRGEIVDEKALVKAIKEKNIYAAIDVFGVEPPDFSSELFHVDNVIFSPHIAGVTMESQERFITETIGNVIRYSQGIDPLYKVEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N335</accession>
    <name>A0A1V0N335_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon monoxide dehydrogenase beta subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Xanthine dehydrogenase family protein molybdopterin-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0653</name>
        <name evidence="5" type="ORF">HLB00_03650</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000115">
        <property type="protein sequence ID" value="NOL59927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141752.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N335"/>
    <dbReference type="STRING" id="74969.FAD_0653"/>
    <dbReference type="GeneID" id="31676157"/>
    <dbReference type="KEGG" id="fai:FAD_0653"/>
    <dbReference type="OrthoDB" id="57164at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead" evidence="3">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="668" mass="74003" checksum="7B1D11EE109E45D4" modified="2017-06-07" version="1">MTYQERFVNGKGRYLDDIDLDGMLYMSLVRSPYARAKVKKVEGGLTSKDLKAYYALAEGDHKEPVLAIDEVNYQGQAVAAVFGKNRYESEDLLSTVNVEYEPMDAIHSIDDAKTKPPMYKDTAGNVLSQEDIGVKFNEKDIQYDVKVTDTILLDRVSANPMETRGIVADYRDGILNVYLPSQSIVRSKSGIVNSLGLPPEKVRVFLIDNGGAFGVKALFYPEYIIACYASMKYGKPVKWQETRTEHLQACHAGRGVEGTLTLYAKKDGTITGLDGEVLLDNGPYFVDAASVDLGNVIHEITGPYFIEKAHIVGKYMLTNKAPNGYYRGAGKPEASILMERMMDLLADKLNMDIADVRLKNALEKPFKSPLGLDVNYPTKPFLEDALKYFNYRELSKKEHVGISLFILDEDTAPGESARIIVKDGKVHTYMGGNVSGQGHEMFVKSILSDELSVEQDLISLDLQDTETLSTGVGTWGSKSAMTHGSVLMQAAEELKQQVKEKYGKYSPEILLKHDFDQTSFYKFDYNDNQVNFNLVTSKINEAGDIESLKVGCYYDLGKVLNMTNVMGQTEGGALQAIGEVLSETLRYSEEGQLMTTSITDAGVLTAEHTPEFDIKIVENPSVLKDGAKGLGESPMIGIPEGLARSLETQLHTRINVMPITREFLSRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N338</accession>
    <name>A0A1V0N338_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0600</name>
        <name evidence="6" type="ORF">HLB00_10095</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000443">
        <property type="protein sequence ID" value="NOL61168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887657.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N338"/>
    <dbReference type="STRING" id="74969.FAD_0600"/>
    <dbReference type="GeneID" id="16025807"/>
    <dbReference type="KEGG" id="fai:FAD_0600"/>
    <dbReference type="OrthoDB" id="43988at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06423">
        <property type="entry name" value="CESA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43630">
        <property type="entry name" value="POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43630:SF1">
        <property type="entry name" value="POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="4">
        <location>
            <begin position="59"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL61168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="405" mass="46923" checksum="8FD2CB4FD90F8124" modified="2017-06-07" version="1">MDILQGIGLALIAIGLVYVIYQFPIIYFGYKDFTKYDIDFSKLNEAQFSGLKMYKPMVSIIVPAKNEETVIKRTIESILNQTYTNFELFVVVDNSSDNTYKIAKEYESRDKRVNVFNRPDGKSKASALNFCFEKTKGEVIATYDADTMLLPNTLENAVYGMNYFNVDVLQGYNSYINREENIFTRLAVIDEILVKATLIGRTHFNLFVPVAGSNQYFKRKVIESIGGWDDNFLTEDLESSIRISNARYKSAYLGSAKALQETPASYSEYFRQRTRWLRGYHQVFFHSKKRFSKFTDFDALMIVLAPTFSGILFFGWLYISLLNFYNPFVHSMRTYFISLILISLIIYVVALVLVLIKKRQNFIYIPLIYIYLTLNSLIAIYTLFLEITGAKRVWHKVKKTGKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N341</accession>
    <name>A0A1V0N341_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N341"/>
    <dbReference type="STRING" id="74969.FAD_0671"/>
    <dbReference type="KEGG" id="fai:FAD_0671"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="102"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="209" mass="24775" checksum="1303558409775516" modified="2017-06-07" version="1">MSTVLLLRTGDKFMVNYTDFEDWMYERFSKSTIIDTLRKIRYRGKHLDLSSRESMLEFLRKERRNGSPKQKVNGYIKYLNRLLTFEGLDKIDYIPELRNNSFRKRAFATDQIQTLIVKSKGKTIEDKRNHAMILLALNTGLRRSEICNIKVEDRHNNFLTVNYGKGEKSRDVFLDDNTRKVIMDYSFIRNNNDMPYLFTTKKGKVTPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N348</accession>
    <name>A0A1V0N348_9ARCH</name>
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        <submittedName>
            <fullName evidence="6">Formate hydrogenlyase, subunit 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Respiratory chain complex I subunit 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0584</name>
        <name evidence="7" type="ORF">HLB00_04915</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000167">
        <property type="protein sequence ID" value="NOL60177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841725.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N348"/>
    <dbReference type="STRING" id="74969.FAD_0584"/>
    <dbReference type="GeneID" id="16025791"/>
    <dbReference type="GeneID" id="31676088"/>
    <dbReference type="KEGG" id="fai:FAD_0584"/>
    <dbReference type="OrthoDB" id="15253at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052561">
        <property type="entry name" value="ComplexI_Subunit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43359">
        <property type="entry name" value="FORMATE HYDROGENLYASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43359:SF1">
        <property type="entry name" value="FORMATE HYDROGENLYASE SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="313" mass="35255" checksum="CF3BC4A8EA0AC191" modified="2017-06-07" version="1">MLILIMETLSQYLFVVLFSPLAIGIFEKLKANIESRKGPSIFQPYYDLFKLLKKETIVTENSSRFFLYSPYIAFGIYSLIALIIPVFMTEPIIFTASGDFFAGAILFSLAAFVKIIGTLDSGSNFSSMGASRLMSFNFFGEGTLITVFFAVALISGTNNPYTTNHYLISHPLSNLTLVHIFAIFAFFMVFLYEFGKMPTQSEGNQEMGMIDSGIDYEYSGKALAINKWSSYMKTYLLGSVLINVFLIPWGMFNTFPLFFLNALTMIGKWLLLIVIVLVIDTSLAKLRLFRVIDYLAVAFTFSILFLILTEVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N386</accession>
    <name>A0A1V0N386_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0644</name>
        <name evidence="5" type="ORF">HLB00_07925</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000296">
        <property type="protein sequence ID" value="NOL60753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887704.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N386"/>
    <dbReference type="STRING" id="74969.FAD_0644"/>
    <dbReference type="GeneID" id="16025854"/>
    <dbReference type="KEGG" id="fai:FAD_0644"/>
    <dbReference type="OrthoDB" id="9280at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014651">
        <property type="entry name" value="UCP036983_2CBS_MJ1404"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF29">
        <property type="entry name" value="OS02G0818000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036983">
        <property type="entry name" value="UCP_2CBS_MJ1404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="132"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="207"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="359" mass="40420" checksum="C228FE666AB62639" modified="2017-06-07" version="1">MNVGEIMKKDPITIDSNAKISEAISKMRENDIQQLPVLSEEKYIGMLTYKNILRRGSVRTNSKAYNFSIIAPRINENSNVMEAVKLLVESGLNSIPVFQKEKLVGIVTRLDIIRNLSDIYPDAARTKNYEIMTADVVTVDANDEIEASSQKIRTLDEFEIPVTNNGKLAGILRLKDIINNILMDKQKISYGQYTSGKSKVEIVASSLMDNPINSTEDNTIVDTATLMVKNHLHIIPITGKDSKLTGVVGITDILNSLETGTEEGFYIEISGLEEQDRDLYDITYFMADKFITNISRIIGNNGKLLFNIRKYKTEGKGKYSIRTKLITPKFSMEDDGSGYNYGKCIRDVLNNYETRLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N389</accession>
    <name>A0A1V0N389_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA resolvase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0665</name>
        <name evidence="6" type="ORF">HLB00_07620</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000281">
        <property type="protein sequence ID" value="NOL60696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141770.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N389"/>
    <dbReference type="STRING" id="74969.FAD_0665"/>
    <dbReference type="GeneID" id="84217265"/>
    <dbReference type="KEGG" id="fai:FAD_0665"/>
    <dbReference type="OrthoDB" id="24728at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03768">
        <property type="entry name" value="SR_ResInv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="entry name" value="Resolvase, N-terminal catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050639">
        <property type="entry name" value="SSR_resolvase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30461">
        <property type="entry name" value="DNA-INVERTASE FROM LAMBDOID PROPHAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30461:SF2">
        <property type="entry name" value="SERINE RECOMBINASE PINE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="Resolvase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="4">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="200" mass="23066" checksum="E4E1AE70EBF3AE11" modified="2017-06-07" version="1">MIVGLYARVSTKDKEQNPENQLIRLREYCNARKWNYKEYIDFASGSKKDRPGLKQILDDLDKLDGILVLRLDRFGRSLQNLLECFNIIRSQGKFFEAIDQGLKISEKKDPMNDFMLAILGAAAEFERELISERVKDGMARAMKENKKIGRPRILDKKNISASNIIKLRESGKSIREISQIVGIKRSTVYDIIKSSEKPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3A8</accession>
    <name>A0A1V0N3A8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aminopeptidase</fullName>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FAD_0645</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141744.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3A8"/>
    <dbReference type="STRING" id="74969.FAD_0645"/>
    <dbReference type="GeneID" id="31676149"/>
    <dbReference type="KEGG" id="fai:FAD_0645"/>
    <dbReference type="OrthoDB" id="139771at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 14 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="15">
        <location>
            <begin position="204"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="16">
        <location>
            <begin position="485"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ARD84556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="795" mass="90442" checksum="40BAC8B891E3B546" modified="2017-06-07" version="1">MQIYNYSLDLDINSKNYTYTCHETIKFNGNEEKLILNSVNLKIKRIKVNNSIKNFKEFIKNQEIVVDGIITKDSVAEIDFSGEIPEELQGFYRAHTEEGDMFTTQFESTGARRFFPCIDNPSYKAAFDITVRVDEGLEAISNMPVETKENVDGKTVIKFMQTPVMSTYLLYLGIGKFDERSLEFNGNKKLILAAQKGHLTESNYPLEIGKKAIEFYQDYFGIDYPLPKEHLISVPEFAAGAMENWGAITFREIYLNISSSTGSSVKKAVGEVIAHELAHQWFGDLVTMNWWDDLWLNESFATFMSYKAMNKLEVDYDMFADFLVSETAGALEGDSLVNSHPIEVEVKHPDDISQIFDEISYGKGGSILRMINAFVTDDVFKKGLHLYLENFKYKNASGSDLWEFIAKVSDRPVRKVMESFIQNVGYPIIEAKEEGGKIKLTQYRFLLNGKKQNVQWKIPLTAKYAGEVKSILFDSESMEIDLQGFIKLNDSETGFYRVLYSDSLYENIIKNIAILDNKDIFGLLNDSHAFLMAGKLTLKEYLSRISKFMELNDSLIIREVSNELFSLYLVDPENSEILGANMEYLADKLKILGDKQKSENINVSLARGIVANRFATINRGYAEELSKFAGSLDQVDPDMRLAVLTSYAIVHNDAEKMLDMLSKFKQDEDKVKTIQAMAMLTGDNNFDAVEKAISERKIKAQDSLRYYMLAAANPGAKEYIYNNLENIMEKIQAIFAGSGYSSRVIEMVVPFIGLNHMEEIEGKLAKINIQEISRGIKKGMEYLNINHDLVERLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3K2</accession>
    <name>A0A1V0N3K2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0832</name>
        <name evidence="2" type="ORF">HLB00_05150</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="NOL60221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3K2"/>
    <dbReference type="STRING" id="74969.FAD_0832"/>
    <dbReference type="GeneID" id="84217453"/>
    <dbReference type="KEGG" id="fai:FAD_0832"/>
    <dbReference type="OrthoDB" id="52587at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="53" mass="6197" checksum="E8040D71B926664A" modified="2017-06-07" version="1">MEELLCNIEFEKDEKGFSARLRTDMGGLREYNGMTLEEVLNEVILELQEEFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3L6</accession>
    <name>A0A1V0N3L6_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Signal sequence processing protein Sec11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="282" mass="31771" checksum="03B5EE38E04B4DBC" modified="2017-06-07" version="1">MPLLHMGNAGNKRKYRVLTIIFIAAVIIALVGITVYSGVFPPASVVESYSMEHSAQWQYGIIDEGTVVLVKKVNNINDIVTYVQGRSSNISTYGEYGNVILYHNSALNVVTIHRAIFYLEWNGTSPEIAGYHNQSYIHFYKDNIVLDGIGYAHRNLIVNVSGYAGDSGFITVGDHNLACLSYNSGYYNRTYNAYYASDQNIWGIKPVSLNQIVGKAYGYVPWFGLVKLNILRLEGEWPRQYYTHVPEYSYAGLFLSIAAILTIILFPYGKVYNKVKRKTRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3M6</accession>
    <name>A0A1V0N3M6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein CbiG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0798</name>
        <name evidence="4" type="ORF">HLB00_00290</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000009">
        <property type="protein sequence ID" value="NOL59277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887898.1">
        <property type="nucleotide sequence ID" value="NZ_DAIDCF010000111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3M6"/>
    <dbReference type="STRING" id="74969.FAD_0798"/>
    <dbReference type="GeneID" id="16026018"/>
    <dbReference type="KEGG" id="fai:FAD_0798"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="entry name" value="CobE/GbiG C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052553">
        <property type="entry name" value="CbiG_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37477">
        <property type="entry name" value="COBALT-PRECORRIN-5A HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37477:SF1">
        <property type="entry name" value="COBALT-PRECORRIN-5A HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="CbiG N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="CobE/GbiG C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin synthesis G N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CobE/GbiG C-terminal" evidence="1">
        <location>
            <begin position="211"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="329" mass="35757" checksum="7DF6FCAEF35AC10F" modified="2017-06-07" version="1">MEKYGLAIVAITENGLEISRKISESFPADIFASQRFQPENKVKIFVSLKETIKELFTGYETIIFIMALGAVVRLISPYIKNKFEDPCIIVIDDGGKFVIPVIGGHHGSNELSKGIAGILNASAVITTASDVNGVPSLEMLAKKYSMSIKNTQNLPAVSMDLIDGLPVQVTNNTNIVIPELNNSGSGKRITVSYEIEDNKYGIILIPKVLDVGIGFSTDATYTDMKNAIESVFRKYSLYLEAIRSISTITIKEGNTDLKVLAGDLNCMLNYYPPEKLNENSVTRSAAVYRATGAYSVSNASARISSSGGKELVSKEIINNTTISVFLHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3N9</accession>
    <name>A0A1V0N3N9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">External multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3N9"/>
    <dbReference type="KEGG" id="fai:FAD_0869"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="842" mass="95431" checksum="7C9DAD5DF9789DE7" modified="2017-06-07" version="1">MQIVRYRINYFYLLISFTVLWILINLWYIIFNVYNLNNGGIVDTTTSLQSLLSAFYHQPFVNTVPGGSYFSVHASEILILLLPFFAVWHSFINLYIIQSVLIYSSSIPLFLLAQKKLHNDKASFLMAMVLLLNPYIHDNPFETLTLFMGFIIYSYYFFDAKRYIAFAITFVIALSTMEFNPVIGGFFGLYLILLFLYDKIKISSIKNLIKEPVEQFKTIKSHLSELKNLQSYFSIGIILLIISVAFFYGDKYLILYFSHGSHAITSNIAGSNISSFSAILNDFKTDISSKIDNLMYLNAPFLFLSFLSPLAFLELPWFLTYSISTFSPYWNIGVYYDSYIIPFAAISAILGLYKIHSMLGEGERKKVVNRIAYLALVVTLILLVSNVIAPMVTNPVSPVNSNEYGVDQLASLIPANAKVTTGVNELPIVSSHAYNTWFYGPENNYVLFNITNPPNLNNYGFLAASGSYALYEKGYTGKPELNNLNYTKAEATYYPEERLNINLLNSYVPPGNNNISLHLRYSGNDVHTINSNANKSLFLNDSYAMVYPFKLNNSEQLSNIVLDSHMTYGYYILQSMITTSFHGTQLNKSSIISTDSYGQNQYNMIDENFNYKNVQLNSNKTYYLWLWSSGDPGGLTFPVENTTNSHSYVAKIYNGTGTDSYGYSISKIYSSTEKKLAPRLTFVFNSDKIHKASNIYVSIGGKTTELNVTGNSVYHFSTDGKDIYVNSTVLNGTLGISYTVSASNGREVVNPLLQHPYIILAFIFIVSVFVYPVSSLVNRNTNGLNLKLIEISLIISIIVFYSVFTLYYYRLISIDLIYFKIIGIAIAISFFLFILRFNKNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3P2</accession>
    <name>A0A1V0N3P2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143152.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3P2"/>
    <dbReference type="STRING" id="74969.FAD_0863"/>
    <dbReference type="GeneID" id="31676363"/>
    <dbReference type="KEGG" id="fai:FAD_0863"/>
    <dbReference type="OrthoDB" id="56830at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916:SF3">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="314" mass="36835" checksum="C7013EFB67526E17" modified="2017-06-07" version="1">MENDKLPYISVIITAYNRKEFLLNAIKSVLNQTLSKKYYEIIVIKNFQDDMIDNYILENNIKGIISKDPSLAGKLVEALNVATGDVISFLEDDDLFFENKLEVVYKEFRKDINIVYYHNLCIPINKQGKIINIKRMKTPLDFNMSSISIKKSIIKISKVDTINISTVLDIIMYLYALESNKKIVKGKEKLSYYMVHDSASNILSMNFEEYKNFVIAQVDLNLKNYILFKNLVHSRQGIKYLNWRITHSQIDKYIFGSDEFPSKLLNYVINSFDSLTRRVVLFLSCILIKVYSNSRKYVSYKMWNIHNKWTNEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3U1</accession>
    <name>A0A1V0N3U1_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795622.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3U1"/>
    <dbReference type="STRING" id="74969.FAD_0858"/>
    <dbReference type="GeneID" id="31676358"/>
    <dbReference type="KEGG" id="fai:FAD_0858"/>
    <dbReference type="OrthoDB" id="134456at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34614:SF2">
        <property type="entry name" value="TRANSPOSASE IS4-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="156"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="453" mass="52244" checksum="30ABD39BF25077D2" modified="2017-06-07" version="1">MVFVRKIKKKSGTYLAEVESVWENGKTRQKVIKYLGKEVDGKPVKRVKTSSIKVTAAKKHLDIEIINHIASELGITDISKEILIMVYSQLIERPSINKMEEWLSYTDMLDILKIKNISTSKLYDALDGLNNMDFSKIENKLSSIFSSISDIDGNNAVIIDITDTYFEGNSIDGVPRRGKEEKVKKLMQIALAVTSGNGFPLFHRIYKGNISGKRIFLEMVSLLKENGYSSTIMDRGAYSAKNIESINKLNIKAICGVVKDKYFRNMLLKIDKNRIYRKENRVELKNTHVYCSSMEFMDGKIIIVYNPFLESLRREYYYEHSEDEDIASLLGYSLIYHNTSIPDDEVVRKYYNKDTVERAFRKMKGVISLRPVRVWLMSHVYAHIKICYLSYAILSMLEYKIKSTGISGTDALNILSTGYNVYLKDTESNIEWSENIELSKKQEVIRNLVYKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3W6</accession>
    <name>A0A1V0N3W6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HicB-like antitoxin of toxin-antitoxin system domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142240.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3W6"/>
    <dbReference type="GeneID" id="31676461"/>
    <dbReference type="KEGG" id="fai:FAD_0960"/>
    <dbReference type="OrthoDB" id="133743at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051404">
        <property type="entry name" value="TA_system_antitoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34504">
        <property type="entry name" value="ANTITOXIN HICB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34504:SF2">
        <property type="entry name" value="UPF0150 PROTEIN SSL0259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like antitoxin of toxin-antitoxin system" evidence="1">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="71" mass="7846" checksum="4BB1A475A3EA85F6" modified="2017-06-07" version="1">MKYTVVLEKDENGIYVATVPALPGCISEGKTIEEALINIKDAIQGYIEGLIADKEWIPKDIELIEKVEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Z6</accession>
    <name>A0A1V0N3Z6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142289.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Z6"/>
    <dbReference type="GeneID" id="31676486"/>
    <dbReference type="KEGG" id="fai:FAD_0987"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="222" mass="25401" checksum="1D1EA6A614A594D0" modified="2017-06-07" version="1">MYDPERIKGNVKEKREKNKKIAVKLFISAILIYIVMFSVEAIISKNLIINYALILILIGFSIVIITSVKLINKINIKLNKKIENRSNIKLIEAFVLLSIIISFSVYYLLSKNNITLYILVALLLICSIIISRMMNIFYKLLNSGIISINTNFNKNIKYSTLVDVGGILLILAIADIIILLISEMSRFLNLFSISIITIFSAIIVLLAFYIYKSYNYKLFKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N441</accession>
    <name>A0A1V0N441_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VapB-type antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142258.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N441"/>
    <dbReference type="STRING" id="74969.FAD_0967"/>
    <dbReference type="GeneID" id="31676466"/>
    <dbReference type="KEGG" id="fai:FAD_0967"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045944">
        <property type="entry name" value="DUF6364"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19891">
        <property type="entry name" value="DUF6364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="92" mass="10589" checksum="7B5E66E7138C1665" modified="2017-06-07" version="1">MKRKLTLSIDEEVINKAKSALALKNITLSAFVENDLKLLLSEDELDKSFNSIGIKYNYTSPDAIVEKRKKMKIVDTQNILDEIRDEMDERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N446</accession>
    <name>A0A1V0N446_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142314.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N446"/>
    <dbReference type="STRING" id="74969.FAD_1000"/>
    <dbReference type="GeneID" id="31676499"/>
    <dbReference type="KEGG" id="fai:FAD_1000"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052528">
        <property type="entry name" value="Sugar_transport-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23526">
        <property type="entry name" value="INTEGRAL MEMBRANE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23526:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="418" mass="46287" checksum="91667DE1FDED34AA" modified="2017-06-07" version="1">MDNKKLIAFRSLIIAAGATVAASFVGVYGVMIGATAAEMGWLQSSSNSLSNLGQILWGRISDRVGKRKPFLVSGSVILAVLWFLLPYSRTPVNLIVLYSLISIFSAMITVNWYSFIADNIISERGRFLTLINDIASAGTIVSLIAMVFILAKYPDDVVIPFSTAAASYVISAVTVFKFKESRSKSVMTRNLYKTLKNLKNNNAFYKYFRATNIQSFFWSMAWPMFPITIVSIMHFSLEIVAVLTISSTLTMLLTQYIIGKFIDKVNRVPIIFLNRIMLSGIPLMYAFFNILPLFILLEIYSGFIGSIQNTVTTSYTLDIVPQNNKAEYISILNGFNGMVYFFGALTGGYVLTLFLSVEPLKIALLLSYLIVFAGRFLSSFLFRGLIEENSGGRNNSVLSILFKPKGAGSPSGAVIHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N476</accession>
    <name>A0A1V0N476_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
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            <taxon>Thermoplasmatales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N476"/>
    <dbReference type="STRING" id="74969.FAD_1024"/>
    <dbReference type="GeneID" id="31676523"/>
    <dbReference type="KEGG" id="fai:FAD_1024"/>
    <dbReference type="OrthoDB" id="7236at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="342" mass="39047" checksum="0DFE5AEAB6E8A693" modified="2017-06-07" version="1">MKYVNVGNSGLKVSTVAIGTWHLPGSGQFVNKVESVDEEEFKKIFKKAYDLGINFYDTADIYHGRVEHNEDCIECTGNSERVLGNILKDYDRESLVISTKVAGPMNYYVNSSGLSRKHILHGIKSSLERLKTDYVDLYQFHWSDNDTPLIETLKAMSHTVDLDLSRYIGMSNVNACDIPEFMNLSEKYNLNNFITMQEAYNILDRKIENDKILYAQRYNLGLLAYIPLDQGILAGKYLNNYGKGSRITYYSGLQNEIDRTLNTVKKLKEFADENDITLSQLAIAWLLNRGRELNIKIIPLLGITNIKYLDDNINALNVNLKTEDMKYINELSSAYTNDNMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N484</accession>
    <name>A0A1V0N484_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N484"/>
    <dbReference type="STRING" id="74969.FAD_1040"/>
    <dbReference type="GeneID" id="31676539"/>
    <dbReference type="KEGG" id="fai:FAD_1040"/>
    <dbReference type="OrthoDB" id="371889at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052714">
        <property type="entry name" value="MFS_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23531">
        <property type="entry name" value="QUINOLENE RESISTANCE PROTEIN NORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23531:SF1">
        <property type="entry name" value="QUINOLENE RESISTANCE PROTEIN NORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="12"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="405" mass="45009" checksum="8A607BCFB5207E5B" modified="2017-06-07" version="1">MNNTNNKLLLINLIMLLSVAFTMRTSTNMLMTVVPVFTKYVINADVFFVGLTATLYGIGAMVANVLINGRINIEKTPRTIALLLLIMTVGIFFYLLSNNIYEVLILSTVTGLSMGVVQPLLMTVTNVIAPPGKRDKYIAAYTASLSLSLIFGVVMEGLITSSINVRYAFLIFLFISLLSTVLMFTLSTRIKMNMKRKNRLTFKEILGKASHSLKQGKVLFALFGNIAYAFPFILLITYGSLMGKEYNGINPDIFFYLLALFYIVSFLTRLVLSVKNVKNHEILMYASFAATIIGYLLLGIDAGIIMFIGSLLILGFPHGSIYPTASYYIASSVELEDLNVVYSVFILIMDVIIFLIPFVFGIISTIYSIRIAIYLTAVPMGLLLLTSVFFNIKDNRAIKNTPVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N486</accession>
    <name>A0A1V0N486_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Drug:H+ antiporter-1 family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N486"/>
    <dbReference type="KEGG" id="fai:FAD_1033"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517:SF14">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="356" mass="38790" checksum="3FE5A48220B32F2D" modified="2017-06-07" version="1">MHDILKISLLYVGIIFTAGGFIAALVNIYGGAISDRVGHKETMIFSFSISVVIYAVLSFVPGVSLSAFLYPVAFIMFMIANAIMSPASNALISRSSDIQLKGFSILRVGNNIGWGFGPAIGGFIESFGGYHLLFVFGLIMGIISLGISLFLRNVKYDEKIGKVPLTTSNTWLIQLSLIALLLFVVQSQETVTLTNYATIFRSIKIYQLGIVYLTNGIFVIVLQGFIYKIIRKIGNFASFAIGSFIYSFGFFSYAFDTGIIGMIISTIVLTIGEDFAFPVGYSMVSAVSKPENIGKNMGIYNAFLSVGRAIGPTLGGAAFTIFTIPSEIWLFTTFTGFVACIIFIVKFRNVESLKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4B4</accession>
    <name>A0A1V0N4B4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1099</name>
        <name evidence="3" type="ORF">HLB00_00900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000025">
        <property type="protein sequence ID" value="NOL59397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886203.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4B4"/>
    <dbReference type="STRING" id="74969.FAD_1099"/>
    <dbReference type="GeneID" id="16024328"/>
    <dbReference type="KEGG" id="fai:FAD_1099"/>
    <dbReference type="OrthoDB" id="18264at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07391">
        <property type="entry name" value="MPP_PF1019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004376">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00024">
        <property type="entry name" value="SbcD_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39323">
        <property type="entry name" value="BLR1149 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39323:SF1">
        <property type="entry name" value="BLR1149 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="242" mass="28369" checksum="A90081854A54925F" modified="2017-06-07" version="1">MKDIQIVKDVFISDLYCVYLQDISAVVISDLHLGFEEEMNLHGIFLPKLQRSHVEKMVDQIMDRYSPSKIIINGDFKQEFSRNLPQEWDDVNHFIDRYRKESELIFVRGNHDNYLMTILKSNGLEIYDYYETDNYYIYHGDRDMSYRKLTILGHEHPSVVLRDEIGSVFKLPAFVYNNEQKMLITPAMSFFSSGTDVSESLLNNEHFTPVLKNVSKKFRAYGITEDFGLLDFGYVTDLAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4D3</accession>
    <name>A0A1V0N4D3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142499.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4D3"/>
    <dbReference type="STRING" id="74969.FAD_1126"/>
    <dbReference type="GeneID" id="31676623"/>
    <dbReference type="KEGG" id="fai:FAD_1126"/>
    <dbReference type="OrthoDB" id="9141at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="122" mass="14014" checksum="18BCBE1F3292F83F" modified="2017-06-07" version="1">MGSFNQILDENATCRDMFEYFFDLSPADVAVLYSLDNETGATLDEVAVKVHKDRTTVFRSLQRLVGTGIVTKKKNILEKGGYYYSYSRISKAKIIELINNREGEFHSVLQCLLRDMESEFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4D7</accession>
    <name>A0A1V0N4D7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142439.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4D7"/>
    <dbReference type="STRING" id="74969.FAD_1068"/>
    <dbReference type="GeneID" id="84217668"/>
    <dbReference type="KEGG" id="fai:FAD_1068"/>
    <dbReference type="OrthoDB" id="40383at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38445:SF7">
        <property type="entry name" value="GNTR-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38445">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REPRESSOR YTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="127" mass="14375" checksum="EA58F9D298D92EAB" modified="2017-06-07" version="1">MVKALEIVIDRNSEQPLYLQIYNQITYNISTKKLNKGDILPSSRTLAEVLNINFHTVNQAYQKLRTNGIIVLGKSKKYVIADGNNSEKGTKLIEKEKDMVNEALAMGYTENDIIESVKRIISSIRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4E5</accession>
    <name>A0A1V0N4E5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886206.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4E5"/>
    <dbReference type="STRING" id="74969.FAD_1102"/>
    <dbReference type="GeneID" id="16024331"/>
    <dbReference type="KEGG" id="fai:FAD_1102"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="19"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="481" mass="52045" checksum="89B5FF63F3F3F184" modified="2017-06-07" version="1">MVITHTKLKRDSVGLLQGIFQSLGQVAPAADIAILLVASFSISGAQTVMSVIIGWIIYALWMITPYEFSKIKSNSGSYYAYAAGATEKGRLGPITALSFMYYDITGAAFGILGLSSFIFLMAPEVTSIPYLWILFAGIFTAFIIIVTYLGIRPSLNYTAITGLLEIMFLLIGSIIIIIRVGGHNSVVPFEITGPYSVGFSSIMFASVFSILDFTGSGVVTTISEEISKPKKNIGKSIIFAMVLTAVALIPAAYALTVGWGVSSIGSFASHSDAGLTVFSRYLGPIGLVLLIVFTINSYFSNGVSKATAVSRWWYSAARDHVVFPETIGKINEKHHSPANAAIIWAGLSFVLDVIMGLIFGPLSAAFVLEAGTGISIVIVHMIANTSLTLYTRRVNRFNLLKHGILPSLATIIGLVVIYFTMSDIFKKFLVTPSAVNDAYFVSFVVTILWILLGGIVVTLYYRIKKPEILKDAGEFNMKSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4H0</accession>
    <name>A0A1V0N4H0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt-precorrin-3B C(17)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142487.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4H0"/>
    <dbReference type="STRING" id="74969.FAD_1120"/>
    <dbReference type="GeneID" id="31676617"/>
    <dbReference type="KEGG" id="fai:FAD_1120"/>
    <dbReference type="OrthoDB" id="35891at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051810">
        <property type="entry name" value="Precorrin_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47036">
        <property type="entry name" value="COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47036:SF1">
        <property type="entry name" value="COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="247" mass="27161" checksum="B232FD4931CCB738" modified="2017-06-07" version="1">MPKLYLIGIGPGSNGEITGDAIESLKNSDIIMGYSKYIELIEEFVSDKEIESGPVTDEIGRANNAIKYVMSGKTVSIVSSGDSAIYGMAGIVFEIIASHNYRIDLQIIPGITALSSAGSLLGVPFMNDFCSISLSNKLTPEDIILKRIHAAGAGDFVTAFYNPVSLKRTELIKKAREIMLEYRNKDTPVGLVTNAYRKEQKVEISTLGNFLQSDIDMFTLIVIGNSSTYVYGKYMITPRNYHNKYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4H6</accession>
    <name>A0A1V0N4H6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein alpha and beta-subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1162</name>
        <name evidence="3" type="ORF">HLB00_05720</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000191">
        <property type="protein sequence ID" value="NOL60331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886266.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4H6"/>
    <dbReference type="STRING" id="74969.FAD_1162"/>
    <dbReference type="GeneID" id="16024391"/>
    <dbReference type="KEGG" id="fai:FAD_1162"/>
    <dbReference type="OrthoDB" id="307696at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF17">
        <property type="entry name" value="PROTEIN FIXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="1">
        <location>
            <begin position="288"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="608" mass="66629" checksum="6377A312709E5A4E" modified="2017-06-07" version="1">MKGINIVVSVKQVPDADDLRIDPVTNNLVREGVPAIINPPDLHAIEEALRLKEKYGGTVSIVSMGPPKGDITLRESVAMGADNVYLVTDAAMVGSDTWATSYTISRSIEKIGKPDIILFGRRALDGETQQVGPQTAMWLGIPEVAYTDKIIDIDMETKIARLQRTTEFDTETVEVKMPFVATITENSNSPREATLEGMIKSITFPVTRYSKTDINADPKMIGLAASPTKVIRVRPPPKMRNPEIIKNEDLNKTVDFLISKIKGSLTGMKAMEEAYQKPEPVTKVEDSIWVYIDHFDGELNKTSLEILGAARRVADLMSTKLGAIIIGTGDENLIDEAFKYGADEAYYCETDNAKRYDNDIYTQALGMMINKYKPNSLFFPGTYNSRELAATTAIKVNTGLIADCIIFDVDEKGQLQATRPDFGGKETSTIICPNNKPVMVTTRAGVFSALPERDFKGKVIKDKLEKPVSRFKITDYKNIEKTNALAAAQVVVGVGRGIVNKDNIKLAEDLAKKIGGIVGVSKPLADSDWYPKDRQVGQTGTTIKPNLYIAMGISGAIQHLVGIQGSKRIIAINSDPDAQIFENCDYGVVGDIFQIVPELIKKIGDLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4K1</accession>
    <name>A0A1V0N4K1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase (Flavoprotein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142549.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4K1"/>
    <dbReference type="STRING" id="74969.FAD_1161"/>
    <dbReference type="GeneID" id="31676659"/>
    <dbReference type="KEGG" id="fai:FAD_1161"/>
    <dbReference type="OrthoDB" id="7950at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-QUINONE OXIDOREDUCTASE YDIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624:SF2">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-QUINONE OXIDOREDUCTASE YDIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="397" mass="43171" checksum="5C25D0DC4850E6DE" modified="2017-06-07" version="1">MLEYDIVIVGAGPAGSAAALKAASEGKKVLVIERGPEPGSKNVSGAEVRKDYITSVFGEGMPYERTVDTMKLSLYEKDKPVNIDFHPDGLVTTGRLKLDKWLSSVSEQAGATIIPKTTALKLNWENGIAKSLTTDRGDVAAKSFVLAEGVNALVSMNSGINVDWTPSNSVQAVKMVYSIKKGDLNNIFGFPDDDTGMSWRMIMSDPLVAGFMYTYKDSLAVGIGSPIKELVDRKIRPEALLDKFLETTGIAEKVKGYSLREYSAKVIPEGGFPETNVAKGNVYLCGDAIGLVDPLTFDGITPAIASGTLAGEAAVMNYDKEVYRYNLMKHPEISKIAKERKLESDFMTSNKAGEYINMVSSLLEGWAAGDLIGIRNTMVGNYRNIIPDLMSFVMRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4K4</accession>
    <name>A0A1V0N4K4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142545.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4K4"/>
    <dbReference type="STRING" id="74969.FAD_1158"/>
    <dbReference type="GeneID" id="31676656"/>
    <dbReference type="KEGG" id="fai:FAD_1158"/>
    <dbReference type="OrthoDB" id="8791at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="530" mass="59442" checksum="330FE4801446D29A" modified="2017-06-07" version="1">MEKYVIVDRYFDGYKWENNSTIFKVKNGIIAEKYTANKQDMENIMESGNEVLDLRGKFVTPGLIDSHDHFMLTSLKLKYQVDFSGVRSFEDFRRVLEENRNKIVHGWFQGYGINEYNMKEKRLPDIKIIDEIMGNTPVFITQMTEHYGICNSRSLEIAGIDRNTADPANGKLGRNSDGNPDGVLYEANAMDMVKSRIPEYTLDDYIEAIISGSEMYRKAGLSTVKDIGGTGNDVNEETRICALNRISKEGNHKIRIAVALPVYSLKDVSRKIELASILEENQHIMFAGFKMFLDGSILSRTAWMKHSYVGSKGNMGIPLWDIKNFREGLKQLSATGHHISIHTIGDRAIETALDSIEKLKSSGIASAYALVHCYKLEEKTIEKIKKLDVGVETQLAFVYFIGDSLSDNIGLDQSKCLFPAKTMVEKGIRVSNGSDSPVTPFDPLYGIYSSVFRKTLTGKNSSVYSNNESLTIEETVKTYTSESAAVIGWNETGSLETGKFSDFTVWDPDPATAGKNIEDYLHINLKSITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4L2</accession>
    <name>A0A1V0N4L2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940554.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4L2"/>
    <dbReference type="GeneID" id="31676651"/>
    <dbReference type="KEGG" id="fai:FAD_1153"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="129" mass="15207" checksum="FA8D6EDB794C1E4A" modified="2017-06-07" version="1">MPSRSMDWLKQAKRDLEEAEGSLNNEKYEWACFASQQSAEKAVIALYHSINKEIWNQSVSRMLSQLTEFNIDNNIIARAMELDRVYIGSRYPDYYSEGSPFEYYSIEDAKRCLNYAKEIFEFCSKNIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4L6</accession>
    <name>A0A1V0N4L6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1169</name>
        <name evidence="3" type="ORF">HLB00_05375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000179">
        <property type="protein sequence ID" value="NOL60265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886272.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4L6"/>
    <dbReference type="STRING" id="74969.FAD_1169"/>
    <dbReference type="GeneID" id="16024397"/>
    <dbReference type="KEGG" id="fai:FAD_1169"/>
    <dbReference type="OrthoDB" id="304253at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="203" mass="23061" checksum="87DECB85FF82F487" modified="2017-06-07" version="1">MLVYMVRHGETYNNASAVFPLDDTELNENGLEQARETGKYLEQLYFDAVYSSPVLRVKQTLENMGIDRYITDNRLRDIGTGKLTGMKITEIESKDPAWYSTFQDGVENRYGVEKFSDLKKRVKEFIGSISGNGFKKVLIATHLEPIRGMYSLSTGVEGLPLTSLEISNCSISIFSVEGFDIELKGFNWLPLNNYPDRKNKSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4L8</accession>
    <name>A0A1V0N4L8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">ABC-2-type family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1177</name>
        <name evidence="3" type="ORF">HLB00_05415</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000179">
        <property type="protein sequence ID" value="NOL60272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886279.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4L8"/>
    <dbReference type="STRING" id="74969.FAD_1177"/>
    <dbReference type="GeneID" id="16024405"/>
    <dbReference type="KEGG" id="fai:FAD_1177"/>
    <dbReference type="OrthoDB" id="57122at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43471">
        <property type="entry name" value="ABC TRANSPORTER PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="273" mass="31470" checksum="83F0ED7D85BFE388" modified="2017-06-07" version="1">MSKTSTIYLQYIKNYYRSRSFFLMLFLILLIGSMMSYFSFKYVNDLPSFLGGTVFPASMKVNVFYYLWTLVLLYIPVFASVFFGSPAISSEIENKTAYFIFPLPINRYKLFFGKYFAAFTVTMFIVGIYLIFEVFTLSYLLGAIPATYFSYSFIMLVLFILSIMSVTFLISAIFNKNTYAYITVFVIYYIFFEAGSFIIELLYKYTPVYFLNDAASIIERVYININPGNAFVSHIDINPASFSEIMLSALIMVIYAVIALVIGMLLFDKKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4P1</accession>
    <name>A0A1V0N4P1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrI</name>
        <name evidence="10" type="ORF">FAD_1185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Contains catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142563.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4P1"/>
    <dbReference type="STRING" id="74969.FAD_1185"/>
    <dbReference type="GeneID" id="84217780"/>
    <dbReference type="KEGG" id="fai:FAD_1185"/>
    <dbReference type="OrthoDB" id="7000at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.20">
        <property type="entry name" value="Aspartate carbamoyltransferase regulatory subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="entry name" value="Aspartate carbamoyltransferase regulatory subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00002">
        <property type="entry name" value="Asp_carb_tr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00240">
        <property type="entry name" value="ATCase_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805:SF1">
        <property type="entry name" value="ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aspartate carbamoyltransferase regulatory subunit N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate carbamoyltransferase regulatory subunit C-terminal" evidence="9">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="151" mass="16673" checksum="2D867E04A5F98A83" modified="2017-06-07" version="1">MDKTLKISKIKDGTVIDHIAAGKALKVLAILGIDESNSISIGIRVTSGKLAYKDVIKIENKFLEKLELDKIALIANEATISIIKNYEIIEKFKLDMPQVFKGIVKCANQNCITNAGEPVKSEFMTVNADPLTIKCVYCKKEMSGEEIINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4P7</accession>
    <name>A0A1V0N4P7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1203</name>
        <name evidence="2" type="ORF">HLB00_06230</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000215">
        <property type="protein sequence ID" value="NOL60429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142589.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4P7"/>
    <dbReference type="STRING" id="74969.FAD_1203"/>
    <dbReference type="GeneID" id="84217798"/>
    <dbReference type="KEGG" id="fai:FAD_1203"/>
    <dbReference type="OrthoDB" id="10940at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF29">
        <property type="entry name" value="GAMMA CARBONIC ANHYDRASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="174" mass="19076" checksum="C4C764C1B290D1FE" modified="2017-06-07" version="1">MIYEFEGQVPEISRKAYVFDNATVIGNVHIGDYVWIGPGAVLRGDYGEISIGAYSAIEDNCVIHARPGEKTTIGEHVTIGHLSVIHTGTIDDYAVIGMNSTVSDFATVGKWAAIGEGAVVKSKSKIPDRSIAVGVPAKVVGEVSEEYMKTWEKYKENYNSFCKRYLENLKVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Q9</accession>
    <name>A0A1V0N4Q9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Q9"/>
    <dbReference type="STRING" id="74969.FAD_1213"/>
    <dbReference type="KEGG" id="fai:FAD_1213"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="91" mass="11125" checksum="095BBD6692D0583E" modified="2017-06-07" version="1">MLMDDIEHFLDGFIYFSIKNIQMKSYILKGFYDISINKTVYLKINMLSIKNENLHIYRVSSQIFSISMDNIKDFWIKWDYRKPDFRIQARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4V1</accession>
    <name>A0A1V0N4V1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1015 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1302</name>
        <name evidence="4" type="ORF">HLB00_02400</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000073">
        <property type="protein sequence ID" value="NOL59685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886406.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4V1"/>
    <dbReference type="STRING" id="74969.FAD_1302"/>
    <dbReference type="GeneID" id="32192124"/>
    <dbReference type="KEGG" id="fai:FAD_1302"/>
    <dbReference type="OrthoDB" id="146312at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16387">
        <property type="entry name" value="ParB_N_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1760.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023098">
        <property type="entry name" value="SerK/SbnI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454:SF1">
        <property type="entry name" value="DUF1015 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="LMO2823 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="386" mass="44418" checksum="D9F024F50954F333" modified="2017-06-07" version="1">MNIKEFKPYIFSGNIVDSVSPPFDTITIEQEKKLRAAKYNITALSLPEYGNSSLTPEKLIKKWIGDNVIYPYGKDIIIILKQVFYINKEIITRYGIISLAEIDSSLKAHESTFEKQVLERKNVMISLNGEPEPIFIVVPDNGFDKMVRRFASNLEEKFKFEEPSGVENYVYFLEDQEKIEKLKDSIKNDQGIVADGHHRTQAIKDLKKETGDSFWNYAMAYITSIYDNGLMIGGVDRLVYRTNFEENIPKIENLFDVTVERTIVEDNNIRVYSRGLFYKLVPKKYAIDQVMDSKYEVSTEIVNKILFGEVLGINKSNMQTKIGYIYNTTDAINAVDMHECDFAIIIPPWQKDVFLKMALDGVIFPQKSTYFYPKIPSGIAIYLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4V7</accession>
    <name>A0A1V0N4V7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1267</name>
        <name evidence="3" type="ORF">HLB00_03200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000102">
        <property type="protein sequence ID" value="NOL59840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841362.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4V7"/>
    <dbReference type="STRING" id="74969.FAD_1267"/>
    <dbReference type="GeneID" id="16024495"/>
    <dbReference type="KEGG" id="fai:FAD_1267"/>
    <dbReference type="OrthoDB" id="57137at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="85" mass="9381" checksum="FBE7C65C72E262B4" modified="2017-06-07" version="1">MLIDYAIASINAMMGRIDDIVISVSAVLITLLWIPIALNFFSTDENKKIMARERLKNAAIGTVIFIMAISGILFTVFNYVVTGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4X8</accession>
    <name>A0A1V0N4X8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Drug:H+ antiporter-2 family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142775.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4X8"/>
    <dbReference type="STRING" id="74969.FAD_1296"/>
    <dbReference type="GeneID" id="31676794"/>
    <dbReference type="KEGG" id="fai:FAD_1296"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17321">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000503">
        <property type="entry name" value="Drug resistance transporter, EmrB/QacA subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000021">
        <property type="entry name" value="Drug resistance transporter, EmrB/QacA subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="12"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="482" mass="51726" checksum="B781C539241D020D" modified="2017-06-07" version="1">MDKVEDKKRTYILVSVLIGMLMSAIDTTIVILALPTLTVDLHAPFINTIWVILVYLLVLATLTTQMGKLGDIFGRGRIFNVGFIIFIIGSAMSGASPTIDFLIFSRIIQGFGAVLLQANSNAIIADYFPARERGRAFGITSMGWSIGGVLGIVLGGIITTFIGWRYIFYINVPIGLIGFYIASKYIKDNKKSSTKIDYTGTALIVAMLGLISYGAIEVASVGANYFNLALVIIGLIIIIPFAILEKRSKSPVIDTRVFQNRKLSMSLAAATLQAIGFLSVIFILIMYLQGVRGLTPFYASLVLVPGYLLSSFLSPKMGKLSDRIAPGMLAGTGILLMAAGIVVYLFLGVSTPIYVVIAGSIITGFGGSMFWPSNTSSVMSNSPKQLYGSSSGLLRTLTNIGTLMSYVIAITVAASTVPRYVTFEVFLGVDKLQGGLSSKFIVGLHYALLVSMIVLVMGALMSYMTVARKKKAASVETNSGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Y0</accession>
    <name>A0A1V0N4Y0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1288</name>
        <name evidence="8" type="ORF">HLB00_03305</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000103">
        <property type="protein sequence ID" value="NOL59861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142762.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Y0"/>
    <dbReference type="STRING" id="74969.FAD_1288"/>
    <dbReference type="GeneID" id="84217883"/>
    <dbReference type="KEGG" id="fai:FAD_1288"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF7">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="454" mass="48771" checksum="C9CA0B1E0F20ED9F" modified="2017-06-07" version="1">METYGLKRILGLRSAIIINLGAIIGAGIFVIIGIAAGKAGPAIIISIFVSAIIAIFTGLSFSEIAQHISKEGGVYEYAKESFAPSAGFIGGTMWTFSNMIAISAVSLSTGSYINSLFHLHIDLIVFGIPIIIMFAILNMLGIKNSAKTLSILVGINIAILIIFVVSGLFYFKLTDFSNFDPHGFTGIMEGSALIFFAFTGFSRITTIGDEVKNPEKNIPKAIIISIIISSALYSIVAVVAIGLIPSSNLASASAPLSAAIAVLDNPYILIIVAIGGITATAGVVLTGILGTSRVLYAMGRDREIPGTFGRIDKFGTPLYSILLSMAISLLFVYFVGFATIIEASNVSVLIAYSIIDFSAIMLWRKVKRENPKHMREQKYFFIIPLIGMATIFITISYLGLHAIEISLAVLALVSGIYGIKHVMESGGYIRKAKQIIPGYSKVRLFGRSRQQIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Y5</accession>
    <name>A0A1V0N4Y5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142781.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Y5"/>
    <dbReference type="STRING" id="74969.FAD_1299"/>
    <dbReference type="GeneID" id="31676797"/>
    <dbReference type="KEGG" id="fai:FAD_1299"/>
    <dbReference type="OrthoDB" id="10536at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="15"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="4">
        <location>
            <begin position="186"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="405" mass="45419" checksum="9DEBD7A1719C1146" modified="2017-06-07" version="1">MNYIESHFENMLSGKKIIIASSASISIYRIPDLIRDLKREGASVVSAMSQQAVSMIGQTIMEWATGNPVVTQITGNIEHISMFDENTILLVAPASYNTIGKMANGISDSIPSLFFSYALGHGNKIVVVPAMHRDMFENPVNKENIEKLKKLGVLVVDPEFDETKAKIADNDRIIDYVCRSIYGNALNGKNVLIISGRSELAIDPVRVITNRSSGYTGYWLARNAFRLGASIITYVGNSEYNIPGYATYMEKYNLRDIIVEINTYISVNKYDYIIMPMALMDFDMKESKTKLDSGADQNLVLTPRPKVRDRIRQMALGAVLVLFNLESEKSYNSKKFEKSDPDMVVLNSFDKKPFGDTKNDYTIISKGRKEEIENADKATISLEIYNRIKDMTRDSGEPGMNSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Z0</accession>
    <name>A0A1V0N4Z0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Z0"/>
    <dbReference type="STRING" id="74969.FAD_1311"/>
    <dbReference type="KEGG" id="fai:FAD_1311"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="73" mass="8424" checksum="CC7B0FDF387579B9" modified="2017-06-07" version="1">MEDLKSTIVEQITKMENIPAENVEILDVFYYSGLKKWAVSVAFNVNGKHYVASMDILENGLVARYQQREKNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Z1</accession>
    <name>A0A1V0N4Z1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF309 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1297</name>
        <name evidence="2" type="ORF">HLB00_03535</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000113">
        <property type="protein sequence ID" value="NOL59905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142777.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Z1"/>
    <dbReference type="STRING" id="74969.FAD_1297"/>
    <dbReference type="GeneID" id="31676795"/>
    <dbReference type="KEGG" id="fai:FAD_1297"/>
    <dbReference type="OrthoDB" id="57575at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.10">
        <property type="entry name" value="TTHA0068-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="TTHA0068-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="197" mass="23267" checksum="61832CADF7A1F08F" modified="2017-06-07" version="1">MKALIISSEGIGNMQEYWNPGRYINIYNMRMDRLKRDSLFMKLKENDPFVYDLRVENGMVELSYFLNINKYTTNAMGKYFFTSDINYLQEIRSFDFAVYLMEGERYWEAHEVLENNWKNSSGIEKLTYQYIILLCAAGVHMQRGHDSVCRNIILRANKMKILNTMGKLDISGMRNEKSKNPYAELSDLVFHYSLQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Z6</accession>
    <name>A0A1V0N4Z6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142832.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Z6"/>
    <dbReference type="STRING" id="74969.FAD_1347"/>
    <dbReference type="GeneID" id="84217959"/>
    <dbReference type="KEGG" id="fai:FAD_1347"/>
    <dbReference type="OrthoDB" id="34275at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000462">
        <property type="entry name" value="Glyoxylate reductase (NADP+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF283">
        <property type="entry name" value="GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="4"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="106"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="311" mass="34664" checksum="1DD239D2669F091D" modified="2017-06-07" version="1">MYKILVTRNIPGNYIEKIENMEIEVFSGKGSMREWLLSNIGSADGILITLNEKIDKELIDHGKKLKVISTYSVGYDHIDVEYAKSKGIIVTNTPEVLTDATADLIFGLMIAAARNIVSGNNLIHKNEWKAGWNPTFMLGSEIHGKTLGIVGMGRIGKAIARRASGFDMKIIYYSRHRHDVDADFVSIDELLQKSDFVIIALDLNADTFHFMDYRKISKMKKTAFLINGTRGKIVNEKDLVRALDEKIIGGAALDVFEDEPVDNTNPLLSFNNVVVTPHIGSATYETRDKMAETAVTNLVNVLNGKDPLYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N535</accession>
    <name>A0A1V0N535_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ammonia permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1351</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142840.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N535"/>
    <dbReference type="STRING" id="74969.FAD_1351"/>
    <dbReference type="GeneID" id="31676843"/>
    <dbReference type="KEGG" id="fai:FAD_1351"/>
    <dbReference type="OrthoDB" id="10960at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="18"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="433" mass="46895" checksum="A8B6AD0020919A9E" modified="2017-06-07" version="1">MFDFIDYLSISNILINNLWIVIAAIFIFAMTIAVGFLEVGELGKKFKNSMLKTIVITGTAMFVMSIIGFNTAFAPTLYGIIGNPFYKDGFMLGGFSPGVIFNTWWSMGTSYFNTGLTTGSYFFFETACAAVTLALVGVIVLNKVKFGAFFAFSIVYFIFIWNLPAAWIWNPSGWLYQMGMRDFAGGIVVHGAAAIAGLAIIYEIWMEERKKGLKTSLKVNIKPDYQWLAVGILILWIGWFGFNPGSVLAFNDDVLVVVIATFIASGAGMVSTMLFSRMFDRETPIIIVAVNGILMGLIIVTPLAGFVSPASALILGLIGGPLYVGAEKLFAKVKWFSDPVGLFPAHGVGGIFGVLMIGLFTQHAFAAASGNAILPNGLLFDGGFAALRQLGIEAFGVFVVVITVFAISFLAIFIIAKLSHGILNEDAYKNLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N563</accession>
    <name>A0A1V0N563_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N563"/>
    <dbReference type="KEGG" id="fai:FAD_1386"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="67" mass="7794" checksum="D82C7CF22B184B32" modified="2017-06-07" version="1">MKQIGGIYLYVDNTKSSNLLLLQFSSIIKEYFVVFSKSGFNCNMKDIPKINNIILFDLKKMQEIIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5B2</accession>
    <name>A0A1V0N5B2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="8">FGAM synthase</shortName>
            <ecNumber evidence="8">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="8">FGAR amidotransferase II</shortName>
            <shortName evidence="8">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purL</name>
        <name evidence="12" type="ORF">FAD_1431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142897.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5B2"/>
    <dbReference type="STRING" id="74969.FAD_1431"/>
    <dbReference type="GeneID" id="31676923"/>
    <dbReference type="KEGG" id="fai:FAD_1431"/>
    <dbReference type="OrthoDB" id="8251at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002290">
        <property type="entry name" value="PRK01213.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="11">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like N-terminal" evidence="9">
        <location>
            <begin position="83"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="10">
        <location>
            <begin position="214"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like N-terminal" evidence="9">
        <location>
            <begin position="456"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="10">
        <location>
            <begin position="587"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="749" mass="82666" checksum="6CB15D194F577F19" modified="2017-06-07" version="1">MYDIIKSSNENLGKIAGELGLTYDEIVMLRNYFTGLGRNPTDIEIQAIAQGWSEHSCYKSSKLYLKKYFSGLKSDYTILTMEDDAGVISFDDNYAYVVKMESHNHPSAVEPYGGAATGVGGIIRDVLCMGAQPVALVDSLYFGDPDNMDGNLTERFILNRVVAGIRDYGNRVGIPTVAGSTHFNKVYNGMPLVNAGCIGIVRKDHVVRSRVSVEGDLLIVCGGRTGKDGIHGVNFASKVLDKGSEENRNAVQLGNPIIKEPLIHAILEANEESIIDGMKDLGGGGLSSAVSEMLFAGGMSGIINLDKVLLKDSHMEPWEIWVSESQERMFLAIKPSNLQKISRIFEKWGIEYSIIGETVKNENLVINFNGEKILDMKLSFLTGGPMYARSYKKPELEEKTVLDREPENYRDFIIKFLSNPNICSRFNIVRQYDFTVRGNTIVKPFAGFPNHETHSDAPIIKPVEESYQGLCLTSGSIPEMVGIEPYKGTMHVLSEGYRNILSSGGKPHSIVDALNFGNPENPQTMYRFIESIHAISDFCKATGLPLVSGNVSFYNETDIEILPTPNMLLIGKIEDVRKAKTVEAKTPGNPIYLAGSIINDLAGSQYSSIMGTVHTKLPDLDIDELVNINKDLSDSMDYIESMHDISTGGLLMAILEMSFGGPYGIDADISDIHGRTNEKLFSELGTGILIEVRKSDEKDFLEAFSRSNIRKIGTVIDGEVKISENGRYILSAKSEKLRSIWEKGLDKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5E2</accession>
    <name>A0A1V0N5E2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 14">Ribonuclease HII</fullName>
            <shortName evidence="13">RNase HII</shortName>
            <ecNumber evidence="6 13">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rnhB</name>
        <name evidence="18" type="ORF">FAD_1506</name>
        <name evidence="19" type="ORF">HLB00_07755</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Berkeley</strain>
            <strain evidence="20">Y</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13 16">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15 16">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13 15">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13 16">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="6 13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000289">
        <property type="protein sequence ID" value="NOL60723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142936.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5E2"/>
    <dbReference type="STRING" id="74969.FAD_1506"/>
    <dbReference type="GeneID" id="84218099"/>
    <dbReference type="KEGG" id="fai:FAD_1506"/>
    <dbReference type="OrthoDB" id="33866at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07180">
        <property type="entry name" value="RNase_HII_archaea_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_A">
        <property type="entry name" value="RNase_HII_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020787">
        <property type="entry name" value="RNase_HII_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="17">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="NCBIfam" id="TIGR00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ARD85358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="NOL60723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="205" mass="23227" checksum="23573C8E32F79E06" modified="2017-06-07" version="1">MDECGIDEAGRGPLIGPMVMAILCGDRESLESIGVADSKKLSPGRRESLFARLQSYKYNFVIISPSEIDRYVEHQKLNVLEETYASKLASWAPASSTVYVDSFDVNELRLQSLLMENTKRQIVCRHKADEIYPCVSAASIIAKVIRDREIDKLHKDYGDFGSGYPSDPRTINFVKNALKNGINIDSIVRHQWKTYKSMLNKKLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5J5</accession>
    <name>A0A1V0N5J5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142958.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5J5"/>
    <dbReference type="STRING" id="74969.FAD_1571"/>
    <dbReference type="GeneID" id="31677062"/>
    <dbReference type="KEGG" id="fai:FAD_1571"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF7">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="462" mass="51615" checksum="C53EB56AF83B1274" modified="2017-06-07" version="1">MIFKINRSSGDLKSNVHKFIDLSALSTSSVAPAFSIAASYGVIAMYLGFYSIMAIIITFPIWLGAAILFRKFNRLYPSAGASYHWGNKIVSKRYGSLQAWIITLAYFFSIPPIVIPAGEYTAVLLYNTGIISYSIYSSTITIFLLGSAWILITLVASIMGARPTARLTEIFLVLELSIIAVFIIIAIYFLPGHTVNTVSPAWFIGFGALLKNPYKFMLAFPIIATIMDGWEIDSYASEESFNREKWPGTTGIIGLIAVFAIYLVTMTLMDIETPISLLSASLDPLATWSHYIIPQYSFVMDIAVIASTASSLWLTTYILSRAWYAMSREHLLPKQFGYINKTRKSPYANLIIIMIAAESINAVMLFVPSIESFFAQLLSISGIFLMMEFGIDSLTGIYLYSHRKNINMKHIYLGISIFSFTGFFVMIMFGIITNTLFIILIIILIIPGILIMFKNNQKIIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5K3</accession>
    <name>A0A1V0N5K3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor biosynthesis protein MoaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1584</name>
        <name evidence="2" type="ORF">HLB00_01500</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000041">
        <property type="protein sequence ID" value="NOL59512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142968.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5K3"/>
    <dbReference type="STRING" id="74969.FAD_1584"/>
    <dbReference type="GeneID" id="31677074"/>
    <dbReference type="KEGG" id="fai:FAD_1584"/>
    <dbReference type="OrthoDB" id="52767at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011589">
        <property type="entry name" value="UCP004961"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42206:SF1">
        <property type="entry name" value="METAL-DEPENDENT HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42206">
        <property type="entry name" value="METAL-DEPENDENT HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="276" mass="32149" checksum="B75768009969EF71" modified="2017-06-07" version="1">MSPYRTVFDNFAHIRRNGYYVDAAKEFLKYGGTSMNMVNFPDYFYTPDSHYEKLYRETIDVAKTVRNTGVDTVITIGPYPLDYFYFQSARKDPVDEMKRGIDMAASIITAGDADAMGEIGYPHFPVDEKVYSDSGVILEYALDVCHDHDIPLILHTEDMDEEGYLRVESIIKMHYSIDRVIKHHANATDIYFNDSITRSFVASRSNIKTAVSSGRDFLLETDYTDQKDKPGKVIPVYSVPKRAEMIKNLYENYDEIFHRIFEEVPFRIYRKEFFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5L6</accession>
    <name>A0A1V0N5L6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thy1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5L6"/>
    <dbReference type="STRING" id="74969.FAD_1526"/>
    <dbReference type="KEGG" id="fai:FAD_1526"/>
    <dbReference type="OrthoDB" id="8310at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20175">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="FLAVIN-DEPENDENT THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934:SF1">
        <property type="entry name" value="FLAVIN-DEPENDENT THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="Thymidylate synthase-complementing protein Thy1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="531" mass="61087" checksum="EAD0B5A6A5AD6027" modified="2017-06-07" version="1">MHRYIFIHRTDTIFMDDFSNNDRDVFLIKTDMIDRGALMSRYSRTANLDIREVYGKEFKNNPDRASNFYKRIFLDYGDESVAELTTAQMGIQNVSNIVTKVIEEPRIGLSYLEKSSRYVKYNKKVNGNYLFLRGENAGVGAMESKYNSYCNDLFDFYSAAYPEMMKYMEDANPIENFTFEIGGKNYKYTNLESVDENTLSKSYKSSLRSAVLDEIRALLPASTLTNIGISGNGRAFISLIERLKAYGTPEAEKYGELIYRELEPELPELIEDAVSAHGIAQIKYNNARDSIGNSFSNDTAKVPDIKVINFMDEKRAIDLATGMLLYGSSAGSSNVDIPPEKQYSILKELESLRGNRRHKLGRAFEGITYSFEVNMNYGAFREFQRHRFFSIIRKPLSTQYGYDIPENLGKIPELRSRYVELMDEARILYNDIMGRSGRKIAQYVVPYAYKYPVVFSSNLNELTYFIELRSNQQVHPDLREVALDIYSEIKKIHPHLATLIKFVDTGDYRLGRLPSEVKKESRRKTLSGEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5N1</accession>
    <name>A0A1V0N5N1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5N1"/>
    <dbReference type="KEGG" id="fai:FAD_1580"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="65" mass="7598" checksum="519A1E6F97773379" modified="2017-06-07" version="1">MNGFSGSLSISVFKLKINLSGAIFNYKILQRMRKTNCENAYLYSVLIISLHVYITKSRYEVFKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5N9</accession>
    <name>A0A1V0N5N9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L18e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1598</name>
        <name evidence="6" type="ORF">HLB00_01565</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000041">
        <property type="protein sequence ID" value="NOL59524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142977.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5N9"/>
    <dbReference type="STRING" id="74969.FAD_1598"/>
    <dbReference type="GeneID" id="31677088"/>
    <dbReference type="KEGG" id="fai:FAD_1598"/>
    <dbReference type="OrthoDB" id="11309at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003079">
        <property type="entry name" value="PRK04005.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="122" mass="13576" checksum="352FAD7BF1A4CEC9" modified="2017-06-07" version="1">MSIKVERKTSVYLIDVINNLLERSRESQSIFWRDIASRLNSSRNHYADVNLGKLDRVVSEGDTVVIPGTLLSSGILHKKVRIAAVKASDKAKLKLAESGSEFIELKDLADENPKGTNLKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5P3</accession>
    <name>A0A1V0N5P3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication complex GINS family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5P3"/>
    <dbReference type="STRING" id="74969.FAD_1585"/>
    <dbReference type="KEGG" id="fai:FAD_1585"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11714">
        <property type="entry name" value="GINS_A_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="26647" checksum="81478467D3CACD05" modified="2017-06-07" version="1">MAMVFVMIMIDISKYDKLLEDLKAMLFSERKSRKLNRIEPNFYKNIHSLFVELTEEKDRVVSSDITEYMEITKLLDEVRKNFKAFFQVRFEKIGKYSVYDEIEEYLYNMSPEEKNIMKELNAQMKGYYDDFTGITRQTEEIPEMPEEEKTVEEPPEKTITEPEIEEAPVAEEMVLVRIIKDQPPIAQPDRDYYLHRNDILYISGSFAKMLSSHGVCSYIEKGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Q6</accession>
    <name>A0A1V0N5Q6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142986.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Q6"/>
    <dbReference type="STRING" id="74969.FAD_1636"/>
    <dbReference type="GeneID" id="31677125"/>
    <dbReference type="KEGG" id="fai:FAD_1636"/>
    <dbReference type="OrthoDB" id="110773at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053172">
        <property type="entry name" value="Tn903_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053520">
        <property type="entry name" value="Transposase_Tn903"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033579">
        <property type="entry name" value="transpos_IS5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631:SF3">
        <property type="entry name" value="ISSOD12 TRANSPOSASE TNPA_ISSOD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="142"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="321" mass="37884" checksum="C3411E5CFBCC69A1" modified="2017-06-07" version="1">MTPQINNKINRSIKRYWLGSNRRWGKYNESLVDRIEYLVDRIEYLADRIEYLADLSFIKDNDRLLEEKNNGKIGHPYKVPDALIIYLARLRSIFSIPFRSLEGVLRSLAIIANIKSISYSEIFRRIRRIKPELNNINSKLDCIIDSTGSKITIRGDYLRHKWHKKRRGWIKLHVIISLKDVTVLSFTITDEHTHDSKAARKLLSKMKNNILRLFGDRGYDSKYIYNMFGYNAIIPPRKNASTEFRGSPARAKIVRFIKKNSMEQWKENNSYGKRWLVEIYFSGLKRVMSEVIKAKKIEYIVQELALKVVNYNIMRGMTHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5R0</accession>
    <name>A0A1V0N5R0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1613</name>
        <name evidence="2" type="ORF">HLB00_01650</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000043">
        <property type="protein sequence ID" value="NOL59540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886745.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5R0"/>
    <dbReference type="STRING" id="74969.FAD_1613"/>
    <dbReference type="GeneID" id="16024879"/>
    <dbReference type="GeneID" id="31677103"/>
    <dbReference type="KEGG" id="fai:FAD_1613"/>
    <dbReference type="OrthoDB" id="56760at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="455" mass="53101" checksum="78CE6EAF2ACC8FDE" modified="2017-06-07" version="1">MITKSNSKEAEKAFIDNIKKFFDNPEIILPECTDSCFMCPIKGYAKKIQKMKESSNFGKYHNSADQFLAGVSETYRILESEKAPLMGVIKTNYGSVNYCKRGNTDELIISGVQNYDNDIYRLLAFTNTVKLKKLRVYSTRNYFTATCREKIDIDFITDLLNEENIPFTRAEDRIVIGTTGNKITVSAYDAILDVYEDFDHNIVFTLLKHMLLPDMPFKIQSDFMDFIPDNPDIITEFIHKRLSTKQLLSRLRKDKINYAIKNNYYIINYENYGIDEFLDKLEFDDRLKPFIREKIASKGFVLDSPSQRKVLEYLFPEYKNEIVRLLYDLTDAEIKSLKGNPMEIMENAKLLKSKKSVKSKIMEPWSENSRYLIDLITYYFNYGKSDSINFGRKNMNNDIQKSIYYAFLEAIGSGEGWMFTENQILLGKRIYDYVNDMVNDRNINDQLKKIKGIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5R6</accession>
    <name>A0A1V0N5R6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Elongation factor 2</fullName>
            <shortName evidence="10">EF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fusA</name>
        <name evidence="12" type="ORF">FAD_1644</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886775.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5R6"/>
    <dbReference type="STRING" id="74969.FAD_1644"/>
    <dbReference type="GeneID" id="16024909"/>
    <dbReference type="KEGG" id="fai:FAD_1644"/>
    <dbReference type="OrthoDB" id="6290at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01514">
        <property type="entry name" value="Elongation_Factor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_A">
        <property type="entry name" value="EF_G_EF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="10">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="732" mass="79996" checksum="A0BEBE4E30DF6F58" modified="2017-06-07" version="1">MGRKEENVAKAMKLVEHPELIRNIDIAAHIDHGKTTLSDNLIAGAGMMSEDLAGKQLLLDYDEQEQARGITINAANASMVHEVDGKEFLINLIDTPGHVDFGGDVTRAMRAVDGTVIVVDSVEGVMPQTETVVRQALKERVKPVLFINKVDRLINELKLNGDEMQKRFIKVITDVNKLITKYAPKEFADSWLVNVKNGTVAFGSAYHNWALSVPAMALFKVTFKDIVDLVSAGKQKELAKKAPLHKVVLDMVTKNLPNPAVAQKYRIPQIWHGDLDSEIGKAMEKCDDNGPVSMMITKILIDPHAGEIAVGRVFSGIIRKGSELYVTGAGKSKVQLLSMMVGPDRISIDEIAAGNIAAVVGLKGAIAGSTVSSLQDMDDFEPMSHYSDPVVTLAIEAKHTADLPKLIDVLRSVSKADPSIQVDINQETGEHLISGMGELHLEITMYRIKNDYHVDVVTSAPLVVYRETVDKTGGPFEGKSPNKHNRFYFKVEPLPEGVVQAILEGKVPDGSKIKDKKAVMAILEEAGLDHNEARGLVSIHGANLLLDMTKGIQYLDETMELLIESFNESLDKGPLANEKVYGLKVSLMDAKLHEDSIHRGPAQVIPAGRNSIYGAMCQAGRVLMEPMQKVFISVPQELMGPVTSELQQRRGVVEDMQQNGEEITVIANAPVSGMIGFASAIRSATGGKAIWSSENSGYQRVPYELQAGIVAKIRERKGLKPEPYDESYYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5R7</accession>
    <name>A0A1V0N5R7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-serine dehydratase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142966.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5R7"/>
    <dbReference type="STRING" id="74969.FAD_1579"/>
    <dbReference type="GeneID" id="31677070"/>
    <dbReference type="KEGG" id="fai:FAD_1579"/>
    <dbReference type="OrthoDB" id="311867at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="258"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="364" mass="40760" checksum="BAB2F9C51018F59D" modified="2017-06-07" version="1">MNVEQALLITSETPYMAVDLNQTMDNIRKFQEIANKGHKTLRPHSKTHKIPYLAKLQMEEGASGVCVQKVAEAEVMFNGGISDILISNEVIDKRKCDRIARLSKNNCRISVAIDSLEGATNLSESAAYLNRVIPVLIDINIGMDRCGIDPEEVLKFHSELKKLPNIRVEGIMAYDGQVHSPRAVEREEMVNRERVIVHDIFQKLKKTDPDIKVLTVGGTPSSEIWSHFEEVSEIQPGTYIFYDMHCQEMGLCSMDEVSMGVVGQVMSMKQGKRIVLDAGYKSISLDQGVYPVAVNQKGIVGKVVSMSEEHTVIKPDQGDIKLGSKVLLLPYHACTTTDFWDYTWIYDGKALPVMTKIMGRGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5R8</accession>
    <name>A0A1V0N5R8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886761.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5R8"/>
    <dbReference type="STRING" id="74969.FAD_1629"/>
    <dbReference type="GeneID" id="16024896"/>
    <dbReference type="KEGG" id="fai:FAD_1629"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="179" mass="20582" checksum="90E0C8CEDB0C007F" modified="2017-06-07" version="1">MTKENNMEKTEDNKNYECDLSVRWGHIDPSILPFDDLDKEIMCFLRYNARMSNAEIAKMLNTSEATVRRRINELVRRKIITGFSALVDLHAIENSIKVCIRIDTEGDRLDAIADSLAANPNVLSLYRRRGQNQLLLQGLFLNLETIQEFEDSLARKDGIVKYDTMVVSKAFKKDPWVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5S7</accession>
    <name>A0A1V0N5S7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carnitine dehydratase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1590</name>
        <name evidence="3" type="ORF">HLB00_01530</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000041">
        <property type="protein sequence ID" value="NOL59518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142974.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5S7"/>
    <dbReference type="STRING" id="74969.FAD_1590"/>
    <dbReference type="GeneID" id="31677080"/>
    <dbReference type="KEGG" id="fai:FAD_1590"/>
    <dbReference type="OrthoDB" id="28444at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="372" mass="42058" checksum="C815450E41ADEC59" modified="2017-06-07" version="1">MKRVIELGQIVAGPTAGLIFADMGFEVIKVEKPCSGDISRELNGTSAGTFMYYNRGKKSLELDIKTDFGKEVLTKLLSTADIIVENMAPGTMKKIGFSYEDVKKINSRIIYVSIKGYMEGPYENRKSLDYPIEIESGLAYMTGTKDRPMRMGASIVDMVAAILGVTKAFQLISENKGGLVEIGLFETAMFLAGQHIATYEIEKKDLEPINEMNFAWGIYDYFMSSDNKKLFIAVATDDQWKKFCEGFGLQSIITDEKFSSNNARYMHRDFLIPLIQKKLLSMKYEEIKNVLDLYNISYGTLNKPWDLLHDPQALKYMVNMNYNNNSYEVPRLPFSVAQNNNAPTLGNCTKKILSDLGYSDTRIEEAIKTMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5U4</accession>
    <name>A0A1V0N5U4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143001.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5U4"/>
    <dbReference type="STRING" id="74969.FAD_1658"/>
    <dbReference type="GeneID" id="31677147"/>
    <dbReference type="KEGG" id="fai:FAD_1658"/>
    <dbReference type="OrthoDB" id="31247at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004426">
        <property type="entry name" value="MJ1210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00162">
        <property type="entry name" value="proteasome assembly chaperone family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610:SF7">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27906" checksum="EBCCFD5202706015" modified="2017-06-07" version="1">MEKIMFKNYEEPELNSPIFVGGLPGIGNVGKITVDYFVDKLKMKKLADVYSEFLPPQVFINNNVVHLVRESLYYKKTSGEHDLIFLTGDFQGTTQEGQYELSYRMLEFLKKYEVSMIYTLGGYSVGKIVEKPRVLGAVTDKKLIKPLARKGVVFSEGEPSGGIVGSAGLILGMGTELFSIPGACFMGETSGYFADPKSAREIIMVLAKVLKTRINLKDIDEKTRQLEDITEKMKQEAQNKAPKDDLGYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5V5</accession>
    <name>A0A1V0N5V5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF981 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886763.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5V5"/>
    <dbReference type="GeneID" id="16024898"/>
    <dbReference type="GeneID" id="31677120"/>
    <dbReference type="KEGG" id="fai:FAD_1631"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009324">
        <property type="entry name" value="DUF981"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06168">
        <property type="entry name" value="DUF981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23440" checksum="34193D12CE9245CF" modified="2017-06-07" version="1">MLNADYGLGDKNMGFVDDTPMELFLISLVAIVSIYMSAWVYIEFRKNGAKNVNEILKPGALPLGILGAIIVLMGLWGEMVWPLPGAYNILFDDPFMFLGIIVLMMAGTIALKQKLQYVGILAFFAGIISIWYGANAYVDKLTSSPIAMFGLFLAFGLTGVFTFPTTLIYDILPGKTKVSNVWTVVLVLFWIGLVVSAVVAALIGLEAIPAHLVSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5W1</accession>
    <name>A0A1V0N5W1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886839.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5W1"/>
    <dbReference type="GeneID" id="16024970"/>
    <dbReference type="GeneID" id="31677189"/>
    <dbReference type="KEGG" id="fai:FAD_1698"/>
    <dbReference type="OrthoDB" id="358871at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="59" mass="6541" checksum="9DF3AA1802800DF4" modified="2017-06-07" version="1">MTDIKCRKCGEIFKKPRWGFKPLEYKAGMKMPGGLVALGAIIVCPKCGFEGSLKEYDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5X1</accession>
    <name>A0A1V0N5X1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1667</name>
        <name evidence="6" type="ORF">HLB00_00445</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000012">
        <property type="protein sequence ID" value="NOL59308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_171481159.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5X1"/>
    <dbReference type="STRING" id="74969.FAD_1667"/>
    <dbReference type="GeneID" id="31677158"/>
    <dbReference type="KEGG" id="fai:FAD_1667"/>
    <dbReference type="OrthoDB" id="44250at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051782">
        <property type="entry name" value="ABC_Transporter_VariousFunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42939">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN ALBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42939:SF1">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN ALBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL59308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="283" mass="32267" checksum="22BA115708949ED3" modified="2017-06-07" version="1">MDGIYFGNATKKFDDITIFENSTFRVDKGVTLLISPNGSGKSTIIYLIMGNYRINSGEIYVNGYNPVNNHRLAFLNTSLMPENPVYFGSGTVREHISLFSRLKGVASSEIYGFLSYFKMEHIINSRISSLSMGEAQILYISCYLSGNYKLYIFDEPNSNLDQPNRRRFAEAVKLKQLNSNSIFLITSHINDELNQQANQILTITGNKVRAFYRDDINIAYALKFYDIKTVEGKLKGLKHFMVNDSIVIKNASIRDIIDVIPESNIKEITRIPPAMVEYYENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Z0</accession>
    <name>A0A1V0N5Z0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1729</name>
        <name evidence="3" type="ORF">HLB00_00200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000007">
        <property type="protein sequence ID" value="NOL59259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143061.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Z0"/>
    <dbReference type="STRING" id="74969.FAD_1729"/>
    <dbReference type="GeneID" id="84218350"/>
    <dbReference type="KEGG" id="fai:FAD_1729"/>
    <dbReference type="OrthoDB" id="57427at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="251" mass="28608" checksum="A0480D3731FB48F7" modified="2017-06-07" version="1">MDKYSNTKEFFSKNSENYAKSQSHAKDRDLDILMEMLSPQAGMIGLDAATGSGFTAIRLAKKIGKVYALDMVDNMLLETAKLAEENGLHNVFPVKGYVDSMPFENEKFDIVTCRRAAHHFDDKDEFASEAFRVLKANGMIGIDDMTVPDSIINDLNEVERIRDHSHMYAASTDGWIRILSRAGFTGLKYKVYSRRVSFEQWLYPVEINSPEGKKSLEYFQNARDEFLSSIQWDGKSFQKSWVVITGVKEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N605</accession>
    <name>A0A1V0N605_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sterol binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sterol carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1722</name>
        <name evidence="3" type="ORF">HLB00_00165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000007">
        <property type="protein sequence ID" value="NOL59253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143055.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N605"/>
    <dbReference type="STRING" id="74969.FAD_1722"/>
    <dbReference type="GeneID" id="84218343"/>
    <dbReference type="KEGG" id="fai:FAD_1722"/>
    <dbReference type="OrthoDB" id="56072at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="110" mass="12503" checksum="1F474CD3C0C3564E" modified="2017-06-07" version="1">MKEVLNDLVKKLNDKIASDQTYAKKLQSITKSIDIVFDDKDSYYFKVENGHITEPQEGKIDADITVTVSSDVFNKILSKEINAMDAYMKQQIKIKSSLMDKLLLSDLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N619</accession>
    <name>A0A1V0N619_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="8">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_1759</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143072.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N619"/>
    <dbReference type="STRING" id="74969.FAD_1759"/>
    <dbReference type="GeneID" id="31677250"/>
    <dbReference type="KEGG" id="fai:FAD_1759"/>
    <dbReference type="OrthoDB" id="27922at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="4"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="9">
        <location>
            <begin position="326"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="429" mass="46844" checksum="B5B9A4E1DEE8D278" modified="2017-06-07" version="1">MDFDAAIIGSGAGGYYSALRLLKHGKKVLIIEKEKFGGECLNYGCIPSKALIELSENIGYLHDMPGVTLNYKIDMKEWQKWKESMVKRITGGAEKLCISLGAKVIYGVGSVKDRNTVTVNGTDYTAKNIIINTGSVPVKIKGIDDVYYNREMLAVENIPSKLVIIGGGYIGVEMGTAFRKLGSEVYIVEMKDRILPEIEEDLAREVDKRLRKLGVNIMTGMKVLSVKKDKNYKVAIEGSDTIEADTVLMSVGRIPNTEGSGIEKLGIEMDGRFIKTDSHKRTNVPNIYAIGDVSGGPMLAHKAFYDGYVAAENILGNDTVVDYRAMPFVVYTDPEIAFTGKAGTKSNKVPVLANPRSLTMNQQDGFFKLYYDDDGTITGAGVAAPRSSESITEISLAVESGLSIDDLFLTIHPHPTVSEGLKDAAERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N647</accession>
    <name>A0A1V0N647_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1725</name>
        <name evidence="10" type="ORF">HLB00_00180</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000007">
        <property type="protein sequence ID" value="NOL59256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143058.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N647"/>
    <dbReference type="STRING" id="74969.FAD_1725"/>
    <dbReference type="GeneID" id="84218346"/>
    <dbReference type="KEGG" id="fai:FAD_1725"/>
    <dbReference type="OrthoDB" id="56630at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="Polyprenyltransferase_UbiA-li"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="281" mass="31691" checksum="BF52679B1D9D02AF" modified="2017-06-07" version="1">MKFRDIAEFIKLEHTLFDLPFIYAGAIIASGGSYNFVKYIIIFITATSARGAGMSINRIMGLKYDKTNPRKKNWALVTGKMKKIDAYALTLLLIAIFEVSTYFLNRVVLALSPVVILFFIADPLMKRVTSWRHLFMGLTIGLGVLGGFLAISPVAPPLIIYLVVLISTFWIAGFDIIYTIPDIDYDRANNLKTLNVKYGLKNGMIISSLFHIFTIALFIFIAFIVKNIYYDILLVPIVALIIYQHIVVNPSNLKTIRVSFFNANSFIGIIFLAGMIISFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N657</accession>
    <name>A0A1V0N657_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143100.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N657"/>
    <dbReference type="STRING" id="74969.FAD_1799"/>
    <dbReference type="GeneID" id="31677289"/>
    <dbReference type="KEGG" id="fai:FAD_1799"/>
    <dbReference type="OrthoDB" id="56053at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43252">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR YQJI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43252:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR YQJI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="138" mass="16345" checksum="FAF241B67BE5E7DB" modified="2017-06-07" version="1">MRYHLSDMLILEQVSESPKKPYRIIKGIVGKFDIEYKPSTGMIYPAIDRLLKAGYIKKTIDGYIITEEGKKYRSNNRENYEKLISNFMDNKLFFRNLRKAVRDLISTIKESDKSYIRENQETIIEEIGEISRKIKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6B2</accession>
    <name>A0A1V0N6B2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-aminoadipate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lysN</name>
        <name evidence="8" type="ORF">FAD_1777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143083.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6B2"/>
    <dbReference type="STRING" id="74969.FAD_1777"/>
    <dbReference type="GeneID" id="84218400"/>
    <dbReference type="KEGG" id="fai:FAD_1777"/>
    <dbReference type="OrthoDB" id="372018at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000053">
        <property type="entry name" value="Aminotransferase, class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="60"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="400" mass="45471" checksum="DB0A65F579E99310" modified="2017-06-07" version="1">MEFQFSNKMKNIKSSEIRELLKYIHMPGMISFGGGLPNPESFPGEELRNILDDIMENYVSSALQYGQTNGLPELKEQLAAYLKSDENINVDPENILLTTGSQQALYALPLIFANEGDYVITEAPTYVGMLSSLTASGIRSQSVSMDDNGMITDELEEKLKSMKSKGIMPKFIYTIPTFQNPAGYTMPLDRRKHLLELAQQYNIPVIEDNPYGDLRYSGKKLPTLKSLDTNDMVTYLGTFSKIMAPGLRTGFTVSQPEVLGEFNKLKQSLDLTSDSLSQYIAYEYIRKGIIYKQIPKTIELYRRKRDIMLEALDDEMSDATWSRPEGGMFLWVKLNKDMDALKMLKRAINNKIAYVTGSAFYHNNPEMNTMRLNFTYSSDEDLKEGVKRLAKTIKEEKQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6H2</accession>
    <name>A0A1V0N6H2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Argininosuccinate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143122.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6H2"/>
    <dbReference type="STRING" id="74969.FAD_1849"/>
    <dbReference type="GeneID" id="31677339"/>
    <dbReference type="KEGG" id="fai:FAD_1849"/>
    <dbReference type="OrthoDB" id="27337at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005000">
        <property type="entry name" value="PRK06389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="1">
        <location>
            <begin position="88"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="438" mass="50175" checksum="EB213CF6013390F9" modified="2017-06-07" version="1">MKIWSGSAAPESGNEAYRIMLEKDIDVDKYLIPYEILSLMAYNLNIYERNISDRNNSKATLKELLSLYNRKISLDPDLEDVHGNIENIAIRETNGAANNMRMFMSRNEQVHTDVNFFLIDILLEYEKIIYNTITGLEKLTQNGIMPGYTHYRQGMPVTFQTYVDFIKNIMVYNFNNIDSILNELKELPLGYGSGFGSMSDANFKEVAEYMGMKKQIKNPLFSFMLYSDNYIKVLSAINSFLIDISRIFQDMIIFSGDEMKIIELPAGYVTGSSLMPNKVNPDFLEIFQGYAAKSISLMNLLYSGTINKTTGYHRDFQILKDEVIPFMVELKGVLNGFPELFSGIKFNKEASERIIGNSIYATYNSKLNFKNNGNWKESYKMTGDMIRSGKALKPYMPEDVVSYNNFGFLRDKIENNISSLENGKKKLLKMVNDIISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6I2</accession>
    <name>A0A1V0N6I2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_1860</name>
        <name evidence="11" type="ORF">HLB00_05645</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000189">
        <property type="protein sequence ID" value="NOL60316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887008.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6I2"/>
    <dbReference type="STRING" id="74969.FAD_1860"/>
    <dbReference type="GeneID" id="16025142"/>
    <dbReference type="KEGG" id="fai:FAD_1860"/>
    <dbReference type="OrthoDB" id="8297at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL60316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="276" mass="29888" checksum="09CDAC6B704370AD" modified="2017-06-07" version="1">MAGTIKINDPPPRPSLTPGKSVKYNVKHTIMVMSGKGGVGKSTVATNLAVTLAQKAFKVGLLDADINGPDDPKMLGVEEAKAFGNEEGKIEPAKTKYNVDVISMEMALPTHDTPVVWRGAIRHKAVQQFLEDTSWTDKDLLVIDLPPGTGDEPLSICQLIPDADGIVIVITPQEVALLDAKKAINFARKVNMPILGIIENMSGFVCPHCGQETDIFKKGGTEQIAKEYNIPYLGNIPIMPEIVQDSDSGIPAVANNDYIKKFFDVVADNLIKNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1G0</accession>
    <name>A0A1V0N1G0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division control protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cdc6_2</name>
        <name evidence="7" type="ORF">FAD_0001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143129.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1G0"/>
    <dbReference type="STRING" id="74969.FAD_0001"/>
    <dbReference type="GeneID" id="31675515"/>
    <dbReference type="KEGG" id="fai:FAD_0001"/>
    <dbReference type="OrthoDB" id="195574at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055237">
        <property type="entry name" value="Cdc6_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22703">
        <property type="entry name" value="Cdc6_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC1/DEAH AAA+ ATPase" evidence="5">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 AAA+ ATPase-type lid" evidence="6">
        <location>
            <begin position="186"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD83937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="362" mass="40255" checksum="C37433E50E86C87A" modified="2017-06-07" version="1">MIVANPAPLDTSYVPEKLFFRDDKIAAIRSAVLAPAGNGISNNIIIHGDSGTGKTSTVKFLMRENKSIIYENALSFRNVKNLLEHVISRLGKPVSYHGLSYSEIFSMLNSIISFRGDIVLVIDEATGFLKGDTAGLYNLFRASEIYGAGLSTILISIESPFMYMERKYGTIVELKFNKYSSDEIQRIITDRASMALEPGTCTDSILGYISEISGKFGSARFAIELLQKAAYMAEYRLSKTIENDDVRSAVSLINPYITESKLSLLDRRELVILLAICILLPDTLYVDVPSIEKEVQLQGEEYGIQYKKTEIYRVIRKLESLDIISSSLKSSGNRSSVSKLVSINDVPVSILSIKIRDLISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1I0</accession>
    <name>A0A1V0N1I0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0044</name>
        <name evidence="8" type="ORF">HLB00_02685</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000086">
        <property type="protein sequence ID" value="NOL59740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141262.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1I0"/>
    <dbReference type="STRING" id="74969.FAD_0044"/>
    <dbReference type="GeneID" id="84218535"/>
    <dbReference type="KEGG" id="fai:FAD_0044"/>
    <dbReference type="OrthoDB" id="10348at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055174">
        <property type="entry name" value="Pus10_THUMP_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22023">
        <property type="entry name" value="Pus10_THUMP_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10 THUMP" evidence="6">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="5">
        <location>
            <begin position="156"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD83979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="380" mass="43627" checksum="0FEFE556B15967B3" modified="2017-06-07" version="1">MDDFINLFSHNLCIRCTGRIFANIDTGMTDYQRGTMLAFAYKSFYGTYNAPDTCWLCNGIFNEFDKYFNMVKDAIGTKEYTTFLIGSKFDPATLLEEEKIQNKYGNNGESIKKEFNREFGKYFSSISGKEFSKDADIVIEINTIYDNVNLIIRPLYIYGTYKKERRDIPQTRWINGSGDSIESLIGEKLLKFTGGKNYKLHGSGREDVDVMMLGNGREFIMEVDEPEVRNFPVKEFMEEVNNSGNGISISNLEFTGKKRVKEIKEATYDKIYRAVVECNTPINENTLLMAVNTFRNFTISQRTPTRVIGNRSDLIRKKEIKYINIEDIHDKEAVVKIRSQSGTYIKELINGDGGRTTPSLSSVYGYELKVKCLDVLKIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1I8</accession>
    <name>A0A1V0N1I8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0021</name>
        <name evidence="6" type="ORF">HLB00_05665</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000190">
        <property type="protein sequence ID" value="NOL60320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887032.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1I8"/>
    <dbReference type="STRING" id="74969.FAD_0021"/>
    <dbReference type="GeneID" id="16025167"/>
    <dbReference type="KEGG" id="fai:FAD_0021"/>
    <dbReference type="OrthoDB" id="30763at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017158">
        <property type="entry name" value="Tscrpt-reg_CBS-contain_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037253">
        <property type="entry name" value="HTH_CBS_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="73"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD83956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="192" mass="21448" checksum="AD5470443FD5C034" modified="2017-06-07" version="1">MLPSIEELRKMRKSLGISQKELARISGVSQSYIARLEKGEINPAYDKVRKIFEYLNNSGNRAKDIDIKAELIMTKDVDTCEMNDSIISALNRMREKGYSQLPVVTSDKRIIGTITESNINDMLIKGTSIESLKHLIIKKVMGSVLPQLDKNSPISMIYPLLKYSNAVLIVDGTELKGIITKADVLKAVETYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1J3</accession>
    <name>A0A1V0N1J3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF131 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141312.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1J3"/>
    <dbReference type="STRING" id="74969.FAD_0089"/>
    <dbReference type="GeneID" id="31675601"/>
    <dbReference type="KEGG" id="fai:FAD_0089"/>
    <dbReference type="OrthoDB" id="137740at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002849">
        <property type="entry name" value="DUF131"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00304">
        <property type="entry name" value="TIGR00304 family membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01998">
        <property type="entry name" value="DUF131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6654" checksum="0262FBB0D8F613CC" modified="2017-06-07" version="1">MQHTTEHEKEEKESHFGGFLMIGPIPVIFGNDKKMVYISIAVAIFIIALYLSFTFHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1J5</accession>
    <name>A0A1V0N1J5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-binding protein FAD_0075</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0075</name>
        <name evidence="6" type="ORF">HLB00_07330</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887084.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1J5"/>
    <dbReference type="STRING" id="74969.FAD_0075"/>
    <dbReference type="GeneID" id="16025220"/>
    <dbReference type="KEGG" id="fai:FAD_0075"/>
    <dbReference type="OrthoDB" id="7912at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00026">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022889">
        <property type="entry name" value="DNA_bind_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003268">
        <property type="entry name" value="PRK04239.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="113" mass="13481" checksum="D0FD048309067750" modified="2017-06-07" version="1">MDNDDELNRIRQRKLEEMQRNQQQGQYDEENRKQIQEEEARRQQILRQILSTEARERLSTLKLVRPDLVSNVENQLIQLAGMGRINRVIGDEELKGILSRLIGNTRETKIERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1L1</accession>
    <name>A0A1V0N1L1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="4">HMG-CoA synthase</shortName>
            <shortName evidence="4">HMGCS</shortName>
            <ecNumber evidence="4">2.3.3.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds that are building blocks of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with acetoacetyl-CoA thiolase that catalyzes the precedent step in the pathway and with a DUF35 protein. The acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site, which allows for efficient coupling of the endergonic thiolase reaction with the exergonic HMGCS reaction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the thiolase-like superfamily. Archaeal HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887061.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1L1"/>
    <dbReference type="STRING" id="74969.FAD_0050"/>
    <dbReference type="GeneID" id="16025196"/>
    <dbReference type="KEGG" id="fai:FAD_0050"/>
    <dbReference type="OrthoDB" id="5812at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01409">
        <property type="entry name" value="HMG_CoA_synth_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004656">
        <property type="entry name" value="HMG_CoA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00748">
        <property type="entry name" value="HMG_CoA_syn_Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003274">
        <property type="entry name" value="PRK04262.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal" evidence="5">
        <location>
            <begin position="219"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>(3S)-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>(3S)-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>(3S)-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <note>ligand shared with acetoacetyl-CoA thiolase</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>(3S)-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>(3S)-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <note>ligand shared with acetoacetyl-CoA thiolase</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>(3S)-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>(3S)-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>(3S)-hydroxy-3-methylglutaryl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD83985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="351" mass="38189" checksum="4C42C22C4DE3365F" modified="2017-06-07" version="1">MSGIVSYGSYVPIYRIKPEEIARIWGDDPEKMKNNLFILSKSVPSPDEDVASISVEAARNALKRININPGDIGAIYVGSESHPYAVKPTATIVAAAIGMPLEYFAADYEFACKAGTAGMQNVKAMVDSGYIKYGIAIGSDTSQGAPGDALEYSASAGGTAMIIGKDNVIAEINDTLSVSTDTPDFWRREGEPYPRHGERFTGDPGYFKHVLAASKAMMERMGTKSSDYDYVVFHQPNGKFPTRAAKMLNFTEEQYKTGLLTPYIGNTYSGSTMTGLSAILDEAKPGDRILAVSFGSGAGSDAFDITITENMKNYHRENAPGVRKMIENVKFIDYAIYTKFRKILVMGDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1M0</accession>
    <name>A0A1V0N1M0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0062</name>
        <name evidence="3" type="ORF">HLB00_07395</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000270">
        <property type="protein sequence ID" value="NOL60651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141277.1">
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    </dbReference>
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        <location>
            <begin position="15"/>
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            <begin position="40"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
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        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="158" mass="18063" checksum="43F07648B99FFD8D" modified="2017-06-07" version="1">MSSFKDGIIAGLKSGFIYFIIASIVNVIILYIFSAEFAFAYGYTITSKNLSLLFTVLLVSQVRDLLILGLVFGVFYSILLAKYFDIIPRNTLDGKIKFMVIAYWLVFFVIITVYSLGLLGIYDLIFYFITYIVANFFLSLLFGSLLKKYNSRYLTQSE</sequence>
</entry>
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        <submittedName>
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        <name type="scientific">Ferroplasma acidiphilum</name>
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            <authorList>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Berkeley</strain>
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        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ARD83991.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="NOL60118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="78" mass="8908" checksum="CBD3EA7F89AE938C" modified="2017-06-07" version="1">MGGKKQHYGFTRNIDFMAIVTVLLALLIEIELWLYFAGFHALITILVYVQIALIVLIAIANSIRRIIIGKKEHRSSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1P5</accession>
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        <name type="scientific">Ferroplasma acidiphilum</name>
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                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="6"/>
            <end position="27"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43615" checksum="997519EC45D0F39E" modified="2017-06-07" version="1">MFFVLVIGIIAGFISGFALAIVIYSMINRKMSGNVEDKLKASMHEFIESESRNLLNTGTIAFKNALEIERSERENTGLKLNGLIEPLKDSLKTYQTYIENIERERKSESGALKDNLDTLSRKITDLEHDTIKLSGALKNPSIRGKWGEITLRRTVEIAGMTPYCDFIEQAVSEDRLTKPDMIIKLPNRRTIVVDSKVPLSGYFEHMNGEEDKTFLDKYMLAFNSHVRDLASKKYWEKFDGSVDFVVMFLPMESLLSLVMSNKPEIIEDAISKKVIIATPVTLISLLLTVHMGWKDINTVENFNGLIAKIKEFYNNMQTFVGDLNETSKNLSKSIDSFNRMTRDIKNKLEPVIENLIKTDVANNGANMDLHGVEKSPDDYDSYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1V0N1S9_9ARCH</name>
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        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L24</fullName>
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    </protein>
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        <name evidence="8" type="ORF">HLB00_02270</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ARD84100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="NOL59659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1S9"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="97"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
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            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="NCBIfam" id="TIGR01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="166" mass="18348" checksum="2BC134A45047AA67" modified="2017-06-07" version="1">MLNTKINVSLNRDLKKKYGIRRFPVVKGDIVKIVSGSRKGEGGKVIGVSHKTKKIAIEGITIAKADGKQVEYYIDHSNLVVTKLDLSIEGRFNKIKEITARRNLPTPEPEKPAESEATPVESEPVDVGESSGETIDLPEDNGDELEEDNSDTEETDDIKEDDDNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1U3</accession>
    <name>A0A1V0N1U3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141393.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1U3"/>
    <dbReference type="STRING" id="74969.FAD_0193"/>
    <dbReference type="GeneID" id="84218681"/>
    <dbReference type="KEGG" id="fai:FAD_0193"/>
    <dbReference type="OrthoDB" id="8079at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040601">
        <property type="entry name" value="Trm5a/b_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF31">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18093">
        <property type="entry name" value="Trm5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="5">
        <location>
            <begin position="81"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="325" mass="36946" checksum="0E98DB0BAA096680" modified="2017-06-07" version="1">MERSCIRSSKISADDAIKKFRALGLLDTAYHIEQDENYVYIPLIRHIGGSINHDFKPREDVFTGIEKDSERRGLKNTGAPYIRLGNSIIFKSSISRRIVYKYASRLKVDNIYVETGKIRGIKREPSLKLIYGSGGETIVRESGVSYIMDLQKVMFSPGNINTRSKMKFIDFTGMVILDMFCGIGYFSLQILKNSRPARMVMCDINPDSIHYLKKNLQVNRIKSKVDVYTGDSRSVLPVMQADYIIMGNFNSINFIVAALLRSRIGTQISMHYLTPTESMNSTQDVIVDIARKLGYVIECIENTKVKSVGPHYQHMNAIFKVSRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1V9</accession>
    <name>A0A1V0N1V9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887146.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1V9"/>
    <dbReference type="STRING" id="74969.FAD_0140"/>
    <dbReference type="GeneID" id="16025285"/>
    <dbReference type="KEGG" id="fai:FAD_0140"/>
    <dbReference type="OrthoDB" id="55635at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="131" mass="14917" checksum="7152FF591EAB5A68" modified="2017-06-07" version="1">MKTKDREFNGKNIDLDKLSNVVEQYFQNEKFKTQLGKHPNGTLIQATKEGLLRSIAGMDRSYSITISGTPDNVKISIGMGKWLQNLGVAAIESFLLTPELAFFEVPESLWGFEIEDKFWKYIENQIDLGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1X6</accession>
    <name>A0A1V0N1X6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887166.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1X6"/>
    <dbReference type="STRING" id="74969.FAD_0161"/>
    <dbReference type="GeneID" id="16025310"/>
    <dbReference type="KEGG" id="fai:FAD_0161"/>
    <dbReference type="OrthoDB" id="5987at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="6">
        <location>
            <begin position="84"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="232" mass="24785" checksum="F084D415FA9CF25B" modified="2017-06-07" version="1">MGKHIVAQRRGHGSLTYRSPSHRHLAEIKHLSNGNYSIDDIIQAPGRNAPLLSLKNEQNEISYMIAFNGAFKGQKLYAGEVGNSNNGTTTTLSKIEDGTYVYNIENHPGDGGKFCRTAGSSGLIISHGNSVSIKLPSGKTRELNPNCKATVGVVAGSGARDIPILKAGKHIKYLQSKAKRPYTVRGVAMNAVNHPHGGGNHQHVGGPSTVARGSPPGAKVGRLSPKRRDKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Y7</accession>
    <name>A0A1V0N1Y7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit Rpo1C</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit A''</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpo1C</name>
        <name evidence="8" type="synonym">rpoA2</name>
        <name evidence="10" type="ORF">FAD_0205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141401.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Y7"/>
    <dbReference type="STRING" id="74969.FAD_0205"/>
    <dbReference type="GeneID" id="31675715"/>
    <dbReference type="KEGG" id="fai:FAD_0205"/>
    <dbReference type="OrthoDB" id="372142at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06528">
        <property type="entry name" value="RNAP_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00411">
        <property type="entry name" value="RNApol_arch_Rpo1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012757">
        <property type="entry name" value="RPO1C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02389">
        <property type="entry name" value="RNA_pol_rpoA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF32">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 8 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="9">
        <location>
            <begin position="118"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="505" mass="56661" checksum="35D7BF158127D8D5" modified="2017-06-07" version="1">MMSLVWRDTKKNVEQIAQNAPCGYAIDYMPEGKFDTAYISTDKVNVDYEVKISGISKYEPADDLIFKRKTGLKAILKIDSIRKIDRVPISEFDMEKGFKELASFAMGEKFQVDYKEKEAFHLSTEATSIMEDAESRGYKIPVSIANKLVKYRKAFPDSKYEKLLERVDKELRKREIDPFEAVGIIAAQSIGEPGTQMTMRTFHFAGVVEMNVTLGLPRLIEIVDARRIPSTPSMTIYLTEKYRKDENKVRELIKNLENTTIIDVAEIVTDVGNMELTIRMDSNKSRDRLVSIGDILSALEKRKGIIFAQVDDSNISIKLQQESFKSLYQVQEQLKSTPIKGVNKISRAIARIDPKEDAWVIYTQGSNLREVLNIEGVDSNRTTTNDIIEIENVFGIEAARNAIYREAENTLSEQGLNVDKRHLMLVADMMTFSGAVRAVGRQGISGRKSSVLARAAFEITSKHLLKAGLLGEIDPLAGVAENIIVGQPITLGTGAIDLVYRGNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N228</accession>
    <name>A0A1V0N228_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein Lsm2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lsm2</name>
        <name evidence="4" type="ORF">FAD_0221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N228"/>
    <dbReference type="STRING" id="74969.FAD_0221"/>
    <dbReference type="KEGG" id="fai:FAD_0221"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="74" mass="8398" checksum="F1A99B047CBFF12E" modified="2017-06-07" version="1">MNKMATLPMKMLEENLNKKVTLLLKDNRSLVGILAGYDEYMNMTLDDAEENGEVQRKIGKVIIRGSNVVRITTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N249</accession>
    <name>A0A1V0N249_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0281</name>
        <name evidence="2" type="ORF">HLB00_06465</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000224">
        <property type="protein sequence ID" value="NOL60475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887303.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N249"/>
    <dbReference type="GeneID" id="16025449"/>
    <dbReference type="KEGG" id="fai:FAD_0281"/>
    <dbReference type="OrthoDB" id="56414at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="93" mass="10681" checksum="C9CFC5EB4042C94F" modified="2017-06-07" version="1">MKIEIGEKCDFEIERSDIENVKEGSVIATYYSLGNPIYVELIINRSLSKEINKFFANTDKKSAIISIERISKSKYRITPTIVILNRQRGALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N269</accession>
    <name>A0A1V0N269_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylmalonyl-CoA mutase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N269"/>
    <dbReference type="STRING" id="74969.FAD_0301"/>
    <dbReference type="KEGG" id="fai:FAD_0301"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02071">
        <property type="entry name" value="MM_CoA_mut_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF3">
        <property type="entry name" value="COENZYME B12-DEPENDENT MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="149" mass="16266" checksum="5808A9920349B514" modified="2017-06-07" version="1">MENGKNRKYTEAPIKILLAKPAIDGHDRGIFVLAKAFRDAGMDVIYAGLLPTPEEVVDTAINEDVDVIALSLLNGAHMTAFRNVMESLKKRGVSDIAVVGGGIIPDEDKPALEKMGITGNFGPGTPLSEIISHIKKRAREIRKLRENEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2B3</accession>
    <name>A0A1V0N2B3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II DNA modification methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141482.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2B3"/>
    <dbReference type="STRING" id="74969.FAD_0312"/>
    <dbReference type="REBASE" id="195974">
        <property type="entry name" value="M.FacYORF312P"/>
    </dbReference>
    <dbReference type="GeneID" id="31675821"/>
    <dbReference type="KEGG" id="fai:FAD_0312"/>
    <dbReference type="OrthoDB" id="56674at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA methylase N-4/N-6" evidence="3">
        <location>
            <begin position="95"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="608" mass="70745" checksum="812FCC98BD7E82F9" modified="2017-06-07" version="1">MNEEVIVSKREDGRITVSVPYNPEYIAKLKKIKGYRWHPESKLWSFPSDNSTLNEILELFDKKDVNVPWPLEHGNSLETIPDSTIVFLTIKEAAVWASNYVGKNVTSSNISYLVQYGRIKKISHNGTTFVRKDDLIKYYQSFRGKRELEWKEQLGDDLNWALSFDYLREADTTKHVHRLHPYKGKFIPQLVEYFLDDHIDDFKKEVYFKKGDIVLDPFCGSGTTLVQANELGINAIGIDVSIFNSLISNVKISKYDFGILKLEISRITETLRNFISKSNEIQFEQKLSEAMTKFNNLYFPSPEYKYKLHRNEINESVYGSEKEAEFLPVFNSLVREFRIQLKQGNNGTFLDKWYLQPVRREIDFTYELINNIQNNTIKDVLMVILSRTIRSCRATTHEDLATLIDPISSPYYCAKHKKICKPLFSILSWWERYSTDTIERLEQFNKVRTNTFQFCLTGDSRTLDIPNSLNRDAPELAELVQNQKIKGIFSSPPYIGLINYHEQHSYAYELFDLPENTASEIGNMSLGQGREARNKYVIDISNVLINCKQYLVDDYDVFLVANDKFNLYPSIANKADMNIVEQFKRPVLNRTEKDKGAYSEVIFHLKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2C6</accession>
    <name>A0A1V0N2C6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_196795610.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2C6"/>
    <dbReference type="STRING" id="74969.FAD_0338"/>
    <dbReference type="GeneID" id="31675847"/>
    <dbReference type="KEGG" id="fai:FAD_0338"/>
    <dbReference type="OrthoDB" id="6027at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050714">
        <property type="entry name" value="Cobalamin_biosynth_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43182">
        <property type="entry name" value="COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43182:SF1">
        <property type="entry name" value="COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="396" mass="44196" checksum="82658EA40974E711" modified="2017-06-07" version="1">MKRINIVGVFPGRPINPEAEKCIMESQVIFSGRRNLELIPQTPAQIFNIGSMKQFTGDLANTLADNKTVTVVASGDPLFFGIGKYITEHYDSGDIYIVPEVSSLQVALSRLGMDASHMVAISLHGREIKGLAQKIRNKRKIAIFTDGNNTPSRIAEYMTSFGLVDYSSYVLERLGYKDESISKYKIKELIGKEFNDLNIMILIKDGNVKISLLDDGVLLRKNNNITKKEIREISVSELDLNNGDTMWDVGSGSGSVAIYASLINPDGNIFAIEKDKALCNFIDENMRKFSTDINIINGEAPEALDGIPDPEAVFIGGSSGNIKNIVKYCYVRLKDGGRMVANITTMENFYAMMNYIKENNLQFDVKQVNISRLKPVSVYTRFEPLDQIYIVKVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2D0</accession>
    <name>A0A1V0N2D0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887410.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2D0"/>
    <dbReference type="GeneID" id="16025555"/>
    <dbReference type="KEGG" id="fai:FAD_0389"/>
    <dbReference type="OrthoDB" id="56524at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="107" mass="11777" checksum="D7CDF180EEFB6ED8" modified="2017-06-07" version="1">MDIQIGKGSIDIGDKAVKLIGNRVLSISILTTQGACTDEMCPLIKTAVCEIKDNFSTGTLYKIQNPVKIEMPQEVYNSIDRERQHIKLKISLKGKPEIKGFSLVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2H4</accession>
    <name>A0A1V0N2H4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0375</name>
        <name evidence="2" type="ORF">HLB00_00775</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000021">
        <property type="protein sequence ID" value="NOL59373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887395.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2H4"/>
    <dbReference type="STRING" id="74969.FAD_0375"/>
    <dbReference type="GeneID" id="16025541"/>
    <dbReference type="GeneID" id="31675884"/>
    <dbReference type="KEGG" id="fai:FAD_0375"/>
    <dbReference type="OrthoDB" id="9014at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="215" mass="24320" checksum="2666FD540E21D412" modified="2017-06-07" version="1">MDTKKYFDLSVELKPNMPCWPTNPIVRIDPIGVLSRDGYSVEKFETVTHTGTHIDAPYHMIDNGMTVDKIPLSQIIGPGYCIRPEVDGTEIKLNALKKIWKPEYDNKIILINTNWDKKRGFTKEFQYDFPGLADDTVDFLIEHHPKVIGIDTLGIDPYSHGDFRVHKALLSKNMVFIEDLANLDKLETGREYTVIALPLKIYGGSGAMARVVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2I3</accession>
    <name>A0A1V0N2I3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2I3"/>
    <dbReference type="STRING" id="74969.FAD_0445"/>
    <dbReference type="KEGG" id="fai:FAD_0445"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="60" mass="7078" checksum="93125F584A5E3FCB" modified="2017-06-07" version="1">MYPDSTGNYIIQLLYVLDLPKHRLMGVYLNKKGKYGIKFPAAFMEILYLLSLKIIHMDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2J2</accession>
    <name>A0A1V0N2J2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0455</name>
        <name evidence="4" type="ORF">HLB00_10030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000442">
        <property type="protein sequence ID" value="NOL61155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887507.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2J2"/>
    <dbReference type="STRING" id="74969.FAD_0455"/>
    <dbReference type="GeneID" id="16025656"/>
    <dbReference type="KEGG" id="fai:FAD_0455"/>
    <dbReference type="OrthoDB" id="28112at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141322">
        <property type="entry name" value="NfeD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD-like C-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL61155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="117" mass="12910" checksum="A597A3AE1F7D737D" modified="2017-06-07" version="1">MFTEIIPVDYTTAVPGSLVFAVILVIIVLVVIITVTVYYLYKIISSQRGRKYTGSESMTNIIGIASNNIDKNAGGFIKIDGVSWEVINNGDEPIEKYDKVVVTGRIGLKLMVKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2M3</accession>
    <name>A0A1V0N2M3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="7">BPG-independent PGAM</shortName>
            <shortName evidence="7">Phosphoglyceromutase</shortName>
            <shortName evidence="7">aPGAM</shortName>
            <ecNumber evidence="7">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">apgM</name>
        <name evidence="10" type="ORF">FAD_0440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141595.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2M3"/>
    <dbReference type="STRING" id="74969.FAD_0440"/>
    <dbReference type="GeneID" id="31675949"/>
    <dbReference type="KEGG" id="fai:FAD_0440"/>
    <dbReference type="OrthoDB" id="52918at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01402_A">
        <property type="entry name" value="ApgM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023665">
        <property type="entry name" value="ApgAM_prokaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003104">
        <property type="entry name" value="PRK04024.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="COFACTOR-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209:SF0">
        <property type="entry name" value="METALLOENZYME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="9">
        <location>
            <begin position="2"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="402" mass="43514" checksum="88B8A7749FE492A6" modified="2017-06-07" version="1">MKKIILIIMDGLGDRPNKELDGLTALQAANRPNLNYLSSHGTTGLMSPVASGIRAGSDTSHLSILGYDPHKYYTGRGPFEALGVGLELKPGDIAFRANYASIIDGKIVDRRAGRIQNTAELSSALETEIDGVKFIVKSGVEHRAAVVMRGPKLSDKVSETDPHSVDSSPMDTEPLAPEANFTSAVINKFLERSRKILASHPLNRKLISEGKLPANEIMLRGVGKMPAIPSFHEKYGMKAACISGTPLIRGIAGLAGFDVLSVEGMNGRVDTNYENIISSAIKSLEKYDFILINFKGTDIAGHDRKPWLKKQVIESVDSVIAPLLKLLQDTLIVVTGDHSTPCSFGDHTGDPVPIMFATDGIINDNVRTFDELSVSDGYYKITSGDIMPIILSYSDRSEKYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2R3</accession>
    <name>A0A1V0N2R3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0472</name>
        <name evidence="4" type="ORF">HLB00_04200</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000144">
        <property type="protein sequence ID" value="NOL60035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887527.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2R3"/>
    <dbReference type="STRING" id="74969.FAD_0472"/>
    <dbReference type="GeneID" id="16025676"/>
    <dbReference type="GeneID" id="31675981"/>
    <dbReference type="KEGG" id="fai:FAD_0472"/>
    <dbReference type="OrthoDB" id="29061at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43129">
        <property type="entry name" value="FOSMIDOMYCIN RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43129:SF1">
        <property type="entry name" value="FOSMIDOMYCIN RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="7"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL60035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="411" mass="44736" checksum="AFC87AB44D0BEF09" modified="2017-06-07" version="1">MKDQGKSLIFTSLGHFANDGNFLLFPTLIAYYKVIPHVSIAFLGVMAIIYNLLSGLLGPSIGKLADRIDRDGALIFLGILLEAISAIFFGLAFVFTAYVNYIILVAAVILGIGQAFYHPIGASILAFTYGKKDSSTAMGINGSFGSLGRALIPSVLVYAIVFFGKFYGLVAVAAYTTIAAVIILGGLSFFKRSKYIKIDTKKHAKNTEESKASESEYKKYGKFLYILTAIVFIRSFFLMGTVTFTPDYFDNIFHSKVIMGDLLTISFLGAVVGQPYFGRVVKDHGGKFTIAVTTIASTVFFGLMLLTDNVYLVTVIYLLYATFAFTSFPVLLGYVAQTIPQKFSTRSNALVWSFGNIVGGAIGIAIVTILLYVHVALYTSLVVMLIFSVISIIMLPLLPSKKKQEELASGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2T6</accession>
    <name>A0A1V0N2T6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9 10">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 15" type="primary">radA</name>
        <name evidence="14" type="ORF">FAD_0550</name>
        <name evidence="15" type="ORF">HLB00_00745</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Berkeley</strain>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9 11">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 11">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000020">
        <property type="protein sequence ID" value="NOL59367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841717.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2T6"/>
    <dbReference type="STRING" id="74969.FAD_0550"/>
    <dbReference type="GeneID" id="16025758"/>
    <dbReference type="GeneID" id="84217150"/>
    <dbReference type="KEGG" id="fai:FAD_0550"/>
    <dbReference type="OrthoDB" id="31129at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19515">
        <property type="entry name" value="archRadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002052">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="12">
        <location>
            <begin position="94"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="13">
        <location>
            <begin position="270"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="NCBIfam" id="TIGR02236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="NOL59367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="331" mass="36153" checksum="9D2214FE8265F548" modified="2017-06-07" version="1">MAKEKKIDDELDSELENKKLTIEDLPGVGEATAEKLRENGYDDIMAIAVASPKDLADISGIAEGAAVKIINAARKYADVGNFETGEEILKRRKEVRKLSTGAQGLDNLIGGGLETQSITEFFGEFGSGKTQIMLQLAVNATMPEEQGGLNSDVLIIDTENTFRPERVIQMAKAKNLDPDETLKRIHVARAYNAHHQILLAEKASDIAKEFPIKLLIVDSLTSHFRSEYVGRGSLAERQQLLNKHMHDLLKFGTIFNAVIAVTNQVSANPAVFFGDPMTPIGGNIVGHTATFRLYLRKAKAGKRIARLIDSPYLPEGEAVITLTEDGIIDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2U5</accession>
    <name>A0A1V0N2U5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS200-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141671.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2U5"/>
    <dbReference type="STRING" id="74969.FAD_0546"/>
    <dbReference type="GeneID" id="31676052"/>
    <dbReference type="KEGG" id="fai:FAD_0546"/>
    <dbReference type="OrthoDB" id="92826at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="entry name" value="Transposase IS200-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033573">
        <property type="entry name" value="transpos_IS200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33360">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33360:SF2">
        <property type="entry name" value="TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="Transposase IS200-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS200-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="133" mass="16020" checksum="D4B5105DBD64D94F" modified="2017-06-07" version="1">MVSERWTRSNKSVYNLGYHIIWCPKYRRNVLVNGIDVRLKELLNYKAQELKIEIKEMEVMPDHIHIFIKADPVLSPHYIIQQFKGYTSRILRQEFPVLKRKLPTLWTRSYYIESVGHISESVVRKYIEDQKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2W5</accession>
    <name>A0A1V0N2W5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0502</name>
        <name evidence="3" type="ORF">HLB00_09600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000426">
        <property type="protein sequence ID" value="NOL61071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887560.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2W5"/>
    <dbReference type="STRING" id="74969.FAD_0502"/>
    <dbReference type="GeneID" id="16025706"/>
    <dbReference type="KEGG" id="fai:FAD_0502"/>
    <dbReference type="OrthoDB" id="24596at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05344">
        <property type="entry name" value="BKR_like_SDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF6">
        <property type="entry name" value="NADPH-DEPENDENT REDUCTASE BACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL61071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="261" mass="28807" checksum="A00EBAA06262E06B" modified="2017-06-07" version="1">MHDLKNKNAIVCAGSTGIGKGVISVLAKYGANITTFSRTKENVESLKEEIRKETGVTVNAMCADLSKKDDLMRVVDSAHEQYGKIDFLVMNYGDPRVDPFMQLNESDWDYNIDMIFKSTIRMVDMCATDMIKSNSGRIIFITSMTTKNPLENFAISNSLRSGVVALGKTLSIELGKYNINVNSISQGYFYTRRLENIIKKNSVSSGKPVEEVESQLMKEIPLGRFGKPEEVGNLVAFLCSGMSSYITGINIPIDGGVIKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2X6</accession>
    <name>A0A1V0N2X6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sterol carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0542</name>
        <name evidence="3" type="ORF">HLB00_02520</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000080">
        <property type="protein sequence ID" value="NOL59708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887598.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2X6"/>
    <dbReference type="STRING" id="74969.FAD_0542"/>
    <dbReference type="GeneID" id="16025747"/>
    <dbReference type="KEGG" id="fai:FAD_0542"/>
    <dbReference type="OrthoDB" id="51304at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="134" mass="15268" checksum="7B23EF7C00A0DBCC" modified="2017-06-07" version="1">MAKFPSDEWAKEYTEKLNSNPAYAEAGKTWDDSLTFVVQPDETYNDSWYLYLNLKAGKCIDSKVGKAESDVPKATFKYMGKYSNWVKLIKGEIDPIQGLMTGKFKLDGSMMKIMRYTNAAKEMVNTAKMVDSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Z1</accession>
    <name>A0A1V0N2Z1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Z1"/>
    <dbReference type="STRING" id="74969.FAD_0619"/>
    <dbReference type="KEGG" id="fai:FAD_0619"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000002">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="6">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="157" mass="17340" checksum="B06D9BD9AF7AD3E8" modified="2017-06-07" version="1">MDEMKTGDLGVKTTTLEKALQWGRSNSLWPLTMGLACCAIEMMATQAADLDMARFGSEIFRNSPRQSDLMIVAGTTTKRMAPRVKRIYEEMPYPKYVIAMGVCVIQGGPYVDGYSVVLGVDKVIPVDVYVPGCPPSPQALTYGLITLQKKIRNETDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Z6</accession>
    <name>A0A1V0N2Z6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0557</name>
        <name evidence="2" type="ORF">HLB00_00715</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000020">
        <property type="protein sequence ID" value="NOL59361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141687.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Z6"/>
    <dbReference type="STRING" id="74969.FAD_0557"/>
    <dbReference type="GeneID" id="84217156"/>
    <dbReference type="KEGG" id="fai:FAD_0557"/>
    <dbReference type="OrthoDB" id="39416at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="92" mass="11113" checksum="3616F480F6EB2B2D" modified="2017-06-07" version="1">MPWIPIRSVDKHVYSMLVKMDNNYMLTIKSFKKDRIVTVKKLEGRFNIIEEGFRNENFTVDEKDLKKIMKEIIELEYPRSHKVMVSEQELHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N308</accession>
    <name>A0A1V0N308_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH dehydrogenase subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887680.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N308"/>
    <dbReference type="STRING" id="74969.FAD_0622"/>
    <dbReference type="GeneID" id="16025829"/>
    <dbReference type="GeneID" id="31676127"/>
    <dbReference type="KEGG" id="fai:FAD_0622"/>
    <dbReference type="OrthoDB" id="15253at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="NADH DEHYDROGENASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432:SF3">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="351" mass="38855" checksum="484BF11427A53DE1" modified="2017-06-07" version="1">MSLLLRIHQWLSFLGYDASFGLAYLIQTIVVIVFVGISFVALIYIFRKYMARIQRRVGPNRVGKFGLLQLIADLFKLLGKESIMPAKRDDLAYKLAPAIVIIGTILAFILLPYGDLAYFGSIAVTHSRVTLILMFGLLSILPIGEILAGISTKSNYALLGTMRGVAKDISFEIPMMISVLAIVMITSRSYVTGTAITGGLSLSGIVSNEVIPYGIIEPLGLLIFYISMVARASMSPFDMGESDSELISGYTTEYSGMRFGLFYVGLFGMVYLTSFIISILYLGGANGPYESYVGFFYLLIKTVILVLIAFVVWVTLPRIRIDRFVNLGWKYLLPLSMANLVYAGLFVLYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N358</accession>
    <name>A0A1V0N358_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase subunit C</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="5">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0620</name>
        <name evidence="5" type="ORF">HLB00_04685</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000162">
        <property type="protein sequence ID" value="NOL60131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141730.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N358"/>
    <dbReference type="STRING" id="74969.FAD_0620"/>
    <dbReference type="GeneID" id="31676125"/>
    <dbReference type="KEGG" id="fai:FAD_0620"/>
    <dbReference type="OrthoDB" id="43567at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004737">
        <property type="entry name" value="PRK06074.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="3">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="151" mass="17750" checksum="A990EC7BE2AD1A7F" modified="2017-06-07" version="1">MYKILSEETDKSGMKVLNIDKSDLVELMEDYKGKGYYLSSITGIDMKDHLEVVYHIHNFDQNDYICVKVATDDEKVPSLVKLWKAADWDEREQYDLMGVIFEGHENLRRILLPEEWVGHPLRKDYDLKKVQYVSMDKSGAEHVSFDEKEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N367</accession>
    <name>A0A1V0N367_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside 2-deoxyribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141799.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N367"/>
    <dbReference type="STRING" id="74969.FAD_0693"/>
    <dbReference type="GeneID" id="31676194"/>
    <dbReference type="KEGG" id="fai:FAD_0693"/>
    <dbReference type="OrthoDB" id="240616at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17399" checksum="997ADCAED0791F38" modified="2017-06-07" version="1">MKSYDFYISAPLFNEMELKFNRELAAFLEKRGFTTYLPQRDGGEDEMLLKDPDLWPETSKRVFNRDVDALKSSSALIMVMDGRVPDEGACVELGMAYAFGKICIGFQTDNRRFASGQNNLMLDYCMSYDIVHDWNDLEVLLRQLKEKINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3A3</accession>
    <name>A0A1V0N3A3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3A3"/>
    <dbReference type="STRING" id="74969.FAD_0670"/>
    <dbReference type="KEGG" id="fai:FAD_0670"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="51" mass="6159" checksum="8ACB854AEE5B62C5" modified="2017-06-07" version="1">MQLYTVFIMRIKKMITISQENYDFLKQHPEIKLSALVENGINEYRTVIKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3D2</accession>
    <name>A0A1V0N3D2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MutS-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141942.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3D2"/>
    <dbReference type="STRING" id="74969.FAD_0766"/>
    <dbReference type="GeneID" id="31676269"/>
    <dbReference type="KEGG" id="fai:FAD_0766"/>
    <dbReference type="OrthoDB" id="25832at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="325"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="504" mass="58614" checksum="079DDBE58B08DB89" modified="2017-06-07" version="1">MEFKSITFSSSINLQELDRNNTIFDDFSLRNIFSGFMGNTRNDELERLLYMPLRNIDDIFYRQEIFKDLENPEIYRIITQFAGTGSQIFYNIKRLKDLYDLQRERWLLDSVYMYSRSIENMLDNMRKAGAKSRGFTGFINYLDAYVASDEFKSLKNDAEQLEEELSSIRYLINIKGVKITVREDRDSEDYASEVKEAFSRFLDEDETIPGYDSTPGFGHVEAAVVELVAKFYPEQFNRLKDFYKRRLNFMDPVISRFLHEIFFYLKYLQYITPLEESGLQFCIPEIKGETDRIYCLEFFDLALAAKLNERKQIPVTNNIIVNRNSSVIIVTGPNNGGKTTFARSFGQLHYLALLGCPVPGKEATILHVDNIFSHFEISENPENNMGRLEEELERLHGILEKATERSLIIINEMLSSTTLKDGIEIGRNIIDKIKKMKSICMYVTFIHELSDLPGVVSYVSQVDRKYPEKRTYKVLPMKSNGMAYAMALARKYNLTYEILKGRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3E9</accession>
    <name>A0A1V0N3E9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141938.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3E9"/>
    <dbReference type="STRING" id="74969.FAD_0764"/>
    <dbReference type="GeneID" id="31676267"/>
    <dbReference type="KEGG" id="fai:FAD_0764"/>
    <dbReference type="OrthoDB" id="28434at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04182">
        <property type="entry name" value="GT_2_like_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43777">
        <property type="entry name" value="MOLYBDENUM COFACTOR CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43777:SF1">
        <property type="entry name" value="MOLYBDENUM COFACTOR CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MobA-like NTP transferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="197" mass="22091" checksum="3664B9EC4AA5AAA6" modified="2017-06-07" version="1">MDKIAAIVLASGKAMRFKSNKLLYEVNSKPIIYYAIDNVARSNFQQRIIVLRSPEISDYSERFGYKVVWNKDYENGMSSSIIHGIENVSPDIEAAMIIPGDMPLLDSNTFNGLIEHFKSSGKGISGFEYNGTIISPVIFARKYFSELKELGGDKGAKSIIVKHYGDFSHMIISGDLLIDIDTMDDALKFKNLIKHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3F5</accession>
    <name>A0A1V0N3F5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="8">CDG synthase</shortName>
            <ecNumber evidence="8">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Archaeosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">queE</name>
        <name evidence="10" type="ORF">FAD_0723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-carbaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="8">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3F5"/>
    <dbReference type="STRING" id="74969.FAD_0723"/>
    <dbReference type="KEGG" id="fai:FAD_0723"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42836">
        <property type="entry name" value="7-CARBOXY-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42836:SF1">
        <property type="entry name" value="7-CARBOXY-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="31"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="229" mass="26457" checksum="3C27E526E2F93683" modified="2017-06-07" version="1">MNWKFINSPYLRFLKMYINEIFLSIQGEGLYSGEKMVFIRTEYCNLRCSWCDTKYSFYEGKEMSIDEIVESARNINSGHGASWICLTGGEPLLQKDISVLVDRLSEEYNILLETSGSLDIGRFLPNHVKVKKDIDFKLPSSGMYRKFNDKNISYMEEGDYIKFVVNDLNDFNVAMEEIEKIGKNVKIVVQPVYGTDIKMLADAFIDKAPSNARLMLQEHKYIYGEIRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3F9</accession>
    <name>A0A1V0N3F9_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">Intracellular proteinase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141950.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3F9"/>
    <dbReference type="STRING" id="74969.FAD_0774"/>
    <dbReference type="GeneID" id="31676275"/>
    <dbReference type="KEGG" id="fai:FAD_0774"/>
    <dbReference type="OrthoDB" id="82036at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd03169">
        <property type="entry name" value="GATase1_PfpI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="DJ-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733:SF2">
        <property type="entry name" value="DJ-1_THIJ_PFPI FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="186" mass="20734" checksum="F0F5860150FD3361" modified="2017-06-07" version="1">MAKILILTGDAGESLEVMYPLQRMKEEGFDMDLAAPEKKKIQLVVHDFEDGFDTYTEKLGYKVQADIAFKDVDPSQYDALIIPGGRAPEYIRNDKDFIRIVQYFFEKNAPVAELCHAPLGLAAAGVLHGRKTAAYPALAPDVTIAGGTFVDAAVVVDGNLISSRAWPDHPQWMREFIKLLHERDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3I0</accession>
    <name>A0A1V0N3I0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3I0"/>
    <dbReference type="KEGG" id="fai:FAD_0741"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.600">
        <property type="entry name" value="Thermoplasma acidophilum protein TA0956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038394">
        <property type="entry name" value="TA0956_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="92" mass="10044" checksum="5AF2F7C2737E7F20" modified="2017-06-07" version="1">MCVPLAELNGSLDDLCANIRKLQGFIDKYGKSAGVNKDDANVGIIIVNPGKKIVDMSFSQNLGIDKMKVNSSAEELRKNKFTVTVHFPSTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3I1</accession>
    <name>A0A1V0N3I1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141906.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3I1"/>
    <dbReference type="STRING" id="74969.FAD_0747"/>
    <dbReference type="GeneID" id="31676250"/>
    <dbReference type="KEGG" id="fai:FAD_0747"/>
    <dbReference type="OrthoDB" id="7236at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="320" mass="35964" checksum="0B64F2E0631BC080" modified="2017-06-07" version="1">MEYTKLGYTDLKVSRLCLGGMSFGSSKWMADPETSGKIIKKAIDYGINFIDTANIYSSGESEKIIGEAITGYRSQLVLSTKGGGKVNDFTQGFSRAILFNEIKNSLKNLRTDYIDIYFLHTIFDNVDFRDTAHTLSSFISSGKAGYIGLSNFMGYQLAEFSTIMEMQENIKPAILQNHYNAVYREDERDAIPFCEKHEIAYSPFSPIAAGFLSGKYKRGLENETVRTKTYPVMKERYFSDSDFDILESVEDIAKKKGVNVPQLALAYVLNKGFIPVIGATKLEYLEDDIAALDIKLGREEMEAIDRNYKPHKIVKGTAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3L8</accession>
    <name>A0A1V0N3L8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphosphomevalonate decarboxylase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141934.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3L8"/>
    <dbReference type="STRING" id="74969.FAD_0762"/>
    <dbReference type="GeneID" id="84217382"/>
    <dbReference type="KEGG" id="fai:FAD_0762"/>
    <dbReference type="OrthoDB" id="56800at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053464">
        <property type="entry name" value="MVD_Decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040847">
        <property type="entry name" value="mev_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="6">
        <location>
            <begin position="43"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="364" mass="41377" checksum="1A9C9812FB57EE92" modified="2017-06-07" version="1">MDFKFEGENIKHKLVDMGLYRELINYDTVLEPGKISTGYSYPIKAFEKFLGYYDNYYKIANNPSTSFNTDFSFVYSACMYTKKDNSDMVILDGKPATGYVDRYEKPLEIFRKNTGIRGSFVFNIKRYRKYSEAKGLSESSAVASAVARSLIKNVFGEMAAKDDSYVSRYARLVSGSGTRAAINGPSIWLSYPGMQEQNSFAVKIPADVDKINYAIFPKNIDYRTSNAHSEAVQSIFYNSWLNEKYNKLNEIIDGGFNIELMMNRAMEDMYALNSVLLSRGNVIQTAESISLLKNFIEFSKKHEGIYITGDTGPSLMVMSADKSLLNQFLETVNDPKIVGSHHPEAHKKRGNEFRKESEEYFQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3N3</accession>
    <name>A0A1V0N3N3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142004.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3N3"/>
    <dbReference type="STRING" id="74969.FAD_0811"/>
    <dbReference type="GeneID" id="31676313"/>
    <dbReference type="KEGG" id="fai:FAD_0811"/>
    <dbReference type="OrthoDB" id="115724at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="451"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="651" mass="74798" checksum="82838E9D33DD4BF3" modified="2017-06-07" version="1">MEEAESILKRDIGFSVKYIDRSKNPAKDFYGYCNGKWLEETTIPEDRSRYGAFDMLYEKNMYILRSILEDLQKNSHNNMEKQLGDFYASAMDTERLEKLKFSPIKGEMDNINNATKEKLPELFAELTMKSVQIPFDIGSAEDAKNAEIYSLYIGQGGLSLPDRDYYLNEQMKPILDAYKKHIARMFTLYGYTQNDAENTAERVVSLETELAKFSRSKTDLRDVERAYNKYSMEELFQKFPELGFDRYFKIIGSGNMNYAIMDAPEFFEQAGALLKNTAIENIVSYLKWKVLAGSAMFLHKEAVDENFNFFKKTLLGQEKIAPRWRTVVNVVDASIGDSLGQVYVDKHFGKEAVEKITVLVNDIKAIFKERLENNPWMSKETREKALLKFSKFNAKIGYTEKFKDYSSIEINPDDYIGNVERAASFELNRQLKRIGTKVDKTEWYMTPPTVNAYFNSMGNEIVFPAGIMQPPFFDPEMDDAVNYGGIGGVISHEITHGYDDQGSHFDENGNMVNWWTDEDKKRFDEMAEKVVKLYSSVEILPGLNVNGKLTLGENIADLGAVLIAYEALQKRLKAEPAKNIKIDGLTPEQRFFISWGQVWRTKIRDNEARRLATIDPHSPGSVRSELPPWNHPDFCKTFGLPSSTKEKILMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3S3</accession>
    <name>A0A1V0N3S3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3S3"/>
    <dbReference type="STRING" id="74969.FAD_0835"/>
    <dbReference type="KEGG" id="fai:FAD_0835"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="191" mass="22283" checksum="CB48423D62E38E51" modified="2017-06-07" version="1">MMKELTLYKIRDMALKNNVSVYNVNEFANLIQKNNKVAIVYMNRLVRNNLATKPVNGKISFINDDFIMASQLIYPSYISTNSALLFHKLAQQVPGKVECVTTINSINYNKLGISYHKIKPELFFGYKRYNYNNSYIFVANPDKAVFDGLYLNIFSENDINEFKNNIDFSDLIRNLKNIKIRKIKKIMEILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3S8</accession>
    <name>A0A1V0N3S8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type III restriction protein res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142058.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3S8"/>
    <dbReference type="STRING" id="74969.FAD_0846"/>
    <dbReference type="GeneID" id="31676346"/>
    <dbReference type="KEGG" id="fai:FAD_0846"/>
    <dbReference type="OrthoDB" id="56011at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120545">
        <property type="term" value="F:nucleic acid conformation isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09203">
        <property type="entry name" value="PLDc_N_DEXD_b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052511">
        <property type="entry name" value="ATP-dep_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962">
        <property type="entry name" value="ATP-DEPENDENT HELICASE LHR-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962:SF7">
        <property type="entry name" value="MITOCHONDRIAL ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="347"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="649" mass="74270" checksum="2E9850DF706EC2B6" modified="2017-06-07" version="1">MLEKGLYEKLINFCLRNELNNNTEIESLEKALVNDQLSRILAAYVGERTKHRLDIMEDKRLPVSDRLDFVNNLLDKINSDGRESTSKEKIHINNPLDKISSKTEQNCDNIESPPKILLSAYPKNNENKKIDLTIRPDTSVAYSSLFTGSSNEPQFYYELQKEIQTSDQVDMLVSFIKWTGLRLIIKKLKEFTDNGGKLRVITTTYMGVTDIKAIEELAKLTNTEIKISYDTKNTRMHAKTYIFLRNTGYSTAYVGSSNLSGAAISSGLEWNLKITKIDMQDVFDKIDATFDSYWSSEAFESFSPDQLARLNKALKNESSINNSGNEYSFDFHPYPYQSKILEELRADRQLRGNYHNLVVSATGTGKTIISAFDYKQFVREHPDSSNRLLFIAHREEILKQSIACFRNVLKDPEFGNLYVGNYKPLSDEHLFMSIQTFESIRPDLQLDKHYYDFIIIDEFHHAAAKSYANLLNHFNPEIMLGLTATPERMDGRDILKYFNNHITSEIRLPEAIDQHLLCPFQYFGITDSVDLENIAWKKGSYDVSELENLYVKNSGARERAKLIIDAVREYSTDIDSMKALGFCVTKAHAKFMAHYFQESGIQSIALTSDSTHQERNDARKKLVFGQLPTAKAVSLQLGCHNGQKNHPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3T3</accession>
    <name>A0A1V0N3T3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3T3"/>
    <dbReference type="STRING" id="74969.FAD_0867"/>
    <dbReference type="KEGG" id="fai:FAD_0867"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="301" mass="35349" checksum="416EBB5AE7D511B5" modified="2017-06-07" version="1">MYNAIFSKNYTKILSERSGVKYINVLQGLGDLSFGNIGKYVYDTIKLSKNYRILLFRIYQYFNRQALKRNIAKQKNLVAVVIINRNYQENFTIQFDNVNVLKIGNGIWNSNIHLIKYTQNVKKNYIIYFARLNYTKGIFEIPIVLKNILKCCNTKLVIVGNFTRETEKYQFIQIVKKYKLEDNIILKGYLTNEQLYDEISKSKLMIYPSHSDSFSLAISQALALHTPVIAYNIAGVKIYENLKAVRLVNEFDYKAMANEAVRILKMKDINRLFDNNLNDFINEHNWNNVAMEYKSIIEKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3T5</accession>
    <name>A0A1V0N3T5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">cas2</name>
        <name evidence="9" type="ORF">FAD_0938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142203.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3T5"/>
    <dbReference type="STRING" id="74969.FAD_0938"/>
    <dbReference type="GeneID" id="31676442"/>
    <dbReference type="KEGG" id="fai:FAD_0938"/>
    <dbReference type="OrthoDB" id="43236at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143430">
        <property type="entry name" value="TTP0101/SSO1404-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="86" mass="10274" checksum="A6E9101667085F74" modified="2017-06-07" version="1">MWIVLTYDINEKRVNSIRKICALYLIRVQNSVFLGEIGWANLRILRDKLKDKIIESEDSIQFFILRDEKLVRRIKLGVSYEFSNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3T8</accession>
    <name>A0A1V0N3T8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_0848</name>
        <name evidence="7" type="ORF">HLB00_09585</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000425">
        <property type="protein sequence ID" value="NOL61068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887969.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3T8"/>
    <dbReference type="STRING" id="74969.FAD_0848"/>
    <dbReference type="GeneID" id="16026079"/>
    <dbReference type="GeneID" id="31676348"/>
    <dbReference type="KEGG" id="fai:FAD_0848"/>
    <dbReference type="OrthoDB" id="57516at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051598">
        <property type="entry name" value="TSUP/Inactive_protease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN MJ0441-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701:SF2">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN YJNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL61068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="252" mass="26819" checksum="42F3A4D39A1D43E8" modified="2017-06-07" version="1">MFYLFYLEFIILGIIVGALTGVLGSSGVVAVVPALIIINSELPQEAIGTSLLIDVITSVMVAYVYFKRGRVNIKKGIPMILGAIIGSQIGVRIAFLIPAESVKIGFAVFIIAMGIYSLIRRKEMQNTKDTQRLLNIKPWEIVLITIPVGLATGILGASGGIMFLIISILILKLDIKTAVGTSTFSMIISASSGTVGYLIAGHIMIIAALIIGSISILSGLIFSRIGNNINPLSTYKILGTVFIIIGIVQIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3U3</accession>
    <name>A0A1V0N3U3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase IS4-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0638</name>
        <name evidence="3" type="ORF">FAD_0880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886499.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3U3"/>
    <dbReference type="GeneID" id="16025848"/>
    <dbReference type="GeneID" id="31676384"/>
    <dbReference type="KEGG" id="fai:FAD_0638"/>
    <dbReference type="KEGG" id="fai:FAD_0880"/>
    <dbReference type="OrthoDB" id="209995at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="90"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="392" mass="44651" checksum="F66C11A893307CC2" modified="2017-06-07" version="1">MIDIPVVDSPDVLNRLLLEFRPLFGRRQFRQFCRYIVSGIASSTRSSAHLNGIFVEHTNQSNLNRFLRNIPADGIFNISCSLINRNCSGPVLSLDDTILQRNGKHIDGAQWIYDHSQGKTVYGMQYTTSVISGNEGIFPLSMELKTDDSKIDLQINTIKKAMGAGLRFSTVVFDSWYFSSKLVKFLESMGKDYVSEAKSNRTVCIDGKWIRLRDYANTLDLKSMKSYTVNGKTYFMKAITTRMKNAGIVKVIVSRRINSLKFFVTNRTDWKVKTIIGKYLRRWDIEVFHEELKQDGLKHLYQRKHATLLGTAKMSLLGELLLEISAINSMGNHLKIRKGTPEPRHKQVAISILTDLFKAIENKGRSFLDAILKSIEEPYRSTRNIYGGAINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Y5</accession>
    <name>A0A1V0N3Y5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ORF">FAD_0905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142159.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Y5"/>
    <dbReference type="STRING" id="74969.FAD_0905"/>
    <dbReference type="GeneID" id="31676408"/>
    <dbReference type="KEGG" id="fai:FAD_0905"/>
    <dbReference type="OrthoDB" id="57189at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001943">
        <property type="entry name" value="PRK00724.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="FORMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592:SF1">
        <property type="entry name" value="SULFUR CARRIER PROTEIN FDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="272" mass="30172" checksum="FE36CFA8A0460D91" modified="2017-06-07" version="1">MSGYIKRKIIHSVSGSREQTYDNVTVEEPLEIRIYHENETYNVSVIMRTPVDDFALAAGFLFTEGIIKPENIIDIKYSTDAGISEKDNIVIVSVNSFQKQLIGNRNFYVNSSCGVCGKTNINDIFLKTGHLISQRNKLHYNQLLELPQIMKNNQEIFKNTGGVHAAAIIDYSGNILSMGEDVGRHNAVDKAIGKMVLKGIHRSPEAVLQVSGRAGFEIVQKAAMYGIPVVSSVSAPSSLAVELADEFNMTLVSFVRGRSFNIYTHPERISMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N410</accession>
    <name>A0A1V0N410_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N410"/>
    <dbReference type="KEGG" id="fai:FAD_0932"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="170" mass="20354" checksum="04854E94496CA842" modified="2017-06-07" version="1">MIHYSDLNKPLVLSAIYTQIAYCEIAIREYLKCKNKYGNNEEELKNFLESMKIKVPCIEKHIRDAIKRFDCNKKNNIETNVLDELHFYDELILFRELISMLSDDQIIKFKENVNLDGNKITLYKNLRNYIMHSKKQIIKKKIYDITKWVDFLKTCQNIISYVETCLNSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N428</accession>
    <name>A0A1V0N428_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malA</name>
        <name evidence="8" type="ORF">FAD_1031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N428"/>
    <dbReference type="STRING" id="74969.FAD_1031"/>
    <dbReference type="KEGG" id="fai:FAD_1031"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06604">
        <property type="entry name" value="GH31_glucosidase_II_MalA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF120">
        <property type="entry name" value="HETEROGLYCAN GLUCOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="166"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="493"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="618" mass="72483" checksum="55BA20584FAA260C" modified="2017-06-07" version="1">MMPAIKTLKGDNYTKIIINNDEPLINFNSDDLKESNNTIFDISCEDQYIILKKKLTQNEKIVGLGEKAYSVLKNRHKFTMYNSDPNGYKRYDDPLYLSIPFLISISENISGIFINSVSKIDIDIGIKEYDKLTIKIYNKSCEIYIFESNNFDDLYKKFTGLIGKTFMPPLWAIKHQISRYSYYPEEEVYSIIDNYKKYIDVSAIYLDIDYMDKFKIFTFDKNKFPDNKRLLDNLHKRDVKLVTIIDPGVKISQDYNVFKNGLGHYIENKNGEIYTSNLWPGNSAMPDFFNQDAIKWWKGEIKHFMKNTDGIWLDMNEPSLFNEFKTIQPDALHNIDNKKIEHRYLHNAYSYFQVKATYEAMKEIKDDVFIVSRSGYAGIEKYAAVWTGDNTSSEDDLKLQISMVVSLNLSGVSVCGCDLGGFMGESSPELISKYYKMALLFPFYRNHKDKFSNDQEIFKLPEFYRDQIVESINKRYELIDYIYSIIYESHLYGFPVIKPLFYYDFNDMNAYYIDDEYIIGNLLYAPQIYGNERQLYIPSGSWLNINNSSIISGNQYIKSDEKYPLYLRKNSMLLIKNKLIVFGKSKMILFKNNKEINIEFDGKELKSSIALDYEVVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N448</accession>
    <name>A0A1V0N448_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142273.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N448"/>
    <dbReference type="GeneID" id="31676477"/>
    <dbReference type="KEGG" id="fai:FAD_0978"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="323" mass="36533" checksum="1C39E899C31842BD" modified="2017-06-07" version="1">MAKIVSNFKYVMFLIATGLFVGVFTFLILSLPGIYRDTVSVFILPPAIAAIFTLISFTSARKLRMSGKRLARSLGLFFIMAYIMLESIFVIITFHTIEALLLLIPADLVLMSIPLFILFSRGKKQDGLEFNTDLTSRLQSMVGTNSPEVYTKAGVGLMFGGSTDAEPWKIIIYKHALESLNDEELDMLMLEIYYKKLLKTGRKTVNFAFSLVTFLFDAYIALYVVDMNVAPVFTPYFIGAELGLFIVILLIPLIFSHVAMKGNIAVDKQILSHNGNRMALISLINRENDREPATMMTQRQYDRFKAKQKMNAKKRIENLDIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N469</accession>
    <name>A0A1V0N469_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142425.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N469"/>
    <dbReference type="STRING" id="74969.FAD_1059"/>
    <dbReference type="GeneID" id="31676558"/>
    <dbReference type="KEGG" id="fai:FAD_1059"/>
    <dbReference type="OrthoDB" id="38993at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43211:SF1">
        <property type="entry name" value="BLL6422 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43211">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="1">
        <location>
            <begin position="75"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="295" mass="33800" checksum="A02125DDBE4C40CC" modified="2017-06-07" version="1">MKICLIEYSGSYRYCIYQEGKYYEMAPMLNMQEDELVREFYNLYDKIINLKLDDKYAIKPDTVKYGVPIPGMRSVRDFYAFEDHVKNARKNKGLDMIKEWYDFPVFYFSCTPNVYPSGYKIKYPEKSKAFDYEMEVAAVIGNRTIDCHENCMDAIFGFITMNDWSLRDIQKEEMKVMLGPAKGKDYATSFGPFLVTKDEILSESEGGKINIDLKGYVNGKLYSHNNLKNIYFSFSELLERASESVPLLPGDVIGSGTFGTGCILELGSEKYGWLKPGDEVSLESPQLGNLVNRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N488</accession>
    <name>A0A1V0N488_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142348.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N488"/>
    <dbReference type="STRING" id="74969.FAD_1018"/>
    <dbReference type="GeneID" id="31676517"/>
    <dbReference type="KEGG" id="fai:FAD_1018"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="323" mass="36383" checksum="D8BE6843BFD2C414" modified="2017-06-07" version="1">MASKKFNIPVSAFSSVMGMEISSIAFHFHRLAAISGFLEYLGVIVYVFLVLYFVFMVLHRKKILKNKTMAPASFTFAAGSSVLGSRLYMGGFIFFSKILLLIAIIFIIYLGFLLLAKTIRKKEIPEIYFMFMPFIGVLSLSNLFTHLHGAFNPAISIWVPVSLFVIGNLSWIITVLSFINYRKYFNYKSLNGFYMIYAGISSLTTVSGTLIIENYGLYGNSLYVLIHWIVTVDYAYSVGLSVFLILFFILKIIKNNIDLNYKISIWGAVFPFGVLSSATYLTGEYNHINILSTLSLFYVSVALSLIIIAIIQIIIFLGKGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N498</accession>
    <name>A0A1V0N498_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gamma-aminobutyraldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142447.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N498"/>
    <dbReference type="STRING" id="74969.FAD_1072"/>
    <dbReference type="GeneID" id="84217672"/>
    <dbReference type="KEGG" id="fai:FAD_1072"/>
    <dbReference type="OrthoDB" id="6342at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="497" mass="54787" checksum="141297CDF4229007" modified="2017-06-07" version="1">METYKMFINGEWVESSGKQVLKVLNPSTGLAVASVQSASRDDVRKAIESARKSFDSGAWSRATPGDRSNVLLKVADLIEQNQDKFIKVETENSGKSIKQISGYDIPYTIDNIRFLAGACRILEGKAMNEYVADGTSAIRREPIGAIGIITPWNYPLMMVVWRAFPALAMGNSVVVKPASYTPLTTLMLADIMKEAGIPDGVFNVITGPGSSVGEEMAKSEKLDMIAFTGSTEVGKRLSVLAASNLKKVSLELGGKAPFIVFKDANIDAAVESAIVGGLVNNGQDCANSTRYYIQEEVFEKFVSRLKNRIQKLRIGDPMDPATDMGPLISETQRERVEGYIEKGIKEGGKLLSGGERPEIPGHEKGYYINPALIYTENEDSAIVKEEIFGPVFTILKFKDYNDAIRRSNDVTYGLGSSVWTSDITTAIRATRDLRFGTVWVNEHVVVPSEMPWAGYKESGHGASLSPYSLEEFTYIKHVYFDLTGKVRKDWYDQIFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4A4</accession>
    <name>A0A1V0N4A4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1090</name>
        <name evidence="2" type="ORF">HLB00_00860</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000025">
        <property type="protein sequence ID" value="NOL59389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886195.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4A4"/>
    <dbReference type="STRING" id="74969.FAD_1090"/>
    <dbReference type="GeneID" id="16024320"/>
    <dbReference type="KEGG" id="fai:FAD_1090"/>
    <dbReference type="OrthoDB" id="9623at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600:SF2">
        <property type="entry name" value="SLL0088 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="219" mass="25116" checksum="8E405ACC45E45200" modified="2017-06-07" version="1">MEVIVNDYLGNSKSTILSSLLYDDKTLDQLSEIMGINKNAVQEHIYYLETHNLVSSYFVRAKTGRPKKYYKLTKNGMQIFPKQYINFSSMLLKEVERELGTVGLNKILMRMAEDIIKEVTSDNMSLTSLNREEKLEKIGEYVNILNKLGYYAKMEVDHDTVKIIRHNCIFYELAKNNKDMVCGSLEGSMLPNTSNEGFKLIENFPDGDNKCVVEITLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4B1</accession>
    <name>A0A1V0N4B1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1101</name>
        <name evidence="7" type="ORF">HLB00_00910</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000025">
        <property type="protein sequence ID" value="NOL59399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886205.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4B1"/>
    <dbReference type="STRING" id="74969.FAD_1101"/>
    <dbReference type="GeneID" id="16024330"/>
    <dbReference type="KEGG" id="fai:FAD_1101"/>
    <dbReference type="OrthoDB" id="197151at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051453">
        <property type="entry name" value="MBL_Glyoxalase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46233">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE GLOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46233:SF3">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE GLOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="204" mass="22265" checksum="BF0E51A41282E54C" modified="2017-06-07" version="1">MKISDSIEKIDGAMANSYLIMIDGMNIIVDAGTPGSGKKITGYLEDHKIKLDAILITHYHVDHVGGLSRIYEKYHPEIFVPANELSIISGSEPVPPKPFLPKFASTIMRARKVKDLKPSSDMNISGIELVKTPGHTRDSTSYYLKEQKVVFSGDAAVNLKGVPGYNKGFAANPENAEKSLKAIRTMDALILPGHGDKMDLRTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4B5</accession>
    <name>A0A1V0N4B5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polysaccharide family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940553.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4B5"/>
    <dbReference type="STRING" id="74969.FAD_1064"/>
    <dbReference type="GeneID" id="84217663"/>
    <dbReference type="KEGG" id="fai:FAD_1064"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050833">
        <property type="entry name" value="Poly_Biosynth_Transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30250:SF11">
        <property type="entry name" value="O-ANTIGEN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30250">
        <property type="entry name" value="PST FAMILY PREDICTED COLANIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13440">
        <property type="entry name" value="Polysacc_synt_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
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            <end position="244"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        <source>
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            <dbReference type="EMBL" id="ARD84945.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="523" mass="58804" checksum="7CA2E57780715014" modified="2017-06-07" version="1">MGNITESFSSGVTFQYSAVASMFISSSLFYFFIAHLLPVSVVGSISLLYAIMNIMAVVFVFGLSNGVQHYLSYHLVRENHGAVMKLMKQTISFSIILALAAFSFMYFSAGEIAILFFHSSAYVLSIKLIGIAIAGSVMINVSGSMLLGLNQYKKYSLIYIFINIFTYFFPLSMLFITGKSVYLIAGLATINIISALLFMIFVYKVYNRLSGLQTKAVKEPYRNLVYYSIPLFFSSIMGTSATYIDRIVVSYFINLSYLGIYNFALIIASAATFLVVPVSNLLIPKLSSFFSLDNKEGFRKSIRILLNIVSLIYIPAALGIAALSRIILYEFAGSDYTIAYIPLIIIMFITSIFIGTTVLASGISSIRKTRIFLYSSGFALASNIILSVILIPRFNIIGAAIAYSSMNAVNFSIVYYYARKFSVNNYDISRVIKIWISAIIMFGIIFTIQGLFPYTMINIFIYILAGLLIYLVEIKVFHLISQEEMGYIISVIPERFSTLRYMAKRMAYNEQKGNYDRLFRFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4B7</accession>
    <name>A0A1V0N4B7_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">FAD_1048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4B7"/>
    <dbReference type="STRING" id="74969.FAD_1048"/>
    <dbReference type="GeneID" id="16024266"/>
    <dbReference type="KEGG" id="fai:FAD_1048"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23528">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23528:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="45"/>
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        <location>
            <begin position="8"/>
            <end position="405"/>
        </location>
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            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="405" mass="44715" checksum="DA67D0C8BD183D53" modified="2017-06-07" version="1">MVNIPKSTSYLLKMNAIHLGTNYLWISYESYILPIELLSYNKSSLFLGIIAFIGTALGVFIGLFFGTLSDKYNFGWGRRGPYIMAGAIFIVLSMFLNQLLTITLAGVLLGYIMIQISSNVAVGAYQPLYADILGEDQRGKGSGIGGIFRLLGSMMGYGITGFLIDTPYRQYVIVLITVVVVVTALLSTNTIKKSDLIIKRKKPGITKLFMDMFNLKNGLKNYIYVVVGSFMVFSGVIGLSFFELYFFKYILHYANPAYYVSIAGIVVLITSAFASFVFGVLSDKIGRKKILVYITVIGGIAMILIPEFEKFVYFLILGSIIGMSYGIFMSVSDALASDMAPGEETGKYMGYYNMATGGASSVSPLIYGLILYFSSSYSLGFRYVFYAAGGFFFIGFAMFYKILKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4E7</accession>
    <name>A0A1V0N4E7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">proS</name>
        <name evidence="10" type="ORF">FAD_1136</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4E7"/>
    <dbReference type="STRING" id="74969.FAD_1136"/>
    <dbReference type="KEGG" id="fai:FAD_1136"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000037">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="43"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD85012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="470" mass="54447" checksum="3EC88B4C1CFEFFF2" modified="2017-06-07" version="1">MVKDKCQMENKKIDFSEWYNEIIDIAKLSDKRYNIKGMNVWLPYGLKIIHSIDSLLREYSDDGGIEEVSFPVLISREQLEVEFEHVKGFENEIYWVTKGGTTPLDIDLALRPTSEAAMYTMFPLWIRSHTDLPFRIYQIVNVYRYETKHTRSFIRVREIHFYEAHTAHVDFEDAEKQMDEYLKIMERLSDDLCIYFSMDVRPDWDKFPGAMYSVAFDTPMPGYRSLQIGTIHEYGENFAKNYGIKYLDENGDMKYVSQTTFGLSERLMAAVIGIHGDDKGLVLPYKLAPVQVIIVPIPSDNYDEIIEYSNGIKSKLMEIGIRCQIDNSDYTPGYKFNEWEMRGVPVRIEIGKREVNDKTLTISLRTRKKKIKIELEEISNMYQYLKEVNFDIKSKASEFYMANKIFIDSLEKIKEDKMVTAYWCGSKACSDEIESLSEKAALGAVRNDNTSGPCIVCGSPGKLSAFSRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4F2</accession>
    <name>A0A1V0N4F2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886220.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4F2"/>
    <dbReference type="STRING" id="74969.FAD_1115"/>
    <dbReference type="GeneID" id="16024345"/>
    <dbReference type="KEGG" id="fai:FAD_1115"/>
    <dbReference type="OrthoDB" id="57329at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14862">
        <property type="entry name" value="Fe-ADH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="181"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="373" mass="41431" checksum="FBEC490EDB219F52" modified="2017-06-07" version="1">MWFFRSPQIIFGDESLGFLESLSIKRAVIVSDKNIRKAGIVDLVIKNLHGTELLIIDDIPEEPEYRAIAKHLDEINQFKPDYFISVGGGSVIDSSKILFFKYERPDLEFYDVTPLVKLNLRQKSKLISIPTTSGTGSECTWAAVISDEMENRKDELASPEIMPDYAILDPQMVKSLPKTQTINTATDAITHAIEGYTSRWNNPYSDAMAEKAIELIIPSIVKLVKDPENLELRNNVHIGASMAGLSFSNSQIGLAHALGHSLGAMFHVAHGKSVGIFLPGVIKFNYAAAGEKYQRLNLLIPEMYRGKTLYESIVIILKALGQTIRISETGIDEKAFRNNLDKLVSLASESTGIVTNPADASRDDITRLFLDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4F8</accession>
    <name>A0A1V0N4F8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Daunorubicin resistance ATP-binding protein DrrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4F8"/>
    <dbReference type="STRING" id="74969.FAD_1142"/>
    <dbReference type="KEGG" id="fai:FAD_1142"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051784">
        <property type="entry name" value="Nod_factor_ABC_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229:SF3">
        <property type="entry name" value="ABC-TYPE MULTIDRUG TRANSPORT SYSTEM, PERMEASE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="6">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="232" mass="25719" checksum="C7966A805354EE65" modified="2017-06-07" version="1">MAWYYGIKTIFRGPSYLIASLATPLTLLFLVFVLSHGALVKFAIVGGLIAFVGSVGLSGAGDSAFFRLQLRIQDLYVPSKVSPFDYMAAFTLSYLVFSVPGIILYIYLGLSYHLFNLYDSSMMLLVMVLLIISTTSISFIISGSIKHLRNIWGITGILTIITSILPPTFYPYSYVPKSFLYIIALSPTTPAAVIAQGAFGLSVPMNSMFYIMIIETVIYTILARILVRWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4I7</accession>
    <name>A0A1V0N4I7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142529.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4I7"/>
    <dbReference type="STRING" id="74969.FAD_1145"/>
    <dbReference type="GeneID" id="84217742"/>
    <dbReference type="KEGG" id="fai:FAD_1145"/>
    <dbReference type="OrthoDB" id="183046at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="483" mass="53294" checksum="206140AE44D6D469" modified="2017-06-07" version="1">MKYNVATSHPLSTMAGMEALERGGNAYDAMLASSSALVVVQPHFNGLGGDLFATIKDNGYYCINASGYAASAASIDFYSRNGYQEIPKRGSLSSFSIPGLVASWKIAAEKSVMGIGENFKRAIQFAKDGFEPSRKLVRAINRFDGGDEDFNNIYKGTDSWLVQKSLGNTLETLVTEGLDSFYNGNIADKIEADMKEKGGLITKKDLLDYKASITEPVRVNYRGYNVYTNPPVSQGLTASVWLRDLNAYDLAGMEHQEYYDTLIKTMHDAYNIRRKYVYDGVKLPENIDDMKPDNDQPGNQKSNLSDTTAYSIFDGEIEISAIQSNYMGFGSGHSIKGTGINMNNRGSYFSLDSENKNSLKPGKKTFHTLMSILASGKKDIILGTMGGDVQPQVNVQILSRIIDLGGNMPDAIAYPRFAYPASIYGDSKVYYESTLRLNHYEPVDDLNDMMGHAQGILIDSDSEAGVDPRGDGLLHYMKEKYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4I8</accession>
    <name>A0A1V0N4I8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142523.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4I8"/>
    <dbReference type="GeneID" id="31676637"/>
    <dbReference type="KEGG" id="fai:FAD_1139"/>
    <dbReference type="OrthoDB" id="57238at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="101" mass="11722" checksum="4937387BEDEA4F6F" modified="2017-06-07" version="1">MEPFLFKSYDKILGIACDIESLITELQCVSNYDYDAASYHIINGHISMWLNYMGFPELAENLKTARSPDEAIRILKSSQRWKTRSPEHAGKHQRNMKQKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4J0</accession>
    <name>A0A1V0N4J0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4J0"/>
    <dbReference type="STRING" id="74969.FAD_1167"/>
    <dbReference type="KEGG" id="fai:FAD_1167"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="70" mass="7827" checksum="10BEB08D236B917A" modified="2017-06-07" version="1">MNIVDRKKDMITAGGYNIYPEEVEKILYEHSGVSQCAVVVVPDAHRGETVKAIIVLSDKSVTEDEIKKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4J3</accession>
    <name>A0A1V0N4J3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142562.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4J3"/>
    <dbReference type="STRING" id="74969.FAD_1184"/>
    <dbReference type="GeneID" id="84217779"/>
    <dbReference type="KEGG" id="fai:FAD_1184"/>
    <dbReference type="OrthoDB" id="372052at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022427">
        <property type="entry name" value="MJ0570_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03679">
        <property type="entry name" value="arCOG00187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="209" mass="23542" checksum="1A2702020A5C8BB5" modified="2017-06-07" version="1">MKAVALFSGGKDSFLSAMMAVEQGYEIIYGVTVVPEEYSMMFHYPNSKISEYAASLLGFSIKYINEKDYRSYLGEICRNGIDAIITGAIASDYQKTRIERACYDTDTIIYSPLWRKNQEYIIDQLILRDIRAMIVSVSAEGLGEGDLGATIDRDYFQHLKYINGKYGINIAGEGGEYETFVYGLGNMEIHGLKKEKIWKNSGGYMILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4L7</accession>
    <name>A0A1V0N4L7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142611.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4L7"/>
    <dbReference type="STRING" id="74969.FAD_1209"/>
    <dbReference type="GeneID" id="84217804"/>
    <dbReference type="KEGG" id="fai:FAD_1209"/>
    <dbReference type="OrthoDB" id="57337at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="187" mass="22309" checksum="EDB5ED8818211A39" modified="2017-06-07" version="1">MSYILFPKNIQVKDNTSIYIDRKTVKDEESFSLLIPEKKSDMVIQYLKIHRGFANATPSFDHGEDYGISKIIKAPWELHIRLYNDSYFPGYSKMMAHIEIARKYLQHLNFEYVQPVIYEPYRYYKSVFGEFILAYKSRYMVENINENYWFRLLNPELLIPWSPAALVKTSFNIVSEKIKDYFDKGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4N6</accession>
    <name>A0A1V0N4N6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886330.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4N6"/>
    <dbReference type="STRING" id="74969.FAD_1227"/>
    <dbReference type="GeneID" id="16024455"/>
    <dbReference type="KEGG" id="fai:FAD_1227"/>
    <dbReference type="OrthoDB" id="30795at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09124">
        <property type="entry name" value="PLDc_like_TrmB_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159071">
        <property type="entry name" value="TrmB C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription regulator TrmB C-terminal" evidence="3">
        <location>
            <begin position="111"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="342" mass="39556" checksum="EF5408CA37676239" modified="2017-06-07" version="1">MTGDELFSKLSKFGLSPYEIKVYKTLLLNGPQTSTSIVSTAGVPQPRVYDLFNNLLNKGLIEISPGKKKIYRAVPVDIALNKIIEDMTAYKDELTEYVKVSEPEMTKYNPYLWYLDNTNLIREQMKNMVINAETEIILSLRLPLLKYLDRYILDAADRGISVILTIFPDSDRYDISELVNRVVIKRRPGISPEIMIKDRDEAIVYVDNVSARAKYALDFQEQEMIHIINYYYYNIVWKPSIYISKFQIRQKWEFKTSWISCEAINVFMNNGYKLTGRVIGETQNGEIDISGNVKGTDVIPGYKNSFLIETDERVFTVGGRLTRIEDIRLEKFQLTAEKNNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4Q0</accession>
    <name>A0A1V0N4Q0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta fold family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. ABHD14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143171.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4Q0"/>
    <dbReference type="STRING" id="74969.FAD_1232"/>
    <dbReference type="GeneID" id="84217828"/>
    <dbReference type="KEGG" id="fai:FAD_1232"/>
    <dbReference type="OrthoDB" id="135859at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197">
        <property type="entry name" value="PROTEIN ABHD14B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="194" mass="21588" checksum="C22D856C61C78E15" modified="2017-06-07" version="1">MLEDKFVNINDAKIHYIEDGKGLPFIFCHGARFNARTYEETETIQAVVDSGFHAISLDFPGYGKSENLSIDMYTFISTFIDTLKLEPVVILGASMGGEAVTGFATKHPEKVKALILVGAVGISDFEPDLSKLEGKPMLLIWGKNDAISVPGNYEMLMRYNPSAEFSNIGRQHACYLDDSKGFNDRIVEFLHKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4T3</accession>
    <name>A0A1V0N4T3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-6x reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_1282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142753.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4T3"/>
    <dbReference type="STRING" id="74969.FAD_1282"/>
    <dbReference type="GeneID" id="84217877"/>
    <dbReference type="KEGG" id="fai:FAD_1282"/>
    <dbReference type="OrthoDB" id="6027at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="COBALT-PRECORRIN-6A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925:SF1">
        <property type="entry name" value="COBALT-PRECORRIN-6A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="250" mass="27729" checksum="110164B32D7AD682" modified="2017-06-07" version="1">MILLLDGTSDSRKLGSELVSDGYSIIATATTEEGAEKLKKENIQAIQGKLDYETIISKCRELYINAIIDGSHPYADAMHENAINASIKLGIPLIRFEREMVKIKSNRIIYADNYEKAVALAGKIGKNIFVTTGVRNIANYKGLLESHNVYFRVLPDPDGIKALIDMGVRRASIVAMEGNFTESLDRAIMEYYGIDTVITKDSGFNAEPKILAALSLGINIIIISRKNYSWENTGHTTLEITKILNHYGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4T7</accession>
    <name>A0A1V0N4T7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiD</name>
        <name evidence="6" type="ORF">FAD_1284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142757.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4T7"/>
    <dbReference type="STRING" id="74969.FAD_1284"/>
    <dbReference type="GeneID" id="31676782"/>
    <dbReference type="KEGG" id="fai:FAD_1284"/>
    <dbReference type="OrthoDB" id="57543at2157"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043780">
        <property type="term" value="F:cobalt-precorrin-5B C1-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019251">
        <property type="term" value="P:anaerobic cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="entry name" value="CbiD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000849">
        <property type="entry name" value="PRK00075.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="COBALT-PRECORRIN-5B C(1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863:SF1">
        <property type="entry name" value="COBALT-PRECORRIN-5B C(1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="CbiD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="354" mass="38469" checksum="F969E989B86779EB" modified="2017-06-07" version="1">MYIENPDRTNLRYGYTTGACATAATRAALIMMVTGKTVDYVEINLPAKKTARFLIENPEIYENYCIASVKKDGGDDPDVTTGLYIYSRVEYSEKPGIEITGGNGVGVVTKEGLPIKPGNPAINPVPLKMLRAAATEVLESYGIRHGLKITISVPGGAEVAKKTCNPKLGILGGISILGTRGIVIPFSDSSWKASIVLGIRVASRLGMDTLVFSTGGRSDTAVHKIFQDFKEEQFIEIGDFLGFSVKRAVDTGIRNLIIAGMPGKISKLADNNMDLHSSKSSVNFDFLASIGKKIGYPDEIISRISHANTVLNVMEIINYDSIFLDAIKERSIENINQITGNKIKVDIEIIKNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4V6</accession>
    <name>A0A1V0N4V6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1300</name>
        <name evidence="3" type="ORF">HLB00_02390</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000073">
        <property type="protein sequence ID" value="NOL59683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841382.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4V6"/>
    <dbReference type="STRING" id="74969.FAD_1300"/>
    <dbReference type="GeneID" id="16024528"/>
    <dbReference type="KEGG" id="fai:FAD_1300"/>
    <dbReference type="OrthoDB" id="30795at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09124">
        <property type="entry name" value="PLDc_like_TrmB_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="237" mass="26660" checksum="5597D97BAD5AE6F8" modified="2017-06-07" version="1">MEANPEHIMKTANMLKILGLSSYEAQAFASLVYHGVANADTIADTAGIPRTSAYKVMESLVSRGFARETEGRPRMFKPEDMGKIRENFINSVNKLFDDLRELQDVLPSKGDPQLVFTIYGRSKVMNKMAEMFDLTEREILIATPRIREIRSELKKNIDNALKRGVKVVFITPPNKRVPHNTEVHRKEGLIATDVASDDSRAMLAGADLDACGYTDNPILSLHVLQFINMMMNDEVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N508</accession>
    <name>A0A1V0N508_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886414.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N508"/>
    <dbReference type="STRING" id="74969.FAD_1313"/>
    <dbReference type="GeneID" id="16024539"/>
    <dbReference type="GeneID" id="31676806"/>
    <dbReference type="KEGG" id="fai:FAD_1313"/>
    <dbReference type="OrthoDB" id="387595at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="277" mass="30574" checksum="390042619365B048" modified="2017-06-07" version="1">MSGNSYYNENSRERLNSISRLLLLISIGFFIAASLINTIYTLTTHHSGLFKVGDIIVIIFDIFYAAIILSIYSSGKFDITDRFIFMSLILFSLIFISELLLSISIGSTIIPAILGFVSLAFGYLYYFFKDDELISRIMIIIAAMLAYIGLIGYPLAPYIFVFGTSYLNSALWAQAFIVMEILLILGFIFKPSAMISDFLTSSAKPLAIFIFGIGLIITGASMVSYNVVALPAALGDSISGVLIIAGILALITGILFVIQSIMKFYDSVIKPRIHFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N519</accession>
    <name>A0A1V0N519_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142855.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N519"/>
    <dbReference type="GeneID" id="31676853"/>
    <dbReference type="KEGG" id="fai:FAD_1361"/>
    <dbReference type="OrthoDB" id="11397at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="176"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="236" mass="28002" checksum="49D65D9918600B90" modified="2017-06-07" version="1">MGVPEDIPFSDFGRLESIKKQNNRLLFDNDLSGFKGKKVYQYIFLYWISDDSIIYNGKKIAKISVNGNLLQRKVLFRQNVFEKFGDTTWTFGLSDKINNGIILCYYHNNEGQKSFAHIFTSKSLKRKIVKKIIETLTEAAEKYGMPIKEGYVFYEYIDKENYKESPPQQEEEGDEKLFKILEIEPTDNPEIIKNAYRKMAKIYHPDLTTPENEEEYSEKMKNINYAYEKLYKKYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N521</accession>
    <name>A0A1V0N521_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dinitrogenase iron-molybdenum cofactor biosynthesis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142865.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N521"/>
    <dbReference type="STRING" id="74969.FAD_1377"/>
    <dbReference type="GeneID" id="31676869"/>
    <dbReference type="KEGG" id="fai:FAD_1377"/>
    <dbReference type="OrthoDB" id="25911at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="entry name" value="Dinitrogenase iron-molybdenum cofactor biosynthesis domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="Nitrogenase accessory factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dinitrogenase iron-molybdenum cofactor biosynthesis" evidence="1">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="125" mass="13812" checksum="0FDAB924012FE3ED" modified="2017-06-07" version="1">MTNKVGIPVNGSNVSGPGEGTEIHIFEVENTKYKLVESYENPAIKATSTRGIHMLKSVLSKNVNAIIVSEIGAPGVNFLKNKIKIYYANNMNENEAMEFYINSKLEEITVATHESPHHDGNTHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N532</accession>
    <name>A0A1V0N532_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anaerobic glycerol-3-phosphate dehydrogenase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142869.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N532"/>
    <dbReference type="STRING" id="74969.FAD_1381"/>
    <dbReference type="GeneID" id="31676873"/>
    <dbReference type="KEGG" id="fai:FAD_1381"/>
    <dbReference type="OrthoDB" id="36306at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="418" mass="46823" checksum="BE46B520560CD62A" modified="2017-06-07" version="1">MEKIGVIGAGITGLFSALNLALDGYDVTLFDREYILSGTSGKFHGMLHSGSRYSVNDMESAKECIRENTLLSNTASLFIKNTGGYYLALNGAEAEYGDKLLQKNKENGISTEELGIDEMLDLEPNINKNILRAFRVPDKVIYAHPFAAAVAVEAQLMGAKLRFKSEVLKAEVKGKTVESIKYRSHNRIVDEKFDYIINTTGPWSGQLLKSFGIGDFEVMPTLGYMASYDYLFSHGILNRMREPSDGDILLPYGSMSVAGTVAIISDNVNNNDIDPEDLDTMLSEVAEMVPSLSRHRYKKLYSSMRPLIREDYSRATRDFRIYENMNNLFSIIGGKFTTSRLMGQAVSQKLSEITGTHSQDTSKIILNDTFDKFIEKHKQDLNTTFMNYISSYGTSMDYGYLTQLESAFIFNEAIRLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N546</accession>
    <name>A0A1V0N546_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN-domain RNase, VapC-type toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142844.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N546"/>
    <dbReference type="GeneID" id="31676846"/>
    <dbReference type="KEGG" id="fai:FAD_1354"/>
    <dbReference type="OrthoDB" id="114910at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052106">
        <property type="entry name" value="PINc/VapC_TA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38826">
        <property type="entry name" value="RIBONUCLEASE VAPC13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38826:SF5">
        <property type="entry name" value="RIBONUCLEASE VAPC13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="136" mass="15227" checksum="B4BD8DFA9853DB51" modified="2017-06-07" version="1">MIYIDSNVFIFAALNNEELGNSAKLILEKVENRSIEASTSSLTFDEVVWIVKKNRSFEDAVSIGEAFLGMEGLHLIDVNQDLLALAISIMKKYKTYPRDSIHAATAITQKAAVVVSEDSDFDKITEIKRIGIREFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N572</accession>
    <name>A0A1V0N572_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886503.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N572"/>
    <dbReference type="GeneID" id="16024629"/>
    <dbReference type="GeneID" id="31676882"/>
    <dbReference type="KEGG" id="fai:FAD_1390"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="332" mass="36514" checksum="CC59976031A8D4EB" modified="2017-06-07" version="1">MNKKKVIIGVLIALIFVMIAFVPAADNMHTVHGNAAVNKISPQLAIGNYAVNGNTYNNFEQNNFAKGDLNWKAVNLAKSPSLSGKPVTGSYAAVNNKIYTQLSISNISIAHKYTNKITEILGSNYNEYIKTTGNSVYIKSIIYKSNQNTWIPNNSMYMITGSHARLITFDPHTYHKSYGWGNAYVFYDSDTFYGSIGARNYYIMLGLITTDAGIATDTALIAAPEVAAVAVALEAVVVAAWAVFTNDHISSQGTTIPYVEFDVSVGNWWDFWDTGIYGELGAHSNRAYNFNGNLTYSGQWAYFPFLTTAPPDLQVPSLLPHSSVWPTLSPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N595</accession>
    <name>A0A1V0N595_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886550.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N595"/>
    <dbReference type="STRING" id="74969.FAD_1445"/>
    <dbReference type="GeneID" id="16024674"/>
    <dbReference type="KEGG" id="fai:FAD_1445"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="18"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="477" mass="52004" checksum="790BD4A27BAF74D7" modified="2017-06-07" version="1">MTENETGSQIKIPGRSVITTLSAMGYFLDGYDLSVISVFTLVLVTFKPFHYDPFTESFVTGAALLGAFVGAVIFGHFADNIGRRYLYIFDLIFFAVFAILSALSTNIYEMIIFRFFVGWGVGADYALSPVYTTEMYPDKKRGAGYGWVWTFWSIGAGAAFAIGYVFYMINPLVGWRYTLAIGAIPAIVTVVLRTRMPESVRWDILEPGKSKLSAKDLDSIAERVGITKEDIKAIIAEREKEENIAAGSFTALFKGEYGKRTAIIWFQWILYDIAGYGIGLYSPIILTTLGISHSSSLLFSLIFNMPVGFLGAFGAVMLNDRLGRRPLQALGFGGMAIAMAMFFIASSAIASIGIIIGIAAFVIDYGIGNLGPGDTMGLYAIELLPTKLRSSSMGGATGITRIASFLAAFMFPLISASLGKSSFFFILLGLMVLAFVFTIFFTPETKGLTLEEIALASYKHVHGVPKLILPEAKKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5A1</accession>
    <name>A0A1V0N5A1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter 1, ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_1460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886565.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5A1"/>
    <dbReference type="STRING" id="74969.FAD_1460"/>
    <dbReference type="GeneID" id="16024690"/>
    <dbReference type="KEGG" id="fai:FAD_1460"/>
    <dbReference type="OrthoDB" id="10909at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050166">
        <property type="entry name" value="ABC_transporter_ATP-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788:SF13">
        <property type="entry name" value="ALIPHATIC SULFONATES IMPORT ATP-BINDING PROTEIN SSUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788">
        <property type="entry name" value="TAURINE IMPORT ATP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="263" mass="29580" checksum="534A3F52CF152DAB" modified="2017-06-07" version="1">MEMGIKDENVTNSILEAEGIYFSYDNGYDVFENINIEAEPGKFIAIIGPSGIGKSTLLRILGGFLKPDKGIVRLMGKPLYEPTPEVALIHQSIVTFPWMDAKENVMLSMKTKNMTKDEMEEKATVSLSRVGLDGFEDLYPKEMSGGMRQRVAIARAFAADPYVFLMDEPFAHLDELTAEGLRQDIYNILFSGETPLKSVIMVSHNLTEVLELADEIYILNNIPATVISKVQVTMQRPRSPRSDEFNANLDMLYSYLTPPRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5G1</accession>
    <name>A0A1V0N5G1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1468</name>
        <name evidence="7" type="ORF">HLB00_04510</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000152">
        <property type="protein sequence ID" value="NOL60097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886573.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5G1"/>
    <dbReference type="STRING" id="74969.FAD_1468"/>
    <dbReference type="GeneID" id="16024698"/>
    <dbReference type="KEGG" id="fai:FAD_1468"/>
    <dbReference type="OrthoDB" id="9362at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="542" mass="57996" checksum="A0A78C712F7064A6" modified="2017-06-07" version="1">MIGGQPIFILKEGTKRESGKDAMFENIDAAKAIATSIRSTLGPRGMDKMLVDSLGDIVITNDGVTILKEMDVEHPAAKMMVEVSKTQDSYVGDGTTTAVIIAGALLDQAQSLVKQNVHPTVITEGYKTAAAQASRVLEEISRPVTLKDKEILIKMAKTSLNSKSASVEKELLGTISYNAIKTIAEERDGKYLVDFDNLQVVKKNGGEINQTELIDGIILDKEKVHPNMPKLVKNAKIALLDLALEIKKPEFDTNLQINDPSMIQKFLGQEEDVLKEMVDKIKATGANVVITQKGIDDMAQHYLSKAGIYAVRRVKKSDVDKIAKATGATIVSSLEEIVASDLGAADAVEERKIGDDYMTFVTGSKNPKAISLLIRAGTEHVADEIERSITDSLHVVAAAVEDGAYTTGGGSAAEEIAFNLRSYATKVGGRQQLAIEKFADALEEIPRALAENAGLDPIDILIKIRSEHANGHKTFGVNVFSGNVEDMEKAGVIEPIRIGKQAVEASTEAAVMILRIDDVIATKSSKGGSPGGAGGMPPGGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5G4</accession>
    <name>A0A1V0N5G4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5G4"/>
    <dbReference type="STRING" id="74969.FAD_1539"/>
    <dbReference type="KEGG" id="fai:FAD_1539"/>
    <dbReference type="OrthoDB" id="6635at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF20">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN, SUBUNIT BETA (ETFB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="1">
        <location>
            <begin position="56"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="278" mass="30588" checksum="79B8031F2D1908C5" modified="2017-06-07" version="1">MNIQYYIENSGNMYNGIQALFPTLKKLNRVLIWAIMDIAVLVKQTVDMDQIKLNDENEPIMDNLPLKMDILSKNAIEAAVQLKEKYSGKVTGFIFGTEKSTSTMKEAYAMGVDEGTVIKGYQKSDPLVTAGVIAAELKKAKYDIIILGDQSSDSYSGLLAGLLASELDLNVITNAINIEVKDKIANVTVESENEDVTVETGLPAVVSVAQEINEPRLPKVMQIMMAGKKNINIVDGNPGYEDDTKILSDRAPENERKKIIYEDGKGIDEVAKILKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5G5</accession>
    <name>A0A1V0N5G5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5G5"/>
    <dbReference type="KEGG" id="fai:FAD_1486"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="64" mass="7581" checksum="0FBDAD4926679D59" modified="2017-06-07" version="1">MNGLLIPGNIHSKIFFLITCTQISDSLNLRDGVKWYDMRRECFYKKLFIIVYYCLLSLNDENSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5H3</accession>
    <name>A0A1V0N5H3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1481</name>
        <name evidence="2" type="ORF">HLB00_03075</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 4">DSM 28986</strain>
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    </evidence>
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            <dbReference type="EMBL" id="NOL59817.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
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    </evidence>
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</entry>
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        </location>
    </feature>
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    </evidence>
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</entry>
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            </authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="ARD85394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="70" mass="8234" checksum="B18DE45E124BBDDB" modified="2017-06-07" version="1">MLTILIGSLARRDYTPFSDDDVIIITDSTRSEIEFMDPYMPIDIEPRVFTINRIYEMAKSLLVTMRYLII</sequence>
</entry>
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    <accession>A0A1V0N5M8</accession>
    <name>A0A1V0N5M8_9ARCH</name>
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                <person name="Tatusov R.L."/>
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                <person name="Golyshin P.N."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="NOL59913.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="91" mass="10795" checksum="E567C27FF107622D" modified="2017-06-07" version="1">MALKSMERGDLEKFIDEIEINSKEAYKLWNFKNEDEFISFLKGYIFGSFTMGVIDKNKTINKNFMLKEEDINEITAIIERRSSEFRANLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5S8</accession>
    <name>A0A1V0N5S8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Manganese/divalent cation transporter</fullName>
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    </protein>
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        <name evidence="7" type="primary">mntH</name>
        <name evidence="7" type="ORF">FAD_1593</name>
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    <organism evidence="7 8">
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        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="65"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="211"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="414" mass="44925" checksum="F12B9FDFE791D9A4" modified="2017-06-07" version="1">MDVDDLHKRRRLLNRDTIALFGPAWLVMMADMDASSYIGAAQTGATLGYGLIWLMLILIIPLYVIQELAGRIGIATKGGLGDIVRKNYGKRIASIVALPMALTDTVTYGIEYLGIGIGLEIMGLSIYYTIPVIYVIHILIVTRKKYSEAEKPLIIISLLLIIALLLSLALRGIIPVSSPLANPILIKPTAGYFFLLAANVGAVIMPFMIFFQASATGLKLGDLDGGHIRITRRRSLRIMRKETLAGAIVTELLMVIAEMAFAGIPHANHSSFFATPQQLGKVLIPVAGSFSPIILGIGLIAAGFIALITISLGSAWGIAESLNLKKKSYWIIYILESLPAVVAIMLINPSSMIAIVLYLLIFFVFALIAPLAMMWIIGRNKNIMGDLVLSRKNEVVYLLMFGLIIATACIAVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5U7</accession>
    <name>A0A1V0N5U7_9ARCH</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Ferroplasma acidiphilum</name>
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        <lineage>
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            <taxon>Methanobacteriati</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ARD85474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="JABGBP010000075">
        <property type="protein sequence ID" value="NOL59692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5U7"/>
    <dbReference type="STRING" id="74969.FAD_1630"/>
    <dbReference type="GeneID" id="16024897"/>
    <dbReference type="KEGG" id="fai:FAD_1630"/>
    <dbReference type="OrthoDB" id="26319at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42696">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="10"/>
            <end position="339"/>
        </location>
    </feature>
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            <end position="453"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85474.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="NOL59692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="455" mass="50529" checksum="3724CA2BFA7741E4" modified="2017-06-07" version="1">MRTERDVIGEVQIDDSIYYGINTLRAKNNFNISGIKSKDRDHIKAMAIVKKGAAYANYTAGKLQKELYESISKACDRLISGDFDEQFVVDVFQAGAGTSFNMNTNEILANLVLESLNHKKGEYKYAHPNDVINMSQSTNDIYPTMMRVSIMLKSPKLIENAEALIKSLKAKHKEFEKVYKTGRTHLQDAVRVTLGDEFNAWAFAIGRDLKEFKSALDYILELNIGGTAVGNGANTPDGYKEYAVKKISEETGFNFRPGENLMGIMQFMTDFSRVINSLSNMALDLSKISDDLRLLYSGPGAGLHEIVLPAVQQGSSIMPGKINPSIAEAMNMICHSITGSQQAVNLSVKAGQLELNVMMPHIDYEISKSIERLANGIKMLDEEAIQGIKPDLNKIKENIERSFGSAALLNPYLGYDTMAKIVEESLETGKSIKDLVLATGKIDEKKYKEIFNFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5V9</accession>
    <name>A0A1V0N5V9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1669</name>
        <name evidence="3" type="ORF">HLB00_00435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000012">
        <property type="protein sequence ID" value="NOL59306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143012.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5V9"/>
    <dbReference type="STRING" id="74969.FAD_1669"/>
    <dbReference type="GeneID" id="31677160"/>
    <dbReference type="KEGG" id="fai:FAD_1669"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="189" mass="21483" checksum="C5A4E788130EE0A7" modified="2017-06-07" version="1">MNYKSLLRIFLILLVIFAVLITSIPFANHYDNSFTLNTKNNITEKYNGTTHYIIQGRYYSAFFRTYGGKLKLMPDTSIIENGQNYTINNCVSIYSVSLHYNNSTGHKIFEKNILNTVNVNLTAGYYMIKYNSTLTIYGRENSSQVNKLNLIVVDPPGNYAMMAIIYIFAIPTAATGILSGILYNKNKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Z2</accession>
    <name>A0A1V0N5Z2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Replication factor C small subunit</fullName>
            <shortName evidence="7">RFC small subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfcS</name>
        <name evidence="9" type="ORF">FAD_1690</name>
        <name evidence="10" type="ORF">HLB00_06145</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000211">
        <property type="protein sequence ID" value="NOL60413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886831.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Z2"/>
    <dbReference type="STRING" id="74969.FAD_1690"/>
    <dbReference type="GeneID" id="16024962"/>
    <dbReference type="KEGG" id="fai:FAD_1690"/>
    <dbReference type="OrthoDB" id="7928at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000952">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01509">
        <property type="entry name" value="RfcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023748">
        <property type="entry name" value="Rep_factor-C_ssu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL60413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="318" mass="35886" checksum="1E1F365298A9A240" modified="2017-06-07" version="1">MLNIWTEKYRPSKLSDVIGEKGNINRLNAYVKDKNIPHLIFAGPQGTGKTSTAIALAISLFGDSWKENFMELNASNDRGIDIIRDNIKNFAKIRPSNDLGFKIIFLDEADHLTGDAQAALRRTMEMFYNTTRFIFSCNYSSKIIPPIQSRCVVLRFKPIDRESMKNRLKDIAKKENFEIDDDSLDAIYEISDGDMRKAVNVLQAVKLSGKVSATAIYEISGEINRDEYKNLINMAIEGNFNDARNYLDKMLIDYGLSGIDIIKGMHSSIRGEQIAYKQKLEIIMALAEAEFRIVEGGTDNIQMDALLAKLSYIGSEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N606</accession>
    <name>A0A1V0N606_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0749</name>
        <name evidence="3" type="ORF">FAD_1592</name>
        <name evidence="4" type="ORF">FAD_1683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886695.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N606"/>
    <dbReference type="STRING" id="74969.FAD_0749"/>
    <dbReference type="GeneID" id="16026028"/>
    <dbReference type="GeneID" id="31677175"/>
    <dbReference type="KEGG" id="fai:FAD_0749"/>
    <dbReference type="KEGG" id="fai:FAD_1592"/>
    <dbReference type="KEGG" id="fai:FAD_1683"/>
    <dbReference type="OrthoDB" id="210900at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="121"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="287" mass="34307" checksum="708B5DE421552C13" modified="2017-06-07" version="1">MKLNEKKIKYIIREKNKRRSSTEIAKEMKITTRYVNYIYKKYRDNGEYTIGKRKHRELNSKDIEIVKKIRYEYPMSGPERIRKYLKRKGIIIAKNNIYRILLLLNMVDNSNNKKKQRKYIKYERKHSNSLWHMDWTKYSDSEKLIIIEDDASRFIVGMGIYGEETIDNTIEALEIAINTYGKPEEILTDHGTQFFSNGKNGIPGDHNKFQEYLDNSNIKHILGRVKHPETNGKLERLNYTIKRLRPYFSTWEEVVYHYNYERMHDSLSDGDNIVTPAMAYKNKMVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N641</accession>
    <name>A0A1V0N641_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841519.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N641"/>
    <dbReference type="STRING" id="74969.FAD_1748"/>
    <dbReference type="GeneID" id="16025023"/>
    <dbReference type="GeneID" id="31677239"/>
    <dbReference type="KEGG" id="fai:FAD_1748"/>
    <dbReference type="OrthoDB" id="75495at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030554">
        <property type="term" value="F:adenyl nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043168">
        <property type="term" value="F:anion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="10"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="333" mass="36230" checksum="91FFB60555EF0CEA" modified="2017-06-07" version="1">MKAYVLKEPGVLELINTEARKPDTGEVQIKTRACGICGTDFHAYNGKHLAVKYPVIPGHEFSGVITSIGEGVKSFMPGDRVVVDPNITCGQCEYCKGGKENFCENIKTVGINYPGGYGEYVTVPEKVVYKIPDTMSFEAAAIVEPVACIIHAFDNTHVPLGGSAIISGTGFIGLAFLQILKGMGYYPVYTMDTNPTRNLLAKKYGSDKIYTGIDDLMESDIIGKANVVVEATGSNSILSKTIDMASPSGKIFAFSVYPPGEKIEIESNKIYSKEISIFGDFVNPYTMRKAINMISSGLIDYSGMEDPVIKINDIGNLFQSGKRNFIKPLISYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N652</accession>
    <name>A0A1V0N652_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841520.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N652"/>
    <dbReference type="STRING" id="74969.FAD_1752"/>
    <dbReference type="GeneID" id="16025027"/>
    <dbReference type="KEGG" id="fai:FAD_1752"/>
    <dbReference type="OrthoDB" id="52955at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046057">
        <property type="entry name" value="DUF6015"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19479">
        <property type="entry name" value="DUF6015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="141" mass="16588" checksum="AC6926C4205C516C" modified="2017-06-07" version="1">MATSSMEIAKLRSRAYVKIDELSKAISNGLSLQNRKMGIEESQSSAEHIINFFGYSTRVIDNMLEPEDRDVFYTMEDLGILETEREETTLFDGREWRIHYWLLNVLRVLELAEMNISNKVEHDSRFDIYSEIPDEYWKPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N682</accession>
    <name>A0A1V0N682_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable tRNA pseudouridine synthase D</fullName>
            <ecNumber evidence="4">5.4.99.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(13) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">truD</name>
        <name evidence="6" type="ORF">FAD_1782</name>
        <name evidence="7" type="ORF">HLB00_08035</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(13) in tRNA = pseudouridine(13) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42540"/>
            <dbReference type="Rhea" id="RHEA-COMP:10105"/>
            <dbReference type="Rhea" id="RHEA-COMP:10106"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.27" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000298">
        <property type="protein sequence ID" value="NOL60775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143086.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N682"/>
    <dbReference type="STRING" id="74969.FAD_1782"/>
    <dbReference type="GeneID" id="84218405"/>
    <dbReference type="KEGG" id="fai:FAD_1782"/>
    <dbReference type="OrthoDB" id="1798at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160150">
        <property type="term" value="F:tRNA pseudouridine(13) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02577">
        <property type="entry name" value="PSTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01082">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="158"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL60775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="414" mass="47646" checksum="54EF53E76C86E9A0" modified="2017-06-07" version="1">MEDSIIGINGYSTDTPGIDGNIKYDPESFIVNEIPVTIPENNNGKYTILKVRLRNWDTNKFLMYLADQLHISNKRITYAGTKDKIGITTQYFCINMPENQQINNISIKDAEIISSFRTDKLVKLGDLLGNEFIISIQSTDDNTQKIGETVESIVKNGGFPNFYGYQRFGSIRANTHKIGKLLVQNKYEDAVKTYIYDPEFDREDYRRTFGETGDAKRAIKEFPEYLTFERSLLGYIIRENTYKNAFSVFPRNLSMLFIHAYQSYLFNRILSDRMKYAGSMHKVLEGDLLYPVDRYFNPDRSQLIRASSYNIEKLNNLSRENRIRTVIPLIGYSTELSSGIEGEIESRIMAEEGIEKKDFNLSSDRRLGSSGDYRIMSVLPVDFKIIEKNRINFSLGKGIYATSLLRELIKGDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N697</accession>
    <name>A0A1V0N697_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCA-adding enzyme</fullName>
            <ecNumber evidence="10">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cca</name>
        <name evidence="14" type="ORF">FAD_1844</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a tRNA with a 3' CCA end + 2 CTP + ATP = a tRNA with a 3' CCACCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:76235"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="Rhea" id="RHEA-COMP:18655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="ChEBI" id="CHEBI:195187"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143119.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N697"/>
    <dbReference type="STRING" id="74969.FAD_1844"/>
    <dbReference type="GeneID" id="31677334"/>
    <dbReference type="KEGG" id="fai:FAD_1844"/>
    <dbReference type="OrthoDB" id="7378at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
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        <property type="project" value="RHEA"/>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Beta Polymerase, domain 2"/>
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    </dbReference>
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        <location>
            <begin position="48"/>
            <end position="135"/>
        </location>
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        <location>
            <begin position="150"/>
            <end position="256"/>
        </location>
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        <location>
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            <end position="408"/>
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        <location>
            <position position="50"/>
        </location>
        <ligand>
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        </ligand>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6B5</accession>
    <name>A0A1V0N6B5_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">FAD_1834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
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            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
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                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Y</strain>
        </source>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="75" mass="8955" checksum="010B0FB0A4DC8E4F" modified="2017-06-07" version="1">MRKFSEYFTVFFFYRLTGIILFLSGFVFYLFWGIEYSGWKDSGLISFVVPLILLGLLTIWLGNEKEKENRKLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6C5</accession>
    <name>A0A1V0N6C5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter related protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1800</name>
        <name evidence="8" type="ORF">HLB00_07595</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily. Drug exporter-1 (DrugE1) (TC 3.A.1.105) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="NOL60691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="31677290"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DrrA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582:SF2">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DrrA1-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="327" mass="36498" checksum="F63C381706A5E910" modified="2017-06-07" version="1">MDYSIEIDKLTKIFNGKVTAVDNVSLKIGSGQIYGLLGQNGAGKSTLIKMLTGSLTPTSGTAKIAGLDLTKDSMKIRKITGVVPQDLTTDGDLSGRENLKLIADLYGIPKKEALERIDVLLHMVDLYDVRDRHAENYSGGMRKRLELACGLMNTPEVLFLDEPTLGLDVTTRENLWKYIRSVQKEFHITIILTSHYLDEVDALANELSIIDHGKIIISGTSDELKKSLKGDIITLKVKNDDEYSKLEKFPESLEIKRMETGDVRMKVNNSDEVLPKLMKFLGENEISPEAISIRKPSLDEVFIEYTGRNINSEAGNTDYAKLMMGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1E0</accession>
    <name>A0A1V0N1E0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 9">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887034.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1E0"/>
    <dbReference type="STRING" id="74969.FAD_0023"/>
    <dbReference type="GeneID" id="16025169"/>
    <dbReference type="KEGG" id="fai:FAD_0023"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD83958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="116" mass="12645" checksum="98688DFB67F9D9B8" modified="2017-06-07" version="1">MVKMVIAVRKDLAMGKGKIAAQVAHAAVACTLISMKKNKKTFNEWYETGQKKVVVKVDNLQEIYKIKEECKILGVISETITDAGFTQIIPGTVTCIGLGPDEDDLLDQITGSYGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1E4</accession>
    <name>A0A1V0N1E4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OFA family MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Oxalate:formate antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0037</name>
        <name evidence="4" type="ORF">HLB00_02720</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Berkeley</strain>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000086">
        <property type="protein sequence ID" value="NOL59747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141256.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1E4"/>
    <dbReference type="STRING" id="74969.FAD_0037"/>
    <dbReference type="GeneID" id="84218528"/>
    <dbReference type="KEGG" id="fai:FAD_0037"/>
    <dbReference type="OrthoDB" id="359492at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17353">
        <property type="entry name" value="MFS_OFA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF304">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD83972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="NOL59747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="370" mass="40311" checksum="9D9F9206D8F594EB" modified="2017-06-07" version="1">MKKGYIIIGIVIMSFNSLYQYSWDVFEPLLKTGLNVTLVQVEVAFTLFAIFSTGFQGIGGYFADKNGPRNIGILSAILSSIGFLGTSFIHNLYLFYILWSLGSIGEGILYGISTNLAVKWFKGRRGFAVGLVSLGFGLGAAVANIFIAKAVSFRTPMLIIGVAEIIILPALLMKARYPETATLTGEKTSKNLKNTRFWILYISFILGAVPLIVISASFGYLGEALPLVEFTILVSLFPLLSGVSRPILGYVSDIIGRVKVVMLIDSFLILGSIFLILRLYVFAIIFIGFFGGAMISMYFSLVGDIFGTRFSTANNGVFYTGKAISGFMGSTIFAALFLFDHEISFIFVLISSIAAIMFLLASVPKKKPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1F6</accession>
    <name>A0A1V0N1F6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0018</name>
        <name evidence="3" type="ORF">HLB00_05680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000190">
        <property type="protein sequence ID" value="NOL60323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887029.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1F6"/>
    <dbReference type="STRING" id="74969.FAD_0018"/>
    <dbReference type="GeneID" id="16025164"/>
    <dbReference type="KEGG" id="fai:FAD_0018"/>
    <dbReference type="OrthoDB" id="381766at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046739">
        <property type="entry name" value="DUF6789"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20587">
        <property type="entry name" value="DUF6789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="176" mass="18827" checksum="02384283E93FB95F" modified="2017-06-07" version="1">MGKAGLGAKAGVVAGLVYGILDGIFAYVVLVIFKTDVMKVMSTLAAKETSLGIKVTGAQLYSTDLTLAPVEGIVGGLIIGIILGIIFAYTHNKIPGKNMIIKGEIFGLILWIIFDVLIGAVDISTYGLTYYIASIAFDIIPLVVFGFILGTLYNKWEVKDTPVTDEEFNKMNSGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1I2</accession>
    <name>A0A1V0N1I2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="6">OPRT</shortName>
            <shortName evidence="6">OPRTase</shortName>
            <ecNumber evidence="2 6">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrE</name>
        <name evidence="8" type="ORF">FAD_0079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141298.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1I2"/>
    <dbReference type="STRING" id="74969.FAD_0079"/>
    <dbReference type="GeneID" id="31675591"/>
    <dbReference type="KEGG" id="fai:FAD_0079"/>
    <dbReference type="OrthoDB" id="9089at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="6">
        <location>
            <begin position="109"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="166" mass="17901" checksum="F275568E8910F2CE" modified="2017-06-07" version="1">MDREKFIQSGMIKFGDFTLTSGKKSTYYVDIKEACTDPATLSEICDDLAGKTIYGTVAGMELGAVPLIVGISLKTGKPYIIIRKGEREHGTKKQIVGNIISGSRVDLIEDVVTTGNSLLKTAKILRENGAIVDHAVCVVDRESGGEELLKENGIKLESVAKISELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1I5</accession>
    <name>A0A1V0N1I5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1I5"/>
    <dbReference type="STRING" id="74969.FAD_0065"/>
    <dbReference type="KEGG" id="fai:FAD_0065"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD83998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="108" mass="12504" checksum="CD04384CFAF7B521" modified="2017-06-07" version="1">MIMNNLGELMEAEITNFREYYDNKIITALIGIEAEINNVDAIGRIIGEHKNVEEVFVVTGEYDLIIKVRFPDYIALEKFIVNNLNSIQGIRKSKTMMVLSIIKDMYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1J4</accession>
    <name>A0A1V0N1J4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome d ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_0054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD83989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940578.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1J4"/>
    <dbReference type="STRING" id="74969.FAD_0054"/>
    <dbReference type="GeneID" id="31675567"/>
    <dbReference type="KEGG" id="fai:FAD_0054"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016682">
        <property type="term" value="F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME BD MENAQUINOL OXIDASE SUBUNIT I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
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            <end position="214"/>
        </location>
    </feature>
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            <end position="245"/>
        </location>
    </feature>
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        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="501" mass="55684" checksum="F67CDA0875A1FCB9" modified="2017-06-07" version="1">MFNISYPVWDSAMFAYTISAHILLVSLSMGLAITVTIAEFLALKKKDKYYDTLAYKLSKALVIFFAVGTASGTVMAMELFLFWPSFMKLVGEVAMGPFYVEVFSFLLEAIALPMYVYFWKDFKNRWEHWGLSLAVTIGTYLSAFTVTEINAWMNTPNGFDVAKFVSSNGTVITNVNPFAPFITASTAAEELHMSGAVYYAGIAMILGYLIYKYLKTTNMSEKMIYRRGINITAVFMILDIIYLGATGSNELSTLMVIEPIKYTALELDLHATIGTSFATMAPEHIFGVLINHKLAYAPSFPYAQSLLAFPLTFGKGSIPGLIPLTTYKGVTDYGVWPPYVVHDTLDLMVGFGVLMGLYWLYVVVQYFRKKDPLSHRFTLLGGIVVAIMGVFTMEDGWYTAEVGRVPFIIKSPVPGGFVVDGTKYYGTMTIAHAASTSPLVFPLGIAIIIFYLALFPLTFYFAGKVMKLSNVDEDLKLGEDDIKMEDERKARKSVSAKAGMR</sequence>
</entry>
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    <accession>A0A1V0N1M1</accession>
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    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
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    <reference evidence="2 3" key="1">
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            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
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        <location>
            <begin position="5"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="ARD84019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="294" mass="34965" checksum="EAB750618EC9008A" modified="2017-06-07" version="1">MTDLLEDFETKKEAIRDEVELHIKKRDEANAEAQKYAKIRDELNQKTHEMREHAKEKIAEKNELIEKIKTLRDEKEVHYKNLSELKKQLREYRSSLGTNIDIKDIKAKEKELQYLERRQQTTELKKDEENKIIVEIRRLNNEIKKSKTLREQELLKNGDVKELTDKINEERTVGEEYKKEIEDLSNRISQLSDEINDELQKLDEVRKVADENHETFIKYSQESEAEHAAFLKAKIELKDMEKAIYSIRNKSKVTKRKEKESELQEKASELYEKFKAGEQLTTEDLLILQKAGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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    <gene>
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        <name evidence="6" type="ORF">HLB00_07345</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84005.1"/>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1N0"/>
    <dbReference type="STRING" id="74969.FAD_0072"/>
    <dbReference type="GeneID" id="31675584"/>
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    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="257" mass="27645" checksum="E239A4787CC541DB" modified="2017-06-07" version="1">MNTIEVTNLYKRYGTTTALNGINLSIAGGQIYGILGPNGSGKTTLLKILAGILPPSSGEVVIDGMNLTGNSDNIKSITGYIPETPALYESLTPIEYFNFLASVFKIDDSVLKERINAFSNALEIGKYLNEFIGSLSFGTKQKVAIIGSLIHDPKIIVMDEGMNGLDPKSSKIIKELLKDMTAKGKTVIFSTHIMEIAETVCDTISILYNGNIAGTGNLDQLKSEAGSNNSDLEGVFLKLTGDEDLDNLLDSLRESIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1N1</accession>
    <name>A0A1V0N1N1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uncharacterized membrane protein Ta0354 soluble domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141368.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1N1"/>
    <dbReference type="STRING" id="74969.FAD_0131"/>
    <dbReference type="GeneID" id="31675643"/>
    <dbReference type="KEGG" id="fai:FAD_0131"/>
    <dbReference type="OrthoDB" id="384681at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.290">
        <property type="entry name" value="Hypothetical membrane protein ta0354_69_121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036171">
        <property type="entry name" value="Ta0354_soluble_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024504">
        <property type="entry name" value="Unchr_Ta0354_soluble_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11433">
        <property type="entry name" value="DUF3198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116858">
        <property type="entry name" value="Hypothetical membrane protein Ta0354, soluble domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Uncharacterised membrane protein Ta0354 soluble" evidence="2">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="121" mass="14388" checksum="C455EF46CB4A1C89" modified="2017-06-07" version="1">MYRDKLYIVYIIISIVSLLFLIISLNGLLFHNQYLINLIPLKSLGNWQYWILIASTIVFIYFAYLTYSILNDIYTFKKLLKSSSKKTFIDNMPSLERISKRLGKNYDELLKQAKHKWGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Q5</accession>
    <name>A0A1V0N1Q5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_0137</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887143.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Q5"/>
    <dbReference type="STRING" id="74969.FAD_0137"/>
    <dbReference type="GeneID" id="16025282"/>
    <dbReference type="KEGG" id="fai:FAD_0137"/>
    <dbReference type="OrthoDB" id="7798at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000075">
        <property type="entry name" value="Translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022424">
        <property type="entry name" value="TIF2_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03680">
        <property type="entry name" value="eif2g_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="3"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD84068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="406" mass="44158" checksum="34E9F380A9C38B56" modified="2017-06-07" version="1">MEQPSVNIGMVGHVDHGKSTLTFALTGKKTDVHSEEVKRGISIKLGYADTPIYRCTDETGKEFYSNKKNSDNCQLSRVISIVDAPGHETLMATMLAGSAIMNGAILVIAANEECPQPQTREHLTALEIMGIKEIIVVQNKIDLVTRERAMESYKEIKDFLKGSIAENAPVIPVSAYHNTNIDVVFEAIEKIIKTPPFNDNDAPMMYIARSFDINKPGTKPSKLKGGVLGGALIRGKLTVGDEIEIAPGVQITKGNKTTWDNVTTKITSLMAGSSSYESILPGGLAAVGTELDPFLTKGDSFTGRIIGLKGNVPKTVFNMEMDIHLLNRVVGFDEEVNVEPLKSNEMIMLTVGTANTIGTVTSIKDKRVGVSLKYPVAASINDRMAIGRRISNRWRLIGYGSILTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1S0</accession>
    <name>A0A1V0N1S0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="5">2.1.1.166</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">23S rRNA Um2552 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">rRNA (uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rlmE</name>
        <name evidence="8" type="ORF">FAD_0113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(2552) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyluridine(2552) in 23S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42720"/>
            <dbReference type="Rhea" id="RHEA-COMP:10202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141350.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1S0"/>
    <dbReference type="STRING" id="74969.FAD_0113"/>
    <dbReference type="GeneID" id="84218603"/>
    <dbReference type="KEGG" id="fai:FAD_0113"/>
    <dbReference type="OrthoDB" id="26307at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="16"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="194" mass="22200" checksum="5DF2DCEAC12D7B82" modified="2017-06-07" version="1">MNRKDRYYTRAKKDNFRSRASYKLLEIQSKFNVIWKTDYVIEFGSSPGGWTQVVQKLTEKPVIAIDISPMDPIENVTFVQGNINDPELSEKIKIAMDSLGISSVSTVLSDAMIKTSGNYDRDHMGSYLLCDNVMNLSIDLLSPGGNVVLKQFQGDSTMAFVNKWKVYFNYYKVTKPNASRQHSREVYIIFKDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1S4</accession>
    <name>A0A1V0N1S4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ORF">FAD_0112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141349.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1S4"/>
    <dbReference type="STRING" id="74969.FAD_0112"/>
    <dbReference type="GeneID" id="84218602"/>
    <dbReference type="KEGG" id="fai:FAD_0112"/>
    <dbReference type="OrthoDB" id="9810at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="124" mass="14060" checksum="3B8F3947EC76D76D" modified="2017-06-07" version="1">MSKIPENLKYTKSHEWFKIDGDVATVGITDFAQHQLTDIVYVDMPKKGTVKKAGETLLTIESVKSAEDVFFPVTGEVIETNEELDKKPELVNSDCYTNWLVKIKLTDNKYDSMTAAEYKSYIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1T2</accession>
    <name>A0A1V0N1T2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1T2"/>
    <dbReference type="KEGG" id="fai:FAD_0149"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="58" mass="5856" checksum="780AEAB2F0A6E5B2" modified="2017-06-07" version="1">MGLLLGGFGTAILSIYSLLPFAAYTAILGVAVFIIGLGITALASTKISLNAGNDNKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1V7</accession>
    <name>A0A1V0N1V7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1V7"/>
    <dbReference type="STRING" id="74969.FAD_0157"/>
    <dbReference type="KEGG" id="fai:FAD_0157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF18">
        <property type="entry name" value="METALLO-HYDROLASE MJ0296-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="192" mass="21857" checksum="A6BACF1A2C49048B" modified="2017-06-07" version="1">MIIPNTVVNVYVIKYMGTVIQIDAGIKSDANKVINFYKDSGLNPDYILITAVDYIHVGALRDIYDVYNPKIYVPKREMGSMKNGPTLRGILEVEGKGLQFEGIQHVYSYNKMDIDFLEVIGTPGYTMDNVSIYFRDKNSLFVGDSIIIKRNKIKIDSMFTQNMQMARSSLDKIKEFCPATLFPSHGNPYRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1W2</accession>
    <name>A0A1V0N1W2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Adenylate kinase</fullName>
            <shortName evidence="12">AK</shortName>
            <ecNumber evidence="4 12">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">adkA</name>
        <name evidence="14" type="ORF">FAD_0183</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the archaeal adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="4 12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887188.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1W2"/>
    <dbReference type="STRING" id="74969.FAD_0183"/>
    <dbReference type="GeneID" id="16025331"/>
    <dbReference type="KEGG" id="fai:FAD_0183"/>
    <dbReference type="OrthoDB" id="26198at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00234">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023477">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003122">
        <property type="entry name" value="PRK04040.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="180" mass="20462" checksum="C63D7853F58E1A20" modified="2017-06-07" version="1">MRVVISGIPGVGKSTILDMVSKKSMYEIINFGSLMFDMARDLDLVKSRDDIRRLDVDTQRNLQKKTSNQLGKMDNIIIDTHMSIKSPAGYLPGLPAWVLNELMVSSYFLIESTPAEIKRRRDNDSTRSRDEDTINDIEEHQQVNRYYAAAYSVYSGATIKYIYNPDNHPEIAAEAILRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1X2</accession>
    <name>A0A1V0N1X2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1X2"/>
    <dbReference type="STRING" id="74969.FAD_0227"/>
    <dbReference type="KEGG" id="fai:FAD_0227"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="294" mass="34542" checksum="2096D6BA2410BE87" modified="2017-06-07" version="1">MEIIDNIVSPDDRKRKYTDRQILKVLIVLQIFNISYRSARIFLTNHEEYIRMAGLNEIPSFQTLSRRARMIDLHAVNNEITYLYSIESIAAIDSFIIHTCKHSTAMRRKAWNNYKDPVSGWSKTTKGWSYGRKCHMAIDVDSLIIMEWMVTKGNMHDSHVSHDMVDSVRDFSYVLADSAYDASDIYDYIFENTHALPVIDTNRRRGIVDNRLPLNRKIGIDMRKEYASMYPLRWEIERTFSILEEILKCENIWYTVNRDYDTAIGLKTIAYNLMIISNMELGEKPREIMKIVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1X7</accession>
    <name>A0A1V0N1X7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141395.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1X7"/>
    <dbReference type="STRING" id="74969.FAD_0194"/>
    <dbReference type="GeneID" id="84218682"/>
    <dbReference type="KEGG" id="fai:FAD_0194"/>
    <dbReference type="OrthoDB" id="39489at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050583">
        <property type="entry name" value="Mycobacterial_A85_antigen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48098">
        <property type="entry name" value="ENTEROCHELIN ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="314" mass="36093" checksum="152A2AB4C664A685" modified="2017-06-07" version="1">MPLQSELVDIKSKVLRNNALGDPDERKILVFHPEELDPGAPLLIELAGLNGTPKLNNRFSQVLNKLYKRNMLGNAVIINPDFSTKYHVNQYMNSPAAGNYEDFIIKEIIPFISERYKTGKTALFGKSSGGFGAYTLAARNPEIINGFADHFGDSGFEYVYIPDIPVTYRELGDKDINEYVHEKSLKEDLNDNEIRALNILGMSAFYSYNNSESGFDLPFDRKTGMFRDDIWSRWSSFDPARNVDNNIENLKKLDAIYLDVGLKDEYNLYMGMRSLHRKMENFNISHRYNEFDGGHFYNTPRYEESLPFLVEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N246</accession>
    <name>A0A1V0N246_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887244.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N246"/>
    <dbReference type="STRING" id="74969.FAD_0236"/>
    <dbReference type="GeneID" id="16025389"/>
    <dbReference type="KEGG" id="fai:FAD_0236"/>
    <dbReference type="OrthoDB" id="56286at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="281" mass="30243" checksum="2029C4A678A23681" modified="2017-06-07" version="1">MRYKLLILFLAVFALIALSGTAASGSNTHGNSPETSSSSFSPGISVPTYVYENETFYLNVTEFTSGYHNYSLSAYLGAENDTGLSPLFYYGHSKTGNFSIPVTAPSEIENIHGFINATAVNSTGSTVSSVSSISLINVSAPVIFNSTIKNTDPVPITNITVTYTISHGTSSVVAGISHINEIKSNSTYKDNITVPASLVYKGKDTLTVTTNNPVITIAGKSTTTFYYGQSPNYDWVYYIAAVAVAFSVFLIVASGRRNTVKVPKWKRSKSSRKSKKLEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N247</accession>
    <name>A0A1V0N247_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps12</name>
        <name evidence="10" type="ORF">FAD_0286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7 9">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074061.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N247"/>
    <dbReference type="STRING" id="74969.FAD_0286"/>
    <dbReference type="GeneID" id="16025454"/>
    <dbReference type="KEGG" id="fai:FAD_0286"/>
    <dbReference type="OrthoDB" id="45154at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_uS12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022863">
        <property type="entry name" value="Ribosomal_uS12_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="142" mass="15870" checksum="0C00132934D28218" modified="2017-06-07" version="1">MPNGMNAGKKLMKARKHYAWSDRDYKRRMLDLRRKSDPLEGSPQAKGIVIEKVGIEAKQPNSGIRKCVKIQLIKNGRQLSAFAPGDGAINYIDEHDEVMVEGIGGRMGRSKGDIPGVRFKVIKVNGISLNELVRGRKEKTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N261</accession>
    <name>A0A1V0N261_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit Rpo3</fullName>
            <ecNumber evidence="5">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpo3</name>
        <name evidence="5" type="synonym">rpoD</name>
        <name evidence="7" type="ORF">FAD_0263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="5"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841629.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N261"/>
    <dbReference type="STRING" id="74969.FAD_0263"/>
    <dbReference type="GeneID" id="16025430"/>
    <dbReference type="KEGG" id="fai:FAD_0263"/>
    <dbReference type="OrthoDB" id="84933at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="270" mass="30332" checksum="86C9EC02B427C48C" modified="2017-06-07" version="1">MMKILELKDNFIRFSIDGITPAIANSIRRTLINDIPKLAIENVIYHHGEIRDADGNVYDSSLPLFDEILASRIGLIPLKTDLSMNFRDECSCGGKGCDLCTVTYSINKLGPGMVYSSDIMPVNNPELTVTDPLIPIVELKKNQAMLVTCEAILGRGKEHAKWQATSGVSYKYHRNFHVNKAALDNWQFYKDTCPKSVLSENDTTILFTDDIPCSYLSQLMERDGVVVEEDSTKFIFKFETDGSLKASDVLSYALHRLENRFTALMESLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N274</accession>
    <name>A0A1V0N274_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation-associated GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelA/SpoT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141454.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N274"/>
    <dbReference type="STRING" id="74969.FAD_0287"/>
    <dbReference type="GeneID" id="31675796"/>
    <dbReference type="KEGG" id="fai:FAD_0287"/>
    <dbReference type="OrthoDB" id="5875at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01669">
        <property type="entry name" value="TGS_MJ1332_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000002">
        <property type="entry name" value="GTP pyrophosphokinase (RelA/SpoT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007171">
        <property type="entry name" value="PRK09602.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="2"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="391" mass="44087" checksum="69696699D8D12E1D" modified="2017-06-07" version="1">MLKIGLIGKPNAGKSTLFSAITSIDVDIANYPFTTIKPNVGISFVKDKCPENEINAKCNPREGKCLDGIRYIPVEIIDVPGLIEGASEGKGMGNEFLDNIRDADLIINLFDASGMTDMEGNPSESGHDPLDDIKFVNNEIISWMNGKISKDWQKFARKEDNSPERLDVKILQKAATFGLSEKDVSFIMTKESFPDKLIHWTDNDINRFSEAILKYVKPVFSIGNKLDLLTDDAIKALKDRENKLYMISAEYELLIEKAYNNGYISSDAIDFTFTDKSGEAQKTVLNRIKEKYRNGEIMRFYDVLTSIIKSLGYIVVYPVLDETKWEDKNGNVLPDAYLMKDGDTALDMAYKIHTDIGKNFIRAVNGRTKRVIGKDYKLLNNDVIKIISNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N275</accession>
    <name>A0A1V0N275_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane associated S53 family protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141440.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N275"/>
    <dbReference type="STRING" id="74969.FAD_0272"/>
    <dbReference type="GeneID" id="31675781"/>
    <dbReference type="KEGG" id="fai:FAD_0272"/>
    <dbReference type="OrthoDB" id="56693at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1059"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="6">
        <location>
            <begin position="124"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1102" mass="119376" checksum="58B0CD686CF7FFE0" modified="2017-06-07" version="1">MEYPIKKLLTVTLIFILVISSLAILDTAQNPVISPVNNSDNKNSTSQTIMAYVPTGLKSYVGNQLNSTGIPYSYYGNLLNVNDSTQKGTISYVFSELNRTLGITYFTFNNSNDFIPYIQNPSYQARPYLPSNIYNAYDINYTHNEGYYGNNTTIVIVDAYGDPTLNYDVSVFDNKTGLPPINLTVTTPEGAITSTNSQWASETAIDVEWAHAIAPGAKIDLVLSPGSGSRLLDSVAYAVTHKLGNIISISWGEAESDLSPHTLTSLNNIYEQAAANNITVVAASGDQGANDGTSHLAVNFPASDPYVLGVGGTTLNQISSGQYTQTAWGDIVNGKEEGSGGGFSSYFTTPYYQVAPNYTESYRGVPDVALDANPNTGVLVVVDGATSVLGGTSISTPMWAGIIAIMDQYYGKSLGLVNPLFYKISETKYYKNAFTPITSGSNAGYSAGPGWNPVTGLGTPKVSNLINDTGKIMNGYGTVAVFNNTSYATDISASINVPGNNVEQFNGSTYYYLGFYENQTNYIKFGISTNSTGYYYKYSIYDNGTETRGILPGAPSAYIGIKISGAEIYFTVNNSTVKELNVPVSFSGDYHAVAGAQQDNAKINFVNISKATYSNIDITNATGRINYTGIYTSGYSNMGTDYSNITFSYNSSAKSLTAYMGKEVNKQIYGKAGAVHILYSITFGKNSTLKFSLSNGNSATYAVNGSTKFNPVSLSGGYYNISATESSGVTFYREIHVPTIRVVSVTISSSPSYYSPQYTLIVDHYFGYTSSSKTIDVYELSGNNNATINSTGYFTANASASTIGFLTLKPEKVLVDVFVSNGNATVTLNGVKTNSIGGYHFLYVTPDTTYINATDTGYTSQNQSMNLTPGQNIHISLVLSPKNSSFKAVQGTVENVQYGYGLSNVNITSDGKTIGYTNSSGQFVLFLNGTTNATFHEYLYVNNTTSISPGSSPVVYMSPASVSVLVINFKITYSLPLGFYYAFVSWDKYPSTNFAEYVVAYSNNSLMLNPHTEVISSRGTNFGFIPGLTPGKTYYVIVDAYTPSGSFVSSNEVAVHYTIISYLITLLIFAGIVAYIVFIILFFIRRKKRKKMNEEEYDYFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2C4</accession>
    <name>A0A1V0N2C4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141542.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2C4"/>
    <dbReference type="STRING" id="74969.FAD_0367"/>
    <dbReference type="GeneID" id="31675876"/>
    <dbReference type="KEGG" id="fai:FAD_0367"/>
    <dbReference type="OrthoDB" id="1018at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="177" mass="21148" checksum="9D9635550395C180" modified="2017-06-07" version="1">MRYERIKEFREKYIPYNKIVEKMDLKPDDVIIDMGAGDGFYSKLFADKLKNGKVYAIERNPDVLPHLQRNLMEMKNFEVVNENMCHVDIKGFNKIFFSTVFHDIECREDIIDFMIRNSKKPLNVYLIEFNKKSAMGPPLDIRICHDELNKIFTESGFQPGLHMDFEYNYFDSYYLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2D9</accession>
    <name>A0A1V0N2D9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141518.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2D9"/>
    <dbReference type="STRING" id="74969.FAD_0344"/>
    <dbReference type="GeneID" id="31675853"/>
    <dbReference type="KEGG" id="fai:FAD_0344"/>
    <dbReference type="OrthoDB" id="64524at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36846">
        <property type="entry name" value="PROTEIN VIAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36846:SF1">
        <property type="entry name" value="PROTEIN VIAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="265"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="420" mass="47985" checksum="2869DFA298D2BD99" modified="2017-06-07" version="1">MPENSRSNIDGIPQSSTVYKITKERLVRRVNIDLDKNSADNIKTAASDLYFLFYSGLATVRSEKNKNEFMESVRLRMEYITETKDFKQERAYTQLNDRLSMLYSINFMKALNENAKKNQPRNGNSSNAPDQKTIEKSMEGASKKVEMAHEIEKIVKDKNPGGNIGKKEGMSVESLIDLTDKAMKVDNADKILTLANKLIDIMPRYTKKMRSFSNTGELAGYYKTRHISNVLSRELAMPDEIFYSKLINGFTGKEKRLMSPGSYYVLLDKSGSMYEGDKTLWSRSVALALFRIARSRGRKYYFRFFDNKPHDLLNSPFDVVENILTVESNKGTCIECALKTALRDLQDTKIRSETNTIIIITDGEDKVNMQDYFRKENETKLITVMINGYNEGLKKISTEYMNAKLDESGALELLDVARSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2E1</accession>
    <name>A0A1V0N2E1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9 12">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="3 9 12">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">pgk</name>
        <name evidence="13" type="ORF">FAD_0399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 12">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="3 9 12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141569.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2E1"/>
    <dbReference type="STRING" id="74969.FAD_0399"/>
    <dbReference type="GeneID" id="31675908"/>
    <dbReference type="KEGG" id="fai:FAD_0399"/>
    <dbReference type="OrthoDB" id="6575at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000006">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF23">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 12" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9 10">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="361"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ARD84320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="412" mass="46149" checksum="129C559A1C5A7496" modified="2017-06-07" version="1">MDRSPFYTMDDFDFNGKRVYLRIDINSPINPITGEVVDDTRFIHYLRTINELKNSKVVIIAHQGRPGDSDFVSLRQHAGHLGRLLGRDVLFVDSLIGSAVETAIRNMKNGDIIMLENSRFYSEEILIKDDGTAQKNTFIVRNLSKLFDYFIIDAFPAIHRDQTTLTGFKDIKPNIAGRLMETEIKSIDRFMNSKSHPKLAIMGGAKIRDAIKVTGPFLEKGIVDNIIFGGVAANIFLWASGIDIGKRNMEFIEKQDKNYKKLLEECKSLLSRFSDRIYLPEDFMLNPLQTEIKTGEKVQDDQLLADIGFESIKTFSSIIEKAKNIFLNGPMGMYEINEYSLGTREIFNAVSQSPASKIVGGGHTINAINEFGLSDSMGYISTGGGALINYLSGEPIPVIDSLVYNRKKFGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2F3</accession>
    <name>A0A1V0N2F3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HTH DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887369.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2F3"/>
    <dbReference type="STRING" id="74969.FAD_0350"/>
    <dbReference type="GeneID" id="16025515"/>
    <dbReference type="GeneID" id="31675859"/>
    <dbReference type="KEGG" id="fai:FAD_0350"/>
    <dbReference type="OrthoDB" id="7592at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="219" mass="23689" checksum="57E4A2B0F2878F6D" modified="2017-06-07" version="1">MVKYEIRGGDVQYLHATLEAGESAYIEPGHLIYKTPGARLDTGTGGLRGAFSHMLAGSAVFLLKVDGPGNFGSAGFLPGKVFEIKLNNNSIFAEFNAFLCMDSTIKYSTKFAGFWQAIFGGEGIFLEEFSGTGSVMLHGHGQVIEYELKDGEEIQAELSHVLAFESSVSYNVSRIGGIKTMVLGGMEGEGFFFANMRGPGKVWLHSISLLELSAKLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2F5</accession>
    <name>A0A1V0N2F5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0368</name>
        <name evidence="2" type="ORF">HLB00_03495</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000112">
        <property type="protein sequence ID" value="NOL59898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887388.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2F5"/>
    <dbReference type="STRING" id="74969.FAD_0368"/>
    <dbReference type="GeneID" id="16025534"/>
    <dbReference type="KEGG" id="fai:FAD_0368"/>
    <dbReference type="OrthoDB" id="56528at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="209" mass="23644" checksum="179BB7E8A457C6F0" modified="2017-06-07" version="1">MVNTAEIVRKYIDGNPDLKDYLNRGIINISALSREIMANTGIEDFDATMAALKRYRSNGQAVYNSEILDRSNLEMSSNISLIVIKKSYESLKIITGIIGNLKKLNSINLVETKNSFSLIGDNETIKGFSNFFSDEQIIEHKKDLGQLSIISPEEIEKTKGYINFITMLLYRAGINILQIISFYSDTIIILEEKDLTDAFKIISAKMIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2F8</accession>
    <name>A0A1V0N2F8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141541.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2F8"/>
    <dbReference type="STRING" id="74969.FAD_0364"/>
    <dbReference type="GeneID" id="84218862"/>
    <dbReference type="KEGG" id="fai:FAD_0364"/>
    <dbReference type="OrthoDB" id="64936at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10795">
        <property type="entry name" value="GH57N_MJA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052046">
        <property type="entry name" value="GH57_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36306:SF1">
        <property type="entry name" value="ALPHA-AMYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36306">
        <property type="entry name" value="ALPHA-AMYLASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 57 N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="377" mass="44517" checksum="4CB4381A7E4639F2" modified="2017-06-07" version="1">MENIAFYFELHQPLRLRPLKIQDRPDKMGIFWEEQNRDIFKRISEISYIPATKLLMESGIKSTFSLSGTFIEQALKYSPETIDVIDDYVKSGLCELMGETYFHSLASIWNEDEFKYQVNEQMHSIKSIFNYSPVSFRNTELIYNNRIAEMARDMGFRNILAEGTDEVSGRYSPNFRYLSPSGVNLYLRNYPMSDNISFRFSNTAWSGYPLTADKYIQWIQNSPGDIMNLYMDYETFGEHQRKETGIFDFVHYLGKYIEQYGMETLKIDEIQAKFSVKDTVSIDKTISWADTRRDLSAWLGNKMQNEAFSRLKHCEDCPDKKLWRYLQTSDLIYYMSMGEPEDFTVHEYFNPYRSPYLAFIYYMYALDNVCENAGKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2L6</accession>
    <name>A0A1V0N2L6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">H/ACA RNP protein Gar1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gar1</name>
        <name evidence="1" type="ORF">FAD_0419</name>
        <name evidence="2" type="ORF">HLB00_04875</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000166">
        <property type="protein sequence ID" value="NOL60169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887475.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2L6"/>
    <dbReference type="STRING" id="74969.FAD_0419"/>
    <dbReference type="GeneID" id="16025621"/>
    <dbReference type="KEGG" id="fai:FAD_0419"/>
    <dbReference type="OrthoDB" id="60264at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="70" mass="7823" checksum="6C0A30981FF1C9CA" modified="2017-06-07" version="1">MKTECTIVHKFNNEVLLRVNDCIGLHNKLVNEYDAVIGKVTKILGPVSGPYALAYIASKDDNIQKVYIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2M2</accession>
    <name>A0A1V0N2M2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps3ae</name>
        <name evidence="4" type="ORF">FAD_0429</name>
        <name evidence="5" type="ORF">HLB00_08220</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000306">
        <property type="protein sequence ID" value="NOL60812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887485.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2M2"/>
    <dbReference type="STRING" id="74969.FAD_0429"/>
    <dbReference type="GeneID" id="16025631"/>
    <dbReference type="KEGG" id="fai:FAD_0429"/>
    <dbReference type="OrthoDB" id="30639at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00359">
        <property type="entry name" value="Ribosomal_eS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030838">
        <property type="entry name" value="Ribosomal_eS1_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003142">
        <property type="entry name" value="PRK04057.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="209" mass="23853" checksum="F5A7AE252F270FD5" modified="2017-06-07" version="1">MADRRRSTTKDKWKEKSWYTIVAPSYFGEKEIGLSPSADPKYMINRTIAVPVSTFTGNFKKASSMVLFQIDNCEGKRCTTKFIGHEVSDDTIRRMVRRRRERLDIVTDVKTSDLYNVAVKLVLVADQKLTGTKRSEIRSTAVDYILNKAKEMDLGTFANYVIGDAVYGDFVNSLKDVYPIKKIEVRKTEIGKRDEVPDKEQEPVEAVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2P0</accession>
    <name>A0A1V0N2P0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141599.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2P0"/>
    <dbReference type="STRING" id="74969.FAD_0444"/>
    <dbReference type="GeneID" id="84217029"/>
    <dbReference type="KEGG" id="fai:FAD_0444"/>
    <dbReference type="OrthoDB" id="55924at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="181" mass="21630" checksum="DE95D189016C5BF9" modified="2017-06-07" version="1">MIIISTLGKMHENTIGYGYEDLITYLGELKVKNLIITYTSRHNYNMKQDEFREIKLLENSFNVFFPEIDYDKYNELLTRYSLETHNAEEVTKKNIVDIIETVINSYLKGYWKSPETVNSEVTDSIYRVKNKFIQSVNPEYIEKYWLPFHTDVYNYIEKNKSNYDAVISDVESAFFYKEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2V9</accession>
    <name>A0A1V0N2V9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase, short-chain specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0515</name>
        <name evidence="8" type="ORF">HLB00_00530</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000014">
        <property type="protein sequence ID" value="NOL59325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887573.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2V9"/>
    <dbReference type="STRING" id="74969.FAD_0515"/>
    <dbReference type="GeneID" id="16025719"/>
    <dbReference type="KEGG" id="fai:FAD_0515"/>
    <dbReference type="OrthoDB" id="275197at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="202"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="328" mass="36263" checksum="CC739A511089CC3D" modified="2017-06-07" version="1">MKEENNILKETVAEFCEKNLDEKKIENEGISKATTELLASQGFLGATIPAKYSGSELDNTSYEIILEEISKYSPSVAMKIFILNSLYYPSVKGTSAESTLTDAASGKLDVAVDVIGNGSDLKENSGKLSGTLKSILGTDAENIILFNGKTSMVSGKFKSAARDFMGFRGMKFGDVTLDNSITILDQKSRKDKIIEESYGPLSAIALGMISGALQKAIDYTSVRKAFGNYLKDFEPISFRLSRFRSIESVLRSALYGGVDPYYAFNLAMESMVEIARYSVNTHGGYGYFQDFGVEKFYRDSIVMKSIFYGNQELKKLAEHVYSEKINFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2X5</accession>
    <name>A0A1V0N2X5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0576</name>
        <name evidence="6" type="ORF">HLB00_05340</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Berkeley</strain>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000178">
        <property type="protein sequence ID" value="NOL60258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887633.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2X5"/>
    <dbReference type="STRING" id="74969.FAD_0576"/>
    <dbReference type="GeneID" id="16025783"/>
    <dbReference type="GeneID" id="31676080"/>
    <dbReference type="KEGG" id="fai:FAD_0576"/>
    <dbReference type="OrthoDB" id="56199at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204:SF37">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR YODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="113" mass="12939" checksum="F9BB9CCD11EB0DA5" modified="2017-06-07" version="1">MKNSRAEACMIYDNEKTICIDTSLPVFDLLGKRYTLFILGVIGNNNTRKNFNDIYNSIPGSNRTIIARRLKELTDAGIVKRCRKEVVTYELTEKGQDIRKGVICFLDSIDRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Z3</accession>
    <name>A0A1V0N2Z3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional phosphoglucose/phosphomannose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0562</name>
        <name evidence="5" type="ORF">HLB00_00685</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000019">
        <property type="protein sequence ID" value="NOL59355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141690.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Z3"/>
    <dbReference type="STRING" id="74969.FAD_0562"/>
    <dbReference type="GeneID" id="84217161"/>
    <dbReference type="KEGG" id="fai:FAD_0562"/>
    <dbReference type="OrthoDB" id="10151at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05017">
        <property type="entry name" value="SIS_PGI_PMI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05637">
        <property type="entry name" value="SIS_PGI_PMI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035484">
        <property type="entry name" value="SIS_PGI/PMI_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02128">
        <property type="entry name" value="G6PI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006423">
        <property type="entry name" value="PRK08674.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="305" mass="34611" checksum="DE954AFF7A11EB03" modified="2017-06-07" version="1">MNFLDEIKNLKEQIKSKDKFDINFNFDNIVISGMGGSGIVGNIFQEYYTSIPVISIGDYGIPGFVNEKTLFIAVSYSGNTEETLSNVEDAKKKGAHVRAITSGGKLATIVEKSIIIPSGIQPRSALGYMLMPLFNTFAPIDDAIVNQTYGILDDMDKNHSDIKSEAFKIYENSSIPIIYGSKPFKSVAYRWKTQFNENAKTFAFYSYFPELNHNDTMPLKSAYRRDEYLFYAFESDNARINQRIGITEEITGEQFTVVKSPSQDYFSKLFYLIHYADYLTYELALVRNVDPTDVSTIEELKKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N304</accession>
    <name>A0A1V0N304_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141692.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N304"/>
    <dbReference type="STRING" id="74969.FAD_0563"/>
    <dbReference type="GeneID" id="31676068"/>
    <dbReference type="KEGG" id="fai:FAD_0563"/>
    <dbReference type="OrthoDB" id="10943at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041120">
        <property type="entry name" value="RqcH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="2">
        <location>
            <begin position="417"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="615" mass="70068" checksum="5B776DFCC3630079" modified="2017-06-07" version="1">MKLKESSLDFHAFIAIYGDTILNSFIKKVYQVNQKEFVLQIYRSDVKKRDFFISLNKGIGFYDAEKPEEATQLSMLFRKQLSEKRIVGIEQINFDRVVRITLHTGQEIILELFGGGNLILTDNGKIVFAMEQHVYKTRKVQIGEEYIPPAVINPVADLETFSGILDKSSASIVKTLATRVNLGGEIAEEALYRANIEKDKMPSEIKDQYQILYDSIMGIIGESSKNNAFYYEAEELLSPVLLTAINKEPDVKFEDFNEGIGFYLKHYPENEKNKSSVERRIESQRRSIEEFNKLMQVYNEFGNYLKMSFPQLQKLINIVYNNVKRNTPEDFKYMDMDISDINPGKNTFAINYNGTKIILNYRESAGNNINYVFNTAKDYKGKIEGAEKAIEETKKLIVKEKQKAGKKKRVKYWFESYHWFISSSGNMIMAGRDAKTNEKLVKKHMSDDDIYVHADLYGAPSTVIKHEGIEITEETIKEACIFSISLSRAWPAGIGSGTAYWVYPSQVSKTPESGEFVSKGSWIVRGKRNYVLNIPLELKVSIVDYKGNNIPMISPAETRTESKKWVLIKPGNEKRSVAAEKIAKILGIEKSEIESILPPGGSIVVENSKEIKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N313</accession>
    <name>A0A1V0N313_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hydrogenase 4 subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_0582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ARD84494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="31676086"/>
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    <dbReference type="OrthoDB" id="19089at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Proton_antipo_M"/>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="440"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="387"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ARD84494.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A1V0N321_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">Dioxygenase ferredoxin reductase component</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0650</name>
        <name evidence="8" type="ORF">HLB00_03635</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
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        </lineage>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
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        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
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            <name>[2Fe-2S] cluster</name>
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        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="111" mass="12276" checksum="63CEE2924B2617CA" modified="2017-06-07" version="1">MESKPLCKTTEIEEGKSREFEVGNKKILVSNVGGKFYAIDALCSHMGGDLGKGKSEGHDVICPKHHARFNVQTGKVDKNINGFFKAMTRKEATDLKSYEVKENDGELSVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N336</accession>
    <name>A0A1V0N336_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">Carbon monoxide dehydrogenase alpha subunit</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">FAD_0652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84562.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N336"/>
    <dbReference type="STRING" id="74969.FAD_0652"/>
    <dbReference type="GeneID" id="84217254"/>
    <dbReference type="KEGG" id="fai:FAD_0652"/>
    <dbReference type="OrthoDB" id="37184at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000003">
        <property type="entry name" value="Carbon monoxide dehydrogenase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Xanthine dehydrogenase iron-sulfur subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051452">
        <property type="entry name" value="Diverse_Oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44379">
        <property type="entry name" value="OXIDOREDUCTASE WITH IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44379:SF5">
        <property type="entry name" value="OXIDOREDUCTASE WITH IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="159" mass="17582" checksum="B0267E5F52E2A123" modified="2017-06-07" version="1">MIVNIKVNGEEYKKDVEPRTLLATFIRDDLKLTGTHIGCDTTNCGACTVLMDGRAVKSCTVLAAQADGHEIETIENEKDADLKKIKESFVEENGLQCGFCTPGMIMTSLYMLRNNKKPDDDYIKSNLAGNLCRCTGYVSIINSIKKASEKINTEKVRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N369</accession>
    <name>A0A1V0N369_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="3 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 17" type="primary">hemA</name>
        <name evidence="17" type="ORF">FAD_0680</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 13">
            <text>(S)-4-amino-5-oxopentanoate + tRNA(Glu) + NADP(+) = L-glutamyl-tRNA(Glu) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="3 8 13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141784.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N369"/>
    <dbReference type="STRING" id="74969.FAD_0680"/>
    <dbReference type="GeneID" id="31676181"/>
    <dbReference type="KEGG" id="fai:FAD_0680"/>
    <dbReference type="OrthoDB" id="4562at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019353">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process from glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="entry name" value="Glutamyl-tRNA reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43013">
        <property type="entry name" value="GLUTAMYL-TRNA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43013:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="Glutamyl tRNA-reductase catalytic, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="Glutamyl tRNA-reductase dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA reductase N-terminal" evidence="16">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="15">
        <location>
            <begin position="157"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation" evidence="14">
        <location>
            <begin position="290"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="167"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ARD84588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="402" mass="46108" checksum="66283C46AB688885" modified="2017-06-07" version="1">MGDIELLSWNYKDTPDTFSEIIKHDYRYFESMMESRSIKNYVILVTCNRIEIYFRPEQILMGSIEGSLYLEYPESVKHLFMVASGLESMAIGENDILRQIKSSFDIASKRGKLDKFLSYTFRKALSVGKDVRTLTDISHGKTSLSSISLDIIQNQYGLAGKKLCIIGTGKMATALLNYLAGSKTIITVAGRSVEHARELAIKYGANYSDISNIPSLIKSNEIIIVATSSKNYIIRAEDYSNINGNKIMIDLSNPPNIEQAMNEYIAFYDLDRIYSISKETREHRKLEIKKAEEIVENELTLYTSKINEMKSDDIIAAFYKFANQIKQDELEELARKTDIKESQMEIIDIMMNSFTKKLLAPYTDSIKNFIKNNENYSYILEEYDTMLGNMMRKGKKAEIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N379</accession>
    <name>A0A1V0N379_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0615</name>
        <name evidence="11" type="ORF">HLB00_04660</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000162">
        <property type="protein sequence ID" value="NOL60126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887673.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N379"/>
    <dbReference type="STRING" id="74969.FAD_0615"/>
    <dbReference type="GeneID" id="16025822"/>
    <dbReference type="KEGG" id="fai:FAD_0615"/>
    <dbReference type="OrthoDB" id="275197at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000004">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000026">
        <property type="entry name" value="Acyl-CoA dehydrogenase medium chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="225"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL60126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="377" mass="41782" checksum="9CA068990D1A24FF" modified="2017-06-07" version="1">MLNENETNVLKYVRELAETKIKPRAREIDEKMEVPEDIIQAMRDMGLFASYIPEKYGGYGLSFPFLVNVIETISEACPSTALVLDGALTLFAEPLIMFGSEELNKKYLTEIAKGAVGGLAITEPGSGSDAASISTRAEKCEGGYKITGTKTFISNGRIAKFFVMDASTDKSKGYKGITTFVVDGNAPGLEISRDIHKMGIRGSSTVELNFHEVFVPESNIVGEYNKGFSVIMDTLDAGRIGIAAQALGIARSAFHEALEYINTRKQFNKKIIDFQGIQFMIAEMESRIKASDLLIREAAEKWQNHEDTVELSSIAKMYASDTAVYVAERSLQLFGGYGYTTDFNAERHMRDAKITQIYEGTNEIQKIIISREIMKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3A7</accession>
    <name>A0A1V0N3A7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3A7"/>
    <dbReference type="STRING" id="74969.FAD_0672"/>
    <dbReference type="KEGG" id="fai:FAD_0672"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="93" mass="10657" checksum="690EC66D84C10A9C" modified="2017-06-07" version="1">MSQGLEDLNMENSLQNFIDLPLILSNASSVFILEYIPVVAKSSWPSIWRRLSKSMSFLIILCAYVCLHLCQLNSFIPVFFLISWSYLSFLGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3C5</accession>
    <name>A0A1V0N3C5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nickel import system ATP-binding protein NikD</fullName>
            <ecNumber evidence="10">7.2.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FAD_0688</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ni(2+)(out) + ATP + H2O = Ni(2+)(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15558"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.11" evidence="10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940606.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3C5"/>
    <dbReference type="STRING" id="74969.FAD_0688"/>
    <dbReference type="GeneID" id="31676189"/>
    <dbReference type="KEGG" id="fai:FAD_0688"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015413">
        <property type="term" value="F:ABC-type nickel transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03257">
        <property type="entry name" value="ABC_NikE_OppD_transporters"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000016">
        <property type="entry name" value="Oligopeptide ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050388">
        <property type="entry name" value="ABC_Ni/Peptide_Import"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008453">
        <property type="entry name" value="PRK11308.1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43297:SF13">
        <property type="entry name" value="NICKEL ABC TRANSPORTER, ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43297">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORT ATP-BINDING PROTEIN APPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="364"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD84595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="705" mass="79310" checksum="D20C613B423F4971" modified="2017-06-07" version="1">MMENIENEYNYTGNTILKVENLNVNFKTFNGTVKALRNINLELKDGEILGILGESGSGKSTLALAIMSLLPDNALIDGSILFKGNNYINESKKLTRKQQKEIDAKLRNMRWKDISMIFQGAMNSFNPVYTIGKQIGEVFRIHTNLSKEEINKKVIDVLKIAGLTPNVMKSYPHELSGGMKQRAVIAMALALNPNIVIADEPTTGLDVITQAEIISQIKKLRDTGLIKSMIIISHDIGVVSQLADHIAVFYAGQIMEYGKSRDIYLESKNPYTIELLKSYPSILHAKNHVEGIPGRLPDPTNLPAGCKFADRCYMAQDICRKIEPEKAYVSGEHYSYCHFVNNIQANSLTSNIDTNFSPGSYNIITVQDLTKYFYLKNNMMSSLYSKNNAHVRAVDHVSLDIKKGEILGIVGESGSGKSTLARLLIGILKPTSGDIEFFFDETQHANVSKLKRKHEDYKEFRKNTQMIFQDPFDSLNPKMTVFNIVSEPIIGHNALKDYSEMEAMVNEALAKSDLYPPEAYLDRYPYELSGGERQRVGIARAIVLKSNFIIADEPTSMLDVSLRASFMNKLNEIRKKDQLTIVYISHDIASVYYLSDRIAVMYLGVVVEIGDANEIITNSLHPYTKALIKSVPSPTPEWDPGKIDIIGEIGNSINVPKGCRFFNRCVYRKDICKDTPPPVKGDSNHWYRCHFTEDELVSIKNERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3G7</accession>
    <name>A0A1V0N3G7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141977.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3G7"/>
    <dbReference type="STRING" id="74969.FAD_0785"/>
    <dbReference type="GeneID" id="84217405"/>
    <dbReference type="KEGG" id="fai:FAD_0785"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="198" mass="22766" checksum="3C23CECF16DAA3B3" modified="2017-06-07" version="1">MIRKLYYFLSVFAGSIVLGLIVSLSSRNFIAVFLLYTAIFFILGVSFTVFPFVYYNHFSELRVLSKIPKYPPGQIINIMDATATFNVSIKNNNFDIIQGLEHEKYIDAKVAFVGHFIEFYQYSHPYVLSYIPFLKINSLSITGIRQGKKSHSIINPELPSMIKCNYFEILTDSGIYRIIVLQISTDRFIDAIQNSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3I6</accession>
    <name>A0A1V0N3I6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS605 OrfB family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141997.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3I6"/>
    <dbReference type="STRING" id="74969.FAD_0807"/>
    <dbReference type="GeneID" id="31676309"/>
    <dbReference type="KEGG" id="fai:FAD_0807"/>
    <dbReference type="OrthoDB" id="57553at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="6">
        <location>
            <begin position="201"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="7">
        <location>
            <begin position="338"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="461" mass="54039" checksum="03EBBE09AE427DBD" modified="2017-06-07" version="1">MIEEKRNKIKNSLRITRERRKTQDVIILKLKIDNDKLNNNTIKALNTIFLEAKWLYNYVINKEFNNDIFNIDPKIKNVNVYVKDHYEKRKINYLSSQMKEEIINRAIDNIRGLHKLKEKGLKIGKLKFKSFITSIPLNQYTITYKIINNNYIKIQNIKQLLKVNGLDNLECYYEPASALLINKNSNYYIYITAYRNKYILEKPVNNQKIISFDLGIKNQLTCSNGSILNYNIPKSKKEIRLQRSLSRKAKYAEGSKNKLSKKQSKNYYKTKNKLNREQNKTTNKRKDTINKITHYLTSNYDIVITQNDNIRGWKHHYGRKIESTGIGGIIDALKHKASTLILLDKFIPTTKECSNCHNKYNIKLDERIYQCTNCGFIIDRDYNSALNMIYYGIIKLNELLKIKNKKLNNYFKKYNINLNVPMECRELTPVEIIASGFEGLNISPYVKLSMVNEAGSLYALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3J0</accession>
    <name>A0A1V0N3J0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Microsomal dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141920.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3J0"/>
    <dbReference type="STRING" id="74969.FAD_0755"/>
    <dbReference type="GeneID" id="84217375"/>
    <dbReference type="KEGG" id="fai:FAD_0755"/>
    <dbReference type="OrthoDB" id="26221at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="298" mass="33211" checksum="9915894684944750" modified="2017-06-07" version="1">MKFIDLHEDIAYSSMYRDVIHGTGQSGIDMLKRFPGSIIFSVVFPHVNMQYGEEYGTSIPNTTLAYQQLNYYREISKKYGINLIEGNKPVDSELNFLLSMEGTDILNRPEDIEMFHSMGLRNLGLTWNYDTKFASSCYSKKDYGLTGSGEDLVKICNSYGIIIDLAHAGKKTILDTCNVASKPVLDSHTNFKVLKDHPRNIDENSIKAIVDTGGVMGITGIRPSLHTPDINGMLESITYLGDNFGWKHVSLGTDFLGIPEPPDGFTDVNAIEKLKEMIGTHSEDVLFNNALRVIKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3J5</accession>
    <name>A0A1V0N3J5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S protein assembly chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hscA</name>
        <name evidence="6" type="ORF">FAD_0761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141932.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3J5"/>
    <dbReference type="STRING" id="74969.FAD_0761"/>
    <dbReference type="GeneID" id="84217381"/>
    <dbReference type="KEGG" id="fai:FAD_0761"/>
    <dbReference type="OrthoDB" id="383498at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="473"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="565" mass="61868" checksum="C6BFBA897044238C" modified="2017-06-07" version="1">MFSIGIDLGTSNTSAAVALISGSEYKTIAIPLSGKKAGSSLKSSITFGGSDIMFTGTDADKMLKKYSGGNVSGFKTRMGSEYLYRTGEKFHSPVELSAIILARVKNIAEDYMHDRVKDAVIAVPAYFNNNQRNATREAASIAGIKVKQFVSEPAAVAISYWNSASKTEAKNILVFDMGSGTTDVSIVRAQGKDFRVIATSGNTGLGGTDMDRRIEEMMKSFLRTNGISPYPPDLRKEAEKLKIYLSNHEAGDSLLGSTKIKYTMDSKQLDSIVSDMLPEIYRCIDMAILNSGIKRNELDTVIITGGPTKIPFLFHSIENYLSTRAVKHGKFDTAVSTGAAILASGFIRMGTGEISKIKVSDVVPISLGSVTRNDIVVTMIPANTPVPCKATRPFTTIRDYQSEIEVKVVQGERPLGTDNIVLGHFTLSGIKPAPRGEVAIDVTYSVDKNGILTVSAKDNDTGAIKEIKISETMQHSQEEIKEMKEAVKKYFKVDAERKKMAEIMNRSEQLLHELKGIANKQLLSETKYYNINTDILMVSRAIKNNNVKLLSQLLAKMDKEYSLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3L2</accession>
    <name>A0A1V0N3L2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TA0938 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142052.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3L2"/>
    <dbReference type="STRING" id="74969.FAD_0842"/>
    <dbReference type="GeneID" id="84217462"/>
    <dbReference type="KEGG" id="fai:FAD_0842"/>
    <dbReference type="OrthoDB" id="33200at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021585">
        <property type="entry name" value="Ta0938"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11494">
        <property type="entry name" value="Ta0938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11279" checksum="43D7B5AE14D902EC" modified="2017-06-07" version="1">MKTNNTEGCALCNATWGEYYREIEGENMFFCCNICADILEGMVNKVKDETGWNKIDYLELHGNYSSGRTCTAKSGNEEFKYYYRTYGDGRVMEYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3L9</accession>
    <name>A0A1V0N3L9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0788</name>
        <name evidence="5" type="ORF">HLB00_02080</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000060">
        <property type="protein sequence ID" value="NOL59622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019841797.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3L9"/>
    <dbReference type="STRING" id="74969.FAD_0788"/>
    <dbReference type="GeneID" id="16026007"/>
    <dbReference type="KEGG" id="fai:FAD_0788"/>
    <dbReference type="OrthoDB" id="85195at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="67"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="229"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="281" mass="31972" checksum="83C74BC5C5DE7AC6" modified="2017-06-07" version="1">MDYKVSDIMTRDPLCYTVPSAISDVIQVLIKNNITGIPVKDNQNHYQGVITRRDIFYNPDETQTALVMRKAPTVNENDSINTAARQLYTQKKRHLVVVNDKNEVTGILTPQNFLNIIKEKYGKVKVKEVLEYISVPIWEDTPLSVALLTMNLSQIYSFPVVNRGGKFTGLVTDRDIFDKVKMYQTIESSESGIADDEDPWSWDGIKNVFTYFIAKSNITVPDIPVKKLMVGSPKVIYLESDLEDAVKLMSSENYNQLPVLTGHGEIYGMLYDIEIMKIFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3R1</accession>
    <name>A0A1V0N3R1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin biosynthesis MoeA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Y</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142145.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3R1"/>
    <dbReference type="STRING" id="74969.FAD_0898"/>
    <dbReference type="GeneID" id="31676401"/>
    <dbReference type="KEGG" id="fai:FAD_0898"/>
    <dbReference type="OrthoDB" id="31371at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="3">
        <location>
            <begin position="191"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="409" mass="43876" checksum="4BD0BF69B2B49B9A" modified="2017-06-07" version="1">MAKHIMKGFDSLLPYKSALSIFKGEKWTYPDSIQLTLDSAGGKISSGEIISTVNIPDKNKSAMDGYALKSIDTLNATPANPVKLALKGTIAAGDTPEEIVKDGTCMEIYTGSIMPEGSDAVARAENCEVIGNCIYVYSSVNKGENVAPAGEDLKTGDTILGKNSLIYPQNLAALKSIGISKVNVYGNISIGVINTGKELINKQIENSTGMLLRTFYTSSFTETIDGGIVDDDEKSIALAVRSMIEKCNILIVTGGSSLGRRDMTTDALSGEGKMLFSGVSIKPGRTIGLFNIKNRPVLSVSGLPVAALLSSMIFVDSYIKNIYRVDYIHRASSILDESIHNRAGFTTFQIARTYAIDGELHSIPLNTKVSGNLSAIIKGNSIIKIDENLEGIPQGSRVNIYIIGDIKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3S0</accession>
    <name>A0A1V0N3S0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="13">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">cysS</name>
        <name evidence="15" type="ORF">FAD_0827</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>tRNA(Cys) + L-cysteine + ATP = L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="13"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142028.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3S0"/>
    <dbReference type="STRING" id="74969.FAD_0827"/>
    <dbReference type="GeneID" id="31676328"/>
    <dbReference type="KEGG" id="fai:FAD_0827"/>
    <dbReference type="OrthoDB" id="9445at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000130">
        <property type="entry name" value="Cysteine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="14">
        <location>
            <begin position="14"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="13">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="13">
        <location>
            <begin position="265"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD84727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="456" mass="53439" checksum="69C53D263468AC1B" modified="2017-06-07" version="1">MIIHNTLGQKDEDFKPMHPGRINMFVCGPTVYDHSHIGHARTNIFFDVIAKYLRARGYSVFYLQNITDIDDKIINRAAEEGKEYSEVADHYFEEYKEIMGKLRIDSINYYARASLYIDEIIGQIKKIMEHGYAYETADGVYFNVRKFSDYGELSNQNMDQIRENARGVIKEEKKSPEDFVLWKKMKPGEPFWESPWGKGRPGWHIEDTAITEAYFGSEYDIHGGGNDLIFPHHEAEIAQMRSVSGKRYLARYWIHTGMVNINKEKMSKSLKNFIQTKDILKSYKPEELRFAMINSNYNTVIDYSTQLMESSKDAVERINIFYNKMKELNSTEGSYNIDAEEIINHFNAVMDKNFDTRSLIREFLAFISDANKNMENISSAAASKLIHIVEYVDSFLNIIYRKQNQESNIMDIIIDIRNHARSRKDYAISDYIRKKLEENNIYIEDNGNKTIWWIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3T4</accession>
    <name>A0A1V0N3T4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyl transferase AbiEii/AbiGii toxin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142044.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3T4"/>
    <dbReference type="STRING" id="74969.FAD_0836"/>
    <dbReference type="GeneID" id="31676336"/>
    <dbReference type="KEGG" id="fai:FAD_0836"/>
    <dbReference type="OrthoDB" id="359531at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.620">
        <property type="entry name" value="JHP933, nucleotidyltransferase-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="31262" checksum="03A9BFC6FA7323D8" modified="2017-06-07" version="1">MDNIEIKKWKDYTKIMGFKNSYSTEKDYLQEIVLNSLFYISPVNDIIFIGGTAISKVYGSGRFSEDLNFIFDKSYDTTDVENRVKKAIKEVNNFYPIEYSTLKRRDMLRYNLKIKGPFYEMSHSVRAIQTIKLDINLYVRPFYNPKKVLRTTIYPEIRPYFLLTLEAEEFAAEKIKAIMEKKNPVARDLYDLWLLITKYNVKINIEMINYKLQKYTQVQGFNIDEFLEKVISIGDIWNTEMESLLNVIIPFDAVKDTVIDYIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3U8</accession>
    <name>A0A1V0N3U8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142222.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3U8"/>
    <dbReference type="STRING" id="74969.FAD_0948"/>
    <dbReference type="GeneID" id="31676452"/>
    <dbReference type="KEGG" id="fai:FAD_0948"/>
    <dbReference type="OrthoDB" id="60294at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="52207" checksum="9E94C3B736CF5D09" modified="2017-06-07" version="1">MKVIIDCESLTDREYTKLFNSLKKLDFELLDINGNSLDENYNIIRSENGGEYSQLITLFKEHSVNYIISNNQDMVFNFTNTELKDNILTLLEAYNYLLPQLDSDNNFSLKSPSVADLDINDRIFDTLKANYPEFTEWFMRRQMEKRPCSVFYDANHNIAALMIYKLENEEIKLQKNNIPKRRRLKISTFIVTMNGYKFGEALIRIAVEECIKENVNCMYLTHFVDENDSLVYLIKEYGFTGAGLNDGGEHIFIKSLRPERANNNQITDFVKFNMKYFPSFYDGPKVNKFIIPIKWTFYKRLFQSPMEILQGYPLSSINSIEKAYISHSNISSINAGDILLFYISHKKSSIFDLGIAKIIRSENDTQKISTIIGKRSVYTEQELKDDSGKRLIIKFNHIFKLKHPVKYERLFKENILNGPPQSILQIDDVKYEKIKKIGDIDESFTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3X3</accession>
    <name>A0A1V0N3X3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">External multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142173.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3X3"/>
    <dbReference type="STRING" id="74969.FAD_0912"/>
    <dbReference type="GeneID" id="31676415"/>
    <dbReference type="KEGG" id="fai:FAD_0912"/>
    <dbReference type="OrthoDB" id="27380at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="528" mass="59312" checksum="9E2211827EBBB851" modified="2017-06-07" version="1">MSHLKVITNIASKLKNDPYFLWIFIVSLVFSILFTVYSSMAFNLVEMTGWDMGIYMQALSSGISGHLFYSALVPGSYLAEHFSPILFILLIPYYLFPSAYTLIVLQSFAIGFSTLVLYLLSKEILQRIGIIKAGKWLNASTISFIISMAYIMSPLTESPVFFDFHLMVFLPLFFFLAIYSFIKKKYILNIIFLALIVSIHSTFVSIALMAILFEIFLNRTFMITSNHSVVRGSIYFFISLAILVPYFIFAGILKGDIAGVPVSVLSIHVSGSVGPTTLVIDTFTNPVLVLHLLVQNYILKLTLLFFAFGGFAFLFIRYPASILTFVPYIIYSMFSTYPSYYTIGYQYTMIFIPMVAVSGVVGMYILVKSQMHRPSFKLQLRMALSVIIIIAILGFSIATPIVSGDANSNSIYTSATHYGNDTYMNQVIFEHEIANSIPKNATLVTGNGLFPLFGNDLNATAFPYTTDVIIKGDYYQYLVENQNSIWSSEPTHISGTNISLNMLEHEYMASGNYTVYAHNYGIIVLKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3X8</accession>
    <name>A0A1V0N3X8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142266.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3X8"/>
    <dbReference type="STRING" id="74969.FAD_0971"/>
    <dbReference type="GeneID" id="31676470"/>
    <dbReference type="KEGG" id="fai:FAD_0971"/>
    <dbReference type="OrthoDB" id="196752at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38133">
        <property type="entry name" value="SLR1429 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38133:SF1">
        <property type="entry name" value="SLR1429 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="280" mass="32131" checksum="5D9C3DD9DD5559AB" modified="2017-06-07" version="1">MARRKYYDDYYRTAIKTTGGMKVKSKKGDIGTKWWSKRFIAILNSYGWETRLQRGKRYARVGQVLRVNIDSNVVSADVQGSRKKPYRISIEFPRLGDSAWEKIVKQIISTKGLVAGMLAGEVPSELENAFKQGGASLFPQSGDEINMNCTCPDYAIPCKHIAAVFYILADRLDDDPFLLFELNGKRKEELISAISKNNDGNIPENKENNNDKSVAVEELNNFWKPPDLHIPVENVRKNTLSPLKKYPLPMEFNDPEIQYMLELYYNRINENLKKIKEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Y9</accession>
    <name>A0A1V0N3Y9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN-domain multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142201.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Y9"/>
    <dbReference type="GeneID" id="31676441"/>
    <dbReference type="KEGG" id="fai:FAD_0937"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="362" mass="40926" checksum="AAB894537C5E3A0B" modified="2017-06-07" version="1">MNEKNQFIEDLYTYFPDDWKILFKDYDQTKKVISNVSRELPPDAYEFIREHMIDQLFFNENKQPAPKLKFVVDSNIIVKDAFRVGSGKFSSTERIFSSPFVKLYAPRKIEDEVYEQITRGLPEKCSMDLALQQAKKLLSKIEIVDDNELNIENLELSEFRDKYNNDVHFLKVGIGLGIDKIITRDKKAFNGISTMKRYELGTAVELIVSVEAGSLSLSIVTGAAYVGTEAIYFLLSILYKVFTELLLFIISITTFGISGFISLLGKLPAWVGYIAIGSIIGTIIAFSFSKNLRNQAVNIVDDLSEWIKTHSIYAKDALISLIKGTVDLSTMLKEDLGPYFINAGNAMISSIYDMVDILNKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Z1</accession>
    <name>A0A1V0N3Z1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951120.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Z1"/>
    <dbReference type="STRING" id="74969.FAD_0913"/>
    <dbReference type="GeneID" id="31676416"/>
    <dbReference type="KEGG" id="fai:FAD_0913"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="156"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="338" mass="38829" checksum="50002F68F113589C" modified="2017-06-07" version="1">MEYKGDKININDIIEKYSKDISTCELIYDLDFQYYFENIKYGGELSLLMSNKTGKKLGVCLQDLDDVNMHFVPEIYSGYKFARIAPKLSGLVAGIALYDYTNRKLTMLKLTGARNLGFITMVNHSYTTNMKINFKNIYLLEPSNALDTGIKNFRGKEKENKIIFFARLVYRKGIFDFILIVKEIVKSLRVEVVVAGQFQHSYEERYFFALLSKYHLEKFVKYKGKLTDDELYSELSTAKAMVYPSHSDSFSISILQAIYLNTPVVAYDIAGISVYKKFNCVKLVKEFDTTAMAKATIDILNGKEIEFSDPALGSFIEEHNSWDRVASAHMEIIDKYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Z8</accession>
    <name>A0A1V0N3Z8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142312.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Z8"/>
    <dbReference type="STRING" id="74969.FAD_0999"/>
    <dbReference type="GeneID" id="31676498"/>
    <dbReference type="KEGG" id="fai:FAD_0999"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="118" mass="13553" checksum="8C5828BE02C18304" modified="2017-06-07" version="1">MIEDLYKKWEHNKLSDSDFQDDLSGFGDFITKLYDDLKIDLIADLTPYKAYFNILKVNGFVNSILDKRPDLISTISSWFEREKGDIERIAKKIGVLYFSISMSIPGGIGISMTFQPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N401</accession>
    <name>A0A1V0N401_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142196.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N401"/>
    <dbReference type="STRING" id="74969.FAD_0931"/>
    <dbReference type="GeneID" id="31676436"/>
    <dbReference type="KEGG" id="fai:FAD_0931"/>
    <dbReference type="OrthoDB" id="57441at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF15">
        <property type="entry name" value="SLL1173 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="118"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="298" mass="34585" checksum="D863D3946A062633" modified="2017-06-07" version="1">MNFYIESFKRYRKNYVNYFSVMYNLRKNKSIIKVKLRDGQIHNWSNWKVKMYNAITLKAHSNVNIDVNSNDDLIAGTIKFTYKKRPLVFSVDEWTDIIEVFIEEGYKFLDVENENVIDIGTNIGDSTIYFAVSNAKRVLGLEPYPHSYSIALKNLEQNDIGKEKVILLNAGYGEDGLIKVKMDVTNTHGTNLKSSNEGTEIRTISLKTLLKEYDYESPVLKMDCEGCEYNLLKEDNDTLKKFKRMQIEYHYGYEKLKEKLENCGFDVTFTKPVQIYNKDASNPNMVIGQIYAKLPNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N418</accession>
    <name>A0A1V0N418_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142262.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N418"/>
    <dbReference type="STRING" id="74969.FAD_0969"/>
    <dbReference type="GeneID" id="31676468"/>
    <dbReference type="KEGG" id="fai:FAD_0969"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="69" mass="8305" checksum="F3535A161733D2D3" modified="2017-06-07" version="1">MGNRDRLQDDKKNPCKTTSRILNVRLLYFYLAILLYNVWIIMNIISRIIIIEDNLRIFMVSILIKIKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N464</accession>
    <name>A0A1V0N464_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N464"/>
    <dbReference type="STRING" id="74969.FAD_0998"/>
    <dbReference type="KEGG" id="fai:FAD_0998"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010397">
        <property type="entry name" value="DUF996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06195">
        <property type="entry name" value="DUF996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="224" mass="24598" checksum="22DCA6828DE84AD5" modified="2017-06-07" version="1">MGNFRTIIYNNHYHTINTNTQKIQELESARTYGIMGIILEFIGGPADIIFHGLGLIISIIGLILLFLAVKSISNNYSNQTPFKYMLYSLISGIILAVVAGISLFLLLIPIFNSASSTGSTSTFYMSLISIFLLIVVLVLVPSFVSIIFQYMAYDSVGKLTGIHEFHTAALLLLIGIILAIIVIGVILMFIGIIFLIIAFAKLPGEAKPALNDQTFNQDTNKEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N467</accession>
    <name>A0A1V0N467_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acylaminoacyl-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142413.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N467"/>
    <dbReference type="STRING" id="74969.FAD_1051"/>
    <dbReference type="GeneID" id="31676550"/>
    <dbReference type="KEGG" id="fai:FAD_1051"/>
    <dbReference type="OrthoDB" id="25019at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF27">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE FAMILY MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="389"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="587" mass="66696" checksum="4903F569C97D4E8C" modified="2017-06-07" version="1">MEGHRIEDLLRLKNIENVIIDSTGKRIAALAGSTYRDYKKKEFNKYIYILKEDLSTERVIQGTGIKCIDISDTGRLLYADGHGIHITGNGFSDLNIKFDGGIQQAKWMGDKILFTATVKKHSSPEDAYFFEENDPLNEMYLLDLSHGIKKITGNIHIWEFDNDGENIYAVTSSKPMESCWYNSSVSKIYLDGKVEKVYDPDFRELGKITVNGNRAAFLESIMSDRGVISGDIILLENGHAKNITMGSETTYSHIEFHKNSMYALENHMGTFTIRNMESGKAIWKGSGIVYPVFSPAFSTNGNIFVFPYSNEKEIAEIVRVESGKVSRSGINSELQNLKAYPSELVEWKSSDGKDIYGFFRSEGSEKPVIVYIHGGPTSFSYPAFIDRTTMYLGAGFSVFLPNYRGSIGMGRQYAESNRGDMGGMDFEDVITGINYLKKQGKIKTDRIYITGGSYGGYISALAIMKSDIFKASVSLYGISDWISFHGVSNLYNWDRVHMNDDPYNFRKYDGFSAIRMDHDVKTPVLLMHGVEDPYVPIGQYYEFYRFLKEHGKSVRLLVYPREGHGFTEKDHMITQYKETIDFFNRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N473</accession>
    <name>A0A1V0N473_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142381.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N473"/>
    <dbReference type="STRING" id="74969.FAD_1030"/>
    <dbReference type="GeneID" id="31676529"/>
    <dbReference type="KEGG" id="fai:FAD_1030"/>
    <dbReference type="OrthoDB" id="35948at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10789">
        <property type="entry name" value="GH38N_AMII_ER_cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="5">
        <location>
            <begin position="513"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD84911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1015" mass="118036" checksum="FF0345E1493769D3" modified="2017-06-07" version="1">MFKTNNKLIISRRLYEIISLSIIDVQIIDHVKLNNNDIKLPYSTFQNPDDINNFSFEVNLDKLEDNYKYLLSVEISGNAELIIDGILDQSIDAGHTYSIFNGPKREFILRTGSRELFGRNQWDLSIKSIKIITINYTLFQIGMELLQLYNYANTMGRSKNKIYNSMLKYLSTVYESPNIEQITGLAAVLLNKKHKELIDFLSDIYGYPVLNKTITDYNRNKINMDRYNNILDEIAKTINEISDSKYKNNTMFTFGHCHIDVAWLWPYSETVRKIQRSFSNVLKLYDMDFNFAFAQSTALYYYEIEKNNKSIFNKIKKLVKEDKWIPVGGMWVESDTNLIRGESLARQLLYGQSYFMEAFNRYARIAWLPDTFGFSGQLPQLFVKSGMNAFVTHKPMWNDTTEFPYHCFKWSGIDNTSIMTSISSLGYNENLDFDSIINACKLNKNSDLPITYLYGYGDGGGGPDIEMMLKLNQAKHSEFMPRVKSSFNEQDYISNLDKFNDKMPTYNGEIYLENHRGVYTTNHEIKKFVATLEDKLSMLEFLNSMNYGSATQRNNTKNLWYNLLKAQFHDILPGSAYYYAYEEEFTELDNLNEEIDKITIIAIKIFIENKNIKKGLIAINNSQYSFTGYLEIDSSNLPSEMPGNGVIHTMDKDFVLINVPALGFATVDQSAEDNKFQNPVKIRNVKGKYIVQNAKLKLIINSKGIISFFHNNKKYIKNGNIIRIYNDVPSNFDAWNIDVQNIKNDMHMEEIKTDIRIISENTIGVIEIKRTFEDSSFIIQKIIVKPDSDIVEFENTAILNNREKLVKVLFEPGFTTDYIRREIPFGYVRMKLDSANEKTHFEFPALRYVDYSDNDHGFSIVSRESHGYSFISNKLGISIGKTPLYPNPFSDRNGIKEKFYVCLHDRNYNIYKEANFIFNPVKLYNNKYDGNKKKERLLNFSGDDIILENIKISENEQGLIARFYNCSDKISNFELKIPDKDIYETDILENNKIKIDKNIIFKPFEIKTLLIEKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N496</accession>
    <name>A0A1V0N496_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type sugar transporter, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142377.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N496"/>
    <dbReference type="STRING" id="74969.FAD_1028"/>
    <dbReference type="GeneID" id="31676527"/>
    <dbReference type="KEGG" id="fai:FAD_1028"/>
    <dbReference type="OrthoDB" id="45815at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43005">
        <property type="entry name" value="BLR7065 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43005:SF1">
        <property type="entry name" value="SPERMIDINE_PUTRESCINE TRANSPORT SYSTEM PERMEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160964">
        <property type="entry name" value="MalF N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="76"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD84909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="296" mass="33323" checksum="FEBCBEA1DD01483C" modified="2017-06-07" version="1">MQQFAKNKFNFKKNAIFLILVPSFVYLLIFFIYPIFLSIKYSFTNLSLYDISHYAFTEFTNYKELFTSHLFLKSIYITIIFLIFSAIIGQMFLGSIIAYLITLTQKYFKIVVTTVILIAWATPQVTAGIMWYSTLSYIPDGTINFILTGFGLHSINFLSIHNALYSIIIANIWIGLGFSVLIFLGGIQGIDPSIIKASYVDGAKPFRRFFSIIFPLLKKSIITDLLLITLFTFGTFTLIYVLTAGGPAGSTELLTIYQYNTAFSLFSLGLANAIGVIIIIIALGLSLIYLKFIKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4C9</accession>
    <name>A0A1V0N4C9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1112</name>
        <name evidence="2" type="ORF">HLB00_00400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000011">
        <property type="protein sequence ID" value="NOL59299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886217.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4C9"/>
    <dbReference type="STRING" id="74969.FAD_1112"/>
    <dbReference type="GeneID" id="16024342"/>
    <dbReference type="KEGG" id="fai:FAD_1112"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="65" mass="7513" checksum="A7BE739807B51FC8" modified="2017-06-07" version="1">MPYIDYSRKSDSIEDIIKNECPVYSGDIIRRRLALSIYSTDSGKSMENSINSLMESYYENTYTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4D2</accession>
    <name>A0A1V0N4D2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886222.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4D2"/>
    <dbReference type="STRING" id="74969.FAD_1117"/>
    <dbReference type="GeneID" id="16024347"/>
    <dbReference type="KEGG" id="fai:FAD_1117"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26702" checksum="1DABA3AFC7259312" modified="2017-06-07" version="1">MENIVPFKTENTYMATEFMMKDPYKNTRLVSLLEDYPDYSKIIYDNGVIKGILSVDPVHDEMWFYGNSKSLKAVIGNIEIKSNQVLYIDKKNLDIIQSRFSVEYSGLLAMRLKIREYEGTTVADGVERDTGSTGKEDRHNNIFIKRKNGEILGSVKVLSLNIKSCAIGCLHYKDGYEGSIYDIISSIANIYKSQTENIVIYAPYQEKLKDGLLKLGFINSGELLKLYNIAPHQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4G4</accession>
    <name>A0A1V0N4G4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyl phosphate synthase small chain</fullName>
            <ecNumber evidence="9">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Carbamoyl phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">carA</name>
        <name evidence="11" type="ORF">FAD_1154</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. Tetramer of heterodimers (alpha,beta)4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143165.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4G4"/>
    <dbReference type="STRING" id="74969.FAD_1154"/>
    <dbReference type="GeneID" id="31676652"/>
    <dbReference type="KEGG" id="fai:FAD_1154"/>
    <dbReference type="OrthoDB" id="7675at2157"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="350" mass="39142" checksum="0C681C7B3A304E90" modified="2017-06-07" version="1">MKRYLLLEDGTTYEGTGYGYEGETNGEIVFTTSMSGYLETITDPSYAGEILIFAFPEIANYPLNLEHMESSKVQVAGIITKDAHAIFSGGESGTGFNEFLKQNMVPAIDGIDTRSLVEKIRESGAIKGYIRNKNEFPDKFEDTMDLDLVSRVSIKKYKYYNSGHKKEILFIDVGTKNSLIKRLSETASLHIVPYNYDFFNIKFHYDAIFIPNGPGNPDHSSLEPLRAFIREKSSSMPVMGVCLGNQLIALSMGGKTEKMKYGHRGINHAVLIGNRVYITSHNHGYAVNGDSLKGTCMEICGTDINDGTVEMIKHRELPVFSVQFHPEAYPGPYDSTWFFNDIKTTLGEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4H4</accession>
    <name>A0A1V0N4H4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HdrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142509.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4H4"/>
    <dbReference type="STRING" id="74969.FAD_1131"/>
    <dbReference type="GeneID" id="31676628"/>
    <dbReference type="KEGG" id="fai:FAD_1131"/>
    <dbReference type="OrthoDB" id="42878at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051460">
        <property type="entry name" value="HdrC_iron-sulfur_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43255:SF2">
        <property type="entry name" value="HETERODISULFIDE REDUCTASE RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43255">
        <property type="entry name" value="IRON-SULFUR-BINDING OXIDOREDUCTASE FADF-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="401" mass="45377" checksum="D8EDA74404EC2311" modified="2017-06-07" version="1">MNLIKQIEEITDKCISCGFCESVCPTLEPDGYNSVFGARGRVILADFALKENSEGVELGNSFYSCLDCYACVNVCPAGVNAGVVSELMRELVASGNKGKKNPVAEMIKSSIMEYGNPLGLKEESAKWAEGIKFDDSSTMLITGQMYQMMPYTRKINKVRKYIDENFTMNIASAMIKHISLIKFSRHFYDKQLRDKMNGDLKNIVSMLQKSGVKFNYLGAEEPYPGMFLHELGYAKEFKEYAETVYNLLKEKGVKRIIAIDPHTYDIFKNVYPEVVKGFKIPVVYYTDLLDLEYRKFNGNITVQEPCHIVLHNNNFKAIDILNSVAEIKLPERSGKSTMCCGGPDELLFPDTAKKVSMKRYKDLKAKSDNVITICPLCYNNLAYDENVMDFSEFMGSLMVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4H9</accession>
    <name>A0A1V0N4H9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">thymine-DNA glycosylase</fullName>
            <ecNumber evidence="14">3.2.2.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FAD_1157</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.</text>
            <dbReference type="EC" id="3.2.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.29" evidence="14"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074116.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4H9"/>
    <dbReference type="STRING" id="74969.FAD_1157"/>
    <dbReference type="GeneID" id="31676655"/>
    <dbReference type="KEGG" id="fai:FAD_1157"/>
    <dbReference type="OrthoDB" id="84708at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141016">
        <property type="term" value="F:G/T mismatch-specific thymine-DNA glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001435">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="27"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD85033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="209" mass="23396" checksum="6753F87FAE68E9C3" modified="2017-06-07" version="1">MKIREVSPEHHFEFTDSPFWILITTILSHRTKDIVTDQAARSLYNKYHDSVGLENADPADVKAIIKYVGFSNVKSLRIIEIARIINHEYGGKVPDTHDELVKLPGTGSKTANIVLTQGFNIPAIAVDTHVFRVSNRIGLVHTKNPDETEEALKSIVPLEYQVEFNPVMVEFGKNICKPVSPRCNICPVSDCCDYFAQKNTGDTAIKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4J2</accession>
    <name>A0A1V0N4J2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ORF">FAD_1148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4J2"/>
    <dbReference type="STRING" id="74969.FAD_1148"/>
    <dbReference type="KEGG" id="fai:FAD_1148"/>
    <dbReference type="OrthoDB" id="9473at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23046:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23046">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurE" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="155" mass="16593" checksum="B616EB07C8BA5F94" modified="2017-06-07" version="1">MKVAVIMGSRSDFPVMQDAVNELKNFGIEVEYRIVSAHRTPEFMLEYASNAINNHIEVIIAGAGGAAHLPGMVASMTTLPVIGVPVQSKALNGIDSLLSIVQMPPGVPVATVSINGARNAALLAVRILSIKYPKIKEMLQAFIDNQRDTVLGDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4J7</accession>
    <name>A0A1V0N4J7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Carbamoyl phosphate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FAD_1155</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142543.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4J7"/>
    <dbReference type="STRING" id="74969.FAD_1155"/>
    <dbReference type="GeneID" id="31676653"/>
    <dbReference type="KEGG" id="fai:FAD_1155"/>
    <dbReference type="OrthoDB" id="85487at2157"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000026">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="131"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="664"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="18">
        <location>
            <begin position="916"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ARD85031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="1051" mass="116849" checksum="CC61EAD3B3FEAAB8" modified="2017-06-07" version="1">MNSDIKCTLVIGSGPIVIGQAAEFDYSGSQACLALKEEGIKTVLLNSNPATIQTDREIADRVYIEPVDPESVIEIIKKEKIDSILPSTGGQVGLNLVILLERLGILSSYNIKVLGTPVTSIEIAEDRKKFFNLMKKIGEPVIESYTLTKNDYRDLMPGIKKYPLILRTGFSLGGSGGVIIKNVKELSDYCDDYFSVHDDMVELDESLLGLKEIEYEMMRDNNGNCISICNMENLDPMGVHTGESIVTTPSLTLSNDSYQKLRTSAIHVVNEIGVIGSCNIQFALDQEKDEYYIVEVNPRTSRSSALASKASGYPIARVSTKIAVGYNLNEIKNPVTKNTYAAFEPSMDYITVKIPRWPFDKFSVKREIGIEMKSIGEAMGIGRIFEEALMKAISSLDIKQSIPMRLFTSPEKTIELMKVPNDLRLFAIFDGLFQGIGVDKISELSGYDKFFIVKIKNIVDAMETIKRGVIPENMENLKMLGISDETISYYTGIPQTEIIKYRIEKKIVPVYKNIDTCSGEFNADTTYLYSAYDTHNDNRISNKKKVIVIGSGPNRISQGVEFDYGAVKSILSLRSMGYEAIMVNSNPETVSTDFDISDKLYFEPVTLEHISNIASAEKPEGIIIQFSGQTGQNMASGISEIFNNIILGTKPEDIYRIEERTIFSKTLRSLGIKQPDFIEASNINELEEKIKGISLPVIIRSSFIIGGRAMDIIYDYDILVSRVRELFIERPGSPVLVSSYLKNATEIDVDFISSAEKSIIAGISVHIEEAGTHSGDATMVLGPGVVDSDTLEQLKEIVEKMRQNFNLSGLSNLQLAIKGSEIYVIELNARSSRSVPFVSKATGINWIDSGVKAMLGIEPELKYSEPASFFIKVPVFPFKRFRDMDVILGPEMKSTGEAMCCGKTFQEAMSKVIRIMKRDFKLNSVIITVNDADKNEAIKIGRKLAAKNVKIYATPGTYNAMKDAGVKSNVVYRVKDLRSPGISEIIKNEDISMIINTPSESYGSIRDGFSIRNLGIKKDIPLITNIRFASELVDSILHEKKAQVMELTEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4K2</accession>
    <name>A0A1V0N4K2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-ethylammeline chlorohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142573.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4K2"/>
    <dbReference type="STRING" id="74969.FAD_1194"/>
    <dbReference type="GeneID" id="84217789"/>
    <dbReference type="KEGG" id="fai:FAD_1194"/>
    <dbReference type="OrthoDB" id="42910at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01305">
        <property type="entry name" value="archeal_chlorohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF5">
        <property type="entry name" value="CHLOROHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="332" mass="38419" checksum="A0D275027B654202" modified="2017-06-07" version="1">MEFSGNIYYNGKLRRGTLKVDDTGESFSNKTGNTNHGTLIPMPVNAHTHVGDSFINEEPKGTLPEIVGPDGLKHRFLDNADDNEVINYISKTNNFMEKNGTISYFDFRENGLKGINMIKRGNKKFIKPVIFARPYNNDDINKIIDNSNGVGISSISDMDYDDIYDVSIKTHKKNKIFALHFSENINEDIDKVMNLKPDLLIHGIEANDTDLDIIGKNNVSIVITPRSNIFYGKRPDYNKFLKHNINLMLGTDNVFVTEPDIFSEMDFLYRYQRFLNYVSPENILKMVIDNPYTFLKKNNIKIKKRYLFFKNELLNEYQLVTKKHYFNPVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4N5</accession>
    <name>A0A1V0N4N5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8 9">Riboflavin synthase</fullName>
            <ecNumber evidence="4 8 9">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FAD_1197</name>
        <name evidence="12" type="ORF">HLB00_09820</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin</text>
            <dbReference type="Rhea" id="RHEA:20772"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="EC" id="2.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000437">
        <property type="protein sequence ID" value="NOL61114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142579.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4N5"/>
    <dbReference type="STRING" id="74969.FAD_1197"/>
    <dbReference type="GeneID" id="84217792"/>
    <dbReference type="KEGG" id="fai:FAD_1197"/>
    <dbReference type="OrthoDB" id="23911at2157"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09210">
        <property type="entry name" value="Riboflavin_synthase_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006399">
        <property type="entry name" value="Ribfl_synth_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01506">
        <property type="entry name" value="ribC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015750">
        <property type="entry name" value="Ribfl_synth_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR01506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL61114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="162" mass="18020" checksum="FD6324E81FE73BE8" modified="2017-06-07" version="1">MKLIGIVDTTFARYDMASSAIDELYKTGTGFDIKRYTVPGIKDTPVAALKLFSEYNCDLVMAFGMPGPMPVDKMSAQIASTGLMEVQLKTMKHILEVFVHEDEAIDDRELAWLCDNRSREHAVNAYYLLFDPEKLTENAGNGLRQGFEDRGPVNSGSAGHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4U2</accession>
    <name>A0A1V0N4U2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thermopsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142768.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4U2"/>
    <dbReference type="GeneID" id="31676790"/>
    <dbReference type="KEGG" id="fai:FAD_1292"/>
    <dbReference type="OrthoDB" id="57559at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007981">
        <property type="entry name" value="Peptidase_A5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05317">
        <property type="entry name" value="Thermopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="514" mass="56118" checksum="47B9ECF2741CB8F1" modified="2017-06-07" version="1">MNKFAIVFISIIMVLSVYGGIYMNNGTNAHLNNPGVSPATVNPEYHYSKEPAPMGIADYGIGPGGTSSSFNSTAFTGIVNITDLKTYNASISICPDNMGIQLNLIYSFQNGNSTYYYWVQNVAVLNTSNRQVVFVDNVWNFTSTNAEMHNSTMHGNGTLMNSSSAHLYYFASDNGTFRSFSYSNIKLRSVSYTASGYPHIYMEYNDGNGWKTYDTLNFTFASSVSHNYGFIVNGQNLLPNNLYADAGLILGGPGNSTNTRVIQANLTMGLEYWNGHNYQAVSNAYNHGSDTAEGVCNVSVSYNSASMIPMAHIETGNTTPGELYNSSNVAVFNFKSTVKNTYIKLNGSRYNFTGQYLNLTLNPGTYNFTLFSKYGQPVYSRNYTLSAGGYYSYTSGPSYNVTFTEKGLAAGTEWGVQVNGNALYSTGNNITFVLYNGTYNYTIPSVAGYSITGGSGNFTVNGADNSINITFVQNPSPVTLYNYIQDYKIIITIVIIGIVALIAIAAIRSEHNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4U3</accession>
    <name>A0A1V0N4U3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4U3"/>
    <dbReference type="STRING" id="74969.FAD_1238"/>
    <dbReference type="KEGG" id="fai:FAD_1238"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="242" mass="26708" checksum="C26D9C3E34CB13E0" modified="2017-06-07" version="1">MVANGIHMSGKNILIAGTGELGKSLSYDLLLQNNRVIINSRDAGKLKEIVSEFSIYGKIDYIAMELKDEGSCKNLVVKAAESIKHIDSLIVMVGGFIEDSIENLDGLESMITNHLKIPLYLSKYALEHMVYGSSIIFVSNSSISIKNKTNLLSYSISKYALEKSAKIMAAELLEKGIRVNVVAPEYIKQNFEIGRNYSKMRKYGDLETPPEDISDLIDFLVEGKSSWINGAIIPVDGGHSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4W3</accession>
    <name>A0A1V0N4W3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VIT family Fe2+/Mn2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1261</name>
        <name evidence="3" type="ORF">HLB00_02960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000096">
        <property type="protein sequence ID" value="NOL59795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886364.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4W3"/>
    <dbReference type="STRING" id="74969.FAD_1261"/>
    <dbReference type="GeneID" id="16024489"/>
    <dbReference type="KEGG" id="fai:FAD_1261"/>
    <dbReference type="OrthoDB" id="57551at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="174" mass="18753" checksum="559BEFB96CFCDA91" modified="2017-06-07" version="1">MNKKYIFPVSIGLSDGIITALILASGGIIGKSSIDLFQAFRISFGSSFAGAFSYFIAQYAGLNEELHRTALQLNLKSTDYLLKGHLGIEIFVESLLGALIAAFFGFLGALIPLSSSLIVRNNIEIPLFLSYLSLAVLGLFISKTTAGRAKFWIVVMVIVGIIVTIAGYELKLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4W5</accession>
    <name>A0A1V0N4W5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142755.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4W5"/>
    <dbReference type="STRING" id="74969.FAD_1283"/>
    <dbReference type="GeneID" id="84217878"/>
    <dbReference type="KEGG" id="fai:FAD_1283"/>
    <dbReference type="OrthoDB" id="52531at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="entry name" value="Cobalamin biosynthesis CobH/CbiC, precorrin-8X methylmutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43588">
        <property type="entry name" value="COBALT-PRECORRIN-8 METHYLMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43588:SF1">
        <property type="entry name" value="COBALT-PRECORRIN-8 METHYLMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="Precorrin-8X methylmutase CbiC/CobH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC" evidence="5">
        <location>
            <begin position="9"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="199" mass="21625" checksum="49E8DD7FB63059C6" modified="2017-06-07" version="1">MSSTLSPAEIYRRSFTFIKEKMGLDNSLKSSIITRVVHATADFEIGKSMVFSSSFEDSLSAIENGTMVIADINMVMSGISRYNNKKCYIGDKDIAMEAKRTGISRSYLSMSRACRDNPEAVYVIGDAPTALEALIDSIDAGICFPRLVIGVPVGFVSALEMKSRLLAFQGNFITNLSNKGGSAVAASIFNAMVVYLHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N511</accession>
    <name>A0A1V0N511_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N511"/>
    <dbReference type="KEGG" id="fai:FAD_1322"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="232" mass="24461" checksum="C7AEFF6B55D20954" modified="2017-06-07" version="1">MAAIFVMLAFIPAADNMHTAQSSIAIPQQGKAYQLNNQATPYLLLNHPNITINTVKLRDGFMISTFINGSLSSWVIYQNNIQAGRVNIIAFNDGNFSFYSHNVNENNTTGAVNTSNMTNHTEASIAATYSPGDAKFSVGWDGWAISFSHSELCEIVTALNAGNAVSSIIALITGFSGIGAAIAAIPTVASIIMGLGAIGLSDLAHKCGNGAWMGTNIFAHPEVGCNPVPYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N517</accession>
    <name>A0A1V0N517_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable urocanate hydratase</fullName>
            <shortName evidence="7">Urocanase</shortName>
            <ecNumber evidence="7">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hutU</name>
        <name evidence="11" type="ORF">FAD_1379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>4-imidazolone-5-propanoate = trans-urocanate + H2O</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="7">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142867.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N517"/>
    <dbReference type="STRING" id="74969.FAD_1379"/>
    <dbReference type="GeneID" id="31676871"/>
    <dbReference type="KEGG" id="fai:FAD_1379"/>
    <dbReference type="OrthoDB" id="173478at2157"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="entry name" value="Urocanase like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1770.10">
        <property type="entry name" value="Urocanase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055351">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003820">
        <property type="entry name" value="PRK05414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216:SF4">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase Rossmann-like" evidence="8">
        <location>
            <begin position="135"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase C-terminal" evidence="10">
        <location>
            <begin position="347"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="269"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="552" mass="60886" checksum="A212713DD96745C8" modified="2017-06-07" version="1">MEHTDIHAPHGNKLNTKGWSQEGAMRLLMNNLDPMVAKDPANLIVYGGKGKAARNWEAYDKIIESLKSLENDETLLVQSGKPVGIFRTTKEAPRVLIVNAQIVPHWATDDVFWDLEARGLTMFGQMTAGSWVYIGTQGVLQGTYETLYALAKKVYHSDNLKGKWFLSAGLGEMGGAQPLAAKMNGCTSIIVEVDKEKINRRLRDKYLDTYTETLDEALKLKDEAIKSGKPVSIAVLGNAATVYQELQDKGVVPDIVSDQTAAHDLNLGYVPEGYTIANFQKFREENPEQFKKKVYETIVKQVKSMLYFQSKGSSVFDYGNDIRTRAKEGGLSNAFEIQGYVPAYIRDLFAVGSGPFRWLALSGNPDDIKKIDDAILKNIDDKHLTDWIKLAKEYVHFQGLPARICYASYGEREKIGLMINDMVRKGELEAPVAIGRDHHDTGSVASPYRETEAMKDGSDAIADWPILNALLNAISGASWVSVHHGGGTGIGNAIHSGFVIIADGTDDAAERIKRVLNADPGIGVIRHADAGYESSRDIIKKGPKFKSPYFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N542</accession>
    <name>A0A1V0N542_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142870.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N542"/>
    <dbReference type="STRING" id="74969.FAD_1382"/>
    <dbReference type="GeneID" id="31676874"/>
    <dbReference type="KEGG" id="fai:FAD_1382"/>
    <dbReference type="OrthoDB" id="25755at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16243" checksum="1CEA77F2C0B7EC0E" modified="2017-06-07" version="1">MEFSGKITIKNNKGNVAEFLSDIDNITPCLPGVYDFQNNGGEIQCKLKLDISAAKISAMSSVTGKMSFLYKVGLDSINIDGSGRIAGSKVKFNISISYESHGEETVLDWKSSFDFGLIVKMMGKDRVNEISRENIDRTMGCITSKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N560</accession>
    <name>A0A1V0N560_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142862.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N560"/>
    <dbReference type="STRING" id="74969.FAD_1373"/>
    <dbReference type="GeneID" id="31676865"/>
    <dbReference type="KEGG" id="fai:FAD_1373"/>
    <dbReference type="OrthoDB" id="15372at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197:SF1">
        <property type="entry name" value="UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="240" mass="26882" checksum="199B47A86C98E88D" modified="2017-06-07" version="1">MDALITAAGLGTRANLPEGMRKEMLPVYAVRNGKIVLRPILECIIHNLSLSGADKFFIVLDAKDRHTADYLSTLNVKSEYIYQKRAEGYGKAVALAKEYILGDFILNAGDGLILDRNKTKNMVDLYRSTGKTILSVMAVPNPQRYGVANIKNGIVESVVEKPEHPTSKYALAAFYVIKRDVMDLLDGTELTPAINRHIINGNTVIPFKIRRSDWLSIGNSNDYYKILRRAYNFSRKLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5F7</accession>
    <name>A0A1V0N5F7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1940 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1528</name>
        <name evidence="2" type="ORF">HLB00_02615</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000082">
        <property type="protein sequence ID" value="NOL59726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886665.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5F7"/>
    <dbReference type="GeneID" id="16024794"/>
    <dbReference type="KEGG" id="fai:FAD_1528"/>
    <dbReference type="OrthoDB" id="56433at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015238">
        <property type="entry name" value="DUF1940"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09155">
        <property type="entry name" value="DUF1940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="155" mass="18176" checksum="8316D3EC834DB3D1" modified="2017-06-07" version="1">MEDEQSGEYCELIDRNLPPDHDFFLYESHVKIVKSFLGLAVSEARNVEKLRTMLDILDTLNQNLYDNETVLADNVRKQLRRETKEWIDIDQKMDNGDKYTAYLVLAASNLRIALSYLWRLSKLPDFSDHITEYPLEFMQKLINMINNEAMGNVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5F9</accession>
    <name>A0A1V0N5F9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1483</name>
        <name evidence="3" type="ORF">HLB00_03065</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000098">
        <property type="protein sequence ID" value="NOL59815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886589.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5F9"/>
    <dbReference type="STRING" id="74969.FAD_1483"/>
    <dbReference type="GeneID" id="16024714"/>
    <dbReference type="GeneID" id="31676976"/>
    <dbReference type="KEGG" id="fai:FAD_1483"/>
    <dbReference type="OrthoDB" id="56972at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="210" mass="23854" checksum="C68E98300C52F50F" modified="2017-06-07" version="1">MEEYPTPVKIILLLKEFPGLTLDELAEKMSISKMAVLNHISALEQQGAVARKIVKKKVGRPSFIFYALPVSNNKLGNSSDSMLNDFMDFIKTTGNEKLLEEFLKDRYSKVRSEYTGAMRGKNLDEKVNELAILRRNADYYPEVKRAQGNFELIEYNCPILSISKNFGIACSMETKMFSQVLDANVKSTHRQVNGYSACRFLISSKSKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5G7</accession>
    <name>A0A1V0N5G7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoserine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FAD_1533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886669.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5G7"/>
    <dbReference type="STRING" id="74969.FAD_1533"/>
    <dbReference type="GeneID" id="16024799"/>
    <dbReference type="GeneID" id="31677024"/>
    <dbReference type="KEGG" id="fai:FAD_1533"/>
    <dbReference type="OrthoDB" id="10041at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0718">Serine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="229" mass="26010" checksum="3DF467995B9FF7B7" modified="2017-06-07" version="1">MIEIVDRKKKTNINPEADYLENIKLMVFDMDGVLLKNRNSWDVIINRSMNKTTTGTGMQLTFDYIYQNGVPDRLYENLTETKIMTYLNLNDVTSNIARTIGYLKDRNIKTAIVSAGSHVFAGYLSELFGIDNFIGNEVNVKNHCFIKNVDPAKKDTNVKDIQSRYGISPAETVSVGDSYMDLSMRRRSKYFVAFNPGTRKLVDAADFVVNSTNLYGIIEKMAVHEIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5J6</accession>
    <name>A0A1V0N5J6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142948.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5J6"/>
    <dbReference type="STRING" id="74969.FAD_1538"/>
    <dbReference type="GeneID" id="31677029"/>
    <dbReference type="KEGG" id="fai:FAD_1538"/>
    <dbReference type="OrthoDB" id="307696at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000004">
        <property type="entry name" value="Electron transfer flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF11">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN, SUBUNIT ALPHA (ETFA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Electron transfer flavoprotein alpha subunit C-terminal" evidence="4">
        <location>
            <begin position="171"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="293" mass="32908" checksum="D65AAA7808B33AB6" modified="2017-06-07" version="1">MKALVFSNEPKNAMEIITYLRGKMDIDVISQENKELPEYGANTVYFYSNGFVDNLGKFLADYIGKNNYDFIFISSTNMGRELAGILSFKLKMKCMPEIFSFEHKEKNITRRFYHGGKTVVEEESNFKMFTVSPGICEAEKADKKSEVKNLTLEKSDYKIVDVKSKKTAGTDIRNAKVIVSIGRGLGSQENIEKVMPLVDVLHAEISGSRPVCLDYKWLSEDKQVGLSGKKVRPEFYIALGISGQIQHIAGIRGSKTIIAINKDKSAPIFEECDYGLVGDLFTIVPQLVEKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5L4</accession>
    <name>A0A1V0N5L4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FAD_1559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886701.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5L4"/>
    <dbReference type="STRING" id="74969.FAD_1559"/>
    <dbReference type="GeneID" id="31677050"/>
    <dbReference type="KEGG" id="fai:FAD_1559"/>
    <dbReference type="OrthoDB" id="41618at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016682">
        <property type="term" value="F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365:SF14">
        <property type="entry name" value="CYTOCHROME BD MENAQUINOL OXIDASE SUBUNIT I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="CYTOCHROME D UBIQUINOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="488" mass="54295" checksum="583B15D7F9BCAA3C" modified="2017-06-07" version="1">MGISYPVWDSAMFAYTISAHIIIVAITLAMALMITITEYIALKHKNKYYEALTHKLSIALVINFAIGTASGVFMAVELMLFWPVFMKLVGAVAMLSFYAEVFAFLVESVTLMVYVYFWDNFKNRWNHWLVSWGILIGTGASAWLITNVNAWMNTPTGSFNIAKYMSSGETIITGVNPLKVFYEPSTGAELFHMFMAMYFAGSMALLAYFAYKYLKSKNENEKIIDKLAMKILSAIGIVDIILIGISGSIELSTLLTVEPLKYAMLELNLHPVMAGAPEHLFGFISNGKAVDFIPLAGIQSLLAYPLTKGNAGYIPGLSSYPTYTWAPSVIHSTLDLMVGFGLLMGLFWFIVLVLRIMKKDIFKMKSILYGFIALGFLGIFTMEDGWYTAEVGRVPYIILMPYNSAGQPIVAGHYGVMTIAQAASTSTIVWYLGIVIILFYLIIIPFTFYFNAKVLNLSNVEEELRKAERDLNLPETGKDVNSLNAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5M2</accession>
    <name>A0A1V0N5M2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="9">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ogt</name>
        <name evidence="12" type="ORF">FAD_1537</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="9"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142947.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5M2"/>
    <dbReference type="STRING" id="74969.FAD_1537"/>
    <dbReference type="GeneID" id="31677028"/>
    <dbReference type="KEGG" id="fai:FAD_1537"/>
    <dbReference type="OrthoDB" id="372118at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000214">
        <property type="entry name" value="Methylated-DNA--protein-cysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.70">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF5">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 9 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylguanine DNA methyltransferase ribonuclease-like" evidence="11">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="10">
        <location>
            <begin position="89"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ARD85386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="171" mass="18969" checksum="CE10E31555CCD64D" modified="2017-06-07" version="1">MKNNNIKIQYFKTKIGELILGSFEGNLCILDFRHSKKRTTIDNRIKTGLKANFLEEEDEILAETKKQVAEYLDGNRKEFYIPLLMVGTDFQKNVWNALLKIPYGTTISYLQLAENIGNAKAVRAVANADGANAMAVIIPCHRVIESNGGLGGYGGGVAIKKQLLELEKGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5P1</accession>
    <name>A0A1V0N5P1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142975.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5P1"/>
    <dbReference type="STRING" id="74969.FAD_1591"/>
    <dbReference type="GeneID" id="31677081"/>
    <dbReference type="KEGG" id="fai:FAD_1591"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="26"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="469" mass="53096" checksum="F4494DCBCAF8F614" modified="2017-06-07" version="1">MQNKPYEGSVSDRLERIPFSSVQRDFLLMVAGGEWAETLMLLGNGAILALVVSVLGITHSLGATIITTAFFLGEFVGSAFFGWLADRRGRKFVFLYNLLVFSFGMLIAGFMSDPFLIAVFIFIGGIGVGGEFPLVDSFTTEMMPAKVRGNRLAWVYTIAVTAGFVIAFLTYEMDIIAPTYYSWRILFWFMAVVGFAIWAVRTRLKESPRWLEVHGEYKKANEITTEWEQKTMERKHLKELPPVTTNTPIEQNRSKYKDIFEPDVRKRSIMMIIFQFFQSGIFYGFTALSPLFLIDKGFDLPKTLEFTFLIYAGFFFGSVFNLFIIDKVERKWGIIGTAVLAGIFGTAFAVVSNVYLIVIFGFITTFLLWNFSNFYHAYQAEIFPTRIRPTAAGTVYAVSRVSTAILTLFIVDIFLPHGVLASFGIIWVFIAIVVVDIWVLGPKSSKEQVETIAQLYCPVNISYIYPLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5R4</accession>
    <name>A0A1V0N5R4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5R4"/>
    <dbReference type="STRING" id="74969.FAD_1606"/>
    <dbReference type="KEGG" id="fai:FAD_1606"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="70" mass="8197" checksum="14905E3B66F21C46" modified="2017-06-07" version="1">MWNINSEMTRCHRAIGTITDIDMERSIPEFNTVLNALSAKLFQKEVMRINIALDRNIMPAIIKGFRRYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5T4</accession>
    <name>A0A1V0N5T4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1666</name>
        <name evidence="3" type="ORF">HLB00_00450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000012">
        <property type="protein sequence ID" value="NOL59309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_155951150.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5T4"/>
    <dbReference type="STRING" id="74969.FAD_1666"/>
    <dbReference type="GeneID" id="31677157"/>
    <dbReference type="KEGG" id="fai:FAD_1666"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="276" mass="30943" checksum="5544B37BA1BD7EAD" modified="2017-06-07" version="1">MKRRTIFMTVIAILIILTASIMIAVIDNVSSEVDVEKPSPATNGAYFVYSYTSELRCKSFPSNSIYKNETLKHGDLYINGRVYINITGSSAVFHSYLCNSTGTIIANRTFSEPLNGTIFTAMFPEENHINTGNIVIFGNNVIAIKGMYTTCPSSHYVVNYGKKQVQYIPYIGKIESLTDVIQDYNYSLFNYANFIQSRGYSILSSISIPGNSSIAAMIQDNIGIKTSWFTMKLDRTNVGITAINYISYIEKYTIVYAVIWIIGIGYLISIKVKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5W8</accession>
    <name>A0A1V0N5W8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143022.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5W8"/>
    <dbReference type="STRING" id="74969.FAD_1680"/>
    <dbReference type="GeneID" id="31677172"/>
    <dbReference type="KEGG" id="fai:FAD_1680"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="196" mass="22115" checksum="9D679E1133B5B5D4" modified="2017-06-07" version="1">MPDTIYVYENHKITGPDGYNVDIIISDHGKEITIEGTDNIQLKREKGKYIISHNFLEEGNLERGSAMEYRGTNFWIPKKDMKKLRMLNFAIYSQNIEVAYINKFKNSLNINIEKNEYTIPVIIYIAVLSRELKEKFGKLYMKTGALNMAGSVLYPLLGISSLLGVSVNSPAIYIVSILIFVALPVASSIIGRKGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5Z3</accession>
    <name>A0A1V0N5Z3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="6">SHMT</shortName>
            <shortName evidence="6">Serine methylase</shortName>
            <ecNumber evidence="6">2.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glyA</name>
        <name evidence="9" type="ORF">FAD_1713</name>
        <name evidence="10" type="ORF">HLB00_00110</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000005">
        <property type="protein sequence ID" value="NOL59242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143047.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5Z3"/>
    <dbReference type="STRING" id="74969.FAD_1713"/>
    <dbReference type="GeneID" id="84218333"/>
    <dbReference type="KEGG" id="fai:FAD_1713"/>
    <dbReference type="OrthoDB" id="5821at2157"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in substrate specificity" evidence="6">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6 7">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL59242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="433" mass="48056" checksum="6047539EAC8B48B2" modified="2017-06-07" version="1">MLNKSDEFLEDALFIRELAMKHNKFFEESIPLIASENIMSPMAMEMLLTDLGFRYAEGLPHKRYYQGNQIVDIIEDKVTDLGRALFNAKYVDPRPLSGTNSNMAVLYAFTKPGDTITTPALSGGGHISSAPFGAVGFRGLKTLNYPFDVDEMNIDVDGTIKLLKQAKPKLAWFGQSVFLFPTPLKELRDTLEEIGSTVVYDAAHVLGLIGGKQFQDPLREGAQIITGSTHKTLPGPQHGIIIGETTEEKWKKVQRGVFPGTLSNHHLNAMAALGVTLAEHLDYGEAYAKQIIKNAQTLGSELSKLGFNVLGEKNGFTKSHTLAIDVSKNGGGKEVAEKLESCNIILNKNLLPYDDNKKSMNPSGIRIGTQEVTRIGFKEADIKELAELISDIIIKKKDPEVMAEKVRDFKSTFNEVKYCFGKFKPYQYIELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N601</accession>
    <name>A0A1V0N601_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arylmalonate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143041.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N601"/>
    <dbReference type="STRING" id="74969.FAD_1707"/>
    <dbReference type="GeneID" id="84218327"/>
    <dbReference type="KEGG" id="fai:FAD_1707"/>
    <dbReference type="OrthoDB" id="41425at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="BLR3294 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267:SF1">
        <property type="entry name" value="BLR3294 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25514" checksum="0F36B131F3DB441F" modified="2017-06-07" version="1">MIRVGMIVPANNVALEYDMYRMAPENMSFHSTRMRPSRNCEPDDPVKFRNDLKQAYSLLRRSSNVIVYGRTFGTHKNADIIREVFGRNVIIPEEAVIEYLQESGSKYMWLGTPYIKERTDEEKEYFSKKGFHIAGSYGLNKIYALDIARTSLEEIRCMLDKNIGTVEKSDLIYISCTAMPTSKILDKLSSIYGKPVLSENSAILWKISRITGNPIRIPGLQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N616</accession>
    <name>A0A1V0N616_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_1734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886876.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N616"/>
    <dbReference type="STRING" id="74969.FAD_1734"/>
    <dbReference type="GeneID" id="16025009"/>
    <dbReference type="KEGG" id="fai:FAD_1734"/>
    <dbReference type="OrthoDB" id="40991at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="entry name" value="Phosphate transport system protein phou homolog 2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930:SF2">
        <property type="entry name" value="PHOU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109755">
        <property type="entry name" value="PhoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="1">
        <location>
            <begin position="139"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD85573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="322" mass="37254" checksum="FF59AF63D70B16A8" modified="2017-06-07" version="1">MQSIRKIQLTGGSTYIVSLPSKWVKNNNLQRSSEIKIEESQNRLILYGDVGVKTEIEKHLILNSKMDSKSIERALISLYISGYDTLAITSSYYISDETREAIKKFSKLVIGIEIFEENSKKIVLQNVLNSNSYPIYNSIKRMSLNVESMIYDTIKGINDMDNDLLKNVIERDDEIDRFQWYIYREVKGKSCEDPNSIYYLIISRILERMADHTVNICKIWLERNDTDIPYKKVVENLSFSLDLYKKSMALFYSKKYNGLNDIISFKKTIMDQKKELLDLGKSSDIATISFSSEEISRIALYSTDIAELAMDMVLSMQNETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N642</accession>
    <name>A0A1V0N642_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Box A-binding protein</fullName>
            <shortName evidence="7">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">TATA sequence-binding protein</fullName>
            <shortName evidence="7">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tbp</name>
        <name evidence="9" type="ORF">FAD_1781</name>
        <name evidence="10" type="ORF">HLB00_08040</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000298">
        <property type="protein sequence ID" value="NOL60776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886929.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N642"/>
    <dbReference type="STRING" id="74969.FAD_1781"/>
    <dbReference type="GeneID" id="16025060"/>
    <dbReference type="KEGG" id="fai:FAD_1781"/>
    <dbReference type="OrthoDB" id="350539at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04518">
        <property type="entry name" value="TBP_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000007">
        <property type="entry name" value="TATA-box-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000010">
        <property type="entry name" value="TATA-box-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033711">
        <property type="entry name" value="TBP_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001593">
        <property type="entry name" value="PRK00394.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001597">
        <property type="entry name" value="PRK00394.2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001598">
        <property type="entry name" value="PRK00394.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ARD85620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="NOL60776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="184" mass="20493" checksum="92AD02FEEC2E51B6" modified="2017-06-07" version="1">MSEMEKITIENIVASTSLAEHLDLSRIALALEGSEYEPEQFPGLIYRLKDPKTAVLIFRSGKVNCTGAKNLENVKKTIDIIIDKLKKAKIEVYDNPDIIVQNIVAVYDLESDLNLTDIAMSLGLENVEYEPEQFPGLVYRVEEPKVVLLLFGSGKVVCTGAKEESEIEQAVIKVKKELQKVGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N659</accession>
    <name>A0A1V0N659_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1726</name>
        <name evidence="9" type="ORF">HLB00_00185</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000007">
        <property type="protein sequence ID" value="NOL59257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143059.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N659"/>
    <dbReference type="STRING" id="74969.FAD_1726"/>
    <dbReference type="GeneID" id="84218347"/>
    <dbReference type="KEGG" id="fai:FAD_1726"/>
    <dbReference type="OrthoDB" id="18103at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051538">
        <property type="entry name" value="Acyl-CoA_Synth/Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43334">
        <property type="entry name" value="ACETATE--COA LIGASE [ADP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43334:SF2">
        <property type="entry name" value="ACETATE--COA LIGASE [ADP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13549">
        <property type="entry name" value="ATP-grasp_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="468"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="657" mass="70816" checksum="24910372CF3283A7" modified="2017-06-07" version="1">MLEQLFKPKSIAVVGASSDSLKVGNIILRNITSSFSGKVYPVNNKTASIDGLTAYKSLIDIKESVDLVVIVVPRDAVPGVMKDAATIKAGAAIIITAGFKETDQHGAELEDQIMAIARESGIRVLGPNTIGLITPDVNATFAFADVKKGKAALVAQSGGLGVYMLNWAQESNVGISYFISLGNQADVDETDAFQFLSTDVETRAIFSYVEGVSSGQKFLTTLPDVIRRKPIIFLKGGMGKTGAAAVKTHTGSVAGSMDIFRAAVRTVGGIFVDNIEDMLNLAKIVLSSEPVSSDILIITNSGGHGVLTTDAIDKEGLNEIELPERVKHDLLSVMPEQSTPRNPIDLSGDANYDRYNKALGIIKDLDCTKIVIVQSLPMVSCSDVAKAMVNYRGKGVIGVTMGLDQNAASKLLDSVSIPAFIFPEDAVRSIKYMVERPNPVKKIRTAEPINQARELVKGKNYIKDFEAMQLMEIYGIRTPAYAIAENAKEAVEKSTAVGYPLVMKISPDTPVHKTDVKGVIMNVEKDTVESSFTELNYPRTIMQAQISGAEIFVGGIKDPVFGPAIVVGIGGIYMEVIKSLSYGICPVSEDEAYQMMKDSKVLGMLTSRNRDYDINGTVRAISKLSNMLIDLDIKEMDINPLIVNEKGAFAVDVRIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N683</accession>
    <name>A0A1V0N683_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1788</name>
        <name evidence="3" type="ORF">HLB00_08005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000298">
        <property type="protein sequence ID" value="NOL60769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143090.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N683"/>
    <dbReference type="GeneID" id="84218411"/>
    <dbReference type="KEGG" id="fai:FAD_1788"/>
    <dbReference type="OrthoDB" id="37025at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="369" mass="40451" checksum="D5195D01A99BFA6A" modified="2017-06-07" version="1">MLNLHINNIGISGKEFNKILPIFSYSVATFFLMDFAFFINDIVTTLHFTYIESFILLGIPFIGRMVTPFVYSYVGKIGVPRLALLAITSMAIISFIMGYETTFIELFASRFIIGIFFGLATSAAIEVSSITGDRKIIGLTMGGWAIGWLMGAIFFMILGSWELVSIAGIVFAPALLFSRKHNIISPMLKKFHFDFSIKVFLVFLLGFTPAYVLEVVPSYLGPSSFTESIIAYSIAVFAYLLLPALIIRFSLKKTLFSSLIIVAISGIIFFATTNIVFAVLFTAFGLGVNSLLPIISRNMDIDANKIGPSMNFSAVAGFIFPVVLTIGNEALNSAIAVFVAAIFLLLFYSIEFGNHGSGSKSIKKLFSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6C1</accession>
    <name>A0A1V0N6C1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A-type ATP synthase subunit F</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">V-type ATP synthase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntpF</name>
        <name evidence="4" type="ORF">FAD_1822</name>
        <name evidence="5" type="ORF">HLB00_01770</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000045">
        <property type="protein sequence ID" value="NOL59563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886972.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6C1"/>
    <dbReference type="STRING" id="74969.FAD_1822"/>
    <dbReference type="GeneID" id="16025102"/>
    <dbReference type="KEGG" id="fai:FAD_1822"/>
    <dbReference type="OrthoDB" id="24971at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD85661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL59563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="102" mass="11365" checksum="560F072F56D3B460" modified="2017-06-07" version="1">MYDLCLIGERELVAGFKLVGINDTFTADPENGKSIVKELFNSKKYNVIMVSQSFEKYMTPDEINLYAGSISPLVIFIPLPGIKEEESVYDLAKKILGIDIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6D2</accession>
    <name>A0A1V0N6D2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074049.1">
        <property type="nucleotide sequence ID" value="NZ_CP133600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6D2"/>
    <dbReference type="STRING" id="74969.FAD_1806"/>
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    <dbReference type="KEGG" id="fai:FAD_1806"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="132" mass="15486" checksum="60446144EABD71DA" modified="2017-06-07" version="1">MISVIVFLERSFKVKNVIKKNTGIQENIVVFKNLKELTHIILVISIAFITNSISFVILTENTLFFYIYFAFTSLLEIGLVDNFILVGHLSKKKLNPKLYIKKAHKINIYIFLSLIIYFVVYVYVVLHFFLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6D6</accession>
    <name>A0A1V0N6D6_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">2-phosphoglycerate kinase</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="primary">pgk2</name>
        <name evidence="1" type="ORF">FAD_1810</name>
        <name evidence="2" type="ORF">HLB00_01830</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000045">
        <property type="protein sequence ID" value="NOL59575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886959.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6D6"/>
    <dbReference type="STRING" id="74969.FAD_1810"/>
    <dbReference type="GeneID" id="16025089"/>
    <dbReference type="GeneID" id="31677300"/>
    <dbReference type="KEGG" id="fai:FAD_1810"/>
    <dbReference type="OrthoDB" id="31230at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008996">
        <property type="entry name" value="PRK12339.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477:SF3">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="198" mass="22726" checksum="0FA13E3D083E006E" modified="2017-06-07" version="1">MIPVILIGGIPGVGKTSLSGFISREFNINIILSGDYLREFLRPYADNPAMGESVYNAYRIYGEKNEENIIKGYLNQSEFMYKGINAVLRRSIDNGEPLILETLYFNPEMIASDIRNKIIMIYIHIPDKSLHGNRLKERIDYTHFNSPGERLVEQLPVYSVIEKYSMDHCGDDVFIVDNTDFPITKNTLINYIKGQINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N6G1</accession>
    <name>A0A1V0N6G1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Isopentenyl phosphate kinase</fullName>
            <shortName evidence="10">IPK</shortName>
            <ecNumber evidence="2 10">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FAD_1830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>isopentenyl phosphate + ATP = isopentenyl diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="2 10"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_236940574.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N6G1"/>
    <dbReference type="STRING" id="74969.FAD_1830"/>
    <dbReference type="GeneID" id="31677320"/>
    <dbReference type="KEGG" id="fai:FAD_1830"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04241">
        <property type="entry name" value="AAK_FomA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040647">
        <property type="entry name" value="IPPK_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="ISOPENTENYL PHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="5"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ARD85669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="242" mass="27280" checksum="7713F6D5A6BC7690" modified="2017-06-07" version="1">MIVIKIGGSIITDKSMYKKFNGQIVENIVKTLKRIDKQMVIIHGGGSFGHIKSKEYGLPGQVSERTMEGMNIVHNDMAELDLKISKIFQENKIYNISLPVSSLVYNNKKNYNIFSKYLELGITPISYGDTYIHGNEIGIYSGDNIAYDISKILHPEFVIFFSDVDGIFDKNPKNNPDAKLLKTISTDFQYDTINPDVTGGIMNKYNKMKLISDIGIPVYLINGLYPERIYNIGKDNFTGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1I6</accession>
    <name>A0A1V0N1I6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rsmA</name>
        <name evidence="7" type="synonym">ksgA</name>
        <name evidence="10" type="ORF">FAD_0048</name>
        <name evidence="11" type="ORF">HLB00_02660</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Berkeley</strain>
            <strain evidence="12">Y</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7 8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
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        <property type="protein sequence ID" value="ARD83983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="84218539"/>
    <dbReference type="KEGG" id="fai:FAD_0048"/>
    <dbReference type="OrthoDB" id="9883at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD83983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="NOL59735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="239" mass="27176" checksum="E5316C97CD205809" modified="2017-06-07" version="1">MTVNFSKKYGQVFLNDKNIAAKEVRLLGIEPGDHVLEIGPGHGILTGILLSEPVKLTAIEPDHRFYESLKISYHDHIASGKFNIIKESFLDTEPSYFDHIIGNIPYNISSPILFKILDFNFKSSILMVQKEFARRLVAKPGTKEYSRITINTSVRSTIKILFNVTRKVFSPVPDVDSAVISIIKKDVDIDLANFDKFIAKIFSMRRKKLSTILNYNGPLSEKRPEELDLSQLLTLYSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1P4</accession>
    <name>A0A1V0N1P4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oligopeptide ABC transporter Dpp2, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FAD_0094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1P4"/>
    <dbReference type="STRING" id="74969.FAD_0094"/>
    <dbReference type="GeneID" id="31675606"/>
    <dbReference type="KEGG" id="fai:FAD_0094"/>
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    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30465">
        <property type="entry name" value="INNER MEMBRANE ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30465:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="271"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD84027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="338" mass="38423" checksum="059BDBF1986860FA" modified="2017-06-07" version="1">MENQKPVNILAKYFFIFIGFTILLFIIYKFVPVIILKKDYPGTSINALGLHENDFFQYFYFLYALITGKMGNVNTLIYSGTVKSAVSIILPETIFFLVITFLISYALAYLIGFYSGTAFRTVRRLSMSIFPLLFLYMVSGLTLVTVFAGIMGWFPSGSILSIHSIIGHSWISYSGQGLFITSPTNIIILDSLIHHSPVVLFDYLKHMVMPFIALLVPTTIYLSVYISHEASIVYNSSFMRAGTTRDAFRDNYILYVKRGIRSRLLEELKPVFLIFIGGLVLISFVFSYMNLGEFAVYSFMNYNFGFMGGLYSVFMLAIIVIIFDAIIDLLNREVKHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Q3</accession>
    <name>A0A1V0N1Q3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="16025297"/>
    <dbReference type="KEGG" id="fai:FAD_0150"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="72" mass="7838" checksum="0BAE3342A72BA7CA" modified="2017-06-07" version="1">MTVKLENLNKKLFSMPLLGMFALLLAFNPDSTGSIVSGFYADGYAVDLFMLAVAIAFIAALIILKFKGKFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1U5</accession>
    <name>A0A1V0N1U5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c oxidase assembly factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141371.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1U5"/>
    <dbReference type="STRING" id="74969.FAD_0145"/>
    <dbReference type="GeneID" id="31675657"/>
    <dbReference type="KEGG" id="fai:FAD_0145"/>
    <dbReference type="OrthoDB" id="36231at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="258" mass="28560" checksum="2538BECA37C1EE08" modified="2017-06-07" version="1">MNVILYYYFVFQVILAFGIVIVGGTVEGYGYGLSLGTKWPYTKDMPLKAKAGDPEVWHRILATLLGVDAVIMVVLIHGALEITGLILVVLTALLGMATLYTLAGKAPSVVQGLHDILAYSTALTYLLIIYPVAGNVLDLVIHNIPLYFFFAVIYMGGMTTGERGYQKAIGYFKIPKTRAQWIWTIHGLAVLLFLFTLILFFFTYNVALIIIGVQIIVGIIVFISVNKSASRPGFIIPMHQFFTILIVLSIVFQLSIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1V6</accession>
    <name>A0A1V0N1V6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FAD_0155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141382.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1V6"/>
    <dbReference type="STRING" id="74969.FAD_0155"/>
    <dbReference type="GeneID" id="84218644"/>
    <dbReference type="KEGG" id="fai:FAD_0155"/>
    <dbReference type="OrthoDB" id="56564at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13842">
        <property type="entry name" value="CuRO_HCO_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888:SF9">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="CYTOCHROME C OXIDASE, SUBUNIT II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II copper A binding" evidence="9">
        <location>
            <begin position="129"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="276" mass="31164" checksum="43AEF29C82B69138" modified="2017-06-07" version="1">MFEIYNIIPSVYHLIPRGSITGAEITSIFLAYVLPGILIGGGFALWYVYVFLKSYKPKNADEFEKEKYNKDMDMRPGRIENLERGNKTIFKIFVLFVVLILLSLLVYDLPPAYGIRVAGAAPSAPTDSHHYMDINVVGYQWQWVFIYPNGASSRHFLVLPADTPIQFNVTSVDVMHSFYLINVTKVDAFPGHYNYVWSNITLTGEYQFECVELCGLGHAHMRGQAFVLPKAQYESWLNTTRGGEMVEQFHVGTYSENYGPNNYDNGTVITPPSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N1Z9</accession>
    <name>A0A1V0N1Z9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="3">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cbf5</name>
        <name evidence="3" type="synonym">truB</name>
        <name evidence="7" type="ORF">FAD_0186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887191.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N1Z9"/>
    <dbReference type="STRING" id="74969.FAD_0186"/>
    <dbReference type="GeneID" id="16025334"/>
    <dbReference type="KEGG" id="fai:FAD_0186"/>
    <dbReference type="OrthoDB" id="35866at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07953">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01081">
        <property type="entry name" value="TruB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026326">
        <property type="entry name" value="TruB_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="5">
        <location>
            <begin position="215"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="351" mass="39457" checksum="ADE4AAB993634788" modified="2017-06-07" version="1">MYASNSTPEEINGFIVIDKPKGPTSHQIDAWVREITGEKRVGHIGTLDPNVSGVLVMALGKATKLIDIVHERPKEYISVMRLYSTADTDNIMKVFKEFTGKIYQLPPVRSAVSRQVRERTIYNMDVLEIQEKLILFRVKCESGTYIRTLCTDMGYVIGTGAQMADLRRLSTGQFNESHIHTLQELSDSVVLKKQGDTSLFDNMVIPMDFVFADSPKVVVKNTAIKNIMHGSDIYPSGIKALIGDIHKGSRVAIYSGDNELLAFGTMLVDSLNDLKAVDLDGILSDKYGENNVVRKNNRQKNIPVQKPAKRLHEHIRKPEARDNPGNGRDMFRKNPGFKGNPSKIRKRKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N278</accession>
    <name>A0A1V0N278_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase I/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141488.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N278"/>
    <dbReference type="STRING" id="74969.FAD_0316"/>
    <dbReference type="GeneID" id="31675825"/>
    <dbReference type="KEGG" id="fai:FAD_0316"/>
    <dbReference type="OrthoDB" id="33550at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="416" mass="48004" checksum="2B8D06158988F57C" modified="2017-06-07" version="1">MINHKLEYRYKSDAHFVYPDYDGYNFSNINSTILSLFNIKHDGKDLDKKLYSNICGTKKVVFIYIDGLGYDSWINYLGKYRAFKEINESGIVSPITSIFPSTTAAASNTINTGLTPAEHGLFEWRLYIDQYDMVMKSLPFIPVYKQDREKFIEANPNPSVLFHGKTFYETLKENGIKSYVVSRSELLKSSYSRIMYSGAKEKKRYDFLFEGFLILKKLLEKIKDNSYVFFYIEEPDKMEHRYGPGSPEHLESLHYMAGLFNSLFENLSGQDISIIISSDHGFTPVNHKTYVSGVENLMSTKNGKRMPETWSPRDMAMYSENPEKLKLFLENQLNGKADVITKLELLESGILGSRKVDEKYASRLGDVIVLPYSGNTVWYKYYEDDIIKDRGMHGGLSREEMIIPLATINLKDIKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N287</accession>
    <name>A0A1V0N287_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FAD_0295</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Y</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887317.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N287"/>
    <dbReference type="STRING" id="74969.FAD_0295"/>
    <dbReference type="GeneID" id="16025464"/>
    <dbReference type="KEGG" id="fai:FAD_0295"/>
    <dbReference type="OrthoDB" id="53073at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000004">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="NCBIfam" id="TIGR01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD84217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="213" mass="23737" checksum="282122E1EC209513" modified="2017-06-07" version="1">MEISPSIISSNLLELGTQIKECQDAGAGSFHLDIMDGHFVDNITMGPDLVAAIRKGTNLRLDCHLMIERPDRYYKSFINAGADVLLIHYETPIEVINLIKKFQDENIRYGIVINPDTDVKKIYKLIPGSEIVLVMSVFPGFSGQKFIEKSLEKVKALREFIDENNYSTRIEIDGGINNETGKLAVEAGADILVSASYIFKNGINESIKKLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2B4</accession>
    <name>A0A1V0N2B4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cdc6-1</name>
        <name evidence="8" type="ORF">FAD_0327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887345.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2B4"/>
    <dbReference type="STRING" id="74969.FAD_0327"/>
    <dbReference type="GeneID" id="16025491"/>
    <dbReference type="KEGG" id="fai:FAD_0327"/>
    <dbReference type="OrthoDB" id="195574at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055237">
        <property type="entry name" value="Cdc6_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02928">
        <property type="entry name" value="orc1/cdc6 family replication initiation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001625">
        <property type="entry name" value="PRK00411.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22703">
        <property type="entry name" value="Cdc6_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="53"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="7">
        <location>
            <begin position="301"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="422" mass="47075" checksum="EEB821F06596C514" modified="2017-06-07" version="1">MDNPFIKYNKSNDYVVGDLKKLSSSYIPDNFPHREKQIDSIARVLSSIVTGGLSSNLLLYGKSGSGKTSSVIYVTGMLKETLKGNINIIYINCEIYDSQYSILVYLTNAINSGDAPIPILGLPQDKIYFELVKRLNKSGRYTVIILDEIDKLIQKSGSDALYVLLKIMADSNTSLIGITNDASFVNALDARVQSRLNQESIIFPPYNAMELRDILNFRVSGIIKDGFITEASINLCAALGAQEHGDARKSIDLLRIAIDSALKDGKDCVTIDDVYLARDRFEMNVLKESIRTLPIHSKMVLLSACLTQETDADLSVTGEIYENYGNICTELGFQPLTMRRISDLLSDLEDTGLLTTNTRSLGRYGRMKFIRVMGSIQNVKGYTLEDPAFVNFQGSKIVRQSKLRTNFDAYVETYKNGDFDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2B8</accession>
    <name>A0A1V0N2B8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2B8"/>
    <dbReference type="STRING" id="74969.FAD_0314"/>
    <dbReference type="KEGG" id="fai:FAD_0314"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051460">
        <property type="entry name" value="HdrC_iron-sulfur_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43255:SF2">
        <property type="entry name" value="HETERODISULFIDE REDUCTASE RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43255">
        <property type="entry name" value="IRON-SULFUR-BINDING OXIDOREDUCTASE FADF-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich" evidence="1">
        <location>
            <begin position="187"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="286" mass="32665" checksum="6C7CB8DE6024ABF4" modified="2017-06-07" version="1">MKDLISQNLMESFLPFPLDTKLYSSWASGLPHDGETIIYTSYMYQISGILKRYEELFPKIYRLNLPKRLMTASKFLIKPNRDELDRSFNILKNITSMLTAQGLNFGYLYDEEPYSGALLLESGFINEYKEYGKKLYNFFKERGVKQIITVDPHTTNALKRYKDFIDFDIDIKNYLELVNFKGSGNYVIHDSCLYSRAMGMYDNIRAKIKDSGISASENYLVTGKDMGSCCGGPLALVSTKDSEDISKSRAEKLLSVNENVLVMCPLCYQNLSPYVNNIKDIAEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2C7</accession>
    <name>A0A1V0N2C7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-4 C11-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2C7"/>
    <dbReference type="STRING" id="74969.FAD_0335"/>
    <dbReference type="KEGG" id="fai:FAD_0335"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF4">
        <property type="entry name" value="COBALT-PRECORRIN-4 C(11)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="192" mass="21502" checksum="5EC18C39E0200F2F" modified="2017-06-07" version="1">MLVKKYYDEGLDITRLHSGDPSIYGAINDEIQFFNSNGMEYEIIPGISSVFAAAASMGMELTSPGTTQSVILTRVPRRTEHFENEELDILASHKTALAIFLSASNARAVTEKLIKGGYKGDDRAVIAYRVSWPDQKIIETTINGLEHSLFENRINRQALIMVGGNISYNSDKKSYLYNPDFTHLFRKSSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2I6</accession>
    <name>A0A1V0N2I6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141604.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2I6"/>
    <dbReference type="STRING" id="74969.FAD_0447"/>
    <dbReference type="GeneID" id="31675956"/>
    <dbReference type="KEGG" id="fai:FAD_0447"/>
    <dbReference type="OrthoDB" id="110773at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053172">
        <property type="entry name" value="Tn903_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053520">
        <property type="entry name" value="Transposase_Tn903"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033579">
        <property type="entry name" value="transpos_IS5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34631:SF3">
        <property type="entry name" value="ISSOD12 TRANSPOSASE TNPA_ISSOD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="127"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="307" mass="36219" checksum="AFC663BD17A2198A" modified="2017-06-07" version="1">MTPQINNKINRSIKRYWIGSNRRWEKYNESLVDRIQYLTDLSFIKDYDTLLEEKNNGKIGHPYKVPDALIMYLARLRSIFNIPFRSLEGMLRSLAIITGIKSISYSEIFRRIRRIKPEINNTNSKLDCIIDSTGYKITIRGDYLGHKWHKKRKGWIKLHVIISLKDVTVLSFTITDEHTHDSKAARKLLSKMKNNILRIFGDKGYDSKYIYNMFGYNAVIPPRKNASTKSRGSSARAKIVRYIKKNSMEQWKENNSYGKRWIVEIYFSGLKRVMTEVIKAKKIEYIIQELALKVVNYNIMREMTHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2K8</accession>
    <name>A0A1V0N2K8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2K8"/>
    <dbReference type="KEGG" id="fai:FAD_0417"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011470">
        <property type="entry name" value="PRK14887.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="74" mass="8647" checksum="0319B97862EE92DF" modified="2017-06-07" version="1">MLLLLFMELCISIDEDNCNALYNSLIQDNNQDIEMECTNNKLIIKIINVKLSSIYNLVDDIIRDYETYKKVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2L9</accession>
    <name>A0A1V0N2L9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sugar nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0496</name>
        <name evidence="3" type="ORF">HLB00_03960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000130">
        <property type="protein sequence ID" value="NOL59988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887552.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2L9"/>
    <dbReference type="STRING" id="74969.FAD_0496"/>
    <dbReference type="GeneID" id="16025699"/>
    <dbReference type="KEGG" id="fai:FAD_0496"/>
    <dbReference type="OrthoDB" id="57547at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="105"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="266" mass="30515" checksum="7BAAE080E5633DC2" modified="2017-06-07" version="1">MSKILILDGDESFGFRFAKDYGDANKIQSLFPLKGIEKFAESLMELHDDYDFIINNFDIPFYSKNKNYIEMNYGIQGLINEKFQNGKKILLSNQLVYSSSSAIKNEESATIPETEYGKAKLKAEELAKGNEHYLIIRRGMTYGKCTYNIYTDILAAIRSKMPIKLNNDIIINPVLNSDLSIGVYKAMRDMDRGIINIAGEETMTLYEFGRKLYYSIRDEPCPFIKSYLGQNLDYSIDSSRAEKLYGLNFTGLEVVDFMDFQTYKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2N1</accession>
    <name>A0A1V0N2N1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1805 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0442</name>
        <name evidence="2" type="ORF">HLB00_03830</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000124">
        <property type="protein sequence ID" value="NOL59962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009887495.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2N1"/>
    <dbReference type="STRING" id="74969.FAD_0442"/>
    <dbReference type="GeneID" id="16025644"/>
    <dbReference type="KEGG" id="fai:FAD_0442"/>
    <dbReference type="OrthoDB" id="120833at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1980.10">
        <property type="entry name" value="Hypothetical protein YunC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014931">
        <property type="entry name" value="DUF1805"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036493">
        <property type="entry name" value="YunC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08827">
        <property type="entry name" value="DUF1805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102891">
        <property type="entry name" value="Hypothetical protein Ta1206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="95" mass="10355" checksum="2D75F2CBC1C01F14" modified="2017-06-07" version="1">MINQEIEIKGRKYQYINEKIGKKAPLIIVKGENGYIMCGYLNIDAANSLGDVAVRVSGVNDINDVLNTSVNACTDKAKELGIKPGDSIMDIVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2N9</accession>
    <name>A0A1V0N2N9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arginine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2N9"/>
    <dbReference type="STRING" id="74969.FAD_0428"/>
    <dbReference type="KEGG" id="fai:FAD_0428"/>
    <dbReference type="OrthoDB" id="371705at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019546">
        <property type="term" value="P:L-arginine deiminase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47271">
        <property type="entry name" value="ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47271:SF2">
        <property type="entry name" value="ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02274">
        <property type="entry name" value="ADI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="415" mass="46988" checksum="35A0C3AC51B44A74" modified="2017-06-07" version="1">MEIKSEWGHLNRVIMHRPGTEITYAMLAPKPFLFERPFNYSIANKEHQNLEDTLRENGVKVDLLENLIVDEAEKKASFRQKLEEKIMALVNFYGTMESVEEAKKDMEKNIKYVDPLSLFQALIMEPSIDLKEYVPGIQYPRVYSNLPLANLYFMRDQQAVSSGVLLGKMKMQQRRKETDITSFVFSEILGAKTKKITEGFFEGGDFIPCGDFCLIGTGNRTDETGAMEAINSGIFNFPRVAIITNPLYDFMDGHDVMVNMHLDTYFNIPAKGMAITSVELARVARAKIYTRDREGHYAQETETTLYDFLKGEGYEFINLGISEQLSYSSNFLTLSDRKIVAIDSSKVIKKLLAENVFDTDTRQKIIKDMELKSGKMFPDSDAMAKSGIDVIKIDLSEITGGYGGAHCMTSAIDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Q0</accession>
    <name>A0A1V0N2Q0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative [LysW]-lysine/[LysW]-ornithine hydrolase</fullName>
            <ecNumber evidence="8">3.5.1.130</ecNumber>
            <ecNumber evidence="8">3.5.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">lysK</name>
        <name evidence="10" type="ORF">FAD_0509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:48684"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:9715"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:78526"/>
            <dbReference type="EC" id="3.5.1.130"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:52676"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:13328"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:136763"/>
            <dbReference type="EC" id="3.5.1.132"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) or Co(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M20A family. LysK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.130" evidence="8"/>
    <dbReference type="EC" id="3.5.1.132" evidence="8"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141643.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Q0"/>
    <dbReference type="STRING" id="74969.FAD_0509"/>
    <dbReference type="GeneID" id="31676017"/>
    <dbReference type="KEGG" id="fai:FAD_0509"/>
    <dbReference type="OrthoDB" id="133929at2157"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00039"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01120">
        <property type="entry name" value="LysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010175">
        <property type="entry name" value="LysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01902">
        <property type="entry name" value="dapE-lys-deAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF28">
        <property type="entry name" value="[LYSW]-LYSINE_[LYSW]-ORNITHINE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="155"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ARD84423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="355" mass="39146" checksum="C136C554310611EB" modified="2017-06-07" version="1">MNPKDMLIEMLNIYSPSGKEGEIAKLLKEYMVDLDFEEPVIDDQLNVISVNGKGSPAVFLCGHEDTVPGILEVKSDGNMVYGRGAVDAKSSLLALILGARKAMDNGFKGKLLVSAASGEESDSKGINNIMENYHGYDYAIFGEPGGSMNITAGYKGRLLMKVDVKTATHHASSSWMESNAIDLLMGLWVKIREQYGNNKDFNSVSAGITRFNGGEYDNMTPEHASMYIDIRYPKSVSEDELTGELKSYMEELLVKNYSYTIESRTYPYISDMKSSLVKSFKSGISRNGMAPRLIFKSGSGDMNNLGHVWKIPAITYGPGDTQLSHTQNEVIDIRDLYKSIDVISDSLVSMQLDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Q6</accession>
    <name>A0A1V0N2Q6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Q6"/>
    <dbReference type="KEGG" id="fai:FAD_0526"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="115" mass="12429" checksum="8064A89ABCE2B661" modified="2017-06-07" version="1">MSKMARNKHKGIIVLVIIIVLALLIYGLIPTILNTSPSAMKDNNSYYLAGKITQDVTVNGQSAFTLNDNGKSITVLYNGTASVNSFVLVHGTYQNSLLGSYINSSSVTPWLYSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2T7</accession>
    <name>A0A1V0N2T7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfur oxygenase reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141656.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2T7"/>
    <dbReference type="STRING" id="74969.FAD_0535"/>
    <dbReference type="GeneID" id="31676042"/>
    <dbReference type="KEGG" id="fai:FAD_0535"/>
    <dbReference type="OrthoDB" id="37893at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011661">
        <property type="entry name" value="S_Oase_red"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047630">
        <property type="entry name" value="SulOxRed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07682">
        <property type="entry name" value="SOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="307" mass="34694" checksum="F0FAA3651B2F7772" modified="2017-06-07" version="1">MPKPYVAINEVEMLNNDTTMQMFQQVGPKVCQVTARHPGFVGFQNHVQFGIIPMGTRWGGGSMDMTKMDTMNVYQYTMWKSIKDHEDMHRENFSSIFRLCSSCLSQVVYGPWEPLYEIVDASMPLNTEMADFTTMFGKKFAAGDPAGVPPISMPYGQRTIALSEHTVKKDKEKEFESTIVEVMKDFEKAPGFLGYMILKEVGVSAVGSFQLKSKGIHETLESGGEVPTQQEGSFKPEEARPTPPEYKVHMEWASPNDAMFGIGRVLFAHPAREIHDKVLDTLIRGPYIRLLNPMMEGTTWREYLNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N2Z5</accession>
    <name>A0A1V0N2Z5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS605 OrfB family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141664.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N2Z5"/>
    <dbReference type="STRING" id="74969.FAD_0545"/>
    <dbReference type="GeneID" id="31676051"/>
    <dbReference type="KEGG" id="fai:FAD_0545"/>
    <dbReference type="OrthoDB" id="56643at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF11">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE RV2885C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas12f1-like TNB" evidence="2">
        <location>
            <begin position="243"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="349" mass="39801" checksum="0CF34FEFDB3798A8" modified="2017-06-07" version="1">MILTYKIKHGKDFSEELNKARLIAEFAIKTKSIISRDVKQFGLKSAISNQILRKYSRNSKAKDVHKIKLTVPHQGIKCNQIDRTINITPLKLTLNYYFRNDFDKISQIELDNKFAYVSINIPDNDLIEPNGYLGVDRNTTGHIAVAGNPETGKIIKLGKEAGHVHKKYKNMRKNLQKKGKYRKAKRIKNRESRIVKDINHKVARKIVQEAKDNGMGIKLEYLNGIRNAKSGRSFRYSLNSWSFYELKNMIEYKARLLGIPVAYVDPYNTSKEYSRCGQIGNRSGKSFKCNNCGHVDHADANASFNIALRPVFEEGIDQLYVDRDAYKGNTGIPEEATLGTMATLEPHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N357</accession>
    <name>A0A1V0N357_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">NADH dehydrogenase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_0623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
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            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
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            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84534.1"/>
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    <dbReference type="OrthoDB" id="23478at2157"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004545">
        <property type="entry name" value="PRK05888.3-1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF35">
        <property type="entry name" value="FORMATE HYDROGENLYASE SUBUNIT 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0408">Iron</keyword>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="165" mass="18999" checksum="38C5072349744A23" modified="2017-06-07" version="1">MVATVKEIKMPKKPIPVVGSLKSMLSMGKYVFTKPVTTQYPEDKGKIPERFRFRIFLVPEACVGCTLCSKICPNHSIKMEHWDLDRTGLEDNVVQTARGDRKNLQNKRNIYPDVNFGTCTVCRQCEEICPTDAIYLTHQFEDARTRNSFTYSPEELTMQEEDVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N368</accession>
    <name>A0A1V0N368_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">FAD_0630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
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        <lineage>
            <taxon>Archaea</taxon>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N368"/>
    <dbReference type="STRING" id="74969.FAD_0630"/>
    <dbReference type="GeneID" id="31676135"/>
    <dbReference type="KEGG" id="fai:FAD_0630"/>
    <dbReference type="OrthoDB" id="56064at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="112" mass="13246" checksum="78914468356C6B32" modified="2017-06-07" version="1">MNTEDVIEIFKTSLVNGDVNNAYKIVERNRKIYTKRGLKTAEEFMQYLIDALKGDKTPDDLYNIFSDEKYNIFPYIHDYKGYVFNLVDTILYSINRYNIKYPSFDGKRCGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3D8</accession>
    <name>A0A1V0N3D8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_0678</name>
        <name evidence="2" type="ORF">HLB00_03785</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141781.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3D8"/>
    <dbReference type="GeneID" id="31676179"/>
    <dbReference type="KEGG" id="fai:FAD_0678"/>
    <dbReference type="OrthoDB" id="57108at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD84586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL59953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="114" mass="13333" checksum="E5D8E80733C0B152" modified="2017-06-07" version="1">MNPKLEEAIAGLRCVNKPVKQIAKTLGVKKDAIEKIIKEWIMDTDPYINKLVGERKVNNIPDANEMKLLVKMAPDDLLSDKRILDYIAKKRNDHHDRFMDCIRYKIKIMLENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3F2</accession>
    <name>A0A1V0N3F2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_0780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141958.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3F2"/>
    <dbReference type="STRING" id="74969.FAD_0780"/>
    <dbReference type="GeneID" id="31676282"/>
    <dbReference type="KEGG" id="fai:FAD_0780"/>
    <dbReference type="OrthoDB" id="40089at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000018">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696:SF1">
        <property type="entry name" value="CYTOCHROME P450 YJIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="369" mass="42284" checksum="C7DEB0842D234756" modified="2017-06-07" version="1">MEHDVFQYYRKMRKESPVHFNNDTGSWDVFDYKSVYFVLMNPDTYSSDPSYAGNIPENRQGPGASFITMDNPDHKELRNVTVPYFLTSKITGYRDMIESTSRKLMAGINKDSDFIRDYAVMLPVTVISELLGVPENDRSKFKEWSDYIIGNRSDAGIQDLNRYMYSTMAEIFKTNTEDNIISTINKGLYHSEPLSINQKIGYVMLLVIGGNETTTNLIGNMVKVLSEHPEIADKLRQEPELKKGFIEETLRYYSPIQFLPHRFAARDSVLNGQEIKKGQRLSIWLGSANRDGTKFEDPDTFNMEREKNDHLAFGMGIHMCLGSPLARLEAEIALNDILNKFKHVKINAEKTAMLKNPMVYGFSTMQLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3G9</accession>
    <name>A0A1V0N3G9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="4">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="4">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sucD</name>
        <name evidence="7" type="ORF">FAD_0710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="4"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141823.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3G9"/>
    <dbReference type="STRING" id="74969.FAD_0710"/>
    <dbReference type="GeneID" id="84217333"/>
    <dbReference type="KEGG" id="fai:FAD_0710"/>
    <dbReference type="OrthoDB" id="55711at2157"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000006">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000277">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4 5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="16"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD84616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="284" mass="29923" checksum="CEEC23EF1F29875C" modified="2017-06-07" version="1">MVIISKETKVIVQGMTGHQGAFHSGEMIKFGTNVVAGVSPGKAGTKVNGVDVYNNVADTLDLKPDASMISVPAPFVKDAALEAIENGIKLIYILTEHVPVHDTMELYHEARRKGVFMIGPNSPGITVAGQAKIGIMPNNIFRVGDVAVASRSGTLTYEIVKAVTDAGFGESTVIGLGGDPIIGTTFSDIIKIFNEDPQTKQIVLVGEIGGSEEEKAAEYIKKYVKKPVTGYITGISAPPGKKMGHAGAIIEKGTGTADSKIKAFKDAGIKVANYPDDIPSLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3J9</accession>
    <name>A0A1V0N3J9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FAD_0753</name>
        <name evidence="5" type="ORF">HLB00_06835</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Berkeley</strain>
            <strain evidence="6">Y</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000242">
        <property type="protein sequence ID" value="NOL60546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081141916.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3J9"/>
    <dbReference type="STRING" id="74969.FAD_0753"/>
    <dbReference type="GeneID" id="84217373"/>
    <dbReference type="KEGG" id="fai:FAD_0753"/>
    <dbReference type="OrthoDB" id="43333at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="74"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD84657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="NOL60546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="140" mass="15697" checksum="34AE1E4704476AFF" modified="2017-06-07" version="1">MVLYAEDIMRKNCQIINGNTSALEGSKHMAENREGYIIVGDGKIPEGIVTEWDYINKVLSQEADPSRVLLKEIMTAPLTSVTSDTPMEKVASLMAKKAIRRLLVIDNNKLSGIITSRDILKFFNEYVEDMVEIASKFGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3Q8</accession>
    <name>A0A1V0N3Q8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysK</name>
        <name evidence="8" type="ORF">FAD_0825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142024.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3Q8"/>
    <dbReference type="STRING" id="74969.FAD_0825"/>
    <dbReference type="GeneID" id="31676326"/>
    <dbReference type="KEGG" id="fai:FAD_0825"/>
    <dbReference type="OrthoDB" id="10138at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000006">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD84725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="317" mass="34389" checksum="DA12DBB7677B2A1C" modified="2017-06-07" version="1">MDDVRASVLSTIGNTPLVKLNRTGCRNIEIYVKLEYYSPGFSIKDRIAIGMIEDAERKGILKKGDTVIGKTSGNTGIGLAIACAVKGYKFITVMSAGNSMEKTVMLKALGAHVVLVPQQPGEEPDVVSRKDNEAVEKKTDELTEELHAYRPNQYINPVNYLIHEYTTGSEIIKQSDGNIDAFVAFVGTGGTFVGISSALKKFRKDIKCYPVEPDSAQFLAGKQVITTRHKIQGGGHAVKPPYWDESLVDGYLSVTDDEAIDTARHLASKEGIFPGFSGGANVAAAMKLDKTMDRGSIVVTVLPDSGLKYLSSDLYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N3V3</accession>
    <name>A0A1V0N3V3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_0875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142106.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N3V3"/>
    <dbReference type="STRING" id="74969.FAD_0875"/>
    <dbReference type="GeneID" id="31676379"/>
    <dbReference type="KEGG" id="fai:FAD_0875"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43242">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43242:SF1">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="275" mass="31297" checksum="281F64FC34519AC8" modified="2017-06-07" version="1">MKTLIIGSGGQLGKALSSILENSIPLSHDDIDLRNVNNIENILDKYDFDTIINCAAMTSVDKCETDIESAYYINGLSMKYIANYCRENNKYFIHVSTDYVFTGNKGNYTEDDIPYPVNYYGLSKLIGDTYVNSYKDSLIIRTSGVYGSKNNFPLYVIDRLRNNQKVNAFDNYYSPVNANVLAYSILKIINLKLTGILNISGDRFSRYEFALKIADKFGLNEALINKTDYNSVKSIAKRPYDSSLNNEKAKGILKFNFDDLDYNLNEFKKNMDNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N409</accession>
    <name>A0A1V0N409_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIN-domain RNase, VapC-type toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FAD_0958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142236.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N409"/>
    <dbReference type="STRING" id="74969.FAD_0958"/>
    <dbReference type="GeneID" id="31676459"/>
    <dbReference type="KEGG" id="fai:FAD_0958"/>
    <dbReference type="OrthoDB" id="168412at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051619">
        <property type="entry name" value="TypeII_TA_RNase_PINc/VapC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901:SF1">
        <property type="entry name" value="EXONUCLEASE VAPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901">
        <property type="entry name" value="RIBONUCLEASE VAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD84841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="143" mass="16327" checksum="1E97B7B2BD56E18F" modified="2017-06-07" version="1">MKGNIDYTFVVDTSSLFNLFFIDSKNIVLEIMHKSFILDLTFYELGSVFVKGNDNHIKNLNKTEITELINNIEKLISGINVIRIQPEHISGIMHISFSTGLTFYDSSYVFYSKNLNLPLLTDDKEINSKAKKLGINVMKVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4I1</accession>
    <name>A0A1V0N4I1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF929 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD84999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142493.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4I1"/>
    <dbReference type="STRING" id="74969.FAD_1123"/>
    <dbReference type="GeneID" id="31676620"/>
    <dbReference type="KEGG" id="fai:FAD_1123"/>
    <dbReference type="OrthoDB" id="57485at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009272">
        <property type="entry name" value="DUF929"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06053">
        <property type="entry name" value="DUF929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD84999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30596" checksum="A9040A5B728E41B7" modified="2017-06-07" version="1">MASKNNKKNNKSTKKNTTKKEGYAGFIKSRNFKWTVIGTAIIVVIVLVAVFNPFFEPPASIHPGIYYKVSDGDLLSNGSSAVFFLSWIGCPIGATDSWAIYSAINSTSDIYSHVILHSAYKKDIYSNGVTGQPGLLFKGNFTFTTSGHKFTFYPLYMYNQTMTGTVNNTTINGTLASYGLSLINQTYPAKVAAMFNRYAADITYKGHLETTFIITGPHGTYILNAFMYDPVSGGILGTGSPDYPNWTPNSPQYVWSHLSESKSITKAAGTFMGYLDKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4N4</accession>
    <name>A0A1V0N4N4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1193</name>
        <name evidence="2" type="ORF">HLB00_06380</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Berkeley</strain>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000222">
        <property type="protein sequence ID" value="NOL60458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048074024.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4N4"/>
    <dbReference type="STRING" id="74969.FAD_1193"/>
    <dbReference type="GeneID" id="16024421"/>
    <dbReference type="KEGG" id="fai:FAD_1193"/>
    <dbReference type="OrthoDB" id="376945at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="NOL60458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8781" checksum="77A5D4818A8858A8" modified="2017-06-07" version="1">MGVESMKDVKLIAEKNIKDMYGENISNFTINSIVDNSDRYDVSTEFDYAGFHYTVYLSIDDDGNVTKFNQIAKAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4P4</accession>
    <name>A0A1V0N4P4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NfeD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1239</name>
        <name evidence="3" type="ORF">HLB00_06080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000206">
        <property type="protein sequence ID" value="NOL60400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142652.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4P4"/>
    <dbReference type="STRING" id="74969.FAD_1239"/>
    <dbReference type="GeneID" id="84217835"/>
    <dbReference type="KEGG" id="fai:FAD_1239"/>
    <dbReference type="OrthoDB" id="56901at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141322">
        <property type="entry name" value="NfeD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL60400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="101" mass="11611" checksum="8D619E8B7FC02AF6" modified="2017-06-07" version="1">MGQIIIIGYILDTIVAFFIGAWFSRFWLRHPFRRKPATGKDSLVGKTGEIKLTLKNNFYEIAVDSQLWRAVPDDPGETFEKGEIAYVKSVRDLTLYISKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4P6</accession>
    <name>A0A1V0N4P6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">udgB</name>
        <name evidence="11" type="ORF">FAD_1237</name>
        <name evidence="12" type="ORF">HLB00_06070</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Berkeley</strain>
            <strain evidence="13">Y</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 28986</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000206">
        <property type="protein sequence ID" value="NOL60398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142651.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4P6"/>
    <dbReference type="STRING" id="74969.FAD_1237"/>
    <dbReference type="GeneID" id="84217833"/>
    <dbReference type="KEGG" id="fai:FAD_1237"/>
    <dbReference type="OrthoDB" id="8612at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051536">
        <property type="entry name" value="UDG_Type-4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33693">
        <property type="entry name" value="TYPE-5 URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33693:SF3">
        <property type="entry name" value="TYPE-5 URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="43"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ARD85108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="NOL60398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="220" mass="24810" checksum="4561066EBA948620" modified="2017-06-07" version="1">MNIEKLNREIISCRKCTRLVEYRSSRSPRAGFAGETYWNKPITGYGSIGSRILIVGLAPAFDGGNRTGRIFTGDKSSDFLISSLYAAGLANMPTSERKDDGLKYIDTYITLALKCAPPDNKPEKEELNNCSGFFEKEIEQMENLKAILCLGKIAFDSTLKFFRAHQINTRGIKFIHGKYYNIGGVRLYCSYHPSPRNVNTGLLRKEEFISLLKKIRNFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4S1</accession>
    <name>A0A1V0N4S1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="12">PEP synthase</shortName>
            <ecNumber evidence="12">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ppsA</name>
        <name evidence="16" type="ORF">FAD_1233</name>
        <name evidence="17" type="ORF">HLB00_06050</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Berkeley</strain>
            <strain evidence="18">Y</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>pyruvate + ATP + H2O = phosphoenolpyruvate + AMP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="12"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000205">
        <property type="protein sequence ID" value="NOL60394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142645.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4S1"/>
    <dbReference type="STRING" id="74969.FAD_1233"/>
    <dbReference type="GeneID" id="31676731"/>
    <dbReference type="KEGG" id="fai:FAD_1233"/>
    <dbReference type="OrthoDB" id="23397at2157"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000010">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005057">
        <property type="entry name" value="PRK06464.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030:SF1">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="14">
        <location>
            <begin position="21"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="13">
        <location>
            <begin position="375"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme C-terminal" evidence="15">
        <location>
            <begin position="477"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ARD85104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="NOL60394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="787" mass="88479" checksum="9CF2429DC8DDCA4C" modified="2017-06-07" version="1">MTDRTSARILWFSEISKEDLPLVGGKSANLGEMVRMKTVPVPNGFSTTSYAYKEFITENDLDDKIINIIKHTDIENSTKLKEASEEIRQLFLNAHFNASLGKEIREYYRKLIEKEKNVYVAVRSSATSEDLPDASFAGEQDTYLNIHGEDDVVQNIKACYASLFSPRAIYYREKKNFGHFNIYLAVAVQKQLFSEVSGVMFTVDVSTGDNSKIIIESSYGLGEYIVGGVVTPDTYYVDKSTMKITNKIITNKNKMLKCLETGGTEELVVEKEMANKQSLSDEEVIHLANYGLQLEKHYGNSMDVEWAKDSFDHKIYILQARFETVWNGNRVGEDKMQQEKEANENEVILKGLPASPGKVAGVAKVLLSVDEMDKFKEGDILVTKMTAPDWVPIMGKAKAIVTDEGGLTCHAAIISRELGVPCIVGTSSYGKKATEVLKDGETITIDAKNGLIYLGGITTGTEEKTPEQNVSYESDIITGTKVLVNMGEPQLSEKVSKLPSDGIGLMREEFIWAEIGEHPLSLIKNGRGEYFVDRLSSELAKVCRDFAPRPVVLRFSDFKSDEYKSLKGGKEFEPEEDNPLLGWRGASRYYDDRYKEAFKLELQGIKKARDEYLLKNLWVMIPFTRTVEELKRVVKIMEDNGLERTKDFKLFLMAEIPSNILLADKFNQYVDGYSIGSNDLTMLLLGSDRNNGKMSSMFDERDLAIKRAIRYLIKIAHRDGKIVSICGQAPSQYDEIVDFLVRSGIDDISVNPDAVTHVRKMVASVEKRIQLEAALGKVYSDPDWDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4T5</accession>
    <name>A0A1V0N4T5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF202 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FAD_1253</name>
        <name evidence="9" type="ORF">HLB00_03005</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Berkeley</strain>
            <strain evidence="10">Y</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000097">
        <property type="protein sequence ID" value="NOL59804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142676.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4T5"/>
    <dbReference type="STRING" id="74969.FAD_1253"/>
    <dbReference type="GeneID" id="84217848"/>
    <dbReference type="KEGG" id="fai:FAD_1253"/>
    <dbReference type="OrthoDB" id="57223at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD85121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="NOL59804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="112" mass="12701" checksum="FB51631775F913F9" modified="2017-06-07" version="1">MSSDTDHFANKRTFLAWMRTGISLMGFGFVIAKFVIFLHALENKPTSSFSTSLIAGEVMIIVGIITIGYGFYEYYSNEKDIDNNKYYSRTTELFVFTAIIIGMAILLLLFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N4V3</accession>
    <name>A0A1V0N4V3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142672.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N4V3"/>
    <dbReference type="STRING" id="74969.FAD_1251"/>
    <dbReference type="GeneID" id="31676749"/>
    <dbReference type="KEGG" id="fai:FAD_1251"/>
    <dbReference type="OrthoDB" id="33090at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="104" mass="12371" checksum="A08A65CD4EC63544" modified="2017-06-07" version="1">MTLEKVIKIQADYRDSGLVERIAASFRRFWVDIKWMDMECDSGVCTIYMSIYDAHNLGNLDLSIVTLSKMVDIDFVEELEEYEYKKFEMNYKKSKKFEWGVISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N533</accession>
    <name>A0A1V0N533_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N533"/>
    <dbReference type="STRING" id="74969.FAD_1336"/>
    <dbReference type="KEGG" id="fai:FAD_1336"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="135" mass="15127" checksum="E19DED61D672FBA1" modified="2017-06-07" version="1">MNEIIMEIFKKERTIDTTKNLPDLINAFSQYLTDNKWRVQSNVQADKAILQAQKFGILRGLVAADRALTFLFTSEGSQVKVQVGVGKLLGDIAVTAIEVILLSEIFIVVDVPEIAWSDHVEKELLDELQNIATQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N548</accession>
    <name>A0A1V0N548_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N548"/>
    <dbReference type="STRING" id="74969.FAD_1357"/>
    <dbReference type="KEGG" id="fai:FAD_1357"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <sequence length="344" mass="39692" checksum="C09C5918E3FD5921" modified="2017-06-07" version="1">MKLISLSEKFIIYVTEQTILISLTSLIASIFHIKDAFLGFFLAYKIDFIPGFLHIFDTNYGLYNLLILFLISFCYYSIESLTGHGIAEDIFKLEIINKYEISKNKLLKLLLVRDIIKSFFISNIINSLFILKNKKFLQNEYDNKFNLMSIKNKNENKKSLFLQYFYSSMIMYYSIFFILIIIYTFVQPAAPLASSGTVKSGSYNYWHFFSTILKNNITLDVFEYMIGGFSLFTGTFIELFSSNIYEAIIMSSLDITHGSSSFVKYILPQFFPETLGYVFGLSIALVMTDIILSFTQSMIRNEKSQYFTQRTHDLLYSSGFYLILSISLLVIGALIEAGLGIYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5I0</accession>
    <name>A0A1V0N5I0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF92 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1534</name>
        <name evidence="8" type="ORF">HLB00_03605</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000114">
        <property type="protein sequence ID" value="NOL59919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886670.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5I0"/>
    <dbReference type="STRING" id="74969.FAD_1534"/>
    <dbReference type="GeneID" id="16024800"/>
    <dbReference type="GeneID" id="31677025"/>
    <dbReference type="KEGG" id="fai:FAD_1534"/>
    <dbReference type="OrthoDB" id="28948at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL59919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="237" mass="25428" checksum="124AB595F1F4F788" modified="2017-06-07" version="1">MSIYYIIESAVLLILLFVLALKFRIFDLKGTIAALIVGVIIVVLGSLYWLILMLIFAITAQMATKYRIKEKTKMKLQEGENGERHASNVIYAAVIGIAIAAMHFAKIGGFPYFLIFGVSFASVNADTFASEIGVFDSKVYMITGFKKITPGVNGGVSLLGEGAALLGAFIIGLSYIILDFHGFAIIPLLAITILGFVGCQIDSILGAVFENKGKMSKGQVNAVSTLLAVALAFVIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5K0</accession>
    <name>A0A1V0N5K0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-NAD kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FAD_1532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Y</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886668.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5K0"/>
    <dbReference type="STRING" id="74969.FAD_1532"/>
    <dbReference type="GeneID" id="16024798"/>
    <dbReference type="GeneID" id="31677023"/>
    <dbReference type="KEGG" id="fai:FAD_1532"/>
    <dbReference type="OrthoDB" id="56451at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039065">
        <property type="entry name" value="AcoX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011386">
        <property type="entry name" value="Put_ATP-NAD_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40697">
        <property type="entry name" value="ACETOIN CATABOLISM PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40697:SF2">
        <property type="entry name" value="ATP-NAD KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016907">
        <property type="entry name" value="Kin_ATP-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ARD85381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38165" checksum="2B6F2CDB39BA3ABF" modified="2017-06-07" version="1">MKVKVAAFFVNPLAGYGGIRNNKGSDNMHLQNIGESVSIGRAIEFLSGIKCRDIQFIVPDGPMGALEMDKANLKYTISYSPGNPTTAMDTINFIHSAAGADIICFLGGDGTARDILRSGTDLPVLGIPAGVKMYSSVFSMNVKHAIDVFDNFCGNEITLKDAGVADINEDEYRSGKLDVKQFGTLKIPDSSGIISSSKAEYPPSSSYDMAEYIIDNMVNDFYYIIGPGTTCKAITTSLGFHTNMLGFDIVKGKKLIVEDAGEEDIYRYAASGSVHIIISIIGGQGFLLGRGNQQLSGRIIKKAGFENISVISTPEKLISLSGLAVDISDKDISVPKFIRVLTGYGQFKIMRVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5P0</accession>
    <name>A0A1V0N5P0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate 5-dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1607</name>
        <name evidence="3" type="ORF">HLB00_01620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000043">
        <property type="protein sequence ID" value="NOL59535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886740.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5P0"/>
    <dbReference type="STRING" id="74969.FAD_1607"/>
    <dbReference type="GeneID" id="16024873"/>
    <dbReference type="GeneID" id="31677097"/>
    <dbReference type="KEGG" id="fai:FAD_1607"/>
    <dbReference type="OrthoDB" id="8744at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="262" mass="29218" checksum="8D73AD589F385B9E" modified="2017-06-07" version="1">MNFSALIGNPVGHSIGQDIYNSLFMDYGIDSMYIAIDLHRKNLPRFFDLSRGNIEGFNITAPYKEESIQFIDYADKIVSDTGSVNLVKNQGGKLYGYNSDYAGFMMLARKNNIDFSGKNVIIMGTGGAARTVAYSIMQNYNSNISIVSRNPGEKKIYGIATTGYNDIKEYDIIINCTPLGTFPDTGMPIPENMIHNGITGIDLVYNPSRTPFLKIVEKNGGIPVNGEDMFIGQGIETLKKIYGITVDYEKFYDIFHENLRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5R3</accession>
    <name>A0A1V0N5R3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-isopropylmalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FAD_1589</name>
        <name evidence="7" type="ORF">HLB00_01525</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Berkeley</strain>
            <strain evidence="8">Y</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 28986</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000041">
        <property type="protein sequence ID" value="NOL59517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081142973.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5R3"/>
    <dbReference type="STRING" id="74969.FAD_1589"/>
    <dbReference type="GeneID" id="31677079"/>
    <dbReference type="KEGG" id="fai:FAD_1589"/>
    <dbReference type="OrthoDB" id="6555at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03174">
        <property type="entry name" value="DRE_TIM_metallolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42880">
        <property type="entry name" value="HOMOCITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42880:SF1">
        <property type="entry name" value="ISOPROPYLMALATE_HOMOCITRATE_CITRAMALATE SYNTHASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ARD85435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="NOL59517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="345" mass="38091" checksum="BCE26727F696C0D3" modified="2017-06-07" version="1">MLTDDTLREGMQTPGFAMSYDEKIELAKLISSAGIERALVAYPPAHKSEFDVTAAIVDGKYFQQVFGLGRTVKEDIDMINATGANISLHLPFKLDNLDPIYENIKYACTLGKLVEVGFVDIDMFSVDQITKFCLRMEELNVDVVQLPDTRGKMNPAAIKNVFEAARKATNIKIEAHCHNDYGMAVANTVSAISAGADYIDTTIFATGERNGIADSITLADYLMKNNLEKSLDIKGIRKAYNYMYNLILKKIGVNFFTDNLPIYGNNSGIQTAGTHVAYGNAFTEKNYSVNVYTGKKMIMEILDNNNVAYDKEKIGRIVSMIKDESAIRGEALPVKDIIKIADGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5S0</accession>
    <name>A0A1V0N5S0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF373 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1623</name>
        <name evidence="3" type="ORF">HLB00_02475</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000075">
        <property type="protein sequence ID" value="NOL59699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886754.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5S0"/>
    <dbReference type="STRING" id="74969.FAD_1623"/>
    <dbReference type="GeneID" id="16024888"/>
    <dbReference type="KEGG" id="fai:FAD_1623"/>
    <dbReference type="OrthoDB" id="31282at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815:SF1">
        <property type="entry name" value="DUF373 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="HYPOTHETICAL MEMBRANE PROTEIN, CONSERVED, DUF373 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="375" mass="42229" checksum="06CA346A4E63A0AF" modified="2017-06-07" version="1">MATLVLNVDRDNDYGIKAGVDGPVTGYGECYNAALKLISVDPEDSDANALFGAIKVYEDLQRKNEEVEIALITGDDDVGAKSDEILGKQLDDVLSMEHYDDLILVSDGAEDDYIIPLISSRIRIRYVKHILIRHNENIESLYYYIIRGIKDKKIARKFTIPVGLLLLSYGVSLLAFTIYAMVITKSYVLDPATGAVMFVTIVLGAYFVGRAVEINQLIIKLAADVKEYSQEAKISMLSYLVSFFIIVIGIAYSYESIIKTVPIMNKVLVFISAFVWWVLASFVSKELFDAFDVYMEERHGMSRMWYGISFSLAIVLIVYGMMNYVRYIIGFIPYSSMILYLTYIIAGIIIALSASAVHKYYSSSKSKNHNMMEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N5S6</accession>
    <name>A0A1V0N5S6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">FAD_1609</name>
        <name evidence="10" type="ORF">HLB00_01630</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Berkeley</strain>
            <strain evidence="11">Y</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000043">
        <property type="protein sequence ID" value="NOL59537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886742.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N5S6"/>
    <dbReference type="STRING" id="74969.FAD_1609"/>
    <dbReference type="GeneID" id="16024875"/>
    <dbReference type="GeneID" id="31677099"/>
    <dbReference type="KEGG" id="fai:FAD_1609"/>
    <dbReference type="OrthoDB" id="43788at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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    <accession>A0A1V0N5U1</accession>
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        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Tatusov R.L."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="48"/>
            <end position="331"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ARD85487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="NOL60616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="337" mass="37677" checksum="645ED168606F976A" modified="2017-06-07" version="1">MRTVCFNGHPRLEHELRCRQCNEPFEIVPEGKFYDDMDKNFDYISRWVTLGEVRTPVVKINNDLSFKLDYFSPTYSYKDRGTRNLISYISSRRNELNIEMINEDSSGNAGSSIAAYGISAGFKTNIYVPSNANPAKLKQIESYGAHIIKVDGSRDHVQEEAEHAEGFYASHILNPEFRDGIRTLAYEIFLQGKMPDNIFVPISAGTLLSGLYSGLTHLYNSGEISKVPVIVGVQPENISPVCSFINGEKYDPDNNLSSIADALVAKRPVLMNKMIKIMNDGNRCISVSENEIITARKDLALKGFYAEYSSATVFAAYRKFNFEGSSLLVLTGNGLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N604</accession>
    <name>A0A1V0N604_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multipass membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FAD_1741</name>
        <name evidence="3" type="ORF">HLB00_03895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Berkeley</strain>
            <strain evidence="4">Y</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 28986</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000127">
        <property type="protein sequence ID" value="NOL59975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886883.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N604"/>
    <dbReference type="STRING" id="74969.FAD_1741"/>
    <dbReference type="GeneID" id="16025016"/>
    <dbReference type="KEGG" id="fai:FAD_1741"/>
    <dbReference type="OrthoDB" id="387360at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD85580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="NOL59975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17620" checksum="26519A45458B8615" modified="2017-06-07" version="1">MKSSVEKRMQERIDVKLVLRFIATSFVYFLAGLVIFAVNLIFSLNMHRDPIFVMWLFGGVVMIIFGLSYMFSSGIAKNSAMANNTVHIEYILLNIGVVLFFLGFSLFLGFSGVGSYGIGKPLAITGLMAIIVSMLIHLINIFVMISRDPYKNKKHGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N607</accession>
    <name>A0A1V0N607_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase II large subunit</fullName>
            <shortName evidence="14">Pol II</shortName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Exodeoxyribonuclease large subunit</fullName>
            <ecNumber evidence="14">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">polD2</name>
        <name evidence="14" type="synonym">polC</name>
        <name evidence="18" type="ORF">FAD_1723</name>
        <name evidence="19" type="ORF">HLB00_00170</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Berkeley</strain>
            <strain evidence="20">Y</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">DSM 28986</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 14">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the archaeal DNA polymerase II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EC" id="3.1.11.1" evidence="14"/>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000007">
        <property type="protein sequence ID" value="NOL59254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_081143056.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N607"/>
    <dbReference type="STRING" id="74969.FAD_1723"/>
    <dbReference type="GeneID" id="84218344"/>
    <dbReference type="KEGG" id="fai:FAD_1723"/>
    <dbReference type="OrthoDB" id="7529at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00324">
        <property type="entry name" value="DNApol_II_L_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004475">
        <property type="entry name" value="PolC_DP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056172">
        <property type="entry name" value="PolC_DP2_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056171">
        <property type="entry name" value="PolC_DP2_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016033">
        <property type="entry name" value="PolC_DP2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00354">
        <property type="entry name" value="polC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003103">
        <property type="entry name" value="PRK04023.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210">
        <property type="entry name" value="DNA POLYMERASE II LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210:SF1">
        <property type="entry name" value="DNA POLYMERASE II LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24846">
        <property type="entry name" value="PolC_DP2_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24844">
        <property type="entry name" value="PolC_DP2_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03833">
        <property type="entry name" value="PolC_DP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016275">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase II large subunit DP2 N-terminal" evidence="15">
        <location>
            <begin position="8"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase II large subunit DP2 central" evidence="16">
        <location>
            <begin position="276"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase II large subunit DP2 catalytic" evidence="17">
        <location>
            <begin position="665"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ARD85563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="NOL59254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="1080" mass="121935" checksum="35D96B72348B930E" modified="2017-06-07" version="1">MIDHNLDKYNKILENKVSECYQIAEEARSLGKDVSTEVEIPLANDMAERVEKLIQIDGIADDIRELSKTMSREEVSLAISRKVAERLKDDRRLALEKSVRVGLAILTEGILVAPLEGIKTVDIVSNDDGTEYVDIVYSGPIRSAGGTAQALSVLMADIVRRELNIGSFKATDEEIERYIEEIQAYNRSKHLQYLPTPEEIRLVIGNSPVMIDGEGSEEEEISGHRDMRRIPTNRIRGGMCLVLCEGLIQKSRKVLKYTSLMKMEEWNILENIGKNKKEEKGDNSQKYLRDIIAGRPVFGYPNRPGGFRLRYGRSRLSGLAAASINPVSMYIVDEFIAIGSQIKVELPGKAAAITPCDTIDGPTVLLKSGEHKKIKTIEEAIAVKEEVAEITDLGEILIAYGDFLENNKNLVTSPFTVEWWSYYLKGDLQKYMEKKPDQFEAIEISKKYGIPLYPEYDYYWHDITEDELNSLISVLERSRLHDGNLYIDTDAQDILIKLGIEFKQISGSLEIAEYYPLLVCTGFSIENNIPVKTGSYSSHNVLEAVNQLSGITIKARSPIRVGARLGRPEKAGDRKMKPKVHSLFPILNYGDNRRSILNAAKNKSEYSIELNERICKNCGNETPLTVCENCGSVTYNQKRLKKMNIDLSMVLERAESRLNIKPDQVKDLKGVKKLMSRNCAVEPMEKGILRSIHDISINKDGTCRYDMSDIPITHFKKSELNLTSEQLIELGYPDRELNEIYPQDIIIPEDSAKYLLNVANFVDDMLVRYYNLQPYYSCHSIDDLIGELVIGLAPHTSGGIVSRIIGFSKVSGCYAHPFYHAAKRRNCDGDEDSIMLLLEGLLDFSRDFLPSTTGGLMDAPLVLSAFLDPEEVDKEAMNVDTLWKYPLEFYEATEQGLPPSKIESIMLTMKSKIQTQGIYTDSGFSFDTANLNAGVLMSAYKSIDSMQEKIEKQLGLATKLLSVDENDVAARVISSHFLPDMFGNMRSFFTQEFRCTKCNTKFRRVPLSGKCLKCGSDNIILTIHHGSIIKYLKETEKVMDEYNLPIYLQYQIRRLIDSIDNTFDVAEPVKVEETTLESFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1V0N660</accession>
    <name>A0A1V0N660_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FAD_1801</name>
        <name evidence="8" type="ORF">HLB00_07600</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ferroplasma acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="74969"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Methanobacteriati</taxon>
            <taxon>Thermoplasmatota</taxon>
            <taxon>Thermoplasmata</taxon>
            <taxon>Thermoplasmatales</taxon>
            <taxon>Ferroplasmaceae</taxon>
            <taxon>Ferroplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2011-10" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic and evolutionary patterns in the extreme acidophile Ferroplasma acidiphilum.</title>
            <authorList>
                <person name="Golyshina O.V."/>
                <person name="Kozyavkin S.A."/>
                <person name="Tatusov R.L."/>
                <person name="Slesarev A.I."/>
                <person name="Golyshin P.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Berkeley</strain>
            <strain evidence="9">Y</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2020-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 28986</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP015363">
        <property type="protein sequence ID" value="ARD85640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABGBP010000280">
        <property type="protein sequence ID" value="NOL60692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009886949.1">
        <property type="nucleotide sequence ID" value="NZ_CP015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1V0N660"/>
    <dbReference type="STRING" id="74969.FAD_1801"/>
    <dbReference type="GeneID" id="16025080"/>
    <dbReference type="GeneID" id="31677291"/>
    <dbReference type="KEGG" id="fai:FAD_1801"/>
    <dbReference type="OrthoDB" id="147058at2157"/>
    <dbReference type="Proteomes" id="UP000192050">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000546917">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051328">
        <property type="entry name" value="T7SS_ABC-Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43077:SF10">
        <property type="entry name" value="TRANSPORT PERMEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43077">
        <property type="entry name" value="TRANSPORT PERMEASE YVFS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="6">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD85640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="NOL60692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000546917"/>
        </source>
    </evidence>
    <sequence length="267" mass="29437" checksum="801B000AD9856795" modified="2017-06-07" version="1">MGGLIPLTIRDLKRWYRNPISAVVGVIQPIFWIVLFGSAFDIAKFGGPASSAFFEGAPNYITYLMGGILTIIGLFTGMFSGINIIWDRRLGILQRFLIAPINRASIVFSRILSSVARILVQIVILFVVAFLIPDGLKIEHGFTAMDAVVLVSAVLMISFIFSSLFSIIAVRTTKMESVFGIVNLINLPLMFASFAMFPPDLMAGWLENVARYNPVSWSAQSIRMVIINGTLSASEAHTVLLYMMGLLALTVFMLVLTYVISNKEIRG</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>